-- dump date 20140620_051552 -- class Genbank::misc_feature -- table misc_feature_note -- id note 550538000001 HMMPfam hit to PF08254, Thr operon leader peptide, score 5.2e-05 550538000002 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 550538000003 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 550538000004 putative catalytic residues [active] 550538000005 putative nucleotide binding site [chemical binding]; other site 550538000006 putative aspartate binding site [chemical binding]; other site 550538000007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 550538000008 dimer interface [polypeptide binding]; other site 550538000009 putative threonine allosteric regulatory site; other site 550538000010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 550538000011 putative threonine allosteric regulatory site; other site 550538000012 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 550538000013 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 550538000014 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 2.4e-63 550538000015 PS00324 Aspartokinase signature. 550538000016 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.2e-05 550538000017 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3.8e-07 550538000018 HMMPfam hit to PF03447, Aspartate/homoserine dehydrogenase, NAD-binding, score 3.3e-46 550538000019 HMMPfam hit to PF00742, Homoserine dehydrogenase, catalytic, score 9.2e-101 550538000020 PS01042 Homoserine dehydrogenase signature. 550538000021 homoserine kinase; Provisional; Region: PRK01212 550538000022 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 550538000023 HMMPfam hit to PF00288, GHMP kinase, score 1.8e-20 550538000024 PS00627 GHMP kinases ATP-binding domain. 550538000025 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 4.9e-11 550538000026 threonine synthase; Validated; Region: PRK09225 550538000027 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 550538000028 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538000029 catalytic residue [active] 550538000030 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 5.5e-31 550538000031 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 550538000032 hypothetical protein; Validated; Region: PRK02101 550538000033 HMMPfam hit to PF03883, Protein of unknown function DUF328, score 6.4e-176 550538000034 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538000035 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 550538000036 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 550538000037 HMMPfam hit to PF01235, Sodium:alanine symporter, score 1.8e-239 550538000038 9 probable transmembrane helices predicted for SG0006 by TMHMM2.0 at aa 13-35, 75-97, 136-158, 171-193, 203-225, 301-323, 343-365, 386-408 and 413-435 550538000039 PS00041 Bacterial regulatory proteins, araC family signature. 550538000040 PS00873 Sodium:alanine symporter family signature. 550538000041 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000042 transaldolase-like protein; Provisional; Region: PTZ00411 550538000043 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 550538000044 active site 550538000045 dimer interface [polypeptide binding]; other site 550538000046 catalytic residue [active] 550538000047 HMMPfam hit to PF00923, Transaldolase, score 2.4e-187 550538000048 PS01054 Transaldolase signature 1. 550538000049 PS00958 Transaldolase active site. 550538000050 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 550538000051 MPT binding site; other site 550538000052 trimer interface [polypeptide binding]; other site 550538000053 HMMPfam hit to PF00994, Molybdopterin binding, score 5.3e-31 550538000054 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 550538000055 hypothetical protein; Provisional; Region: PRK10659 550538000056 HMMPfam hit to PF01184, GPR1/FUN34/yaaH, score 3.7e-118 550538000057 6 probable transmembrane helices predicted for SG0009 by TMHMM2.0 at aa 12-34, 38-57, 64-86, 96-118, 125-144 and 148-170 550538000058 PS01114 GPR1/FUN34/yaaH family signature. 550538000059 the sequence has been checked and is believed to be correct 550538000060 HMMPfam hit to PF03667, Protein of unknown function UPF0174, score 1.4e-121 550538000061 hypothetical protein; Provisional; Region: PRK10154 550538000062 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 550538000063 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 550538000064 nucleotide binding site [chemical binding]; other site 550538000065 HMMPfam hit to PF00012, Heat shock protein 70, score 0 550538000066 PS00297 Heat shock hsp70 proteins family signature 1. 550538000067 PS00329 Heat shock hsp70 proteins family signature 2. 550538000068 PS01036 Heat shock hsp70 proteins family signature 3. 550538000069 chaperone protein DnaJ; Provisional; Region: PRK10767 550538000070 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 550538000071 HSP70 interaction site [polypeptide binding]; other site 550538000072 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 550538000073 substrate binding site [polypeptide binding]; other site 550538000074 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 550538000075 Zn binding sites [ion binding]; other site 550538000076 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 550538000077 dimer interface [polypeptide binding]; other site 550538000078 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 4e-40 550538000079 PS00636 Nt-dnaJ domain signature. 550538000080 HMMPfam hit to PF00684, DnaJ central region, score 1.8e-50 550538000081 PS00637 CXXCXGXG dnaJ domain signature. 550538000082 PS00190 Cytochrome c family heme-binding site signature. 550538000083 HMMPfam hit to PF01556, Chaperone DnaJ, C-terminal, score 1.1e-76 550538000084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538000085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538000086 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 550538000087 substrate binding pocket [chemical binding]; other site 550538000088 dimerization interface [polypeptide binding]; other site 550538000089 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.8e-14 550538000090 3 probable transmembrane helices predicted for SG0015 by TMHMM2.0 at aa 15-37, 50-72 and 82-101 550538000091 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 550538000092 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 550538000093 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 550538000094 HMMPfam hit to PF05838, Protein of unknown function DUF847, score 1.2e-101 550538000095 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 550538000096 1 probable transmembrane helix predicted for SG0017 by TMHMM2.0 at aa 127-146 550538000098 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 4e-65 550538000099 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 3.9e-07 550538000100 the sequence has been checked and is believed to be correct 550538000101 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 550538000102 Helix-turn-helix domain; Region: HTH_36; pfam13730 550538000103 bcf fimbrial operon 550538000104 fimbrial protein BcfA; Provisional; Region: PRK15187 550538000105 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.1e-38 550538000106 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 550538000107 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538000108 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538000109 1 probable transmembrane helix predicted for SG0024 by TMHMM2.0 at aa 7-29 550538000110 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 2.3e-51 550538000111 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 550538000112 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 4.3e-08 550538000113 outer membrane usher protein; Provisional; Region: PRK15193 550538000114 PapC N-terminal domain; Region: PapC_N; pfam13954 550538000115 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 550538000116 PapC C-terminal domain; Region: PapC_C; pfam13953 550538000117 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538000118 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000119 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 550538000120 fimbrial protein BcfD; Provisional; Region: PRK15189 550538000121 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0025 550538000122 fimbrial protein BcfE; Provisional; Region: PRK15190 550538000123 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.1e-28 550538000124 fimbrial protein BcfF; Provisional; Region: PRK15191 550538000125 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.8e-42 550538000126 fimbrial chaperone BcfG; Provisional; Region: PRK15192 550538000127 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538000128 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538000129 1 probable transmembrane helix predicted for SG0029 by TMHMM2.0 at aa 13-35 550538000130 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 3.7e-35 550538000131 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 9.4e-11 550538000132 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 550538000133 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 550538000134 catalytic residues [active] 550538000135 HMMPfam hit to PF01323, DSBA oxidoreductase, score 4.9e-11 550538000136 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 550538000137 1 probable transmembrane helix predicted for SG0032 by TMHMM2.0 at aa 128-147 550538000138 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2.4e-06 550538000139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538000140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538000141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538000142 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.2e-16 550538000143 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 550538000144 1 probable transmembrane helix predicted for SG0034 by TMHMM2.0 at aa 128-145 550538000145 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 550538000146 HMMPfam hit to PF05935, Arylsulphotransferase, score 0 550538000147 PS00061 Short-chain dehydrogenases/reductases family signature. 550538000148 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 550538000149 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 550538000150 active site 550538000151 metal binding site [ion binding]; metal-binding site 550538000152 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 550538000153 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 1.4e-43 550538000154 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.5e-16 550538000155 PS00786 5'-nucleotidase signature 2. 550538000156 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 550538000157 HMMPfam hit to PF07135, Protein of unknown function DUF1384, score 1.2e-192 550538000158 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000159 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 550538000160 Sulfatase; Region: Sulfatase; pfam00884 550538000161 1 probable transmembrane helix predicted for SG0038 by TMHMM2.0 at aa 5-27 550538000162 HMMPfam hit to PF00884, Sulphatase, score 6e-61 550538000163 PS00523 Sulfatases signature 1. 550538000164 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 550538000165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538000166 FeS/SAM binding site; other site 550538000167 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 550538000168 HMMPfam hit to PF04055, Radical SAM, score 3.3e-14 550538000169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 550538000170 PS00280 Pancreatic trypsin inhibitor (Kunitz) family signature. 550538000171 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 550538000172 HMMPfam hit to PF05935, Arylsulphotransferase, score 0 550538000173 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 550538000174 HMMPfam hit to PF06965, Na+/H+ antiporter NhaA, score 2.4e-258 550538000175 11 probable transmembrane helices predicted for SG0042 by TMHMM2.0 at aa 7-29, 59-76, 96-115, 125-147, 154-176, 180-202, 215-237, 257-279, 291-313, 328-350 and 357-379 550538000176 PS00044 Bacterial regulatory proteins, lysR family signature. 550538000177 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 550538000178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538000179 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 550538000180 putative dimerization interface [polypeptide binding]; other site 550538000181 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.6e-18 550538000182 PS00044 Bacterial regulatory proteins, lysR family signature. 550538000183 PS00027 'Homeobox' domain signature. 550538000184 putative alpha-glucosidase; Provisional; Region: PRK10658 550538000185 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 550538000186 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 550538000187 putative active site [active] 550538000188 putative catalytic site [active] 550538000189 HMMPfam hit to PF01055, Glycoside hydrolase, family 31, score 3.1e-171 550538000191 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 550538000192 HMMPfam hit to PF01649, Ribosomal protein S20, score 1.3e-43 550538000193 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 550538000194 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 550538000195 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 550538000196 active site 550538000197 Riboflavin kinase; Region: Flavokinase; smart00904 550538000198 HMMPfam hit to PF06574, FAD synthetase, score 4.8e-81 550538000199 HMMPfam hit to PF01687, Riboflavin kinase, score 3.5e-66 550538000200 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 550538000201 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 550538000202 active site 550538000203 HIGH motif; other site 550538000204 nucleotide binding site [chemical binding]; other site 550538000205 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 550538000206 active site 550538000207 KMSKS motif; other site 550538000208 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 550538000209 tRNA binding surface [nucleotide binding]; other site 550538000210 anticodon binding site; other site 550538000211 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 550538000212 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 0 550538000213 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538000214 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 3.7e-55 550538000215 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 1.9e-13 550538000216 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 550538000217 HMMPfam hit to PF01252, Peptidase A8, signal peptidase II, score 2.8e-86 550538000218 4 probable transmembrane helices predicted for SG0050 by TMHMM2.0 at aa 13-35, 67-86, 99-121 and 136-158 550538000219 PS00855 Signal peptidases II signature. 550538000220 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 550538000221 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 550538000222 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 2e-12 550538000223 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 550538000224 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 550538000225 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 550538000226 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 550538000227 HMMPfam hit to PF02401, LytB protein, score 1.3e-188 550538000228 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 550538000229 active site 550538000230 tetramer interface [polypeptide binding]; other site 550538000231 HMMPfam hit to PF01156, Inosine/uridine-preferring nucleoside hydrolase, score 1.4e-148 550538000232 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 550538000233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538000234 active site 550538000235 phosphorylation site [posttranslational modification] 550538000236 intermolecular recognition site; other site 550538000237 dimerization interface [polypeptide binding]; other site 550538000238 Transcriptional regulator; Region: CitT; pfam12431 550538000239 HMMPfam hit to PF00072, Response regulator receiver, score 1.6e-21 550538000240 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 550538000241 PAS domain; Region: PAS; smart00091 550538000242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538000243 ATP binding site [chemical binding]; other site 550538000244 Mg2+ binding site [ion binding]; other site 550538000245 G-X-G motif; other site 550538000246 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.7e-24 550538000247 2 probable transmembrane helices predicted for SG0056 by TMHMM2.0 at aa 20-39 and 173-195 550538000248 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000249 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 550538000250 9 probable transmembrane helices predicted for SG0057 by TMHMM2.0 at aa 13-35, 122-144, 159-178, 180-202, 222-244, 266-288, 308-327, 339-361 and 409-431 550538000251 HMMPfam hit to PF03977, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit, score 2.5e-289 550538000252 oxaloacetate decarboxylase; Provisional; Region: PRK14040 550538000253 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 550538000254 active site 550538000255 catalytic residues [active] 550538000256 metal binding site [ion binding]; metal-binding site 550538000257 homodimer binding site [polypeptide binding]; other site 550538000258 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 550538000259 carboxyltransferase (CT) interaction site; other site 550538000260 biotinylation site [posttranslational modification]; other site 550538000261 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2e-27 550538000262 PS00188 Biotin-requiring enzymes attachment site. 550538000263 HMMPfam hit to PF02436, Conserved carboxylase region, score 3.8e-99 550538000264 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 550538000265 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 3.3e-90 550538000266 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 550538000267 HMMPfam hit to PF04277, Sodium ion-translocating decarboxylase, score 5.8e-31 550538000268 1 probable transmembrane helix predicted for SG0059 by TMHMM2.0 at aa 10-32 550538000269 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 550538000270 HMMPfam hit to PF03390, Citrate carrier protein, score 7.2e-203 550538000271 11 probable transmembrane helices predicted for SG0061 by TMHMM2.0 at aa 21-43, 47-66, 78-100, 115-134, 141-163, 173-195, 208-230, 268-285, 292-311, 331-348 and 360-382 550538000272 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 550538000273 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 550538000274 putative active site [active] 550538000275 (T/H)XGH motif; other site 550538000276 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.3e-06 550538000277 HMMPfam hit to PF08218, Citrate lyase ligase, C-terminal, score 2.8e-136 550538000278 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 550538000279 HMMPfam hit to PF04953, Citrate lyase acyl carrier protein CitD, score 8.7e-60 550538000280 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 550538000281 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 2.8e-111 550538000282 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000283 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 550538000284 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 550538000285 HMMPfam hit to PF04223, Citrate lyase, alpha subunit, score 0 550538000286 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000287 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 550538000288 HMMPfam hit to PF03802, Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, score 1.2e-46 550538000289 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 550538000290 HMMPfam hit to PF01874, Triphosphoribosyl-dephospho-CoA protein, score 4.1e-123 550538000291 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 550538000292 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 550538000293 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 550538000294 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, score 1.8e-66 550538000295 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, score 1e-81 550538000296 PS01298 Dihydrodipicolinate reductase signature. 550538000297 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 550538000298 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 550538000299 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 550538000300 catalytic site [active] 550538000301 subunit interface [polypeptide binding]; other site 550538000302 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase, small chain, score 1.5e-95 550538000303 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.6e-75 550538000304 PS00442 Glutamine amidotransferases class-I active site. 550538000305 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 550538000306 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 550538000307 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 550538000308 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 550538000309 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 550538000310 ATP-grasp domain; Region: ATP-grasp_4; cl17255 550538000311 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 550538000312 IMP binding site; other site 550538000313 dimer interface [polypeptide binding]; other site 550538000314 interdomain contacts; other site 550538000315 partial ornithine binding site; other site 550538000316 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 6.5e-64 550538000317 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000318 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 2.2e-146 550538000319 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 550538000320 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 550538000321 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large chain, oligomerisation, score 2e-68 550538000322 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 2.9e-26 550538000323 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 3.8e-18 550538000324 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 550538000325 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 1.7e-14 550538000326 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 550538000327 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000328 HMMPfam hit to PF02142, MGS-like, score 7.4e-31 550538000329 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 550538000330 carnitine operon protein CaiE; Provisional; Region: PRK13627 550538000331 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 550538000332 putative trimer interface [polypeptide binding]; other site 550538000333 putative metal binding site [ion binding]; other site 550538000334 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.015 550538000335 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 31 550538000336 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.1 550538000337 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 550538000338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 550538000339 substrate binding site [chemical binding]; other site 550538000340 oxyanion hole (OAH) forming residues; other site 550538000341 trimer interface [polypeptide binding]; other site 550538000342 HMMPfam hit to PF00378, Crotonase, core, score 9.3e-85 550538000343 PS00166 Enoyl-CoA hydratase/isomerase signature. 550538000344 the sequence has been checked and is believed to be correct 550538000345 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 4.6e-123 550538000346 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 550538000347 CoA-transferase family III; Region: CoA_transf_3; pfam02515 550538000348 HMMPfam hit to PF02515, CoA-transferase family III, score 7.4e-100 550538000349 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 550538000350 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 550538000351 active site 550538000352 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 1.9e-59 550538000353 PS00073 Acyl-CoA dehydrogenases signature 2. 550538000354 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase/oxidase, central region, score 1.4e-16 550538000355 PS00072 Acyl-CoA dehydrogenases signature 1. 550538000356 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 2e-50 550538000357 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 550538000358 HMMPfam hit to PF02028, BCCT transporter, score 6.4e-302 550538000359 12 probable transmembrane helices predicted for SG0077 by TMHMM2.0 at aa 13-30, 50-72, 92-114, 144-163, 195-214, 229-251, 264-286, 312-334, 347-366, 410-432, 445-467 and 472-494 550538000360 PS01303 BCCT family of transporters signature. 550538000361 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 550538000362 Ligand binding site [chemical binding]; other site 550538000363 Electron transfer flavoprotein domain; Region: ETF; pfam01012 550538000364 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/beta-subunit, N-terminal, score 2.4e-62 550538000365 PS01065 Electron transfer flavoprotein beta-subunit signature. 550538000366 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 550538000367 Electron transfer flavoprotein domain; Region: ETF; smart00893 550538000368 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 550538000369 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/beta-subunit, N-terminal, score 6.7e-37 550538000370 HMMPfam hit to PF00766, Electron transfer flavoprotein, alpha subunit, C-terminal, score 7.2e-43 550538000371 PS00696 Electron transfer flavoprotein alpha-subunit signature. 550538000372 putative oxidoreductase FixC; Provisional; Region: PRK10157 550538000373 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.1e-13 550538000374 ferredoxin-like protein FixX; Provisional; Region: PRK15449 550538000375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538000376 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 550538000377 putative substrate translocation pore; other site 550538000378 11 probable transmembrane helices predicted for SG0082 by TMHMM2.0 at aa 19-41, 54-76, 85-104, 109-131, 144-166, 171-193, 244-266, 281-303, 324-346, 372-394 and 399-421 550538000379 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 8.5e-35 550538000380 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 550538000381 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 3.2e-45 550538000382 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000383 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538000384 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.5e-25 550538000385 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 550538000386 Sulfatase; Region: Sulfatase; cl17466 550538000387 Sulfatase; Region: Sulfatase; cl17466 550538000388 Sulfatase; Region: Sulfatase; cl17466 550538000389 HMMPfam hit to PF00884, Sulphatase, score 4.9e-22 550538000390 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 550538000391 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.4e-46 550538000392 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 550538000393 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 550538000394 TrkA-N domain; Region: TrkA_N; pfam02254 550538000395 13 probable transmembrane helices predicted for SG0088 by TMHMM2.0 at aa 5-24, 26-45, 55-74, 86-108, 112-134, 147-169, 179-201, 214-233, 237-254, 267-289, 293-315, 327-349 and 359-378 550538000396 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 3.3e-65 550538000397 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000398 HMMPfam hit to PF02254, TrkA-N, score 2.3e-36 550538000399 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 550538000400 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 550538000401 folate binding site [chemical binding]; other site 550538000402 NADP+ binding site [chemical binding]; other site 550538000403 HMMPfam hit to PF00186, Dihydrofolate reductase region, score 7.1e-58 550538000404 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538000405 PS00075 Dihydrofolate reductase signature. 550538000406 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 550538000407 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 550538000408 active site 550538000409 metal binding site [ion binding]; metal-binding site 550538000410 HMMPfam hit to PF00149, Metallophosphoesterase, score 4.7e-18 550538000411 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 550538000412 HMMPfam hit to PF04379, ApaG, score 4.4e-78 550538000413 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 550538000414 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 550538000415 HMMPfam hit to PF00398, Ribosomal RNA adenine methylase transferase, score 7.4e-104 550538000416 PS01131 Ribosomal RNA adenine dimethylases signature. 550538000417 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 550538000418 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 550538000419 HMMPfam hit to PF04166, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA, score 3.1e-183 550538000420 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 550538000421 SurA N-terminal domain; Region: SurA_N; pfam09312 550538000422 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 550538000423 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 550538000424 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 5.2e-50 550538000425 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 550538000426 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000427 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 9.3e-43 550538000428 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 550538000429 HMMPfam hit to PF09312, SurA N-terminal domain, score 6.3e-90 550538000430 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 550538000431 OstA-like protein; Region: OstA; pfam03968 550538000432 Organic solvent tolerance protein; Region: OstA_C; pfam04453 550538000433 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 1.7e-148 550538000434 HMMPfam hit to PF03968, OstA-like protein, score 2.1e-68 550538000435 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 550538000436 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 550538000437 putative metal binding site [ion binding]; other site 550538000438 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 550538000439 HSP70 interaction site [polypeptide binding]; other site 550538000440 1 probable transmembrane helix predicted for SG0096 by TMHMM2.0 at aa 7-29 550538000441 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 1.1e-11 550538000442 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 550538000443 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 550538000444 active site 550538000445 HMMPfam hit to PF00849, Pseudouridine synthase, score 7.6e-61 550538000446 PS01129 Rlu family of pseudouridine synthase signature. 550538000447 ATP-dependent helicase HepA; Validated; Region: PRK04914 550538000448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538000449 ATP binding site [chemical binding]; other site 550538000450 putative Mg++ binding site [ion binding]; other site 550538000451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538000452 nucleotide binding region [chemical binding]; other site 550538000453 ATP-binding site [chemical binding]; other site 550538000454 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.7e-20 550538000455 HMMPfam hit to PF00176, SNF2-related, score 9.8e-83 550538000456 DNA polymerase II; Reviewed; Region: PRK05762 550538000457 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 550538000458 active site 550538000459 catalytic site [active] 550538000460 substrate binding site [chemical binding]; other site 550538000461 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 550538000462 active site 550538000463 metal-binding site 550538000464 HMMPfam hit to PF00136, DNA polymerase, B region, score 2.5e-33 550538000465 PS00116 DNA polymerase family B signature. 550538000466 HMMPfam hit to PF03104, DNA polymerase B, exonuclease, score 3.3e-55 550538000467 Uncharacterized conserved protein [Function unknown]; Region: COG1434 550538000468 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 550538000469 putative active site [active] 550538000470 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 8.2e-54 550538000471 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000472 1 probable transmembrane helix predicted for SG0100 by TMHMM2.0 at aa 5-27 550538000473 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 550538000474 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 550538000475 intersubunit interface [polypeptide binding]; other site 550538000476 active site 550538000477 Zn2+ binding site [ion binding]; other site 550538000478 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 2.5e-103 550538000479 L-arabinose isomerase; Provisional; Region: PRK02929 550538000480 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 550538000481 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 550538000482 trimer interface [polypeptide binding]; other site 550538000483 putative substrate binding site [chemical binding]; other site 550538000484 putative metal binding site [ion binding]; other site 550538000485 HMMPfam hit to PF02610, L-arabinose isomerase, score 0 550538000486 ribulokinase; Provisional; Region: PRK04123 550538000487 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 550538000488 N- and C-terminal domain interface [polypeptide binding]; other site 550538000489 active site 550538000490 MgATP binding site [chemical binding]; other site 550538000491 catalytic site [active] 550538000492 metal binding site [ion binding]; metal-binding site 550538000493 carbohydrate binding site [chemical binding]; other site 550538000494 homodimer interface [polypeptide binding]; other site 550538000495 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 2.2e-06 550538000496 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 3e-06 550538000497 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 550538000498 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 550538000499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538000500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538000501 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 1.2e-27 550538000502 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.6e-11 550538000503 PS00041 Bacterial regulatory proteins, araC family signature. 550538000504 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.8e-12 550538000505 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 550538000506 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 550538000507 5 probable transmembrane helices predicted for SG0106 by TMHMM2.0 at aa 13-35, 57-79, 140-162, 177-199 and 219-241 550538000508 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 0.00014 550538000509 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 550538000510 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 550538000511 Walker A/P-loop; other site 550538000512 ATP binding site [chemical binding]; other site 550538000513 Q-loop/lid; other site 550538000514 ABC transporter signature motif; other site 550538000515 Walker B; other site 550538000516 D-loop; other site 550538000517 H-loop/switch region; other site 550538000518 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-63 550538000519 PS00211 ABC transporters family signature. 550538000520 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000521 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 550538000522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538000523 dimer interface [polypeptide binding]; other site 550538000524 conserved gate region; other site 550538000525 putative PBP binding loops; other site 550538000526 ABC-ATPase subunit interface; other site 550538000527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538000528 dimer interface [polypeptide binding]; other site 550538000529 conserved gate region; other site 550538000530 putative PBP binding loops; other site 550538000531 ABC-ATPase subunit interface; other site 550538000532 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 0.0024 550538000533 12 probable transmembrane helices predicted for SG0108 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 127-149, 199-221, 241-260, 293-315, 335-357, 370-392, 407-424, 462-484 and 508-525 550538000534 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-06 550538000535 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 550538000536 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 550538000537 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 550538000538 transcriptional regulator SgrR; Provisional; Region: PRK13626 550538000539 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 550538000540 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 550538000541 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 6.8e-49 550538000542 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 550538000543 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 550538000544 substrate binding site [chemical binding]; other site 550538000545 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 9.9e-67 550538000546 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 550538000547 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 550538000548 substrate binding site [chemical binding]; other site 550538000549 ligand binding site [chemical binding]; other site 550538000550 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 9.3e-284 550538000551 PS01244 Aconitase family signature 2. 550538000552 PS00450 Aconitase family signature 1. 550538000553 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 550538000554 tartrate dehydrogenase; Region: TTC; TIGR02089 550538000555 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 4.6e-226 550538000556 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 550538000557 2-isopropylmalate synthase; Validated; Region: PRK00915 550538000558 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 550538000559 active site 550538000560 catalytic residues [active] 550538000561 metal binding site [ion binding]; metal-binding site 550538000562 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 550538000563 HMMPfam hit to PF08502, LeuA allosteric (dimerisation) domain, score 2.9e-63 550538000564 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 5.4e-151 550538000565 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 550538000566 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 550538000567 leu operon leader peptide; Provisional; Region: PRK14744 550538000568 HMMPfam hit to PF08054, Leucine operon leader peptide, score 6.6e-16 550538000569 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 550538000570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538000571 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 550538000572 putative substrate binding pocket [chemical binding]; other site 550538000573 putative dimerization interface [polypeptide binding]; other site 550538000574 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.1e-19 550538000575 PS00044 Bacterial regulatory proteins, lysR family signature. 550538000576 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.1e-08 550538000577 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 550538000578 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 550538000579 dimer interface [polypeptide binding]; other site 550538000580 PYR/PP interface [polypeptide binding]; other site 550538000581 TPP binding site [chemical binding]; other site 550538000582 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 550538000583 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 550538000584 TPP-binding site [chemical binding]; other site 550538000585 dimer interface [polypeptide binding]; other site 550538000586 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 5.3e-88 550538000587 PS00044 Bacterial regulatory proteins, lysR family signature. 550538000588 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 8.9e-67 550538000589 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 8.7e-77 550538000590 PS00187 Thiamine pyrophosphate enzymes signature. 550538000591 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 550538000592 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 550538000593 putative valine binding site [chemical binding]; other site 550538000594 dimer interface [polypeptide binding]; other site 550538000595 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 550538000596 PS00430 TonB-dependent receptor proteins signature 1. 550538000597 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3.9e-13 550538000598 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 550538000599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538000600 DNA binding site [nucleotide binding] 550538000601 domain linker motif; other site 550538000602 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 550538000603 dimerization interface [polypeptide binding]; other site 550538000604 ligand binding site [chemical binding]; other site 550538000605 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.6e-10 550538000606 PS00356 Bacterial regulatory proteins, lacI family signature. 550538000607 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 7.6e-07 550538000608 mraZ protein; Region: TIGR00242 550538000609 MraZ protein; Region: MraZ; pfam02381 550538000610 MraZ protein; Region: MraZ; pfam02381 550538000611 HMMPfam hit to PF02381, MraZ, score 4.1e-29 550538000612 HMMPfam hit to PF02381, MraZ, score 1.3e-23 550538000613 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 550538000614 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 550538000615 HMMPfam hit to PF01795, Bacterial methyltransferase, score 2.4e-193 550538000616 cell division protein FtsL; Provisional; Region: PRK10772 550538000617 HMMPfam hit to PF04999, Cell division protein FtsL, score 1.2e-65 550538000618 1 probable transmembrane helix predicted for SG0122 by TMHMM2.0 at aa 35-57 550538000619 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 550538000620 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 550538000621 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 550538000622 1 probable transmembrane helix predicted for SG0123 by TMHMM2.0 at aa 21-43 550538000623 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 1.5e-67 550538000624 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 5e-120 550538000625 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 550538000626 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 550538000627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 550538000628 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 550538000629 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.9e-15 550538000630 HMMPfam hit to PF08245, Mur ligase, central, score 1.1e-75 550538000631 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 8.3e-40 550538000632 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 550538000633 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 550538000634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 550538000635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 550538000636 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 8.1e-21 550538000637 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000638 HMMPfam hit to PF08245, Mur ligase, central, score 5.9e-70 550538000639 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 4.6e-18 550538000640 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 550538000641 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 550538000642 Mg++ binding site [ion binding]; other site 550538000643 putative catalytic motif [active] 550538000644 putative substrate binding site [chemical binding]; other site 550538000645 10 probable transmembrane helices predicted for SG0126 by TMHMM2.0 at aa 15-37, 75-92, 97-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 550538000646 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 2.9e-86 550538000647 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 550538000648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 550538000649 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 550538000650 1 probable transmembrane helix predicted for SG0127 by TMHMM2.0 at aa 9-31 550538000651 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000652 HMMPfam hit to PF08245, Mur ligase, central, score 2.8e-60 550538000653 PS00012 Phosphopantetheine attachment site. 550538000654 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 9.4e-14 550538000655 cell division protein FtsW; Provisional; Region: PRK10774 550538000656 HMMPfam hit to PF01098, Cell cycle protein, score 3.1e-189 550538000657 8 probable transmembrane helices predicted for SG0128 by TMHMM2.0 at aa 20-42, 57-74, 81-103, 155-177, 190-212, 278-300, 312-334 and 344-366 550538000658 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 550538000659 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 550538000660 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 550538000661 active site 550538000662 homodimer interface [polypeptide binding]; other site 550538000663 HMMPfam hit to PF03033, Glycosyl transferase, family 28, score 3.6e-53 550538000664 HMMPfam hit to PF04101, Glycosyltransferase 28, C-terminal, score 6.5e-57 550538000665 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 550538000666 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 550538000667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 550538000668 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 550538000669 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.1e-47 550538000670 HMMPfam hit to PF08245, Mur ligase, central, score 1e-35 550538000671 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 2.1e-23 550538000672 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 550538000673 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 550538000674 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 550538000675 HMMPfam hit to PF01820, D-alanine--D-alanine ligase, N-terminal, score 2.7e-55 550538000676 PS00843 D-alanine--D-alanine ligase signature 1. 550538000677 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538000678 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 2.5e-107 550538000679 PS00844 D-alanine--D-alanine ligase signature 2. 550538000680 cell division protein FtsQ; Provisional; Region: PRK10775 550538000681 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 550538000682 Cell division protein FtsQ; Region: FtsQ; pfam03799 550538000683 1 probable transmembrane helix predicted for SG0132 by TMHMM2.0 at aa 26-48 550538000684 HMMPfam hit to PF08478, Polypeptide-transport-associated, FtsQ-type, score 1.2e-24 550538000685 HMMPfam hit to PF03799, Cell division protein FtsQ, score 7.5e-36 550538000686 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 550538000687 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538000688 Cell division protein FtsA; Region: FtsA; pfam14450 550538000689 HMMPfam hit to PF02491, Cell division protein FtsA, score 7.6e-79 550538000690 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000691 HMMPfam hit to PF02491, Cell division protein FtsA, score 2.1e-79 550538000692 cell division protein FtsZ; Validated; Region: PRK09330 550538000693 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 550538000694 nucleotide binding site [chemical binding]; other site 550538000695 SulA interaction site; other site 550538000696 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 550538000697 HMMPfam hit to PF00091, Tubulin/FtsZ, GTPase, score 1.1e-93 550538000698 PS01134 FtsZ protein signature 1. 550538000699 PS01135 FtsZ protein signature 2. 550538000700 HMMPfam hit to PF03953, Tubulin/FtsZ, C-terminal, score 2.1e-44 550538000701 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 550538000702 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 550538000703 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglucosamine deacetylase, score 4e-193 550538000704 SecA regulator SecM; Provisional; Region: PRK02943 550538000705 HMMPfam hit to PF06558, Secretion monitor, score 3.6e-105 550538000706 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 550538000707 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 550538000708 SEC-C motif; Region: SEC-C; pfam02810 550538000709 HMMPfam hit to PF07517, SecA DEAD-like, score 2.3e-218 550538000710 HMMPfam hit to PF01043, SecA preprotein cross-linking region, score 1.3e-83 550538000711 PS01312 Protein secA signatures. 550538000712 HMMPfam hit to PF07516, SecA Wing and Scaffold, score 3.6e-124 550538000713 HMMPfam hit to PF02810, SEC-C motif, score 2.8e-11 550538000714 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 550538000715 active site 550538000716 8-oxo-dGMP binding site [chemical binding]; other site 550538000717 nudix motif; other site 550538000718 metal binding site [ion binding]; metal-binding site 550538000719 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.5e-30 550538000720 PS00893 mutT domain signature. 550538000721 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538000722 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538000723 active site 550538000724 catalytic tetrad [active] 550538000725 HMMPfam hit to PF00248, Aldo/keto reductase, score 1.8e-68 550538000726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538000727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538000728 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 550538000729 putative effector binding pocket; other site 550538000730 putative dimerization interface [polypeptide binding]; other site 550538000731 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.7e-21 550538000732 PS00044 Bacterial regulatory proteins, lysR family signature. 550538000733 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.2e-39 550538000734 DNA gyrase inhibitor; Reviewed; Region: PRK00418 550538000735 HMMPfam hit to PF03884, Protein of unknown function DUF329, score 1.9e-36 550538000736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 550538000737 HMMPfam hit to PF07072, Protein of unknown function DUF1342, score 1.5e-162 550538000738 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 550538000739 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 550538000740 CoA-binding site [chemical binding]; other site 550538000741 ATP-binding [chemical binding]; other site 550538000742 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 4.3e-110 550538000743 PS01294 Uncharacterized protein family UPF0038 signature. 550538000744 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000745 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 550538000746 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 550538000747 active site 550538000748 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 1.3e-161 550538000749 PS00487 IMP dehydrogenase / GMP reductase signature. 550538000750 type IV pilin biogenesis protein; Provisional; Region: PRK10573 550538000751 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 550538000752 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 550538000753 3 probable transmembrane helices predicted for SG0144 by TMHMM2.0 at aa 163-185, 205-227 and 368-390 550538000754 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 6e-17 550538000755 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 1.1e-19 550538000756 hypothetical protein; Provisional; Region: PRK10436 550538000757 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 550538000758 Walker A motif; other site 550538000759 ATP binding site [chemical binding]; other site 550538000760 Walker B motif; other site 550538000761 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 3.1e-123 550538000762 PS00662 Bacterial type II secretion system protein E signature. 550538000763 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000764 HMMPfam hit to PF05157, General secretory system II, protein E, N-terminal, score 3.3e-05 550538000765 putative major pilin subunit; Provisional; Region: PRK10574 550538000766 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 550538000767 Pilin (bacterial filament); Region: Pilin; pfam00114 550538000768 1 probable transmembrane helix predicted for SG0146 by TMHMM2.0 at aa 7-29 550538000769 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 1.9e-08 550538000770 PS00409 Prokaryotic N-terminal methylation site. 550538000771 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 550538000772 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 550538000773 dimerization interface [polypeptide binding]; other site 550538000774 active site 550538000775 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, score 2.8e-94 550538000776 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, score 1.3e-32 550538000777 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 550538000778 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 550538000779 amidase catalytic site [active] 550538000780 Zn binding residues [ion binding]; other site 550538000781 substrate binding site [chemical binding]; other site 550538000782 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, family 2, score 6.1e-65 550538000783 regulatory protein AmpE; Provisional; Region: PRK10987 550538000784 4 probable transmembrane helices predicted for SG0149 by TMHMM2.0 at aa 5-22, 24-46, 107-129 and 227-244 550538000785 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 550538000786 active site 550538000787 HMMPfam hit to PF04616, Glycoside hydrolase, family 43, score 6.7e-135 550538000788 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 550538000789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538000790 putative substrate translocation pore; other site 550538000791 12 probable transmembrane helices predicted for SG0151 by TMHMM2.0 at aa 12-31, 35-57, 81-100, 115-137, 150-172, 182-204, 234-256, 266-288, 295-317, 322-344, 365-387 and 407-429 550538000792 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 6.2e-09 550538000793 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538000794 aromatic amino acid transporter; Provisional; Region: PRK10238 550538000795 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.1e-171 550538000796 12 probable transmembrane helices predicted for SG0152 by TMHMM2.0 at aa 21-43, 47-66, 86-108, 118-140, 153-175, 198-220, 240-262, 282-304, 331-353, 357-379, 399-421 and 426-445 550538000797 PS00218 Amino acid permeases signature. 550538000798 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 550538000799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538000800 DNA-binding site [nucleotide binding]; DNA binding site 550538000801 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 550538000802 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.9e-34 550538000803 PS00043 Bacterial regulatory proteins, gntR family signature. 550538000804 HMMPfam hit to PF07729, GntR, C-terminal, score 1.1e-30 550538000805 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 550538000806 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 550538000807 dimer interface [polypeptide binding]; other site 550538000808 TPP-binding site [chemical binding]; other site 550538000809 HMMPfam hit to PF00456, Transketolase, N-terminal, score 7e-05 550538000810 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 550538000811 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 550538000812 E3 interaction surface; other site 550538000813 lipoyl attachment site [posttranslational modification]; other site 550538000814 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 550538000815 E3 interaction surface; other site 550538000816 lipoyl attachment site [posttranslational modification]; other site 550538000817 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 550538000818 E3 interaction surface; other site 550538000819 lipoyl attachment site [posttranslational modification]; other site 550538000820 e3 binding domain; Region: E3_binding; pfam02817 550538000821 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 550538000822 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 5.4e-29 550538000823 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 550538000824 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 4.2e-29 550538000825 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 550538000826 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 5.4e-28 550538000827 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 550538000828 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000829 HMMPfam hit to PF02817, E3 binding, score 2e-18 550538000830 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 3e-110 550538000831 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 550538000832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 550538000833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538000834 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 550538000835 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.1e-76 550538000836 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 550538000837 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.3e-24 550538000838 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.5e-52 550538000839 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 550538000840 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 550538000841 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 550538000842 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 550538000843 substrate binding site [chemical binding]; other site 550538000844 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 550538000845 substrate binding site [chemical binding]; other site 550538000846 ligand binding site [chemical binding]; other site 550538000847 HMMPfam hit to PF06434, Aconitase B, N-terminal, bacterial, score 3.3e-291 550538000848 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 4.7e-11 550538000849 PS00450 Aconitase family signature 1. 550538000850 PS01244 Aconitase family signature 2. 550538000851 putative inner membrane protein; Provisional; Region: PRK09823 550538000852 4 probable transmembrane helices predicted for SG0161 by TMHMM2.0 at aa 13-35, 50-72, 85-107 and 122-144 550538000853 Low molecular weight phosphatase family; Region: LMWPc; cl00105 550538000854 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 550538000855 active site 550538000856 hypothetical protein; Provisional; Region: PRK05248 550538000857 HMMPfam hit to PF06062, Uncharacterised conserved protein UCP006287, score 3e-72 550538000858 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 550538000859 HMMPfam hit to PF03812, 2-keto-3-deoxygluconate permease, score 3.9e-96 550538000860 10 probable transmembrane helices predicted for SG0164 by TMHMM2.0 at aa 13-35, 45-64, 71-90, 100-122, 134-156, 160-182, 189-211, 215-237, 244-266 and 281-303 550538000861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 550538000862 HMMPfam hit to PF07005, Type III effector Hrp-dependent outers, score 2.1e-05 550538000863 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 550538000864 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 550538000865 HMMPfam hit to PF04166, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA, score 4.8e-117 550538000866 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000867 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538000868 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538000869 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538000870 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 4.4e-19 550538000871 PS00894 Bacterial regulatory proteins, deoR family signature. 550538000872 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.8e-45 550538000873 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 550538000874 HMMPfam hit to PF02675, S-adenosylmethionine decarboxylase related, score 1.3e-78 550538000875 spermidine synthase; Provisional; Region: PRK00811 550538000876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538000877 S-adenosylmethionine binding site [chemical binding]; other site 550538000878 HMMPfam hit to PF01564, Spermine synthase, score 4.4e-134 550538000879 PS00136 Serine proteases, subtilase family, aspartic acid active site. 550538000880 PS01330 Spermidine/spermine synthases family signature. 550538000881 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 550538000882 multicopper oxidase; Provisional; Region: PRK10965 550538000883 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 550538000884 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 550538000885 HMMPfam hit to PF07732, Multicopper oxidase, type 3, score 1e-42 550538000886 HMMPfam hit to PF07731, Multicopper oxidase, type 2, score 2.2e-17 550538000887 PS00080 Multicopper oxidases signature 2. 550538000888 the sequence has been checked and is believed to be correct 550538000889 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 1e-07 550538000890 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 3e-06 550538000891 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.00079 550538000892 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 9.8e-05 550538000893 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.0011 550538000894 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 4.1e-05 550538000895 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 6.2e-08 550538000896 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 550538000897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538000898 active site 550538000899 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 4.7e-39 550538000900 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538000901 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 550538000902 active site clefts [active] 550538000903 zinc binding site [ion binding]; other site 550538000904 dimer interface [polypeptide binding]; other site 550538000905 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.5e-63 550538000906 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 550538000907 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 550538000908 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 550538000909 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 550538000910 Walker A/P-loop; other site 550538000911 ATP binding site [chemical binding]; other site 550538000912 Q-loop/lid; other site 550538000913 ABC transporter signature motif; other site 550538000914 Walker B; other site 550538000915 D-loop; other site 550538000916 H-loop/switch region; other site 550538000917 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-52 550538000918 PS00017 ATP/GTP-binding site motif A (P-loop). 550538000919 PS00211 ABC transporters family signature. 550538000920 inner membrane transport permease; Provisional; Region: PRK15066 550538000921 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 550538000922 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.5e-48 550538000923 6 probable transmembrane helices predicted for SG0176 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163, 170-192 and 226-248 550538000924 PS00890 ABC-2 type transport system integral membrane proteins signature. 550538000925 fimbrial operon sti 550538000926 putative fimbrial protein StiH; Provisional; Region: PRK15297 550538000927 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0015 550538000928 the sequence has been checked and is believed to be correct 550538000929 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538000930 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 550538000931 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538000932 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538000933 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.3e-22 550538000934 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1.1e-46 550538000935 fimbrial protein StiA; Provisional; Region: PRK15300 550538000936 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.5e-32 550538000938 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 1.8e-22 550538000939 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 550538000940 putative active site [active] 550538000941 putative metal binding site [ion binding]; other site 550538000942 1 probable transmembrane helix predicted for SG0183 by TMHMM2.0 at aa 5-27 550538000943 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 2.9e-26 550538000944 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 550538000945 tetramerization interface [polypeptide binding]; other site 550538000946 active site 550538000947 HMMPfam hit to PF02261, Aspartate decarboxylase, score 2.6e-84 550538000948 PS00678 Trp-Asp (WD) repeats signature. 550538000949 Pantoate-beta-alanine ligase; Region: PanC; cd00560 550538000950 pantoate--beta-alanine ligase; Region: panC; TIGR00018 550538000951 active site 550538000952 ATP-binding site [chemical binding]; other site 550538000953 pantoate-binding site; other site 550538000954 HXXH motif; other site 550538000955 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 2.4e-169 550538000956 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 550538000957 oligomerization interface [polypeptide binding]; other site 550538000958 active site 550538000959 metal binding site [ion binding]; metal-binding site 550538000960 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 4.6e-170 550538000961 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 550538000962 catalytic center binding site [active] 550538000963 ATP binding site [chemical binding]; other site 550538000964 HMMPfam hit to PF01288, 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK, score 7.2e-75 550538000965 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 550538000966 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 550538000967 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 550538000968 active site 550538000969 NTP binding site [chemical binding]; other site 550538000970 metal binding triad [ion binding]; metal-binding site 550538000971 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 550538000972 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 550538000973 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase region, score 6.3e-74 550538000974 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 550538000975 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 550538000976 active site 550538000977 nucleotide binding site [chemical binding]; other site 550538000978 HIGH motif; other site 550538000979 KMSKS motif; other site 550538000980 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 5.9e-30 550538000981 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 550538000982 HMMPfam hit to PF01258, Zinc finger, DksA/TraR C4-type, score 3.4e-36 550538000983 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 550538000984 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 550538000985 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 2.4e-103 550538000986 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538000987 2'-5' RNA ligase; Provisional; Region: PRK15124 550538000988 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 550538000989 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 550538000990 HMMPfam hit to PF02834, Phosphoesterase, HXTX, score 1.1e-08 550538000991 HMMPfam hit to PF02834, Phosphoesterase, HXTX, score 1.1e-18 550538000992 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 550538000993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538000994 ATP binding site [chemical binding]; other site 550538000995 putative Mg++ binding site [ion binding]; other site 550538000996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538000997 nucleotide binding region [chemical binding]; other site 550538000998 ATP-binding site [chemical binding]; other site 550538000999 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 550538001000 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 4.7e-07 550538001001 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001002 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 8.5e-11 550538001003 HMMPfam hit to PF04408, Helicase-associated region, score 8.7e-08 550538001004 PS00177 DNA topoisomerase II signature. 550538001005 HMMPfam hit to PF08482, RNA helicase, ATP-dependent, HrpB type, C-terminal, score 1.1e-92 550538001006 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 550538001007 Transglycosylase; Region: Transgly; pfam00912 550538001008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 550538001009 1 probable transmembrane helix predicted for SG0194 by TMHMM2.0 at aa 60-82 550538001010 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 5.6e-81 550538001011 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 4.8e-20 550538001012 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001013 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 550538001014 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 550538001015 N-terminal plug; other site 550538001016 ligand-binding site [chemical binding]; other site 550538001017 PS00430 TonB-dependent receptor proteins signature 1. 550538001018 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 2.1e-23 550538001019 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 8.4e-24 550538001020 PS01156 TonB-dependent receptor proteins signature 2. 550538001021 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 550538001022 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 550538001023 Walker A/P-loop; other site 550538001024 ATP binding site [chemical binding]; other site 550538001025 Q-loop/lid; other site 550538001026 ABC transporter signature motif; other site 550538001027 Walker B; other site 550538001028 D-loop; other site 550538001029 H-loop/switch region; other site 550538001030 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-58 550538001031 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001032 PS00211 ABC transporters family signature. 550538001033 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 550538001034 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 550538001035 siderophore binding site; other site 550538001036 PS00228 Tubulin-beta mRNA autoregulation signal. 550538001037 HMMPfam hit to PF01497, Periplasmic binding protein, score 7.1e-09 550538001038 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538001039 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 550538001040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538001041 ABC-ATPase subunit interface; other site 550538001042 dimer interface [polypeptide binding]; other site 550538001043 putative PBP binding regions; other site 550538001044 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538001045 ABC-ATPase subunit interface; other site 550538001046 dimer interface [polypeptide binding]; other site 550538001047 putative PBP binding regions; other site 550538001048 17 probable transmembrane helices predicted for SG0198 by TMHMM2.0 at aa 35-57, 87-104, 117-136, 140-162, 169-191, 264-286, 298-316, 326-348, 372-394, 414-436, 449-467, 471-493, 505-524, 544-566, 593-615, 630-649 and 656-678 550538001049 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001050 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 1.8e-38 550538001051 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 2.6e-62 550538001052 fimbrial operon stf 550538001053 putative fimbrial subunit StfA; Provisional; Region: PRK15283 550538001054 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.4e-27 550538001055 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 550538001056 PapC N-terminal domain; Region: PapC_N; pfam13954 550538001057 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 550538001058 PapC C-terminal domain; Region: PapC_C; pfam13953 550538001059 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538001060 PS00489 Bacteriophage-type RNA polymerase family active site signature 2. 550538001061 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 550538001062 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 550538001063 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538001064 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538001065 1 probable transmembrane helix predicted for SG0201 by TMHMM2.0 at aa 7-29 550538001066 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 3.9e-38 550538001067 PS00635 Gram-negative pili assembly chaperone signature. 550538001068 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 0.00021 550538001069 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 550538001070 the sequence has been checked and is believed to be correct 550538001071 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.00097 550538001072 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 550538001073 1 probable transmembrane helix predicted for SG0204 by TMHMM2.0 at aa 7-26 550538001074 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 3.1e-12 550538001075 the sequence has been checked and is believed to be correct 550538001076 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 550538001077 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 550538001078 inhibitor-cofactor binding pocket; inhibition site 550538001079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538001080 catalytic residue [active] 550538001081 HMMPfam hit to PF00202, Aminotransferase class-III, score 4e-92 550538001082 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 550538001083 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 550538001084 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 550538001085 Cl- selectivity filter; other site 550538001086 Cl- binding residues [ion binding]; other site 550538001087 pore gating glutamate residue; other site 550538001088 dimer interface [polypeptide binding]; other site 550538001089 H+/Cl- coupling transport residue; other site 550538001090 11 probable transmembrane helices predicted for SG0207 by TMHMM2.0 at aa 31-53, 75-97, 124-146, 179-201, 210-232, 252-274, 291-310, 320-342, 355-377, 390-412 and 419-441 550538001091 HMMPfam hit to PF00654, Chloride channel, core, score 1.7e-120 550538001092 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 550538001093 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 1e-42 550538001094 PS01152 Hypothetical hesB/yadR/yfhF family signature. 550538001095 hypothetical protein; Provisional; Region: PRK10578 550538001096 UPF0126 domain; Region: UPF0126; pfam03458 550538001097 UPF0126 domain; Region: UPF0126; pfam03458 550538001098 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 1.6e-32 550538001099 6 probable transmembrane helices predicted for SG0209 by TMHMM2.0 at aa 4-23, 30-47, 62-79, 88-105, 115-137 and 149-171 550538001100 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 1e-38 550538001101 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 550538001102 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 550538001103 cobalamin binding residues [chemical binding]; other site 550538001104 putative BtuC binding residues; other site 550538001105 dimer interface [polypeptide binding]; other site 550538001106 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.4e-51 550538001107 1 probable transmembrane helix predicted for SG0210 by TMHMM2.0 at aa 7-29 550538001108 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 550538001109 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 550538001110 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 1.2e-109 550538001111 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 550538001112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 550538001113 Zn2+ binding site [ion binding]; other site 550538001114 Mg2+ binding site [ion binding]; other site 550538001115 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 550538001116 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 5.6e-07 550538001117 serine endoprotease; Provisional; Region: PRK10942 550538001118 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 550538001119 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 550538001120 protein binding site [polypeptide binding]; other site 550538001121 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 550538001122 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 1.8e-35 550538001123 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 1.5e-21 550538001124 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 2.9e-19 550538001125 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 550538001126 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 550538001127 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 550538001128 HMMPfam hit to PF05651, sugar diacid recognition, score 2.6e-170 550538001129 hypothetical protein; Provisional; Region: PRK13677 550538001130 shikimate transporter; Provisional; Region: PRK09952 550538001131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538001132 putative substrate translocation pore; other site 550538001133 11 probable transmembrane helices predicted for SG0216 by TMHMM2.0 at aa 27-46, 51-73, 85-107, 122-144, 151-173, 183-202, 244-266, 276-298, 310-329, 374-396 and 403-425 550538001134 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.2e-12 550538001135 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 550538001136 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 550538001137 trimer interface [polypeptide binding]; other site 550538001138 active site 550538001139 substrate binding site [chemical binding]; other site 550538001140 CoA binding site [chemical binding]; other site 550538001141 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.9 550538001142 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 8.8 550538001143 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.82 550538001144 PS00101 Hexapeptide-repeat containing-transferases signature. 550538001145 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 30 550538001146 PII uridylyl-transferase; Provisional; Region: PRK05007 550538001147 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 550538001148 metal binding triad; other site 550538001149 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 550538001150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 550538001151 Zn2+ binding site [ion binding]; other site 550538001152 Mg2+ binding site [ion binding]; other site 550538001153 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 550538001154 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 550538001155 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.7e-07 550538001156 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3e-07 550538001157 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 4.8e-21 550538001158 HMMPfam hit to PF08335, GlnD PII-uridylyltransferase, score 6.6e-117 550538001159 HMMPfam hit to PF01909, DNA polymerase, beta-like region, score 3.6e-13 550538001160 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 550538001161 active site 550538001162 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 2.8e-105 550538001163 PS00680 Methionine aminopeptidase subfamily 1 signature. 550538001164 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 550538001165 rRNA interaction site [nucleotide binding]; other site 550538001166 S8 interaction site; other site 550538001167 putative laminin-1 binding site; other site 550538001168 PS00962 Ribosomal protein S2 signature 1. 550538001169 HMMPfam hit to PF00318, Ribosomal protein S2, score 5.7e-130 550538001170 PS00963 Ribosomal protein S2 signature 2. 550538001171 elongation factor Ts; Provisional; Region: tsf; PRK09377 550538001172 UBA/TS-N domain; Region: UBA; pfam00627 550538001173 Elongation factor TS; Region: EF_TS; pfam00889 550538001174 Elongation factor TS; Region: EF_TS; pfam00889 550538001175 HMMPfam hit to PF00627, Ubiquitin-associated_translation elongation factor EF1B, N-terminal, score 6.2e-13 550538001176 PS01126 Elongation factor Ts signature 1. 550538001177 HMMPfam hit to PF00889, Translation elongation factor EFTs/EF1B, dimerisation, score 2.8e-108 550538001178 PS01127 Elongation factor Ts signature 2. 550538001179 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 550538001180 putative nucleotide binding site [chemical binding]; other site 550538001181 uridine monophosphate binding site [chemical binding]; other site 550538001182 homohexameric interface [polypeptide binding]; other site 550538001183 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.4e-63 550538001184 ribosome recycling factor; Reviewed; Region: frr; PRK00083 550538001185 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 550538001186 hinge region; other site 550538001187 HMMPfam hit to PF01765, Ribosome recycling factor, score 3.1e-101 550538001188 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 550538001189 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 550538001190 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 550538001191 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 550538001192 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal, score 2.2e-80 550538001193 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001194 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001195 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal, score 1.7e-60 550538001196 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 550538001197 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 550538001198 catalytic residue [active] 550538001199 putative FPP diphosphate binding site; other site 550538001200 putative FPP binding hydrophobic cleft; other site 550538001201 dimer interface [polypeptide binding]; other site 550538001202 putative IPP diphosphate binding site; other site 550538001203 HMMPfam hit to PF01255, Di-trans-poly-cis-decaprenylcistransferase, score 2.9e-149 550538001204 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 550538001205 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 550538001206 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 550538001207 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 3.7e-85 550538001208 8 probable transmembrane helices predicted for SG0226 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143, 150-172, 192-211, 218-240 and 260-282 550538001209 PS01315 Phosphatidate cytidylyltransferase signature. 550538001210 zinc metallopeptidase RseP; Provisional; Region: PRK10779 550538001211 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 550538001212 active site 550538001213 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 550538001214 protein binding site [polypeptide binding]; other site 550538001215 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 550538001216 protein binding site [polypeptide binding]; other site 550538001217 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 550538001218 putative substrate binding region [chemical binding]; other site 550538001219 4 probable transmembrane helices predicted for SG0227 by TMHMM2.0 at aa 2-21, 98-120, 376-398 and 426-445 550538001220 HMMPfam hit to PF02163, Peptidase M50, score 4.3e-95 550538001221 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538001222 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 4.8e-13 550538001223 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 550538001224 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 550538001225 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 550538001226 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 550538001227 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 550538001228 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 550538001229 Surface antigen; Region: Bac_surface_Ag; pfam01103 550538001230 HMMPfam hit to PF07244, Surface antigen variable number, score 1.1e-11 550538001231 HMMPfam hit to PF07244, Surface antigen variable number, score 3.1e-16 550538001232 HMMPfam hit to PF07244, Surface antigen variable number, score 1.2e-18 550538001233 HMMPfam hit to PF07244, Surface antigen variable number, score 2.6e-16 550538001234 HMMPfam hit to PF07244, Surface antigen variable number, score 4.1e-21 550538001235 HMMPfam hit to PF01103, Bacterial surface antigen (D15), score 6.2e-78 550538001236 periplasmic chaperone; Provisional; Region: PRK10780 550538001237 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 550538001238 HMMPfam hit to PF03938, Outer membrane chaperone Skp (OmpH), score 3.3e-36 550538001239 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 550538001240 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 550538001241 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 550538001242 trimer interface [polypeptide binding]; other site 550538001243 active site 550538001244 UDP-GlcNAc binding site [chemical binding]; other site 550538001245 lipid binding site [chemical binding]; lipid-binding site 550538001246 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD, score 1.7e-32 550538001247 PS00101 Hexapeptide-repeat containing-transferases signature. 550538001248 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.37 550538001249 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.011 550538001250 PS00101 Hexapeptide-repeat containing-transferases signature. 550538001251 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.033 550538001252 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.14 550538001253 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.3 550538001254 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.021 550538001255 PS00101 Hexapeptide-repeat containing-transferases signature. 550538001256 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1 550538001257 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 16 550538001258 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 550538001259 HMMPfam hit to PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ, score 8.1e-67 550538001260 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 550538001261 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 550538001262 active site 550538001263 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.0012 550538001264 PS00101 Hexapeptide-repeat containing-transferases signature. 550538001265 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.5 550538001266 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 3.4 550538001267 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 7.5 550538001268 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 85 550538001269 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.67 550538001270 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.2 550538001271 PS00101 Hexapeptide-repeat containing-transferases signature. 550538001272 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 550538001273 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 550538001274 HMMPfam hit to PF02684, Glycosyl transferase, family 19, score 1.7e-219 550538001275 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 550538001276 RNA/DNA hybrid binding site [nucleotide binding]; other site 550538001277 active site 550538001278 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 6.7e-94 550538001279 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 550538001280 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 550538001281 putative active site [active] 550538001282 putative PHP Thumb interface [polypeptide binding]; other site 550538001283 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 550538001284 generic binding surface II; other site 550538001285 generic binding surface I; other site 550538001286 HMMPfam hit to PF02811, PHP, C-terminal, score 7.9e-61 550538001287 HMMPfam hit to PF07733, Bacterial DNA polymerase III, alpha subunit, score 0 550538001288 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 7.9e-13 550538001289 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 550538001290 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 550538001291 HMMPfam hit to PF03255, Acetyl-CoA carboxylase, alpha subunit, score 6.4e-102 550538001292 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 550538001293 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 550538001294 putative sugar binding site [chemical binding]; other site 550538001295 catalytic residues [active] 550538001296 PKD domain; Region: PKD; pfam00801 550538001297 HMMPfam hit to PF00182, Glycoside hydrolase, family 19, catalytic, score 2.2e-29 550538001298 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001299 HMMPfam hit to PF00801, PKD, score 5.3e-08 550538001300 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 0.042 550538001301 lysine decarboxylase LdcC; Provisional; Region: PRK15399 550538001302 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 550538001303 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 550538001304 homodimer interface [polypeptide binding]; other site 550538001305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538001306 catalytic residue [active] 550538001307 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 550538001308 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 1.5e-39 550538001309 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 1.4e-288 550538001310 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 550538001311 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 4.3e-85 550538001312 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 550538001313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 550538001314 putative metal binding site [ion binding]; other site 550538001315 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 1.3e-30 550538001316 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 550538001317 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 550538001318 TilS substrate binding domain; Region: TilS; pfam09179 550538001319 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 550538001320 HMMPfam hit to PF01171, PP-loop, score 9.8e-74 550538001321 HMMPfam hit to PF09179, Protein of unkown function DUF1946, PP-loop ATpase, score 2.5e-94 550538001322 Rho-binding antiterminator; Provisional; Region: PRK11625 550538001323 HMMPfam hit to PF07073, Modulator of Rho-dependent transcription termination, score 9.9e-45 550538001324 hypothetical protein; Provisional; Region: PRK04964 550538001325 HMMPfam hit to PF06786, Protein of unknown function UPF0253, score 7e-42 550538001326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 550538001327 HMMPfam hit to PF07152, YaeQ, score 1.2e-128 550538001328 hypothetical protein; Provisional; Region: PRK09256 550538001329 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 550538001330 HMMPfam hit to PF00472, Class I peptide chain release factor, score 1.7e-36 550538001331 PS00745 Prokaryotic-type class I peptide chain release factors signature. 550538001332 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 550538001333 NlpE N-terminal domain; Region: NlpE; pfam04170 550538001334 HMMPfam hit to PF04170, Copper resistance lipoprotein NlpE, score 2e-115 550538001335 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001336 PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature. 550538001337 prolyl-tRNA synthetase; Provisional; Region: PRK09194 550538001338 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 550538001339 dimer interface [polypeptide binding]; other site 550538001340 motif 1; other site 550538001341 active site 550538001342 motif 2; other site 550538001343 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 550538001344 putative deacylase active site [active] 550538001345 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 550538001346 active site 550538001347 motif 3; other site 550538001348 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 550538001349 anticodon binding site; other site 550538001350 HMMPfam hit to PF03129, Anticodon-binding, score 1e-26 550538001351 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 9.8e-08 550538001352 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 1.3e-66 550538001353 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538001354 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 550538001355 homodimer interaction site [polypeptide binding]; other site 550538001356 cofactor binding site; other site 550538001357 HMMPfam hit to PF01980, Protein of unknown function UPF0066, score 2.1e-54 550538001358 PS01318 Uncharacterized protein family UPF0066 signature. 550538001359 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 550538001360 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001361 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 550538001362 lipoprotein, YaeC family; Region: TIGR00363 550538001363 HMMPfam hit to PF03180, NLPA lipoprotein, score 3.2e-151 550538001364 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538001366 dimer interface [polypeptide binding]; other site 550538001367 conserved gate region; other site 550538001368 ABC-ATPase subunit interface; other site 550538001369 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.1e-21 550538001370 5 probable transmembrane helices predicted for SG0250 by TMHMM2.0 at aa 20-42, 55-77, 81-103, 144-166 and 181-203 550538001371 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538001372 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 550538001373 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 550538001374 Walker A/P-loop; other site 550538001375 ATP binding site [chemical binding]; other site 550538001376 Q-loop/lid; other site 550538001377 ABC transporter signature motif; other site 550538001378 Walker B; other site 550538001379 D-loop; other site 550538001380 H-loop/switch region; other site 550538001381 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 550538001382 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-74 550538001383 PS00211 ABC transporters family signature. 550538001384 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001385 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 550538001386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538001387 active site 550538001388 motif I; other site 550538001389 motif II; other site 550538001390 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.2e-08 550538001391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538001392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538001393 active site 550538001394 catalytic tetrad [active] 550538001395 HMMPfam hit to PF00248, Aldo/keto reductase, score 8.7e-87 550538001396 PS00798 Aldo/keto reductase family signature 1. 550538001397 PS00062 Aldo/keto reductase family signature 2. 550538001398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538001399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538001400 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 550538001401 putative effector binding pocket; other site 550538001402 dimerization interface [polypeptide binding]; other site 550538001403 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.9e-50 550538001404 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.9e-20 550538001405 PS00044 Bacterial regulatory proteins, lysR family signature. 550538001406 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 550538001407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538001408 putative substrate translocation pore; other site 550538001409 12 probable transmembrane helices predicted for SG0255 by TMHMM2.0 at aa 7-29, 39-61, 70-89, 99-121, 128-150, 160-182, 202-224, 234-256, 263-285, 289-311, 332-354 and 358-380 550538001410 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.4e-44 550538001411 hypothetical protein; Provisional; Region: PRK05421 550538001412 putative catalytic site [active] 550538001413 putative metal binding site [ion binding]; other site 550538001414 putative phosphate binding site [ion binding]; other site 550538001415 putative catalytic site [active] 550538001416 putative phosphate binding site [ion binding]; other site 550538001417 putative metal binding site [ion binding]; other site 550538001418 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 3.6e-23 550538001419 Methyltransferase domain; Region: Methyltransf_23; pfam13489 550538001420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538001421 S-adenosylmethionine binding site [chemical binding]; other site 550538001422 HMMPfam hit to PF08241, Methyltransferase type 11, score 5.5e-34 550538001423 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 550538001424 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538001425 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538001426 catalytic residue [active] 550538001427 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538001428 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538001429 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.5e-13 550538001430 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 3.3e-17 550538001431 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 6.7e-38 550538001432 PS00922 Prokaryotic transglycosylases signature. 550538001433 HMMPfam hit to PF06474, MLTD-N, score 4.1e-40 550538001434 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001435 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 550538001436 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.7e-38 550538001437 Methyltransferase domain; Region: Methyltransf_23; pfam13489 550538001438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538001439 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.9e-09 550538001440 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 550538001441 RNA/DNA hybrid binding site [nucleotide binding]; other site 550538001442 active site 550538001443 HMMPfam hit to PF00075, Ribonuclease H, score 1.9e-72 550538001444 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 550538001445 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 550538001446 active site 550538001447 catalytic site [active] 550538001448 substrate binding site [chemical binding]; other site 550538001449 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 3.5e-52 550538001450 Salmonella Pathogenicity Island 6: SPI-6 degenerate 550538001451 Methyltransferase domain; Region: Methyltransf_27; pfam13708 550538001452 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571 550538001453 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 550538001454 HMMPfam hit to PF06154, YagBYeeUYfjZ, score 7.8e-77 550538001455 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 550538001456 Protein of unknown function (DUF987); Region: DUF987; pfam06174 550538001457 HMMPfam hit to PF06174, Protein of unknown function DUF987, score 6.4e-42 550538001458 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 550538001459 MPN+ (JAMM) motif; other site 550538001460 Zinc-binding site [ion binding]; other site 550538001461 HMMPfam hit to PF04002, DNA repair protein RadC, score 3.2e-73 550538001462 Antirestriction protein; Region: Antirestrict; pfam03230 550538001463 HMMPfam hit to PF03230, Antirestriction protein, score 2.2e-46 550538001464 Z1 domain; Region: Z1; pfam10593 550538001465 Domain of unknown function (DUF932); Region: DUF932; pfam06067 550538001466 HMMPfam hit to PF06067, Protein of unknown function DUF932, score 5.5e-198 550538001467 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 550538001468 HMMPfam hit to PF06006, Protein of unknown function DUF905, proteobacteria, score 2e-34 550538001469 2 probable transmembrane helices predicted for SG0277 by TMHMM2.0 at aa 7-29 and 64-86 550538001470 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 550538001471 4 probable transmembrane helices predicted for SG0278 by TMHMM2.0 at aa 71-93, 103-125, 138-152 and 162-178 550538001472 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001473 Predicted transcriptional regulator [Transcription]; Region: COG2378 550538001474 Stage III sporulation protein D; Region: SpoIIID; cl17560 550538001475 WYL domain; Region: WYL; pfam13280 550538001476 PS00894 Bacterial regulatory proteins, deoR family signature. 550538001477 note the premature stop codon following codon 133 550538001478 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.7e-18 550538001482 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 550538001483 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 550538001486 HMMPfam hit to PF00004, AAA ATPase, core, score 3e-09 550538001488 HMMPfam hit to PF03527, RHS protein, score 2.9e-07 550538001489 the sequence has been checked and is believed to be correct 550538001490 the sequence has been checked and is believed to be correct 550538001491 HMMPfam hit to PF08845, Protein of unknown function DUF1813, HSP20-like, score 0.00013 550538001492 the sequence has been checked and is believed to be correct 550538001493 2 probable transmembrane helices predicted for SG0302 by TMHMM2.0 at aa 7-24 and 39-57 550538001494 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 550538001495 1 probable transmembrane helix predicted for SG0303 by TMHMM2.0 at aa 7-29 550538001496 the sequence has been checked and is believed to be correct 550538001498 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.6e-06 550538001499 the sequence has been checked and is believed to be correct 550538001500 HMMPfam hit to PF00665, Integrase, catalytic core, score 4.4e-15 550538001501 fimbrial operon saf 550538001502 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 550538001503 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001504 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 550538001505 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538001506 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538001507 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1.8e-55 550538001508 PS00635 Gram-negative pili assembly chaperone signature. 550538001509 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.7e-23 550538001511 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538001512 putative pilin structural protein SafD; Provisional; Region: PRK15222 550538001513 HMMPfam hit to PF05775, Enterobacteria AfaD invasin, score 8.4e-90 550538001514 1 probable transmembrane helix predicted for SG0312 by TMHMM2.0 at aa 12-31 550538001515 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 550538001516 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 550538001517 putative active site [active] 550538001518 putative metal binding site [ion binding]; other site 550538001519 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 2e-30 550538001521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538001522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538001523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538001524 dimerization interface [polypeptide binding]; other site 550538001525 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.7e-16 550538001526 PS00044 Bacterial regulatory proteins, lysR family signature. 550538001527 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.3e-15 550538001528 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 550538001529 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 550538001530 dimer interface [polypeptide binding]; other site 550538001531 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.0018 550538001532 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.0022 550538001533 C-N hydrolase family amidase; Provisional; Region: PRK10438 550538001534 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 550538001535 putative active site [active] 550538001536 catalytic triad [active] 550538001537 dimer interface [polypeptide binding]; other site 550538001538 multimer interface [polypeptide binding]; other site 550538001539 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 8.3e-09 550538001540 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 550538001541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 550538001542 active site 550538001543 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 550538001544 HMMPfam hit to PF09317, Protein of unknown function DUF1974, score 1.8e-185 550538001545 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 1.9e-08 550538001546 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 0.00017 550538001547 2 probable transmembrane helices predicted for SG0320 by TMHMM2.0 at aa 10-32 and 39-61 550538001548 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 550538001549 dimer interface [polypeptide binding]; other site 550538001550 active site 550538001551 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.8e-06 550538001552 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 550538001553 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 550538001554 putative active site [active] 550538001555 putative dimer interface [polypeptide binding]; other site 550538001556 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 6.4e-39 550538001557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 550538001558 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 550538001559 HMMPfam hit to PF06104, Protein of unknown function DUF949, bacterial, score 2e-146 550538001560 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 550538001561 active site 550538001562 DNA polymerase IV; Validated; Region: PRK02406 550538001563 DNA binding site [nucleotide binding] 550538001564 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 1.3e-136 550538001565 hypothetical protein; Reviewed; Region: PRK09588 550538001566 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 550538001567 HMMPfam hit to PF01139, Protein of unknown function UPF0027, score 3.1e-117 550538001568 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 550538001569 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 550538001570 HMMPfam hit to PF00472, Class I peptide chain release factor, score 5.2e-18 550538001571 PS00745 Prokaryotic-type class I peptide chain release factors signature. 550538001572 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 550538001573 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 550538001574 metal binding site [ion binding]; metal-binding site 550538001575 dimer interface [polypeptide binding]; other site 550538001576 HMMPfam hit to PF01546, Peptidase M20, score 2e-11 550538001577 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 1.3e-16 550538001578 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538001579 active site 550538001580 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 3.1e-19 550538001581 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538001582 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 550538001583 HMMPfam hit to PF06500, Protein of unknown function DUF1100, hydrolase-like, score 1.7e-297 550538001584 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 550538001585 HMMPfam hit to PF07417, Transcriptional regulator Crl, score 6.4e-93 550538001586 the sequence has been checked and is believed to be correct 550538001587 HMMPfam hit to PF00267, Porin, Gram-negative type, score 1.2e-192 550538001588 gamma-glutamyl kinase; Provisional; Region: PRK05429 550538001589 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 550538001590 nucleotide binding site [chemical binding]; other site 550538001591 homotetrameric interface [polypeptide binding]; other site 550538001592 putative phosphate binding site [ion binding]; other site 550538001593 putative allosteric binding site; other site 550538001594 PUA domain; Region: PUA; pfam01472 550538001595 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.5e-59 550538001596 PS00902 Glutamate 5-kinase signature. 550538001597 HMMPfam hit to PF01472, PUA, score 3.9e-29 550538001598 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 550538001599 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 550538001600 putative catalytic cysteine [active] 550538001601 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 8.8e-07 550538001602 PS01223 Gamma-glutamyl phosphate reductase signature. 550538001604 Transposase; Region: HTH_Tnp_1; cl17663 550538001605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 550538001606 HMMPfam hit to PF01527, Transposase IS3/IS911, score 9.3e-11 550538001607 The upstream insertion of an IS3 element has resulted in the deletion of the 5' end of this CDS; HMMPfam hit to PF08841, Diol/glycerol dehydratase reactivating factor, large subunit, score 7.7e-63 550538001608 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 550538001609 HMMPfam hit to PF08986, Protein of unknown function DUF1889, score 1.1e-55 550538001610 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 550538001611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538001612 putative substrate translocation pore; other site 550538001613 12 probable transmembrane helices predicted for SG0338 by TMHMM2.0 at aa 26-48, 68-90, 97-119, 123-145, 152-174, 184-206, 236-258, 268-290, 297-319, 323-345, 362-384 and 388-410 550538001614 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.7e-40 550538001615 PS00216 Sugar transport proteins signature 1. 550538001616 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 550538001617 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 550538001618 substrate binding site [chemical binding]; other site 550538001619 ligand binding site [chemical binding]; other site 550538001620 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 1.7e-185 550538001621 PS00450 Aconitase family signature 1. 550538001622 PS01244 Aconitase family signature 2. 550538001623 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 550538001624 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 550538001625 hypothetical protein; Provisional; Region: PRK14812 550538001626 substrate binding site [chemical binding]; other site 550538001627 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 1.9e-33 550538001628 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 550538001629 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 550538001630 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 4e-41 550538001631 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 550538001632 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 4.4e-20 550538001633 transcriptional activator TtdR; Provisional; Region: PRK09801 550538001634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538001635 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 550538001636 putative effector binding pocket; other site 550538001637 putative dimerization interface [polypeptide binding]; other site 550538001638 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.3e-15 550538001639 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.7e-37 550538001640 fimbrial operon stb 550538001641 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 550538001642 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538001643 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538001644 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 2e-08 550538001645 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 2.9e-31 550538001646 PS00635 Gram-negative pili assembly chaperone signature. 550538001647 1 probable transmembrane helix predicted for SG0346 by TMHMM2.0 at aa 7-29 550538001648 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 550538001649 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.017 550538001650 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001652 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 2.2e-221 550538001653 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 550538001654 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538001655 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538001656 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.5e-07 550538001657 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 4e-49 550538001658 PS00635 Gram-negative pili assembly chaperone signature. 550538001659 1 probable transmembrane helix predicted for SG0349 by TMHMM2.0 at aa 9-31 550538001660 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 550538001661 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.1e-20 550538001663 the sequence has been checked and is believed to be correct 550538001664 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 550538001665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538001666 2 probable transmembrane helices predicted for SG0354 by TMHMM2.0 at aa 7-29 and 223-245 550538001667 HMMPfam hit to PF00563, EAL, score 2.8e-98 550538001668 PS00136 Serine proteases, subtilase family, aspartic acid active site. 550538001669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 550538001670 DNA binding site [nucleotide binding] 550538001671 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 7.2e-08 550538001672 1 probable transmembrane helix predicted for SG0356 by TMHMM2.0 at aa 7-29 550538001673 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 550538001674 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 1.6e-12 550538001675 1 probable transmembrane helix predicted for SG0357 by TMHMM2.0 at aa 5-22 550538001676 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 550538001677 DNA binding residues [nucleotide binding] 550538001678 dimerization interface [polypeptide binding]; other site 550538001679 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 550538001680 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001681 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 550538001682 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.7e-44 550538001683 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.5e-35 550538001684 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001685 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 550538001686 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 550538001687 12 probable transmembrane helices predicted for SG0362 by TMHMM2.0 at aa 7-29, 339-361, 368-390, 394-416, 443-465, 475-497, 543-565, 882-899, 906-928, 933-955, 983-1005 and 1015-1037 550538001688 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538001689 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 550538001690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538001691 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538001692 HMMPfam hit to PF00529, Secretion protein HlyD, score 3.2e-35 550538001693 1 probable transmembrane helix predicted for SG0363 by TMHMM2.0 at aa 7-29 550538001694 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 550538001695 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 550538001696 metal-binding site [ion binding] 550538001697 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 550538001698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538001699 motif II; other site 550538001700 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 5.3e-20 550538001701 PS01047 Heavy-metal-associated domain. 550538001702 8 probable transmembrane helices predicted for SG0364 by TMHMM2.0 at aa 99-121, 136-156, 169-191, 201-219, 353-375, 380-402, 696-718 and 722-744 550538001703 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 4.1e-102 550538001704 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.2e-36 550538001705 PS00154 E1-E2 ATPases phosphorylation site. 550538001706 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 550538001707 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 550538001708 DNA binding residues [nucleotide binding] 550538001709 dimer interface [polypeptide binding]; other site 550538001710 copper binding site [ion binding]; other site 550538001711 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 1.6e-13 550538001712 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 7.5e-27 550538001713 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 550538001714 metal-binding site [ion binding] 550538001715 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 0.0014 550538001716 putative sialic acid transporter; Region: 2A0112; TIGR00891 550538001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538001718 putative substrate translocation pore; other site 550538001719 10 probable transmembrane helices predicted for SG0367 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-127, 140-162, 172-194, 215-232, 252-274, 287-309 and 370-392 550538001720 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5.6e-39 550538001721 PS00217 Sugar transport proteins signature 2. 550538001723 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 1.1e-94 550538001724 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 550538001725 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 550538001726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 550538001727 VRR-NUC domain; Region: VRR_NUC; pfam08774 550538001728 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 2.9e-46 550538001729 HMMPfam hit to PF08774, VRR-NUC, score 3.8e-06 550538001730 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 550538001731 HMMPfam hit to PF01654, Cytochrome bd ubiquinol oxidase, subunit I, score 5.6e-235 550538001732 9 probable transmembrane helices predicted for SG0371 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 126-148, 185-207, 220-237, 322-344, 357-379 and 407-429 550538001733 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 550538001734 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 550538001735 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 550538001736 HMMPfam hit to PF02322, Cytochrome bd ubiquinol oxidase, subunit II, score 2.4e-148 550538001737 8 probable transmembrane helices predicted for SG0372 by TMHMM2.0 at aa 7-26, 78-100, 121-143, 158-180, 193-215, 230-248, 261-283 and 303-325 550538001739 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00013 550538001740 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00017 550538001741 the sequence has been checked and is believed to be correct 550538001742 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 5.2e-26 550538001743 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 7.6e-28 550538001744 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 550538001745 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 9.1e-68 550538001746 6 probable transmembrane helices predicted for SG0377 by TMHMM2.0 at aa 5-27, 39-61, 71-90, 123-140, 150-167 and 187-204 550538001747 hypothetical protein; Provisional; Region: PRK09929 550538001748 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 5e-14 550538001749 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 550538001750 Propionate catabolism activator; Region: PrpR_N; pfam06506 550538001751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538001752 Walker A motif; other site 550538001753 ATP binding site [chemical binding]; other site 550538001754 Walker B motif; other site 550538001755 arginine finger; other site 550538001756 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 550538001757 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 4.3e-11 550538001758 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538001759 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.8e-127 550538001760 PS00134 Serine proteases, trypsin family, histidine active site. 550538001761 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538001762 HMMPfam hit to PF06506, Propionate catabolism activator, N-terminal, score 4.5e-104 550538001763 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 550538001764 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 550538001765 tetramer interface [polypeptide binding]; other site 550538001766 active site 550538001767 Mg2+/Mn2+ binding site [ion binding]; other site 550538001768 HMMPfam hit to PF00463, Isocitrate lyase and phosphorylmutase, score 1.4e-08 550538001769 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 550538001770 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 550538001771 dimer interface [polypeptide binding]; other site 550538001772 active site 550538001773 citrylCoA binding site [chemical binding]; other site 550538001774 oxalacetate/citrate binding site [chemical binding]; other site 550538001775 coenzyme A binding site [chemical binding]; other site 550538001776 catalytic triad [active] 550538001777 HMMPfam hit to PF00285, Citrate synthase, score 3.7e-101 550538001778 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001779 PS00480 Citrate synthase signature. 550538001780 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 550538001781 2-methylcitrate dehydratase; Region: prpD; TIGR02330 550538001782 HMMPfam hit to PF03972, MmgE/PrpD, score 2.7e-242 550538001783 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 550538001784 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 550538001785 acyl-activating enzyme (AAE) consensus motif; other site 550538001786 AMP binding site [chemical binding]; other site 550538001787 active site 550538001788 CoA binding site [chemical binding]; other site 550538001789 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 4e-111 550538001790 PS00455 AMP-binding domain signature. 550538001791 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 550538001792 dimer interface [polypeptide binding]; other site 550538001793 active site 550538001794 Schiff base residues; other site 550538001795 HMMPfam hit to PF00490, Tetrapyrrole biosynthesis, porphobilinogen synthase, score 1.6e-224 550538001796 PS00169 Delta-aminolevulinic acid dehydratase active site. 550538001797 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 550538001798 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 550538001799 Autotransporter beta-domain; Region: Autotransporter; pfam03797 550538001800 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.9e-32 550538001801 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 550538001802 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 550538001803 ligand binding site [chemical binding]; other site 550538001804 flexible hinge region; other site 550538001805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 550538001806 DNA-binding site [nucleotide binding]; DNA binding site 550538001807 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 9.9e-08 550538001808 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 550538001809 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 550538001810 HMMPfam hit to PF00144, Beta-lactamase, score 3.7e-71 550538001811 microcin B17 transporter; Reviewed; Region: PRK11098 550538001812 6 probable transmembrane helices predicted for SG0388 by TMHMM2.0 at aa 23-45, 52-74, 104-126, 172-194, 209-231 and 299-321 550538001813 HMMPfam hit to PF05992, SbmABacA-like, score 8.6e-242 550538001814 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 550538001815 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001816 HMMPfam hit to PF07759, Protein of unknown function DUF1615, score 9e-244 550538001817 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001818 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 550538001819 2 probable transmembrane helices predicted for SG0390 by TMHMM2.0 at aa 25-47 and 68-90 550538001820 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 550538001821 2 probable transmembrane helices predicted for SG0391 by TMHMM2.0 at aa 13-32 and 37-59 550538001822 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 550538001823 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 550538001824 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 550538001825 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 1.5e-124 550538001826 PS00844 D-alanine--D-alanine ligase signature 2. 550538001827 HMMPfam hit to PF01820, D-alanine--D-alanine ligase, N-terminal, score 2.1e-83 550538001828 PS00843 D-alanine--D-alanine ligase signature 1. 550538001829 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 550538001831 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 550538001832 1 probable transmembrane helix predicted for SG0393 by TMHMM2.0 at aa 13-35 550538001833 HMMPfam hit to PF06904, Extensin-like, C-terminal, score 1.5e-70 550538001834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538001835 putative substrate translocation pore; other site 550538001836 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.1e-45 550538001837 9 probable transmembrane helices predicted for SG0394 by TMHMM2.0 at aa 5-24, 37-59, 116-138, 159-181, 204-226, 238-257, 262-284, 297-319 and 324-346 550538001838 anti-RssB factor; Provisional; Region: PRK10244 550538001839 hypothetical protein; Provisional; Region: PRK11505 550538001840 psiF repeat; Region: PsiF_repeat; pfam07769 550538001841 psiF repeat; Region: PsiF_repeat; pfam07769 550538001842 1 probable transmembrane helix predicted for SG0396 by TMHMM2.0 at aa 5-22 550538001843 HMMPfam hit to PF07769, PsiF, score 4.4e-18 550538001844 HMMPfam hit to PF07769, PsiF, score 5.6e-22 550538001845 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 550538001846 MASE2 domain; Region: MASE2; pfam05230 550538001847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538001848 metal binding site [ion binding]; metal-binding site 550538001849 active site 550538001850 I-site; other site 550538001851 HMMPfam hit to PF05230, MASE2, score 2.3e-118 550538001852 4 probable transmembrane helices predicted for SG0397 by TMHMM2.0 at aa 45-67, 105-127, 140-162 and 177-199 550538001853 HMMPfam hit to PF00990, GGDEF, score 1.8e-65 550538001854 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 550538001855 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 550538001856 HMMPfam hit to PF03807, NADP oxidoreductase, coenzyme F420-dependent, score 7.4e-99 550538001857 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 550538001858 note that in comparison to S. enteritidis PT4 this CDS has suffered a deletion event following codon 50 550538001859 HMMPfam hit to PF02639, Protein of unknown function DUF188, score 3e-29 550538001860 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 550538001861 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 550538001862 ADP binding site [chemical binding]; other site 550538001863 magnesium binding site [ion binding]; other site 550538001864 putative shikimate binding site; other site 550538001865 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001866 HMMPfam hit to PF01202, Shikimate kinase, score 1.5e-67 550538001867 PS01128 Shikimate kinase signature. 550538001868 hypothetical protein; Provisional; Region: PRK10380 550538001869 hypothetical protein; Provisional; Region: PRK10481 550538001870 HMMPfam hit to PF07302, AroM, score 6.2e-147 550538001871 hypothetical protein; Provisional; Region: PRK10579 550538001872 HMMPfam hit to PF06865, Protein of unknown function DUF1255, score 4.2e-62 550538001873 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 550538001874 HMMPfam hit to PF04381, exonuclease, RdgC, score 3.5e-213 550538001875 fructokinase; Reviewed; Region: PRK09557 550538001876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538001877 nucleotide binding site [chemical binding]; other site 550538001878 HMMPfam hit to PF00480, ROK, score 2.3e-92 550538001879 PS01125 ROK family signature. 550538001880 MFS transport protein AraJ; Provisional; Region: PRK10091 550538001881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538001882 putative substrate translocation pore; other site 550538001883 12 probable transmembrane helices predicted for SG0406 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 103-120, 125-147, 157-179, 200-222, 237-254, 266-288, 293-315, 320-342 and 352-374 550538001884 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 8.6e-47 550538001885 exonuclease subunit SbcC; Provisional; Region: PRK10246 550538001886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538001887 Walker A/P-loop; other site 550538001888 ATP binding site [chemical binding]; other site 550538001889 Q-loop/lid; other site 550538001890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538001891 ABC transporter signature motif; other site 550538001892 Walker B; other site 550538001893 D-loop; other site 550538001894 H-loop/switch region; other site 550538001895 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1.6e-06 550538001896 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001897 PS00017 ATP/GTP-binding site motif A (P-loop). 550538001898 exonuclease subunit SbcD; Provisional; Region: PRK10966 550538001899 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 550538001900 active site 550538001901 metal binding site [ion binding]; metal-binding site 550538001902 DNA binding site [nucleotide binding] 550538001903 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 550538001904 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.1e-20 550538001905 transcriptional regulator PhoB; Provisional; Region: PRK10161 550538001906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538001907 active site 550538001908 phosphorylation site [posttranslational modification] 550538001909 intermolecular recognition site; other site 550538001910 dimerization interface [polypeptide binding]; other site 550538001911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538001912 DNA binding site [nucleotide binding] 550538001913 HMMPfam hit to PF00072, Response regulator receiver, score 3e-39 550538001914 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 9.9e-24 550538001915 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 550538001916 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 550538001917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538001918 putative active site [active] 550538001919 heme pocket [chemical binding]; other site 550538001920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538001921 dimer interface [polypeptide binding]; other site 550538001922 phosphorylation site [posttranslational modification] 550538001923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538001924 ATP binding site [chemical binding]; other site 550538001925 Mg2+ binding site [ion binding]; other site 550538001926 G-X-G motif; other site 550538001927 1 probable transmembrane helix predicted for SG0410 by TMHMM2.0 at aa 12-34 550538001928 HMMPfam hit to PF00989, PAS fold, score 1.8e-17 550538001929 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.6e-24 550538001930 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.2e-42 550538001931 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 550538001932 HMMPfam hit to PF05525, Branched-chain amino acid transport system II carrier protein, score 4e-240 550538001933 12 probable transmembrane helices predicted for SG0411 by TMHMM2.0 at aa 13-35, 41-63, 76-98, 118-140, 147-169, 189-211, 223-245, 276-298, 305-327, 337-359, 371-393 and 408-426 550538001934 putative proline-specific permease; Provisional; Region: proY; PRK10580 550538001935 HMMPfam hit to PF00324, Amino acid permease-associated region, score 2.6e-136 550538001936 12 probable transmembrane helices predicted for SG0412 by TMHMM2.0 at aa 16-34, 44-63, 83-105, 120-142, 154-176, 196-218, 239-261, 276-298, 329-351, 356-378, 399-421 and 426-445 550538001937 PS00218 Amino acid permeases signature. 550538001938 maltodextrin glucosidase; Provisional; Region: PRK10785 550538001939 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 550538001940 homodimer interface [polypeptide binding]; other site 550538001941 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 550538001942 active site 550538001943 homodimer interface [polypeptide binding]; other site 550538001944 catalytic site [active] 550538001945 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.1e-105 550538001946 peroxidase; Provisional; Region: PRK15000 550538001947 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 550538001948 dimer interface [polypeptide binding]; other site 550538001949 decamer (pentamer of dimers) interface [polypeptide binding]; other site 550538001950 catalytic triad [active] 550538001951 peroxidatic and resolving cysteines [active] 550538001952 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 9.5e-47 550538001953 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 550538001954 HMMPfam hit to PF04336, Protein of unknown function DUF479, score 1e-116 550538001955 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 550538001956 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 550538001957 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 1.9e-149 550538001958 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 550538001959 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 550538001960 HMMPfam hit to PF01702, Queuine/other tRNA-ribosyltransferase, score 2e-170 550538001961 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 550538001962 HMMPfam hit to PF02699, YajC, score 4.4e-47 550538001963 1 probable transmembrane helix predicted for SG0418 by TMHMM2.0 at aa 20-39 550538001964 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 550538001965 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 550538001966 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 550538001967 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 550538001968 6 probable transmembrane helices predicted for SG0419 by TMHMM2.0 at aa 7-29, 452-471, 476-498, 503-525, 546-568 and 583-605 550538001969 HMMPfam hit to PF07549, SecD/SecF/SecDF export membrane protein, score 6.5e-05 550538001970 PS00761 Signal peptidases I signature 3. 550538001971 HMMPfam hit to PF02355, SecD/SecF/SecDF export membrane protein, score 5.1e-06 550538001972 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 550538001973 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 550538001974 Protein export membrane protein; Region: SecD_SecF; pfam02355 550538001975 6 probable transmembrane helices predicted for SG0420 by TMHMM2.0 at aa 24-46, 143-162, 169-191, 195-217, 248-270 and 275-297 550538001976 HMMPfam hit to PF07549, SecD/SecF/SecDF export membrane protein, score 0.00021 550538001977 HMMPfam hit to PF02355, SecD/SecF/SecDF export membrane protein, score 4.6e-94 550538001978 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 550538001979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 550538001980 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 6.7e-08 550538001981 Predicted transcriptional regulator [Transcription]; Region: COG2378 550538001982 HTH domain; Region: HTH_11; pfam08279 550538001983 WYL domain; Region: WYL; pfam13280 550538001984 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 4.1e-20 550538001985 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 550538001986 active site 550538001987 HMMPfam hit to PF01844, HNH endonuclease, score 6.2e-06 550538001988 PS00190 Cytochrome c family heme-binding site signature. 550538001989 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 550538001990 HMMPfam hit to PF03502, Nucleoside-specific channel-forming protein, Tsx, score 4.6e-100 550538001991 hypothetical protein; Provisional; Region: PRK11530 550538001992 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538001993 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 550538001994 ATP cone domain; Region: ATP-cone; pfam03477 550538001995 HMMPfam hit to PF03477, ATP-cone, score 2.2e-35 550538001996 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 550538001997 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 550538001998 catalytic motif [active] 550538001999 Zn binding site [ion binding]; other site 550538002000 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 550538002001 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 3.9e-47 550538002002 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 550538002003 HMMPfam hit to PF01872, Bacterial bifunctional deaminase-reductase, C-terminal, score 3.9e-90 550538002004 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 550538002005 homopentamer interface [polypeptide binding]; other site 550538002006 active site 550538002007 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 1.9e-90 550538002008 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 550538002009 putative RNA binding site [nucleotide binding]; other site 550538002010 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 5.7e-50 550538002011 thiamine monophosphate kinase; Provisional; Region: PRK05731 550538002012 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 550538002013 ATP binding site [chemical binding]; other site 550538002014 dimerization interface [polypeptide binding]; other site 550538002015 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 1.9e-10 550538002016 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 550538002017 tetramer interfaces [polypeptide binding]; other site 550538002018 binuclear metal-binding site [ion binding]; other site 550538002019 HMMPfam hit to PF04608, Phosphatidylglycerophosphatase A, score 1.5e-77 550538002020 3 probable transmembrane helices predicted for SG0431 by TMHMM2.0 at aa 21-43, 53-75 and 140-162 550538002021 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538002022 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538002023 active site 550538002024 catalytic tetrad [active] 550538002025 HMMPfam hit to PF00248, Aldo/keto reductase, score 5.3e-66 550538002026 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 550538002027 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 550538002028 TPP-binding site; other site 550538002029 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 550538002030 PYR/PP interface [polypeptide binding]; other site 550538002031 dimer interface [polypeptide binding]; other site 550538002032 TPP binding site [chemical binding]; other site 550538002033 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 550538002034 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1e-37 550538002035 HMMPfam hit to PF02779, Transketolase, central region, score 3.6e-59 550538002036 PS00802 Transketolase signature 2. 550538002037 PS00801 Transketolase signature 1. 550538002038 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 550538002039 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 550538002040 substrate binding pocket [chemical binding]; other site 550538002041 chain length determination region; other site 550538002042 substrate-Mg2+ binding site; other site 550538002043 catalytic residues [active] 550538002044 aspartate-rich region 1; other site 550538002045 active site lid residues [active] 550538002046 aspartate-rich region 2; other site 550538002047 HMMPfam hit to PF00348, Polyprenyl synthetase, score 9.5e-131 550538002048 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002049 PS00444 Polyprenyl synthetases signature 2. 550538002050 PS00723 Polyprenyl synthetases signature 1. 550538002051 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 550538002052 HMMPfam hit to PF02609, Exonuclease VII, small subunit, score 1.8e-33 550538002053 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 550538002054 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 550538002055 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 550538002056 Ligand Binding Site [chemical binding]; other site 550538002057 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 550538002058 active site residue [active] 550538002059 HMMPfam hit to PF02926, THUMP, score 2e-28 550538002060 HMMPfam hit to PF02568, Thiamine biosynthesis protein, score 4.9e-110 550538002061 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 550538002062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538002063 dimer interface [polypeptide binding]; other site 550538002064 conserved gate region; other site 550538002065 putative PBP binding loops; other site 550538002066 ABC-ATPase subunit interface; other site 550538002067 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8e-18 550538002068 6 probable transmembrane helices predicted for SG0437 by TMHMM2.0 at aa 12-34, 66-88, 101-123, 133-155, 191-213 and 233-255 550538002069 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 550538002070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538002071 dimer interface [polypeptide binding]; other site 550538002072 conserved gate region; other site 550538002073 putative PBP binding loops; other site 550538002074 ABC-ATPase subunit interface; other site 550538002075 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.1e-14 550538002076 7 probable transmembrane helices predicted for SG0438 by TMHMM2.0 at aa 15-37, 74-96, 111-133, 140-162, 199-221, 226-245 and 255-277 550538002077 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538002078 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 550538002079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538002080 Walker A/P-loop; other site 550538002081 ATP binding site [chemical binding]; other site 550538002082 Q-loop/lid; other site 550538002083 ABC transporter signature motif; other site 550538002084 Walker B; other site 550538002085 D-loop; other site 550538002086 H-loop/switch region; other site 550538002087 TOBE domain; Region: TOBE_2; pfam08402 550538002088 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 5.8e-18 550538002089 HMMPfam hit to PF00005, ABC transporter related, score 2.4e-60 550538002090 PS00211 ABC transporters family signature. 550538002091 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002092 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 550538002093 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 550538002094 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.2e-15 550538002095 transcriptional regulator protein; Region: phnR; TIGR03337 550538002096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538002097 DNA-binding site [nucleotide binding]; DNA binding site 550538002098 UTRA domain; Region: UTRA; pfam07702 550538002099 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.6e-44 550538002100 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.5e-23 550538002101 PS00043 Bacterial regulatory proteins, gntR family signature. 550538002102 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 550538002103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538002104 catalytic residue [active] 550538002105 HMMPfam hit to PF00266, Aminotransferase, class V, score 1.5e-08 550538002106 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 550538002107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538002108 motif II; other site 550538002109 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.4e-19 550538002110 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 550538002111 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 550538002112 conserved cys residue [active] 550538002113 HMMPfam hit to PF01965, ThiJ/PfpI, score 5.1e-47 550538002114 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 550538002115 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 550538002116 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 550538002117 HMMPfam hit to PF08546, Ketopantoate reductase ApbA/PanE, C-terminal, score 9e-59 550538002118 HMMPfam hit to PF02558, Ketopantoate reductase ApbA/PanE, N-terminal, score 1.4e-37 550538002119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 550538002120 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 550538002121 HMMPfam hit to PF04461, Protein of unknown function DUF520, score 1.7e-112 550538002122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538002123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538002124 putative substrate translocation pore; other site 550538002125 12 probable transmembrane helices predicted for SG0447 by TMHMM2.0 at aa 13-35, 50-72, 79-98, 102-124, 137-159, 164-186, 217-239, 254-273, 280-302, 306-328, 341-363 and 368-385 550538002126 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.8e-46 550538002127 Sel1-like repeats; Region: SEL1; smart00671 550538002128 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538002129 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538002130 Sel1-like repeats; Region: SEL1; smart00671 550538002131 HMMPfam hit to PF08238, Sel1-like, score 0.00019 550538002132 HMMPfam hit to PF08238, Sel1-like, score 0.0082 550538002133 HMMPfam hit to PF08238, Sel1-like, score 0.083 550538002134 HMMPfam hit to PF08238, Sel1-like, score 0.78 550538002135 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538002136 Sel1-like repeats; Region: SEL1; smart00671 550538002137 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538002138 Sel1-like repeats; Region: SEL1; smart00671 550538002139 Sel1-like repeats; Region: SEL1; smart00671 550538002140 HMMPfam hit to PF08238, Sel1-like, score 8.5e-06 550538002141 HMMPfam hit to PF08238, Sel1-like, score 0.5 550538002142 HMMPfam hit to PF08238, Sel1-like, score 0.79 550538002143 HMMPfam hit to PF08238, Sel1-like, score 7.5e-09 550538002144 HMMPfam hit to PF08238, Sel1-like, score 5.4e-06 550538002145 HMMPfam hit to PF08238, Sel1-like, score 1.8 550538002146 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 550538002147 UbiA prenyltransferase family; Region: UbiA; pfam01040 550538002148 9 probable transmembrane helices predicted for SG0450 by TMHMM2.0 at aa 12-34, 38-60, 81-103, 108-127, 134-156, 161-183, 209-231, 235-252 and 264-286 550538002149 HMMPfam hit to PF01040, UbiA prenyltransferase, score 2.3e-90 550538002150 PS00141 Eukaryotic and viral aspartyl proteases active site. 550538002151 PS00943 UbiA prenyltransferase family signature. 550538002152 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002153 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 550538002154 HMMPfam hit to PF03626, Cytochrome C oxidase subunit IV prokaryotic, score 2.2e-50 550538002155 3 probable transmembrane helices predicted for SG0451 by TMHMM2.0 at aa 15-37, 44-66 and 76-98 550538002156 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 550538002157 Subunit III/IV interface [polypeptide binding]; other site 550538002158 Subunit I/III interface [polypeptide binding]; other site 550538002159 HMMPfam hit to PF00510, Cytochrome c oxidase, subunit III, score 3.2e-05 550538002160 5 probable transmembrane helices predicted for SG0452 by TMHMM2.0 at aa 5-24, 34-56, 63-85, 105-127 and 148-170 550538002161 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 550538002162 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 550538002163 D-pathway; other site 550538002164 Putative ubiquinol binding site [chemical binding]; other site 550538002165 Low-spin heme (heme b) binding site [chemical binding]; other site 550538002166 Putative water exit pathway; other site 550538002167 Binuclear center (heme o3/CuB) [ion binding]; other site 550538002168 K-pathway; other site 550538002169 Putative proton exit pathway; other site 550538002170 14 probable transmembrane helices predicted for SG0453 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 456-478, 498-520 and 590-612 550538002171 HMMPfam hit to PF00115, Cytochrome c oxidase, subunit I, score 3.1e-268 550538002172 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 550538002173 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 550538002174 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 550538002175 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 550538002176 HMMPfam hit to PF06481, COX aromatic rich, score 1.8e-16 550538002177 HMMPfam hit to PF00116, Cytochrome c oxidase subunit II C-terminal, score 4e-06 550538002178 3 probable transmembrane helices predicted for SG0454 by TMHMM2.0 at aa 12-30, 45-67 and 88-110 550538002179 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002180 muropeptide transporter; Reviewed; Region: ampG; PRK11902 550538002181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538002182 putative substrate translocation pore; other site 550538002183 14 probable transmembrane helices predicted for SG0455 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 109-131, 144-166, 176-195, 223-245, 260-282, 287-309, 319-341, 354-376, 380-402, 423-445 and 458-480 550538002184 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 7.3e-30 550538002185 hypothetical protein; Provisional; Region: PRK11627 550538002186 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 550538002187 HMMPfam hit to PF03923, Uncharacterized lipoprotein, score 1.7e-07 550538002188 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002189 transcriptional regulator BolA; Provisional; Region: PRK11628 550538002190 HMMPfam hit to PF01722, BolA-like protein, score 2.3e-37 550538002191 trigger factor; Provisional; Region: tig; PRK01490 550538002192 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 550538002193 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 550538002194 HMMPfam hit to PF05697, Bacterial trigger factor, N-terminal, score 4.8e-70 550538002195 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 1.1e-27 550538002196 HMMPfam hit to PF05698, Bacterial trigger factor, C-terminal, score 1.2e-60 550538002197 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 550538002198 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 550538002199 oligomer interface [polypeptide binding]; other site 550538002200 active site residues [active] 550538002201 HMMPfam hit to PF00574, Peptidase S14, ClpP, score 8e-140 550538002202 PS00381 Endopeptidase Clp serine active site. 550538002203 PS00382 Endopeptidase Clp histidine active site. 550538002204 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 550538002205 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 550538002206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538002207 Walker A motif; other site 550538002208 ATP binding site [chemical binding]; other site 550538002209 Walker B motif; other site 550538002210 Iron permease FTR1 family; Region: FTR1; cl00475 550538002211 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 550538002212 HMMPfam hit to PF06689, Zinc finger, C4-type, score 5e-27 550538002213 HMMPfam hit to PF07724, ATPase AAA-2, score 4.7e-81 550538002214 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002215 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 550538002216 Found in ATP-dependent protease La (LON); Region: LON; smart00464 550538002217 Found in ATP-dependent protease La (LON); Region: LON; smart00464 550538002218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538002219 Walker A motif; other site 550538002220 ATP binding site [chemical binding]; other site 550538002221 Walker B motif; other site 550538002222 arginine finger; other site 550538002223 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 550538002224 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 2.6e-84 550538002225 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538002226 HMMPfam hit to PF00004, AAA ATPase, core, score 2.6e-44 550538002227 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002228 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 5.5e-156 550538002229 PS01046 ATP-dependent serine proteases, lon family, serine active site. 550538002230 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 550538002231 IHF dimer interface [polypeptide binding]; other site 550538002232 IHF - DNA interface [nucleotide binding]; other site 550538002233 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 8.3e-47 550538002234 PS00045 Bacterial histone-like DNA-binding proteins signature. 550538002235 periplasmic folding chaperone; Provisional; Region: PRK10788 550538002236 SurA N-terminal domain; Region: SurA_N_3; cl07813 550538002237 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 550538002238 1 probable transmembrane helix predicted for SG0463 by TMHMM2.0 at aa 13-35 550538002239 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 6.3e-16 550538002240 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 550538002241 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 550538002242 the sequence has been checked and is believed to be correct 550538002243 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.4e-13 550538002244 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 550538002245 Ligand Binding Site [chemical binding]; other site 550538002246 HMMPfam hit to PF06508, Exoenzyme S synthesis protein B/queuosine synthesis, score 1.8e-112 550538002247 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 550538002248 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 550538002249 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 550538002250 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 3e-23 550538002251 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 550538002252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538002253 active site 550538002254 motif I; other site 550538002255 motif II; other site 550538002256 PS01228 Hypothetical cof family signature 1. 550538002257 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 3.7e-67 550538002258 PS01229 Hypothetical cof family signature 2. 550538002259 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 550538002260 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 550538002261 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538002262 catalytic residue [active] 550538002263 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1.1e-55 550538002264 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 550538002265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538002266 putative DNA binding site [nucleotide binding]; other site 550538002267 putative Zn2+ binding site [ion binding]; other site 550538002268 AsnC family; Region: AsnC_trans_reg; pfam01037 550538002269 PS00519 Bacterial regulatory proteins, asnC family signature. 550538002270 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 6.8e-29 550538002271 the sequence has been checked and is believed to be correct 550538002272 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 5.2e-32 550538002273 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-58 550538002274 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 550538002275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 550538002276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538002277 Walker A/P-loop; other site 550538002278 ATP binding site [chemical binding]; other site 550538002279 Q-loop/lid; other site 550538002280 ABC transporter signature motif; other site 550538002281 Walker B; other site 550538002282 D-loop; other site 550538002283 H-loop/switch region; other site 550538002284 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.1e-29 550538002285 5 probable transmembrane helices predicted for SG0472 by TMHMM2.0 at aa 12-34, 54-76, 125-147, 152-172 and 236-258 550538002286 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-48 550538002287 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002288 PS00211 ABC transporters family signature. 550538002289 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 550538002290 Nitrogen regulatory protein P-II; Region: P-II; smart00938 550538002291 HMMPfam hit to PF00543, Nitrogen regulatory protein PII, score 4.8e-72 550538002292 PS00496 P-II protein urydylation site. 550538002293 PS00638 P-II protein C-terminal region signature. 550538002294 ammonium transporter; Provisional; Region: PRK10666 550538002295 12 probable transmembrane helices predicted for SG0474 by TMHMM2.0 at aa 9-26, 36-58, 63-85, 120-142, 149-171, 186-205, 218-237, 247-269, 281-303, 307-324, 337-359 and 374-396 550538002296 HMMPfam hit to PF00909, Rh-like protein/ammonium transporter, score 3.4e-187 550538002297 PS01219 Ammonium transporters signature. 550538002298 acyl-CoA thioesterase II; Provisional; Region: PRK10526 550538002299 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 550538002300 active site 550538002301 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 550538002302 catalytic triad [active] 550538002303 dimer interface [polypeptide binding]; other site 550538002304 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 4.6e-78 550538002305 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 3.9e-43 550538002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 550538002307 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002308 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 550538002309 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 550538002310 DNA binding site [nucleotide binding] 550538002311 active site 550538002312 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 3.4e-39 550538002313 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 550538002314 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 550538002315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538002316 HMMPfam hit to PF00563, EAL, score 7.2e-111 550538002317 2 probable transmembrane helices predicted for SG0478 by TMHMM2.0 at aa 6-28 and 243-265 550538002318 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 550538002319 HMMPfam hit to PF01197, Ribosomal protein L31, score 2.3e-11 550538002320 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 550538002321 HMMPfam hit to PF00444, Ribosomal protein L36, score 0.00024 550538002322 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 550538002323 2 probable transmembrane helices predicted for SG0481 by TMHMM2.0 at aa 36-55 and 60-79 550538002324 maltose O-acetyltransferase; Provisional; Region: PRK10092 550538002325 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 550538002326 active site 550538002327 substrate binding site [chemical binding]; other site 550538002328 trimer interface [polypeptide binding]; other site 550538002329 CoA binding site [chemical binding]; other site 550538002330 PS00101 Hexapeptide-repeat containing-transferases signature. 550538002331 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.098 550538002332 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.83 550538002333 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.048 550538002334 gene expression modulator; Provisional; Region: PRK10945 550538002335 HMMPfam hit to PF05321, Haemolysin expression modulating, score 1.4e-37 550538002336 Hha toxicity attenuator; Provisional; Region: PRK10667 550538002337 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 550538002338 Protein export membrane protein; Region: SecD_SecF; cl14618 550538002339 Protein export membrane protein; Region: SecD_SecF; cl14618 550538002340 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 550538002341 11 probable transmembrane helices predicted for SG0485 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 542-564, 873-892, 899-921, 926-948, 975-997 and 1007-1029 550538002342 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002343 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 550538002344 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538002345 HMMPfam hit to PF00529, Secretion protein HlyD, score 4.4e-91 550538002346 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002347 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 550538002348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538002349 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 550538002350 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 3.1e-24 550538002351 PS01081 Bacterial regulatory proteins, tetR family signature. 550538002352 HMMPfam hit to PF08361, Transcriptional regulator, MAATS, C-terminal, score 6.4e-84 550538002353 hypothetical protein; Provisional; Region: PRK11281 550538002354 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 550538002355 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 550538002356 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538002357 12 probable transmembrane helices predicted for SG0488 by TMHMM2.0 at aa 13-32, 500-522, 557-579, 584-606, 630-647, 658-680, 693-715, 725-747, 795-817, 837-859, 880-902 and 917-939 550538002358 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002359 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 6.2e-87 550538002360 PS01246 Uncharacterized protein family UPF0003 signature. 550538002361 Uncharacterized conserved protein [Function unknown]; Region: COG5464 550538002362 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 550538002363 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 7e-164 550538002364 hypothetical protein; Provisional; Region: PRK11038 550538002365 primosomal replication protein N''; Provisional; Region: PRK10093 550538002366 HMMPfam hit to PF07445, Primosomal replication priB and priC, score 7.9e-102 550538002367 hypothetical protein; Provisional; Region: PRK10527 550538002368 3 probable transmembrane helices predicted for SG0492 by TMHMM2.0 at aa 5-27, 75-92 and 99-118 550538002369 HMMPfam hit to PF04304, Protein of unknown function DUF454, score 9.4e-30 550538002370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538002371 active site 550538002372 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 4.2e-51 550538002373 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538002374 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 550538002375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538002376 Walker A motif; other site 550538002377 ATP binding site [chemical binding]; other site 550538002378 Walker B motif; other site 550538002379 DNA polymerase III subunit delta'; Validated; Region: PRK08485 550538002380 arginine finger; other site 550538002381 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 550538002382 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 550538002383 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 550538002384 HMMPfam hit to PF00004, AAA ATPase, core, score 1.9e-11 550538002385 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002386 hypothetical protein; Validated; Region: PRK00153 550538002387 HMMPfam hit to PF02575, Conserved hypothetical protein CHP00103, score 8.5e-53 550538002388 recombination protein RecR; Reviewed; Region: recR; PRK00076 550538002389 RecR protein; Region: RecR; pfam02132 550538002390 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 550538002391 putative active site [active] 550538002392 putative metal-binding site [ion binding]; other site 550538002393 tetramer interface [polypeptide binding]; other site 550538002394 HMMPfam hit to PF02132, Zinc finger C4-type, RecR, score 4.6e-22 550538002395 PS01300 RecR protein signature. 550538002396 HMMPfam hit to PF01751, TOPRIM, score 2.6e-24 550538002397 heat shock protein 90; Provisional; Region: PRK05218 550538002398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538002399 ATP binding site [chemical binding]; other site 550538002400 Mg2+ binding site [ion binding]; other site 550538002401 G-X-G motif; other site 550538002402 PS00298 Heat shock hsp90 proteins family signature. 550538002403 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.2e-17 550538002404 HMMPfam hit to PF00183, Heat shock protein Hsp90, score 2.1e-115 550538002405 adenylate kinase; Reviewed; Region: adk; PRK00279 550538002406 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 550538002407 AMP-binding site [chemical binding]; other site 550538002408 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 550538002409 HMMPfam hit to PF00406, Adenylate kinase, score 3.5e-100 550538002410 PS00113 Adenylate kinase signature. 550538002411 HMMPfam hit to PF05191, Adenylate kinase, lid region, score 1.7e-21 550538002412 ferrochelatase; Reviewed; Region: hemH; PRK00035 550538002413 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 550538002414 C-terminal domain interface [polypeptide binding]; other site 550538002415 active site 550538002416 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 550538002417 active site 550538002418 N-terminal domain interface [polypeptide binding]; other site 550538002419 HMMPfam hit to PF00762, Ferrochelatase, score 8.6e-159 550538002420 PS00534 Ferrochelatase signature. 550538002421 the sequence has been checked and is believed to be correct 550538002422 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 4e-67 550538002423 inosine/guanosine kinase; Provisional; Region: PRK15074 550538002424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538002425 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 4.7e-23 550538002426 PS00584 pfkB family of carbohydrate kinases signature 2. 550538002427 putative cation:proton antiport protein; Provisional; Region: PRK10669 550538002428 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 550538002429 TrkA-N domain; Region: TrkA_N; pfam02254 550538002430 HMMPfam hit to PF02254, TrkA-N, score 1.7e-32 550538002431 12 probable transmembrane helices predicted for SG0503 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 186-208, 229-251, 280-299, 302-324, 339-361 and 368-387 550538002432 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 4.9e-87 550538002433 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538002435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538002436 putative substrate translocation pore; other site 550538002437 10 probable transmembrane helices predicted for SG0504 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 180-202, 223-245, 265-287, 294-313, 317-339, 351-373 and 377-399 550538002438 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.2e-38 550538002439 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 550538002440 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 550538002441 active site 550538002442 metal binding site [ion binding]; metal-binding site 550538002443 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 550538002444 HMMPfam hit to PF00149, Metallophosphoesterase, score 6.8e-15 550538002445 PS00785 5'-nucleotidase signature 1. 550538002446 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 1.7e-54 550538002447 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 550538002448 putative deacylase active site [active] 550538002449 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 1.3e-76 550538002450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 550538002451 HMMPfam hit to PF07446, GumN, score 2.8e-06 550538002452 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 550538002453 copper exporting ATPase; Provisional; Region: copA; PRK10671 550538002454 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 550538002455 metal-binding site [ion binding] 550538002456 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 550538002457 metal-binding site [ion binding] 550538002458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 550538002459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538002460 motif II; other site 550538002461 8 probable transmembrane helices predicted for SG0509 by TMHMM2.0 at aa 188-205, 215-237, 244-266, 281-298, 435-457, 462-484, 777-796 and 801-823 550538002462 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.5e-40 550538002463 PS01229 Hypothetical cof family signature 2. 550538002464 PS00154 E1-E2 ATPases phosphorylation site. 550538002465 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 6.1e-98 550538002466 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 1.5e-14 550538002467 PS01047 Heavy-metal-associated domain. 550538002468 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 2.5e-09 550538002469 PS01047 Heavy-metal-associated domain. 550538002470 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 550538002471 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 550538002472 DNA binding residues [nucleotide binding] 550538002473 dimer interface [polypeptide binding]; other site 550538002474 copper binding site [ion binding]; other site 550538002475 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 4.3e-13 550538002476 PS00552 Bacterial regulatory proteins, merR family signature. 550538002477 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 2.6e-19 550538002478 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 550538002479 HMMPfam hit to PF01957, Nodulation efficiency, NfeD, score 1.2e-33 550538002480 3 probable transmembrane helices predicted for SG0511 by TMHMM2.0 at aa 4-23, 30-49 and 53-75 550538002481 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 550538002482 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 550538002483 HMMPfam hit to PF01145, Band 7 protein, score 3.7e-80 550538002484 PS01270 Band 7 protein family signature. 550538002485 1 probable transmembrane helix predicted for SG0512 by TMHMM2.0 at aa 7-29 550538002486 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 550538002487 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 550538002488 Walker A/P-loop; other site 550538002489 ATP binding site [chemical binding]; other site 550538002490 Q-loop/lid; other site 550538002491 ABC transporter signature motif; other site 550538002492 Walker B; other site 550538002493 D-loop; other site 550538002494 H-loop/switch region; other site 550538002495 HMMPfam hit to PF00005, ABC transporter related, score 8.4e-39 550538002496 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002497 PS00211 ABC transporters family signature. 550538002498 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 550538002499 HMMPfam hit to PF03649, Conserved hypothetical protein CHP00245, score 1.6e-158 550538002500 6 probable transmembrane helices predicted for SG0514 by TMHMM2.0 at aa 7-24, 57-79, 92-114, 118-140, 192-209 and 219-241 550538002501 the sequence has been checked and is believed to be correct 550538002502 HMMPfam hit to PF00085, Thioredoxin domain, score 2.6e-21 550538002503 oxidoreductase; Provisional; Region: PRK08017 550538002504 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 550538002505 NADP binding site [chemical binding]; other site 550538002506 active site 550538002507 steroid binding site; other site 550538002508 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1e-21 550538002509 PS00061 Short-chain dehydrogenases/reductases family signature. 550538002510 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 550538002511 active site 550538002512 catalytic triad [active] 550538002513 oxyanion hole [active] 550538002514 switch loop; other site 550538002515 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 1.3e-35 550538002516 PS01098 Lipolytic enzymes family, serine active site. 550538002517 1 probable transmembrane helix predicted for SG0517 by TMHMM2.0 at aa 7-26 550538002518 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 550538002519 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 550538002520 Walker A/P-loop; other site 550538002521 ATP binding site [chemical binding]; other site 550538002522 Q-loop/lid; other site 550538002523 ABC transporter signature motif; other site 550538002524 Walker B; other site 550538002525 D-loop; other site 550538002526 H-loop/switch region; other site 550538002527 HMMPfam hit to PF00005, ABC transporter related, score 8e-62 550538002528 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002529 PS00211 ABC transporters family signature. 550538002530 the sequence has been checked and is believed to be correct 550538002531 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1.1e-11 550538002532 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 4.5e-08 550538002533 the sequence has been checked and is believed to be correct 550538002534 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 550538002535 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 550538002536 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.5e-113 550538002537 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 550538002538 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 550538002539 Walker A/P-loop; other site 550538002540 ATP binding site [chemical binding]; other site 550538002541 Q-loop/lid; other site 550538002542 ABC transporter signature motif; other site 550538002543 Walker B; other site 550538002544 D-loop; other site 550538002545 H-loop/switch region; other site 550538002546 NIL domain; Region: NIL; pfam09383 550538002547 HMMPfam hit to PF00005, ABC transporter related, score 4.1e-70 550538002548 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002549 PS00211 ABC transporters family signature. 550538002550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538002551 dimer interface [polypeptide binding]; other site 550538002552 conserved gate region; other site 550538002553 ABC-ATPase subunit interface; other site 550538002554 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.1e-20 550538002555 6 probable transmembrane helices predicted for SG0523 by TMHMM2.0 at aa 15-37, 50-72, 82-104, 117-139, 149-171 and 183-205 550538002556 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538002557 Predicted ATPase [General function prediction only]; Region: COG2603 550538002558 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 550538002559 active site residue [active] 550538002560 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002561 note the frame shift mutation following codon 91 550538002562 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.6e-13 550538002563 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.4e-15 550538002564 ureidoglycolate hydrolase; Provisional; Region: PRK03606 550538002565 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 550538002566 HMMPfam hit to PF04115, Ureidoglycolate hydrolase, score 1.4e-90 550538002567 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 550538002568 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 550538002569 Bacterial transcriptional regulator; Region: IclR; pfam01614 550538002570 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 2.8e-22 550538002571 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 3.3e-51 550538002572 PS01051 Bacterial regulatory proteins, iclR family signature. 550538002573 glyoxylate carboligase; Provisional; Region: PRK11269 550538002574 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 550538002575 PYR/PP interface [polypeptide binding]; other site 550538002576 dimer interface [polypeptide binding]; other site 550538002577 TPP binding site [chemical binding]; other site 550538002578 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 550538002579 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 550538002580 TPP-binding site [chemical binding]; other site 550538002581 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 2.2e-53 550538002582 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 1.2e-51 550538002583 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 4.2e-52 550538002584 hydroxypyruvate isomerase; Provisional; Region: PRK09997 550538002585 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 1.3e-53 550538002586 PS00778 Histidine acid phosphatases active site signature. 550538002587 tartronate semialdehyde reductase; Provisional; Region: PRK15059 550538002588 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 550538002589 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 1.8e-67 550538002590 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 550538002591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538002592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538002593 putative substrate translocation pore; other site 550538002594 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.4e-50 550538002595 12 probable transmembrane helices predicted for SG0532 by TMHMM2.0 at aa 20-37, 52-74, 81-98, 103-125, 138-160, 170-192, 220-242, 257-279, 292-310, 320-339, 352-374 and 384-403 550538002596 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 550538002597 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 550538002598 substrate binding site [chemical binding]; other site 550538002599 Na binding site [ion binding]; other site 550538002600 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil, thiamine, allantoin, score 1e-162 550538002601 12 probable transmembrane helices predicted for SG0534 by TMHMM2.0 at aa 7-29, 44-63, 70-92, 107-129, 142-164, 179-201, 221-243, 263-285, 298-320, 330-352, 373-392 and 402-421 550538002602 allantoinase; Provisional; Region: PRK08044 550538002603 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 550538002604 active site 550538002605 HMMPfam hit to PF01979, Amidohydrolase 1, score 2.5e-10 550538002606 putative uracil/xanthine transporter; Provisional; Region: PRK11412 550538002607 PS00430 TonB-dependent receptor proteins signature 1. 550538002608 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 2.7e-98 550538002609 11 probable transmembrane helices predicted for SG0536 by TMHMM2.0 at aa 15-37, 42-64, 99-121, 128-150, 170-189, 196-213, 237-259, 280-302, 341-363, 375-397 and 407-426 550538002610 glycerate kinase II; Provisional; Region: PRK09932 550538002611 HMMPfam hit to PF02595, Glycerate kinase, score 5.7e-247 550538002612 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002613 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 550538002614 Mif2/CENP-C like; Region: Mif2; pfam11699 550538002615 Cupin domain; Region: Cupin_2; pfam07883 550538002616 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 8.7e-05 550538002617 HMMPfam hit to PF05899, Protein of unknown function DUF861, cupin-3, score 4.4e-15 550538002618 allantoate amidohydrolase; Region: AllC; TIGR03176 550538002619 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 550538002620 active site 550538002621 metal binding site [ion binding]; metal-binding site 550538002622 dimer interface [polypeptide binding]; other site 550538002623 HMMPfam hit to PF01546, Peptidase M20, score 5.1e-40 550538002624 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 0.0026 550538002625 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 550538002626 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 7.2e-193 550538002627 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538002628 the sequence has been checked and is believed to be correct 550538002629 HMMPfam hit to PF06263, Bacterial FdrA, score 0 550538002630 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 550538002631 HMMPfam hit to PF06545, Protein of unknown function DUF1116, score 0 550538002632 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 550538002633 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 550538002634 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 550538002635 putative substrate binding site [chemical binding]; other site 550538002636 nucleotide binding site [chemical binding]; other site 550538002637 nucleotide binding site [chemical binding]; other site 550538002638 homodimer interface [polypeptide binding]; other site 550538002639 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 5.9e-77 550538002640 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 550538002641 ATP-grasp domain; Region: ATP-grasp; pfam02222 550538002642 HMMPfam hit to PF02222, ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type, score 1.4e-91 550538002643 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 550538002644 HMMPfam hit to PF00731, 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase, score 1.4e-105 550538002645 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 550538002646 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 550538002647 putative active site [active] 550538002648 putative metal binding site [ion binding]; other site 550538002649 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.5e-13 550538002650 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 550538002651 substrate binding site [chemical binding]; other site 550538002652 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 4.5e-53 550538002653 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 550538002654 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 550538002655 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 550538002656 active site 550538002657 HIGH motif; other site 550538002658 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 550538002659 KMSKS motif; other site 550538002660 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 550538002661 tRNA binding surface [nucleotide binding]; other site 550538002662 anticodon binding site; other site 550538002663 HMMPfam hit to PF01406, Cysteinyl-tRNA synthetase, class Ia, N-terminal, score 8.8e-222 550538002664 HMMPfam hit to PF09190, Cysteinyl-tRNA synthetase, class Ia, DALR, score 5.6e-34 550538002665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 550538002666 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 550538002667 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 550538002668 4 probable transmembrane helices predicted for SG0552 by TMHMM2.0 at aa 12-34, 54-76, 89-108 and 149-171 550538002669 HMMPfam hit to PF04307, Protein of unknown function DUF457, transmembrane, score 2.2e-34 550538002670 ribosome-associated protein; Provisional; Region: PRK11507 550538002671 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 550538002672 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 550538002673 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 550538002674 homodimer interface [polypeptide binding]; other site 550538002675 NADP binding site [chemical binding]; other site 550538002676 substrate binding site [chemical binding]; other site 550538002677 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 4.5e-108 550538002678 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 550538002679 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 9.6e-72 550538002680 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 550538002681 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002682 fimbrial operon Fim 550538002683 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 550538002684 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.5e-49 550538002685 fimbrial protein FimI; Provisional; Region: PRK15200 550538002686 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 4.1e-29 550538002687 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 550538002688 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538002689 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538002690 1 probable transmembrane helix predicted for SG0557 by TMHMM2.0 at aa 7-29 550538002691 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 5.4e-69 550538002692 PS00635 Gram-negative pili assembly chaperone signature. 550538002693 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 6.2e-30 550538002694 outer membrane usher protein FimD; Provisional; Region: PRK15198 550538002695 PapC N-terminal domain; Region: PapC_N; pfam13954 550538002696 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 550538002697 PapC C-terminal domain; Region: PapC_C; pfam13953 550538002698 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538002699 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 550538002700 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 550538002701 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 550538002702 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 5.8e-56 550538002703 fimbrial operon FimZ,Y,X 550538002704 transcriptional regulator FimZ; Provisional; Region: PRK09935 550538002705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538002706 active site 550538002707 phosphorylation site [posttranslational modification] 550538002708 intermolecular recognition site; other site 550538002709 dimerization interface [polypeptide binding]; other site 550538002710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538002711 DNA binding residues [nucleotide binding] 550538002712 dimerization interface [polypeptide binding]; other site 550538002713 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 7.5e-30 550538002714 PS00622 Bacterial regulatory proteins, luxR family signature. 550538002715 HMMPfam hit to PF00072, Response regulator receiver, score 2.5e-38 550538002716 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 550538002717 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 550538002718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538002719 DNA binding residues [nucleotide binding] 550538002720 dimerization interface [polypeptide binding]; other site 550538002721 Salmonella Pathogenicity Island 16; SPI-16 550538002722 the sequence has been checked and is believed to be correct 550538002723 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.1e-19 550538002724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 550538002725 Transposase; Region: HTH_Tnp_1; pfam01527 550538002726 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.3e-10 550538002727 9 probable transmembrane helices predicted for SG0567 by TMHMM2.0 at aa 13-32, 77-96, 108-130, 135-157, 201-223, 254-273, 280-302, 307-329 and 336-358 550538002728 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 550538002729 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 550538002730 Ligand binding site; other site 550538002731 Putative Catalytic site; other site 550538002732 DXD motif; other site 550538002733 2 probable transmembrane helices predicted for SG0568 by TMHMM2.0 at aa 227-249 and 264-286 550538002734 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.3e-33 550538002735 Predicted membrane protein [Function unknown]; Region: COG2246 550538002736 GtrA-like protein; Region: GtrA; pfam04138 550538002737 HMMPfam hit to PF04138, GtrA-like protein, score 3e-31 550538002738 4 probable transmembrane helices predicted for SG0569 by TMHMM2.0 at aa 12-31, 35-54, 67-84 and 94-116 550538002740 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.7e-34 550538002743 Cupin; Region: Cupin_6; pfam12852 550538002744 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 550538002745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538002746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538002747 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.4e-08 550538002748 PS00041 Bacterial regulatory proteins, araC family signature. 550538002749 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.7e-05 550538002750 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 550538002751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538002752 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 550538002753 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 7.6e-52 550538002754 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002755 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 550538002756 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.9e-31 550538002757 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 9.8e-37 550538002758 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538002759 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.1e-05 550538002760 Predicted membrane protein [Function unknown]; Region: COG3059 550538002761 HMMPfam hit to PF04224, Protein of unknown function DUF417, score 3.3e-108 550538002762 4 probable transmembrane helices predicted for SG0576 by TMHMM2.0 at aa 13-32, 87-106, 113-135 and 164-183 550538002763 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 550538002764 phenylalanine transporter; Provisional; Region: PRK10249 550538002765 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.4e-148 550538002766 12 probable transmembrane helices predicted for SG0578 by TMHMM2.0 at aa 34-53, 57-74, 107-129, 139-161, 166-188, 210-232, 253-275, 295-317, 344-366, 370-392, 413-435 and 440-459 550538002767 PS00218 Amino acid permeases signature. 550538002768 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 550538002769 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538002770 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.1e-61 550538002771 5 probable transmembrane helices predicted for SG0579 by TMHMM2.0 at aa 21-43, 72-89, 102-124, 139-161 and 166-183 550538002772 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 550538002773 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 550538002774 active site 550538002775 oxyanion hole [active] 550538002776 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 550538002777 catalytic triad [active] 550538002778 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 550538002779 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 2.3e-10 550538002780 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.2e-34 550538002781 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 550538002782 dimer interface [polypeptide binding]; other site 550538002783 FMN binding site [chemical binding]; other site 550538002784 HMMPfam hit to PF00881, Nitroreductase, score 6.2e-73 550538002785 hypothetical protein; Provisional; Region: PRK10250 550538002786 HMMPfam hit to PF04237, Protein of unknown function DUF419, score 9.3e-45 550538002787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 550538002788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538002789 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2.1e-12 550538002790 PS01081 Bacterial regulatory proteins, tetR family signature. 550538002791 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 550538002792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538002793 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.3e-10 550538002794 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.1e-10 550538002795 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 550538002796 HMMPfam hit to PF06643, Protein of unknown function DUF1158, score 2.5e-56 550538002797 2 probable transmembrane helices predicted for SG0586 by TMHMM2.0 at aa 13-35 and 50-72 550538002798 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 550538002799 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 550538002800 HMMPfam hit to PF04107, Glutamate--cysteine ligase, GCS2, score 2e-114 550538002801 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 550538002802 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 550538002803 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 1.3e-05 550538002804 outer membrane receptor FepA; Provisional; Region: PRK13524 550538002805 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 550538002806 N-terminal plug; other site 550538002807 ligand-binding site [chemical binding]; other site 550538002808 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 2.7e-30 550538002809 PS01156 TonB-dependent receptor proteins signature 2. 550538002810 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 2.4e-29 550538002811 PS00430 TonB-dependent receptor proteins signature 1. 550538002812 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 550538002813 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 550538002814 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 550538002815 HMMPfam hit to PF00756, esterase, score 1.5e-61 550538002816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 550538002817 HMMPfam hit to PF03621, MbtH-like protein, score 5.2e-30 550538002818 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 550538002819 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 550538002820 acyl-activating enzyme (AAE) consensus motif; other site 550538002821 AMP binding site [chemical binding]; other site 550538002822 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 550538002823 HMMPfam hit to PF00668, Condensation domain, score 9.4e-60 550538002824 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 6.9e-159 550538002825 PS00455 AMP-binding domain signature. 550538002826 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 1e-09 550538002827 PS00012 Phosphopantetheine attachment site. 550538002828 HMMPfam hit to PF00975, Thioesterase, score 3.5e-49 550538002829 LPS O-antigen length regulator; Provisional; Region: PRK10381 550538002830 Chain length determinant protein; Region: Wzz; pfam02706 550538002831 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 3.2e-22 550538002832 2 probable transmembrane helices predicted for SG0593 by TMHMM2.0 at aa 43-62 and 338-360 550538002833 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 550538002834 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 550538002835 Walker A/P-loop; other site 550538002836 ATP binding site [chemical binding]; other site 550538002837 Q-loop/lid; other site 550538002838 ABC transporter signature motif; other site 550538002839 Walker B; other site 550538002840 D-loop; other site 550538002841 H-loop/switch region; other site 550538002842 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-50 550538002843 PS00211 ABC transporters family signature. 550538002844 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002845 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 550538002846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538002847 ABC-ATPase subunit interface; other site 550538002848 dimer interface [polypeptide binding]; other site 550538002849 putative PBP binding regions; other site 550538002850 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 7.8e-130 550538002851 8 probable transmembrane helices predicted for SG0595 by TMHMM2.0 at aa 7-26, 57-79, 92-111, 115-137, 144-166, 193-210, 239-261 and 301-323 550538002852 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538002853 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 550538002854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538002855 ABC-ATPase subunit interface; other site 550538002856 dimer interface [polypeptide binding]; other site 550538002857 putative PBP binding regions; other site 550538002858 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 1.5e-138 550538002859 9 probable transmembrane helices predicted for SG0596 by TMHMM2.0 at aa 10-32, 65-82, 92-114, 121-140, 155-177, 198-220, 240-262, 282-304 and 308-326 550538002860 enterobactin exporter EntS; Provisional; Region: PRK10489 550538002861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538002862 putative substrate translocation pore; other site 550538002863 12 probable transmembrane helices predicted for SG0597 by TMHMM2.0 at aa 22-44, 54-76, 83-105, 110-132, 153-175, 179-201, 214-236, 256-278, 285-307, 312-331, 351-373 and 377-399 550538002864 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.6e-25 550538002865 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 550538002866 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 550538002867 siderophore binding site; other site 550538002868 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.3e-51 550538002869 isochorismate synthase EntC; Provisional; Region: PRK15016 550538002870 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 550538002871 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 8.1e-108 550538002872 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 550538002873 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 550538002874 acyl-activating enzyme (AAE) consensus motif; other site 550538002875 active site 550538002876 AMP binding site [chemical binding]; other site 550538002877 substrate binding site [chemical binding]; other site 550538002878 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 1e-102 550538002879 PS00455 AMP-binding domain signature. 550538002880 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 550538002881 hydrophobic substrate binding pocket; other site 550538002882 Isochorismatase family; Region: Isochorismatase; pfam00857 550538002883 active site 550538002884 conserved cis-peptide bond; other site 550538002885 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 550538002886 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 7.6e-102 550538002887 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 2.3e-11 550538002888 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 550538002889 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 550538002890 putative NAD(P) binding site [chemical binding]; other site 550538002891 active site 550538002892 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.7e-26 550538002893 PS00061 Short-chain dehydrogenases/reductases family signature. 550538002894 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 550538002895 CoenzymeA binding site [chemical binding]; other site 550538002896 subunit interaction site [polypeptide binding]; other site 550538002897 PHB binding site; other site 550538002898 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.4e-19 550538002899 carbon starvation protein A; Provisional; Region: PRK15015 550538002900 Carbon starvation protein CstA; Region: CstA; pfam02554 550538002901 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 550538002902 18 probable transmembrane helices predicted for SG0604 by TMHMM2.0 at aa 7-26, 32-54, 89-111, 116-138, 159-181, 191-213, 218-240, 255-277, 284-306, 326-348, 361-383, 398-420, 441-463, 468-487, 514-533, 548-570, 577-599 and 649-671 550538002903 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 2.2e-294 550538002904 Uncharacterized small protein [Function unknown]; Region: COG2879 550538002905 HMMPfam hit to PF04328, Protein of unknown function DUF466, score 6.6e-45 550538002906 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 550538002907 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 550538002908 putative active site [active] 550538002909 metal binding site [ion binding]; metal-binding site 550538002910 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 3.5e-09 550538002911 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538002912 methionine aminotransferase; Validated; Region: PRK09082 550538002913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538002914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538002915 homodimer interface [polypeptide binding]; other site 550538002916 catalytic residue [active] 550538002917 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.5e-54 550538002918 PS00017 ATP/GTP-binding site motif A (P-loop). 550538002919 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 550538002920 ParB-like nuclease domain; Region: ParBc; pfam02195 550538002921 HMMPfam hit to PF02195, ParB-like nuclease, score 1e-14 550538002922 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 550538002923 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 550538002924 Active Sites [active] 550538002925 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 550538002926 HMMPfam hit to PF01507, Phosphoadenosine phosphosulphate reductase, score 6.4e-07 550538002927 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 550538002928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538002929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538002930 dimerization interface [polypeptide binding]; other site 550538002931 HMMPfam hit to PF03466, LysR, substrate-binding, score 4e-05 550538002932 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.6e-21 550538002933 PS00044 Bacterial regulatory proteins, lysR family signature. 550538002934 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 550538002935 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 550538002936 dimerization domain [polypeptide binding]; other site 550538002937 dimer interface [polypeptide binding]; other site 550538002938 catalytic residues [active] 550538002939 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 550538002940 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 550538002941 dimer interface [polypeptide binding]; other site 550538002942 decamer (pentamer of dimers) interface [polypeptide binding]; other site 550538002943 catalytic triad [active] 550538002944 peroxidatic and resolving cysteines [active] 550538002945 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 7.5e-40 550538002946 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 550538002947 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 550538002948 catalytic residue [active] 550538002949 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 550538002950 catalytic residues [active] 550538002951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538002952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538002953 HMMPfam hit to PF00462, Glutaredoxin, score 0.00094 550538002954 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.9e-45 550538002955 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 550538002956 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 4.9e-23 550538002957 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 550538002958 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 7.9e-56 550538002959 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 550538002960 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 550538002961 putative [4Fe-4S] binding site [ion binding]; other site 550538002962 putative molybdopterin cofactor binding site [chemical binding]; other site 550538002963 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 550538002964 molybdopterin cofactor binding site; other site 550538002965 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 4.9e-09 550538002966 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 7.4e-54 550538002967 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 7.1e-21 550538002968 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 550538002969 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 550538002970 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0019 550538002971 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.4e-07 550538002972 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538002973 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 550538002974 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 6.3e-12 550538002975 8 probable transmembrane helices predicted for SG0617 by TMHMM2.0 at aa 5-27, 39-61, 76-95, 102-124, 134-156, 163-185, 195-217 and 224-241 550538002976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 550538002977 Ligand Binding Site [chemical binding]; other site 550538002978 HMMPfam hit to PF00582, UspA, score 5.9e-16 550538002979 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 550538002980 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 550538002981 NAD binding site [chemical binding]; other site 550538002982 catalytic Zn binding site [ion binding]; other site 550538002983 structural Zn binding site [ion binding]; other site 550538002984 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.8e-48 550538002985 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538002986 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 2.6e-22 550538002987 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 550538002988 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 550538002989 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 0.0035 550538002990 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 550538002991 B1 nucleotide binding pocket [chemical binding]; other site 550538002992 B2 nucleotide binding pocket [chemical binding]; other site 550538002993 CAS motifs; other site 550538002994 active site 550538002995 PS00531 Ribonuclease T2 family histidine active site 2. 550538002996 PS00530 Ribonuclease T2 family histidine active site 1. 550538002997 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 550538002998 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 550538002999 transmembrane helices; other site 550538003000 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 9.7e-288 550538003001 13 probable transmembrane helices predicted for SG0622 by TMHMM2.0 at aa 7-24, 34-53, 58-75, 95-117, 138-157, 198-220, 233-255, 288-305, 307-329, 339-361, 374-396, 428-450 and 463-485 550538003002 the sequence has been checked and is believed to be correct 550538003003 HMMPfam hit to PF01874, Triphosphoribosyl-dephospho-CoA protein, score 5e-125 550538003004 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 550538003005 HMMPfam hit to PF03802, Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, score 2.7e-84 550538003006 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003007 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 550538003008 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 550538003009 HMMPfam hit to PF04223, Citrate lyase, alpha subunit, score 0 550538003010 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538003011 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 550538003012 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 1.8e-117 550538003013 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 550538003014 HMMPfam hit to PF04953, Citrate lyase acyl carrier protein CitD, score 3.6e-62 550538003015 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 550538003016 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 550538003017 putative active site [active] 550538003018 (T/H)XGH motif; other site 550538003019 HMMPfam hit to PF08218, Citrate lyase ligase, C-terminal, score 3.5e-123 550538003020 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 6.1e-05 550538003021 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 550538003022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538003023 putative active site [active] 550538003024 heme pocket [chemical binding]; other site 550538003025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538003026 ATP binding site [chemical binding]; other site 550538003027 Mg2+ binding site [ion binding]; other site 550538003028 G-X-G motif; other site 550538003029 2 probable transmembrane helices predicted for SG0629 by TMHMM2.0 at aa 20-42 and 180-202 550538003030 HMMPfam hit to PF00989, PAS fold, score 9.3e-06 550538003031 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 8.3e-27 550538003032 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 550538003033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538003034 active site 550538003035 phosphorylation site [posttranslational modification] 550538003036 intermolecular recognition site; other site 550538003037 dimerization interface [polypeptide binding]; other site 550538003038 Transcriptional regulator; Region: CitT; pfam12431 550538003039 HMMPfam hit to PF00072, Response regulator receiver, score 7.7e-24 550538003040 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 550538003041 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 550538003042 10 probable transmembrane helices predicted for SG0631 by TMHMM2.0 at aa 37-59, 80-102, 117-139, 152-174, 194-216, 223-245, 265-287, 299-321, 363-385 and 392-414 550538003043 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.3e-173 550538003044 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 550538003045 1 probable transmembrane helix predicted for SG0632 by TMHMM2.0 at aa 7-29 550538003046 HMMPfam hit to PF07017, Antimicrobial peptide resistance and lipid A acylation PagP, score 4.1e-118 550538003047 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 550538003048 DNA-binding site [nucleotide binding]; DNA binding site 550538003049 RNA-binding motif; other site 550538003050 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 2e-44 550538003051 PS00352 'Cold-shock' DNA-binding domain signature. 550538003052 chromosome condensation membrane protein; Provisional; Region: PRK14196 550538003053 4 probable transmembrane helices predicted for SG0634 by TMHMM2.0 at aa 5-22, 32-54, 67-89 and 99-121 550538003054 HMMPfam hit to PF02537, Camphor resistance CrcB protein, score 1.6e-58 550538003055 Predicted amidohydrolase [General function prediction only]; Region: COG0388 550538003056 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 550538003057 putative active site [active] 550538003058 catalytic triad [active] 550538003059 putative dimer interface [polypeptide binding]; other site 550538003060 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 4.9e-23 550538003061 PS01227 Uncharacterized protein family UPF0012 signature. 550538003062 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 550538003063 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 1.7e-08 550538003064 1 probable transmembrane helix predicted for SG0636 by TMHMM2.0 at aa 4-21 550538003065 lipoyl synthase; Provisional; Region: PRK05481 550538003066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538003067 FeS/SAM binding site; other site 550538003068 HMMPfam hit to PF04055, Radical SAM, score 4.6e-23 550538003069 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 550538003070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538003071 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 550538003072 substrate binding pocket [chemical binding]; other site 550538003073 dimerization interface [polypeptide binding]; other site 550538003074 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.2e-09 550538003075 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 7.8e-16 550538003076 PS00044 Bacterial regulatory proteins, lysR family signature. 550538003077 lipoate-protein ligase B; Provisional; Region: PRK14342 550538003078 PS00092 N-6 Adenine-specific DNA methylases signature. 550538003079 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 8.1e-18 550538003080 PS01313 Lipoate-protein ligase B signature. 550538003081 hypothetical protein; Provisional; Region: PRK04998 550538003082 HMMPfam hit to PF04359, Protein of unknown function DUF493, score 3.6e-54 550538003083 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 550538003084 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 550538003085 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 550538003086 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 2.4e-37 550538003087 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 7.8e-153 550538003088 rare lipoprotein A; Provisional; Region: PRK10672 550538003089 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 550538003090 Sporulation related domain; Region: SPOR; pfam05036 550538003091 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 3.8e-19 550538003092 HMMPfam hit to PF03330, Rare lipoprotein A, score 4e-27 550538003093 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003094 cell wall shape-determining protein; Provisional; Region: PRK10794 550538003095 HMMPfam hit to PF01098, Cell cycle protein, score 1.8e-183 550538003096 9 probable transmembrane helices predicted for SG0643 by TMHMM2.0 at aa 15-37, 50-67, 77-99, 136-155, 160-179, 181-203, 272-294, 306-328 and 338-360 550538003097 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 550538003098 penicillin-binding protein 2; Provisional; Region: PRK10795 550538003099 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 550538003100 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 550538003101 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 2.5e-103 550538003102 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 4.2e-68 550538003103 1 probable transmembrane helix predicted for SG0644 by TMHMM2.0 at aa 21-43 550538003104 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 550538003105 HMMPfam hit to PF02590, Protein of unknown function DUF163, score 7.3e-113 550538003106 ribosome-associated protein; Provisional; Region: PRK11538 550538003107 HMMPfam hit to PF02410, Iojap-related protein, score 1.3e-53 550538003108 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003109 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 550538003110 catalytic core [active] 550538003111 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 3.6e-48 550538003112 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 550538003113 the sequence has been checked and is believed to be correct 550538003114 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.9e-35 550538003115 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 550538003116 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 550538003117 active site 550538003118 (T/H)XGH motif; other site 550538003119 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.4e-61 550538003120 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 550538003121 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 550538003122 HMMPfam hit to PF06144, DNA polymerase III, delta, score 1.3e-129 550538003123 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 550538003124 HMMPfam hit to PF04390, Rare lipoprotein B, score 1e-78 550538003125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003126 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 550538003127 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 550538003128 HIGH motif; other site 550538003129 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 550538003130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 550538003131 active site 550538003132 KMSKS motif; other site 550538003133 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 550538003134 tRNA binding surface [nucleotide binding]; other site 550538003135 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 2.1e-07 550538003136 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 2e-13 550538003137 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538003138 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 550538003139 HMMPfam hit to PF08666, SAF domain, score 6.8e-08 550538003140 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 550538003141 HMMPfam hit to PF04295, D-galactarate dehydratase/Altronate hydrolase, C-terminal, score 1.2e-153 550538003142 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 550538003143 HMMPfam hit to PF03812, 2-keto-3-deoxygluconate permease, score 2e-80 550538003144 8 probable transmembrane helices predicted for SG0655 by TMHMM2.0 at aa 7-25, 35-57, 70-92, 157-179, 192-211, 216-238, 247-269 and 279-301 550538003145 the sequence has been checked and is believed to be correct 550538003146 HMMPfam hit to PF06506, Propionate catabolism activator, N-terminal, score 9.7e-08 550538003147 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.3e-129 550538003148 hypothetical protein; Provisional; Region: PRK11032 550538003149 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 550538003150 HMMPfam hit to PF07295, Protein of unknown function DUF1451, score 3.4e-101 550538003151 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538003152 Sel1-like repeats; Region: SEL1; smart00671 550538003153 Sel1-like repeats; Region: SEL1; smart00671 550538003154 Sel1-like repeats; Region: SEL1; smart00671 550538003155 Sel1-like repeats; Region: SEL1; smart00671 550538003156 Sel1-like repeats; Region: SEL1; smart00671 550538003157 HMMPfam hit to PF08238, Sel1-like, score 0.00013 550538003158 HMMPfam hit to PF08238, Sel1-like, score 2.2e-06 550538003159 HMMPfam hit to PF08238, Sel1-like, score 2.4e-13 550538003160 HMMPfam hit to PF08238, Sel1-like, score 1.2e-06 550538003161 HMMPfam hit to PF08238, Sel1-like, score 2.2e-12 550538003162 HMMPfam hit to PF08238, Sel1-like, score 6.3e-05 550538003163 HMMPfam hit to PF08238, Sel1-like, score 0.00034 550538003164 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 550538003165 HMMPfam hit to PF06889, Protein of unknown function DUF1266, score 5.6e-199 550538003166 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 550538003167 HSP70 interaction site [polypeptide binding]; other site 550538003168 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 5e-07 550538003169 1 probable transmembrane helix predicted for SG0660 by TMHMM2.0 at aa 453-472 550538003170 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 550538003171 HMMPfam hit to PF06889, Protein of unknown function DUF1266, score 2.5e-194 550538003172 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 550538003173 HSP70 interaction site [polypeptide binding]; other site 550538003174 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 0.0017 550538003175 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 550538003176 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 550538003177 nucleotide binding site [chemical binding]; other site 550538003178 putative NEF/HSP70 interaction site [polypeptide binding]; other site 550538003179 SBD interface [polypeptide binding]; other site 550538003180 HMMPfam hit to PF00012, Heat shock protein 70, score 2.5e-97 550538003181 PS01036 Heat shock hsp70 proteins family signature 3. 550538003182 PS00329 Heat shock hsp70 proteins family signature 2. 550538003183 PS00297 Heat shock hsp70 proteins family signature 1. 550538003184 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 550538003185 active site 550538003186 tetramer interface [polypeptide binding]; other site 550538003187 HMMPfam hit to PF01156, Inosine/uridine-preferring nucleoside hydrolase, score 1.1e-180 550538003188 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 550538003189 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 550538003190 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 550538003191 Walker A/P-loop; other site 550538003192 ATP binding site [chemical binding]; other site 550538003193 Q-loop/lid; other site 550538003194 ABC transporter signature motif; other site 550538003195 Walker B; other site 550538003196 D-loop; other site 550538003197 H-loop/switch region; other site 550538003198 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-65 550538003199 PS00211 ABC transporters family signature. 550538003200 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003201 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538003202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538003203 dimer interface [polypeptide binding]; other site 550538003204 conserved gate region; other site 550538003205 putative PBP binding loops; other site 550538003206 ABC-ATPase subunit interface; other site 550538003207 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.4e-30 550538003208 5 probable transmembrane helices predicted for SG0667 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 550538003209 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538003211 dimer interface [polypeptide binding]; other site 550538003212 conserved gate region; other site 550538003213 putative PBP binding loops; other site 550538003214 ABC-ATPase subunit interface; other site 550538003215 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8.2e-38 550538003216 5 probable transmembrane helices predicted for SG0668 by TMHMM2.0 at aa 31-53, 66-88, 108-127, 179-196 and 211-233 550538003217 the sequence has been checked and is believed to be correct 550538003218 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 2.1e-53 550538003219 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 550538003220 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 550538003221 putative active site [active] 550538003222 catalytic triad [active] 550538003223 putative dimer interface [polypeptide binding]; other site 550538003224 8 probable transmembrane helices predicted for SG0670 by TMHMM2.0 at aa 12-29, 33-50, 57-79, 89-111, 124-146, 166-188, 195-213 and 489-507 550538003225 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 1.7e-51 550538003226 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 550538003227 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 550538003228 Transporter associated domain; Region: CorC_HlyC; smart01091 550538003229 HMMPfam hit to PF03471, Transporter-associated region, score 1.7e-29 550538003230 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 6.4e-28 550538003231 metal-binding heat shock protein; Provisional; Region: PRK00016 550538003232 HMMPfam hit to PF02130, Protein of unknown function UPF0054, score 2.9e-53 550538003233 PS01306 Uncharacterized protein family UPF0054 signature. 550538003234 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 550538003235 PhoH-like protein; Region: PhoH; pfam02562 550538003236 HMMPfam hit to PF02562, PhoH-like protein, score 6.3e-154 550538003237 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003238 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 550538003239 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 550538003240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538003241 FeS/SAM binding site; other site 550538003242 TRAM domain; Region: TRAM; pfam01938 550538003243 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 2.1e-26 550538003244 HMMPfam hit to PF04055, Radical SAM, score 8.4e-34 550538003245 PS01278 Uncharacterized protein family UPF0004 signature. 550538003246 HMMPfam hit to PF00919, Protein of unknown function UPF0004, N-terminal, score 5.3e-51 550538003247 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 550538003248 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 550538003249 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 8.6e-07 550538003250 1 probable transmembrane helix predicted for SG0675 by TMHMM2.0 at aa 7-29 550538003251 PS01304 ubiH/COQ6 monooxygenase family signature. 550538003252 4 probable transmembrane helices predicted for SG0676 by TMHMM2.0 at aa 7-28, 33-55, 99-121 and 131-153 550538003253 asparagine synthetase B; Provisional; Region: asnB; PRK09431 550538003254 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 550538003255 active site 550538003256 dimer interface [polypeptide binding]; other site 550538003257 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 550538003258 Ligand Binding Site [chemical binding]; other site 550538003259 Molecular Tunnel; other site 550538003260 HMMPfam hit to PF00733, Asparagine synthase, score 2.5e-109 550538003261 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1.2e-24 550538003262 PS00443 Glutamine amidotransferases class-II active site. 550538003263 UMP phosphatase; Provisional; Region: PRK10444 550538003264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538003265 active site 550538003266 motif I; other site 550538003267 motif II; other site 550538003268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538003269 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.5e-17 550538003270 MarR family; Region: MarR; pfam01047 550538003271 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 550538003272 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538003273 nucleotide binding site [chemical binding]; other site 550538003274 HMMPfam hit to PF00480, ROK, score 2.4e-84 550538003275 PS01125 ROK family signature. 550538003276 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 2.5e-07 550538003277 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 550538003278 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 550538003279 active site 550538003280 dimer interface [polypeptide binding]; other site 550538003281 HMMPfam hit to PF01979, Amidohydrolase 1, score 4.9e-56 550538003282 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 550538003283 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 550538003284 active site 550538003285 trimer interface [polypeptide binding]; other site 550538003286 allosteric site; other site 550538003287 active site lid [active] 550538003288 hexamer (dimer of trimers) interface [polypeptide binding]; other site 550538003289 HMMPfam hit to PF01182, Glucosamine/galactosamine-6-phosphate isomerase, score 3.3e-194 550538003290 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 550538003291 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 550538003292 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 550538003293 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 550538003294 active site turn [active] 550538003295 phosphorylation site [posttranslational modification] 550538003296 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 550538003297 HPr interaction site; other site 550538003298 glycerol kinase (GK) interaction site [polypeptide binding]; other site 550538003299 active site 550538003300 phosphorylation site [posttranslational modification] 550538003301 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 9.3e-101 550538003302 11 probable transmembrane helices predicted for SG0682 by TMHMM2.0 at aa 13-30, 40-62, 69-91, 96-118, 131-153, 163-185, 192-214, 229-251, 258-280, 295-317 and 337-359 550538003303 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 6.2e-17 550538003304 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 550538003305 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 1.3e-82 550538003306 PS00371 PTS EIIA domains phosphorylation site signature 1. 550538003307 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 550538003308 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 550538003309 active site 550538003310 HIGH motif; other site 550538003311 nucleotide binding site [chemical binding]; other site 550538003312 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 550538003313 KMSKS motif; other site 550538003314 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 550538003315 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 8.2e-187 550538003316 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538003317 HMMPfam hit to PF03950, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 3.6e-108 550538003318 outer membrane porin, OprD family; Region: OprD; pfam03573 550538003319 HMMPfam hit to PF03573, Outer membrane porin, bacterial, score 2.1e-06 550538003320 1 probable transmembrane helix predicted for SG0684 by TMHMM2.0 at aa 9-28 550538003321 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 550538003322 YbfN-like lipoprotein; Region: YbfN; pfam13982 550538003323 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003324 citrate-proton symporter; Provisional; Region: PRK15075 550538003325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538003326 putative substrate translocation pore; other site 550538003327 12 probable transmembrane helices predicted for SG0686 by TMHMM2.0 at aa 20-42, 57-79, 88-110, 120-142, 163-185, 189-211, 239-261, 276-298, 305-327, 337-356, 369-391 and 401-423 550538003328 HMMPfam hit to PF00083, General substrate transporter, score 2.5e-81 550538003329 PS00216 Sugar transport proteins signature 1. 550538003330 PS00217 Sugar transport proteins signature 2. 550538003331 PS00216 Sugar transport proteins signature 1. 550538003332 tricarballylate utilization protein B; Provisional; Region: PRK15033 550538003333 6 probable transmembrane helices predicted for SG0687 by TMHMM2.0 at aa 112-134, 154-176, 230-252, 262-284, 305-322 and 327-349 550538003334 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0023 550538003335 tricarballylate dehydrogenase; Validated; Region: PRK08274 550538003336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538003337 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.8e-09 550538003338 HMMPfam hit to PF03486, HI0933-like protein, score 4.1e-06 550538003339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538003340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538003341 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 550538003342 putative dimerization interface [polypeptide binding]; other site 550538003343 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.4e-34 550538003344 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.8e-17 550538003345 ferric uptake regulator; Provisional; Region: fur; PRK09462 550538003346 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 550538003347 metal binding site 2 [ion binding]; metal-binding site 550538003348 putative DNA binding helix; other site 550538003349 metal binding site 1 [ion binding]; metal-binding site 550538003350 dimer interface [polypeptide binding]; other site 550538003351 structural Zn2+ binding site [ion binding]; other site 550538003352 HMMPfam hit to PF01475, Ferric-uptake regulator, score 3.2e-74 550538003353 flavodoxin FldA; Validated; Region: PRK09267 550538003354 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 8.9e-55 550538003355 PS00201 Flavodoxin signature. 550538003356 LexA regulated protein; Provisional; Region: PRK11675 550538003357 HMMPfam hit to PF01402, CopG-like DNA-binding, score 6.4e-07 550538003358 acyl-CoA esterase; Provisional; Region: PRK10673 550538003359 PGAP1-like protein; Region: PGAP1; pfam07819 550538003360 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 5e-17 550538003361 SeqA protein; Region: SeqA; cl11470 550538003362 HMMPfam hit to PF03925, SeqA protein, score 1.3e-87 550538003363 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 550538003364 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 550538003365 active site 550538003366 substrate binding site [chemical binding]; other site 550538003367 metal binding site [ion binding]; metal-binding site 550538003368 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 5e-43 550538003369 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 550538003370 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 2e-19 550538003371 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 8.4e-29 550538003372 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 9e-15 550538003373 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 550538003374 putrescine transporter; Provisional; Region: potE; PRK10655 550538003375 12 probable transmembrane helices predicted for SG0697 by TMHMM2.0 at aa 9-31, 37-59, 88-110, 115-137, 150-172, 187-206, 227-249, 269-291, 325-342, 352-374, 387-405 and 410-429 550538003376 HMMPfam hit to PF00324, Amino acid permease-associated region, score 9.8e-10 550538003377 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003378 ornithine decarboxylase; Provisional; Region: PRK13578 550538003379 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 550538003380 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 550538003381 homodimer interface [polypeptide binding]; other site 550538003382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538003383 catalytic residue [active] 550538003384 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 550538003385 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 3.4e-87 550538003386 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 0 550538003387 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 550538003388 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 1.6e-46 550538003389 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 550538003390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538003391 active site 550538003392 phosphorylation site [posttranslational modification] 550538003393 intermolecular recognition site; other site 550538003394 dimerization interface [polypeptide binding]; other site 550538003395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538003396 DNA binding site [nucleotide binding] 550538003397 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.7e-18 550538003398 HMMPfam hit to PF00072, Response regulator receiver, score 4.1e-46 550538003399 sensor protein KdpD; Provisional; Region: PRK10490 550538003400 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 550538003401 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 550538003402 Ligand Binding Site [chemical binding]; other site 550538003403 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 550538003404 GAF domain; Region: GAF_3; pfam13492 550538003405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538003406 dimer interface [polypeptide binding]; other site 550538003407 phosphorylation site [posttranslational modification] 550538003408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538003409 ATP binding site [chemical binding]; other site 550538003410 Mg2+ binding site [ion binding]; other site 550538003411 G-X-G motif; other site 550538003412 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2e-33 550538003413 4 probable transmembrane helices predicted for SG0700 by TMHMM2.0 at aa 399-421, 428-450, 476-498 and 840-862 550538003414 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 9.1e-16 550538003415 HMMPfam hit to PF00582, UspA, score 1.2e-09 550538003416 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor, N-terminal, score 5e-155 550538003417 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003418 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 550538003419 HMMPfam hit to PF02669, K+ transporting ATPase, KdpC subunit, score 1.3e-112 550538003420 1 probable transmembrane helix predicted for SG0701 by TMHMM2.0 at aa 12-34 550538003421 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 550538003422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 550538003423 7 probable transmembrane helices predicted for SG0702 by TMHMM2.0 at aa 33-55, 59-81, 220-242, 252-274, 578-600, 615-634 and 654-676 550538003424 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.4e-35 550538003425 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538003426 PS00154 E1-E2 ATPases phosphorylation site. 550538003427 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 3.6e-66 550538003428 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 550538003429 HMMPfam hit to PF03814, K+ transporting ATPase, A subunit, score 0 550538003430 12 probable transmembrane helices predicted for SG0703 by TMHMM2.0 at aa 5-27, 62-84, 130-152, 173-195, 253-275, 282-301, 325-347, 354-376, 380-399, 419-438, 483-505 and 526-548 550538003431 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 550538003432 1 probable transmembrane helix predicted for SG0704 by TMHMM2.0 at aa 11-33 550538003433 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 550538003434 DNA photolyase; Region: DNA_photolyase; pfam00875 550538003435 HMMPfam hit to PF00875, DNA photolyase, N-terminal, score 1.1e-80 550538003436 HMMPfam hit to PF03441, DNA photolyase, FAD-binding, score 3.1e-158 550538003437 PS00394 DNA photolyases class 1 signature 1. 550538003438 PS00691 DNA photolyases class 1 signature 2. 550538003439 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 550538003440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538003441 putative substrate translocation pore; other site 550538003442 POT family; Region: PTR2; pfam00854 550538003443 14 probable transmembrane helices predicted for SG0706 by TMHMM2.0 at aa 13-35, 50-67, 72-94, 98-117, 138-157, 167-189, 209-231, 235-254, 267-284, 310-332, 344-366, 376-394, 407-429 and 462-479 550538003444 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 5.4e-100 550538003445 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 550538003446 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 550538003447 Uncharacterized conserved protein [Function unknown]; Region: COG0327 550538003448 metal-binding protein; Provisional; Region: PRK10799 550538003449 HMMPfam hit to PF01784, NGG1p interacting factor 3, NIF3, score 2.5e-117 550538003450 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 550538003451 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 550538003452 HMMPfam hit to PF02682, Allophanate hydrolase subunit 1, score 3.8e-133 550538003453 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 550538003454 HMMPfam hit to PF02626, Allophanate hydrolase subunit 2, score 3.3e-171 550538003455 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 550538003456 putative active site [active] 550538003457 HMMPfam hit to PF03746, LamB/YcsF, score 2.7e-143 550538003458 endonuclease VIII; Provisional; Region: PRK10445 550538003459 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 550538003460 DNA binding site [nucleotide binding] 550538003461 catalytic residue [active] 550538003462 putative catalytic residues [active] 550538003463 H2TH interface [polypeptide binding]; other site 550538003464 intercalation triad [nucleotide binding]; other site 550538003465 substrate specificity determining residue; other site 550538003466 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 550538003467 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 550538003468 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase, catalytic, score 4.4e-16 550538003469 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, H2TH DNA binding, score 4.2e-33 550538003470 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 0.0015 550538003471 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 550538003472 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 550538003473 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 550538003474 HMMPfam hit to PF05145, ammonia monooxygenase, score 3.1e-130 550538003475 6 probable transmembrane helices predicted for SG0712 by TMHMM2.0 at aa 21-43, 53-75, 116-135, 145-167, 234-256 and 289-311 550538003476 PS00099 Thiolases active site. 550538003477 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003478 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 550538003479 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 550538003480 dimer interface [polypeptide binding]; other site 550538003481 active site 550538003482 citrylCoA binding site [chemical binding]; other site 550538003483 NADH binding [chemical binding]; other site 550538003484 cationic pore residues; other site 550538003485 oxalacetate/citrate binding site [chemical binding]; other site 550538003486 coenzyme A binding site [chemical binding]; other site 550538003487 catalytic triad [active] 550538003488 HMMPfam hit to PF00285, Citrate synthase, score 3.1e-234 550538003489 PS00480 Citrate synthase signature. 550538003490 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 550538003491 Iron-sulfur protein interface; other site 550538003492 proximal quinone binding site [chemical binding]; other site 550538003493 SdhD (CybS) interface [polypeptide binding]; other site 550538003494 proximal heme binding site [chemical binding]; other site 550538003495 HMMPfam hit to PF01127, Succinate dehydrogenase, cytochrome b subunit, score 1.6e-42 550538003496 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 550538003497 3 probable transmembrane helices predicted for SG0715 by TMHMM2.0 at aa 27-49, 69-88 and 109-128 550538003498 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 550538003499 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 550538003500 SdhC subunit interface [polypeptide binding]; other site 550538003501 proximal heme binding site [chemical binding]; other site 550538003502 cardiolipin binding site; other site 550538003503 Iron-sulfur protein interface; other site 550538003504 proximal quinone binding site [chemical binding]; other site 550538003505 3 probable transmembrane helices predicted for SG0716 by TMHMM2.0 at aa 16-38, 48-70 and 91-113 550538003506 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 550538003507 L-aspartate oxidase; Provisional; Region: PRK06175 550538003508 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 550538003509 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 2.6e-172 550538003510 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 550538003511 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 1.7e-68 550538003512 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 550538003513 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 550538003514 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538003515 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 550538003516 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 550538003517 TPP-binding site [chemical binding]; other site 550538003518 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 550538003519 dimer interface [polypeptide binding]; other site 550538003520 PYR/PP interface [polypeptide binding]; other site 550538003521 TPP binding site [chemical binding]; other site 550538003522 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 6.3e-31 550538003523 HMMPfam hit to PF02779, Transketolase, central region, score 8.8e-75 550538003524 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 550538003525 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 550538003526 E3 interaction surface; other site 550538003527 lipoyl attachment site [posttranslational modification]; other site 550538003528 e3 binding domain; Region: E3_binding; pfam02817 550538003529 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 550538003530 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2.6e-21 550538003531 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 550538003532 HMMPfam hit to PF02817, E3 binding, score 1.2e-16 550538003533 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 9.4e-143 550538003534 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 550538003535 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 550538003536 CoA-ligase; Region: Ligase_CoA; pfam00549 550538003537 HMMPfam hit to PF08442, ATP-grasp fold, succinyl-CoA synthetase-type, score 3e-146 550538003538 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003539 HMMPfam hit to PF00549, ATP-citrate lyase/succinyl-CoA ligase, score 2.4e-81 550538003540 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 550538003541 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 550538003542 CoA binding domain; Region: CoA_binding; smart00881 550538003543 CoA-ligase; Region: Ligase_CoA; pfam00549 550538003544 HMMPfam hit to PF02629, CoA-binding, score 9.9e-52 550538003545 HMMPfam hit to PF00549, ATP-citrate lyase/succinyl-CoA ligase, score 2.2e-65 550538003546 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 550538003547 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 550538003548 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 550538003549 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 550538003550 HMMPfam hit to PF01654, Cytochrome bd ubiquinol oxidase, subunit I, score 0 550538003551 9 probable transmembrane helices predicted for SG0723 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 130-152, 184-206, 219-238, 387-409, 421-443 and 472-494 550538003552 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 550538003553 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 550538003554 HMMPfam hit to PF02322, Cytochrome bd ubiquinol oxidase, subunit II, score 6.2e-227 550538003555 8 probable transmembrane helices predicted for SG0724 by TMHMM2.0 at aa 7-24, 77-99, 122-144, 159-181, 202-224, 262-281, 293-315 and 335-357 550538003556 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 550538003557 HMMPfam hit to PF08173, Membrane bound YbgT-like, score 4.9e-14 550538003558 1 probable transmembrane helix predicted for SG0725 by TMHMM2.0 at aa 2-24 550538003559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003560 hypothetical protein; Provisional; Region: PRK10588 550538003561 2 probable transmembrane helices predicted for SG0726 by TMHMM2.0 at aa 24-46 and 51-73 550538003562 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 550538003563 active site 550538003564 HMMPfam hit to PF03061, Thioesterase superfamily, score 6.7e-18 550538003565 colicin uptake protein TolQ; Provisional; Region: PRK10801 550538003566 3 probable transmembrane helices predicted for SG0728 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 550538003567 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 5.9e-64 550538003568 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 550538003569 colicin uptake protein TolR; Provisional; Region: PRK11024 550538003570 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 1.8e-16 550538003571 1 probable transmembrane helix predicted for SG0729 by TMHMM2.0 at aa 17-39 550538003572 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 550538003573 TolA C-terminal; Region: TolA; pfam06519 550538003574 HMMPfam hit to PF06519, Tol-Pal system, TolA, score 1.5e-185 550538003575 1 probable transmembrane helix predicted for SG0730 by TMHMM2.0 at aa 13-35 550538003576 translocation protein TolB; Provisional; Region: tolB; PRK03629 550538003577 TolB amino-terminal domain; Region: TolB_N; pfam04052 550538003578 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 550538003579 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 550538003580 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 550538003581 HMMPfam hit to PF04052, TolB, N-terminal, score 1.2e-86 550538003582 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 0.48 550538003583 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 3.3e-06 550538003584 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 3.4e-07 550538003585 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 7 550538003586 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 0.057 550538003587 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 550538003588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 550538003589 ligand binding site [chemical binding]; other site 550538003590 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003591 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 6.8e-50 550538003592 PS01068 OmpA-like domain. 550538003593 tol-pal system protein YbgF; Provisional; Region: PRK10803 550538003594 Tetratricopeptide repeat; Region: TPR_6; pfam13174 550538003595 Tetratricopeptide repeat; Region: TPR_6; pfam13174 550538003596 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.003 550538003597 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.0039 550538003598 quinolinate synthetase; Provisional; Region: PRK09375 550538003599 HMMPfam hit to PF02445, Quinolinate synthetase A, score 3.2e-185 550538003600 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 550538003601 HMMPfam hit to PF04973, Nicotinamide mononucleotide transporter PnuC, score 8.9e-98 550538003602 6 probable transmembrane helices predicted for SG0735 by TMHMM2.0 at aa 20-42, 49-68, 72-89, 110-127, 158-177 and 184-206 550538003603 zinc transporter ZitB; Provisional; Region: PRK03557 550538003604 HMMPfam hit to PF01545, Cation efflux protein, score 1.8e-113 550538003605 PS00511 Corticotropin-releasing factor family signature. 550538003606 5 probable transmembrane helices predicted for SG0736 by TMHMM2.0 at aa 21-43, 53-71, 84-106, 121-143 and 164-183 550538003607 YbgS-like protein; Region: YbgS; pfam13985 550538003608 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 550538003609 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 550538003610 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 2.8e-185 550538003611 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 550538003612 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 1.8e-39 550538003613 fumarate hydratase; Provisional; Region: PRK06246 550538003614 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 3.9e-168 550538003615 PS00244 Photosynthetic reaction center proteins signature. 550538003616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538003617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538003618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538003619 dimerization interface [polypeptide binding]; other site 550538003620 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-20 550538003621 PS00044 Bacterial regulatory proteins, lysR family signature. 550538003622 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.5e-38 550538003623 cell density-dependent motility repressor; Provisional; Region: PRK10082 550538003624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538003625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538003626 dimerization interface [polypeptide binding]; other site 550538003627 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.4e-05 550538003628 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.7e-17 550538003629 PS00044 Bacterial regulatory proteins, lysR family signature. 550538003630 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 550538003631 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 550538003632 transmembrane helices; other site 550538003633 12 probable transmembrane helices predicted for SG0743 by TMHMM2.0 at aa 2-19, 23-42, 54-76, 91-124, 137-159, 174-196, 221-240, 250-267, 272-294, 304-326, 360-379 and 399-421 550538003634 HMMPfam hit to PF03600, Divalent ion symporter, score 2.8e-07 550538003635 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 550538003636 HMMPfam hit to PF04277, Sodium ion-translocating decarboxylase, score 5e-31 550538003637 1 probable transmembrane helix predicted for SG0744 by TMHMM2.0 at aa 10-32 550538003638 oxaloacetate decarboxylase; Provisional; Region: PRK14040 550538003639 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 550538003640 active site 550538003641 catalytic residues [active] 550538003642 metal binding site [ion binding]; metal-binding site 550538003643 homodimer binding site [polypeptide binding]; other site 550538003644 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 550538003645 carboxyltransferase (CT) interaction site; other site 550538003646 biotinylation site [posttranslational modification]; other site 550538003647 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 3.3e-90 550538003648 HMMPfam hit to PF02436, Conserved carboxylase region, score 3.8e-99 550538003649 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 550538003650 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2e-27 550538003651 PS00188 Biotin-requiring enzymes attachment site. 550538003652 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 550538003653 9 probable transmembrane helices predicted for SG0746 by TMHMM2.0 at aa 13-35, 122-144, 159-178, 180-202, 222-244, 266-288, 308-327, 339-361 and 403-422 550538003654 HMMPfam hit to PF03977, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit, score 1.5e-276 550538003655 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 550538003656 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 550538003657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538003658 dimer interface [polypeptide binding]; other site 550538003659 putative PBP binding regions; other site 550538003660 ABC-ATPase subunit interface; other site 550538003661 9 probable transmembrane helices predicted for SG0748 by TMHMM2.0 at aa 30-49, 81-103, 115-137, 142-161, 174-196, 216-236, 268-290, 305-324 and 331-353 550538003662 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 7.8e-87 550538003663 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 550538003664 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 550538003665 Walker A/P-loop; other site 550538003666 ATP binding site [chemical binding]; other site 550538003667 Q-loop/lid; other site 550538003668 ABC transporter signature motif; other site 550538003669 Walker B; other site 550538003670 D-loop; other site 550538003671 H-loop/switch region; other site 550538003672 HMMPfam hit to PF00005, ABC transporter related, score 5e-48 550538003673 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003674 PS00211 ABC transporters family signature. 550538003675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 550538003676 catalytic core [active] 550538003677 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 550538003678 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 2.9e-44 550538003679 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 550538003680 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 550538003681 active site 550538003682 catalytic residues [active] 550538003683 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.8e-122 550538003684 PS00545 Aldose 1-epimerase active site. 550538003685 galactokinase; Provisional; Region: PRK05101 550538003686 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 550538003687 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 550538003688 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 1.2e-13 550538003689 HMMPfam hit to PF00288, GHMP kinase, score 3e-19 550538003690 PS00627 GHMP kinases ATP-binding domain. 550538003691 PS00106 Galactokinase signature. 550538003692 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 550538003693 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 550538003694 dimer interface [polypeptide binding]; other site 550538003695 active site 550538003696 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transferase, C-terminal, score 4.9e-105 550538003697 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transferase, N-terminal, score 1.5e-103 550538003698 PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 550538003699 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 550538003700 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 550538003701 NAD binding site [chemical binding]; other site 550538003702 homodimer interface [polypeptide binding]; other site 550538003703 active site 550538003704 substrate binding site [chemical binding]; other site 550538003705 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 8.4e-88 550538003706 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 550538003707 1 probable transmembrane helix predicted for SG0755 by TMHMM2.0 at aa 271-293 550538003708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538003709 ABC transporter signature motif; other site 550538003710 Walker B; other site 550538003711 D-loop; other site 550538003712 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 550538003713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538003714 Walker A/P-loop; other site 550538003715 ATP binding site [chemical binding]; other site 550538003716 Q-loop/lid; other site 550538003717 ABC transporter signature motif; other site 550538003718 Walker B; other site 550538003719 D-loop; other site 550538003720 H-loop/switch region; other site 550538003721 HMMPfam hit to PF00005, ABC transporter related, score 9.7e-51 550538003722 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003723 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 550538003724 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 550538003725 molybdenum-pterin binding domain; Region: Mop; TIGR00638 550538003726 TOBE domain; Region: TOBE; pfam03459 550538003727 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 1.9e-10 550538003728 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 1.8e-15 550538003729 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.7e-15 550538003730 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 550538003731 1 probable transmembrane helix predicted for SG0758 by TMHMM2.0 at aa 42-64 550538003732 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 550538003733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538003734 substrate binding pocket [chemical binding]; other site 550538003735 membrane-bound complex binding site; other site 550538003736 hinge residues; other site 550538003737 PS00430 TonB-dependent receptor proteins signature 1. 550538003738 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.3e-11 550538003739 PS00435 Peroxidases proximal heme-ligand signature. 550538003740 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 550538003741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538003742 dimer interface [polypeptide binding]; other site 550538003743 conserved gate region; other site 550538003744 putative PBP binding loops; other site 550538003745 ABC-ATPase subunit interface; other site 550538003746 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6e-24 550538003747 5 probable transmembrane helices predicted for SG0760 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 136-158 and 197-219 550538003748 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538003749 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 550538003750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538003751 Walker A/P-loop; other site 550538003752 ATP binding site [chemical binding]; other site 550538003753 Q-loop/lid; other site 550538003754 ABC transporter signature motif; other site 550538003755 Walker B; other site 550538003756 D-loop; other site 550538003757 H-loop/switch region; other site 550538003758 molybdenum-pterin binding domain; Region: Mop; TIGR00638 550538003759 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-68 550538003760 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003761 PS00211 ABC transporters family signature. 550538003762 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 9.5e-14 550538003763 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 550538003764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538003765 active site 550538003766 motif I; other site 550538003767 motif II; other site 550538003768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538003769 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 2.5e-93 550538003770 PS01229 Hypothetical cof family signature 2. 550538003771 PS01228 Hypothetical cof family signature 1. 550538003772 6-phosphogluconolactonase; Provisional; Region: PRK11028 550538003773 acyl-CoA thioesterase; Provisional; Region: PRK10531 550538003774 putative pectinesterase; Region: PLN02432; cl01911 550538003775 HMMPfam hit to PF01095, Pectinesterase, catalytic, score 8.2e-07 550538003776 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538003777 imidazolonepropionase; Validated; Region: PRK09356 550538003778 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 550538003779 active site 550538003780 HMMPfam hit to PF01979, Amidohydrolase 1, score 0.00011 550538003781 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 550538003782 putative active site [active] 550538003783 putative metal binding site [ion binding]; other site 550538003784 HMMPfam hit to PF00491, Ureohydrolase, score 1.2e-09 550538003785 PS00147 Arginase family signature 1. 550538003786 PS00148 Arginase family signature 2. 550538003787 histidine utilization repressor; Provisional; Region: PRK14999 550538003788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538003789 DNA-binding site [nucleotide binding]; DNA binding site 550538003790 UTRA domain; Region: UTRA; pfam07702 550538003791 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.6e-23 550538003792 PS00043 Bacterial regulatory proteins, gntR family signature. 550538003793 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 3.8e-41 550538003794 urocanate hydratase; Provisional; Region: PRK05414 550538003795 HMMPfam hit to PF01175, Urocanase, score 0 550538003796 PS01233 Urocanase active site. 550538003797 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 550538003798 active sites [active] 550538003799 tetramer interface [polypeptide binding]; other site 550538003800 HMMPfam hit to PF00221, Phenylalanine/histidine ammonia-lyase, score 4e-259 550538003801 PS00488 Phenylalanine and histidine ammonia-lyases signature. 550538003802 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 550538003803 substrate binding site [chemical binding]; other site 550538003804 HMMPfam hit to PF01161, PEBP, score 1.7e-07 550538003805 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 550538003806 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 550538003807 inhibitor-cofactor binding pocket; inhibition site 550538003808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538003809 catalytic residue [active] 550538003810 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.4e-148 550538003811 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 550538003812 biotin synthase; Provisional; Region: PRK15108 550538003813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538003814 FeS/SAM binding site; other site 550538003815 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 550538003816 HMMPfam hit to PF04055, Radical SAM, score 1.3e-25 550538003817 HMMPfam hit to PF06968, Biotin and thiamin synthesis associated, score 4.2e-53 550538003818 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 550538003819 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 550538003820 substrate-cofactor binding pocket; other site 550538003821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538003822 catalytic residue [active] 550538003823 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 3.6e-88 550538003824 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 550538003825 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 550538003826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538003827 S-adenosylmethionine binding site [chemical binding]; other site 550538003828 HMMPfam hit to PF08241, Methyltransferase type 11, score 9.4e-33 550538003829 AAA domain; Region: AAA_26; pfam13500 550538003830 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 550538003831 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 3.4e-21 550538003832 excinuclease ABC subunit B; Provisional; Region: PRK05298 550538003833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538003834 ATP binding site [chemical binding]; other site 550538003835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538003836 nucleotide binding region [chemical binding]; other site 550538003837 ATP-binding site [chemical binding]; other site 550538003838 Ultra-violet resistance protein B; Region: UvrB; pfam12344 550538003839 UvrB/uvrC motif; Region: UVR; pfam02151 550538003840 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 6.7e-09 550538003841 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003842 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.5e-21 550538003843 HMMPfam hit to PF02151, UvrB/UvrC protein, score 3.1e-14 550538003845 HMMPfam hit to PF00560, Leucine-rich repeat, score 2.9 550538003846 HMMPfam hit to PF00560, Leucine-rich repeat, score 3.4 550538003847 HMMPfam hit to PF00560, Leucine-rich repeat, score 1.8 550538003848 HMMPfam hit to PF00560, Leucine-rich repeat, score 2.5 550538003849 HMMPfam hit to PF00560, Leucine-rich repeat, score 8.6 550538003850 HMMPfam hit to PF00560, Leucine-rich repeat, score 2.4 550538003851 HMMPfam hit to PF00560, Leucine-rich repeat, score 3 550538003852 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 550538003853 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 550538003854 putative substrate binding pocket [chemical binding]; other site 550538003855 dimer interface [polypeptide binding]; other site 550538003856 phosphate binding site [ion binding]; other site 550538003857 HMMPfam hit to PF01933, Protein of unknown function UPF0052 and CofD, score 1.5e-128 550538003858 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 550538003859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538003860 FeS/SAM binding site; other site 550538003861 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 550538003862 HMMPfam hit to PF04055, Radical SAM, score 2.8e-38 550538003863 PS01305 moaA / nifB / pqqE family signature. 550538003864 HMMPfam hit to PF06463, Molybdenum cofactor synthesis C-terminal, score 4.5e-49 550538003865 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 550538003866 MPT binding site; other site 550538003867 trimer interface [polypeptide binding]; other site 550538003868 HMMPfam hit to PF00994, Molybdopterin binding, score 3.2e-44 550538003869 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 550538003870 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 550538003871 trimer interface [polypeptide binding]; other site 550538003872 dimer interface [polypeptide binding]; other site 550538003873 putative active site [active] 550538003874 HMMPfam hit to PF01967, Molybdopterin cofactor biosynthesis MoaC region, score 2.6e-96 550538003875 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 550538003876 MoaE interaction surface [polypeptide binding]; other site 550538003877 MoeB interaction surface [polypeptide binding]; other site 550538003878 thiocarboxylated glycine; other site 550538003879 HMMPfam hit to PF02597, ThiamineS, score 1.1e-27 550538003880 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 550538003881 MoaE homodimer interface [polypeptide binding]; other site 550538003882 MoaD interaction [polypeptide binding]; other site 550538003883 active site residues [active] 550538003884 HMMPfam hit to PF02391, Molybdopterin biosynthesis MoaE, score 9.6e-61 550538003885 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 550538003886 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 550538003887 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 1.2e-55 550538003888 7 probable transmembrane helices predicted for SG0786 by TMHMM2.0 at aa 20-42, 57-76, 88-107, 112-131, 138-160, 165-184 and 209-231 550538003889 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 550538003890 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 550538003891 7 probable transmembrane helices predicted for SG0787 by TMHMM2.0 at aa 21-43, 48-70, 77-99, 104-126, 131-153, 157-176 and 205-227 550538003892 4 probable transmembrane helices predicted for SG0788 by TMHMM2.0 at aa 64-83, 93-115, 120-142 and 157-179 550538003893 4 probable transmembrane helices predicted for SG0789 by TMHMM2.0 at aa 44-66, 81-103, 115-137 and 147-169 550538003894 Predicted integral membrane protein [Function unknown]; Region: COG0392 550538003895 8 probable transmembrane helices predicted for SG0790 by TMHMM2.0 at aa 13-30, 50-72, 85-107, 127-149, 162-184, 204-226, 233-255 and 281-303 550538003896 cardiolipin synthase 2; Provisional; Region: PRK11263 550538003897 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 550538003898 putative active site [active] 550538003899 catalytic site [active] 550538003900 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 550538003901 putative active site [active] 550538003902 catalytic site [active] 550538003903 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 1.3 550538003904 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 2.6e-07 550538003905 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 550538003906 putative catalytic site [active] 550538003907 putative metal binding site [ion binding]; other site 550538003908 putative phosphate binding site [ion binding]; other site 550538003909 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 9.7e-28 550538003910 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 550538003911 4 probable transmembrane helices predicted for SG0793 by TMHMM2.0 at aa 13-32, 36-58, 79-96 and 100-119 550538003912 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 550538003913 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 550538003914 6 probable transmembrane helices predicted for SG0794 by TMHMM2.0 at aa 24-46, 173-195, 223-245, 255-277, 284-303 and 338-360 550538003915 HMMPfam hit to PF01061, ABC-2 type transporter, score 3.3e-42 550538003916 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 550538003917 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 550538003918 6 probable transmembrane helices predicted for SG0795 by TMHMM2.0 at aa 26-48, 181-203, 230-252, 262-284, 291-313 and 347-369 550538003919 HMMPfam hit to PF01061, ABC-2 type transporter, score 6.3e-24 550538003920 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 550538003921 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 550538003922 Walker A/P-loop; other site 550538003923 ATP binding site [chemical binding]; other site 550538003924 Q-loop/lid; other site 550538003925 ABC transporter signature motif; other site 550538003926 Walker B; other site 550538003927 D-loop; other site 550538003928 H-loop/switch region; other site 550538003929 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 550538003930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 550538003931 Walker A/P-loop; other site 550538003932 ATP binding site [chemical binding]; other site 550538003933 Q-loop/lid; other site 550538003934 ABC transporter signature motif; other site 550538003935 Walker B; other site 550538003936 D-loop; other site 550538003937 H-loop/switch region; other site 550538003938 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-47 550538003939 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003940 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-38 550538003941 PS00211 ABC transporters family signature. 550538003942 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003943 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 550538003944 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 550538003945 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538003946 HMMPfam hit to PF00529, Secretion protein HlyD, score 7.2e-20 550538003947 1 probable transmembrane helix predicted for SG0797 by TMHMM2.0 at aa 5-27 550538003948 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 550538003949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538003950 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 550538003951 HMMPfam hit to PF09209, Transcriptional regulator, YbiH, C-terminal, score 1e-40 550538003952 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 5.1e-16 550538003953 PS01081 Bacterial regulatory proteins, tetR family signature. 550538003954 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 550538003955 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 550538003956 ATP binding site [chemical binding]; other site 550538003957 Mg++ binding site [ion binding]; other site 550538003958 motif III; other site 550538003959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538003960 nucleotide binding region [chemical binding]; other site 550538003961 ATP-binding site [chemical binding]; other site 550538003962 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.5e-74 550538003963 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003964 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 550538003965 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.9e-34 550538003966 the sequence has been checked and is believed to be correct 550538003967 glycosyl transferase family protein; Provisional; Region: PRK08136 550538003968 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 550538003969 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 9.8e-26 550538003970 hypothetical protein; Provisional; Region: PRK10259 550538003971 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 5.8e-34 550538003972 hypothetical protein; Provisional; Region: PRK11019 550538003973 HMMPfam hit to PF01258, Zinc finger, DksA/TraR C4-type, score 3.5e-33 550538003974 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 550538003975 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 550538003976 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 550538003977 HMMPfam hit to PF05971, Protein of unknown function DUF890, score 6.8e-209 550538003978 putative mechanosensitive channel protein; Provisional; Region: PRK11465 550538003979 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538003980 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 7e-63 550538003981 11 probable transmembrane helices predicted for SG0805 by TMHMM2.0 at aa 5-27, 136-158, 179-201, 216-238, 267-284, 294-313, 333-355, 370-392, 427-449, 464-486 and 507-529 550538003982 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 550538003983 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 550538003984 Walker A/P-loop; other site 550538003985 ATP binding site [chemical binding]; other site 550538003986 Q-loop/lid; other site 550538003987 ABC transporter signature motif; other site 550538003988 Walker B; other site 550538003989 D-loop; other site 550538003990 H-loop/switch region; other site 550538003991 HMMPfam hit to PF00005, ABC transporter related, score 1e-70 550538003992 PS00211 ABC transporters family signature. 550538003993 PS00017 ATP/GTP-binding site motif A (P-loop). 550538003994 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538003995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538003996 dimer interface [polypeptide binding]; other site 550538003997 conserved gate region; other site 550538003998 putative PBP binding loops; other site 550538003999 ABC-ATPase subunit interface; other site 550538004000 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.6e-39 550538004001 5 probable transmembrane helices predicted for SG0807 by TMHMM2.0 at aa 20-42, 55-77, 92-114, 155-177 and 187-209 550538004002 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538004003 note the frame shift mutation following codon 70 550538004004 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 3.5e-93 550538004005 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 550538004006 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 550538004007 dimerization interface [polypeptide binding]; other site 550538004008 DPS ferroxidase diiron center [ion binding]; other site 550538004009 ion pore; other site 550538004010 HMMPfam hit to PF00210, Ferritin and Dps, score 9.4e-13 550538004011 PS00819 Dps protein family signature 2. 550538004012 PS00818 Dps protein family signature 1. 550538004013 threonine and homoserine efflux system; Provisional; Region: PRK10532 550538004014 EamA-like transporter family; Region: EamA; pfam00892 550538004015 10 probable transmembrane helices predicted for SG0811 by TMHMM2.0 at aa 7-24, 37-59, 72-89, 93-115, 122-139, 143-165, 177-199, 203-225, 238-257 and 261-283 550538004016 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 6.7e-19 550538004017 outer membrane protein X; Provisional; Region: ompX; PRK09408 550538004018 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 4.6e-18 550538004019 1 probable transmembrane helix predicted for SG0812 by TMHMM2.0 at aa 7-29 550538004020 PS00694 Enterobacterial virulence outer membrane protein signature 1. 550538004021 PS00695 Enterobacterial virulence outer membrane protein signature 2. 550538004022 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 550538004023 Sulfatase; Region: Sulfatase; pfam00884 550538004024 HMMPfam hit to PF00884, Sulphatase, score 3.6e-68 550538004025 4 probable transmembrane helices predicted for SG0813 by TMHMM2.0 at aa 32-54, 63-85, 105-127 and 144-166 550538004026 manganese transport regulator MntR; Provisional; Region: PRK11050 550538004027 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 550538004028 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 550538004029 HMMPfam hit to PF01325, Iron dependent repressor, score 1.9e-05 550538004030 HMMPfam hit to PF02742, Iron dependent repressor, score 6.6e-07 550538004031 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 550538004032 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 550538004033 transmembrane helices; other site 550538004034 HMMPfam hit to PF03600, Divalent ion symporter, score 3.9e-07 550538004035 8 probable transmembrane helices predicted for SG0815 by TMHMM2.0 at aa 22-44, 64-86, 142-164, 203-222, 226-248, 261-283, 293-315 and 327-349 550538004036 L,D-transpeptidase; Provisional; Region: PRK10260 550538004037 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 550538004038 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 9.2e-68 550538004039 1 probable transmembrane helix predicted for SG0816 by TMHMM2.0 at aa 7-29 550538004040 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 550538004041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538004042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004043 Walker A/P-loop; other site 550538004044 ATP binding site [chemical binding]; other site 550538004045 ABC transporter signature motif; other site 550538004046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538004047 Walker B; other site 550538004048 ABC transporter; Region: ABC_tran_2; pfam12848 550538004049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538004050 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-40 550538004051 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004052 HMMPfam hit to PF00005, ABC transporter related, score 9.7e-46 550538004053 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004054 note the frame shift mutation following codon 73 550538004055 the sequence has been checked and is believed to be correct 550538004056 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 3.7e-48 550538004058 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 550538004059 HMMPfam hit to PF07350, Protein of unknown function DUF1479, score 0 550538004060 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 550538004061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538004062 active site 550538004063 motif I; other site 550538004064 motif II; other site 550538004065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538004066 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 8.2e-65 550538004067 PS01229 Hypothetical cof family signature 2. 550538004068 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 550538004069 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 550538004070 dimer interface [polypeptide binding]; other site 550538004071 active site 550538004072 glycine loop; other site 550538004073 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 4e-22 550538004074 PS00850 Glycine radical signature. 550538004075 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 550538004076 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 550538004077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538004078 FeS/SAM binding site; other site 550538004079 HMMPfam hit to PF04055, Radical SAM, score 2.6e-12 550538004080 PS01087 Radical activating enzymes signature. 550538004081 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 550538004082 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 550538004083 ATP binding site [chemical binding]; other site 550538004084 substrate interface [chemical binding]; other site 550538004085 HMMPfam hit to PF05237, MoeZ/MoeB, score 5.8e-35 550538004086 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 1.1e-63 550538004087 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 550538004088 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 550538004089 dimer interface [polypeptide binding]; other site 550538004090 putative functional site; other site 550538004091 putative MPT binding site; other site 550538004092 HMMPfam hit to PF03454, MoeA, C-terminal, domain IV, score 9.2e-26 550538004093 HMMPfam hit to PF00994, Molybdopterin binding, score 7e-52 550538004094 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 550538004095 HMMPfam hit to PF03453, MoeA, N-terminal, domain I and II, score 3.3e-83 550538004096 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 550538004097 catalytic nucleophile [active] 550538004098 HMMPfam hit to PF01112, Peptidase T2, asparaginase 2, score 2.4e-170 550538004099 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 550538004100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538004101 Walker A/P-loop; other site 550538004102 ATP binding site [chemical binding]; other site 550538004103 Q-loop/lid; other site 550538004104 ABC transporter signature motif; other site 550538004105 Walker B; other site 550538004106 D-loop; other site 550538004107 H-loop/switch region; other site 550538004108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 550538004109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538004110 Walker A/P-loop; other site 550538004111 ATP binding site [chemical binding]; other site 550538004112 Q-loop/lid; other site 550538004113 ABC transporter signature motif; other site 550538004114 Walker B; other site 550538004115 D-loop; other site 550538004116 H-loop/switch region; other site 550538004117 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 550538004118 HMMPfam hit to PF00005, ABC transporter related, score 5.2e-58 550538004119 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004120 PS00211 ABC transporters family signature. 550538004121 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 5.8e-07 550538004122 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-59 550538004123 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004124 PS00211 ABC transporters family signature. 550538004125 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 2.5e-09 550538004126 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 550538004127 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 550538004128 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 8.6e-94 550538004129 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 550538004130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538004131 dimer interface [polypeptide binding]; other site 550538004132 conserved gate region; other site 550538004133 putative PBP binding loops; other site 550538004134 ABC-ATPase subunit interface; other site 550538004135 6 probable transmembrane helices predicted for SG0831 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-189, 227-249 and 278-300 550538004136 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-55 550538004137 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538004138 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 550538004139 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 550538004140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538004141 dimer interface [polypeptide binding]; other site 550538004142 conserved gate region; other site 550538004143 putative PBP binding loops; other site 550538004144 ABC-ATPase subunit interface; other site 550538004145 6 probable transmembrane helices predicted for SG0832 by TMHMM2.0 at aa 39-61, 107-129, 136-158, 163-185, 209-231 and 266-288 550538004146 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.3e-47 550538004147 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538004148 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 550538004149 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 550538004150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538004151 FeS/SAM binding site; other site 550538004152 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 0.019 550538004153 HMMPfam hit to PF04055, Radical SAM, score 6.2e-29 550538004154 PS01278 Uncharacterized protein family UPF0004 signature. 550538004155 HMMPfam hit to PF00919, Protein of unknown function UPF0004, N-terminal, score 8.2e-42 550538004156 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 550538004157 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 550538004158 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 1.1e-05 550538004159 Salmonella Pathogenicity Island 14: SPI-14 550538004160 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 550538004161 Ligand binding site [chemical binding]; other site 550538004162 Electron transfer flavoprotein domain; Region: ETF; pfam01012 550538004163 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/beta-subunit, N-terminal, score 7.1e-58 550538004164 PS01065 Electron transfer flavoprotein beta-subunit signature. 550538004165 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 550538004166 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 550538004167 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 550538004168 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/beta-subunit, N-terminal, score 1.3e-27 550538004169 HMMPfam hit to PF00766, Electron transfer flavoprotein, alpha subunit, C-terminal, score 1.9e-55 550538004170 PS00696 Electron transfer flavoprotein alpha-subunit signature. 550538004171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 550538004172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 550538004173 active site 550538004174 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 5e-13 550538004175 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase/oxidase, central region, score 3.7e-23 550538004176 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 1e-35 550538004177 PS00073 Acyl-CoA dehydrogenases signature 2. 550538004178 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 550538004179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538004180 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 550538004181 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 550538004182 HMMPfam hit to PF01494, Monooxygenase, FAD-binding, score 2.7e-08 550538004183 HMMPfam hit to PF05187, Electron transfer flavoprotein-ubiquinone oxidoreductase, score 2.8e-73 550538004184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538004185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538004186 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 550538004187 putative dimerization interface [polypeptide binding]; other site 550538004188 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.3e-36 550538004189 PS00201 Flavodoxin signature. 550538004190 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2e-14 550538004191 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 550538004192 3 probable transmembrane helices predicted for SG0841 by TMHMM2.0 at aa 7-29, 53-75 and 96-118 550538004193 HMMPfam hit to PF03600, Divalent ion symporter, score 1.8e-23 550538004194 Appears to be the remnant following a large deletion event 550538004195 HMMPfam hit to PF03811, Insertion element protein, score 1.1e-28 550538004196 HMMPfam hit to PF07995, Glucose sorbosone dehydrogenase, score 1.2e-44 550538004197 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 550538004198 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 550538004199 putative C-terminal domain interface [polypeptide binding]; other site 550538004200 putative GSH binding site (G-site) [chemical binding]; other site 550538004201 putative dimer interface [polypeptide binding]; other site 550538004202 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 550538004203 putative N-terminal domain interface [polypeptide binding]; other site 550538004204 putative dimer interface [polypeptide binding]; other site 550538004205 putative substrate binding pocket (H-site) [chemical binding]; other site 550538004206 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 3.8e-10 550538004207 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 7.3e-11 550538004208 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 550538004209 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 550538004210 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 550538004211 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 1.5e-149 550538004212 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 1.1e-38 550538004213 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 550538004214 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 550538004215 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538004216 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 4.7e-70 550538004217 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.2e-16 550538004218 PS00894 Bacterial regulatory proteins, deoR family signature. 550538004219 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 550538004220 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 550538004221 active site 550538004222 4 probable transmembrane helices predicted for SG0846 by TMHMM2.0 at aa 26-48, 60-82, 126-148 and 155-177 550538004223 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 1.3e-29 550538004224 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 550538004225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538004226 putative substrate translocation pore; other site 550538004227 12 probable transmembrane helices predicted for SG0847 by TMHMM2.0 at aa 16-38, 53-72, 84-101, 111-130, 142-164, 169-188, 220-242, 257-279, 286-308, 313-335, 348-367 and 377-399 550538004228 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.4e-28 550538004229 PS00216 Sugar transport proteins signature 1. 550538004230 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 550538004231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538004232 active site 550538004233 motif I; other site 550538004234 motif II; other site 550538004235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538004236 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 4.3e-66 550538004237 PS01229 Hypothetical cof family signature 2. 550538004238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538004239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538004240 putative substrate translocation pore; other site 550538004241 12 probable transmembrane helices predicted for SG0849 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-124, 145-167, 171-190, 211-233, 253-275, 282-301, 305-327, 340-362 and 367-389 550538004242 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.9e-23 550538004243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 550538004244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538004245 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 550538004246 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 7.6e-09 550538004247 putative transporter; Provisional; Region: PRK04972 550538004248 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 550538004249 TrkA-C domain; Region: TrkA_C; pfam02080 550538004250 TrkA-C domain; Region: TrkA_C; pfam02080 550538004251 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 550538004252 9 probable transmembrane helices predicted for SG0851 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181, 383-402, 406-428, 449-471, 476-498 and 535-557 550538004253 HMMPfam hit to PF06826, YidE/YbjL duplication, score 2.4e-62 550538004254 HMMPfam hit to PF02080, TrkA-C, score 6.3e-12 550538004255 HMMPfam hit to PF02080, TrkA-C, score 4.8e-11 550538004256 HMMPfam hit to PF06826, YidE/YbjL duplication, score 3e-67 550538004257 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 550538004258 4 probable transmembrane helices predicted for SG0852 by TMHMM2.0 at aa 7-29, 34-56, 61-83 and 93-115 550538004259 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 550538004260 GSH binding site [chemical binding]; other site 550538004261 catalytic residues [active] 550538004262 HMMPfam hit to PF00462, Glutaredoxin, score 2.1e-15 550538004263 PS00195 Glutaredoxin active site. 550538004264 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 550538004265 HMMPfam hit to PF07214, Protein of unknown function DUF1418, score 3.6e-72 550538004266 2 probable transmembrane helices predicted for SG0854 by TMHMM2.0 at aa 13-35 and 45-67 550538004267 the sequence has been checked and is believed to be correct 550538004268 HMMPfam hit to PF00881, Nitroreductase, score 7.8e-36 550538004269 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 550538004270 RimK-like ATP-grasp domain; Region: RimK; pfam08443 550538004271 HMMPfam hit to PF08443, ATP-grasp fold, RimK-type, score 2.2e-112 550538004272 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 550538004273 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 550538004274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 550538004275 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 3.8e-11 550538004276 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 550538004277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004278 Walker A/P-loop; other site 550538004279 ATP binding site [chemical binding]; other site 550538004280 Q-loop/lid; other site 550538004281 ABC transporter signature motif; other site 550538004282 Walker B; other site 550538004283 D-loop; other site 550538004284 H-loop/switch region; other site 550538004285 TOBE domain; Region: TOBE_2; pfam08402 550538004286 HMMPfam hit to PF00005, ABC transporter related, score 4e-65 550538004287 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004288 PS00211 ABC transporters family signature. 550538004289 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 6.8e-25 550538004290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538004291 dimer interface [polypeptide binding]; other site 550538004292 conserved gate region; other site 550538004293 putative PBP binding loops; other site 550538004294 ABC-ATPase subunit interface; other site 550538004295 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 550538004296 6 probable transmembrane helices predicted for SG0860 by TMHMM2.0 at aa 31-52, 100-122, 135-157, 185-207, 228-250 and 284-306 550538004297 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.5e-33 550538004298 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538004299 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 550538004300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538004301 dimer interface [polypeptide binding]; other site 550538004302 conserved gate region; other site 550538004303 putative PBP binding loops; other site 550538004304 ABC-ATPase subunit interface; other site 550538004305 6 probable transmembrane helices predicted for SG0861 by TMHMM2.0 at aa 13-35, 69-91, 104-126, 141-163, 184-206 and 244-266 550538004306 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2e-06 550538004307 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538004308 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 550538004309 4 probable transmembrane helices predicted for SG0862 by TMHMM2.0 at aa 13-35, 60-82, 89-111 and 126-148 550538004310 the sequence has been checked and is believed to be correct 550538004311 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 5.8e-06 550538004312 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 550538004313 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 1.6e-92 550538004314 11 probable transmembrane helices predicted for SG0864 by TMHMM2.0 at aa 15-37, 44-66, 103-125, 132-154, 159-181, 233-255, 270-292, 330-352, 356-378, 385-407 and 422-444 550538004315 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 550538004316 active site 550538004317 P-loop; other site 550538004318 phosphorylation site [posttranslational modification] 550538004319 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 4.6e-08 550538004320 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 550538004321 Sulfatase; Region: Sulfatase; cl17466 550538004322 HMMPfam hit to PF00884, Sulphatase, score 1.2e-16 550538004323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538004324 substrate binding pocket [chemical binding]; other site 550538004325 membrane-bound complex binding site; other site 550538004326 hinge residues; other site 550538004327 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 2.4e-90 550538004328 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 550538004329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538004330 dimer interface [polypeptide binding]; other site 550538004331 conserved gate region; other site 550538004332 putative PBP binding loops; other site 550538004333 ABC-ATPase subunit interface; other site 550538004334 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.9e-09 550538004335 5 probable transmembrane helices predicted for SG0868 by TMHMM2.0 at aa 15-37, 46-68, 83-105, 155-174 and 189-211 550538004336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538004338 dimer interface [polypeptide binding]; other site 550538004339 conserved gate region; other site 550538004340 putative PBP binding loops; other site 550538004341 ABC-ATPase subunit interface; other site 550538004342 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9e-19 550538004343 4 probable transmembrane helices predicted for SG0869 by TMHMM2.0 at aa 10-32, 45-67, 101-118 and 201-223 550538004344 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538004345 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 550538004346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538004347 substrate binding pocket [chemical binding]; other site 550538004348 membrane-bound complex binding site; other site 550538004349 hinge residues; other site 550538004350 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 2.6e-95 550538004351 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 550538004352 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 550538004353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004354 Walker A/P-loop; other site 550538004355 ATP binding site [chemical binding]; other site 550538004356 Q-loop/lid; other site 550538004357 ABC transporter signature motif; other site 550538004358 Walker B; other site 550538004359 D-loop; other site 550538004360 H-loop/switch region; other site 550538004361 HMMPfam hit to PF00005, ABC transporter related, score 3.4e-76 550538004362 PS00211 ABC transporters family signature. 550538004363 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004364 putative lipoprotein; Provisional; Region: PRK10533 550538004365 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538004366 hypothetical protein; Provisional; Region: PRK02877 550538004367 HMMPfam hit to PF01906, Protein of unknown function DUF74, score 1.6e-65 550538004368 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 550538004369 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 550538004370 amidase catalytic site [active] 550538004371 Zn binding residues [ion binding]; other site 550538004372 substrate binding site [chemical binding]; other site 550538004373 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, family 2, score 1.1e-41 550538004374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 550538004375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 550538004376 NAD(P) binding site [chemical binding]; other site 550538004377 active site 550538004378 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 7.2e-19 550538004379 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 550538004380 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 550538004381 putative NAD(P) binding site [chemical binding]; other site 550538004382 putative active site [active] 550538004383 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 550538004384 1 probable transmembrane helix predicted for SG0876 by TMHMM2.0 at aa 438-460 550538004385 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 4.3e-11 550538004386 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 550538004387 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 550538004388 tetramer interface [polypeptide binding]; other site 550538004389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538004390 catalytic residue [active] 550538004391 HMMPfam hit to PF01212, Aromatic amino acid beta-eliminating lyase/threonine aldolase, score 1.2e-153 550538004392 pyruvate dehydrogenase; Provisional; Region: PRK09124 550538004393 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 550538004394 PYR/PP interface [polypeptide binding]; other site 550538004395 dimer interface [polypeptide binding]; other site 550538004396 tetramer interface [polypeptide binding]; other site 550538004397 TPP binding site [chemical binding]; other site 550538004398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 550538004399 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 550538004400 TPP-binding site [chemical binding]; other site 550538004401 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 7.2e-61 550538004402 PS00187 Thiamine pyrophosphate enzymes signature. 550538004403 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 2.4e-47 550538004404 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 3.8e-81 550538004405 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 550538004406 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 550538004407 FAD binding pocket [chemical binding]; other site 550538004408 FAD binding motif [chemical binding]; other site 550538004409 phosphate binding motif [ion binding]; other site 550538004410 beta-alpha-beta structure motif; other site 550538004411 NAD binding pocket [chemical binding]; other site 550538004412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 550538004413 catalytic loop [active] 550538004414 iron binding site [ion binding]; other site 550538004415 HMMPfam hit to PF00111, Ferredoxin, score 3.1e-20 550538004416 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 1e-07 550538004417 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 7.5e-09 550538004418 hybrid cluster protein; Provisional; Region: PRK05290 550538004419 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 550538004420 ACS interaction site; other site 550538004421 CODH interaction site; other site 550538004422 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 550538004423 hybrid metal cluster; other site 550538004424 HMMPfam hit to PF03063, Prismane, score 9.4e-259 550538004425 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004426 Predicted membrane protein [Function unknown]; Region: COG2431 550538004427 HMMPfam hit to PF03956, Protein of unknown function DUF340, prokaryotic membrane, score 1.4e-87 550538004428 6 probable transmembrane helices predicted for SG0881 by TMHMM2.0 at aa 25-47, 75-97, 102-119, 131-153, 168-190 and 239-261 550538004429 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 550538004430 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 550538004431 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 550538004432 putative active site [active] 550538004433 putative metal-binding site [ion binding]; other site 550538004434 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004435 Protein of unknown function (DUF535); Region: DUF535; pfam04393 550538004436 HMMPfam hit to PF04393, Protein of unknown function DUF535, score 1.6e-93 550538004437 note the frame shift mutation following codon 26 550538004438 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.9e-07 550538004439 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 550538004440 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 550538004441 Walker A/P-loop; other site 550538004442 ATP binding site [chemical binding]; other site 550538004443 Q-loop/lid; other site 550538004444 ABC transporter signature motif; other site 550538004445 Walker B; other site 550538004446 D-loop; other site 550538004447 H-loop/switch region; other site 550538004448 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 550538004449 FtsX-like permease family; Region: FtsX; pfam02687 550538004450 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-60 550538004451 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004452 PS00211 ABC transporters family signature. 550538004453 5 probable transmembrane helices predicted for SG0886 by TMHMM2.0 at aa 270-292, 418-437, 524-546, 572-594 and 609-631 550538004454 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 6.5e-53 550538004455 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 550538004456 DNA-binding site [nucleotide binding]; DNA binding site 550538004457 RNA-binding motif; other site 550538004458 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 1.7e-39 550538004459 PS00352 'Cold-shock' DNA-binding domain signature. 550538004460 Uncharacterized conserved protein [Function unknown]; Region: COG2127 550538004461 HMMPfam hit to PF02617, Adaptor protein ClpS, core, score 6.3e-49 550538004462 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 550538004463 Clp amino terminal domain; Region: Clp_N; pfam02861 550538004464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538004465 Walker A motif; other site 550538004466 ATP binding site [chemical binding]; other site 550538004467 Walker B motif; other site 550538004468 arginine finger; other site 550538004469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538004470 Walker A motif; other site 550538004471 ATP binding site [chemical binding]; other site 550538004472 Walker B motif; other site 550538004473 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 550538004474 HMMPfam hit to PF02861, Clp, N-terminal, score 7.5e-17 550538004475 HMMPfam hit to PF00004, AAA ATPase, core, score 2.4e-20 550538004476 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004477 PS00870 Chaperonins clpA/B signature 1. 550538004478 HMMPfam hit to PF07724, ATPase AAA-2, score 1.7e-88 550538004479 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004480 PS00871 Chaperonins clpA/B signature 2. 550538004481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 550538004482 DNA binding site [nucleotide binding] 550538004483 active site 550538004484 Int/Topo IB signature motif; other site 550538004485 Isochorismatase family; Region: Isochorismatase; pfam00857 550538004486 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 550538004487 catalytic triad [active] 550538004488 dimer interface [polypeptide binding]; other site 550538004489 conserved cis-peptide bond; other site 550538004490 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 7.8e-21 550538004491 Pirin-related protein [General function prediction only]; Region: COG1741 550538004492 Pirin; Region: Pirin; pfam02678 550538004493 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 550538004494 HMMPfam hit to PF05726, Pirin, C-terminal, score 9.3e-48 550538004495 HMMPfam hit to PF02678, Pirin, N-terminal, score 1.2e-55 550538004496 LysR family transcriptional regulator; Provisional; Region: PRK14997 550538004497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538004498 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 550538004499 putative effector binding pocket; other site 550538004500 putative dimerization interface [polypeptide binding]; other site 550538004501 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.7e-14 550538004502 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.6e-41 550538004503 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 550538004504 rRNA binding site [nucleotide binding]; other site 550538004505 predicted 30S ribosome binding site; other site 550538004506 HMMPfam hit to PF01176, S1, IF1 type, score 2.1e-37 550538004507 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 550538004508 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA-protein transferase, score 1.3e-108 550538004509 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 550538004510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 550538004511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004512 Walker A/P-loop; other site 550538004513 ATP binding site [chemical binding]; other site 550538004514 Q-loop/lid; other site 550538004515 ABC transporter signature motif; other site 550538004516 Walker B; other site 550538004517 D-loop; other site 550538004518 H-loop/switch region; other site 550538004519 HMMPfam hit to PF00005, ABC transporter related, score 5.2e-61 550538004520 PS00211 ABC transporters family signature. 550538004521 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004522 6 probable transmembrane helices predicted for SG0899 by TMHMM2.0 at aa 20-42, 47-69, 133-155, 160-182, 246-268 and 278-300 550538004523 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 550538004524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 550538004525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004526 Walker A/P-loop; other site 550538004527 ATP binding site [chemical binding]; other site 550538004528 Q-loop/lid; other site 550538004529 ABC transporter signature motif; other site 550538004530 Walker B; other site 550538004531 D-loop; other site 550538004532 H-loop/switch region; other site 550538004533 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-68 550538004534 PS00211 ABC transporters family signature. 550538004535 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004536 6 probable transmembrane helices predicted for SG0900 by TMHMM2.0 at aa 24-46, 61-80, 137-159, 163-185, 245-267 and 282-304 550538004537 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.8e-48 550538004538 thioredoxin reductase; Provisional; Region: PRK10262 550538004539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538004540 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538004541 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.2e-54 550538004542 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.1e-25 550538004543 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 550538004544 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 550538004545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538004546 putative DNA binding site [nucleotide binding]; other site 550538004547 putative Zn2+ binding site [ion binding]; other site 550538004548 AsnC family; Region: AsnC_trans_reg; pfam01037 550538004549 PS00519 Bacterial regulatory proteins, asnC family signature. 550538004550 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 5.2e-31 550538004551 DNA translocase FtsK; Provisional; Region: PRK10263 550538004552 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 550538004553 DNA translocase FtsK; Provisional; Region: PRK10263 550538004554 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 550538004555 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 550538004556 5 probable transmembrane helices predicted for SG0903 by TMHMM2.0 at aa 22-44, 75-97, 110-132, 137-158 and 165-187 550538004557 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 3.6e-105 550538004558 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004559 periplasmic chaperone LolA; Region: lolA; TIGR00547 550538004560 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 550538004561 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein LolA, score 3.7e-78 550538004562 recombination factor protein RarA; Reviewed; Region: PRK13342 550538004563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538004564 Walker A motif; other site 550538004565 ATP binding site [chemical binding]; other site 550538004566 Walker B motif; other site 550538004567 arginine finger; other site 550538004568 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 550538004569 HMMPfam hit to PF00004, AAA ATPase, core, score 4.1e-25 550538004570 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004571 seryl-tRNA synthetase; Provisional; Region: PRK05431 550538004572 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 550538004573 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 550538004574 dimer interface [polypeptide binding]; other site 550538004575 active site 550538004576 motif 1; other site 550538004577 motif 2; other site 550538004578 motif 3; other site 550538004579 HMMPfam hit to PF02403, Seryl-tRNA synthetase, class IIa, N-terminal, score 1e-46 550538004580 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 3.4e-68 550538004581 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538004582 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 550538004583 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 550538004584 putative [Fe4-S4] binding site [ion binding]; other site 550538004585 putative molybdopterin cofactor binding site [chemical binding]; other site 550538004586 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 550538004587 putative molybdopterin cofactor binding site; other site 550538004588 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 2e-17 550538004589 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538004590 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.9e-184 550538004591 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538004592 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 5.6e-38 550538004593 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538004594 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 550538004595 4Fe-4S binding domain; Region: Fer4; pfam00037 550538004596 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.5e-07 550538004597 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538004598 PS00190 Cytochrome c family heme-binding site signature. 550538004599 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 550538004600 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 9.6e-163 550538004601 8 probable transmembrane helices predicted for SG0909 by TMHMM2.0 at aa 10-32, 44-66, 88-107, 114-134, 149-171, 178-200, 227-246 and 253-275 550538004602 putative MFS family transporter protein; Provisional; Region: PRK03633 550538004603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538004604 putative substrate translocation pore; other site 550538004605 11 probable transmembrane helices predicted for SG0910 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 100-119, 131-150, 160-182, 205-227, 237-259, 272-294, 325-344 and 351-373 550538004606 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.4e-23 550538004607 PS00237 G-protein coupled receptors signature. 550538004608 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538004609 inner membrane transporter YjeM; Provisional; Region: PRK15238 550538004610 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.0024 550538004611 11 probable transmembrane helices predicted for SG0911 by TMHMM2.0 at aa 10-29, 36-58, 127-146, 158-180, 195-217, 238-260, 287-309, 340-362, 377-399, 412-434 and 444-466 550538004612 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 550538004613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538004614 FeS/SAM binding site; other site 550538004615 HMMPfam hit to PF04055, Radical SAM, score 4e-27 550538004616 PS01087 Radical activating enzymes signature. 550538004617 PS00190 Cytochrome c family heme-binding site signature. 550538004618 integrase; Provisional; Region: int; PHA02601 550538004619 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 550538004620 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 550538004621 Pyruvate formate lyase 1; Region: PFL1; cd01678 550538004622 coenzyme A binding site [chemical binding]; other site 550538004623 active site 550538004624 catalytic residues [active] 550538004625 glycine loop; other site 550538004626 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 1.8e-63 550538004627 PS00850 Glycine radical signature. 550538004628 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 550538004629 formate transporter; Provisional; Region: PRK10805 550538004630 HMMPfam hit to PF01226, Formate/nitrite transporter, score 4e-176 550538004631 6 probable transmembrane helices predicted for SG0916 by TMHMM2.0 at aa 35-57, 77-99, 119-141, 161-183, 195-217 and 256-278 550538004632 PS01006 Formate and nitrite transporters signature 2. 550538004633 PS01005 Formate and nitrite transporters signature 1. 550538004634 uncharacterized domain; Region: TIGR00702 550538004635 YcaO-like family; Region: YcaO; pfam02624 550538004636 HMMPfam hit to PF02624, YcaO-like, score 3.4e-160 550538004637 Predicted membrane protein [Function unknown]; Region: COG2323 550538004638 3 probable transmembrane helices predicted for SG0918 by TMHMM2.0 at aa 15-37, 50-69 and 74-91 550538004639 HMMPfam hit to PF04239, Protein of unknown function DUF421, score 9.3e-26 550538004640 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 550538004641 homodimer interface [polypeptide binding]; other site 550538004642 substrate-cofactor binding pocket; other site 550538004643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538004644 catalytic residue [active] 550538004645 HMMPfam hit to PF00266, Aminotransferase, class V, score 5.1e-84 550538004646 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 550538004647 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 550538004648 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 550538004649 hinge; other site 550538004650 active site 550538004651 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 1.8e-223 550538004652 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004653 PS00104 EPSP synthase signature 1. 550538004654 PS00885 EPSP synthase signature 2. 550538004655 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 550538004656 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538004657 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 4.6e-27 550538004658 cytidylate kinase; Provisional; Region: cmk; PRK00023 550538004659 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 550538004660 CMP-binding site; other site 550538004661 The sites determining sugar specificity; other site 550538004662 HMMPfam hit to PF02224, Cytidylate kinase region, score 1.2e-93 550538004663 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 550538004664 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 550538004665 RNA binding site [nucleotide binding]; other site 550538004666 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 550538004667 RNA binding site [nucleotide binding]; other site 550538004668 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 550538004669 RNA binding site [nucleotide binding]; other site 550538004670 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 550538004671 RNA binding site [nucleotide binding]; other site 550538004672 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 550538004673 RNA binding site [nucleotide binding]; other site 550538004674 HMMPfam hit to PF00575, S1, RNA binding, score 1.5e-12 550538004675 HMMPfam hit to PF00575, S1, RNA binding, score 1.2e-17 550538004676 HMMPfam hit to PF00575, S1, RNA binding, score 4e-31 550538004677 HMMPfam hit to PF00575, S1, RNA binding, score 4.2e-30 550538004678 HMMPfam hit to PF00575, S1, RNA binding, score 5.8e-26 550538004679 HMMPfam hit to PF00575, S1, RNA binding, score 2.2e-26 550538004680 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 550538004681 IHF dimer interface [polypeptide binding]; other site 550538004682 IHF - DNA interface [nucleotide binding]; other site 550538004683 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 9.2e-47 550538004684 PS00045 Bacterial histone-like DNA-binding proteins signature. 550538004685 ComEC family competence protein; Provisional; Region: PRK11539 550538004686 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 550538004687 Competence protein; Region: Competence; pfam03772 550538004688 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 550538004689 11 probable transmembrane helices predicted for SG0925 by TMHMM2.0 at aa 5-22, 26-43, 50-69, 224-246, 259-281, 301-323, 328-346, 361-383, 390-412, 427-449 and 469-491 550538004690 HMMPfam hit to PF03772, ComEC/Rec2-related protein, score 2.3e-76 550538004691 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.6e-12 550538004692 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 550538004693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 550538004694 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 550538004695 Walker A/P-loop; other site 550538004696 ATP binding site [chemical binding]; other site 550538004697 Q-loop/lid; other site 550538004698 ABC transporter signature motif; other site 550538004699 Walker B; other site 550538004700 D-loop; other site 550538004701 H-loop/switch region; other site 550538004702 5 probable transmembrane helices predicted for SG0926 by TMHMM2.0 at aa 21-43, 63-94, 140-162, 167-186 and 245-267 550538004703 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 6.5e-69 550538004704 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-62 550538004705 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004706 PS00211 ABC transporters family signature. 550538004707 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 550538004708 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 550538004709 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 5.5e-163 550538004710 1 probable transmembrane helix predicted for SG0927 by TMHMM2.0 at aa 12-34 550538004711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 550538004712 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 550538004713 HMMPfam hit to PF06224, Protein of unknown function DUF1006, score 1.1e-237 550538004714 hypothetical protein; Provisional; Region: PRK11827 550538004715 HMMPfam hit to PF03966, Protein of unknown function DUF343, score 1e-14 550538004716 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 550538004717 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 550538004718 Ligand binding site; other site 550538004719 oligomer interface; other site 550538004720 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 5.8e-96 550538004721 hypothetical protein; Provisional; Region: PRK10593 550538004722 Uncharacterized conserved protein [Function unknown]; Region: COG1434 550538004723 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 550538004724 putative active site [active] 550538004725 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 5.9e-47 550538004726 2 probable transmembrane helices predicted for SG0932 by TMHMM2.0 at aa 10-32 and 41-58 550538004727 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 550538004728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538004729 S-adenosylmethionine binding site [chemical binding]; other site 550538004730 HMMPfam hit to PF08241, Methyltransferase type 11, score 8.2e-23 550538004731 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004732 condesin subunit F; Provisional; Region: PRK05260 550538004733 HMMPfam hit to PF03882, Prokaryotic chromosome segregation and condensation protein MukF, score 0 550538004734 condesin subunit E; Provisional; Region: PRK05256 550538004735 HMMPfam hit to PF04288, Prokaryotic chromosome segregation and condensation protein MukE, score 8.2e-166 550538004736 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 550538004737 P-loop containing region of AAA domain; Region: AAA_29; cl17516 550538004738 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 550538004739 HMMPfam hit to PF04310, Prokaryotic chromosome segregation and condensation protein MukB, N-terminal, score 2.5e-186 550538004740 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004741 murein L,D-transpeptidase; Provisional; Region: PRK10594 550538004742 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 550538004743 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 550538004744 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 550538004745 HMMPfam hit to PF01471, Peptidoglycan binding-like, score 9.7e-10 550538004746 PS00092 N-6 Adenine-specific DNA methylases signature. 550538004747 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538004748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 550538004749 Peptidase M15; Region: Peptidase_M15_3; cl01194 550538004750 1 probable transmembrane helix predicted for SG0938 by TMHMM2.0 at aa 12-34 550538004751 HMMPfam hit to PF05951, Protein of unknown function DUF882, bacterial, score 2.9e-106 550538004752 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 550538004753 HMMPfam hit to PF00753, Beta-lactamase-like, score 3.7e-38 550538004754 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 550538004755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538004756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538004757 homodimer interface [polypeptide binding]; other site 550538004758 catalytic residue [active] 550538004759 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.1e-143 550538004760 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 550538004761 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 550538004762 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 550538004763 trimer interface [polypeptide binding]; other site 550538004764 eyelet of channel; other site 550538004765 HMMPfam hit to PF00267, Porin, Gram-negative type, score 3.9e-198 550538004766 PS00576 General diffusion Gram-negative porins signature. 550538004767 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 550538004768 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 550538004769 putative dimer interface [polypeptide binding]; other site 550538004770 putative anticodon binding site; other site 550538004771 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 550538004772 homodimer interface [polypeptide binding]; other site 550538004773 motif 1; other site 550538004774 motif 2; other site 550538004775 active site 550538004776 motif 3; other site 550538004777 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 3.1e-77 550538004778 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538004779 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538004780 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.1e-19 550538004781 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 550538004782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538004783 putative DNA binding site [nucleotide binding]; other site 550538004784 putative Zn2+ binding site [ion binding]; other site 550538004785 AsnC family; Region: AsnC_trans_reg; pfam01037 550538004786 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 1.8e-18 550538004787 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 8.3e-06 550538004788 PS00519 Bacterial regulatory proteins, asnC family signature. 550538004789 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 550538004790 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 550538004791 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538004792 catalytic residue [active] 550538004793 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 8.6e-09 550538004794 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 550538004795 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 550538004796 11 probable transmembrane helices predicted for SG0945 by TMHMM2.0 at aa 13-35, 76-98, 103-125, 152-174, 189-211, 218-240, 250-272, 314-336, 356-378, 399-418 and 422-439 550538004797 HMMPfam hit to PF01235, Sodium:alanine symporter, score 5e-58 550538004798 PS00873 Sodium:alanine symporter family signature. 550538004799 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 550538004800 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 550538004801 active site 550538004802 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase-like, score 6.1e-125 550538004803 aminopeptidase N; Provisional; Region: pepN; PRK14015 550538004804 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 550538004805 active site 550538004806 Zn binding site [ion binding]; other site 550538004807 HMMPfam hit to PF01433, Peptidase M1, membrane alanine aminopeptidase, N-terminal, score 7.5e-70 550538004808 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538004809 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 550538004810 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 550538004811 quinone interaction residues [chemical binding]; other site 550538004812 active site 550538004813 catalytic residues [active] 550538004814 FMN binding site [chemical binding]; other site 550538004815 substrate binding site [chemical binding]; other site 550538004816 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, core, score 1.1e-104 550538004817 PS00911 Dihydroorotate dehydrogenase signature 1. 550538004818 PS00912 Dihydroorotate dehydrogenase signature 2. 550538004819 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 550538004820 HMMPfam hit to PF07126, Protein of unknown function DUF1379, score 4.2e-121 550538004821 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 550538004822 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 550538004823 MOSC domain; Region: MOSC; pfam03473 550538004824 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 550538004825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 550538004826 catalytic loop [active] 550538004827 iron binding site [ion binding]; other site 550538004828 HMMPfam hit to PF00111, Ferredoxin, score 2e-19 550538004829 HMMPfam hit to PF03473, Molybdenum cofactor sulphurase, C-terminal, score 4.2e-57 550538004830 HMMPfam hit to PF03476, MOSC, N-terminal beta barrel, score 3.6e-46 550538004831 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538004832 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 550538004833 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 550538004834 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 550538004835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538004836 S-adenosylmethionine binding site [chemical binding]; other site 550538004837 HMMPfam hit to PF02926, THUMP, score 1.4e-22 550538004838 HMMPfam hit to PF01170, RNA methylase, score 4.5e-102 550538004839 PS01261 Uncharacterized protein family UPF0020 signature. 550538004840 PS00092 N-6 Adenine-specific DNA methylases signature. 550538004841 HMMPfam hit to PF03602, Conserved hypothetical protein CHP00095, score 0.0034 550538004842 ABC transporter ATPase component; Reviewed; Region: PRK11147 550538004843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538004845 Walker A/P-loop; other site 550538004846 Walker A/P-loop; other site 550538004847 ATP binding site [chemical binding]; other site 550538004848 ATP binding site [chemical binding]; other site 550538004849 Q-loop/lid; other site 550538004850 Q-loop/lid; other site 550538004851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538004852 ABC transporter signature motif; other site 550538004853 Walker B; other site 550538004854 D-loop; other site 550538004855 ABC transporter; Region: ABC_tran_2; pfam12848 550538004856 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538004857 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-45 550538004858 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004859 PS00211 ABC transporters family signature. 550538004860 HMMPfam hit to PF00005, ABC transporter related, score 1.5e-48 550538004861 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004862 PS00211 ABC transporters family signature. 550538004863 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 550538004864 Paraquat-inducible protein A; Region: PqiA; pfam04403 550538004865 Paraquat-inducible protein A; Region: PqiA; pfam04403 550538004866 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 2.5e-88 550538004867 8 probable transmembrane helices predicted for SG0953 by TMHMM2.0 at aa 54-76, 100-122, 135-157, 162-184, 255-277, 304-326, 350-372 and 377-399 550538004868 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.7e-100 550538004869 paraquat-inducible protein B; Provisional; Region: PRK10807 550538004870 mce related protein; Region: MCE; pfam02470 550538004871 mce related protein; Region: MCE; pfam02470 550538004872 mce related protein; Region: MCE; pfam02470 550538004873 1 probable transmembrane helix predicted for SG0954 by TMHMM2.0 at aa 16-38 550538004874 HMMPfam hit to PF02470, Mammalian cell entry related, score 5.9e-22 550538004875 HMMPfam hit to PF02470, Mammalian cell entry related, score 0.0036 550538004876 HMMPfam hit to PF02470, Mammalian cell entry related, score 4.9e-16 550538004877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 550538004878 Protein of unknown function (DUF330); Region: DUF330; pfam03886 550538004879 HMMPfam hit to PF03886, Protein of unknown function DUF330, score 1.8e-90 550538004880 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538004881 ribosome modulation factor; Provisional; Region: PRK14563 550538004882 HMMPfam hit to PF04957, Ribosome modulation factor, score 2.5e-41 550538004883 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 550538004884 active site 1 [active] 550538004885 dimer interface [polypeptide binding]; other site 550538004886 active site 2 [active] 550538004887 HMMPfam hit to PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ, score 1.2e-76 550538004888 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 550538004889 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 550538004890 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 0.00019 550538004891 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 550538004892 HMMPfam hit to PF06303, Protein of unknown function DUF1047, score 1.8e-116 550538004893 outer membrane protein A; Reviewed; Region: PRK10808 550538004894 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 550538004895 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 550538004896 ligand binding site [chemical binding]; other site 550538004897 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 1.7e-47 550538004898 PS01068 OmpA-like domain. 550538004899 HMMPfam hit to PF01389, Outer membrane protein, OmpA-like, transmembrane region, score 4e-121 550538004900 cell division inhibitor SulA; Region: sula; TIGR00623 550538004901 HMMPfam hit to PF03846, Cell division inhibitor SulA, score 8.1e-96 550538004902 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 550538004903 TfoX C-terminal domain; Region: TfoX_C; pfam04994 550538004904 HMMPfam hit to PF04993, TfoX, N-terminal, score 3.4e-07 550538004905 HMMPfam hit to PF04994, TfoX, C-terminal, score 7.5e-34 550538004906 TIGR01666 family membrane protein; Region: YCCS 550538004907 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 550538004908 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 550538004909 HMMPfam hit to PF05976, Protein of unknown function DUF893, YccS/YhfK, score 0 550538004910 7 probable transmembrane helices predicted for SG0963 by TMHMM2.0 at aa 13-35, 86-108, 115-137, 141-163, 438-460, 484-503 and 510-532 550538004911 PS00217 Sugar transport proteins signature 2. 550538004912 Predicted membrane protein [Function unknown]; Region: COG3304 550538004913 Domain of unknown function (DUF307); Region: DUF307; pfam03733 550538004914 Domain of unknown function (DUF307); Region: DUF307; pfam03733 550538004915 HMMPfam hit to PF03733, Protein of unknown function DUF307, score 9e-32 550538004916 3 probable transmembrane helices predicted for SG0964 by TMHMM2.0 at aa 15-37, 77-99 and 104-126 550538004917 HMMPfam hit to PF03733, Protein of unknown function DUF307, score 6e-18 550538004918 DNA helicase IV; Provisional; Region: helD; PRK11054 550538004919 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 550538004920 Part of AAA domain; Region: AAA_19; pfam13245 550538004921 Family description; Region: UvrD_C_2; pfam13538 550538004922 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 1.1e-27 550538004923 PS00017 ATP/GTP-binding site motif A (P-loop). 550538004924 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 3e-18 550538004925 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 550538004926 active site 550538004927 dimer interfaces [polypeptide binding]; other site 550538004928 catalytic residues [active] 550538004929 HMMPfam hit to PF02142, MGS-like, score 7.9e-28 550538004930 PS01335 Methylglyoxal synthase active site. 550538004931 hypothetical protein; Provisional; Region: PRK03641 550538004932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 550538004933 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 550538004934 HMMPfam hit to PF02629, CoA-binding, score 1.2e-23 550538004935 heat shock protein HspQ; Provisional; Region: PRK14129 550538004936 HMMPfam hit to PF08755, Hemimethylated DNA-binding region, score 2.9e-48 550538004937 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 550538004938 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 550538004939 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 550538004940 putative RNA binding site [nucleotide binding]; other site 550538004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538004942 S-adenosylmethionine binding site [chemical binding]; other site 550538004943 PS00294 Prenyl group binding site (CAAX box). 550538004944 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 550538004945 substrate binding site [chemical binding]; other site 550538004946 HMMPfam hit to PF01161, PEBP, score 6.9e-12 550538004947 Cupin domain; Region: Cupin_2; cl17218 550538004948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 550538004949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538004950 PS00041 Bacterial regulatory proteins, araC family signature. 550538004951 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.5e-06 550538004952 acylphosphatase; Provisional; Region: PRK14426 550538004953 HMMPfam hit to PF00708, Acylphosphatase, score 7.8e-17 550538004954 PS00150 Acylphosphatase signature 1. 550538004955 PS00151 Acylphosphatase signature 2. 550538004956 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 550538004957 sulfur transfer protein TusE; Provisional; Region: PRK11508 550538004958 HMMPfam hit to PF04358, DsrC-like protein, score 6.4e-79 550538004959 YccA-like proteins; Region: YccA_like; cd10433 550538004960 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 550538004961 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 1.6e-46 550538004962 6 probable transmembrane helices predicted for SG0975 by TMHMM2.0 at aa 15-37, 49-71, 76-98, 105-127, 132-154 and 167-189 550538004963 PS01243 Uncharacterized protein family UPF0005 signature. 550538004964 Salmonella Pathogenicity Island 5: SPI-5 550538004965 PipA protein; Region: PipA; pfam07108 550538004966 HMMPfam hit to PF07108, PipA, score 3.9e-183 550538004967 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538004968 secreted effector protein PipB; Provisional; Region: PRK15197 550538004969 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 550538004970 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 550538004971 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 550538004972 HMMPfam hit to PF00805, Pentapeptide repeat, score 1.7 550538004973 HMMPfam hit to PF00805, Pentapeptide repeat, score 1.7e-13 550538004974 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 550538004975 HMMPfam hit to PF00805, Pentapeptide repeat, score 1.8e-08 550538004976 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 550538004977 HMMPfam hit to PF07824, Type III secretion system chaperone, score 1.2e-81 550538004978 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 550538004979 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 550538004980 HMMPfam hit to PF05925, Type III secretion system outer membrane, B protein, score 0 550538004981 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 550538004982 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 550538004983 HMMPfam hit to PF03577, Peptidase C69, dipeptidase A, score 3.9e-231 550538004984 1 probable transmembrane helix predicted for SG0983 by TMHMM2.0 at aa 5-27 550538004985 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 550538004986 HAMP domain; Region: HAMP; pfam00672 550538004987 dimerization interface [polypeptide binding]; other site 550538004988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538004989 dimer interface [polypeptide binding]; other site 550538004990 phosphorylation site [posttranslational modification] 550538004991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538004992 ATP binding site [chemical binding]; other site 550538004993 Mg2+ binding site [ion binding]; other site 550538004994 G-X-G motif; other site 550538004995 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.5e-28 550538004996 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.1e-14 550538004997 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3.2e-09 550538004998 2 probable transmembrane helices predicted for SG0984 by TMHMM2.0 at aa 10-32 and 162-181 550538004999 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005000 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 550538005001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538005002 active site 550538005003 phosphorylation site [posttranslational modification] 550538005004 intermolecular recognition site; other site 550538005005 dimerization interface [polypeptide binding]; other site 550538005006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538005007 DNA binding site [nucleotide binding] 550538005008 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.3e-26 550538005009 HMMPfam hit to PF00072, Response regulator receiver, score 2.2e-43 550538005010 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 550538005011 active site 550538005012 homotetramer interface [polypeptide binding]; other site 550538005013 1 probable transmembrane helix predicted for SG0986 by TMHMM2.0 at aa 5-24 550538005014 HMMPfam hit to PF00576, Transthyretin, score 1e-64 550538005015 PS00768 Transthyretin signature 1. 550538005016 PS00769 Transthyretin signature 2. 550538005017 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 550538005018 HMMPfam hit to PF01613, Flavin reductase-like, FMN-binding, score 1.2e-63 550538005019 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 550538005020 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 550538005021 HMMPfam hit to PF03241, 4-hydroxyphenylacetate 3-hydroxylase, score 3.4e-215 550538005022 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 550538005023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 550538005024 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 4.5e-20 550538005025 PS01117 Bacterial regulatory proteins, marR family signature. 550538005026 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 550538005027 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 550538005028 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 550538005029 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 1.9e-11 550538005030 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 2.4e-86 550538005031 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 550538005032 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 550538005033 NAD binding site [chemical binding]; other site 550538005034 catalytic residues [active] 550538005035 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 5.2e-238 550538005036 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538005037 PS00070 Aldehyde dehydrogenases cysteine active site. 550538005038 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 550538005039 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 550538005040 putative active site [active] 550538005041 putative metal binding site [ion binding]; other site 550538005042 HMMPfam hit to PF02900, Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B, score 1.4e-87 550538005043 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 550538005044 putative substrate binding pocket [chemical binding]; other site 550538005045 trimer interface [polypeptide binding]; other site 550538005046 HMMPfam hit to PF02962, 5-carboxymethyl-2-hydroxymuconate isomerase, score 1.1e-99 550538005047 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 550538005048 HMMPfam hit to PF01689, Hydratase/decarboxylase, score 3e-139 550538005049 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 550538005050 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 5.8e-114 550538005051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538005052 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 550538005053 putative substrate translocation pore; other site 550538005054 12 probable transmembrane helices predicted for SG0996 by TMHMM2.0 at aa 32-54, 69-88, 101-123, 133-155, 162-184, 194-216, 270-292, 305-327, 340-357, 361-383, 396-418 and 428-447 550538005055 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.7e-56 550538005056 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 550538005057 Cupin domain; Region: Cupin_2; cl17218 550538005058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538005059 PS00041 Bacterial regulatory proteins, araC family signature. 550538005060 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.6e-08 550538005061 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 550538005062 HMMPfam hit to PF00753, Beta-lactamase-like, score 2.4e-10 550538005063 anti-adapter protein IraM; Provisional; Region: PRK09919 550538005064 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 550538005065 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 550538005066 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 550538005067 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 550538005068 HSP70 interaction site [polypeptide binding]; other site 550538005069 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 550538005070 substrate binding site [polypeptide binding]; other site 550538005071 dimer interface [polypeptide binding]; other site 550538005072 HMMPfam hit to PF01556, Chaperone DnaJ, C-terminal, score 1.2e-32 550538005073 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 3e-34 550538005074 PS00636 Nt-dnaJ domain signature. 550538005075 2 probable transmembrane helices predicted for SG1002 by TMHMM2.0 at aa 7-29 and 66-88 550538005076 PS00435 Peroxidases proximal heme-ligand signature. 550538005077 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 550538005078 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 550538005079 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 550538005080 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 550538005081 DsbD alpha interface [polypeptide binding]; other site 550538005082 catalytic residues [active] 550538005083 6 probable transmembrane helices predicted for SG1003 by TMHMM2.0 at aa 280-302, 323-345, 360-382, 409-431, 436-458 and 479-501 550538005084 HMMPfam hit to PF02683, Cytochrome c biogenesis protein, transmembrane region, score 0.00017 550538005085 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 550538005086 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 550538005087 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 550538005088 catalytic residues [active] 550538005089 HMMPfam hit to PF01323, DSBA oxidoreductase, score 2e-44 550538005090 PS00194 Thioredoxin family active site. 550538005091 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 550538005092 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 550538005093 catalytic residues [active] 550538005094 1 probable transmembrane helix predicted for SG1005 by TMHMM2.0 at aa 12-29 550538005095 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 1.7e-12 550538005096 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 550538005097 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 550538005098 catalytic core [active] 550538005099 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 550538005100 HMMPfam hit to PF00328, Histidine acid phosphatase, score 7.4e-63 550538005101 PS00616 Histidine acid phosphatases phosphohistidine signature. 550538005102 PS00778 Histidine acid phosphatases active site signature. 550538005103 hypothetical protein; Provisional; Region: PRK10174 550538005104 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 550538005105 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 550538005106 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 9.7e-25 550538005107 General stress protein [General function prediction only]; Region: GsiB; COG3729 550538005108 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005109 note that in comparison to S. enteritidis PT4 this CDS has suffered a deletion event removing the first 82 codons 550538005110 HMMPfam hit to PF08362, Transcriptional regulator, YcdC, C-terminal, score 4.6e-74 550538005111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 550538005112 HMMPfam hit to PF07007, Protein of unknown function DUF1311, score 1.3e-47 550538005113 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 550538005114 Predicted transcriptional regulator [Transcription]; Region: COG3905 550538005115 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 550538005116 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 550538005117 Glutamate binding site [chemical binding]; other site 550538005118 NAD binding site [chemical binding]; other site 550538005119 catalytic residues [active] 550538005120 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 3.3e-103 550538005121 PS00070 Aldehyde dehydrogenases cysteine active site. 550538005122 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538005123 HMMPfam hit to PF01619, Proline dehydrogenase, score 3.4e-193 550538005124 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 550538005125 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 550538005126 Na binding site [ion binding]; other site 550538005127 12 probable transmembrane helices predicted for SG1013 by TMHMM2.0 at aa 7-26, 66-88, 125-147, 162-184, 191-213, 233-255, 276-298, 313-335, 372-391, 401-423, 428-450 and 455-473 550538005128 HMMPfam hit to PF00474, Na+/solute symporter, score 1.5e-215 550538005129 PS00456 Sodium:solute symporter family signature 1. 550538005130 PS00457 Sodium:solute symporter family signature 2. 550538005131 hypothetical protein; Provisional; Region: PRK10536 550538005132 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 550538005133 HMMPfam hit to PF02562, PhoH-like protein, score 3.4e-140 550538005134 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005135 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 550538005136 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 550538005137 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 550538005138 putative active site [active] 550538005139 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 8.5e-22 550538005140 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 2.9e-30 550538005141 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 550538005142 Na binding site [ion binding]; other site 550538005143 13 probable transmembrane helices predicted for SG1016 by TMHMM2.0 at aa 6-28, 41-63, 78-100, 121-143, 158-180, 187-209, 229-248, 280-299, 314-336, 376-398, 403-425, 432-454 and 458-480 550538005144 HMMPfam hit to PF00474, Na+/solute symporter, score 1.4e-09 550538005145 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 550538005146 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 550538005147 putative active site cavity [active] 550538005148 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epimerase, score 4.9e-121 550538005149 note the frame shift mutation following codon 107 550538005150 HMMPfam hit to PF01344, Kelch repeat type 1, score 2.8e-09 550538005151 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 550538005152 HMMPfam hit to PF06178, Oligogalacturonate-specific porin, score 5.1e-125 550538005153 putative sialic acid transporter; Provisional; Region: PRK12307 550538005154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538005155 putative substrate translocation pore; other site 550538005156 12 probable transmembrane helices predicted for SG1021 by TMHMM2.0 at aa 20-42, 57-76, 88-110, 114-136, 143-165, 169-188, 230-252, 267-286, 299-316, 321-343, 360-382 and 387-409 550538005157 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.2e-41 550538005158 the sequence has been checked and is believed to be correct 550538005159 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.2e-40 550538005160 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 2.1e-18 550538005161 YCII-related domain; Region: YCII; cl00999 550538005162 HMMPfam hit to PF03795, YCII-related, score 6.5e-20 550538005164 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 550538005165 1 probable transmembrane helix predicted for SG1025 by TMHMM2.0 at aa 4-26 550538005166 1 probable transmembrane helix predicted for SG1026 by TMHMM2.0 at aa 5-23 550538005167 note the frame shift mutation following codon 4 550538005168 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538005169 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 0.00082 550538005170 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 550538005171 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 3e-58 550538005172 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 550538005173 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 550538005174 ImpA domain protein; Region: DUF3702; pfam12486 550538005175 1 probable transmembrane helix predicted for SG1030 by TMHMM2.0 at aa 319-338 550538005176 HMMPfam hit to PF06812, ImpA, N-terminal, score 1.1e-24 550538005177 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 550538005178 AAA ATPase domain; Region: AAA_16; pfam13191 550538005179 AAA domain; Region: AAA_17; pfam13207 550538005180 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 550538005181 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 550538005182 PS00120 Lipases, serine active site. 550538005183 HMMPfam hit to PF06744, Protein of unknown function DUF1215, score 4e-51 550538005184 HMMPfam hit to PF06761, ImcF-related, score 4.4e-127 550538005185 3 probable transmembrane helices predicted for SG1031 by TMHMM2.0 at aa 26-45, 65-84 and 449-471 550538005186 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005187 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 550538005188 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 550538005189 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 550538005190 HMMPfam hit to PF06812, ImpA, N-terminal, score 5.8e-07 550538005191 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 550538005192 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 550538005193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538005194 Walker A motif; other site 550538005195 ATP binding site [chemical binding]; other site 550538005196 Walker B motif; other site 550538005197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538005198 Walker A motif; other site 550538005199 ATP binding site [chemical binding]; other site 550538005200 Walker B motif; other site 550538005201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 550538005202 HMMPfam hit to PF07724, ATPase AAA-2, score 4.1e-82 550538005203 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005204 PS00870 Chaperonins clpA/B signature 1. 550538005205 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005206 HMMPfam hit to PF02861, Clp, N-terminal, score 0.00042 550538005207 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 550538005208 1 probable transmembrane helix predicted for SG1035 by TMHMM2.0 at aa 211-233 550538005209 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 550538005210 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 550538005211 HMMPfam hit to PF05936, Protein of unknown function DUF876, bacterial, score 1.1e-246 550538005212 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 550538005213 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005214 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 550538005215 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 550538005216 HMMPfam hit to PF06996, Protein of unknown function DUF1305, score 1.2e-134 550538005217 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 550538005218 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 550538005219 HMMPfam hit to PF05947, Protein of unknown function DUF879, bacterial, score 1.1e-266 550538005220 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 550538005221 Protein of unknown function (DUF877); Region: DUF877; pfam05943 550538005222 HMMPfam hit to PF05943, Protein of unknown function DUF877, score 2.4e-298 550538005223 Protein of unknown function (DUF770); Region: DUF770; pfam05591 550538005224 HMMPfam hit to PF05591, Uncharacterised conserved protein UCP028301, score 2.2e-75 550538005225 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 550538005226 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 2.5e-84 550538005227 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 550538005228 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 550538005229 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 550538005230 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 550538005231 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005232 HMMPfam hit to PF04524, Rhs element Vgr protein, score 3.1e-54 550538005233 PAAR motif; Region: PAAR_motif; cl15808 550538005234 RHS Repeat; Region: RHS_repeat; pfam05593 550538005235 RHS Repeat; Region: RHS_repeat; cl11982 550538005236 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 550538005237 RHS Repeat; Region: RHS_repeat; pfam05593 550538005238 RHS Repeat; Region: RHS_repeat; pfam05593 550538005239 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 550538005240 HMMPfam hit to PF05593, YD repeat, score 0.012 550538005241 HMMPfam hit to PF05593, YD repeat, score 0.16 550538005242 HMMPfam hit to PF05593, YD repeat, score 0.022 550538005243 HMMPfam hit to PF05593, YD repeat, score 2.4e-05 550538005244 HMMPfam hit to PF05593, YD repeat, score 0.1 550538005245 HMMPfam hit to PF05593, YD repeat, score 4.6e-07 550538005246 HMMPfam hit to PF05593, YD repeat, score 9.2e-08 550538005247 HMMPfam hit to PF05593, YD repeat, score 0.00023 550538005248 HMMPfam hit to PF05593, YD repeat, score 0.00014 550538005249 HMMPfam hit to PF05593, YD repeat, score 0.0041 550538005250 HMMPfam hit to PF05593, YD repeat, score 1.1 550538005251 the sequence has been checked and is believed to be correct 550538005252 HMMPfam hit to PF03527, RHS protein, score 1.6e-17 550538005253 PAAR motif; Region: PAAR_motif; cl15808 550538005254 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 550538005255 RHS Repeat; Region: RHS_repeat; pfam05593 550538005256 RHS Repeat; Region: RHS_repeat; pfam05593 550538005257 RHS Repeat; Region: RHS_repeat; pfam05593 550538005258 RHS Repeat; Region: RHS_repeat; cl11982 550538005259 RHS Repeat; Region: RHS_repeat; pfam05593 550538005260 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 550538005261 RHS Repeat; Region: RHS_repeat; pfam05593 550538005262 RHS Repeat; Region: RHS_repeat; pfam05593 550538005263 RHS Repeat; Region: RHS_repeat; cl11982 550538005264 RHS protein; Region: RHS; pfam03527 550538005265 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 550538005266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005267 HMMPfam hit to PF05593, YD repeat, score 1.5 550538005268 HMMPfam hit to PF05593, YD repeat, score 0.15 550538005269 HMMPfam hit to PF05593, YD repeat, score 0.0023 550538005270 HMMPfam hit to PF05593, YD repeat, score 6.4e-06 550538005271 HMMPfam hit to PF05593, YD repeat, score 0.045 550538005272 HMMPfam hit to PF05593, YD repeat, score 9.4e-06 550538005273 HMMPfam hit to PF05593, YD repeat, score 4.6e-05 550538005274 HMMPfam hit to PF05593, YD repeat, score 0.00023 550538005275 HMMPfam hit to PF05593, YD repeat, score 0.0015 550538005276 HMMPfam hit to PF05593, YD repeat, score 1.7e-05 550538005277 HMMPfam hit to PF05593, YD repeat, score 2.2 550538005278 HMMPfam hit to PF03527, RHS protein, score 6.9e-18 550538005279 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538005280 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 550538005281 1 probable transmembrane helix predicted for SG1049 by TMHMM2.0 at aa 86-108 550538005282 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538005283 Sel1-like repeats; Region: SEL1; smart00671 550538005284 Sel1-like repeats; Region: SEL1; smart00671 550538005285 1 probable transmembrane helix predicted for SG1050 by TMHMM2.0 at aa 5-24 550538005286 HMMPfam hit to PF08238, Sel1-like, score 1.4e-08 550538005287 HMMPfam hit to PF08238, Sel1-like, score 5.6e-10 550538005288 note the premature stop codon following codon 86 550538005289 HMMPfam hit to PF08238, Sel1-like, score 0.002 550538005290 HMMPfam hit to PF08238, Sel1-like, score 0.0046 550538005291 Transposase; Region: HTH_Tnp_1; cl17663 550538005292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 550538005293 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.6e-10 550538005294 note the frame shift mutation following codon 142 550538005295 HMMPfam hit to PF00665, Integrase, catalytic core, score 4.8e-49 550538005296 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005297 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 550538005298 DNA-binding site [nucleotide binding]; DNA binding site 550538005299 RNA-binding motif; other site 550538005300 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 1.5e-42 550538005301 PS00352 'Cold-shock' DNA-binding domain signature. 550538005302 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 550538005303 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 550538005304 trimer interface [polypeptide binding]; other site 550538005305 eyelet of channel; other site 550538005306 HMMPfam hit to PF00267, Porin, Gram-negative type, score 4e-214 550538005307 PS00576 General diffusion Gram-negative porins signature. 550538005308 2 probable transmembrane helices predicted for SG1061 by TMHMM2.0 at aa 19-41 and 61-80 550538005309 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 550538005310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 550538005311 Zn2+ binding site [ion binding]; other site 550538005312 Mg2+ binding site [ion binding]; other site 550538005313 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 9.4e-12 550538005314 DNA cytosine methylase; Provisional; Region: PRK10458 550538005315 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 550538005316 cofactor binding site; other site 550538005317 DNA binding site [nucleotide binding] 550538005318 substrate interaction site [chemical binding]; other site 550538005319 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 5.9e-83 550538005320 PS00094 C-5 cytosine-specific DNA methylases active site. 550538005321 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 550538005322 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 550538005323 additional DNA contacts [nucleotide binding]; other site 550538005324 mismatch recognition site; other site 550538005325 active site 550538005326 zinc binding site [ion binding]; other site 550538005327 DNA intercalation site [nucleotide binding]; other site 550538005328 HMMPfam hit to PF03852, DNA mismatch endonuclease vsr, score 8.1e-39 550538005330 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 9.3e-17 550538005331 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.9e-28 550538005332 hypothetical protein; Provisional; Region: PRK10062 550538005333 HMMPfam hit to PF05661, Protein of unknown function DUF808, score 4.6e-184 550538005334 5 probable transmembrane helices predicted for SG1067 by TMHMM2.0 at aa 78-100, 150-169, 173-195, 230-252 and 267-289 550538005335 Uncharacterized small protein [Function unknown]; Region: COG5475 550538005336 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 550538005337 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538005338 metal binding site [ion binding]; metal-binding site 550538005339 active site 550538005340 I-site; other site 550538005341 2 probable transmembrane helices predicted for SG1069 by TMHMM2.0 at aa 20-42 and 358-380 550538005342 HMMPfam hit to PF00990, GGDEF, score 1.2e-66 550538005343 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 550538005344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538005345 active site 550538005346 motif I; other site 550538005347 motif II; other site 550538005348 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.1e-09 550538005349 PS01228 Hypothetical cof family signature 1. 550538005350 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 550538005351 hypothetical protein; Provisional; Region: PRK10708 550538005352 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 550538005353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538005354 DNA binding residues [nucleotide binding] 550538005355 dimerization interface [polypeptide binding]; other site 550538005356 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1e-21 550538005357 PS00622 Bacterial regulatory proteins, luxR family signature. 550538005358 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 550538005359 HMMPfam hit to PF01311, Type III secretion system inner membrane R protein, score 1.8e-95 550538005360 6 probable transmembrane helices predicted for SG1074 by TMHMM2.0 at aa 15-34, 41-58, 73-95, 132-154, 179-201 and 214-236 550538005361 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 550538005362 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 7.2e-43 550538005363 2 probable transmembrane helices predicted for SG1075 by TMHMM2.0 at aa 20-42 and 52-74 550538005364 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 550538005365 HMMPfam hit to PF00813, Type III secretion system inner membrane P protein, score 3.3e-125 550538005366 5 probable transmembrane helices predicted for SG1076 by TMHMM2.0 at aa 5-27, 47-69, 88-105, 185-207 and 214-236 550538005367 PS01061 Flagella transport protein fliP family signature 2. 550538005368 PS01060 Flagella transport protein fliP family signature 1. 550538005369 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 550538005370 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 2.4e-46 550538005371 1 probable transmembrane helix predicted for SG1077 by TMHMM2.0 at aa 18-40 550538005372 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 550538005373 flagellar motor switch protein; Validated; Region: fliN; PRK05698 550538005374 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 2.8e-36 550538005375 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 550538005376 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 550538005377 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 3.3e-124 550538005378 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 550538005379 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 7.5e-53 550538005380 1 probable transmembrane helix predicted for SG1080 by TMHMM2.0 at aa 33-55 550538005381 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005382 flagellar hook-length control protein; Provisional; Region: PRK10118 550538005383 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 550538005384 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 1.1e-52 550538005385 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005386 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 550538005387 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 550538005388 HMMPfam hit to PF02050, Flagellar FliJ protein, score 7.6e-122 550538005389 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 550538005390 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 550538005391 Walker A motif/ATP binding site; other site 550538005392 Walker B motif; other site 550538005393 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 1.3e-122 550538005394 PS00152 ATP synthase alpha and beta subunits signature. 550538005395 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005396 flagellar assembly protein H; Validated; Region: fliH; PRK05687 550538005397 Flagellar assembly protein FliH; Region: FliH; pfam02108 550538005398 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 3.1e-126 550538005399 flagellar motor switch protein FliG; Region: fliG; TIGR00207 550538005400 FliG C-terminal domain; Region: FliG_C; pfam01706 550538005401 HMMPfam hit to PF01706, Flagellar motor switch protein FliG, score 1.9e-62 550538005402 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 550538005403 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 550538005404 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 550538005405 HMMPfam hit to PF08345, Flagellar M-ring C-terminal, score 5.3e-87 550538005406 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 1e-89 550538005407 1 probable transmembrane helix predicted for SG1086 by TMHMM2.0 at aa 26-45 550538005408 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 550538005409 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein FliE, score 2.1e-48 550538005410 1 probable transmembrane helix predicted for SG1088 by TMHMM2.0 at aa 12-34 550538005411 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 550538005412 CPxP motif; other site 550538005413 HMMPfam hit to PF01206, SirA-like, score 5.2e-43 550538005414 PS01148 Uncharacterized protein family UPF0033 signature. 550538005415 putative inner membrane protein; Provisional; Region: PRK11099 550538005416 Sulphur transport; Region: Sulf_transp; pfam04143 550538005417 10 probable transmembrane helices predicted for SG1090 by TMHMM2.0 at aa 30-52, 97-119, 132-151, 166-188, 217-234, 244-266, 279-301, 306-328, 341-360 and 380-402 550538005418 HMMPfam hit to PF04143, Protein of unknown function DUF395, YeeE/YedE, score 3.6e-22 550538005419 HMMPfam hit to PF04143, Protein of unknown function DUF395, YeeE/YedE, score 5.6e-19 550538005420 lipoprotein; Provisional; Region: PRK10397 550538005421 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005422 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 550538005423 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 550538005424 active site 550538005425 Na/Ca binding site [ion binding]; other site 550538005426 catalytic site [active] 550538005427 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 0.00072 550538005428 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 8.7e-91 550538005429 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 550538005430 HMMPfam hit to PF05400, Flagellar export chaperone, score 7.7e-80 550538005431 flagellar protein FliS; Validated; Region: fliS; PRK05685 550538005432 HMMPfam hit to PF02561, Flagellar protein FliS, score 1.2e-52 550538005433 flagellar capping protein; Reviewed; Region: fliD; PRK08032 550538005434 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 550538005435 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 550538005436 HMMPfam hit to PF07195, Flagellar hook-associated 2, C-terminal, score 5.6e-80 550538005437 HMMPfam hit to PF07196, Flagellin hook IN, score 5.4e-11 550538005438 HMMPfam hit to PF02465, Flagellar hook-associated protein 2, N-terminal, score 1.3e-30 550538005439 flagellin; Validated; Region: PRK08026 550538005440 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 550538005441 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 550538005442 HMMPfam hit to PF00669, Flagellin, N-terminal, score 4.1e-81 550538005443 HMMPfam hit to PF00700, Flagellin, C-terminal, score 8.4e-40 550538005444 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 550538005445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 550538005446 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 550538005447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 550538005448 DNA binding residues [nucleotide binding] 550538005449 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 5.2e-19 550538005450 PS00715 Sigma-70 factors family signature 1. 550538005451 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 1.2e-21 550538005452 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 5.6e-20 550538005453 PS00716 Sigma-70 factors family signature 2. 550538005454 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 550538005455 PS00190 Cytochrome c family heme-binding site signature. 550538005456 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 4.8e-17 550538005457 cystine transporter subunit; Provisional; Region: PRK11260 550538005458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538005459 substrate binding pocket [chemical binding]; other site 550538005460 membrane-bound complex binding site; other site 550538005461 hinge residues; other site 550538005462 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 2.1e-104 550538005463 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 550538005464 D-cysteine desulfhydrase; Validated; Region: PRK03910 550538005465 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 550538005466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538005467 catalytic residue [active] 550538005468 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1.6e-08 550538005469 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538005470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538005471 dimer interface [polypeptide binding]; other site 550538005472 conserved gate region; other site 550538005473 putative PBP binding loops; other site 550538005474 ABC-ATPase subunit interface; other site 550538005475 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.5e-35 550538005476 3 probable transmembrane helices predicted for SG1102 by TMHMM2.0 at aa 20-42, 54-76 and 185-207 550538005477 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538005478 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 550538005479 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 550538005480 Walker A/P-loop; other site 550538005481 ATP binding site [chemical binding]; other site 550538005482 Q-loop/lid; other site 550538005483 ABC transporter signature motif; other site 550538005484 Walker B; other site 550538005485 D-loop; other site 550538005486 H-loop/switch region; other site 550538005487 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 550538005488 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-72 550538005489 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005490 PS00211 ABC transporters family signature. 550538005491 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 1.3e-05 550538005492 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 550538005493 Autoinducer binding domain; Region: Autoind_bind; pfam03472 550538005494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538005495 DNA binding residues [nucleotide binding] 550538005496 dimerization interface [polypeptide binding]; other site 550538005497 HMMPfam hit to PF03472, Autoinducer-binding, score 2.3e-52 550538005498 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.4e-24 550538005499 PS00622 Bacterial regulatory proteins, luxR family signature. 550538005500 hypothetical protein; Provisional; Region: PRK10613 550538005501 response regulator; Provisional; Region: PRK09483 550538005502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538005503 active site 550538005504 phosphorylation site [posttranslational modification] 550538005505 intermolecular recognition site; other site 550538005506 dimerization interface [polypeptide binding]; other site 550538005507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538005508 DNA binding residues [nucleotide binding] 550538005509 dimerization interface [polypeptide binding]; other site 550538005510 HMMPfam hit to PF00072, Response regulator receiver, score 3.4e-45 550538005511 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 5.3e-27 550538005512 PS00622 Bacterial regulatory proteins, luxR family signature. 550538005513 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 550538005514 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 550538005515 GIY-YIG motif/motif A; other site 550538005516 active site 550538005517 catalytic site [active] 550538005518 putative DNA binding site [nucleotide binding]; other site 550538005519 metal binding site [ion binding]; metal-binding site 550538005520 UvrB/uvrC motif; Region: UVR; pfam02151 550538005521 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 550538005522 Helix-hairpin-helix motif; Region: HHH; pfam00633 550538005523 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 1.2e-32 550538005524 HMMPfam hit to PF02151, UvrB/UvrC protein, score 8.7e-12 550538005525 HMMPfam hit to PF08459, Excinuclease ABC, C subunit, C-terminal, score 5.6e-90 550538005526 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 5.8e-07 550538005527 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 4.9e-07 550538005528 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 550538005529 4 probable transmembrane helices predicted for SG1108 by TMHMM2.0 at aa 7-29, 33-52, 121-143 and 147-169 550538005530 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 3.9e-48 550538005531 PS00379 CDP-alcohol phosphatidyltransferases signature. 550538005532 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 550538005533 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 550538005534 NlpC/P60 family; Region: NLPC_P60; cl17555 550538005535 HMMPfam hit to PF00877, NLP/P60, score 0.00012 550538005537 hypothetical protein; Provisional; Region: PRK10396 550538005538 yecA family protein; Region: ygfB_yecA; TIGR02292 550538005539 SEC-C motif; Region: SEC-C; pfam02810 550538005540 HMMPfam hit to PF02810, SEC-C motif, score 7.8e-07 550538005541 PS00294 Prenyl group binding site (CAAX box). 550538005542 tyrosine transporter TyrP; Provisional; Region: PRK15132 550538005543 aromatic amino acid transport protein; Region: araaP; TIGR00837 550538005544 11 probable transmembrane helices predicted for SG1116 by TMHMM2.0 at aa 7-29, 33-55, 81-103, 113-135, 148-167, 182-204, 216-235, 277-299, 312-334, 338-360 and 380-402 550538005545 HMMPfam hit to PF03222, Aromatic amino acid permease, score 1.8e-196 550538005546 PS00594 Aromatic amino acids permeases signature. 550538005547 probable metal-binding protein; Region: matur_matur; TIGR03853 550538005548 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 550538005549 Ferritin-like domain; Region: Ferritin; pfam00210 550538005550 ferroxidase diiron center [ion binding]; other site 550538005551 HMMPfam hit to PF00210, Ferritin and Dps, score 7.1e-44 550538005552 YecR-like lipoprotein; Region: YecR; pfam13992 550538005553 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005554 hypothetical protein; Provisional; Region: PRK09273 550538005555 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 550538005556 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 550538005557 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 1.6e-36 550538005558 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 550538005559 Ferritin-like domain; Region: Ferritin; pfam00210 550538005560 ferroxidase diiron center [ion binding]; other site 550538005561 HMMPfam hit to PF00210, Ferritin and Dps, score 4.6e-21 550538005562 DJ-1 family protein; Region: not_thiJ; TIGR01383 550538005563 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 550538005564 conserved cys residue [active] 550538005565 HMMPfam hit to PF01965, ThiJ/PfpI, score 3.1e-22 550538005566 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 550538005567 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 550538005568 HMMPfam hit to PF02358, Trehalose-phosphatase, score 5.2e-73 550538005569 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 550538005570 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 550538005571 active site 550538005572 homotetramer interface [polypeptide binding]; other site 550538005573 HMMPfam hit to PF00982, Glycosyl transferase, family 20, score 1e-207 550538005574 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 550538005575 Ligand Binding Site [chemical binding]; other site 550538005576 HMMPfam hit to PF00582, UspA, score 4.2e-11 550538005577 transcriptional activator FlhD; Provisional; Region: PRK02909 550538005578 HMMPfam hit to PF05247, Flagellar transcriptional activator, score 9.3e-78 550538005579 transcriptional activator FlhC; Provisional; Region: PRK12722 550538005580 HMMPfam hit to PF05280, Flagellar transcriptional activator FlhC, score 1.9e-159 550538005581 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 550538005582 flagellar motor protein MotA; Validated; Region: PRK09110 550538005583 3 probable transmembrane helices predicted for SG1128 by TMHMM2.0 at aa 10-32, 152-171 and 186-208 550538005584 PS01307 Flagellar motor protein motA family signature. 550538005585 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 550538005586 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 550538005587 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 550538005588 ligand binding site [chemical binding]; other site 550538005589 1 probable transmembrane helix predicted for SG1129 by TMHMM2.0 at aa 29-51 550538005590 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 3.1e-36 550538005591 chemotaxis protein CheA; Provisional; Region: PRK10547 550538005592 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 550538005593 putative binding surface; other site 550538005594 active site 550538005595 CheY binding; Region: CheY-binding; pfam09078 550538005596 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 550538005597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538005598 ATP binding site [chemical binding]; other site 550538005599 Mg2+ binding site [ion binding]; other site 550538005600 G-X-G motif; other site 550538005601 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 550538005602 HMMPfam hit to PF01627, Hpt, score 2.6e-16 550538005603 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 550538005604 HMMPfam hit to PF09078, CheY binding, score 2.6e-30 550538005605 HMMPfam hit to PF02895, Signal transducing histidine kinase, homodimeric, score 7.1e-29 550538005606 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.6e-29 550538005607 HMMPfam hit to PF01584, CheW-like protein, score 3.8e-28 550538005608 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 550538005609 putative CheA interaction surface; other site 550538005610 HMMPfam hit to PF01584, CheW-like protein, score 4.1e-34 550538005612 HMMPfam hit to PF02203, Ligand binding Tar, score 5.3e-53 550538005613 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 5.5e-19 550538005614 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.4e-120 550538005615 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 550538005616 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 550538005617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538005618 S-adenosylmethionine binding site [chemical binding]; other site 550538005619 HMMPfam hit to PF03705, MCP methyltransferase, CheR-type, score 6.2e-17 550538005620 HMMPfam hit to PF01739, MCP methyltransferase, CheR-type, score 9e-91 550538005621 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 550538005622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538005623 active site 550538005624 phosphorylation site [posttranslational modification] 550538005625 intermolecular recognition site; other site 550538005626 dimerization interface [polypeptide binding]; other site 550538005627 CheB methylesterase; Region: CheB_methylest; pfam01339 550538005628 HMMPfam hit to PF00072, Response regulator receiver, score 2.7e-33 550538005629 HMMPfam hit to PF01339, Chemotaxis response regulator protein-glutamate methylesterase, score 2.3e-132 550538005630 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 550538005631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538005632 active site 550538005633 phosphorylation site [posttranslational modification] 550538005634 intermolecular recognition site; other site 550538005635 dimerization interface [polypeptide binding]; other site 550538005636 HMMPfam hit to PF00072, Response regulator receiver, score 9.7e-48 550538005637 chemotaxis regulator CheZ; Provisional; Region: PRK11166 550538005638 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 5e-150 550538005640 HMMPfam hit to PF01312, Type III secretion exporter, score 9e-112 550538005641 the sequence has been checked and is believed to be correct 550538005642 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 0 550538005643 Flagellar protein FlhE; Region: FlhE; pfam06366 550538005644 HMMPfam hit to PF06366, Flagellar FlhE, score 2.5e-91 550538005645 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 550538005646 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 1.3e-166 550538005647 penicillin-binding protein 2; Provisional; Region: PRK10795 550538005648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 550538005649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 550538005650 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 4.4e-78 550538005651 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 2.1e-60 550538005652 1 probable transmembrane helix predicted for SG1142 by TMHMM2.0 at aa 12-34 550538005653 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 550538005654 arginyl-tRNA synthetase; Region: argS; TIGR00456 550538005655 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 550538005656 active site 550538005657 HIGH motif; other site 550538005658 KMSK motif region; other site 550538005659 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 550538005660 tRNA binding surface [nucleotide binding]; other site 550538005661 anticodon binding site; other site 550538005662 HMMPfam hit to PF05746, DALR anticodon binding, score 1.7e-52 550538005663 HMMPfam hit to PF00750, Arginyl-tRNA synthetase, class Ic, core, score 2.6e-212 550538005664 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538005665 HMMPfam hit to PF03485, Arginyl tRNA synthetase, class Ic, N-terminal, score 2.5e-31 550538005666 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 550538005667 putative metal binding site [ion binding]; other site 550538005668 PS00414 Profilin signature. 550538005669 HMMPfam hit to PF06185, Protein of unknown function DUF991, score 3.2e-111 550538005670 copper homeostasis protein CutC; Provisional; Region: PRK11572 550538005671 HMMPfam hit to PF03932, CutC, score 9.5e-119 550538005672 Methyltransferase domain; Region: Methyltransf_23; pfam13489 550538005673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538005674 S-adenosylmethionine binding site [chemical binding]; other site 550538005675 HMMPfam hit to PF08003, Methyltransferase, , score 3.9e-249 550538005676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538005677 S-adenosylmethionine binding site [chemical binding]; other site 550538005678 HMMPfam hit to PF08242, Methyltransferase type 12, score 6e-11 550538005679 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 550538005680 4 probable transmembrane helices predicted for SG1148 by TMHMM2.0 at aa 4-22, 43-62, 72-89 and 102-124 550538005681 hypothetical protein; Provisional; Region: PRK10302 550538005682 HMMPfam hit to PF01904, Protein of unknown function DUF72, score 1.1e-81 550538005683 Isochorismatase family; Region: Isochorismatase; pfam00857 550538005684 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 550538005685 catalytic triad [active] 550538005686 conserved cis-peptide bond; other site 550538005687 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 7.3e-75 550538005688 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 550538005689 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 550538005690 dimer interface [polypeptide binding]; other site 550538005691 anticodon binding site; other site 550538005692 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 550538005693 homodimer interface [polypeptide binding]; other site 550538005694 motif 1; other site 550538005695 active site 550538005696 motif 2; other site 550538005697 GAD domain; Region: GAD; pfam02938 550538005698 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 550538005699 active site 550538005700 motif 3; other site 550538005701 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 2.3e-27 550538005702 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 2.6e-215 550538005703 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538005704 HMMPfam hit to PF02938, GAD, score 1.3e-52 550538005705 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538005706 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 550538005707 nudix motif; other site 550538005708 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 9.2e-30 550538005709 PS00893 mutT domain signature. 550538005710 hypothetical protein; Validated; Region: PRK00110 550538005711 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 7.9e-151 550538005712 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 550538005713 active site 550538005714 putative DNA-binding cleft [nucleotide binding]; other site 550538005715 dimer interface [polypeptide binding]; other site 550538005716 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease RuvC, score 6e-104 550538005717 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 550538005718 hypothetical protein; Provisional; Region: PRK11470 550538005719 HMMPfam hit to PF06520, Protein of unknown function DUF1105, score 1e-137 550538005720 4 probable transmembrane helices predicted for SG1156 by TMHMM2.0 at aa 9-28, 43-62, 69-88 and 115-137 550538005721 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 550538005722 RuvA N terminal domain; Region: RuvA_N; pfam01330 550538005723 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 550538005724 HMMPfam hit to PF01330, DNA helicase, Holliday junction RuvA type, domain I, bacterial, score 4.3e-29 550538005725 HMMPfam hit to PF07499, DNA helicase, Holliday junction RuvA type, C-terminal domain III, score 1.7e-16 550538005726 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 550538005727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538005728 Walker A motif; other site 550538005729 ATP binding site [chemical binding]; other site 550538005730 Walker B motif; other site 550538005731 arginine finger; other site 550538005732 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 550538005733 HMMPfam hit to PF05496, DNA helicase, Holliday junction RuvB type, N-terminal, score 1e-07 550538005734 HMMPfam hit to PF00004, AAA ATPase, core, score 1.1e-35 550538005735 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005736 HMMPfam hit to PF05491, DNA helicase, Holliday junction RuvB type, C-terminal, score 3.9e-55 550538005737 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 550538005738 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538005739 ABC-ATPase subunit interface; other site 550538005740 dimer interface [polypeptide binding]; other site 550538005741 putative PBP binding regions; other site 550538005742 HMMPfam hit to PF00950, ABC-3, score 1.3e-124 550538005743 7 probable transmembrane helices predicted for SG1159 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145, 170-192, 213-235 and 239-256 550538005744 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005745 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 550538005746 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 550538005747 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-47 550538005748 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005749 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 550538005750 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 550538005751 metal binding site [ion binding]; metal-binding site 550538005752 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 1.8e-33 550538005753 putative peptidase; Provisional; Region: PRK11649 550538005754 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 550538005755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538005756 Peptidase family M23; Region: Peptidase_M23; pfam01551 550538005757 HMMPfam hit to PF08525, Opacity-associated protein A, N-terminal, score 3.6e-07 550538005758 1 probable transmembrane helix predicted for SG1162 by TMHMM2.0 at aa 21-40 550538005759 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 3.8e-06 550538005760 HMMPfam hit to PF01551, Peptidase M23B, score 6e-59 550538005761 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 550538005762 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 550538005763 putative acyl-acceptor binding pocket; other site 550538005764 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltransferase, score 2.8e-155 550538005765 1 probable transmembrane helix predicted for SG1163 by TMHMM2.0 at aa 21-43 550538005766 pyruvate kinase; Provisional; Region: PRK05826 550538005767 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 550538005768 domain interfaces; other site 550538005769 active site 550538005770 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta, score 4.9e-60 550538005771 HMMPfam hit to PF00224, Pyruvate kinase, barrel, score 1.1e-225 550538005772 PS00110 Pyruvate kinase active site signature. 550538005773 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 550538005774 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 550538005775 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 550538005776 putative active site [active] 550538005777 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 5.2e-37 550538005778 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 1.1e-53 550538005779 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 550538005780 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 550538005781 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 550538005782 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, score 6.6e-104 550538005783 PS00069 Glucose-6-phosphate dehydrogenase active site. 550538005784 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, score 7.6e-204 550538005785 phosphogluconate dehydratase; Validated; Region: PRK09054 550538005786 6-phosphogluconate dehydratase; Region: edd; TIGR01196 550538005787 HMMPfam hit to PF00920, Dihydroxy-acid and 6-phosphogluconate dehydratase, score 9.1e-283 550538005788 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 550538005789 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 550538005790 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 550538005791 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 550538005792 active site 550538005793 intersubunit interface [polypeptide binding]; other site 550538005794 catalytic residue [active] 550538005795 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.9e-137 550538005796 PS00159 KDPG and KHG aldolases active site. 550538005797 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 550538005798 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 550538005799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 550538005800 ATP-grasp domain; Region: ATP-grasp; pfam02222 550538005801 HMMPfam hit to PF02222, ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type, score 3.1e-101 550538005802 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 550538005803 HMMPfam hit to PF07130, YebG, score 1.5e-49 550538005804 hypothetical protein; Provisional; Region: PRK13680 550538005805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 550538005806 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 550538005807 putative metal binding site [ion binding]; other site 550538005808 HMMPfam hit to PF04391, Protein of unknown function DUF533, score 3.4e-102 550538005809 1 probable transmembrane helix predicted for SG1172 by TMHMM2.0 at aa 52-74 550538005810 protease 2; Provisional; Region: PRK10115 550538005811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 550538005812 HMMPfam hit to PF02897, Peptidase S9A, oligopeptidase, N-terminal beta-propeller, score 9.9e-155 550538005813 HMMPfam hit to PF00326, Peptidase S9, prolyl oligopeptidase active site region, score 6.4e-103 550538005814 PS00708 Prolyl endopeptidase family serine active site. 550538005815 exodeoxyribonuclease X; Provisional; Region: PRK07983 550538005816 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 550538005817 active site 550538005818 catalytic site [active] 550538005819 substrate binding site [chemical binding]; other site 550538005820 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 4.2e-21 550538005821 Predicted amidohydrolase [General function prediction only]; Region: COG0388 550538005822 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 550538005823 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 2.1e-07 550538005824 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 550538005825 HMMPfam hit to PF06440, DNA polymerase III-theta, bacterial, score 5.6e-51 550538005826 hypothetical protein; Provisional; Region: PRK10301 550538005827 HMMPfam hit to PF04234, Copper resistance protein CopC, core, score 1.2e-56 550538005828 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 550538005829 PS00430 TonB-dependent receptor proteins signature 1. 550538005830 HMMPfam hit to PF05425, Copper resistance D, score 4.5e-136 550538005831 8 probable transmembrane helices predicted for SG1178 by TMHMM2.0 at aa 10-32, 52-74, 94-113, 120-137, 152-174, 195-217, 227-249 and 270-288 550538005832 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005833 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 550538005834 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 550538005835 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 550538005836 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 550538005837 dimer interface [polypeptide binding]; other site 550538005838 active site 550538005839 Int/Topo IB signature motif; other site 550538005840 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 6.4e-07 550538005841 Gifsy-2-like prophage remnant; carries the Type III effector protein SopE as well as pipA, ompX and sodCI. 550538005842 HMMPfam hit to PF09003, Integrase, lambda-type, N-terminal DNA-binding, score 2.2e-27 550538005843 Excisionase-like protein; Region: Exc; pfam07825 550538005844 HMMPfam hit to PF07825, Excisionase-like, score 5e-11 550538005845 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 550538005846 HMMPfam hit to PF03837, RecT protein, score 1.2e-83 550538005847 exonuclease VIII; Reviewed; Region: PRK09709 550538005848 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 550538005849 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 550538005850 HMMPfam hit to PF06630, Enterobacterial exodeoxyribonuclease VIII, score 2.1e-72 550538005851 PS00678 Trp-Asp (WD) repeats signature. 550538005852 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 550538005853 transcriptional repressor DicA; Reviewed; Region: PRK09706 550538005854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538005855 non-specific DNA binding site [nucleotide binding]; other site 550538005856 salt bridge; other site 550538005857 sequence-specific DNA binding site [nucleotide binding]; other site 550538005858 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2e-09 550538005859 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 550538005860 HMMPfam hit to PF06254, Protein of unknown function DUF1019, score 4.5e-15 550538005861 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 550538005862 primosomal protein DnaI; Provisional; Region: PRK02854 550538005863 HMMPfam hit to PF07120, Protein of unknown function DUF1376, score 6.9e-48 550538005865 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 550538005866 HMMPfam hit to PF06163, Protein of unknown function DUF977, bacterial, score 2.3e-29 550538005867 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 550538005868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538005869 metal binding site [ion binding]; metal-binding site 550538005870 active site 550538005871 I-site; other site 550538005872 HMMPfam hit to PF00990, GGDEF, score 9.8e-69 550538005873 5 probable transmembrane helices predicted for SG1195 by TMHMM2.0 at aa 37-59, 79-97, 104-126, 146-168 and 175-197 550538005874 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 550538005875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 550538005876 HMMPfam hit to PF00753, Beta-lactamase-like, score 7.5e-14 550538005878 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 550538005879 HMMPfam hit to PF07105, Protein of unknown function DUF1367, score 3.3e-142 550538005881 HMMPfam hit to PF05766, Bacteriophage Lambda NinG, score 1.9e-19 550538005882 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 550538005883 HMMPfam hit to PF06323, Phage antitermination Q, score 1.8e-138 550538005885 1 probable transmembrane helix predicted for SG1205 by TMHMM2.0 at aa 5-27 550538005886 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005887 PipA protein; Region: PipA; pfam07108 550538005888 HMMPfam hit to PF07108, PipA, score 4.1e-187 550538005889 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538005890 phage holin, lambda family; Region: holin_lambda; TIGR01594 550538005891 HMMPfam hit to PF05106, Holin, phage lambda, score 9.6e-28 550538005892 2 probable transmembrane helices predicted for SG1207 by TMHMM2.0 at aa 20-39 and 52-74 550538005893 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 550538005894 catalytic residues [active] 550538005895 HMMPfam hit to PF00959, Glycoside hydrolase, family 24, score 6.3e-33 550538005896 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 550538005897 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 4e-88 550538005898 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 550538005899 HMMPfam hit to PF07278, Protein of unknown function DUF1441, score 1.2e-116 550538005900 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 550538005901 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 550538005902 HMMPfam hit to PF05876, Phage terminase GpA, score 0 550538005903 PS00017 ATP/GTP-binding site motif A (P-loop). 550538005904 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 550538005905 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 550538005906 HMMPfam hit to PF05136, Phage portal protein, lambda, score 9.7e-116 550538005907 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 550538005908 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 550538005909 oligomer interface [polypeptide binding]; other site 550538005910 active site residues [active] 550538005911 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 550538005912 HMMPfam hit to PF00574, Peptidase S14, ClpP, score 7.6e-49 550538005913 PS00012 Phosphopantetheine attachment site. 550538005914 Uncharacterized conserved protein [Function unknown]; Region: COG5471 550538005915 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 550538005916 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 550538005917 HMMPfam hit to PF06763, Prophage minor tail Z, score 8.8e-118 550538005918 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 550538005919 HMMPfam hit to PF06141, Phage minor tail U, score 4.1e-105 550538005920 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 550538005921 HMMPfam hit to PF02368, Bacterial Ig-like, group 2, score 1.3e-09 550538005922 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 550538005923 HMMPfam hit to PF06894, Phage minor tail protein G, score 2.9e-83 550538005924 Minor tail protein T; Region: Phage_tail_T; cl05636 550538005925 HMMPfam hit to PF06223, Minor tail T, score 5e-50 550538005926 Phage-related minor tail protein [Function unknown]; Region: COG5281 550538005927 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 550538005928 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 550538005929 HMMPfam hit to PF06791, Prophage tail length tape measure, score 4.7e-91 550538005930 Phage-related protein [Function unknown]; Region: COG4718 550538005931 HMMPfam hit to PF05939, Phage minor tail, score 2.1e-70 550538005932 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 550538005933 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 1.8e-06 550538005934 1 probable transmembrane helix predicted for SG1223 by TMHMM2.0 at aa 4-25 550538005935 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 550538005936 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 550538005937 E-class dimer interface [polypeptide binding]; other site 550538005938 P-class dimer interface [polypeptide binding]; other site 550538005939 active site 550538005940 Cu2+ binding site [ion binding]; other site 550538005941 Zn2+ binding site [ion binding]; other site 550538005942 HMMPfam hit to PF00080, Superoxide dismutase, copper/zinc binding, score 6.3e-37 550538005943 PS00332 Copper/Zinc superoxide dismutase signature 2. 550538005944 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005945 Phage-related protein [Function unknown]; Region: gp18; COG4672 550538005946 HMMPfam hit to PF05100, Phage minor tail protein L, score 9.4e-145 550538005947 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 550538005948 MPN+ (JAMM) motif; other site 550538005949 Zinc-binding site [ion binding]; other site 550538005950 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 550538005951 NlpC/P60 family; Region: NLPC_P60; cl17555 550538005952 HMMPfam hit to PF00877, NLP/P60, score 2.2e-23 550538005953 Phage-related protein, tail component [Function unknown]; Region: COG4723 550538005954 HMMPfam hit to PF06805, Bacteriophage lambda tail assembly I, score 7.9e-115 550538005955 1 probable transmembrane helix predicted for SG1227 by TMHMM2.0 at aa 104-126 550538005956 the sequence has been checked and is believed to be correct 550538005957 HMMPfam hit to PF00041, Fibronectin, type III, score 0.0058 550538005958 HMMPfam hit to PF09327, Protein of unknown function DUF1983, score 9.1e-29 550538005959 the sequence has been checked and is believed to be correct 550538005960 HMMPfam hit to PF08400, Prophage tail fibre N-terminal, score 1e-90 550538005961 HMMPfam hit to PF03406, Phage tail fiber repeat 2, score 9.2e-16 550538005962 HMMPfam hit to PF07484, Phage Tail Collar, score 2.2e-20 550538005963 HMMPfam hit to PF03335, Phage tail fiber repeat, score 1.9 550538005964 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.79 550538005965 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.31 550538005966 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 550538005967 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 1e-68 550538005968 type III secretion protein SopE; Provisional; Region: PRK15279 550538005969 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 550538005970 SopE GEF domain; Region: SopE_GEF; pfam07487 550538005971 HMMPfam hit to PF07487, Salmonella type III secretion SopE effector protein, score 9.1e-122 550538005972 HMMPfam hit to PF05364, Salmonella type III secretion SopE effector protein, score 9.5e-54 550538005974 HMMPfam hit to PF00239, Resolvase, N-terminal, score 1.6e-07 550538005975 SG12A (identical to S. enteritidis SE12A degenerate lambdoid prophage) 550538005976 the sequence has been checked and is believed to be correct 550538005977 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 6.3e-05 550538005979 The 5' end of this CDS has been deleted and there is a premature stop codon in the sequence 550538005980 the sequence has been checked and is believed to be correct 550538005981 1 probable transmembrane helix predicted for SG1240 by TMHMM2.0 at aa 4-21 550538005982 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 550538005983 HMMPfam hit to PF07278, Protein of unknown function DUF1441, score 9.3e-114 550538005984 the sequence has been checked and is believed to be correct 550538005985 HMMPfam hit to PF05876, Phage terminase GpA, score 5.7e-87 550538005986 the sequence has been checked and is believed to be correct 550538005987 HMMPfam hit to PF07484, Phage Tail Collar, score 3.4e-15 550538005988 the sequence has been checked and is believed to be correct 550538005989 HMMPfam hit to PF01661, Appr-1-p processing, score 1.8e-14 550538005990 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 1e-60 550538005991 the sequence has been checked and is believed to be correct 550538005992 similar to SEN4244 in AM933173 550538005994 1 probable transmembrane helix predicted for SG1248 by TMHMM2.0 at aa 10-32 550538005995 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538005997 HMMPfam hit to PF02796, Resolvase, helix-turn-helix region, score 1.3e-11 550538005998 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 550538005999 5 probable transmembrane helices predicted for SG1250 by TMHMM2.0 at aa 13-35, 45-64, 69-91, 111-133 and 146-168 550538006000 1 probable transmembrane helix predicted for SG1251 by TMHMM2.0 at aa 24-46 550538006001 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 550538006002 EamA-like transporter family; Region: EamA; pfam00892 550538006003 EamA-like transporter family; Region: EamA; pfam00892 550538006004 10 probable transmembrane helices predicted for SG1252 by TMHMM2.0 at aa 5-27, 37-54, 67-89, 93-115, 122-139, 149-167, 179-201, 211-233, 245-267 and 271-293 550538006005 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.8e-24 550538006006 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.3e-31 550538006007 the sequence has been checked and is believed to be correct 550538006008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 550538006009 MULE transposase domain; Region: MULE; pfam10551 550538006010 HMMPfam hit to PF00872, Transposase, mutator type, score 5.9e-106 550538006011 PS01007 Transposases, Mutator family, signature. 550538006012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538006013 Coenzyme A binding pocket [chemical binding]; other site 550538006014 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.1e-11 550538006015 1 probable transmembrane helix predicted for SG1259 by TMHMM2.0 at aa 30-52 550538006016 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 550538006017 HMMPfam hit to PF07166, Protein of unknown function DUF1398, score 3.5e-91 550538006018 1 probable transmembrane helix predicted for SG1260 by TMHMM2.0 at aa 32-54 550538006019 type III secretion protein SopE2; Provisional; Region: PRK15280 550538006020 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 550538006021 SopE GEF domain; Region: SopE_GEF; pfam07487 550538006022 HMMPfam hit to PF05364, Salmonella type III secretion SopE effector protein, score 6.6e-61 550538006023 HMMPfam hit to PF07487, Salmonella type III secretion SopE effector protein, score 2.2e-137 550538006024 1 probable transmembrane helix predicted for SG1262 by TMHMM2.0 at aa 7-29 550538006025 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 550538006026 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 550538006027 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.8e-16 550538006028 PS00125 Serine/threonine specific protein phosphatases signature. 550538006029 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 550538006030 HMMPfam hit to PF07358, Protein of unknown function DUF1482, score 1.7e-39 550538006031 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 550538006032 HMMPfam hit to PF07351, Protein of unknown function DUF1480, score 2e-65 550538006033 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 550538006034 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 550538006035 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 550538006036 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 1.1e-79 550538006037 PS01153 NOL1/NOP2/sun family signature. 550538006038 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 550538006039 mce related protein; Region: MCE; pfam02470 550538006040 mce related protein; Region: MCE; pfam02470 550538006041 mce related protein; Region: MCE; pfam02470 550538006042 mce related protein; Region: MCE; pfam02470 550538006043 mce related protein; Region: MCE; pfam02470 550538006044 mce related protein; Region: MCE; pfam02470 550538006045 HMMPfam hit to PF02470, Mammalian cell entry related, score 7.1e-19 550538006046 HMMPfam hit to PF02470, Mammalian cell entry related, score 5.3e-21 550538006047 HMMPfam hit to PF02470, Mammalian cell entry related, score 0.00066 550538006048 HMMPfam hit to PF02470, Mammalian cell entry related, score 7.2e-08 550538006049 HMMPfam hit to PF02470, Mammalian cell entry related, score 4.8e-13 550538006050 HMMPfam hit to PF02470, Mammalian cell entry related, score 0.0001 550538006051 HMMPfam hit to PF02470, Mammalian cell entry related, score 9.1e-30 550538006052 1 probable transmembrane helix predicted for SG1267 by TMHMM2.0 at aa 22-41 550538006053 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 550538006054 Paraquat-inducible protein A; Region: PqiA; pfam04403 550538006055 Paraquat-inducible protein A; Region: PqiA; pfam04403 550538006056 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 3.3e-98 550538006057 8 probable transmembrane helices predicted for SG1268 by TMHMM2.0 at aa 65-84, 119-141, 162-184, 188-210, 268-290, 310-339, 351-373 and 383-405 550538006058 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 2e-92 550538006059 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 550538006060 GAF domain; Region: GAF_2; pfam13185 550538006061 HMMPfam hit to PF01590, GAF, score 1.3e-08 550538006062 ProP expression regulator; Provisional; Region: PRK04950 550538006063 ProQ/FINO family; Region: ProQ; pfam04352 550538006064 HMMPfam hit to PF04352, ProQ activator of osmoprotectant transporter ProP, score 5.8e-102 550538006065 carboxy-terminal protease; Provisional; Region: PRK11186 550538006066 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 550538006067 protein binding site [polypeptide binding]; other site 550538006068 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 550538006069 Catalytic dyad [active] 550538006070 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 550538006071 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 2.7e-17 550538006072 HMMPfam hit to PF03572, Peptidase S41, score 1.9e-66 550538006073 heat shock protein HtpX; Provisional; Region: PRK05457 550538006074 HMMPfam hit to PF06509, Peptidase M48B, HtpX peptidase N-terminal, score 4.5e-55 550538006075 4 probable transmembrane helices predicted for SG1272 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 550538006076 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 5.2e-47 550538006077 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006079 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.2e-54 550538006080 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 550538006081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538006082 dimerization interface [polypeptide binding]; other site 550538006083 putative Zn2+ binding site [ion binding]; other site 550538006084 putative DNA binding site [nucleotide binding]; other site 550538006085 Bacterial transcriptional regulator; Region: IclR; pfam01614 550538006086 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 3e-29 550538006087 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 4.4e-65 550538006088 PS01051 Bacterial regulatory proteins, iclR family signature. 550538006089 YobH-like protein; Region: YobH; pfam13996 550538006090 1 probable transmembrane helix predicted for SG1276 by TMHMM2.0 at aa 7-29 550538006091 PhoPQ regulatory protein; Provisional; Region: PRK10299 550538006092 1 probable transmembrane helix predicted for SG1277 by TMHMM2.0 at aa 7-26 550538006093 YebO-like protein; Region: YebO; pfam13974 550538006094 1 probable transmembrane helix predicted for SG1278 by TMHMM2.0 at aa 10-32 550538006095 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 550538006096 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 550538006097 DNA-binding site [nucleotide binding]; DNA binding site 550538006098 RNA-binding motif; other site 550538006099 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 3.2e-43 550538006100 PS00352 'Cold-shock' DNA-binding domain signature. 550538006101 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 550538006102 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 550538006103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 550538006104 1 probable transmembrane helix predicted for SG1281 by TMHMM2.0 at aa 16-38 550538006105 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 2.9e-53 550538006106 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 4.8e-107 550538006107 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 550538006108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538006109 S-adenosylmethionine binding site [chemical binding]; other site 550538006110 HMMPfam hit to PF08241, Methyltransferase type 11, score 8.5e-18 550538006111 hypothetical protein; Provisional; Region: PRK11469 550538006112 Domain of unknown function DUF; Region: DUF204; pfam02659 550538006113 Domain of unknown function DUF; Region: DUF204; pfam02659 550538006114 6 probable transmembrane helices predicted for SG1283 by TMHMM2.0 at aa 18-40, 57-79, 89-111, 124-146, 151-173 and 186-205 550538006115 HMMPfam hit to PF02659, Protein of unknown function DUF204, score 1.8e-33 550538006116 HMMPfam hit to PF02659, Protein of unknown function DUF204, score 5e-39 550538006117 the sequence has been checked and is believed to be correct 550538006118 HMMPfam hit to PF06173, Protein of unknown function DUF986, score 2.8e-97 550538006119 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 550538006120 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 5.7e-186 550538006121 5 probable transmembrane helices predicted for SG1285 by TMHMM2.0 at aa 105-127, 142-164, 185-207, 236-258 and 265-284 550538006122 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 550538006123 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 4.7e-149 550538006124 7 probable transmembrane helices predicted for SG1286 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 143-165, 178-200 and 215-237 550538006125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538006126 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 550538006127 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 550538006128 active pocket/dimerization site; other site 550538006129 active site 550538006130 phosphorylation site [posttranslational modification] 550538006131 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 550538006132 active site 550538006133 phosphorylation site [posttranslational modification] 550538006134 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 5.2e-97 550538006135 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 2.4e-52 550538006136 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 550538006137 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 550538006138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 550538006139 Transporter associated domain; Region: CorC_HlyC; smart01091 550538006140 HMMPfam hit to PF03741, Integral membrane protein TerC, score 1.3e-36 550538006141 7 probable transmembrane helices predicted for SG1289 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 150-172, 185-207 and 212-231 550538006142 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 5.9e-22 550538006143 HMMPfam hit to PF03471, Transporter-associated region, score 1e-18 550538006144 phage resistance protein; Provisional; Region: PRK10551 550538006145 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 550538006146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538006147 HMMPfam hit to PF00563, EAL, score 1.9e-110 550538006148 1 probable transmembrane helix predicted for SG1290 by TMHMM2.0 at aa 13-35 550538006149 L-serine deaminase; Provisional; Region: PRK15023 550538006150 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 550538006151 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 550538006152 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.3e-205 550538006153 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 1.6e-105 550538006154 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 550538006155 putative active site [active] 550538006156 putative CoA binding site [chemical binding]; other site 550538006157 nudix motif; other site 550538006158 metal binding site [ion binding]; metal-binding site 550538006159 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.7e-18 550538006160 PS01293 Uncharacterized protein family UPF0035 signature. 550538006161 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 550538006162 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 550538006163 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 550538006164 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 8.5e-142 550538006165 HMMPfam hit to PF04715, Anthranilate synthase component I, N-terminal, score 2.3e-34 550538006166 hypothetical protein; Provisional; Region: PRK05114 550538006167 HMMPfam hit to PF03701, Protein of unknown function UPF0181, score 7.9e-31 550538006168 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 550538006169 homotrimer interaction site [polypeptide binding]; other site 550538006170 putative active site [active] 550538006171 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.1e-35 550538006172 PS01094 Uncharacterized protein family UPF0076 signature. 550538006173 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 550538006174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 550538006175 DEAD_2; Region: DEAD_2; pfam06733 550538006176 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 550538006177 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006178 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 550538006179 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006180 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 550538006181 Glycoprotease family; Region: Peptidase_M22; pfam00814 550538006182 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 5.7e-57 550538006183 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 550538006184 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538006185 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp, score 1.7e-92 550538006186 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 550538006187 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 550538006188 acyl-activating enzyme (AAE) consensus motif; other site 550538006189 putative AMP binding site [chemical binding]; other site 550538006190 putative active site [active] 550538006191 putative CoA binding site [chemical binding]; other site 550538006192 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 3.9e-137 550538006193 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538006194 PS00455 AMP-binding domain signature. 550538006195 ribonuclease D; Provisional; Region: PRK10829 550538006196 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 550538006197 catalytic site [active] 550538006198 putative active site [active] 550538006199 putative substrate binding site [chemical binding]; other site 550538006200 HRDC domain; Region: HRDC; cl02578 550538006201 HMMPfam hit to PF01612, 3'-5' exonuclease, score 7.6e-70 550538006202 HMMPfam hit to PF00570, Helicase and RNase D C-terminal, HRDC, score 3.2e-23 550538006203 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 550538006204 HMMPfam hit to PF03776, Septum formation topological specificity factor MinE, score 2.5e-54 550538006205 cell division inhibitor MinD; Provisional; Region: PRK10818 550538006206 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 550538006207 Switch I; other site 550538006208 Switch II; other site 550538006209 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 3.1e-27 550538006210 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006211 septum formation inhibitor; Reviewed; Region: minC; PRK03511 550538006212 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 550538006213 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 550538006214 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 5.8e-62 550538006215 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 2.2e-49 550538006216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 550538006217 HMMPfam hit to PF05166, Protein of unknown function DUF709, score 2.7e-58 550538006218 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 550538006219 hypothetical protein; Provisional; Region: PRK10691 550538006220 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 6.2e-85 550538006221 hypothetical protein; Provisional; Region: PRK05170 550538006222 HMMPfam hit to PF03692, Protein of unknown function UPF0153, score 4.1e-23 550538006223 GnsA/GnsB family; Region: GnsAB; pfam08178 550538006224 HMMPfam hit to PF08178, GnsAGnsB, score 7.3e-31 550538006225 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 550538006226 HMMPfam hit to PF09313, Protein of unknown function DUF1971, score 2.8e-43 550538006227 disulfide bond formation protein B; Provisional; Region: PRK01749 550538006228 4 probable transmembrane helices predicted for SG1310 by TMHMM2.0 at aa 13-32, 42-64, 71-93 and 144-166 550538006229 HMMPfam hit to PF02600, Disulphide bond formation protein DsbB, score 1.1e-74 550538006230 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 550538006231 transmembrane helices; other site 550538006232 HMMPfam hit to PF06450, Na+/H+ antiporter NhaB, score 0 550538006233 12 probable transmembrane helices predicted for SG1311 by TMHMM2.0 at aa 26-48, 61-83, 93-115, 128-145, 150-169, 197-219, 239-261, 299-331, 346-368, 389-411, 453-472 and 479-501 550538006234 fatty acid metabolism regulator; Provisional; Region: PRK04984 550538006235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538006236 DNA-binding site [nucleotide binding]; DNA binding site 550538006237 FadR C-terminal domain; Region: FadR_C; pfam07840 550538006238 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 7.4e-26 550538006239 PS00043 Bacterial regulatory proteins, gntR family signature. 550538006240 HMMPfam hit to PF07840, Fatty acid responsive transcription factor FadR, C-terminal, score 4e-120 550538006241 SpoVR family protein; Provisional; Region: PRK11767 550538006242 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 550538006243 HMMPfam hit to PF04293, Sporulation stage V, protein R, score 0 550538006244 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 550538006245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 550538006246 alanine racemase; Reviewed; Region: dadX; PRK03646 550538006247 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 550538006248 active site 550538006249 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538006250 substrate binding site [chemical binding]; other site 550538006251 catalytic residues [active] 550538006252 dimer interface [polypeptide binding]; other site 550538006253 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.5e-111 550538006254 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.5e-83 550538006255 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 550538006256 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 4.5e-62 550538006257 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 550538006258 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 550538006259 TrkA-C domain; Region: TrkA_C; pfam02080 550538006260 Transporter associated domain; Region: CorC_HlyC; smart01091 550538006261 HMMPfam hit to PF03471, Transporter-associated region, score 1.4e-23 550538006262 HMMPfam hit to PF02080, TrkA-C, score 2.5e-11 550538006263 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 1.9e-72 550538006264 11 probable transmembrane helices predicted for SG1315 by TMHMM2.0 at aa 4-26, 31-53, 57-74, 87-109, 119-141, 187-209, 232-254, 267-289, 299-321, 334-356 and 361-383 550538006265 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 550538006266 dimer interface [polypeptide binding]; other site 550538006267 catalytic triad [active] 550538006268 HMMPfam hit to PF02016, Peptidase S66, LD-carboxypeptidase A, score 1e-57 550538006269 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 550538006270 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538006271 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538006272 catalytic residue [active] 550538006273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538006274 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1.4e-38 550538006275 PS00922 Prokaryotic transglycosylases signature. 550538006276 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 550538006277 Flagellar regulator YcgR; Region: YcgR; pfam07317 550538006278 PilZ domain; Region: PilZ; pfam07238 550538006279 HMMPfam hit to PF07238, Type IV pilus assembly PilZ, score 6.1e-11 550538006280 HMMPfam hit to PF07317, YcgR, score 6e-63 550538006281 hypothetical protein; Provisional; Region: PRK10457 550538006282 3 probable transmembrane helices predicted for SG1319 by TMHMM2.0 at aa 4-22, 27-49 and 59-81 550538006283 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 5.7e-20 550538006284 trehalase; Provisional; Region: treA; PRK13271 550538006285 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 550538006286 HMMPfam hit to PF01204, Glycoside hydrolase, family 37, score 5.3e-259 550538006287 PS00928 Trehalase signature 2. 550538006288 PS00927 Trehalase signature 1. 550538006289 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 550538006290 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 550538006291 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 550538006292 NAD(P) binding site [chemical binding]; other site 550538006293 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C-terminal, score 7.3e-110 550538006294 PS00137 Serine proteases, subtilase family, histidine active site. 550538006295 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 2.2e-66 550538006296 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 550538006297 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 550538006298 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 550538006299 HMMPfam hit to PF02322, Cytochrome bd ubiquinol oxidase, subunit II, score 7.1e-191 550538006300 8 probable transmembrane helices predicted for SG1323 by TMHMM2.0 at aa 7-24, 80-102, 123-145, 165-187, 208-230, 258-280, 292-314 and 334-356 550538006301 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 550538006302 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 550538006303 HMMPfam hit to PF01654, Cytochrome bd ubiquinol oxidase, subunit I, score 0 550538006304 9 probable transmembrane helices predicted for SG1324 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 125-147, 186-208, 215-237, 387-409, 421-443 and 471-493 550538006305 the sequence has been checked and is believed to be correct 550538006306 HMMPfam hit to PF04809, HupH hydrogenase expression protein, C-terminal conserved region, score 2.7e-61 550538006307 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 550538006308 HMMPfam hit to PF07449, Hydrogenase-1 expression HyaE, score 5.1e-63 550538006309 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 550538006310 putative substrate-binding site; other site 550538006311 nickel binding site [ion binding]; other site 550538006312 HMMPfam hit to PF01750, Peptidase A31, hydrogen uptake protein, score 2.6e-51 550538006313 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 550538006314 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 4.4e-77 550538006315 4 probable transmembrane helices predicted for SG1328 by TMHMM2.0 at aa 28-47, 67-89, 141-160 and 194-211 550538006316 PS00883 Nickel-dependent hydrogenases b-type cytochrome subunit signature 2. 550538006317 hydrogenase 1 large subunit; Provisional; Region: PRK10170 550538006318 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 550538006319 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, large subunit, score 0 550538006320 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 550538006321 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 550538006322 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 550538006323 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 550538006324 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 550538006325 2 probable transmembrane helices predicted for SG1330 by TMHMM2.0 at aa 20-39 and 326-348 550538006326 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 7.3e-17 550538006327 HMMPfam hit to PF08425, NiFe dehydrogenase small subunit, N-terminal, score 2.4e-46 550538006328 2 probable transmembrane helices predicted for SG1331 by TMHMM2.0 at aa 12-34 and 44-61 550538006329 PS00881 Protein splicing signature. 550538006330 3 probable transmembrane helices predicted for SG1332 by TMHMM2.0 at aa 26-45, 91-108 and 113-135 550538006331 GTP-binding protein YchF; Reviewed; Region: PRK09601 550538006332 YchF GTPase; Region: YchF; cd01900 550538006333 G1 box; other site 550538006334 GTP/Mg2+ binding site [chemical binding]; other site 550538006335 Switch I region; other site 550538006336 G2 box; other site 550538006337 Switch II region; other site 550538006338 G3 box; other site 550538006339 G4 box; other site 550538006340 G5 box; other site 550538006341 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 550538006342 HMMPfam hit to PF06071, Protein of unknown function DUF933, score 3.4e-60 550538006343 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.4e-31 550538006344 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006345 PS00443 Glutamine amidotransferases class-II active site. 550538006346 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 550538006347 putative active site [active] 550538006348 catalytic residue [active] 550538006349 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 7.9e-111 550538006350 PS00217 Sugar transport proteins signature 2. 550538006351 PS01196 Peptidyl-tRNA hydrolase signature 2. 550538006352 hypothetical protein; Provisional; Region: PRK10692 550538006353 2 probable transmembrane helices predicted for SG1335 by TMHMM2.0 at aa 7-29 and 39-61 550538006354 putative transporter; Provisional; Region: PRK11660 550538006355 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 550538006356 Sulfate transporter family; Region: Sulfate_transp; pfam00916 550538006357 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 550538006358 HMMPfam hit to PF01740, Sulphate transporter/antisigma-factor antagonist STAS, score 7.3e-23 550538006359 HMMPfam hit to PF00916, Sulphate transporter, score 5.3e-105 550538006360 10 probable transmembrane helices predicted for SG1336 by TMHMM2.0 at aa 25-47, 91-113, 122-144, 169-191, 204-226, 269-291, 311-333, 338-360, 362-380 and 400-431 550538006361 PS01130 Sulfate transporters signature. 550538006362 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 550538006363 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 550538006364 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538006365 active site 550538006366 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.1e-37 550538006367 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538006368 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 550538006369 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538006370 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 550538006371 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 550538006372 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 9.4e-08 550538006373 HMMPfam hit to PF00288, GHMP kinase, score 3e-18 550538006374 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 550538006375 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 550538006376 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 2.5e-84 550538006377 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006378 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538006379 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 550538006380 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 550538006381 tRNA; other site 550538006382 putative tRNA binding site [nucleotide binding]; other site 550538006383 putative NADP binding site [chemical binding]; other site 550538006384 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 550538006385 HMMPfam hit to PF05201, Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal, score 2.3e-86 550538006386 PS00747 Glutamyl-tRNA reductase signature. 550538006387 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 3.4e-69 550538006388 HMMPfam hit to PF00745, Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, C-terminal, score 2.5e-37 550538006389 peptide chain release factor 1; Validated; Region: prfA; PRK00591 550538006390 This domain is found in peptide chain release factors; Region: PCRF; smart00937 550538006391 RF-1 domain; Region: RF-1; pfam00472 550538006392 HMMPfam hit to PF03462, PCRF, score 9.6e-75 550538006393 HMMPfam hit to PF00472, Class I peptide chain release factor, score 3.2e-74 550538006394 PS00745 Prokaryotic-type class I peptide chain release factors signature. 550538006395 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 550538006396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538006397 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.6e-08 550538006398 PS00092 N-6 Adenine-specific DNA methylases signature. 550538006399 hypothetical protein; Provisional; Region: PRK10278 550538006400 HMMPfam hit to PF04247, Invasion gene expression up-regulator, SirB, score 1.5e-59 550538006401 4 probable transmembrane helices predicted for SG1343 by TMHMM2.0 at aa 5-27, 39-60, 70-92 and 104-123 550538006402 hypothetical protein; Provisional; Region: PRK10941 550538006403 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 550538006404 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 550538006405 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 550538006406 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 2.9e-116 550538006407 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 550538006408 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 550538006409 11 probable transmembrane helices predicted for SG1346 by TMHMM2.0 at aa 13-32, 36-58, 71-93, 108-127, 139-161, 166-188, 220-237, 247-269, 290-312, 317-339 and 346-365 550538006410 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 6.1e-14 550538006411 cation transport regulator; Reviewed; Region: chaB; PRK09582 550538006412 HMMPfam hit to PF06150, ChaB, score 7.2e-11 550538006413 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 550538006414 HMMPfam hit to PF02635, DsrE-like protein, score 1.6e-38 550538006415 putative invasin; Provisional; Region: PRK10177 550538006416 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 550538006417 transcriptional regulator NarL; Provisional; Region: PRK10651 550538006418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538006419 active site 550538006420 phosphorylation site [posttranslational modification] 550538006421 intermolecular recognition site; other site 550538006422 dimerization interface [polypeptide binding]; other site 550538006423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538006424 DNA binding residues [nucleotide binding] 550538006425 dimerization interface [polypeptide binding]; other site 550538006426 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 7.1e-27 550538006427 PS00622 Bacterial regulatory proteins, luxR family signature. 550538006428 HMMPfam hit to PF00072, Response regulator receiver, score 1.8e-42 550538006429 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 550538006430 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 550538006431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538006432 dimerization interface [polypeptide binding]; other site 550538006433 Histidine kinase; Region: HisKA_3; pfam07730 550538006434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538006435 ATP binding site [chemical binding]; other site 550538006436 Mg2+ binding site [ion binding]; other site 550538006437 G-X-G motif; other site 550538006438 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.2e-23 550538006439 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 8.9e-20 550538006440 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.2e-12 550538006441 2 probable transmembrane helices predicted for SG1351 by TMHMM2.0 at aa 15-37 and 154-176 550538006442 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 550538006443 12 probable transmembrane helices predicted for SG1352 by TMHMM2.0 at aa 38-60, 75-97, 104-123, 133-155, 176-198, 213-235, 256-278, 288-310, 322-344, 348-370, 404-421 and 436-458 550538006444 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.1e-15 550538006445 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 550538006446 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 550538006447 [4Fe-4S] binding site [ion binding]; other site 550538006448 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538006449 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538006450 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538006451 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 550538006452 molybdopterin cofactor binding site; other site 550538006453 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538006454 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 7.4e-178 550538006455 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538006456 PS00037 Myb DNA-binding domain repeat signature 1. 550538006457 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 6.5e-25 550538006458 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538006459 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 550538006460 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.011 550538006461 PS00190 Cytochrome c family heme-binding site signature. 550538006462 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 550538006463 HMMPfam hit to PF02613, Nitrate reductase, delta subunit, score 6.1e-88 550538006464 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 550538006465 HMMPfam hit to PF02665, Nitrate reductase, gamma subunit, score 8.5e-120 550538006466 5 probable transmembrane helices predicted for SG1356 by TMHMM2.0 at aa 4-26, 47-69, 89-108, 127-149 and 184-206 550538006467 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538006468 Sel1-like repeats; Region: SEL1; smart00671 550538006469 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538006470 Sel1-like repeats; Region: SEL1; smart00671 550538006471 Sel1-like repeats; Region: SEL1; smart00671 550538006472 Sel1-like repeats; Region: SEL1; smart00671 550538006473 Sel1-like repeats; Region: SEL1; smart00671 550538006474 Sel1-like repeats; Region: SEL1; smart00671 550538006475 Sel1-like repeats; Region: SEL1; smart00671 550538006476 Sel1-like repeats; Region: SEL1; smart00671 550538006477 Sel1 repeat; Region: Sel1; cl02723 550538006478 HMMPfam hit to PF08238, Sel1-like, score 1.4e-09 550538006479 HMMPfam hit to PF08238, Sel1-like, score 1.9e-06 550538006480 HMMPfam hit to PF08238, Sel1-like, score 0.00019 550538006481 HMMPfam hit to PF08238, Sel1-like, score 4.4e-07 550538006482 HMMPfam hit to PF08238, Sel1-like, score 0.00014 550538006483 HMMPfam hit to PF08238, Sel1-like, score 8.6e-07 550538006484 HMMPfam hit to PF08238, Sel1-like, score 1e-10 550538006485 HMMPfam hit to PF08238, Sel1-like, score 8.2e-09 550538006486 HMMPfam hit to PF08238, Sel1-like, score 1e-10 550538006487 HMMPfam hit to PF08238, Sel1-like, score 7.1e-06 550538006488 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 550538006489 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 550538006490 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 550538006491 putative active site [active] 550538006492 putative substrate binding site [chemical binding]; other site 550538006493 putative cosubstrate binding site; other site 550538006494 catalytic site [active] 550538006495 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 1e-77 550538006496 HMMPfam hit to PF01842, Amino acid-binding ACT, score 2.2e-06 550538006497 SEC-C motif; Region: SEC-C; pfam02810 550538006498 hypothetical protein; Provisional; Region: PRK04233 550538006499 HMMPfam hit to PF02810, SEC-C motif, score 3.8e-06 550538006500 HMMPfam hit to PF02810, SEC-C motif, score 2.3e-07 550538006501 hypothetical protein; Provisional; Region: PRK10279 550538006502 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 550538006503 active site 550538006504 nucleophile elbow; other site 550538006505 HMMPfam hit to PF01734, Patatin, score 5.5e-54 550538006506 PS01237 Uncharacterized protein family UPF0028 signature. 550538006507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538006508 active site 550538006509 response regulator of RpoS; Provisional; Region: PRK10693 550538006510 phosphorylation site [posttranslational modification] 550538006511 intermolecular recognition site; other site 550538006512 dimerization interface [polypeptide binding]; other site 550538006513 HMMPfam hit to PF00072, Response regulator receiver, score 9.7e-43 550538006514 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 550538006515 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 550538006516 active site 550538006517 tetramer interface; other site 550538006518 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.6e-12 550538006519 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006520 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 550538006521 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 550538006522 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 1.2e-48 550538006523 thymidine kinase; Provisional; Region: PRK04296 550538006524 HMMPfam hit to PF00265, Thymidine kinase, score 6.9e-103 550538006525 PS00603 Thymidine kinase cellular-type signature. 550538006526 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 550538006527 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 550538006528 putative catalytic cysteine [active] 550538006529 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 550538006530 putative active site [active] 550538006531 metal binding site [ion binding]; metal-binding site 550538006532 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 4.7e-239 550538006533 PS00060 Iron-containing alcohol dehydrogenases signature 2. 550538006534 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538006535 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 4.2e-08 550538006536 hypothetical protein; Provisional; Region: PRK11111 550538006537 HMMPfam hit to PF01914, Multiple antibiotic resistance (MarC)-related proteins, score 1.2e-105 550538006538 6 probable transmembrane helices predicted for SG1368 by TMHMM2.0 at aa 10-32, 52-74, 78-100, 120-142, 146-168 and 189-211 550538006539 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 550538006540 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 550538006541 peptide binding site [polypeptide binding]; other site 550538006542 1 probable transmembrane helix predicted for SG1369 by TMHMM2.0 at aa 9-31 550538006543 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.4e-86 550538006544 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 550538006545 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 550538006546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538006547 dimer interface [polypeptide binding]; other site 550538006548 conserved gate region; other site 550538006549 putative PBP binding loops; other site 550538006550 ABC-ATPase subunit interface; other site 550538006551 6 probable transmembrane helices predicted for SG1370 by TMHMM2.0 at aa 13-30, 102-121, 134-156, 166-188, 228-250 and 278-300 550538006552 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.5e-55 550538006553 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538006554 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 550538006555 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 550538006556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538006557 dimer interface [polypeptide binding]; other site 550538006558 conserved gate region; other site 550538006559 ABC-ATPase subunit interface; other site 550538006560 6 probable transmembrane helices predicted for SG1371 by TMHMM2.0 at aa 40-62, 103-125, 138-160, 164-183, 214-236 and 268-290 550538006561 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.6e-40 550538006562 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538006563 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 550538006564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538006565 Walker A/P-loop; other site 550538006566 ATP binding site [chemical binding]; other site 550538006567 Q-loop/lid; other site 550538006568 ABC transporter signature motif; other site 550538006569 Walker B; other site 550538006570 D-loop; other site 550538006571 H-loop/switch region; other site 550538006572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 550538006573 HMMPfam hit to PF00005, ABC transporter related, score 9.2e-66 550538006574 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006575 PS00211 ABC transporters family signature. 550538006576 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 7e-31 550538006577 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 550538006578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538006579 Walker A/P-loop; other site 550538006580 ATP binding site [chemical binding]; other site 550538006581 Q-loop/lid; other site 550538006582 ABC transporter signature motif; other site 550538006583 Walker B; other site 550538006584 D-loop; other site 550538006585 H-loop/switch region; other site 550538006586 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 550538006587 HMMPfam hit to PF00005, ABC transporter related, score 6.5e-62 550538006588 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006589 PS00211 ABC transporters family signature. 550538006590 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 2.4e-35 550538006591 Ion transport protein; Region: Ion_trans; pfam00520 550538006592 Ion channel; Region: Ion_trans_2; pfam07885 550538006593 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 550538006594 Double zinc ribbon; Region: DZR; pfam12773 550538006595 6 probable transmembrane helices predicted for SG1374 by TMHMM2.0 at aa 12-34, 44-66, 73-95, 139-161, 166-188 and 198-220 550538006596 HMMPfam hit to PF00520, Ion transport, score 1.6e-29 550538006597 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 550538006598 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 550538006599 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 550538006600 putative active site [active] 550538006601 catalytic site [active] 550538006602 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 550538006603 putative active site [active] 550538006604 catalytic site [active] 550538006605 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 6.4e-08 550538006606 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 8.1e-08 550538006607 2 probable transmembrane helices predicted for SG1376 by TMHMM2.0 at aa 10-29 and 36-58 550538006608 YciI-like protein; Reviewed; Region: PRK11370 550538006609 HMMPfam hit to PF03795, YCII-related, score 4.3e-44 550538006610 transport protein TonB; Provisional; Region: PRK10819 550538006611 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 550538006612 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 1.7e-17 550538006613 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 550538006614 HMMPfam hit to PF03061, Thioesterase superfamily, score 6e-21 550538006615 intracellular septation protein A; Reviewed; Region: PRK00259 550538006616 HMMPfam hit to PF04279, Intracellular septation protein A, score 1.5e-116 550538006617 5 probable transmembrane helices predicted for SG1380 by TMHMM2.0 at aa 20-42, 51-68, 78-95, 119-141 and 151-170 550538006618 hypothetical protein; Provisional; Region: PRK02868 550538006619 HMMPfam hit to PF06790, Protein of unknown function UPF0259, score 2.7e-152 550538006620 6 probable transmembrane helices predicted for SG1381 by TMHMM2.0 at aa 20-42, 89-111, 118-140, 144-166, 187-209 and 219-241 550538006621 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 550538006622 HMMPfam hit to PF03692, Protein of unknown function UPF0153, score 6.1e-26 550538006623 outer membrane protein W; Provisional; Region: PRK10959 550538006624 HMMPfam hit to PF03922, Outer membrane protein, OmpW, score 4.1e-107 550538006625 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 550538006626 dimanganese center [ion binding]; other site 550538006627 HMMPfam hit to PF05067, Catalase, manganese, score 8e-132 550538006628 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 550538006629 dinuclear metal binding motif [ion binding]; other site 550538006630 HMMPfam hit to PF05974, Protein of unknown function DUF892, score 5.6e-71 550538006631 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 550538006632 dimerization interface [polypeptide binding]; other site 550538006633 metal binding site [ion binding]; metal-binding site 550538006634 HMMPfam hit to PF05974, Protein of unknown function DUF892, score 3.3e-87 550538006635 General stress protein [General function prediction only]; Region: GsiB; COG3729 550538006636 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 550538006637 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 550538006638 substrate binding site [chemical binding]; other site 550538006639 active site 550538006640 catalytic residues [active] 550538006641 heterodimer interface [polypeptide binding]; other site 550538006642 HMMPfam hit to PF00290, Tryptophan synthase, alpha chain, score 4.5e-146 550538006643 PS00167 Tryptophan synthase alpha chain signature. 550538006644 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 550538006645 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 550538006646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538006647 catalytic residue [active] 550538006648 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 3.2e-118 550538006649 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 550538006650 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 550538006651 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 550538006652 active site 550538006653 ribulose/triose binding site [chemical binding]; other site 550538006654 phosphate binding site [ion binding]; other site 550538006655 substrate (anthranilate) binding pocket [chemical binding]; other site 550538006656 product (indole) binding pocket [chemical binding]; other site 550538006657 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 550538006658 active site 550538006659 HMMPfam hit to PF00697, N-(5'phosphoribosyl)anthranilate isomerase (PRAI), score 1.1e-93 550538006660 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 2.4e-149 550538006661 PS00614 Indole-3-glycerol phosphate synthase signature. 550538006662 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 550538006663 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 550538006664 glutamine binding [chemical binding]; other site 550538006665 catalytic triad [active] 550538006666 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 550538006667 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 550538006668 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 1.2e-153 550538006669 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 1.1e-27 550538006670 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.5e-71 550538006671 PS00442 Glutamine amidotransferases class-I active site. 550538006672 anthranilate synthase component I; Provisional; Region: PRK13564 550538006673 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 550538006674 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 550538006675 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 2.3e-165 550538006676 HMMPfam hit to PF04715, Anthranilate synthase component I, N-terminal, score 1.9e-30 550538006677 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 550538006678 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 550538006679 active site 550538006680 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 550538006681 HMMPfam hit to PF02811, PHP, C-terminal, score 1.5e-38 550538006682 hypothetical protein; Provisional; Region: PRK11630 550538006683 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 4e-78 550538006684 PS01147 SUA5/yciO/yrdC family signature. 550538006685 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 550538006686 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538006687 RNA binding surface [nucleotide binding]; other site 550538006688 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 550538006689 probable active site [active] 550538006690 HMMPfam hit to PF01479, RNA-binding S4, score 8.7e-09 550538006691 HMMPfam hit to PF00849, Pseudouridine synthase, score 4.2e-12 550538006692 PS01149 Rsu family of pseudouridine synthase signature. 550538006693 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 550538006694 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 550538006695 homodimer interface [polypeptide binding]; other site 550538006696 Walker A motif; other site 550538006697 ATP binding site [chemical binding]; other site 550538006698 hydroxycobalamin binding site [chemical binding]; other site 550538006699 Walker B motif; other site 550538006700 HMMPfam hit to PF02572, Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR, score 4.4e-125 550538006701 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 550538006702 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 550538006703 NADP binding site [chemical binding]; other site 550538006704 homodimer interface [polypeptide binding]; other site 550538006705 active site 550538006706 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.2e-35 550538006707 PS00061 Short-chain dehydrogenases/reductases family signature. 550538006708 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 550538006709 putative inner membrane peptidase; Provisional; Region: PRK11778 550538006710 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 550538006711 tandem repeat interface [polypeptide binding]; other site 550538006712 oligomer interface [polypeptide binding]; other site 550538006713 active site residues [active] 550538006714 HMMPfam hit to PF08496, Peptidase S49, N-terminal proteobacteria, score 4.9e-104 550538006715 PS00043 Bacterial regulatory proteins, gntR family signature. 550538006716 2 probable transmembrane helices predicted for SG1398 by TMHMM2.0 at aa 10-32 and 189-206 550538006717 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538006718 HMMPfam hit to PF01343, Peptidase S49, score 9e-64 550538006719 hypothetical protein; Provisional; Region: PRK11037 550538006720 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 550538006721 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 550538006722 active site 550538006723 interdomain interaction site; other site 550538006724 putative metal-binding site [ion binding]; other site 550538006725 nucleotide binding site [chemical binding]; other site 550538006726 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 550538006727 domain I; other site 550538006728 DNA binding groove [nucleotide binding] 550538006729 phosphate binding site [ion binding]; other site 550538006730 domain II; other site 550538006731 domain III; other site 550538006732 nucleotide binding site [chemical binding]; other site 550538006733 catalytic site [active] 550538006734 domain IV; other site 550538006735 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 550538006736 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 550538006737 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 550538006738 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 550538006739 HMMPfam hit to PF01751, TOPRIM, score 2.8e-39 550538006740 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 2.4e-201 550538006741 PS00396 Prokaryotic DNA topoisomerase I active site. 550538006742 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 0.00056 550538006743 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 1.1e-13 550538006744 HMMPfam hit to PF08272, DNA topoisomerase I, zinc ribbon-like, bacterial-type, score 1.8e-15 550538006745 HMMPfam hit to PF08272, DNA topoisomerase I, zinc ribbon-like, bacterial-type, score 4.5e-21 550538006746 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 550538006747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538006748 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 550538006749 substrate binding site [chemical binding]; other site 550538006750 putative dimerization interface [polypeptide binding]; other site 550538006751 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.5e-15 550538006752 PS00044 Bacterial regulatory proteins, lysR family signature. 550538006753 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 550538006754 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.5e-45 550538006755 aconitate hydratase; Validated; Region: PRK09277 550538006756 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 550538006757 substrate binding site [chemical binding]; other site 550538006758 ligand binding site [chemical binding]; other site 550538006759 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 550538006760 substrate binding site [chemical binding]; other site 550538006761 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 3.3e-280 550538006762 PS00450 Aconitase family signature 1. 550538006763 PS01244 Aconitase family signature 2. 550538006764 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 5.8e-66 550538006765 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 550538006766 dimerization interface [polypeptide binding]; other site 550538006767 active site 550538006768 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 1.6e-116 550538006769 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 550538006770 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 550538006771 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 550538006772 active site 550538006773 6 probable transmembrane helices predicted for SG1404 by TMHMM2.0 at aa 9-31, 51-68, 75-92, 157-179, 186-208 and 212-229 550538006774 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 8.5e-25 550538006775 Predicted membrane protein [Function unknown]; Region: COG3771 550538006776 HMMPfam hit to PF06305, Protein of unknown function DUF1049, score 1.9e-57 550538006777 2 probable transmembrane helices predicted for SG1405 by TMHMM2.0 at aa 5-23 and 43-65 550538006778 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 550538006779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 550538006780 TPR motif; other site 550538006781 binding surface 550538006782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 550538006783 binding surface 550538006784 TPR motif; other site 550538006785 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.00032 550538006786 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 550538006787 active site 550538006788 dimer interface [polypeptide binding]; other site 550538006789 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 4.2e-85 550538006790 PS00156 Orotidine 5'-phosphate decarboxylase active site. 550538006791 translation initiation factor Sui1; Validated; Region: PRK06824 550538006792 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 550538006793 putative rRNA binding site [nucleotide binding]; other site 550538006794 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 7.2e-36 550538006795 PS01118 Translation initiation factor SUI1 signature. 550538006796 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538006797 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538006798 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538006799 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 2.7e-34 550538006800 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 3.7e-16 550538006801 RNase II stability modulator; Provisional; Region: PRK10060 550538006802 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538006803 putative active site [active] 550538006804 heme pocket [chemical binding]; other site 550538006805 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538006806 metal binding site [ion binding]; metal-binding site 550538006807 active site 550538006808 I-site; other site 550538006809 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538006810 HMMPfam hit to PF00563, EAL, score 1.2e-123 550538006811 HMMPfam hit to PF00990, GGDEF, score 2.5e-62 550538006812 exoribonuclease II; Provisional; Region: PRK05054 550538006813 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 550538006814 RNB domain; Region: RNB; pfam00773 550538006815 S1 RNA binding domain; Region: S1; pfam00575 550538006816 HMMPfam hit to PF00575, S1, RNA binding, score 4.4e-09 550538006817 HMMPfam hit to PF00773, Ribonuclease II and R, score 6.7e-129 550538006818 PS01175 Ribonuclease II family signature. 550538006819 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 4.8e-24 550538006821 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 550538006822 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 550538006823 NAD binding site [chemical binding]; other site 550538006824 homotetramer interface [polypeptide binding]; other site 550538006825 homodimer interface [polypeptide binding]; other site 550538006826 substrate binding site [chemical binding]; other site 550538006827 active site 550538006828 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 0.00042 550538006829 Note the frameshift mutation following codon 70 550538006831 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 550538006832 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 550538006833 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538006834 Walker A/P-loop; other site 550538006835 ATP binding site [chemical binding]; other site 550538006836 Q-loop/lid; other site 550538006837 ABC transporter signature motif; other site 550538006838 Walker B; other site 550538006839 D-loop; other site 550538006840 H-loop/switch region; other site 550538006841 HMMPfam hit to PF00005, ABC transporter related, score 1.5e-65 550538006842 PS00211 ABC transporters family signature. 550538006843 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006844 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 550538006845 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538006846 Walker A/P-loop; other site 550538006847 ATP binding site [chemical binding]; other site 550538006848 Q-loop/lid; other site 550538006849 ABC transporter signature motif; other site 550538006850 Walker B; other site 550538006851 D-loop; other site 550538006852 H-loop/switch region; other site 550538006853 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 550538006854 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 5.4e-24 550538006855 HMMPfam hit to PF00005, ABC transporter related, score 7.5e-68 550538006856 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006857 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 550538006858 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 550538006859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538006860 dimer interface [polypeptide binding]; other site 550538006861 conserved gate region; other site 550538006862 putative PBP binding loops; other site 550538006863 ABC-ATPase subunit interface; other site 550538006864 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.9e-30 550538006865 6 probable transmembrane helices predicted for SG1422 by TMHMM2.0 at aa 30-52, 99-121, 134-156, 198-217, 224-243 and 258-280 550538006866 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 550538006867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538006868 dimer interface [polypeptide binding]; other site 550538006869 conserved gate region; other site 550538006870 putative PBP binding loops; other site 550538006871 ABC-ATPase subunit interface; other site 550538006872 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3e-53 550538006873 4 probable transmembrane helices predicted for SG1423 by TMHMM2.0 at aa 23-45, 57-79, 194-216 and 229-251 550538006874 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 550538006875 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 550538006876 peptide binding site [polypeptide binding]; other site 550538006877 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 9.8e-71 550538006878 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 550538006879 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 550538006880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538006881 Walker A motif; other site 550538006882 ATP binding site [chemical binding]; other site 550538006883 Walker B motif; other site 550538006884 arginine finger; other site 550538006885 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 0.00016 550538006886 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538006887 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 6.5e-127 550538006888 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538006889 phage shock protein PspA; Provisional; Region: PRK10698 550538006890 HMMPfam hit to PF04012, PspA/IM30, score 7.5e-54 550538006891 phage shock protein B; Provisional; Region: pspB; PRK09458 550538006892 HMMPfam hit to PF06667, Phage shock B, score 9.8e-48 550538006893 1 probable transmembrane helix predicted for SG1427 by TMHMM2.0 at aa 4-26 550538006894 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 550538006895 phage shock protein C; Region: phageshock_pspC; TIGR02978 550538006896 HMMPfam hit to PF04024, PspC, score 2.6e-29 550538006897 1 probable transmembrane helix predicted for SG1428 by TMHMM2.0 at aa 39-61 550538006898 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 550538006899 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 550538006900 active site residue [active] 550538006901 1 probable transmembrane helix predicted for SG1430 by TMHMM2.0 at aa 5-24 550538006902 HMMPfam hit to PF00581, Rhodanese-like, score 1.8e-07 550538006903 Predicted ATPase [General function prediction only]; Region: COG3106 550538006904 HMMPfam hit to PF04317, Protein of unknown function DUF463, YcjX-like protein, score 0 550538006905 PS00017 ATP/GTP-binding site motif A (P-loop). 550538006906 hypothetical protein; Provisional; Region: PRK05415 550538006907 TIGR01620 family protein; Region: hyp_HI0043 550538006908 HMMPfam hit to PF05128, Conserved hypothetical protein CHP01620, score 1.4e-203 550538006909 3 probable transmembrane helices predicted for SG1432 by TMHMM2.0 at aa 70-89, 99-121 and 210-232 550538006910 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 550538006911 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 550538006912 putative aromatic amino acid binding site; other site 550538006913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538006914 Walker A motif; other site 550538006915 ATP binding site [chemical binding]; other site 550538006916 Walker B motif; other site 550538006917 arginine finger; other site 550538006918 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.00011 550538006919 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 3.3e-113 550538006920 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538006921 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538006922 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538006923 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 550538006924 dimer interface [polypeptide binding]; other site 550538006925 catalytic triad [active] 550538006926 peroxidatic and resolving cysteines [active] 550538006927 HMMPfam hit to PF08534, Redoxin, score 1.4e-48 550538006928 PS01265 Tpx family signature. 550538006929 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 550538006930 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 550538006931 active site 550538006932 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 9.5e-41 550538006933 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 550538006934 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 4e-18 550538006935 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 550538006936 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 550538006937 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 550538006938 putative active site [active] 550538006939 Zn binding site [ion binding]; other site 550538006940 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 1.2e-25 550538006941 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 550538006942 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 550538006943 peptide binding site [polypeptide binding]; other site 550538006944 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.3e-82 550538006945 PS01109 Ribosomal protein L10 signature. 550538006946 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 550538006947 NmrA-like family; Region: NmrA; pfam05368 550538006948 NAD(P) binding site [chemical binding]; other site 550538006949 active site lysine 550538006950 HMMPfam hit to PF05368, NmrA-like, score 9.3e-07 550538006951 1 probable transmembrane helix predicted for SG1438 by TMHMM2.0 at aa 12-34 550538006952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538006953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538006954 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 550538006955 putative effector binding pocket; other site 550538006956 putative dimerization interface [polypeptide binding]; other site 550538006957 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.3e-16 550538006958 PS00044 Bacterial regulatory proteins, lysR family signature. 550538006959 HMMPfam hit to PF03466, LysR, substrate-binding, score 5e-43 550538006960 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538006961 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538006962 active site 550538006963 catalytic tetrad [active] 550538006964 HMMPfam hit to PF00248, Aldo/keto reductase, score 6e-101 550538006965 PS00798 Aldo/keto reductase family signature 1. 550538006966 PS00062 Aldo/keto reductase family signature 2. 550538006967 PS00063 Aldo/keto reductase family active site signature. 550538006968 oxidoreductase; Provisional; Region: PRK12742 550538006969 classical (c) SDRs; Region: SDR_c; cd05233 550538006970 NAD(P) binding site [chemical binding]; other site 550538006971 active site 550538006972 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.1e-24 550538006973 PS00061 Short-chain dehydrogenases/reductases family signature. 550538006974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 550538006975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538006976 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 1.8e-10 550538006977 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 550538006978 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 1.4e-39 550538006979 1 probable transmembrane helix predicted for SG1443 by TMHMM2.0 at aa 5-27 550538006980 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538006981 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 550538006982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538006983 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 550538006984 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 1.1e-26 550538006985 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.6e-10 550538006986 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00055 550538006991 HMMPfam hit to PF03483, B3/4, score 5.7e-07 550538006992 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 550538006993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538006994 non-specific DNA binding site [nucleotide binding]; other site 550538006995 salt bridge; other site 550538006996 sequence-specific DNA binding site [nucleotide binding]; other site 550538006997 Cupin domain; Region: Cupin_2; pfam07883 550538006998 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.3e-11 550538006999 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.9e-15 550538007000 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 550538007001 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538007002 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 3.3e-74 550538007003 PS01246 Uncharacterized protein family UPF0003 signature. 550538007004 5 probable transmembrane helices predicted for SG1454 by TMHMM2.0 at aa 10-30, 39-61, 76-98, 117-134 and 138-160 550538007005 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007006 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 550538007007 2 probable transmembrane helices predicted for SG1455 by TMHMM2.0 at aa 13-35 and 60-82 550538007008 universal stress protein UspE; Provisional; Region: PRK11175 550538007009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 550538007010 Ligand Binding Site [chemical binding]; other site 550538007011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 550538007012 Ligand Binding Site [chemical binding]; other site 550538007013 HMMPfam hit to PF00582, UspA, score 1.3e-12 550538007014 HMMPfam hit to PF00582, UspA, score 4.5e-17 550538007015 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 550538007016 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 550538007017 ligand binding site [chemical binding]; other site 550538007018 flexible hinge region; other site 550538007019 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 550538007020 putative switch regulator; other site 550538007021 non-specific DNA interactions [nucleotide binding]; other site 550538007022 DNA binding site [nucleotide binding] 550538007023 sequence specific DNA binding site [nucleotide binding]; other site 550538007024 putative cAMP binding site [chemical binding]; other site 550538007025 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 1.5e-16 550538007026 PS00042 Bacterial regulatory proteins, crp family signature. 550538007027 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 1.3e-20 550538007028 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 550538007029 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 550538007030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 550538007031 DNA binding site [nucleotide binding] 550538007032 active site 550538007033 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 2e-59 550538007034 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 550538007035 HMMPfam hit to PF02870, Methylguanine DNA methyltransferase, ribonuclease-like, score 7.1e-22 550538007036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 550538007037 Smr domain; Region: Smr; pfam01713 550538007038 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 5.8e-29 550538007039 HAMP domain; Region: HAMP; pfam00672 550538007040 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 550538007041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538007042 dimer interface [polypeptide binding]; other site 550538007043 putative CheW interface [polypeptide binding]; other site 550538007044 2 probable transmembrane helices predicted for SG1460 by TMHMM2.0 at aa 7-29 and 33-55 550538007045 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 0.00089 550538007046 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 4.8e-68 550538007047 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 550538007048 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 550538007049 Cl binding site [ion binding]; other site 550538007050 oligomer interface [polypeptide binding]; other site 550538007051 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 0.00012 550538007052 2 probable transmembrane helices predicted for SG1461 by TMHMM2.0 at aa 259-281 and 291-313 550538007053 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 550538007054 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 550538007055 ATP binding site [chemical binding]; other site 550538007056 Mg++ binding site [ion binding]; other site 550538007057 motif III; other site 550538007058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538007059 nucleotide binding region [chemical binding]; other site 550538007060 ATP-binding site [chemical binding]; other site 550538007061 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 550538007062 putative RNA binding site [nucleotide binding]; other site 550538007063 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 7.1e-67 550538007064 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007065 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 550538007066 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 6.1e-31 550538007067 HMMPfam hit to PF03880, DbpA, RNA-binding, score 4.7e-32 550538007068 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 550538007069 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 550538007070 Ligand Binding Site [chemical binding]; other site 550538007071 HMMPfam hit to PF01171, PP-loop, score 6.7e-07 550538007072 this CDS has suffered a deletion event removing most of the 5' end 550538007073 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2e-06 550538007074 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 550538007075 HMMPfam hit to PF00893, Small multidrug resistance protein, score 1.3e-37 550538007076 4 probable transmembrane helices predicted for SG1465 by TMHMM2.0 at aa 5-22, 32-51, 58-80 and 90-107 550538007077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 550538007078 Ligand Binding Site [chemical binding]; other site 550538007079 HMMPfam hit to PF00582, UspA, score 1.2e-20 550538007081 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 3.9e-09 550538007082 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.9e-05 550538007083 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.2e-06 550538007084 HMMPfam hit to PF01558, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 5.4e-79 550538007085 HMMPfam hit to PF01855, Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal, score 3.1e-123 550538007086 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 550538007087 Domain of unknown function (DUF333); Region: DUF333; pfam03891 550538007088 heat-inducible protein; Provisional; Region: PRK10449 550538007089 HMMPfam hit to PF03724, Protein of unknown function DUF306, Meta and HslJ, score 3.2e-33 550538007090 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007091 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 550538007092 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 550538007093 putative ligand binding site [chemical binding]; other site 550538007094 putative NAD binding site [chemical binding]; other site 550538007095 catalytic site [active] 550538007096 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 4.4e-38 550538007097 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 1.1e-71 550538007098 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 550538007099 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 550538007100 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 550538007101 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007102 hypothetical protein; Provisional; Region: PRK10695 550538007103 1 probable transmembrane helix predicted for SG1473 by TMHMM2.0 at aa 7-29 550538007104 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 550538007105 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 550538007107 1 probable transmembrane helix predicted for SG1475 by TMHMM2.0 at aa 5-24 550538007108 HMMPfam hit to PF07027, Uncharacterised conserved protein UCP025560, score 1.8e-65 550538007109 Uncharacterized conserved protein [Function unknown]; Region: COG3791 550538007110 HMMPfam hit to PF04828, Glutathione-dependent formaldehyde-activating, GFA, score 1.1e-28 550538007111 azoreductase; Reviewed; Region: PRK00170 550538007112 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 550538007113 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.2e-61 550538007114 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 550538007115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538007116 ATP binding site [chemical binding]; other site 550538007117 putative Mg++ binding site [ion binding]; other site 550538007118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538007119 nucleotide binding region [chemical binding]; other site 550538007120 ATP-binding site [chemical binding]; other site 550538007121 Helicase associated domain (HA2); Region: HA2; pfam04408 550538007122 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 550538007123 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 550538007124 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007125 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7e-14 550538007126 HMMPfam hit to PF04408, Helicase-associated region, score 4e-29 550538007127 HMMPfam hit to PF07717, Region of unknown function DUF1605, score 4.2e-21 550538007128 Uncharacterized conserved protein [Function unknown]; Region: COG1434 550538007129 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 550538007130 putative active site [active] 550538007131 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 9e-28 550538007132 cytochrome b561; Provisional; Region: PRK11513 550538007133 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 1.6e-64 550538007134 4 probable transmembrane helices predicted for SG1480 by TMHMM2.0 at aa 5-27, 40-62, 83-105 and 140-162 550538007135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538007136 S-adenosylmethionine binding site [chemical binding]; other site 550538007137 HMMPfam hit to PF08242, Methyltransferase type 12, score 3.9e-14 550538007138 Predicted membrane protein [Function unknown]; Region: COG5305 550538007139 9 probable transmembrane helices predicted for SG1482 by TMHMM2.0 at aa 20-39, 90-112, 143-162, 172-194, 215-237, 276-298, 310-332, 336-353 and 360-377 550538007140 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538007142 dimer interface [polypeptide binding]; other site 550538007143 conserved gate region; other site 550538007144 putative PBP binding loops; other site 550538007145 ABC-ATPase subunit interface; other site 550538007146 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.9e-09 550538007147 5 probable transmembrane helices predicted for SG1483 by TMHMM2.0 at aa 30-49, 61-83, 93-115, 136-158 and 192-214 550538007148 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538007149 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 550538007150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538007151 Walker A/P-loop; other site 550538007152 ATP binding site [chemical binding]; other site 550538007153 Q-loop/lid; other site 550538007154 ABC transporter signature motif; other site 550538007155 Walker B; other site 550538007156 D-loop; other site 550538007157 H-loop/switch region; other site 550538007158 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-50 550538007159 PS00211 ABC transporters family signature. 550538007160 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007161 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538007163 dimer interface [polypeptide binding]; other site 550538007164 conserved gate region; other site 550538007165 putative PBP binding loops; other site 550538007166 ABC-ATPase subunit interface; other site 550538007167 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.2e-17 550538007168 4 probable transmembrane helices predicted for SG1485 by TMHMM2.0 at aa 20-42, 55-74, 79-101 and 186-208 550538007169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538007170 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 550538007171 substrate binding pocket [chemical binding]; other site 550538007172 membrane-bound complex binding site; other site 550538007173 hinge residues; other site 550538007174 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 5.5e-30 550538007175 Predicted membrane protein [Function unknown]; Region: COG3326 550538007176 3 probable transmembrane helices predicted for SG1487 by TMHMM2.0 at aa 2-21, 25-42 and 89-111 550538007177 HMMPfam hit to PF06961, Protein of unknown function DUF1294, score 1.1e-34 550538007178 Sif protein; Region: Sif; cl11505 550538007179 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 550538007180 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 550538007181 active site 550538007182 catalytic triad [active] 550538007183 oxyanion hole [active] 550538007184 HMMPfam hit to PF06767, Sif, score 4.4e-06 550538007185 5 probable transmembrane helices predicted for SG1489 by TMHMM2.0 at aa 12-34, 54-76, 88-110, 114-136 and 155-177 550538007186 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 550538007187 putative metal binding site [ion binding]; other site 550538007188 putative homodimer interface [polypeptide binding]; other site 550538007189 putative homotetramer interface [polypeptide binding]; other site 550538007190 putative homodimer-homodimer interface [polypeptide binding]; other site 550538007191 putative allosteric switch controlling residues; other site 550538007192 HMMPfam hit to PF02583, Protein of unknown function DUF156, score 1.7e-34 550538007193 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 550538007194 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 550538007195 substrate binding site [chemical binding]; other site 550538007196 catalytic Zn binding site [ion binding]; other site 550538007197 NAD binding site [chemical binding]; other site 550538007198 structural Zn binding site [ion binding]; other site 550538007199 dimer interface [polypeptide binding]; other site 550538007200 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 3e-39 550538007201 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538007202 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 2.9e-33 550538007203 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 550538007204 dimer interface [polypeptide binding]; other site 550538007205 ligand binding site [chemical binding]; other site 550538007206 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 550538007207 HAMP domain; Region: HAMP; pfam00672 550538007208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538007209 dimer interface [polypeptide binding]; other site 550538007210 putative CheW interface [polypeptide binding]; other site 550538007211 2 probable transmembrane helices predicted for SG1493 by TMHMM2.0 at aa 26-48 and 203-225 550538007212 HMMPfam hit to PF02203, Ligand binding Tar, score 1.9e-30 550538007213 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.2e-14 550538007214 PS00538 Bacterial chemotaxis sensory transducers signature. 550538007215 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.6e-113 550538007216 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 550538007217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538007218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538007219 dimerization interface [polypeptide binding]; other site 550538007220 HMMPfam hit to PF03466, LysR, substrate-binding, score 5.9e-37 550538007221 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.1e-19 550538007222 PS00044 Bacterial regulatory proteins, lysR family signature. 550538007223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 550538007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 550538007225 PS00237 G-protein coupled receptors signature. 550538007226 HMMPfam hit to PF07063, Protein of unknown function DUF1338, score 3.4e-71 550538007227 PS00294 Prenyl group binding site (CAAX box). 550538007228 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 550538007229 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 550538007230 substrate binding pocket [chemical binding]; other site 550538007231 catalytic triad [active] 550538007232 HMMPfam hit to PF00135, Carboxylesterase, type B, score 5.8e-99 550538007233 PS00941 Carboxylesterases type-B signature 2. 550538007234 PS00122 Carboxylesterases type-B serine active site. 550538007235 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 550538007236 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 550538007237 HMMPfam hit to PF04349, Glucan biosynthesis, periplasmic, MdoG C-terminal, score 2.2e-167 550538007238 Uncharacterized conserved protein [Function unknown]; Region: COG2353 550538007239 HMMPfam hit to PF04264, Lipid/polyisoprenoid-binding, YceI-like, score 3.6e-49 550538007240 Transcriptional regulators [Transcription]; Region: FadR; COG2186 550538007241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538007242 DNA-binding site [nucleotide binding]; DNA binding site 550538007243 FCD domain; Region: FCD; pfam07729 550538007244 HMMPfam hit to PF07729, GntR, C-terminal, score 3.6e-25 550538007245 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.2e-18 550538007246 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 550538007247 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 550538007248 putative NAD(P) binding site [chemical binding]; other site 550538007249 catalytic Zn binding site [ion binding]; other site 550538007250 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 5.4e-33 550538007251 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 4.8e-45 550538007252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538007253 D-galactonate transporter; Region: 2A0114; TIGR00893 550538007254 putative substrate translocation pore; other site 550538007255 12 probable transmembrane helices predicted for SG1501 by TMHMM2.0 at aa 25-47, 62-84, 91-113, 118-140, 161-183, 187-209, 259-281, 296-315, 328-350, 356-378, 391-413 and 423-442 550538007256 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.2e-63 550538007257 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 550538007258 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 550538007259 NADP binding site [chemical binding]; other site 550538007260 homodimer interface [polypeptide binding]; other site 550538007261 active site 550538007262 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.7e-33 550538007263 PS00061 Short-chain dehydrogenases/reductases family signature. 550538007264 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 550538007265 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 550538007266 metal binding site [ion binding]; metal-binding site 550538007267 substrate binding pocket [chemical binding]; other site 550538007268 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 3.4e-27 550538007269 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.2e-16 550538007270 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 550538007271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538007272 Coenzyme A binding pocket [chemical binding]; other site 550538007273 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.1e-20 550538007274 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538007275 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 550538007276 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538007277 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 6.7e-70 550538007278 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.3e-23 550538007279 PS00894 Bacterial regulatory proteins, deoR family signature. 550538007280 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 550538007281 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 550538007282 substrate binding site [chemical binding]; other site 550538007283 hexamer interface [polypeptide binding]; other site 550538007284 metal binding site [ion binding]; metal-binding site 550538007285 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 3.6e-84 550538007286 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 550538007287 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 550538007288 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538007289 active site 550538007290 phosphorylation site [posttranslational modification] 550538007291 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 9.4e-52 550538007292 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 550538007293 HMMPfam hit to PF03437, Photosystem I assembly BtpA, score 3.7e-144 550538007294 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 550538007295 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 550538007296 9 probable transmembrane helices predicted for SG1509 by TMHMM2.0 at aa 5-27, 32-54, 82-104, 125-147, 216-235, 242-264, 298-320, 349-371 and 408-430 550538007297 HMMPfam hit to PF03611, Phosphotransferase system, galactitol-specific IIC component, score 1.3e-194 550538007298 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 550538007299 active site 550538007300 P-loop; other site 550538007301 phosphorylation site [posttranslational modification] 550538007302 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 9e-24 550538007303 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 550538007304 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 550538007305 oligomer interface [polypeptide binding]; other site 550538007306 active site 550538007307 metal binding site [ion binding]; metal-binding site 550538007308 HMMPfam hit to PF05343, Peptidase M42, score 1.2e-139 550538007309 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 550538007310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538007311 Coenzyme A binding pocket [chemical binding]; other site 550538007312 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.1e-09 550538007313 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 550538007314 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 550538007315 putative trimer interface [polypeptide binding]; other site 550538007316 putative CoA binding site [chemical binding]; other site 550538007317 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 550538007318 putative trimer interface [polypeptide binding]; other site 550538007319 putative CoA binding site [chemical binding]; other site 550538007320 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 76 550538007321 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 8.3 550538007322 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 69 550538007323 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 67 550538007324 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 92 550538007325 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 67 550538007326 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 550538007327 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 550538007328 gating phenylalanine in ion channel; other site 550538007329 10 probable transmembrane helices predicted for SG1514 by TMHMM2.0 at aa 13-32, 47-69, 82-104, 108-130, 143-165, 169-188, 200-222, 237-254, 261-280 and 290-312 550538007330 HMMPfam hit to PF03595, C4-dicarboxylate transporter/malic acid transport protein, score 4.2e-82 550538007331 tellurite resistance protein TehB; Provisional; Region: PRK11207 550538007332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538007333 S-adenosylmethionine binding site [chemical binding]; other site 550538007334 HMMPfam hit to PF03848, Tellurite resistance methyltransferase, TehB, core, score 8.6e-150 550538007335 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 550538007336 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007337 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 550538007338 benzoate transporter; Region: benE; TIGR00843 550538007339 11 probable transmembrane helices predicted for SG1517 by TMHMM2.0 at aa 10-30, 43-65, 93-112, 119-138, 143-165, 172-194, 209-231, 252-274, 289-311, 318-340 and 360-382 550538007340 HMMPfam hit to PF03594, Benzoate membrane transport protein, score 4.6e-199 550538007341 PS00041 Bacterial regulatory proteins, araC family signature. 550538007342 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 550538007343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538007344 non-specific DNA binding site [nucleotide binding]; other site 550538007345 salt bridge; other site 550538007346 sequence-specific DNA binding site [nucleotide binding]; other site 550538007347 Cupin domain; Region: Cupin_2; pfam07883 550538007348 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.5e-15 550538007349 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 2.6e-07 550538007350 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 550538007351 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 550538007352 Peptidase family U32; Region: Peptidase_U32; pfam01136 550538007353 Collagenase; Region: DUF3656; pfam12392 550538007354 HMMPfam hit to PF01136, Peptidase U32, score 5.7e-97 550538007355 PS01276 Peptidase family U32 signature. 550538007356 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 550538007358 HMMPfam hit to PF06767, Sif, score 2.5e-27 550538007359 2 probable transmembrane helices predicted for SG1523 by TMHMM2.0 at aa 33-67 and 82-104 550538007360 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 550538007361 HMMPfam hit to PF01427, Peptidase M15D, vanX D-ala-D-ala dipeptidase, score 1.1e-40 550538007362 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 550538007363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538007364 DNA-binding site [nucleotide binding]; DNA binding site 550538007365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538007366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538007367 homodimer interface [polypeptide binding]; other site 550538007368 catalytic residue [active] 550538007369 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.2e-15 550538007370 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 7e-12 550538007371 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 550538007372 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 550538007373 tetrameric interface [polypeptide binding]; other site 550538007374 NAD binding site [chemical binding]; other site 550538007375 catalytic residues [active] 550538007376 substrate binding site [chemical binding]; other site 550538007377 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.9e-217 550538007378 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538007379 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 550538007380 2 probable transmembrane helices predicted for SG1527 by TMHMM2.0 at aa 33-55 and 62-84 550538007381 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 550538007382 this CDS carries a premature stop codn and has an internal inversion. The inverted section of this protein is represented by partial CDS SG1529A; HMMPfam hit to PF07520, Predicted virulence protein SrfB, score 0 550538007383 region within SG1531 that has undergone an inversion 550538007384 this CDS is part of SG1529, representing a fragment of this CDS that has undergone an inversion event; HMMPfam hit to PF07520, Predicted virulence protein SrfB, score 9.2e-212 550538007385 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 550538007386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 550538007387 5 probable transmembrane helices predicted for SG1534 by TMHMM2.0 at aa 5-25, 32-54, 69-88, 95-117 and 122-144 550538007388 HMMPfam hit to PF04657, Protein of unknown function DUF606, score 3.7e-50 550538007389 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 550538007390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 550538007391 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 5.3e-23 550538007392 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 550538007393 Prostaglandin dehydrogenases; Region: PGDH; cd05288 550538007394 NAD(P) binding site [chemical binding]; other site 550538007395 substrate binding site [chemical binding]; other site 550538007396 dimer interface [polypeptide binding]; other site 550538007397 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 4.2e-18 550538007398 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 550538007399 DNA-binding site [nucleotide binding]; DNA binding site 550538007400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 550538007401 FCD domain; Region: FCD; pfam07729 550538007402 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 6.1e-13 550538007403 HMMPfam hit to PF07729, GntR, C-terminal, score 2e-06 550538007405 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 8e-34 550538007406 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.7e-24 550538007408 remnant of a CDS encoding an intact lipoprotein in S. eneritidis PT4 550538007409 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 1.6e-18 550538007410 L-asparagine permease; Provisional; Region: PRK15049 550538007411 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.4e-178 550538007412 12 probable transmembrane helices predicted for SG1543 by TMHMM2.0 at aa 37-59, 64-86, 107-129, 144-166, 171-193, 218-240, 260-282, 302-324, 351-373, 377-399, 420-442 and 446-468 550538007413 PS00218 Amino acid permeases signature. 550538007414 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 550538007415 HMMPfam hit to PF00797, N-acetyltransferase, score 5.5e-119 550538007416 hypothetical protein; Provisional; Region: PRK10281 550538007417 HMMPfam hit to PF02567, Phenazine biosynthesis PhzC/PhzF protein, score 3.9e-118 550538007418 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 550538007419 HMMPfam hit to PF02665, Nitrate reductase, gamma subunit, score 1.1e-118 550538007420 5 probable transmembrane helices predicted for SG1547 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 128-150 and 185-207 550538007421 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 550538007422 HMMPfam hit to PF02613, Nitrate reductase, delta subunit, score 7.7e-85 550538007423 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 550538007424 PS00190 Cytochrome c family heme-binding site signature. 550538007425 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 550538007426 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 550538007427 [4Fe-4S] binding site [ion binding]; other site 550538007428 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538007429 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538007430 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538007431 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 550538007432 molybdopterin cofactor binding site; other site 550538007433 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 7.9e-26 550538007434 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 3.2e-143 550538007435 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538007436 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538007437 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 550538007438 12 probable transmembrane helices predicted for SG1551 by TMHMM2.0 at aa 36-58, 73-95, 102-121, 131-153, 174-196, 211-233, 254-276, 286-308, 313-335, 345-367, 401-418 and 433-455 550538007439 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.1e-13 550538007440 TetR family transcriptional regulator; Provisional; Region: PRK14996 550538007441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538007442 1 probable transmembrane helix predicted for SG1552 by TMHMM2.0 at aa 151-170 550538007443 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 4.9e-12 550538007444 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 550538007445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538007446 putative substrate translocation pore; other site 550538007447 14 probable transmembrane helices predicted for SG1553 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 132-154, 158-180, 193-212, 222-240, 261-283, 298-320, 322-344, 354-376, 389-411 and 468-490 550538007448 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.1e-48 550538007449 Uncharacterized conserved protein [Function unknown]; Region: COG3791 550538007450 HMMPfam hit to PF04828, Glutathione-dependent formaldehyde-activating, GFA, score 2.4e-18 550538007451 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 550538007452 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 550538007453 trimer interface [polypeptide binding]; other site 550538007454 eyelet of channel; other site 550538007455 HMMPfam hit to PF00267, Porin, Gram-negative type, score 1.1e-199 550538007456 PS00576 General diffusion Gram-negative porins signature. 550538007457 aromatic amino acid exporter; Provisional; Region: PRK11689 550538007458 9 probable transmembrane helices predicted for SG1556 by TMHMM2.0 at aa 15-34, 46-68, 72-94, 101-119, 129-151, 163-185, 190-212, 219-241 and 251-270 550538007459 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.1e-06 550538007460 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 550538007461 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 550538007462 [4Fe-4S] binding site [ion binding]; other site 550538007463 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538007464 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 550538007465 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 550538007466 molybdopterin cofactor binding site; other site 550538007467 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 9.8e-22 550538007468 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538007469 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.3e-33 550538007470 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 4.1e-14 550538007471 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538007472 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 550538007473 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 550538007474 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.1e-05 550538007475 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538007476 HMMPfam hit to PF09163, Formate dehydrogenase, transmembrane, score 5.9e-22 550538007477 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 550538007478 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 550538007479 4 probable transmembrane helices predicted for SG1559 by TMHMM2.0 at aa 13-35, 50-72, 112-134 and 149-171 550538007480 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 550538007481 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 550538007482 NAD binding site [chemical binding]; other site 550538007483 substrate binding site [chemical binding]; other site 550538007484 catalytic Zn binding site [ion binding]; other site 550538007485 tetramer interface [polypeptide binding]; other site 550538007486 structural Zn binding site [ion binding]; other site 550538007487 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 5.4e-36 550538007488 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 9e-45 550538007489 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538007490 PS00190 Cytochrome c family heme-binding site signature. 550538007491 malate dehydrogenase; Provisional; Region: PRK13529 550538007492 Malic enzyme, N-terminal domain; Region: malic; pfam00390 550538007493 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 550538007494 NAD(P) binding site [chemical binding]; other site 550538007495 HMMPfam hit to PF03949, Malic enzyme, NAD-binding, score 3.5e-142 550538007496 PS00331 Malic enzymes signature. 550538007497 HMMPfam hit to PF00390, Malic enzyme, N-terminal, score 1.6e-130 550538007498 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 550538007499 HMMPfam hit to PF08136, Ribosomal protein, S22, score 2.6e-38 550538007500 biofilm-dependent modulation protein; Provisional; Region: PRK11436 550538007501 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 550538007502 HMMPfam hit to PF02566, OsmC-like protein, score 5.2e-28 550538007503 acid-resistance protein; Provisional; Region: hdeB; PRK11566 550538007504 1 probable transmembrane helix predicted for SG1565 by TMHMM2.0 at aa 4-26 550538007505 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 550538007506 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007507 HMMPfam hit to PF06884, Protein of unknown function DUF1264, score 4.3e-142 550538007508 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 550538007509 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 550538007510 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 550538007511 catalytic site [active] 550538007512 active site 550538007513 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 550538007514 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 0.05 550538007515 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2.3e-14 550538007517 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2.2e-15 550538007518 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 550538007519 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 550538007520 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 550538007521 active site 550538007522 catalytic site [active] 550538007523 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 1.6e-30 550538007524 PS00018 EF-hand calcium-binding domain. 550538007525 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 4.4e-14 550538007526 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 550538007527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538007528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538007529 homodimer interface [polypeptide binding]; other site 550538007530 catalytic residue [active] 550538007531 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.2e-30 550538007532 remnant of a CDS that remains intact in S. enteritidis 550538007533 HMMPfam hit to PF03553, Na+/H+ antiporter NhaC, score 3.2e-24 550538007534 remnant of a CDS that remains intact in S. enteritidis 550538007535 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1e-06 550538007536 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4e-11 550538007538 HMMPfam hit to PF07377, Protein of unknown function DUF1493, score 6e-19 550538007539 remnant of a CDS that remanins intact in S. enteritidis; regulated by phoPQ-regulated protein 550538007540 deletion remnant of a CDS that remains intact in S. enteritidis 550538007541 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 8.3e-17 550538007542 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 550538007543 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 550538007544 putative NAD(P) binding site [chemical binding]; other site 550538007545 catalytic Zn binding site [ion binding]; other site 550538007546 structural Zn binding site [ion binding]; other site 550538007547 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 2.6e-46 550538007548 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 5.4e-37 550538007549 Transcriptional regulators [Transcription]; Region: FadR; COG2186 550538007550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538007551 DNA-binding site [nucleotide binding]; DNA binding site 550538007552 FCD domain; Region: FCD; pfam07729 550538007553 HMMPfam hit to PF07729, GntR, C-terminal, score 1.4e-36 550538007554 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 6.1e-23 550538007555 PS00043 Bacterial regulatory proteins, gntR family signature. 550538007556 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 550538007557 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 550538007558 active site 550538007559 HMMPfam hit to PF02275, Choloylglycine hydrolase, score 8.2e-22 550538007560 1 probable transmembrane helix predicted for SG1580 by TMHMM2.0 at aa 7-29 550538007561 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007562 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 550538007563 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 550538007564 HMMPfam hit to PF08425, NiFe dehydrogenase small subunit, N-terminal, score 9.4e-50 550538007565 1 probable transmembrane helix predicted for SG1581 by TMHMM2.0 at aa 21-43 550538007566 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 5e-25 550538007567 hydrogenase 1 large subunit; Provisional; Region: PRK10170 550538007568 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 550538007569 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, large subunit, score 0 550538007570 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 550538007571 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 550538007572 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 550538007573 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 2.4e-62 550538007574 PS00882 Nickel-dependent hydrogenases b-type cytochrome subunit signature 1. 550538007575 4 probable transmembrane helices predicted for SG1583 by TMHMM2.0 at aa 43-62, 82-104, 151-173 and 203-225 550538007576 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 550538007577 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 550538007578 putative substrate-binding site; other site 550538007579 nickel binding site [ion binding]; other site 550538007580 HMMPfam hit to PF01750, Peptidase A31, hydrogen uptake protein, score 1.8e-44 550538007581 HupF/HypC family; Region: HupF_HypC; cl00394 550538007582 HMMPfam hit to PF01455, Hydrogenase expression/formation protein (HUPF/HYPC), score 5.4e-15 550538007583 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 550538007584 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 550538007585 HMMPfam hit to PF07449, Hydrogenase-1 expression HyaE, score 5.1e-55 550538007586 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 550538007587 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 550538007588 Rubredoxin [Energy production and conversion]; Region: COG1773 550538007589 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 550538007590 iron binding site [ion binding]; other site 550538007591 HMMPfam hit to PF04809, HupH hydrogenase expression protein, C-terminal conserved region, score 4.9e-41 550538007592 HMMPfam hit to PF00301, Rubredoxin-type Fe(Cys)4 protein, score 3.8e-23 550538007593 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 550538007594 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007595 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 550538007596 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 550538007597 HMMPfam hit to PF01155, Hydrogenase expression/synthesis, HypA, score 2e-58 550538007598 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 550538007599 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 550538007600 eyelet of channel; other site 550538007601 trimer interface [polypeptide binding]; other site 550538007602 HMMPfam hit to PF00267, Porin, Gram-negative type, score 1.9e-164 550538007603 PS00576 General diffusion Gram-negative porins signature. 550538007604 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 550538007605 the sequence has been checked and is believed to be correct 550538007606 HMMPfam hit to PF05249, Protein of unknown function UPF0187, score 5.1e-171 550538007607 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 550538007608 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 550538007609 glutaminase; Provisional; Region: PRK00971 550538007610 HMMPfam hit to PF04960, Glutaminase, core, score 9.2e-202 550538007611 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 550538007612 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 550538007613 NAD(P) binding site [chemical binding]; other site 550538007614 catalytic residues [active] 550538007615 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 5.1e-166 550538007616 PS00070 Aldehyde dehydrogenases cysteine active site. 550538007617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538007618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538007619 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 550538007620 putative dimerization interface [polypeptide binding]; other site 550538007621 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.2e-16 550538007622 PS00044 Bacterial regulatory proteins, lysR family signature. 550538007623 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.9e-52 550538007624 putative arabinose transporter; Provisional; Region: PRK03545 550538007625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538007626 putative substrate translocation pore; other site 550538007627 12 probable transmembrane helices predicted for SG1597 by TMHMM2.0 at aa 12-34, 49-71, 80-99, 109-131, 138-160, 170-189, 210-229, 244-266, 273-295, 299-321, 333-352 and 362-384 550538007628 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 6.1e-47 550538007629 inner membrane protein; Provisional; Region: PRK10995 550538007630 HMMPfam hit to PF01914, Multiple antibiotic resistance (MarC)-related proteins, score 8.7e-95 550538007631 6 probable transmembrane helices predicted for SG1598 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 117-139, 154-176 and 196-217 550538007632 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 550538007633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 550538007634 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 3.4e-29 550538007635 PS00190 Cytochrome c family heme-binding site signature. 550538007636 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 550538007637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538007638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538007639 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.9e-13 550538007640 PS00041 Bacterial regulatory proteins, araC family signature. 550538007641 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.6e-10 550538007642 MarB protein; Region: MarB; pfam13999 550538007643 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 550538007644 EamA-like transporter family; Region: EamA; pfam00892 550538007645 10 probable transmembrane helices predicted for SG1602 by TMHMM2.0 at aa 7-24, 34-52, 59-81, 91-110, 117-136, 140-162, 174-196, 216-238, 245-264 and 268-290 550538007646 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3e-16 550538007647 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.1e-12 550538007648 putative transporter; Provisional; Region: PRK10054 550538007649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538007650 putative substrate translocation pore; other site 550538007651 12 probable transmembrane helices predicted for SG1603 by TMHMM2.0 at aa 12-34, 44-66, 75-94, 99-121, 133-155, 165-187, 207-226, 246-265, 272-294, 299-321, 334-356 and 360-382 550538007652 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.9e-32 550538007653 hypothetical protein; Provisional; Region: PRK10053 550538007654 HMMPfam hit to PF04076, Conserved hypothetical protein CHP00156, score 3e-62 550538007655 hypothetical protein; Validated; Region: PRK03657 550538007656 HMMPfam hit to PF02464, CinA, C-terminal, score 4.8e-62 550538007657 General stress protein [General function prediction only]; Region: GsiB; COG3729 550538007658 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 550538007659 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 550538007660 active site 550538007661 Zn binding site [ion binding]; other site 550538007662 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 6.6e-176 550538007663 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538007664 malonic semialdehyde reductase; Provisional; Region: PRK10538 550538007665 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 550538007666 putative NAD(P) binding site [chemical binding]; other site 550538007667 homodimer interface [polypeptide binding]; other site 550538007668 homotetramer interface [polypeptide binding]; other site 550538007669 active site 550538007670 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.1e-35 550538007671 PS00061 Short-chain dehydrogenases/reductases family signature. 550538007672 Transcriptional regulators [Transcription]; Region: GntR; COG1802 550538007673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538007674 DNA-binding site [nucleotide binding]; DNA binding site 550538007675 FCD domain; Region: FCD; pfam07729 550538007676 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 5.1e-21 550538007677 PS00043 Bacterial regulatory proteins, gntR family signature. 550538007678 HMMPfam hit to PF07729, GntR, C-terminal, score 4.4e-10 550538007679 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 550538007680 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007681 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 550538007682 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 550538007683 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 550538007684 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 6.2e-126 550538007685 PS00974 Mannitol dehydrogenases signature. 550538007686 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 3.1e-87 550538007688 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5.6e-23 550538007689 putative oxidoreductase; Provisional; Region: PRK10083 550538007690 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 550538007691 putative NAD(P) binding site [chemical binding]; other site 550538007692 catalytic Zn binding site [ion binding]; other site 550538007693 structural Zn binding site [ion binding]; other site 550538007694 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 7.2e-22 550538007695 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 4.2e-54 550538007696 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538007697 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 550538007698 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 550538007699 putative active site pocket [active] 550538007700 putative metal binding site [ion binding]; other site 550538007701 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 2.1e-16 550538007702 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 550538007703 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 2.2e-58 550538007704 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 550538007705 hypothetical protein; Provisional; Region: PRK02237 550538007706 HMMPfam hit to PF02694, Protein of unknown function UPF0060, score 1.1e-69 550538007707 4 probable transmembrane helices predicted for SG1616 by TMHMM2.0 at aa 7-26, 30-52, 59-78 and 83-105 550538007708 hypothetical protein; Provisional; Region: PRK13659 550538007709 HMMPfam hit to PF06932, Protein of unknown function DUF1283, score 3e-70 550538007710 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 550538007711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538007712 Coenzyme A binding pocket [chemical binding]; other site 550538007713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 550538007714 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.7e-20 550538007715 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 550538007716 HMMPfam hit to PF06788, Protein of unknown function UPF0257, score 2.3e-194 550538007717 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007718 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 550538007719 HMMPfam hit to PF06649, Protein of unknown function DUF1161, score 8e-45 550538007720 the sequence has been checked and is believed to be correct 550538007721 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 3.3e-130 550538007722 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 4.3e-35 550538007723 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 550538007724 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 550538007725 putative [Fe4-S4] binding site [ion binding]; other site 550538007726 putative molybdopterin cofactor binding site [chemical binding]; other site 550538007727 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 550538007728 putative molybdopterin cofactor binding site; other site 550538007729 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 1.3e-12 550538007730 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538007731 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 5.3e-124 550538007732 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.2e-34 550538007733 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 550538007734 4Fe-4S binding domain; Region: Fer4; pfam00037 550538007735 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.5e-07 550538007736 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538007737 PS00190 Cytochrome c family heme-binding site signature. 550538007738 PS00190 Cytochrome c family heme-binding site signature. 550538007739 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 550538007740 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 2.8e-144 550538007741 8 probable transmembrane helices predicted for SG1624 by TMHMM2.0 at aa 10-32, 44-66, 88-107, 114-136, 151-173, 180-202, 222-244 and 251-273 550538007742 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 550538007743 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 2.5e-59 550538007744 the sequence has been checked and is believed to be correct 550538007745 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.6e-20 550538007746 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 550538007747 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 3.1e-90 550538007748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538007749 dimer interface [polypeptide binding]; other site 550538007750 conserved gate region; other site 550538007751 ABC-ATPase subunit interface; other site 550538007752 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.2e-23 550538007753 5 probable transmembrane helices predicted for SG1628 by TMHMM2.0 at aa 22-44, 51-73, 78-100, 149-171 and 181-203 550538007754 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538007755 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 550538007756 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 550538007757 Walker A/P-loop; other site 550538007758 ATP binding site [chemical binding]; other site 550538007759 Q-loop/lid; other site 550538007760 ABC transporter signature motif; other site 550538007761 Walker B; other site 550538007762 D-loop; other site 550538007763 H-loop/switch region; other site 550538007764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 550538007765 HMMPfam hit to PF00005, ABC transporter related, score 5.3e-59 550538007766 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007767 PS00211 ABC transporters family signature. 550538007768 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 8.7e-16 550538007769 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 550538007770 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 550538007771 Cl- selectivity filter; other site 550538007772 Cl- binding residues [ion binding]; other site 550538007773 pore gating glutamate residue; other site 550538007774 dimer interface [polypeptide binding]; other site 550538007775 10 probable transmembrane helices predicted for SG1630 by TMHMM2.0 at aa 12-34, 66-83, 158-180, 185-207, 234-256, 271-293, 300-322, 332-354, 361-383 and 398-416 550538007776 HMMPfam hit to PF00654, Chloride channel, core, score 3.4e-17 550538007777 putative dithiobiotin synthetase; Provisional; Region: PRK12374 550538007778 AAA domain; Region: AAA_26; pfam13500 550538007779 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 4e-28 550538007780 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007781 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 550538007782 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 550538007783 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538007784 nucleotide binding site [chemical binding]; other site 550538007785 HMMPfam hit to PF00480, ROK, score 1.4e-35 550538007786 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 550538007787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538007788 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 550538007789 dimerization interface [polypeptide binding]; other site 550538007790 substrate binding pocket [chemical binding]; other site 550538007791 HMMPfam hit to PF03466, LysR, substrate-binding, score 3e-51 550538007792 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 7.1e-20 550538007793 PS00044 Bacterial regulatory proteins, lysR family signature. 550538007794 the sequence has been checked and is believed to be correct 550538007795 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.8e-43 550538007796 HMMPfam hit to PF06392, Acid shock, score 0.00032 550538007798 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 550538007799 Domain of unknown function DUF20; Region: UPF0118; pfam01594 550538007800 8 probable transmembrane helices predicted for SG1637 by TMHMM2.0 at aa 5-24, 29-51, 63-85, 144-166, 196-218, 222-244, 257-279 and 299-321 550538007801 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 2.4e-83 550538007802 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 550538007803 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 550538007804 HMMPfam hit to PF02233, NAD(P) transhydrogenase, beta subunit, score 0 550538007805 9 probable transmembrane helices predicted for SG1638 by TMHMM2.0 at aa 5-24, 33-50, 55-72, 85-107, 122-144, 164-181, 185-207, 214-236 and 240-259 550538007806 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 550538007807 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 550538007808 ligand binding site [chemical binding]; other site 550538007809 homodimer interface [polypeptide binding]; other site 550538007810 NAD(P) binding site [chemical binding]; other site 550538007811 trimer interface B [polypeptide binding]; other site 550538007812 trimer interface A [polypeptide binding]; other site 550538007813 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 550538007814 5 probable transmembrane helices predicted for SG1639 by TMHMM2.0 at aa 169-191, 402-419, 423-445, 452-471 and 476-498 550538007815 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal, score 4.9e-89 550538007816 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. 550538007817 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal, score 1.7e-75 550538007818 PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. 550538007819 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538007820 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538007821 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538007822 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 7.2e-11 550538007823 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 550538007824 Spore germination protein; Region: Spore_permease; cl17796 550538007825 13 probable transmembrane helices predicted for SG1641 by TMHMM2.0 at aa 5-27, 37-59, 90-112, 127-149, 156-178, 205-222, 235-257, 277-299, 332-351, 356-378, 385-403, 408-427 and 440-459 550538007826 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.00031 550538007827 GlpM protein; Region: GlpM; pfam06942 550538007828 HMMPfam hit to PF06942, GlpM, score 8.7e-78 550538007829 4 probable transmembrane helices predicted for SG1642 by TMHMM2.0 at aa 2-21, 25-47, 59-81 and 86-108 550538007830 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 550538007831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538007832 active site 550538007833 phosphorylation site [posttranslational modification] 550538007834 intermolecular recognition site; other site 550538007835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538007836 DNA binding site [nucleotide binding] 550538007837 HMMPfam hit to PF00072, Response regulator receiver, score 8.9e-21 550538007838 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.3e-17 550538007839 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 550538007840 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 550538007841 trimer interface [polypeptide binding]; other site 550538007842 eyelet of channel; other site 550538007843 1 probable transmembrane helix predicted for SG1644 by TMHMM2.0 at aa 5-22 550538007844 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 550538007845 HMMPfam hit to PF00267, Porin, Gram-negative type, score 5.5e-219 550538007846 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 550538007847 Amidohydrolase family; Region: Amidohydro_3; pfam07969 550538007848 active site 550538007849 HMMPfam hit to PF07969, Amidohydrolase 3, score 1.4e-92 550538007850 sensor protein RstB; Provisional; Region: PRK10604 550538007851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538007852 dimerization interface [polypeptide binding]; other site 550538007853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538007854 dimer interface [polypeptide binding]; other site 550538007855 phosphorylation site [posttranslational modification] 550538007856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538007857 ATP binding site [chemical binding]; other site 550538007858 Mg2+ binding site [ion binding]; other site 550538007859 G-X-G motif; other site 550538007860 2 probable transmembrane helices predicted for SG1646 by TMHMM2.0 at aa 5-27 and 139-156 550538007861 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.7e-08 550538007862 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.1e-11 550538007863 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.9e-35 550538007864 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 550538007865 HMMPfam hit to PF05472, DNA replication terminus site-binding protein, score 7.9e-226 550538007866 fumarate hydratase; Reviewed; Region: fumC; PRK00485 550538007867 Class II fumarases; Region: Fumarase_classII; cd01362 550538007868 active site 550538007869 tetramer interface [polypeptide binding]; other site 550538007870 HMMPfam hit to PF00206, Fumarate lyase, score 1.5e-196 550538007871 PS00163 Fumarate lyases signature. 550538007872 fumarate hydratase; Provisional; Region: PRK15389 550538007873 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 550538007874 Fumarase C-terminus; Region: Fumerase_C; pfam05683 550538007875 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 5.6e-118 550538007876 PS00163 Fumarate lyases signature. 550538007877 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 9.5e-139 550538007878 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 550538007879 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 550538007880 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 550538007881 HMMPfam hit to PF01238, Mannose-6-phosphate isomerase, type I, score 6.8e-186 550538007882 PS00965 Phosphomannose isomerase type I signature 1. 550538007883 PS00966 Phosphomannose isomerase type I signature 2. 550538007884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 550538007885 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 550538007886 HMMPfam hit to PF06097, Protein of unknown function DUF945, bacterial, score 1.6e-284 550538007887 1 probable transmembrane helix predicted for SG1652 by TMHMM2.0 at aa 5-24 550538007888 PS00017 ATP/GTP-binding site motif A (P-loop). 550538007889 the sequence has been checked and is believed to be correct 550538007890 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 3.2e-07 550538007891 the sequence has been checked and is believed to be correct 550538007892 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 550538007893 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 550538007894 active site 550538007895 purine riboside binding site [chemical binding]; other site 550538007896 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 2e-128 550538007897 PS00485 Adenosine and AMP deaminase signature. 550538007898 putative oxidoreductase; Provisional; Region: PRK11579 550538007899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 550538007900 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 550538007901 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 4.3e-25 550538007902 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 8.9e-44 550538007903 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 550538007904 HMMPfam hit to PF05321, Haemolysin expression modulating, score 1.8e-38 550538007905 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 550538007906 4 probable transmembrane helices predicted for SG1658 by TMHMM2.0 at aa 13-35, 55-77, 90-109 and 114-133 550538007907 electron transport complex protein RsxA; Provisional; Region: PRK05151 550538007908 HMMPfam hit to PF02508, RnfA-Nqr electron transport subunit, score 2e-115 550538007909 6 probable transmembrane helices predicted for SG1659 by TMHMM2.0 at aa 5-27, 42-64, 69-88, 103-125, 132-154 and 169-191 550538007910 electron transport complex protein RnfB; Provisional; Region: PRK05113 550538007911 Putative Fe-S cluster; Region: FeS; cl17515 550538007912 4Fe-4S binding domain; Region: Fer4; pfam00037 550538007913 1 probable transmembrane helix predicted for SG1660 by TMHMM2.0 at aa 4-26 550538007914 HMMPfam hit to PF04060, Fe-S cluster, score 8.8e-14 550538007915 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.4e-07 550538007916 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538007917 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.1e-05 550538007918 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538007919 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 550538007920 SLBB domain; Region: SLBB; pfam10531 550538007921 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 550538007922 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit, score 1.9e-100 550538007923 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00077 550538007924 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538007925 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00025 550538007926 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538007927 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 550538007928 HMMPfam hit to PF03116, NQR2 and RnfD, score 2.9e-188 550538007929 10 probable transmembrane helices predicted for SG1662 by TMHMM2.0 at aa 20-39, 43-62, 69-91, 95-117, 124-146, 214-236, 243-262, 272-294, 301-318 and 323-342 550538007930 electron transport complex protein RnfG; Validated; Region: PRK01908 550538007931 HMMPfam hit to PF04205, FMN-binding, score 1.9e-27 550538007932 electron transport complex RsxE subunit; Provisional; Region: PRK12405 550538007933 HMMPfam hit to PF02508, RnfA-Nqr electron transport subunit, score 3e-117 550538007934 5 probable transmembrane helices predicted for SG1664 by TMHMM2.0 at aa 34-56, 69-87, 91-113, 126-148 and 183-205 550538007935 endonuclease III; Provisional; Region: PRK10702 550538007936 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 550538007937 minor groove reading motif; other site 550538007938 helix-hairpin-helix signature motif; other site 550538007939 substrate binding pocket [chemical binding]; other site 550538007940 active site 550538007941 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 550538007942 HMMPfam hit to PF00730, HhH-GPD, score 1.5e-19 550538007943 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 4.3e-07 550538007944 PS01155 Endonuclease III family signature. 550538007945 PS00764 Endonuclease III iron-sulfur binding region signature. 550538007946 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 550538007947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538007948 putative substrate translocation pore; other site 550538007949 POT family; Region: PTR2; pfam00854 550538007950 14 probable transmembrane helices predicted for SG1666 by TMHMM2.0 at aa 22-44, 59-81, 90-107, 112-129, 150-172, 177-199, 220-239, 244-261, 274-296, 323-340, 353-371, 386-408, 415-437 and 457-479 550538007951 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 550538007952 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 1.7e-106 550538007953 PS00778 Histidine acid phosphatases active site signature. 550538007954 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 550538007955 glutathionine S-transferase; Provisional; Region: PRK10542 550538007956 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 550538007957 C-terminal domain interface [polypeptide binding]; other site 550538007958 GSH binding site (G-site) [chemical binding]; other site 550538007959 dimer interface [polypeptide binding]; other site 550538007960 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 550538007961 dimer interface [polypeptide binding]; other site 550538007962 substrate binding pocket (H-site) [chemical binding]; other site 550538007963 N-terminal domain interface [polypeptide binding]; other site 550538007964 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 9.4e-09 550538007965 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 4.5e-19 550538007966 pyridoxamine kinase; Validated; Region: PRK05756 550538007967 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 550538007968 dimer interface [polypeptide binding]; other site 550538007969 pyridoxal binding site [chemical binding]; other site 550538007970 ATP binding site [chemical binding]; other site 550538007971 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.4e-06 550538007972 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 550538007973 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 550538007974 active site 550538007975 HIGH motif; other site 550538007976 dimer interface [polypeptide binding]; other site 550538007977 KMSKS motif; other site 550538007978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538007979 RNA binding surface [nucleotide binding]; other site 550538007980 HMMPfam hit to PF01479, RNA-binding S4, score 9.1e-05 550538007981 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 6.3e-137 550538007982 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538007983 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 550538007984 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 550538007985 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 550538007986 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase-related, FMN-binding core, score 9.5e-32 550538007987 lysozyme inhibitor; Provisional; Region: PRK11372 550538007988 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 550538007989 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007990 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 550538007991 HMMPfam hit to PF03702, Protein of unknown function UPF0075, score 2e-243 550538007992 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 550538007993 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538007994 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 4.5e-10 550538007995 transcriptional regulator SlyA; Provisional; Region: PRK03573 550538007996 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 550538007997 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 6e-24 550538007998 PS01117 Bacterial regulatory proteins, marR family signature. 550538007999 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 550538008000 HMMPfam hit to PF07869, Protein of unknown function DUF1656, score 2.2e-26 550538008001 2 probable transmembrane helices predicted for SG1675 by TMHMM2.0 at aa 18-40 and 53-75 550538008002 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 550538008003 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538008004 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538008005 1 probable transmembrane helix predicted for SG1676 by TMHMM2.0 at aa 20-42 550538008006 HMMPfam hit to PF00529, Secretion protein HlyD, score 6.7e-48 550538008007 Fusaric acid resistance protein family; Region: FUSC; pfam04632 550538008008 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 550538008009 12 probable transmembrane helices predicted for SG1677 by TMHMM2.0 at aa 23-41, 46-65, 72-90, 94-113, 120-142, 157-179, 362-381, 385-404, 411-433, 438-455, 462-481 and 496-515 550538008010 PS00435 Peroxidases proximal heme-ligand signature. 550538008011 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved region, score 2.1e-45 550538008012 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 550538008013 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 550538008014 E-class dimer interface [polypeptide binding]; other site 550538008015 P-class dimer interface [polypeptide binding]; other site 550538008016 active site 550538008017 Cu2+ binding site [ion binding]; other site 550538008018 Zn2+ binding site [ion binding]; other site 550538008019 HMMPfam hit to PF00080, Superoxide dismutase, copper/zinc binding, score 3.1e-28 550538008020 PS00332 Copper/Zinc superoxide dismutase signature 2. 550538008021 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008022 the sequence has been checked and is believed to be correct 550538008023 HMMPfam hit to PF00248, Aldo/keto reductase, score 5.5e-69 550538008024 Predicted Fe-S protein [General function prediction only]; Region: COG3313 550538008025 HMMPfam hit to PF06945, Protein of unknown function DUF1289, score 7e-25 550538008026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 550538008027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538008028 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 3.3e-12 550538008029 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 550538008030 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 550538008031 FMN binding site [chemical binding]; other site 550538008032 active site 550538008033 substrate binding site [chemical binding]; other site 550538008034 catalytic residue [active] 550538008035 HMMPfam hit to PF00724, NADH:flavin oxidoreductase/NADH oxidase, N-terminal, score 4.3e-108 550538008036 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538008037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 550538008038 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 550538008039 dimer interface [polypeptide binding]; other site 550538008040 active site 550538008041 metal binding site [ion binding]; metal-binding site 550538008042 glutathione binding site [chemical binding]; other site 550538008043 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 8.4e-42 550538008044 PS00934 Glyoxalase I signature 1. 550538008045 PS00935 Glyoxalase I signature 2. 550538008046 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 550538008047 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 550538008048 dimer interface [polypeptide binding]; other site 550538008049 catalytic site [active] 550538008050 putative active site [active] 550538008051 putative substrate binding site [chemical binding]; other site 550538008052 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 2.4e-35 550538008053 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 550538008054 putative GSH binding site [chemical binding]; other site 550538008055 catalytic residues [active] 550538008056 HMMPfam hit to PF00462, Glutaredoxin, score 9.6e-28 550538008057 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 550538008058 NlpC/P60 family; Region: NLPC_P60; pfam00877 550538008059 HMMPfam hit to PF00877, NLP/P60, score 2.1e-56 550538008060 superoxide dismutase; Provisional; Region: PRK10543 550538008061 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 550538008062 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 550538008063 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 3e-53 550538008064 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008065 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 4.6e-83 550538008066 PS00088 Manganese and iron superoxide dismutases signature. 550538008067 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 550538008068 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538008069 DNA binding site [nucleotide binding] 550538008070 domain linker motif; other site 550538008071 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 550538008072 dimerization interface [polypeptide binding]; other site 550538008073 ligand binding site [chemical binding]; other site 550538008074 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.6e-12 550538008075 PS00356 Bacterial regulatory proteins, lacI family signature. 550538008076 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.2e-25 550538008077 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 550538008078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538008079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538008080 dimerization interface [polypeptide binding]; other site 550538008081 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.5e-28 550538008082 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.2e-19 550538008083 PS00044 Bacterial regulatory proteins, lysR family signature. 550538008084 putative transporter; Provisional; Region: PRK11043 550538008085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538008086 putative substrate translocation pore; other site 550538008087 11 probable transmembrane helices predicted for SG1690 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 132-154, 159-178, 208-230, 235-257, 270-292, 296-318 and 339-361 550538008088 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.1e-53 550538008089 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 550538008090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538008091 S-adenosylmethionine binding site [chemical binding]; other site 550538008092 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid synthase, score 2.4e-165 550538008093 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 550538008094 Lumazine binding domain; Region: Lum_binding; pfam00677 550538008095 Lumazine binding domain; Region: Lum_binding; pfam00677 550538008096 HMMPfam hit to PF00677, Lumazine-binding protein, score 4.8e-44 550538008097 HMMPfam hit to PF00677, Lumazine-binding protein, score 1e-44 550538008098 PS00693 Riboflavin synthase alpha chain family signature. 550538008099 multidrug efflux protein; Reviewed; Region: PRK01766 550538008100 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 550538008101 cation binding site [ion binding]; other site 550538008102 12 probable transmembrane helices predicted for SG1693 by TMHMM2.0 at aa 12-34, 44-66, 91-113, 128-147, 160-180, 190-212, 241-263, 278-300, 313-335, 350-367, 387-409 and 419-438 550538008103 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 9.9e-49 550538008104 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.6e-47 550538008105 Salmonella Pathogenicity Island 2 550538008106 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 550538008107 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 550538008108 HMMPfam hit to PF01312, Type III secretion exporter, score 6.7e-189 550538008109 4 probable transmembrane helices predicted for SG1694 by TMHMM2.0 at aa 21-43, 86-108, 146-168 and 178-200 550538008110 type III secretion system protein SsaT; Provisional; Region: PRK15349 550538008111 HMMPfam hit to PF01311, Type III secretion system inner membrane R protein, score 6.8e-106 550538008112 6 probable transmembrane helices predicted for SG1695 by TMHMM2.0 at aa 7-29, 34-56, 68-90, 129-151, 180-202 and 224-243 550538008113 type III secretion system protein SsaS; Provisional; Region: PRK15350 550538008114 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 2.3e-39 550538008115 2 probable transmembrane helices predicted for SG1696 by TMHMM2.0 at aa 13-35 and 55-77 550538008116 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 550538008117 4 probable transmembrane helices predicted for SG1697 by TMHMM2.0 at aa 10-31, 52-74, 154-176 and 189-211 550538008118 HMMPfam hit to PF00813, Type III secretion system inner membrane P protein, score 1.3e-118 550538008119 PS01061 Flagella transport protein fliP family signature 2. 550538008120 PS01060 Flagella transport protein fliP family signature 1. 550538008121 type III secretion system protein SsaQ; Validated; Region: PRK08035 550538008122 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 550538008123 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 3.6e-29 550538008124 type III secretion system protein SsaP; Provisional; Region: PRK15351 550538008125 type III secretion system protein SsaO; Provisional; Region: PRK15352 550538008126 type III secretion system ATPase SsaN; Validated; Region: PRK07594 550538008127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 550538008128 Walker A motif; other site 550538008129 ATP binding site [chemical binding]; other site 550538008130 Walker B motif; other site 550538008131 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 1.2e-117 550538008132 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 550538008133 FHIPEP family; Region: FHIPEP; pfam00771 550538008134 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 0 550538008135 6 probable transmembrane helices predicted for SG1702 by TMHMM2.0 at aa 24-41, 48-67, 115-137, 206-228, 248-270 and 291-313 550538008136 PS00994 Bacterial export FHIPEP family signature. 550538008137 type III secretion system protein SsaM; Provisional; Region: PRK15353 550538008138 type III secretion system protein SsaL; Provisional; Region: PRK15345 550538008139 HrpJ-like domain; Region: HrpJ; pfam07201 550538008140 TyeA; Region: TyeA; cl07611 550538008141 HMMPfam hit to PF07018, SepL/SsaL, score 2.5e-246 550538008142 type III secretion system protein SsaK; Provisional; Region: PRK15354 550538008143 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 550538008144 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 550538008145 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 550538008146 1 probable transmembrane helix predicted for SG1707 by TMHMM2.0 at aa 223-245 550538008147 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 4.2e-90 550538008148 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008149 type III secretion system protein SsaI; Provisional; Region: PRK15355 550538008150 type III secretion system protein SsaH; Provisional; Region: PRK15356 550538008151 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 550538008152 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 550538008153 2 probable transmembrane helices predicted for SG1711 by TMHMM2.0 at aa 65-87 and 97-116 550538008154 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 550538008155 2 probable transmembrane helices predicted for SG1712 by TMHMM2.0 at aa 64-86 and 90-112 550538008156 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 550538008157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 550538008158 TPR motif; other site 550538008159 binding surface 550538008160 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 550538008161 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 550538008162 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 550538008163 HMMPfam hit to PF04888, Secretion system effector C (SseC) like protein, score 6.5e-285 550538008164 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 550538008165 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.00011 550538008166 HMMPfam hit to PF07720, Tetratricopeptide TPR-3, score 0.0016 550538008167 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 550538008168 HMMPfam hit to PF03433, EspA-like protein, score 2.9e-134 550538008169 type III secretion system chaperone SseA; Provisional; Region: PRK15365 550538008170 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 550538008171 type III secretion system protein SsaD; Provisional; Region: PRK15367 550538008172 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 550538008173 1 probable transmembrane helix predicted for SG1721 by TMHMM2.0 at aa 117-139 550538008174 outer membrane secretin SsaC; Provisional; Region: PRK15346 550538008175 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 550538008176 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 550538008177 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 2e-72 550538008178 PS00875 Bacterial type II secretion system protein D signature. 550538008179 HMMPfam hit to PF03958, NolW-like, score 5.9e-12 550538008180 HMMPfam hit to PF03958, NolW-like, score 2.2e-10 550538008181 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 550538008182 two component system sensor kinase SsrA; Provisional; Region: PRK15347 550538008183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538008184 dimerization interface [polypeptide binding]; other site 550538008185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538008186 dimer interface [polypeptide binding]; other site 550538008187 phosphorylation site [posttranslational modification] 550538008188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538008189 ATP binding site [chemical binding]; other site 550538008190 Mg2+ binding site [ion binding]; other site 550538008191 G-X-G motif; other site 550538008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538008193 active site 550538008194 phosphorylation site [posttranslational modification] 550538008195 intermolecular recognition site; other site 550538008196 dimerization interface [polypeptide binding]; other site 550538008197 1 probable transmembrane helix predicted for SG1724 by TMHMM2.0 at aa 20-42 550538008198 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3.2e-11 550538008199 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 7.6e-21 550538008200 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.2e-38 550538008201 HMMPfam hit to PF00072, Response regulator receiver, score 2.3e-22 550538008202 two component system sensor kinase SsrB; Provisional; Region: PRK15369 550538008203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538008204 active site 550538008205 phosphorylation site [posttranslational modification] 550538008206 intermolecular recognition site; other site 550538008207 dimerization interface [polypeptide binding]; other site 550538008208 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538008209 DNA binding residues [nucleotide binding] 550538008210 dimerization interface [polypeptide binding]; other site 550538008211 HMMPfam hit to PF00072, Response regulator receiver, score 6.9e-31 550538008212 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 8.2e-18 550538008213 PS00622 Bacterial regulatory proteins, luxR family signature. 550538008214 transcriptional regulator MirA; Provisional; Region: PRK15043 550538008215 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 550538008216 DNA binding residues [nucleotide binding] 550538008217 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 6.9e-14 550538008218 PS00552 Bacterial regulatory proteins, merR family signature. 550538008219 Uncharacterized conserved protein [Function unknown]; Region: COG1683 550538008220 Uncharacterized conserved protein [Function unknown]; Region: COG3272 550538008221 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 550538008222 HMMPfam hit to PF04463, Protein of unknown function DUF523, score 1.3e-74 550538008223 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538008224 HMMPfam hit to PF08349, Protein of unknown function DUF1722, score 5.1e-68 550538008225 hypothetical protein; Provisional; Region: PRK10292 550538008226 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 550538008227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538008228 active site 550538008229 phosphorylation site [posttranslational modification] 550538008230 intermolecular recognition site; other site 550538008231 dimerization interface [polypeptide binding]; other site 550538008232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538008233 DNA binding residues [nucleotide binding] 550538008234 dimerization interface [polypeptide binding]; other site 550538008235 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.2e-21 550538008236 PS00622 Bacterial regulatory proteins, luxR family signature. 550538008237 HMMPfam hit to PF00072, Response regulator receiver, score 2.1e-24 550538008238 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 550538008239 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 550538008240 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 550538008241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538008242 dimer interface [polypeptide binding]; other site 550538008243 phosphorylation site [posttranslational modification] 550538008244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538008245 ATP binding site [chemical binding]; other site 550538008246 Mg2+ binding site [ion binding]; other site 550538008247 G-X-G motif; other site 550538008248 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.9e-25 550538008249 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 8.3e-06 550538008250 2 probable transmembrane helices predicted for SG1730 by TMHMM2.0 at aa 9-31 and 305-327 550538008251 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008253 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0072 550538008254 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 6e-07 550538008256 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 2.2e-99 550538008257 tetrathionate reductase subunit A; Provisional; Region: PRK14991 550538008258 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 550538008259 putative [Fe4-S4] binding site [ion binding]; other site 550538008260 putative molybdopterin cofactor binding site [chemical binding]; other site 550538008261 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 550538008262 putative molybdopterin cofactor binding site; other site 550538008263 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 4.6e-06 550538008264 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.4e-05 550538008265 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.9e-10 550538008266 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538008267 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538008268 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538008269 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 550538008270 substrate binding site [chemical binding]; other site 550538008271 dimer interface [polypeptide binding]; other site 550538008272 ATP binding site [chemical binding]; other site 550538008273 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2.8e-12 550538008274 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 3.5e-83 550538008275 PS00583 pfkB family of carbohydrate kinases signature 1. 550538008276 the sequence has been checked and is believed to be correct 550538008277 HMMPfam hit to PF07090, Protein of unknown function DUF1355, score 3.1e-201 550538008278 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 550538008279 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 5.5e-16 550538008280 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 550538008281 13 probable transmembrane helices predicted for SG1738 by TMHMM2.0 at aa 10-32, 39-61, 71-93, 95-114, 119-138, 147-169, 184-206, 227-249, 273-295, 330-347, 357-379, 386-405 and 409-428 550538008282 HMMPfam hit to PF00324, Amino acid permease-associated region, score 3.2e-08 550538008283 pyruvate kinase; Provisional; Region: PRK09206 550538008284 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 550538008285 active site 550538008286 domain interfaces; other site 550538008287 HMMPfam hit to PF00224, Pyruvate kinase, barrel, score 4.5e-196 550538008288 PS00110 Pyruvate kinase active site signature. 550538008289 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta, score 8.2e-31 550538008290 murein lipoprotein; Provisional; Region: PRK15396 550538008291 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008292 HMMPfam hit to PF04728, LPP motif, score 0.012 550538008293 HMMPfam hit to PF04728, LPP motif, score 0.013 550538008294 murein lipoprotein; Provisional; Region: PRK15396 550538008295 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008296 HMMPfam hit to PF04728, LPP motif, score 0.012 550538008297 the sequence has been checked and is believed to be correct 550538008298 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 1e-60 550538008299 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 1.2e-08 550538008300 cysteine desufuration protein SufE; Provisional; Region: PRK09296 550538008301 HMMPfam hit to PF02657, Fe-S metabolism associated SufE, score 6.3e-64 550538008302 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 550538008303 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 550538008304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538008305 catalytic residue [active] 550538008306 HMMPfam hit to PF00266, Aminotransferase, class V, score 1e-230 550538008307 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 550538008308 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 550538008309 FeS assembly protein SufD; Region: sufD; TIGR01981 550538008310 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 1.4e-93 550538008311 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 550538008312 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 550538008313 Walker A/P-loop; other site 550538008314 ATP binding site [chemical binding]; other site 550538008315 Q-loop/lid; other site 550538008316 ABC transporter signature motif; other site 550538008317 Walker B; other site 550538008318 D-loop; other site 550538008319 H-loop/switch region; other site 550538008320 HMMPfam hit to PF00005, ABC transporter related, score 6.1e-32 550538008321 PS00211 ABC transporters family signature. 550538008322 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008323 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 550538008324 putative ABC transporter; Region: ycf24; CHL00085 550538008325 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 4.6e-148 550538008326 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 550538008327 PS01152 Hypothetical hesB/yadR/yfhF family signature. 550538008328 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 2e-35 550538008329 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 550538008330 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 550538008331 11 probable transmembrane helices predicted for SG1749 by TMHMM2.0 at aa 4-19, 32-51, 66-88, 101-123, 170-192, 220-242, 252-274, 286-308, 336-353, 358-380 and 384-406 550538008332 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 3.1e-59 550538008333 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 550538008334 CoenzymeA binding site [chemical binding]; other site 550538008335 subunit interaction site [polypeptide binding]; other site 550538008336 PHB binding site; other site 550538008337 HMMPfam hit to PF03061, Thioesterase superfamily, score 6.7e-19 550538008338 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 550538008339 FAD binding domain; Region: FAD_binding_4; pfam01565 550538008340 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 550538008341 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538008342 HMMPfam hit to PF02913, FAD linked oxidase, C-terminal, score 1.9e-73 550538008343 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538008344 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 9.2e-49 550538008345 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008346 putative inner membrane protein; Provisional; Region: PRK10983 550538008347 Domain of unknown function DUF20; Region: UPF0118; pfam01594 550538008348 8 probable transmembrane helices predicted for SG1753 by TMHMM2.0 at aa 13-32, 36-53, 65-87, 160-179, 216-238, 248-270, 277-299 and 314-336 550538008349 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 5.5e-69 550538008350 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008351 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 550538008352 HMMPfam hit to PF08965, Protein of unknown function DUF1870, score 7.9e-95 550538008353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538008354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538008355 putative substrate translocation pore; other site 550538008356 12 probable transmembrane helices predicted for SG1755 by TMHMM2.0 at aa 7-29, 39-61, 74-91, 95-112, 133-155, 159-181, 211-233, 248-270, 277-299, 303-325, 337-359 and 364-386 550538008357 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.1e-32 550538008358 PS00216 Sugar transport proteins signature 1. 550538008359 PS00043 Bacterial regulatory proteins, gntR family signature. 550538008360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538008361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538008362 putative substrate translocation pore; other site 550538008363 12 probable transmembrane helices predicted for SG1756 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 101-118, 138-160, 164-186, 212-234, 254-273, 280-298, 308-330, 343-365 and 370-392 550538008364 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 7.4e-33 550538008365 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 550538008366 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 550538008367 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 550538008368 shikimate binding site; other site 550538008369 NAD(P) binding site [chemical binding]; other site 550538008370 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate binding, N-terminal, score 5.6e-39 550538008371 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 6.7e-26 550538008372 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008373 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 550538008374 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 550538008375 active site 550538008376 catalytic residue [active] 550538008377 dimer interface [polypeptide binding]; other site 550538008378 HMMPfam hit to PF01487, Dehydroquinase class I, score 3.3e-111 550538008379 PS01028 Dehydroquinase class I active site. 550538008380 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 550538008381 Coenzyme A transferase; Region: CoA_trans; smart00882 550538008382 Coenzyme A transferase; Region: CoA_trans; cl17247 550538008383 HMMPfam hit to PF01144, Coenzyme A transferase, score 3.4e-66 550538008384 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 550538008385 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 550538008386 active site 550538008387 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 6.6e-18 550538008388 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase/oxidase, central region, score 5.6e-14 550538008389 PS00072 Acyl-CoA dehydrogenases signature 1. 550538008390 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 8.5e-57 550538008391 PS00073 Acyl-CoA dehydrogenases signature 2. 550538008392 Cupin domain; Region: Cupin_2; pfam07883 550538008393 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 550538008394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538008395 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.2e-06 550538008396 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9.1e-05 550538008397 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.3e-10 550538008398 the sequence has been checked and is believed to be correct 550538008399 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/beta-subunit, N-terminal, score 2.7e-46 550538008400 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 550538008401 Electron transfer flavoprotein domain; Region: ETF; smart00893 550538008402 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 550538008403 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/beta-subunit, N-terminal, score 3e-31 550538008404 HMMPfam hit to PF00766, Electron transfer flavoprotein, alpha subunit, C-terminal, score 4.4e-41 550538008405 PS00696 Electron transfer flavoprotein alpha-subunit signature. 550538008406 oxidoreductase; Provisional; Region: PRK10015 550538008407 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.8e-12 550538008408 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 550538008409 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538008410 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 550538008411 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 550538008412 acyl-activating enzyme (AAE) consensus motif; other site 550538008413 putative AMP binding site [chemical binding]; other site 550538008414 putative active site [active] 550538008415 putative CoA binding site [chemical binding]; other site 550538008416 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 7.1e-123 550538008417 PS00455 AMP-binding domain signature. 550538008418 phosphoenolpyruvate synthase; Validated; Region: PRK06464 550538008419 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 550538008420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 550538008421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 550538008422 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 7e-63 550538008423 PS00742 PEP-utilizing enzymes signature 2. 550538008424 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 2.6e-42 550538008425 PS00370 PEP-utilizing enzymes phosphorylation site signature. 550538008426 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyruvate-binding, score 1.3e-172 550538008427 PEP synthetase regulatory protein; Provisional; Region: PRK05339 550538008428 HMMPfam hit to PF03618, Protein of unknown function DUF299, score 1.4e-162 550538008429 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008430 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 550538008431 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 550538008432 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 1e-172 550538008433 hypothetical protein; Provisional; Region: PRK10183 550538008435 HMMPfam hit to PF02696, Protein of unknown function UPF0061, score 7.5e-243 550538008436 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 550538008437 NlpC/P60 family; Region: NLPC_P60; pfam00877 550538008438 HMMPfam hit to PF00877, NLP/P60, score 2.5e-48 550538008439 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008440 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 550538008441 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 550538008442 Walker A/P-loop; other site 550538008443 ATP binding site [chemical binding]; other site 550538008444 Q-loop/lid; other site 550538008445 ABC transporter signature motif; other site 550538008446 Walker B; other site 550538008447 D-loop; other site 550538008448 H-loop/switch region; other site 550538008449 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-36 550538008450 PS00211 ABC transporters family signature. 550538008451 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008452 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 550538008453 catalytic residues [active] 550538008454 dimer interface [polypeptide binding]; other site 550538008455 HMMPfam hit to PF00255, Glutathione peroxidase, score 4.3e-67 550538008456 PS00763 Glutathione peroxidases signature 2. 550538008457 PS00460 Glutathione peroxidases selenocysteine active site. 550538008458 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 550538008459 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538008460 ABC-ATPase subunit interface; other site 550538008461 dimer interface [polypeptide binding]; other site 550538008462 putative PBP binding regions; other site 550538008463 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 1.3e-133 550538008464 9 probable transmembrane helices predicted for SG1777 by TMHMM2.0 at aa 17-39, 59-81, 88-107, 111-133, 146-168, 188-205, 242-264, 274-296 and 303-322 550538008465 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 550538008466 IHF dimer interface [polypeptide binding]; other site 550538008467 IHF - DNA interface [nucleotide binding]; other site 550538008468 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 4.7e-47 550538008469 PS00045 Bacterial histone-like DNA-binding proteins signature. 550538008470 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 550538008471 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 550538008472 putative tRNA-binding site [nucleotide binding]; other site 550538008473 B3/4 domain; Region: B3_4; pfam03483 550538008474 tRNA synthetase B5 domain; Region: B5; smart00874 550538008475 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 550538008476 dimer interface [polypeptide binding]; other site 550538008477 motif 1; other site 550538008478 motif 3; other site 550538008479 motif 2; other site 550538008480 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 550538008481 HMMPfam hit to PF03147, Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding, score 1.7e-47 550538008482 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538008483 HMMPfam hit to PF03484, tRNA synthetase, B5, score 4.1e-31 550538008484 HMMPfam hit to PF03483, B3/4, score 1.3e-112 550538008485 HMMPfam hit to PF01588, tRNA-binding region, score 4.7e-45 550538008486 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 550538008487 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 550538008488 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 550538008489 dimer interface [polypeptide binding]; other site 550538008490 motif 1; other site 550538008491 active site 550538008492 motif 2; other site 550538008493 motif 3; other site 550538008494 HMMPfam hit to PF01409, Phenylalanyl-tRNA synthetase, class IIc, score 3.4e-169 550538008495 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538008496 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538008497 HMMPfam hit to PF02912, Phenylalanyl-tRNA synthetase, class II, N-terminal, score 1.2e-39 550538008498 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 550538008499 23S rRNA binding site [nucleotide binding]; other site 550538008500 L21 binding site [polypeptide binding]; other site 550538008501 L13 binding site [polypeptide binding]; other site 550538008502 HMMPfam hit to PF00453, Ribosomal protein L20, score 2.9e-69 550538008503 PS00937 Ribosomal protein L20 signature. 550538008504 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 550538008505 HMMPfam hit to PF01632, Ribosomal protein L35, score 1.2e-32 550538008506 PS00936 Ribosomal protein L35 signature. 550538008507 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 550538008508 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 550538008509 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 550538008510 HMMPfam hit to PF00707, Initiation factor 3, score 2.8e-55 550538008511 HMMPfam hit to PF05198, Initiation factor 3, score 1.5e-19 550538008512 PS00938 Initiation factor 3 signature. 550538008513 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 550538008514 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 550538008515 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 550538008516 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 550538008517 active site 550538008518 dimer interface [polypeptide binding]; other site 550538008519 motif 1; other site 550538008520 motif 2; other site 550538008521 motif 3; other site 550538008522 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 550538008523 anticodon binding site; other site 550538008524 HMMPfam hit to PF03129, Anticodon-binding, score 6.1e-33 550538008525 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538008526 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 2.1e-64 550538008527 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538008528 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 4.1e-24 550538008529 HMMPfam hit to PF02824, TGS, score 5.1e-16 550538008530 11 probable transmembrane helices predicted for SG1785 by TMHMM2.0 at aa 4-24, 31-53, 63-82, 102-121, 141-163, 168-185, 190-204, 211-233, 321-343, 355-377 and 381-403 550538008531 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 550538008532 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 550538008533 active site 550538008534 substrate binding site [chemical binding]; other site 550538008535 Mg2+ binding site [ion binding]; other site 550538008536 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 6.5e-57 550538008537 PS01070 DNA/RNA non-specific endonucleases active site. 550538008538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 550538008539 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 550538008540 HMMPfam hit to PF04338, Protein of unknown function DUF481, score 1.6e-115 550538008541 1 probable transmembrane helix predicted for SG1789 by TMHMM2.0 at aa 7-24 550538008542 6-phosphofructokinase 2; Provisional; Region: PRK10294 550538008543 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 550538008544 putative substrate binding site [chemical binding]; other site 550538008545 putative ATP binding site [chemical binding]; other site 550538008546 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 9.7e-74 550538008547 PS00583 pfkB family of carbohydrate kinases signature 1. 550538008548 PS00584 pfkB family of carbohydrate kinases signature 2. 550538008549 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 550538008550 Phosphotransferase enzyme family; Region: APH; pfam01636 550538008551 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 550538008552 active site 550538008553 ATP binding site [chemical binding]; other site 550538008554 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 550538008555 HMMPfam hit to PF03881, Fructosamine kinase, score 2.2e-215 550538008556 YniB-like protein; Region: YniB; pfam14002 550538008557 3 probable transmembrane helices predicted for SG1793 by TMHMM2.0 at aa 16-38, 79-101 and 150-172 550538008558 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 550538008559 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 550538008560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538008561 motif II; other site 550538008562 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.1e-32 550538008563 inner membrane protein; Provisional; Region: PRK11648 550538008564 HMMPfam hit to PF04307, Protein of unknown function DUF457, transmembrane, score 2.2e-40 550538008565 2 probable transmembrane helices predicted for SG1795 by TMHMM2.0 at aa 72-94 and 109-131 550538008566 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 550538008567 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 550538008568 9 probable transmembrane helices predicted for SG1796 by TMHMM2.0 at aa 5-22, 34-51, 71-93, 105-127, 180-202, 260-282, 340-362, 369-391 and 395-417 550538008569 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 1.1e-111 550538008570 cell division modulator; Provisional; Region: PRK10113 550538008571 hydroperoxidase II; Provisional; Region: katE; PRK11249 550538008572 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 550538008573 tetramer interface [polypeptide binding]; other site 550538008574 heme binding pocket [chemical binding]; other site 550538008575 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 550538008576 domain interactions; other site 550538008577 HMMPfam hit to PF00199, Catalase, N-terminal, score 4.8e-282 550538008578 PS00438 Catalase proximal active site signature. 550538008579 PS00437 Catalase proximal heme-ligand signature. 550538008580 HMMPfam hit to PF06628, Catalase-related, score 4.1e-32 550538008581 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 550538008582 putative active site [active] 550538008583 YdjC motif; other site 550538008584 Mg binding site [ion binding]; other site 550538008585 putative homodimer interface [polypeptide binding]; other site 550538008586 HMMPfam hit to PF04794, YdjC-like protein, score 6.7e-107 550538008587 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 550538008588 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 550538008589 NAD binding site [chemical binding]; other site 550538008590 sugar binding site [chemical binding]; other site 550538008591 divalent metal binding site [ion binding]; other site 550538008592 tetramer (dimer of dimers) interface [polypeptide binding]; other site 550538008593 dimer interface [polypeptide binding]; other site 550538008594 HMMPfam hit to PF02056, Glycoside hydrolase, family 4, score 2.2e-223 550538008595 PS01324 Glycosyl hydrolases family 4 signature. 550538008596 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 550538008597 Cupin domain; Region: Cupin_2; pfam07883 550538008598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538008599 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.1e-13 550538008600 PS00041 Bacterial regulatory proteins, araC family signature. 550538008601 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 0.00018 550538008602 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 550538008603 methionine cluster; other site 550538008604 active site 550538008605 phosphorylation site [posttranslational modification] 550538008606 metal binding site [ion binding]; metal-binding site 550538008607 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 2e-49 550538008608 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 550538008609 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 550538008610 10 probable transmembrane helices predicted for SG1803 by TMHMM2.0 at aa 31-53, 85-107, 114-133, 143-165, 186-208, 232-254, 302-321, 341-363, 370-392 and 407-429 550538008611 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.2e-61 550538008612 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008613 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 550538008614 active site 550538008615 P-loop; other site 550538008616 phosphorylation site [posttranslational modification] 550538008617 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 4.2e-25 550538008618 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 550538008619 HMMPfam hit to PF04355, SmpA/OmlA, score 2.6e-22 550538008620 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008621 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 550538008622 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 550538008623 homodimer interface [polypeptide binding]; other site 550538008624 NAD binding pocket [chemical binding]; other site 550538008625 ATP binding pocket [chemical binding]; other site 550538008626 Mg binding site [ion binding]; other site 550538008627 active-site loop [active] 550538008628 HMMPfam hit to PF02540, NAD+ synthase, score 7.2e-127 550538008629 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 550538008630 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 550538008631 GIY-YIG motif/motif A; other site 550538008632 active site 550538008633 catalytic site [active] 550538008634 putative DNA binding site [nucleotide binding]; other site 550538008635 metal binding site [ion binding]; metal-binding site 550538008636 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 1.2e-13 550538008637 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 550538008638 dimer interface [polypeptide binding]; other site 550538008639 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.0033 550538008640 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 1.3e-05 550538008641 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 550538008642 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 550538008643 putative active site [active] 550538008644 Zn binding site [ion binding]; other site 550538008645 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 1.1e-99 550538008646 succinylarginine dihydrolase; Provisional; Region: PRK13281 550538008647 HMMPfam hit to PF04996, Succinylarginine dihydrolase, score 0 550538008648 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 550538008649 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 550538008650 NAD(P) binding site [chemical binding]; other site 550538008651 catalytic residues [active] 550538008652 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 3.4e-119 550538008653 PS00070 Aldehyde dehydrogenases cysteine active site. 550538008654 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538008656 HMMPfam hit to PF04958, Arginine N-succinyltransferase beta subunit, score 5.5e-76 550538008657 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 550538008658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 550538008659 inhibitor-cofactor binding pocket; inhibition site 550538008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538008661 catalytic residue [active] 550538008662 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.7e-155 550538008663 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 550538008664 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 550538008665 putative catalytic site [active] 550538008666 putative phosphate binding site [ion binding]; other site 550538008667 active site 550538008668 metal binding site A [ion binding]; metal-binding site 550538008669 DNA binding site [nucleotide binding] 550538008670 putative AP binding site [nucleotide binding]; other site 550538008671 putative metal binding site B [ion binding]; other site 550538008672 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 9.5e-52 550538008673 PS00726 AP endonucleases family 1 signature 1. 550538008674 PS00728 AP endonucleases family 1 signature 3. 550538008675 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 550538008676 active site 550538008677 8-oxo-dGMP binding site [chemical binding]; other site 550538008678 nudix motif; other site 550538008679 metal binding site [ion binding]; metal-binding site 550538008680 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 8.2e-34 550538008681 PS00893 mutT domain signature. 550538008682 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 550538008683 HMMPfam hit to PF07383, Protein of unknown function DUF1496, score 1.1e-64 550538008685 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 4.7e-84 550538008686 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C-terminal, score 3.3e-140 550538008687 DNA topoisomerase III; Provisional; Region: PRK07726 550538008688 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 550538008689 active site 550538008690 putative interdomain interaction site [polypeptide binding]; other site 550538008691 putative metal-binding site [ion binding]; other site 550538008692 putative nucleotide binding site [chemical binding]; other site 550538008693 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 550538008694 domain I; other site 550538008695 DNA binding groove [nucleotide binding] 550538008696 phosphate binding site [ion binding]; other site 550538008697 domain II; other site 550538008698 domain III; other site 550538008699 nucleotide binding site [chemical binding]; other site 550538008700 catalytic site [active] 550538008701 domain IV; other site 550538008702 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 5.5e-190 550538008703 PS00396 Prokaryotic DNA topoisomerase I active site. 550538008704 HMMPfam hit to PF01751, TOPRIM, score 6.8e-36 550538008705 selenophosphate synthetase; Provisional; Region: PRK00943 550538008706 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 550538008707 dimerization interface [polypeptide binding]; other site 550538008708 putative ATP binding site [chemical binding]; other site 550538008709 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 6e-21 550538008710 HMMPfam hit to PF00586, AIR synthase related protein, score 3.8e-10 550538008711 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008712 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 550538008713 putative FMN binding site [chemical binding]; other site 550538008714 HMMPfam hit to PF00881, Nitroreductase, score 5.8e-40 550538008715 protease 4; Provisional; Region: PRK10949 550538008716 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 550538008717 tandem repeat interface [polypeptide binding]; other site 550538008718 oligomer interface [polypeptide binding]; other site 550538008719 active site residues [active] 550538008720 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 550538008721 tandem repeat interface [polypeptide binding]; other site 550538008722 oligomer interface [polypeptide binding]; other site 550538008723 active site residues [active] 550538008724 1 probable transmembrane helix predicted for SG1821 by TMHMM2.0 at aa 21-43 550538008725 HMMPfam hit to PF01343, Peptidase S49, score 8.5e-55 550538008726 HMMPfam hit to PF01343, Peptidase S49, score 1.7e-73 550538008727 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 550538008728 active site 550538008729 homodimer interface [polypeptide binding]; other site 550538008730 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 3.3e-140 550538008731 PS00144 Asparaginase / glutaminase active site signature 1. 550538008732 PS00917 Asparaginase / glutaminase active site signature 2. 550538008733 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 550538008734 Isochorismatase family; Region: Isochorismatase; pfam00857 550538008735 catalytic triad [active] 550538008736 metal binding site [ion binding]; metal-binding site 550538008737 conserved cis-peptide bond; other site 550538008738 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 9e-79 550538008740 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.5e-31 550538008741 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538008742 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538008743 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538008744 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 7.7e-44 550538008745 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.3e-19 550538008746 PS00894 Bacterial regulatory proteins, deoR family signature. 550538008747 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538008748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538008749 active site 550538008750 catalytic tetrad [active] 550538008751 HMMPfam hit to PF00248, Aldo/keto reductase, score 1.2e-41 550538008752 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 550538008753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538008754 substrate binding site [chemical binding]; other site 550538008755 ATP binding site [chemical binding]; other site 550538008756 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.8e-79 550538008757 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008758 PS00584 pfkB family of carbohydrate kinases signature 2. 550538008759 PS00583 pfkB family of carbohydrate kinases signature 1. 550538008760 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 550538008761 intersubunit interface [polypeptide binding]; other site 550538008762 active site 550538008763 zinc binding site [ion binding]; other site 550538008764 Na+ binding site [ion binding]; other site 550538008765 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 1.3e-67 550538008766 the sequence has been checked and is believed to be correct 550538008767 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 7.6e-39 550538008768 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 2.1e-41 550538008769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538008770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538008771 12 probable transmembrane helices predicted for SG1831 by TMHMM2.0 at aa 25-47, 60-82, 89-108, 112-134, 154-176, 180-202, 266-288, 301-323, 330-352, 356-378, 391-413 and 418-440 550538008772 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.6e-26 550538008773 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 550538008774 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 550538008775 putative NAD(P) binding site [chemical binding]; other site 550538008776 catalytic Zn binding site [ion binding]; other site 550538008777 structural Zn binding site [ion binding]; other site 550538008778 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.2e-40 550538008779 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.8e-33 550538008780 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538008781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 550538008782 HMMPfam hit to PF07023, Protein of unknown function DUF1315, score 4.6e-59 550538008783 methionine sulfoxide reductase B; Provisional; Region: PRK00222 550538008784 SelR domain; Region: SelR; pfam01641 550538008785 HMMPfam hit to PF01641, Methionine sulphoxide reductase B, score 2.9e-87 550538008786 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 550538008787 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 550538008788 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 550538008789 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 1.2e-98 550538008790 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 550538008791 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 1.7e-117 550538008792 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 550538008793 active site 550538008794 phosphate binding residues; other site 550538008795 catalytic residues [active] 550538008796 HMMPfam hit to PF01263, Aldose 1-epimerase, score 3.8e-44 550538008797 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538008799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538008800 active site 550538008801 catalytic tetrad [active] 550538008802 HMMPfam hit to PF00248, Aldo/keto reductase, score 3.5e-63 550538008804 HMMPfam hit to PF04055, Radical SAM, score 2.1e-09 550538008806 HMMPfam hit to PF00990, GGDEF, score 1e-11 550538008807 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 550538008808 putative deacylase active site [active] 550538008809 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 4.2e-47 550538008810 Predicted membrane protein [Function unknown]; Region: COG2707 550538008811 HMMPfam hit to PF04284, Protein of unknown function DUF441, transmembrame, score 1.5e-88 550538008812 4 probable transmembrane helices predicted for SG1843 by TMHMM2.0 at aa 12-34, 49-71, 76-98 and 124-146 550538008813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 550538008814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538008815 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.6e-06 550538008816 PS00041 Bacterial regulatory proteins, araC family signature. 550538008817 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 550538008818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538008819 12 probable transmembrane helices predicted for SG1845 by TMHMM2.0 at aa 12-31, 46-68, 81-98, 103-125, 137-159, 163-185, 217-239, 249-271, 278-297, 302-324, 333-355 and 365-387 550538008820 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3e-28 550538008821 Uncharacterized conserved protein [Function unknown]; Region: COG3189 550538008822 HMMPfam hit to PF04343, Protein of unknown function DUF488, score 1.1e-39 550538008823 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008824 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 550538008825 murein hydrolase B; Provisional; Region: PRK10760; cl17906 550538008826 Domain of unknown function (DUF333); Region: DUF333; pfam03891 550538008827 HMMPfam hit to PF03891, Protein of unknown function DUF333, score 6.1e-24 550538008828 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008829 hypothetical protein; Provisional; Region: PRK10457 550538008830 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 2.9e-19 550538008831 3 probable transmembrane helices predicted for SG1849 by TMHMM2.0 at aa 4-21, 28-50 and 60-77 550538008832 4 probable transmembrane helices predicted for SG1851 by TMHMM2.0 at aa 7-25, 40-59, 71-90 and 100-122 550538008833 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 550538008834 HMMPfam hit to PF08956, Protein of unknown function DUF1869, score 3.5e-49 550538008835 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 550538008836 HMMPfam hit to PF09313, Protein of unknown function DUF1971, score 4.4e-37 550538008837 leucine export protein LeuE; Provisional; Region: PRK10958 550538008838 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 4.7e-61 550538008839 6 probable transmembrane helices predicted for SG1854 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 157-179 and 191-210 550538008840 chorismate mutase; Provisional; Region: PRK08055 550538008841 HMMPfam hit to PF01817, Chorismate mutase, score 5.1e-13 550538008842 Pleckstrin homology-like domain; Region: PH-like; cl17171 550538008843 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 550538008844 transcriptional regulator MirA; Provisional; Region: PRK15043 550538008845 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 550538008846 DNA binding residues [nucleotide binding] 550538008847 dimer interface [polypeptide binding]; other site 550538008848 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 4.3e-10 550538008849 PS00552 Bacterial regulatory proteins, merR family signature. 550538008850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538008851 DNA binding residues [nucleotide binding] 550538008852 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.3e-07 550538008853 aminoglycoside resistance protein; Provisional; Region: PRK13746 550538008854 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 550538008855 active site 550538008856 NTP binding site [chemical binding]; other site 550538008857 metal binding triad [ion binding]; metal-binding site 550538008858 antibiotic binding site [chemical binding]; other site 550538008859 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 550538008860 HMMPfam hit to PF01909, DNA polymerase, beta-like region, score 1.5e-12 550538008861 zinc/cadmium-binding protein; Provisional; Region: PRK10306 550538008862 HMMPfam hit to PF09223, YodA, score 5.9e-126 550538008863 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 550538008864 dimerization interface [polypeptide binding]; other site 550538008865 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.06 550538008866 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.0016 550538008867 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.025 550538008868 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 2.1 550538008870 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 3.2e-75 550538008871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538008872 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 550538008873 Walker A/P-loop; other site 550538008874 ATP binding site [chemical binding]; other site 550538008875 Q-loop/lid; other site 550538008876 ABC transporter signature motif; other site 550538008877 Walker B; other site 550538008878 D-loop; other site 550538008879 H-loop/switch region; other site 550538008880 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-26 550538008881 PS00211 ABC transporters family signature. 550538008882 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538008884 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 550538008885 Walker A/P-loop; other site 550538008886 ATP binding site [chemical binding]; other site 550538008887 Q-loop/lid; other site 550538008888 ABC transporter signature motif; other site 550538008889 Walker B; other site 550538008890 D-loop; other site 550538008891 H-loop/switch region; other site 550538008892 HMMPfam hit to PF00005, ABC transporter related, score 2.7e-34 550538008893 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 550538008895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538008896 dimer interface [polypeptide binding]; other site 550538008897 conserved gate region; other site 550538008898 putative PBP binding loops; other site 550538008899 ABC-ATPase subunit interface; other site 550538008900 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.6e-21 550538008901 4 probable transmembrane helices predicted for SG1867 by TMHMM2.0 at aa 7-29, 74-96, 117-139 and 236-253 550538008902 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 550538008903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538008904 dimer interface [polypeptide binding]; other site 550538008905 conserved gate region; other site 550538008906 ABC-ATPase subunit interface; other site 550538008907 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3e-53 550538008908 4 probable transmembrane helices predicted for SG1868 by TMHMM2.0 at aa 7-29, 104-126, 139-161 and 291-313 550538008909 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 550538008910 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 550538008911 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 2.8e-82 550538008912 1 probable transmembrane helix predicted for SG1869 by TMHMM2.0 at aa 21-40 550538008913 TRL-like protein family; Region: TRL; pfam13146 550538008914 1 probable transmembrane helix predicted for SG1870 by TMHMM2.0 at aa 7-29 550538008915 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008916 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 550538008917 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 2.1e-59 550538008918 4 probable transmembrane helices predicted for SG1871 by TMHMM2.0 at aa 9-31, 46-63, 88-110 and 140-162 550538008919 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 550538008920 BNR repeat-like domain; Region: BNR_2; pfam13088 550538008921 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 13 550538008922 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 33 550538008923 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 32 550538008924 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 13 550538008925 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 550538008926 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 550538008927 putative dimer interface [polypeptide binding]; other site 550538008928 HMMPfam hit to PF00011, Heat shock protein Hsp20, score 1.2e-12 550538008929 lysozyme inhibitor; Provisional; Region: PRK13791 550538008930 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 550538008931 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 7e-21 550538008932 PS00695 Enterobacterial virulence outer membrane protein signature 2. 550538008933 PS00694 Enterobacterial virulence outer membrane protein signature 1. 550538008934 the sequence has been checked and is believed to be correct 550538008935 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 4.8e-17 550538008936 Ricin-type beta-trefoil; Region: RICIN; smart00458 550538008937 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 550538008938 putative sugar binding sites [chemical binding]; other site 550538008939 Q-X-W motif; other site 550538008940 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538008941 HMMPfam hit to PF00652, Ricin B lectin, score 4.6e-28 550538008942 DinI-like family; Region: DinI; pfam06183 550538008943 HMMPfam hit to PF06183, DinI-like, score 2.2e-31 550538008944 the sequence has been checked and is believed to be correct 550538008945 CDS has suffered many deletion events 550538008946 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 8.3e-08 550538008947 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 550538008948 PS00017 ATP/GTP-binding site motif A (P-loop). 550538008949 isocitrate dehydrogenase; Validated; Region: PRK07362 550538008950 isocitrate dehydrogenase; Reviewed; Region: PRK07006 550538008951 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 3.4e-164 550538008952 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 550538008953 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 550538008954 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 550538008955 probable active site [active] 550538008956 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.2e-21 550538008957 PS01149 Rsu family of pseudouridine synthase signature. 550538008958 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 550538008959 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 550538008960 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 550538008961 nudix motif; other site 550538008962 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 3.9e-28 550538008963 PS00893 mutT domain signature. 550538008964 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 550538008965 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 550538008966 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 4.9e-235 550538008967 PS00070 Aldehyde dehydrogenases cysteine active site. 550538008968 putative lysogenization regulator; Reviewed; Region: PRK00218 550538008969 HMMPfam hit to PF04356, Protein of unknown function DUF489, score 4e-140 550538008970 adenylosuccinate lyase; Provisional; Region: PRK09285 550538008971 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 550538008972 tetramer interface [polypeptide binding]; other site 550538008973 active site 550538008974 HMMPfam hit to PF00206, Fumarate lyase, score 6.3e-111 550538008975 PS00163 Fumarate lyases signature. 550538008976 HMMPfam hit to PF08328, Adenylosuccinate lyase C-terminal, score 1.8e-89 550538008977 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 550538008978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538008979 active site 550538008980 phosphorylation site [posttranslational modification] 550538008981 intermolecular recognition site; other site 550538008982 dimerization interface [polypeptide binding]; other site 550538008983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538008984 DNA binding site [nucleotide binding] 550538008985 HMMPfam hit to PF00072, Response regulator receiver, score 3.5e-31 550538008986 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.3e-17 550538008987 sensor protein PhoQ; Provisional; Region: PRK10815 550538008988 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 550538008989 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 550538008990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538008991 ATP binding site [chemical binding]; other site 550538008992 Mg2+ binding site [ion binding]; other site 550538008993 G-X-G motif; other site 550538008994 HMMPfam hit to PF08918, PhoQ Sensor, score 1.4e-126 550538008995 2 probable transmembrane helices predicted for SG1891 by TMHMM2.0 at aa 20-42 and 194-216 550538008996 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 7.7e-09 550538008997 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.00076 550538008998 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.4e-28 550538008999 Uncharacterized conserved protein [Function unknown]; Region: COG2850 550538009000 Cupin domain; Region: Cupin_2; cl17218 550538009001 HMMPfam hit to PF08007, Cupin 4, score 5.7e-152 550538009002 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 550538009003 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 550538009004 metal binding site [ion binding]; metal-binding site 550538009005 dimer interface [polypeptide binding]; other site 550538009006 HMMPfam hit to PF01546, Peptidase M20, score 1.3e-17 550538009007 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 9.3e-28 550538009008 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 550538009009 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 550538009010 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 550538009011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538009012 Walker A/P-loop; other site 550538009013 ATP binding site [chemical binding]; other site 550538009014 Q-loop/lid; other site 550538009015 ABC transporter signature motif; other site 550538009016 Walker B; other site 550538009017 D-loop; other site 550538009018 H-loop/switch region; other site 550538009019 TOBE domain; Region: TOBE_2; pfam08402 550538009020 HMMPfam hit to PF00005, ABC transporter related, score 8.2e-66 550538009021 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009022 PS00211 ABC transporters family signature. 550538009023 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 1.2e-07 550538009024 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 550538009025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538009026 dimer interface [polypeptide binding]; other site 550538009027 conserved gate region; other site 550538009028 putative PBP binding loops; other site 550538009029 ABC-ATPase subunit interface; other site 550538009030 6 probable transmembrane helices predicted for SG1896 by TMHMM2.0 at aa 9-31, 69-91, 98-120, 151-173, 194-216 and 250-272 550538009031 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.9e-14 550538009032 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538009033 Sif protein; Region: Sif; pfam06767 550538009034 HMMPfam hit to PF06767, Sif, score 1.1e-242 550538009035 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 550538009036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538009037 dimer interface [polypeptide binding]; other site 550538009038 conserved gate region; other site 550538009039 putative PBP binding loops; other site 550538009040 ABC-ATPase subunit interface; other site 550538009041 6 probable transmembrane helices predicted for SG1898 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 176-195 and 230-252 550538009042 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.3e-12 550538009043 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538009044 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 550538009045 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 550538009046 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 6.3e-12 550538009047 NAD-dependent deacetylase; Provisional; Region: PRK00481 550538009048 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 550538009049 NAD+ binding site [chemical binding]; other site 550538009050 substrate binding site [chemical binding]; other site 550538009051 Zn binding site [ion binding]; other site 550538009052 HMMPfam hit to PF02146, Silent information regulator protein Sir2, score 2.6e-86 550538009053 fructokinase; Reviewed; Region: PRK09557 550538009054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538009055 nucleotide binding site [chemical binding]; other site 550538009056 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538009057 HMMPfam hit to PF00480, ROK, score 1.8e-55 550538009058 PS01125 ROK family signature. 550538009059 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 550538009060 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 550538009061 FtsX-like permease family; Region: FtsX; pfam02687 550538009062 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 3.3e-50 550538009063 PS00027 'Homeobox' domain signature. 550538009064 4 probable transmembrane helices predicted for SG1902 by TMHMM2.0 at aa 21-43, 270-292, 318-340 and 375-397 550538009065 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 550538009066 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 550538009067 Walker A/P-loop; other site 550538009068 ATP binding site [chemical binding]; other site 550538009069 Q-loop/lid; other site 550538009070 ABC transporter signature motif; other site 550538009071 Walker B; other site 550538009072 D-loop; other site 550538009073 H-loop/switch region; other site 550538009074 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-65 550538009075 PS00211 ABC transporters family signature. 550538009076 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009077 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 550538009078 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 550538009079 FtsX-like permease family; Region: FtsX; pfam02687 550538009080 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 3e-48 550538009081 4 probable transmembrane helices predicted for SG1904 by TMHMM2.0 at aa 25-47, 266-288, 318-340 and 360-382 550538009082 transcription-repair coupling factor; Provisional; Region: PRK10689 550538009083 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 550538009084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538009085 ATP binding site [chemical binding]; other site 550538009086 putative Mg++ binding site [ion binding]; other site 550538009087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538009088 nucleotide binding region [chemical binding]; other site 550538009089 ATP-binding site [chemical binding]; other site 550538009090 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 550538009091 HMMPfam hit to PF02559, Transcription factor CarD, score 2.6e-49 550538009092 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 4.2e-43 550538009093 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009094 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.6e-21 550538009095 HMMPfam hit to PF03461, TRCF, score 5.1e-56 550538009096 L,D-transpeptidase; Provisional; Region: PRK10190 550538009097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538009098 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 550538009099 1 probable transmembrane helix predicted for SG1906 by TMHMM2.0 at aa 7-29 550538009100 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 4e-08 550538009101 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 1.3e-66 550538009102 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538009103 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 4.5e-23 550538009104 1 probable transmembrane helix predicted for SG1907 by TMHMM2.0 at aa 7-29 550538009105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 550538009106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538009107 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 1e-15 550538009109 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 1.8e-06 550538009110 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 550538009111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538009112 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.3e-33 550538009113 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.9e-23 550538009114 hypothetical protein; Provisional; Region: PRK04940 550538009115 HMMPfam hit to PF05728, Protein of unknown function UPF0227, score 1.1e-106 550538009116 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 550538009117 beta-hexosaminidase; Provisional; Region: PRK05337 550538009118 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 1.5e-83 550538009119 PS00775 Glycosyl hydrolases family 3 active site. 550538009120 thiamine kinase; Region: ycfN_thiK; TIGR02721 550538009121 thiamine kinase; Provisional; Region: thiK; PRK10271 550538009122 substrate binding site [chemical binding]; other site 550538009123 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 1.5e-26 550538009124 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 550538009125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009126 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 550538009127 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 550538009128 putative dimer interface [polypeptide binding]; other site 550538009129 HMMPfam hit to PF07233, Protein of unknown function DUF1425, score 1.6e-58 550538009130 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009131 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 550538009132 nucleotide binding site/active site [active] 550538009133 HIT family signature motif; other site 550538009134 catalytic residue [active] 550538009135 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 1e-47 550538009136 PS00892 HIT family signature. 550538009137 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 550538009138 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 550538009139 N-terminal plug; other site 550538009140 ligand-binding site [chemical binding]; other site 550538009141 PS00430 TonB-dependent receptor proteins signature 1. 550538009142 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 4.9e-19 550538009143 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 4.6e-27 550538009144 PS01156 TonB-dependent receptor proteins signature 2. 550538009145 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 550538009146 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 550538009147 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 550538009148 active site turn [active] 550538009149 phosphorylation site [posttranslational modification] 550538009150 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 2.7e-18 550538009151 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 550538009152 10 probable transmembrane helices predicted for SG1919 by TMHMM2.0 at aa 12-34, 49-71, 76-98, 113-135, 155-177, 192-214, 248-270, 280-302, 309-331 and 354-376 550538009153 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.8e-107 550538009154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 550538009155 active site 550538009156 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 1.5e-118 550538009157 PS01091 Uncharacterized protein family UPF0006 signature 3. 550538009158 PS01137 Uncharacterized protein family UPF0006 signature 1. 550538009159 DNA polymerase III subunit delta'; Validated; Region: PRK07993 550538009160 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 550538009161 HMMPfam hit to PF09115, DNA polymerase III, delta subunit, C-terminal, score 8.2e-51 550538009162 thymidylate kinase; Validated; Region: tmk; PRK00698 550538009163 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 550538009164 TMP-binding site; other site 550538009165 ATP-binding site [chemical binding]; other site 550538009166 HMMPfam hit to PF02223, Thymidylate kinase, score 4.6e-85 550538009167 PS01331 Thymidylate kinase signature. 550538009168 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009169 conserved hypothetical protein, YceG family; Region: TIGR00247 550538009170 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 550538009171 dimerization interface [polypeptide binding]; other site 550538009172 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 9.5e-153 550538009173 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 550538009174 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 550538009175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538009176 catalytic residue [active] 550538009177 HMMPfam hit to PF01063, Aminotransferase, class IV, score 6.8e-44 550538009178 PS00770 Aminotransferases class-IV signature. 550538009179 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 550538009180 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 550538009181 dimer interface [polypeptide binding]; other site 550538009182 active site 550538009183 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal, score 9.5e-59 550538009184 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal, score 2.3e-75 550538009185 PS00606 Beta-ketoacyl synthases active site. 550538009186 acyl carrier protein; Provisional; Region: acpP; PRK00982 550538009187 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538009188 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 4.3e-24 550538009189 PS00012 Phosphopantetheine attachment site. 550538009190 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 550538009191 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 550538009192 NAD(P) binding site [chemical binding]; other site 550538009193 homotetramer interface [polypeptide binding]; other site 550538009194 homodimer interface [polypeptide binding]; other site 550538009195 active site 550538009196 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.4e-41 550538009197 PS00061 Short-chain dehydrogenases/reductases family signature. 550538009198 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 550538009199 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 550538009200 HMMPfam hit to PF00698, Acyl transferase, score 1.8e-20 550538009201 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 550538009202 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 550538009203 dimer interface [polypeptide binding]; other site 550538009204 active site 550538009205 CoA binding pocket [chemical binding]; other site 550538009206 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal, score 1.1e-52 550538009207 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, score 1.3e-43 550538009208 putative phosphate acyltransferase; Provisional; Region: PRK05331 550538009209 HMMPfam hit to PF02504, Fatty acid synthesis plsX protein, score 6.1e-178 550538009210 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 550538009211 HMMPfam hit to PF01783, Ribosomal protein L32p, score 2.3e-20 550538009212 hypothetical protein; Provisional; Region: PRK11193 550538009213 HMMPfam hit to PF02620, Protein of unknown function DUF177, score 6.8e-57 550538009214 Maf-like protein; Region: Maf; pfam02545 550538009215 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 550538009216 active site 550538009217 dimer interface [polypeptide binding]; other site 550538009218 HMMPfam hit to PF02545, Maf-like protein, score 1.4e-88 550538009219 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 550538009220 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009221 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 550538009222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538009223 RNA binding surface [nucleotide binding]; other site 550538009224 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 550538009225 active site 550538009226 HMMPfam hit to PF00849, Pseudouridine synthase, score 5.2e-61 550538009227 PS01129 Rlu family of pseudouridine synthase signature. 550538009228 HMMPfam hit to PF01479, RNA-binding S4, score 3.9e-11 550538009229 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 550538009230 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 550538009231 homodimer interface [polypeptide binding]; other site 550538009232 oligonucleotide binding site [chemical binding]; other site 550538009233 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 550538009234 HMMPfam hit to PF00575, S1, RNA binding, score 6.1e-19 550538009235 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 550538009236 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 550538009237 HMMPfam hit to PF00669, Flagellin, N-terminal, score 8e-40 550538009238 the sequence has been checked and is believed to be correct 550538009239 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 5.1e-16 550538009240 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 1.1e-10 550538009241 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 550538009242 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 550538009243 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 550538009244 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 2.3e-69 550538009245 the sequence has been checked and is believed to be correct 550538009246 HMMPfam hit to PF02119, Flagellar P-ring protein, score 1.2e-239 550538009247 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 550538009248 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 550538009249 HMMPfam hit to PF02107, Flagellar L-ring protein, score 1.1e-117 550538009250 1 probable transmembrane helix predicted for SG1942 by TMHMM2.0 at aa 5-27 550538009251 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009252 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 550538009253 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 550538009254 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 550538009255 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 1.3e-18 550538009256 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 5.4e-15 550538009257 PS00588 Flagella basal body rod proteins signature. 550538009258 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 550538009259 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 550538009260 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 550538009261 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 0.002 550538009262 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 3.7e-11 550538009263 PS00588 Flagella basal body rod proteins signature. 550538009264 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 550538009265 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 550538009266 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 550538009267 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 550538009268 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 6.8e-20 550538009269 HMMPfam hit to PF07559, Flagellar basal body FlaE, score 1.9e-26 550538009270 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 8.7e-13 550538009271 PS00588 Flagella basal body rod proteins signature. 550538009272 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 550538009273 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 550538009274 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 550538009275 HMMPfam hit to PF03963, Flagellar hook capping protein, score 1.8e-51 550538009276 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 550538009277 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 550538009278 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 550538009279 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 1.9e-06 550538009280 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 1.8e-11 550538009281 PS00588 Flagella basal body rod proteins signature. 550538009282 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 550538009283 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 550538009284 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 2.2e-12 550538009285 PS00588 Flagella basal body rod proteins signature. 550538009286 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 550538009287 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 550538009288 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 550538009289 HMMPfam hit to PF08666, SAF domain, score 4.7e-11 550538009290 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 550538009291 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 1e-27 550538009292 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 550538009293 HMMPfam hit to PF05130, FlgN, score 5.5e-59 550538009294 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 550538009295 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 550538009296 13 probable transmembrane helices predicted for SG1952 by TMHMM2.0 at aa 39-58, 95-117, 143-165, 172-194, 199-221, 250-272, 287-309, 322-341, 361-383, 396-418, 423-440, 457-479 and 494-516 550538009297 HMMPfam hit to PF03023, Virulence factor MVIN-like, score 2e-216 550538009298 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 550538009299 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 550538009300 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 550538009301 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 3e-07 550538009302 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538009303 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 6.7e-39 550538009304 the sequence has been checked and is believed to be correct 550538009305 HMMPfam hit to PF04337, Protein of unknown function DUF480, score 1.6e-128 550538009306 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 550538009307 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 550538009308 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.9e-13 550538009309 multidrug resistance protein MdtH; Provisional; Region: PRK11646 550538009310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538009311 putative substrate translocation pore; other site 550538009312 10 probable transmembrane helices predicted for SG1956 by TMHMM2.0 at aa 13-35, 99-116, 136-158, 163-185, 210-232, 247-266, 273-295, 300-322, 335-357 and 367-389 550538009313 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 7.6e-45 550538009314 glutaredoxin 2; Provisional; Region: PRK10387 550538009315 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 550538009316 C-terminal domain interface [polypeptide binding]; other site 550538009317 GSH binding site (G-site) [chemical binding]; other site 550538009318 catalytic residues [active] 550538009319 putative dimer interface [polypeptide binding]; other site 550538009320 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 550538009321 N-terminal domain interface [polypeptide binding]; other site 550538009322 HMMPfam hit to PF00462, Glutaredoxin, score 1.2e-05 550538009323 PS00195 Glutaredoxin active site. 550538009324 HMMPfam hit to PF04399, Glutaredoxin 2, C-terminal, score 1.5e-75 550538009325 lipoprotein; Provisional; Region: PRK10598 550538009326 HMMPfam hit to PF07273, Protein of unknown function DUF1439, score 1.6e-109 550538009327 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 550538009328 active site 550538009329 substrate binding pocket [chemical binding]; other site 550538009330 dimer interface [polypeptide binding]; other site 550538009331 HMMPfam hit to PF01979, Amidohydrolase 1, score 7.8e-33 550538009332 PS00482 Dihydroorotase signature 1. 550538009333 PS00483 Dihydroorotase signature 2. 550538009334 DNA damage-inducible protein I; Provisional; Region: PRK10597 550538009335 HMMPfam hit to PF06183, DinI-like, score 1.7e-35 550538009336 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 550538009337 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 550538009338 hydroxyglutarate oxidase; Provisional; Region: PRK11728 550538009339 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 7.3e-61 550538009340 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009341 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 550538009342 1 probable transmembrane helix predicted for SG1963 by TMHMM2.0 at aa 15-36 550538009343 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 550538009344 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 1.6e-65 550538009345 4 probable transmembrane helices predicted for SG1964 by TMHMM2.0 at aa 13-35, 55-72, 92-114 and 147-169 550538009346 hypothetical protein; Provisional; Region: PRK03757 550538009347 HMMPfam hit to PF04264, Lipid/polyisoprenoid-binding, YceI-like, score 6e-84 550538009348 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 550538009349 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 550538009350 active site residue [active] 550538009351 HMMPfam hit to PF00581, Rhodanese-like, score 1.7e-28 550538009352 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009353 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 550538009354 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 550538009355 putative acyl-acceptor binding pocket; other site 550538009356 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltransferase, score 3.5e-155 550538009357 2 probable transmembrane helices predicted for SG1967 by TMHMM2.0 at aa 20-42 and 123-145 550538009358 drug efflux system protein MdtG; Provisional; Region: PRK09874 550538009359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538009360 putative substrate translocation pore; other site 550538009361 10 probable transmembrane helices predicted for SG1968 by TMHMM2.0 at aa 13-35, 50-72, 84-103, 108-130, 142-164, 174-196, 217-239, 254-276, 288-310 and 371-393 550538009362 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.6e-49 550538009363 secY/secA suppressor protein; Provisional; Region: PRK11467 550538009364 lipoprotein; Provisional; Region: PRK10175 550538009365 HMMPfam hit to PF07119, Protein of unknown function DUF1375, score 4.4e-36 550538009366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009367 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 550538009368 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 550538009369 Ligand binding site; other site 550538009370 DXD motif; other site 550538009371 6 probable transmembrane helices predicted for SG1971 by TMHMM2.0 at aa 139-156, 194-216, 512-534, 568-590, 603-625 and 680-702 550538009372 PS00213 Lipocalin signature. 550538009373 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.4e-13 550538009374 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 550538009375 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 550538009376 HMMPfam hit to PF04349, Glucan biosynthesis, periplasmic, MdoG C-terminal, score 0 550538009377 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 550538009378 Acyltransferase family; Region: Acyl_transf_3; pfam01757 550538009379 HMMPfam hit to PF01757, Acyltransferase 3, score 6.7e-50 550538009380 10 probable transmembrane helices predicted for SG1973 by TMHMM2.0 at aa 17-39, 54-76, 88-110, 139-161, 174-193, 213-232, 245-262, 277-299, 306-328 and 338-360 550538009381 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 550538009382 PLD-like domain; Region: PLDc_2; pfam13091 550538009383 putative active site [active] 550538009384 catalytic site [active] 550538009385 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 550538009386 PLD-like domain; Region: PLDc_2; pfam13091 550538009387 putative active site [active] 550538009388 catalytic site [active] 550538009389 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.0051 550538009390 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.36 550538009391 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 550538009392 putative ADP-ribose binding site [chemical binding]; other site 550538009393 putative active site [active] 550538009394 HMMPfam hit to PF01661, Appr-1-p processing, score 7.2e-69 550538009395 Fimbrial protein; Region: Fimbrial; cl01416 550538009396 fimbrial operon csg 550538009397 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 550538009398 major curlin subunit; Provisional; Region: csgA; PRK10051 550538009399 Curlin associated repeat; Region: Curlin_rpt; pfam07012 550538009400 HMMPfam hit to PF07012, Curlin associated, score 0.0013 550538009401 HMMPfam hit to PF07012, Curlin associated, score 1e-11 550538009402 HMMPfam hit to PF07012, Curlin associated, score 1.9e-11 550538009403 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 550538009404 Curlin associated repeat; Region: Curlin_rpt; pfam07012 550538009405 Curlin associated repeat; Region: Curlin_rpt; pfam07012 550538009406 HMMPfam hit to PF07012, Curlin associated, score 1.2e-09 550538009407 HMMPfam hit to PF07012, Curlin associated, score 2.4e-12 550538009408 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 550538009409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538009410 DNA binding residues [nucleotide binding] 550538009411 dimerization interface [polypeptide binding]; other site 550538009412 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2.1e-21 550538009413 PS00622 Bacterial regulatory proteins, luxR family signature. 550538009414 curli assembly protein CsgE; Provisional; Region: PRK10386 550538009415 curli assembly protein CsgF; Provisional; Region: PRK10050 550538009416 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 550538009417 HMMPfam hit to PF03783, Curli production assembly/transport component CsgG, score 5.1e-106 550538009418 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 550538009419 HMMPfam hit to PF06496, Protein of unknown function DUF1097, score 5e-101 550538009420 6 probable transmembrane helices predicted for SG1984 by TMHMM2.0 at aa 12-31, 36-58, 65-84, 88-110, 115-134 and 139-161 550538009422 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 2.4e-39 550538009424 HMMPfam hit to PF02811, PHP, C-terminal, score 3.9e-06 550538009425 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 550538009426 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 550538009427 putative ligand binding site [chemical binding]; other site 550538009428 NAD binding site [chemical binding]; other site 550538009429 dimerization interface [polypeptide binding]; other site 550538009430 catalytic site [active] 550538009431 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 4.1e-48 550538009432 the sequence has been checked and is believed to be correct 550538009434 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.1e-10 550538009435 Transposase; Region: DEDD_Tnp_IS110; pfam01548 550538009436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 550538009437 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 550538009438 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 4.6e-25 550538009439 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 5.2e-06 550538009440 1 probable transmembrane helix predicted for SG1991 by TMHMM2.0 at aa 218-240 550538009442 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 550538009443 HMMPfam hit to PF06167, Protein of unknown function DUF980, score 1.4e-143 550538009444 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538009445 the sequence has been checked and is believed to be correct 550538009446 ROD21, Genomic Island;bounded by 30bp repeats 550538009447 integrase; Provisional; Region: PRK09692 550538009448 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 550538009449 active site 550538009450 Int/Topo IB signature motif; other site 550538009451 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.2e-26 550538009453 1 probable transmembrane helix predicted for SG1999 by TMHMM2.0 at aa 65-84 550538009454 TIR domain; Region: TIR_2; pfam13676 550538009455 HMMPfam hit to PF01582, Toll-Interleukin receptor, score 3.2e-07 550538009457 HMMPfam hit to PF04917, Bacterial shufflon protein, N-terminal, score 2.4e-08 550538009458 HMMPfam hit to PF07484, Phage Tail Collar, score 1.5e-18 550538009459 PilS N terminal; Region: PilS; pfam08805 550538009460 HMMPfam hit to PF08805, PilS N terminal, score 4.7e-29 550538009461 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 0.0013 550538009462 1 probable transmembrane helix predicted for SG2004 by TMHMM2.0 at aa 13-35 550538009463 PS00409 Prokaryotic N-terminal methylation site. 550538009464 Conjugal transfer protein TraD; Region: TraD; pfam06412 550538009465 MobA/MobL family; Region: MobA_MobL; pfam03389 550538009466 HMMPfam hit to PF03389, MobA/MobL protein, score 8.6e-42 550538009468 2 probable transmembrane helices predicted for SG2008 by TMHMM2.0 at aa 29-51 and 66-88 550538009469 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009470 1 probable transmembrane helix predicted for SG2010 by TMHMM2.0 at aa 10-27 550538009471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538009472 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 550538009473 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 550538009474 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 550538009475 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 2.1e-46 550538009476 2 probable transmembrane helices predicted for SG2020 by TMHMM2.0 at aa 47-64 and 69-88 550538009477 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 550538009478 active site 550538009479 NTP binding site [chemical binding]; other site 550538009480 metal binding triad [ion binding]; metal-binding site 550538009481 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 550538009482 HMMPfam hit to PF05930, Prophage CP4-57 regulatory, score 4.9e-25 550538009483 putative protease; Region: PHA00666 550538009484 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 550538009485 Integrase; Region: Integrase_1; pfam12835 550538009486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 550538009487 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538009488 Sel1 repeat; Region: Sel1; pfam08238 550538009489 Sel1-like repeats; Region: SEL1; smart00671 550538009490 HMMPfam hit to PF07661, MORN variant, score 0.88 550538009491 HMMPfam hit to PF07661, MORN variant, score 3 550538009492 HMMPfam hit to PF07661, MORN variant, score 3.3 550538009493 HMMPfam hit to PF07661, MORN variant, score 1.4 550538009494 HMMPfam hit to PF07661, MORN variant, score 0.06 550538009495 HMMPfam hit to PF07661, MORN variant, score 1.8 550538009496 HMMPfam hit to PF07661, MORN variant, score 0.0023 550538009497 HMMPfam hit to PF07661, MORN variant, score 20 550538009498 HMMPfam hit to PF07661, MORN variant, score 0.36 550538009499 HMMPfam hit to PF07661, MORN variant, score 2.5 550538009500 HMMPfam hit to PF07661, MORN variant, score 0.18 550538009501 HMMPfam hit to PF07661, MORN variant, score 2.9 550538009502 HMMPfam hit to PF07661, MORN variant, score 3.1 550538009503 HMMPfam hit to PF07661, MORN variant, score 3.7 550538009504 HMMPfam hit to PF08238, Sel1-like, score 4.3e-05 550538009505 HMMPfam hit to PF08238, Sel1-like, score 6e-06 550538009506 HMMPfam hit to PF08238, Sel1-like, score 1.5e-08 550538009507 HMMPfam hit to PF08238, Sel1-like, score 3.4e-07 550538009509 HMMPfam hit to PF04461, Protein of unknown function DUF520, score 1.2e-20 550538009511 AMP nucleosidase; Provisional; Region: PRK08292 550538009512 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 550538009513 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 550538009514 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 7.1e-98 550538009515 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 550538009516 HMMPfam hit to PF07377, Protein of unknown function DUF1493, score 5.6e-77 550538009517 MATE family multidrug exporter; Provisional; Region: PRK10189 550538009518 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 550538009519 11 probable transmembrane helices predicted for SG2038 by TMHMM2.0 at aa 49-71, 86-108, 128-150, 160-182, 194-216, 231-253, 266-286, 296-318, 353-375, 390-412 and 434-456 550538009520 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 5.9e-40 550538009521 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.8e-43 550538009522 L,D-transpeptidase; Provisional; Region: PRK10190 550538009523 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 550538009524 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 1.2e-64 550538009525 1 probable transmembrane helix predicted for SG2039 by TMHMM2.0 at aa 7-26 550538009526 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 550538009527 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 550538009528 putative dimer interface [polypeptide binding]; other site 550538009529 active site pocket [active] 550538009530 putative cataytic base [active] 550538009531 HMMPfam hit to PF02277, Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like, core, score 1.9e-178 550538009532 cobalamin synthase; Reviewed; Region: cobS; PRK00235 550538009533 HMMPfam hit to PF02654, Cobalamin (vitamin B12) biosynthesis CobS, cobalamin-5-phosphate synthase, score 3.4e-104 550538009534 5 probable transmembrane helices predicted for SG2041 by TMHMM2.0 at aa 33-55, 59-81, 109-131, 136-158 and 185-207 550538009535 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 550538009536 homotrimer interface [polypeptide binding]; other site 550538009537 Walker A motif; other site 550538009538 GTP binding site [chemical binding]; other site 550538009539 Walker B motif; other site 550538009540 HMMPfam hit to PF02283, Cobinamide kinase/cobinamide phosphate guanyltransferase, score 5.1e-110 550538009541 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009542 cobyric acid synthase; Provisional; Region: PRK00784 550538009543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 550538009544 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 550538009545 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 550538009546 catalytic triad [active] 550538009547 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase, score 7.7e-73 550538009548 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 1.4e-61 550538009550 HMMPfam hit to PF00005, ABC transporter related, score 7e-68 550538009551 cobalt transport protein CbiQ; Provisional; Region: PRK15485 550538009552 HMMPfam hit to PF02361, Cobalt transport protein, score 3.7e-70 550538009553 4 probable transmembrane helices predicted for SG2046 by TMHMM2.0 at aa 22-47, 62-84, 91-110 and 120-142 550538009554 cobalt transport protein CbiN; Provisional; Region: PRK02898 550538009555 2 probable transmembrane helices predicted for SG2047 by TMHMM2.0 at aa 5-22 and 60-82 550538009556 HMMPfam hit to PF02553, Cobalt transport protein CbiN, score 5.4e-44 550538009557 cobalt transport protein CbiM; Validated; Region: PRK08319 550538009558 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 550538009559 HMMPfam hit to PF01891, Cobalamin (vitamin B12) biosynthesis CbiM, score 2e-107 550538009560 6 probable transmembrane helices predicted for SG2048 by TMHMM2.0 at aa 36-58, 73-95, 102-124, 134-156, 169-188 and 208-230 550538009561 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 550538009562 active site 550538009563 SAM binding site [chemical binding]; other site 550538009564 homodimer interface [polypeptide binding]; other site 550538009565 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 1.9e-64 550538009566 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 550538009567 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 550538009568 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 550538009569 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 550538009570 active site 550538009571 C-terminal domain interface [polypeptide binding]; other site 550538009572 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 550538009573 active site 550538009574 N-terminal domain interface [polypeptide binding]; other site 550538009575 HMMPfam hit to PF06180, Anaerobic cobalt chelatase, score 4.3e-166 550538009576 PS00761 Signal peptidases I signature 3. 550538009577 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 550538009578 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 550538009579 HMMPfam hit to PF02571, Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase, score 1.1e-16 550538009580 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 550538009581 active site 550538009582 SAM binding site [chemical binding]; other site 550538009583 homodimer interface [polypeptide binding]; other site 550538009584 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 5.6e-77 550538009585 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 550538009586 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 550538009587 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 550538009588 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 550538009589 HMMPfam hit to PF01890, Cobalamin (vitamin B12) biosynthesis CbiG, core, score 7.6e-163 550538009590 1 probable transmembrane helix predicted for SG2053 by TMHMM2.0 at aa 58-80 550538009591 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 550538009592 active site 550538009593 SAM binding site [chemical binding]; other site 550538009594 homodimer interface [polypeptide binding]; other site 550538009595 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 3.9e-84 550538009596 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 550538009597 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009598 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 550538009599 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 550538009600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538009601 S-adenosylmethionine binding site [chemical binding]; other site 550538009602 PS00012 Phosphopantetheine attachment site. 550538009603 HMMPfam hit to PF08242, Methyltransferase type 12, score 2e-09 550538009604 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 550538009605 active site 550538009606 putative homodimer interface [polypeptide binding]; other site 550538009607 SAM binding site [chemical binding]; other site 550538009608 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 5.9e-60 550538009609 PS00215 Mitochondrial energy transfer proteins signature. 550538009610 unknown EC_number=2.1.1.-.; the sequence has been checked and is believed to be correct 550538009611 HMMPfam hit to PF01888, Cobalamin (vitamin B12) biosynthesis CbiD, score 1.6e-182 550538009613 HMMPfam hit to PF02570, Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core, score 6.8e-39 550538009614 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 550538009615 HMMPfam hit to PF03186, Cobalamin (vitamin B12) biosynthesis CbiB, score 1.4e-185 550538009616 4 probable transmembrane helices predicted for SG2060 by TMHMM2.0 at aa 52-74, 79-101, 155-177 and 207-229 550538009617 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 550538009618 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 550538009619 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 550538009620 catalytic triad [active] 550538009621 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase, score 1.6e-51 550538009622 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 1.6e-48 550538009623 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009625 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.5e-13 550538009626 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9.6e-14 550538009627 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 550538009628 amphipathic channel; other site 550538009629 Asn-Pro-Ala signature motifs; other site 550538009630 6 probable transmembrane helices predicted for SG2064 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 143-165, 178-200 and 230-252 550538009631 HMMPfam hit to PF00230, Major intrinsic protein, score 2.9e-91 550538009632 PS00221 MIP family signature. 550538009633 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009634 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 550538009635 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 550538009636 Hexamer interface [polypeptide binding]; other site 550538009637 Putative hexagonal pore residue; other site 550538009638 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.7e-38 550538009639 PS01139 Bacterial microcompartiments proteins signature. 550538009640 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 550538009641 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 550538009642 putative hexamer interface [polypeptide binding]; other site 550538009643 putative hexagonal pore; other site 550538009644 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 550538009645 putative hexamer interface [polypeptide binding]; other site 550538009646 putative hexagonal pore; other site 550538009647 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.2e-18 550538009648 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 3.1e-19 550538009649 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 550538009650 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 550538009651 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 550538009652 alpha-beta subunit interface [polypeptide binding]; other site 550538009653 alpha-gamma subunit interface [polypeptide binding]; other site 550538009654 active site 550538009655 substrate and K+ binding site; other site 550538009656 K+ binding site [ion binding]; other site 550538009657 cobalamin binding site [chemical binding]; other site 550538009658 HMMPfam hit to PF02286, Dehydratase, large subunit, score 0 550538009659 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 550538009660 HMMPfam hit to PF02288, Dehydratase, medium subunit, score 5.5e-127 550538009661 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 550538009662 HMMPfam hit to PF02287, Dehydratase, small subunit, score 1.4e-108 550538009664 HMMPfam hit to PF08841, Diol/glycerol dehydratase reactivating factor, large subunit, score 0 550538009665 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 550538009666 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 550538009667 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 550538009668 Hexamer interface [polypeptide binding]; other site 550538009669 Putative hexagonal pore residue; other site 550538009670 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.2e-41 550538009671 PS01139 Bacterial microcompartiments proteins signature. 550538009672 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 550538009673 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 550538009674 putative hexamer interface [polypeptide binding]; other site 550538009675 putative hexagonal pore; other site 550538009676 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 1.9e-30 550538009677 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 550538009678 Propanediol utilisation protein PduL; Region: PduL; pfam06130 550538009679 Propanediol utilisation protein PduL; Region: PduL; pfam06130 550538009680 HMMPfam hit to PF06130, Propanediol utilization protein, score 3.1e-45 550538009681 HMMPfam hit to PF06130, Propanediol utilization protein, score 5.7e-36 550538009682 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 550538009683 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 550538009684 Hexamer/Pentamer interface [polypeptide binding]; other site 550538009685 central pore; other site 550538009686 HMMPfam hit to PF03319, Ethanolamine utilization protein EutN/carboxysome structural protein Ccml, score 2.2e-45 550538009688 HMMPfam hit to PF01923, Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, score 4.2e-80 550538009689 HMMPfam hit to PF03928, Protein of unknown function DUF336, score 9.1e-55 550538009690 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 550538009691 putative catalytic cysteine [active] 550538009692 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.1e-08 550538009693 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 550538009694 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 550538009695 putative active site [active] 550538009696 metal binding site [ion binding]; metal-binding site 550538009697 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.3e-94 550538009698 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538009699 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 550538009700 SLBB domain; Region: SLBB; pfam10531 550538009701 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 550538009702 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 550538009703 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit, score 7.4e-17 550538009704 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0097 550538009705 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538009706 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 550538009707 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 550538009708 putative hexamer interface [polypeptide binding]; other site 550538009709 putative hexagonal pore; other site 550538009710 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 550538009711 putative hexamer interface [polypeptide binding]; other site 550538009712 putative hexagonal pore; other site 550538009713 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 1.3e-25 550538009714 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 5.4e-32 550538009715 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 550538009716 putative hexamer interface [polypeptide binding]; other site 550538009717 putative hexagonal pore; other site 550538009718 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 4e-24 550538009719 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 550538009720 G3 box; other site 550538009721 Switch II region; other site 550538009722 GTP/Mg2+ binding site [chemical binding]; other site 550538009723 G4 box; other site 550538009724 G5 box; other site 550538009725 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009726 propionate kinase; Reviewed; Region: PRK12397 550538009727 propionate/acetate kinase; Provisional; Region: PRK12379 550538009728 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 3.4e-196 550538009729 PS01075 Acetate and butyrate kinases family signature 1. 550538009730 PS01076 Acetate and butyrate kinases family signature 2. 550538009731 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 550538009732 HMMPfam hit to PF00288, GHMP kinase, score 4.8e-10 550538009733 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 4e-05 550538009734 hypothetical protein; Provisional; Region: PRK05423 550538009735 HMMPfam hit to PF04363, Protein of unknown function DUF496, score 3.9e-69 550538009736 Predicted membrane protein [Function unknown]; Region: COG1289 550538009737 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 550538009738 6 probable transmembrane helices predicted for SG2089 by TMHMM2.0 at aa 20-42, 47-66, 73-92, 96-113, 118-135 and 140-162 550538009739 DNA gyrase inhibitor; Provisional; Region: PRK10016 550538009740 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 7.3e-35 550538009741 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 550538009742 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 550538009743 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 550538009744 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 4e-33 550538009745 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 8.8e-146 550538009746 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 550538009747 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 550538009748 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 0.00034 550538009749 5 probable transmembrane helices predicted for SG2092 by TMHMM2.0 at aa 15-37, 66-88, 93-115, 169-191 and 201-223 550538009750 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 550538009751 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1e-05 550538009752 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538009753 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0037 550538009754 thiosulfate reductase PhsA; Provisional; Region: PRK15488 550538009755 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 550538009756 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 550538009757 putative [Fe4-S4] binding site [ion binding]; other site 550538009758 putative molybdopterin cofactor binding site [chemical binding]; other site 550538009759 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538009760 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 550538009761 putative molybdopterin cofactor binding site; other site 550538009762 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 5.5e-26 550538009763 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538009764 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2e-145 550538009765 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538009766 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 5e-16 550538009767 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538009768 the sequence has been checked and is believed to be correct 550538009769 exonuclease I; Provisional; Region: sbcB; PRK11779 550538009770 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 550538009771 active site 550538009772 catalytic site [active] 550538009773 substrate binding site [chemical binding]; other site 550538009774 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 550538009775 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 2.3e-37 550538009776 HMMPfam hit to PF08411, Exonuclease C-terminal, score 9.1e-174 550538009777 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 550538009778 12 probable transmembrane helices predicted for SG2098 by TMHMM2.0 at aa 20-38, 53-75, 96-118, 133-151, 158-180, 200-219, 240-262, 289-311, 342-364, 368-385, 398-417 and 422-439 550538009779 HMMPfam hit to PF00324, Amino acid permease-associated region, score 2.1e-16 550538009780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538009781 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 550538009782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538009783 dimerization interface [polypeptide binding]; other site 550538009784 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.1e-27 550538009785 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.9e-16 550538009786 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 550538009787 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 550538009788 putative NAD(P) binding site [chemical binding]; other site 550538009789 PS00017 ATP/GTP-binding site motif A (P-loop). 550538009790 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 1.1e-05 550538009791 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 550538009792 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 550538009793 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 550538009794 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, catalytic region, score 9.6e-84 550538009795 PS01316 ATP phosphoribosyltransferase signature. 550538009796 HMMPfam hit to PF08029, Histidine biosynthesis HisG, C-terminal, score 2.3e-38 550538009797 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 550538009798 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 550538009799 NAD binding site [chemical binding]; other site 550538009800 dimerization interface [polypeptide binding]; other site 550538009801 product binding site; other site 550538009802 substrate binding site [chemical binding]; other site 550538009803 zinc binding site [ion binding]; other site 550538009804 catalytic residues [active] 550538009805 HMMPfam hit to PF00815, Histidinol dehydrogenase, score 1.2e-271 550538009806 PS00611 Histidinol dehydrogenase signature. 550538009807 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 550538009808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538009809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538009810 homodimer interface [polypeptide binding]; other site 550538009811 catalytic residue [active] 550538009812 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.4e-86 550538009813 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 550538009814 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 550538009815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538009816 active site 550538009817 motif I; other site 550538009818 motif II; other site 550538009819 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 550538009820 putative active site pocket [active] 550538009821 4-fold oligomerization interface [polypeptide binding]; other site 550538009822 metal binding residues [ion binding]; metal-binding site 550538009823 3-fold/trimer interface [polypeptide binding]; other site 550538009824 HMMPfam hit to PF08645, Polynucleotide kinase 3 phosphatase, central region, score 0.00068 550538009825 HMMPfam hit to PF00475, Imidazole glycerol-phosphate dehydratase, score 3.6e-107 550538009826 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 550538009827 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 550538009828 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 550538009829 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 550538009830 putative active site [active] 550538009831 oxyanion strand; other site 550538009832 catalytic triad [active] 550538009833 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5e-43 550538009834 PS00442 Glutamine amidotransferases class-I active site. 550538009835 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 550538009836 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 550538009837 catalytic residues [active] 550538009838 HMMPfam hit to PF00977, Histidine biosynthesis, score 1.1e-107 550538009839 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 550538009840 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 550538009841 substrate binding site [chemical binding]; other site 550538009842 glutamase interaction surface [polypeptide binding]; other site 550538009843 HMMPfam hit to PF00977, Histidine biosynthesis, score 2.7e-118 550538009844 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 550538009845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 550538009846 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 550538009847 metal binding site [ion binding]; metal-binding site 550538009848 PS00430 TonB-dependent receptor proteins signature 1. 550538009849 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 5.4e-43 550538009850 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 6.5e-48 550538009851 chain length determinant protein WzzB; Provisional; Region: PRK15471 550538009852 Chain length determinant protein; Region: Wzz; cl15801 550538009853 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 550538009854 2 probable transmembrane helices predicted for SG2109 by TMHMM2.0 at aa 33-52 and 296-315 550538009855 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 6.5e-32 550538009856 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 550538009857 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 550538009858 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 550538009859 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 550538009860 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, C-terminal, score 6.2e-05 550538009861 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, dimerisation, score 1.9e-36 550538009862 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, N-terminal, score 2.3e-41 550538009863 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 550538009864 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 550538009865 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 550538009866 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-terminal, score 2e-257 550538009867 PS00461 6-phosphogluconate dehydrogenase signature. 550538009868 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 2.1e-93 550538009869 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 550538009870 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 550538009871 Bacterial sugar transferase; Region: Bac_transf; pfam02397 550538009872 HMMPfam hit to PF02397, Bacterial sugar transferase, score 1.4e-143 550538009873 5 probable transmembrane helices predicted for SG2112 by TMHMM2.0 at aa 15-37, 57-74, 89-108, 115-134 and 282-304 550538009874 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538009875 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 550538009876 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 550538009877 active site 550538009878 substrate binding site [chemical binding]; other site 550538009879 metal binding site [ion binding]; metal-binding site 550538009880 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 3.9e-26 550538009881 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 1.6e-39 550538009882 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 2e-38 550538009883 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 8.1e-39 550538009884 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 550538009885 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 550538009886 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 550538009887 Substrate binding site; other site 550538009888 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 550538009889 HMMPfam hit to PF01050, Mannose-6-phosphate isomerase, type II, C-terminal, score 1e-124 550538009890 HMMPfam hit to PF00483, Nucleotidyl transferase, score 5.8e-145 550538009891 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 550538009892 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 550538009893 active site 550538009894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 550538009895 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 8.4e-28 550538009896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 550538009897 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 550538009898 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 8.4e-44 550538009899 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 550538009900 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 550538009901 active site 550538009902 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.6e-29 550538009903 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 550538009904 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 550538009905 12 probable transmembrane helices predicted for SG2118 by TMHMM2.0 at aa 13-32, 47-69, 90-109, 133-155, 162-184, 194-216, 229-251, 271-293, 305-327, 342-361, 374-396 and 400-422 550538009906 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 550538009907 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 550538009908 NAD binding site [chemical binding]; other site 550538009909 homotetramer interface [polypeptide binding]; other site 550538009910 homodimer interface [polypeptide binding]; other site 550538009911 active site 550538009912 substrate binding site [chemical binding]; other site 550538009913 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 5.2e-49 550538009914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 550538009915 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 550538009916 NAD(P) binding site [chemical binding]; other site 550538009917 active site 550538009918 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1e-35 550538009919 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 550538009920 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 550538009921 inhibitor-cofactor binding pocket; inhibition site 550538009922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538009923 catalytic residue [active] 550538009924 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 3.1e-173 550538009925 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 550538009926 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 550538009927 NAD binding site [chemical binding]; other site 550538009928 homotetramer interface [polypeptide binding]; other site 550538009929 homodimer interface [polypeptide binding]; other site 550538009930 substrate binding site [chemical binding]; other site 550538009931 active site 550538009932 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 5.4e-18 550538009933 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 550538009934 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 550538009935 substrate binding site; other site 550538009936 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.2e-10 550538009937 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 550538009938 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 550538009939 catalytic loop [active] 550538009940 iron binding site [ion binding]; other site 550538009941 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 550538009942 FAD binding pocket [chemical binding]; other site 550538009943 FAD binding motif [chemical binding]; other site 550538009944 phosphate binding motif [ion binding]; other site 550538009945 beta-alpha-beta structure motif; other site 550538009946 NAD binding pocket [chemical binding]; other site 550538009947 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 3.6e-37 550538009948 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 3.2e-31 550538009949 HMMPfam hit to PF00111, Ferredoxin, score 6.7e-17 550538009950 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 550538009951 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 550538009952 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase related, score 1.7e-127 550538009953 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 550538009954 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 550538009955 substrate binding site; other site 550538009956 tetramer interface; other site 550538009957 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.5e-117 550538009958 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 550538009959 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 550538009960 NADP binding site [chemical binding]; other site 550538009961 active site 550538009962 putative substrate binding site [chemical binding]; other site 550538009963 HMMPfam hit to PF04321, dTDP-4-dehydrorhamnose reductase, score 2.6e-166 550538009964 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 550538009965 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 550538009966 NAD binding site [chemical binding]; other site 550538009967 substrate binding site [chemical binding]; other site 550538009968 homodimer interface [polypeptide binding]; other site 550538009969 active site 550538009970 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 3.1e-97 550538009971 PS00061 Short-chain dehydrogenases/reductases family signature. 550538009972 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 550538009973 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 550538009974 active site 550538009975 tetramer interface; other site 550538009976 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.7e-11 550538009977 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 550538009978 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 550538009979 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 550538009980 putative ADP-binding pocket [chemical binding]; other site 550538009981 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 4.5e-46 550538009982 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 550538009983 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 550538009984 HMMPfam hit to PF04230, Polysaccharide pyruvyl transferase, score 3.8e-158 550538009985 colanic acid exporter; Provisional; Region: PRK10459 550538009986 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 550538009987 10 probable transmembrane helices predicted for SG2133 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 165-187, 286-308, 323-340, 361-383, 387-409, 416-435 and 450-472 550538009988 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 4.6e-72 550538009989 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 550538009990 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 550538009991 HMMPfam hit to PF02397, Bacterial sugar transferase, score 5.9e-43 550538009992 5 probable transmembrane helices predicted for SG2134 by TMHMM2.0 at aa 13-35, 45-64, 84-101, 111-130 and 279-300 550538009993 phosphomannomutase CpsG; Provisional; Region: PRK15414 550538009994 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 550538009995 active site 550538009996 substrate binding site [chemical binding]; other site 550538009997 metal binding site [ion binding]; metal-binding site 550538009998 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 4.4e-30 550538009999 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 4.5e-54 550538010000 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 2.7e-55 550538010001 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 2e-51 550538010002 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 550538010003 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 550538010004 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 550538010005 Substrate binding site; other site 550538010006 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 550538010007 HMMPfam hit to PF01050, Mannose-6-phosphate isomerase, type II, C-terminal, score 4.9e-134 550538010008 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.9e-136 550538010009 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 550538010010 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 550538010011 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1.6e-18 550538010012 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 550538010013 active site 550538010014 GDP-Mannose binding site [chemical binding]; other site 550538010015 dimer interface [polypeptide binding]; other site 550538010016 modified nudix motif 550538010017 metal binding site [ion binding]; metal-binding site 550538010018 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 3e-24 550538010019 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 550538010020 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 550538010021 NADP binding site [chemical binding]; other site 550538010022 active site 550538010023 putative substrate binding site [chemical binding]; other site 550538010024 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.5e-92 550538010025 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 550538010026 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 550538010027 NADP-binding site; other site 550538010028 homotetramer interface [polypeptide binding]; other site 550538010029 substrate binding site [chemical binding]; other site 550538010030 homodimer interface [polypeptide binding]; other site 550538010031 active site 550538010032 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.1e-110 550538010033 PS00061 Short-chain dehydrogenases/reductases family signature. 550538010034 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 550538010035 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 550538010036 putative trimer interface [polypeptide binding]; other site 550538010037 putative active site [active] 550538010038 putative substrate binding site [chemical binding]; other site 550538010039 putative CoA binding site [chemical binding]; other site 550538010040 PS00101 Hexapeptide-repeat containing-transferases signature. 550538010041 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.16 550538010042 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.1e+02 550538010043 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.15 550538010044 putative glycosyl transferase; Provisional; Region: PRK10063 550538010045 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 550538010046 metal-binding site 550538010047 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.9e-19 550538010048 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 550538010049 12 probable transmembrane helices predicted for SG2144 by TMHMM2.0 at aa 7-25, 30-47, 54-76, 81-103, 116-138, 143-165, 172-189, 204-226, 246-268, 283-305, 326-348 and 368-390 550538010050 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 550538010051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 550538010052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 550538010053 putative acyl transferase; Provisional; Region: PRK10191 550538010054 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 550538010055 trimer interface [polypeptide binding]; other site 550538010056 active site 550538010057 substrate binding site [chemical binding]; other site 550538010058 CoA binding site [chemical binding]; other site 550538010059 PS00101 Hexapeptide-repeat containing-transferases signature. 550538010060 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.17 550538010061 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 29 550538010062 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.1e+02 550538010063 putative glycosyl transferase; Provisional; Region: PRK10018 550538010064 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 550538010065 active site 550538010066 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.5e-30 550538010067 tyrosine kinase; Provisional; Region: PRK11519 550538010068 Chain length determinant protein; Region: Wzz; pfam02706 550538010069 Chain length determinant protein; Region: Wzz; cl15801 550538010070 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 550538010071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 550538010072 2 probable transmembrane helices predicted for SG2148 by TMHMM2.0 at aa 31-53 and 426-448 550538010073 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 1.2e-89 550538010074 Low molecular weight phosphatase family; Region: LMWPc; cd00115 550538010075 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 550538010076 active site 550538010077 HMMPfam hit to PF01451, Protein-tyrosine phosphatase, low molecular weight, score 1.4e-60 550538010078 polysaccharide export protein Wza; Provisional; Region: PRK15078 550538010079 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 550538010080 HMMPfam hit to PF02563, Polysaccharide export protein, score 9.7e-68 550538010081 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 550538010082 FOG: CBS domain [General function prediction only]; Region: COG0517 550538010083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 550538010084 Transporter associated domain; Region: CorC_HlyC; smart01091 550538010085 HMMPfam hit to PF03741, Integral membrane protein TerC, score 4.2e-35 550538010086 7 probable transmembrane helices predicted for SG2151 by TMHMM2.0 at aa 13-35, 48-70, 80-99, 126-148, 153-172, 185-207 and 212-234 550538010087 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 3.5e-24 550538010088 HMMPfam hit to PF03471, Transporter-associated region, score 5.9e-23 550538010089 putative assembly protein; Provisional; Region: PRK10833 550538010090 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 550538010091 HMMPfam hit to PF05170, AsmA, score 1.2e-138 550538010092 1 probable transmembrane helix predicted for SG2152 by TMHMM2.0 at aa 7-26 550538010093 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 550538010094 trimer interface [polypeptide binding]; other site 550538010095 active site 550538010096 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 0.00056 550538010097 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 550538010098 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 550538010099 ATP-binding site [chemical binding]; other site 550538010100 Sugar specificity; other site 550538010101 Pyrimidine base specificity; other site 550538010102 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 1.6e-50 550538010103 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010104 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 550538010105 PAS domain S-box; Region: sensory_box; TIGR00229 550538010106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538010107 putative active site [active] 550538010108 heme pocket [chemical binding]; other site 550538010109 PAS domain S-box; Region: sensory_box; TIGR00229 550538010110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538010111 putative active site [active] 550538010112 heme pocket [chemical binding]; other site 550538010113 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 550538010114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538010115 metal binding site [ion binding]; metal-binding site 550538010116 active site 550538010117 I-site; other site 550538010118 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538010119 10 probable transmembrane helices predicted for SG2155 by TMHMM2.0 at aa 15-37, 64-86, 90-112, 124-146, 156-177, 189-208, 212-229, 236-258, 268-290 and 310-327 550538010120 HMMPfam hit to PF05231, MASE1, score 1.2e-59 550538010121 HMMPfam hit to PF08447, PAS fold-3, score 1.8e-07 550538010122 HMMPfam hit to PF08448, PAS fold-4, score 3.7e-11 550538010123 HMMPfam hit to PF00990, GGDEF, score 1.1e-63 550538010124 HMMPfam hit to PF00563, EAL, score 9e-09 550538010125 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 550538010126 AlkA N-terminal domain; Region: AlkA_N; pfam06029 550538010127 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 550538010128 minor groove reading motif; other site 550538010129 helix-hairpin-helix signature motif; other site 550538010130 substrate binding pocket [chemical binding]; other site 550538010131 active site 550538010132 HMMPfam hit to PF00730, HhH-GPD, score 4e-16 550538010133 PS00516 Alkylbase DNA glycosidases alkA family signature. 550538010134 HMMPfam hit to PF06029, AlkA, N-terminal, score 7.9e-65 550538010135 putative chaperone; Provisional; Region: PRK11678 550538010136 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 550538010137 nucleotide binding site [chemical binding]; other site 550538010138 putative NEF/HSP70 interaction site [polypeptide binding]; other site 550538010139 SBD interface [polypeptide binding]; other site 550538010140 PS00329 Heat shock hsp70 proteins family signature 2. 550538010141 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 550538010142 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538010143 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538010144 1 probable transmembrane helix predicted for SG2158 by TMHMM2.0 at aa 7-26 550538010145 HMMPfam hit to PF00529, Secretion protein HlyD, score 6.2e-25 550538010146 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 550538010147 Protein export membrane protein; Region: SecD_SecF; cl14618 550538010148 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 550538010149 11 probable transmembrane helices predicted for SG2159 by TMHMM2.0 at aa 15-37, 345-362, 367-389, 396-418, 438-460, 472-494, 535-557, 867-889, 909-931, 968-990 and 1000-1022 550538010150 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 550538010151 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 550538010152 10 probable transmembrane helices predicted for SG2160 by TMHMM2.0 at aa 7-29, 336-353, 360-382, 434-456, 463-485, 525-547, 853-875, 895-917, 948-970 and 985-1007 550538010154 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.1e-51 550538010155 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 550538010156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538010157 dimerization interface [polypeptide binding]; other site 550538010158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538010159 dimer interface [polypeptide binding]; other site 550538010160 phosphorylation site [posttranslational modification] 550538010161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538010162 ATP binding site [chemical binding]; other site 550538010163 Mg2+ binding site [ion binding]; other site 550538010164 G-X-G motif; other site 550538010165 2 probable transmembrane helices predicted for SG2163 by TMHMM2.0 at aa 13-35 and 168-190 550538010166 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 5.8e-20 550538010167 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.6e-16 550538010168 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.4e-35 550538010169 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 550538010170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538010171 active site 550538010172 phosphorylation site [posttranslational modification] 550538010173 intermolecular recognition site; other site 550538010174 dimerization interface [polypeptide binding]; other site 550538010175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538010176 DNA binding site [nucleotide binding] 550538010177 HMMPfam hit to PF00072, Response regulator receiver, score 2.2e-30 550538010178 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.6e-22 550538010179 PS00294 Prenyl group binding site (CAAX box). 550538010180 PcfJ-like protein; Region: PcfJ; pfam14284 550538010181 the sequence has been checked and is believed to be correct 550538010182 the sequence has been checked and is believed to be correct 550538010183 putative protease; Provisional; Region: PRK15452 550538010184 Peptidase family U32; Region: Peptidase_U32; pfam01136 550538010185 HMMPfam hit to PF01136, Peptidase U32, score 2.7e-150 550538010186 PS01276 Peptidase family U32 signature. 550538010187 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 550538010188 HMMPfam hit to PF05932, Tir chaperone, score 5.6e-38 550538010189 2 probable transmembrane helices predicted for SG2171 by TMHMM2.0 at aa 42-64 and 79-101 550538010190 1 probable transmembrane helix predicted for SG2172 by TMHMM2.0 at aa 5-24 550538010191 lipid kinase; Reviewed; Region: PRK13054 550538010192 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 550538010193 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 1.5e-33 550538010194 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 550538010195 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 550538010196 putative active site; other site 550538010197 catalytic residue [active] 550538010198 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 3.7e-85 550538010199 nucleoside transporter; Region: 2A0110; TIGR00889 550538010200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010201 putative substrate translocation pore; other site 550538010202 HMMPfam hit to PF03825, Nucleoside:H+ symporter, score 7.1e-280 550538010203 12 probable transmembrane helices predicted for SG2175 by TMHMM2.0 at aa 7-29, 39-61, 70-87, 97-119, 132-154, 159-181, 211-233, 243-265, 274-293, 297-319, 339-358 and 378-400 550538010204 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 550538010205 HMMPfam hit to PF03747, ADP-ribosylation/Crystallin J1, score 8.7e-99 550538010206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538010207 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 550538010208 substrate binding site [chemical binding]; other site 550538010209 ATP binding site [chemical binding]; other site 550538010210 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 7.5e-47 550538010211 PS00583 pfkB family of carbohydrate kinases signature 1. 550538010212 PS00584 pfkB family of carbohydrate kinases signature 2. 550538010213 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 550538010214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538010215 DNA-binding site [nucleotide binding]; DNA binding site 550538010216 UTRA domain; Region: UTRA; pfam07702 550538010217 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 6.9e-45 550538010218 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.9e-18 550538010219 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 550538010220 dimer interface [polypeptide binding]; other site 550538010221 substrate binding site [chemical binding]; other site 550538010222 ATP binding site [chemical binding]; other site 550538010223 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase type-1, score 2.1e-144 550538010224 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 550538010225 substrate binding site [chemical binding]; other site 550538010226 multimerization interface [polypeptide binding]; other site 550538010227 ATP binding site [chemical binding]; other site 550538010228 HMMPfam hit to PF02110, Hydroxyethylthiazole kinase, score 8.7e-153 550538010229 Predicted integral membrane protein [Function unknown]; Region: COG5455 550538010230 fimbrial operon peg 550538010231 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 550538010232 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 550538010234 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 9.5e-284 550538010235 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 550538010236 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538010237 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.1e-07 550538010238 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 4.8e-60 550538010239 PS00635 Gram-negative pili assembly chaperone signature. 550538010240 1 probable transmembrane helix predicted for SG2185 by TMHMM2.0 at aa 20-42 550538010241 fimbrial chaperone protein; Provisional; Region: PRK15220 550538010242 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0014 550538010243 PS00237 G-protein coupled receptors signature. 550538010244 1 probable transmembrane helix predicted for SG2186 by TMHMM2.0 at aa 5-22 550538010245 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 550538010246 antiporter inner membrane protein; Provisional; Region: PRK11670 550538010247 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 550538010248 Walker A motif; other site 550538010249 PS01215 Mrp family signature. 550538010250 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010251 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 550538010252 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 550538010253 active site 550538010254 HIGH motif; other site 550538010255 KMSKS motif; other site 550538010256 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 550538010257 tRNA binding surface [nucleotide binding]; other site 550538010258 anticodon binding site; other site 550538010259 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 550538010260 dimer interface [polypeptide binding]; other site 550538010261 putative tRNA-binding site [nucleotide binding]; other site 550538010262 HMMPfam hit to PF09334, Aminoacyl-tRNA synthetase, class I (M), score 2.7e-235 550538010263 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538010264 HMMPfam hit to PF01588, tRNA-binding region, score 3.9e-41 550538010265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 550538010266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538010267 HMMPfam hit to PF06998, Protein of unknown function DUF1307, score 1.4e-75 550538010269 HMMPfam hit to PF06998, Protein of unknown function DUF1307, score 7.1e-80 550538010270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 550538010271 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 550538010272 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 550538010273 HMMPfam hit to PF07308, Protein of unknown function DUF1456, score 1.7e-32 550538010274 HMMPfam hit to PF07308, Protein of unknown function DUF1456, score 1.5e-34 550538010275 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 550538010276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538010277 active site 550538010278 phosphorylation site [posttranslational modification] 550538010279 intermolecular recognition site; other site 550538010280 dimerization interface [polypeptide binding]; other site 550538010281 LytTr DNA-binding domain; Region: LytTR; pfam04397 550538010282 HMMPfam hit to PF04397, LytTr DNA-binding region, score 2.1e-27 550538010283 HMMPfam hit to PF00072, Response regulator receiver, score 3.7e-41 550538010284 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 550538010285 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 550538010286 GAF domain; Region: GAF; pfam01590 550538010287 Histidine kinase; Region: His_kinase; pfam06580 550538010288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538010289 ATP binding site [chemical binding]; other site 550538010290 Mg2+ binding site [ion binding]; other site 550538010291 G-X-G motif; other site 550538010292 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.8e-15 550538010293 HMMPfam hit to PF06580, Histidine kinase internal region, score 5e-43 550538010294 HMMPfam hit to PF01590, GAF, score 0.00055 550538010295 6 probable transmembrane helices predicted for SG2195 by TMHMM2.0 at aa 4-23, 44-63, 73-95, 107-129, 139-161 and 168-190 550538010296 HMMPfam hit to PF07694, 5TM Receptors of the LytS-YhcK type, transmembrane region, score 4.7e-41 550538010297 transcriptional regulator MirA; Provisional; Region: PRK15043 550538010298 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 550538010299 DNA binding residues [nucleotide binding] 550538010300 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 4.9e-12 550538010301 PS00552 Bacterial regulatory proteins, merR family signature. 550538010302 hypothetical protein; Provisional; Region: PRK13681 550538010303 1 probable transmembrane helix predicted for SG2197 by TMHMM2.0 at aa 7-29 550538010304 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 550538010305 putative PBP binding loops; other site 550538010306 ABC-ATPase subunit interface; other site 550538010307 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-28 550538010308 6 probable transmembrane helices predicted for SG2198 by TMHMM2.0 at aa 7-29, 51-73, 86-108, 118-140, 180-202 and 212-231 550538010309 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 550538010310 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 550538010311 Walker A/P-loop; other site 550538010312 ATP binding site [chemical binding]; other site 550538010313 Q-loop/lid; other site 550538010314 ABC transporter signature motif; other site 550538010315 Walker B; other site 550538010316 D-loop; other site 550538010317 H-loop/switch region; other site 550538010318 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 550538010319 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 3.1e-05 550538010320 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-57 550538010321 PS00211 ABC transporters family signature. 550538010322 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538010324 dimer interface [polypeptide binding]; other site 550538010325 conserved gate region; other site 550538010326 ABC-ATPase subunit interface; other site 550538010327 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.6e-28 550538010328 10 probable transmembrane helices predicted for SG2200 by TMHMM2.0 at aa 13-33, 48-70, 75-97, 107-126, 139-161, 186-208, 215-237, 252-274, 328-350 and 360-382 550538010329 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538010330 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538010331 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 550538010332 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 5.6e-81 550538010333 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 550538010334 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 550538010335 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 550538010336 HMMPfam hit to PF01915, Glycoside hydrolase, family 3, C-terminal, score 4e-99 550538010337 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 5.3e-109 550538010338 PS00775 Glycosyl hydrolases family 3 active site. 550538010339 D-lactate dehydrogenase; Provisional; Region: PRK11183 550538010340 FAD binding domain; Region: FAD_binding_4; pfam01565 550538010341 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 550538010342 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 8.3e-11 550538010343 HMMPfam hit to PF09330, D-lactate dehydrogenase, membrane binding, C-terminal, score 7.6e-234 550538010344 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 550538010345 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 550538010346 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 550538010347 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 2.2e-123 550538010348 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 550538010349 HMMPfam hit to PF06930, Protein of unknown function DUF1282, score 1.1e-134 550538010350 5 probable transmembrane helices predicted for SG2205 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 135-157 and 170-192 550538010351 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 550538010352 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 550538010353 5 probable transmembrane helices predicted for SG2206 by TMHMM2.0 at aa 21-43, 53-72, 100-122, 137-159 and 172-189 550538010354 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 9.2e-06 550538010356 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.4e-24 550538010357 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 550538010358 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.5e-39 550538010359 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.2e-16 550538010360 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538010361 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 550538010362 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 550538010363 FMN binding site [chemical binding]; other site 550538010364 active site 550538010365 catalytic residues [active] 550538010366 substrate binding site [chemical binding]; other site 550538010367 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 1e-132 550538010368 PS01136 Uncharacterized protein family UPF0034 signature. 550538010369 salicylate hydroxylase; Provisional; Region: PRK08163 550538010370 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 550538010371 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.9e-09 550538010372 1 probable transmembrane helix predicted for SG2211 by TMHMM2.0 at aa 7-24 550538010373 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 550538010374 maleylacetoacetate isomerase; Region: maiA; TIGR01262 550538010375 C-terminal domain interface [polypeptide binding]; other site 550538010376 GSH binding site (G-site) [chemical binding]; other site 550538010377 putative dimer interface [polypeptide binding]; other site 550538010378 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 550538010379 dimer interface [polypeptide binding]; other site 550538010380 N-terminal domain interface [polypeptide binding]; other site 550538010381 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 550538010382 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 5.1e-05 550538010383 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 5.9e-12 550538010384 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 550538010385 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 550538010386 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 3.3e-57 550538010387 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 550538010388 Cupin domain; Region: Cupin_2; pfam07883 550538010389 Cupin domain; Region: Cupin_2; pfam07883 550538010390 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 0.0012 550538010391 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.9e-22 550538010392 benzoate transport; Region: 2A0115; TIGR00895 550538010393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010394 putative substrate translocation pore; other site 550538010395 12 probable transmembrane helices predicted for SG2215 by TMHMM2.0 at aa 23-45, 60-82, 89-108, 113-135, 148-170, 175-197, 253-275, 290-312, 319-338, 342-364, 385-407 and 412-434 550538010396 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5.7e-53 550538010398 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.8e-17 550538010399 HMMPfam hit to PF03466, LysR, substrate-binding, score 9.7e-09 550538010400 hypothetical protein; Provisional; Region: PRK01821 550538010401 4 probable transmembrane helices predicted for SG2217 by TMHMM2.0 at aa 7-29, 34-56, 63-85 and 95-117 550538010402 HMMPfam hit to PF03788, LrgA, score 1e-56 550538010403 hypothetical protein; Provisional; Region: PRK10711 550538010404 5 probable transmembrane helices predicted for SG2218 by TMHMM2.0 at aa 5-24, 34-56, 91-113, 140-162 and 206-228 550538010405 HMMPfam hit to PF04172, LrgB-like protein, score 1.8e-122 550538010406 cytidine deaminase; Provisional; Region: PRK09027 550538010407 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 550538010408 active site 550538010409 catalytic motif [active] 550538010410 Zn binding site [ion binding]; other site 550538010411 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 550538010412 active site 550538010413 catalytic motif [active] 550538010414 Zn binding site [ion binding]; other site 550538010415 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 7.4e-23 550538010416 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 550538010417 HMMPfam hit to PF08211, Cytidine and deoxycytidylate deaminase, zinc-binding region, score 7.5e-75 550538010418 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 550538010419 putative active site [active] 550538010420 1 probable transmembrane helix predicted for SG2220 by TMHMM2.0 at aa 5-27 550538010421 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 1.4e-39 550538010422 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 550538010423 2 probable transmembrane helices predicted for SG2221 by TMHMM2.0 at aa 7-26 and 57-79 550538010424 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 550538010425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 550538010426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538010427 PS00190 Cytochrome c family heme-binding site signature. 550538010428 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2e-09 550538010429 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 6.1e-09 550538010430 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 550538010431 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 550538010432 homodimer interface [polypeptide binding]; other site 550538010433 active site 550538010434 FMN binding site [chemical binding]; other site 550538010435 substrate binding site [chemical binding]; other site 550538010436 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, core, score 3.2e-18 550538010437 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00052 550538010438 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00015 550538010439 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 550538010441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 550538010442 TM-ABC transporter signature motif; other site 550538010443 9 probable transmembrane helices predicted for SG2224 by TMHMM2.0 at aa 20-42, 49-68, 100-122, 127-149, 179-201, 222-244, 259-281, 286-308 and 312-330 550538010444 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 4.6e-65 550538010446 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-21 550538010447 HMMPfam hit to PF00005, ABC transporter related, score 4.7e-41 550538010448 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 550538010449 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 550538010450 ligand binding site [chemical binding]; other site 550538010451 calcium binding site [ion binding]; other site 550538010452 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 0.00088 550538010453 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010454 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 550538010455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538010456 DNA binding site [nucleotide binding] 550538010457 domain linker motif; other site 550538010458 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 550538010459 dimerization interface (closed form) [polypeptide binding]; other site 550538010460 ligand binding site [chemical binding]; other site 550538010461 PS00134 Serine proteases, trypsin family, histidine active site. 550538010462 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.5e-13 550538010463 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 7.9e-13 550538010464 PS00356 Bacterial regulatory proteins, lacI family signature. 550538010465 Predicted membrane protein [Function unknown]; Region: COG2311 550538010466 hypothetical protein; Provisional; Region: PRK10835 550538010467 HMMPfam hit to PF04235, Protein of unknown function DUF418, score 3.3e-57 550538010468 9 probable transmembrane helices predicted for SG2229 by TMHMM2.0 at aa 12-34, 49-71, 83-102, 107-123, 130-152, 199-221, 233-255, 308-330 and 337-359 550538010469 HMMPfam hit to PF04171, Protein of unknown function DUF405, score 2e-61 550538010470 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 550538010471 GTP cyclohydrolase I; Provisional; Region: PLN03044 550538010472 active site 550538010473 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 4.7e-56 550538010474 PS00860 GTP cyclohydrolase I signature 2. 550538010475 PS00859 GTP cyclohydrolase I signature 1. 550538010476 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 550538010477 S-formylglutathione hydrolase; Region: PLN02442 550538010478 HMMPfam hit to PF00756, esterase, score 1.6e-110 550538010479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538010480 non-specific DNA binding site [nucleotide binding]; other site 550538010481 salt bridge; other site 550538010482 sequence-specific DNA binding site [nucleotide binding]; other site 550538010483 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.8e-09 550538010484 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 550538010485 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 550538010486 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 550538010487 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 8.9e-148 550538010488 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 4.7e-22 550538010489 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 550538010490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 550538010491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538010492 motif II; other site 550538010493 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.2e-17 550538010494 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 550538010495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010496 putative substrate translocation pore; other site 550538010497 11 probable transmembrane helices predicted for SG2235 by TMHMM2.0 at aa 29-46, 69-91, 103-125, 160-182, 189-208, 240-262, 295-314, 324-343, 348-370, 385-407 and 412-434 550538010498 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.5e-51 550538010499 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 550538010500 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 550538010501 N-terminal plug; other site 550538010502 ligand-binding site [chemical binding]; other site 550538010503 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 3e-30 550538010504 PS01156 TonB-dependent receptor proteins signature 2. 550538010505 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 2.3e-33 550538010506 PS00430 TonB-dependent receptor proteins signature 1. 550538010507 lysine transporter; Provisional; Region: PRK10836 550538010508 HMMPfam hit to PF00324, Amino acid permease-associated region, score 6.8e-204 550538010509 12 probable transmembrane helices predicted for SG2237 by TMHMM2.0 at aa 21-43, 53-75, 103-125, 130-152, 159-181, 196-218, 245-267, 287-309, 343-365, 369-391, 412-434 and 444-466 550538010510 PS00218 Amino acid permeases signature. 550538010511 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 550538010512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538010513 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 550538010514 putative dimerization interface [polypeptide binding]; other site 550538010515 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.7e-55 550538010516 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-18 550538010517 PS00044 Bacterial regulatory proteins, lysR family signature. 550538010518 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 550538010519 8 probable transmembrane helices predicted for SG2239 by TMHMM2.0 at aa 13-35, 39-61, 100-122, 132-151, 163-185, 262-284, 291-313 and 323-345 550538010520 HMMPfam hit to PF03601, Conserved hypothetical protein CHP00698, score 1e-169 550538010521 endonuclease IV; Provisional; Region: PRK01060 550538010522 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 550538010523 AP (apurinic/apyrimidinic) site pocket; other site 550538010524 DNA interaction; other site 550538010525 Metal-binding active site; metal-binding site 550538010526 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 9.4e-65 550538010527 PS00729 AP endonucleases family 2 signature 1. 550538010528 PS00730 AP endonucleases family 2 signature 2. 550538010529 PS00731 AP endonucleases family 2 signature 3. 550538010530 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 550538010531 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 550538010532 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 550538010533 active site 550538010534 P-loop; other site 550538010535 phosphorylation site [posttranslational modification] 550538010536 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 550538010537 9 probable transmembrane helices predicted for SG2241 by TMHMM2.0 at aa 236-258, 271-293, 303-325, 345-367, 377-399, 412-434, 464-481, 488-508 and 528-550 550538010538 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 9.4e-20 550538010539 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 2e-61 550538010540 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 550538010541 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 550538010542 putative substrate binding site [chemical binding]; other site 550538010543 putative ATP binding site [chemical binding]; other site 550538010544 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.8e-71 550538010545 PS00584 pfkB family of carbohydrate kinases signature 2. 550538010546 PS00583 pfkB family of carbohydrate kinases signature 1. 550538010547 PS00464 Ribosomal protein L22 signature. 550538010548 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 550538010549 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538010550 active site 550538010551 phosphorylation site [posttranslational modification] 550538010552 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 550538010553 dimerization domain swap beta strand [polypeptide binding]; other site 550538010554 regulatory protein interface [polypeptide binding]; other site 550538010555 active site 550538010556 regulatory phosphorylation site [posttranslational modification]; other site 550538010557 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 2.2e-52 550538010558 PS00589 PTS HPR component serine phosphorylation site signature. 550538010559 PS00369 PTS HPR component histidine phosphorylation site signature. 550538010560 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 5.1e-73 550538010561 PS00372 PTS EIIA domains phosphorylation site signature 2. 550538010562 sugar efflux transporter B; Provisional; Region: PRK15011 550538010563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010564 putative substrate translocation pore; other site 550538010565 12 probable transmembrane helices predicted for SG2244 by TMHMM2.0 at aa 20-42, 52-71, 84-101, 105-124, 145-167, 172-194, 221-243, 253-275, 282-304, 308-330, 350-367 and 371-390 550538010566 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.3e-38 550538010567 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 550538010568 2 probable transmembrane helices predicted for SG2245 by TMHMM2.0 at aa 21-43 and 184-203 550538010569 1 probable transmembrane helix predicted for SG2246 by TMHMM2.0 at aa 12-34 550538010570 elongation factor P; Provisional; Region: PRK04542 550538010571 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 550538010572 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 550538010573 RNA binding site [nucleotide binding]; other site 550538010574 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 550538010575 RNA binding site [nucleotide binding]; other site 550538010576 HMMPfam hit to PF08207, Translation elongation factor, KOW-like, score 6.3e-29 550538010577 HMMPfam hit to PF01132, Translation elongation factor P/YeiP, central, score 3.5e-30 550538010578 HMMPfam hit to PF09285, Elongation factor P, C-terminal, score 7.5e-29 550538010579 PS01275 Elongation factor P signature. 550538010580 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 550538010581 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 550538010582 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 550538010583 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 2.4e-45 550538010584 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010585 HMMPfam hit to PF07683, Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal, score 1.2e-08 550538010586 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 550538010587 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 550538010588 active site 550538010589 5 probable transmembrane helices predicted for SG2251 by TMHMM2.0 at aa 7-26, 64-83, 95-117, 162-184 and 191-213 550538010590 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 1.1e-17 550538010591 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 550538010592 NlpC/P60 family; Region: NLPC_P60; pfam00877 550538010593 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538010594 HMMPfam hit to PF00877, NLP/P60, score 1.3e-54 550538010595 the sequence has been checked and is believed to be correct 550538010596 HMMPfam hit to PF00563, EAL, score 3.6e-102 550538010597 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 550538010598 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 550538010599 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 8.2e-56 550538010600 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 550538010601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538010602 dimer interface [polypeptide binding]; other site 550538010603 conserved gate region; other site 550538010604 putative PBP binding loops; other site 550538010605 ABC-ATPase subunit interface; other site 550538010606 6 probable transmembrane helices predicted for SG2255 by TMHMM2.0 at aa 9-31, 133-155, 168-190, 224-246, 283-305 and 329-348 550538010607 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-58 550538010608 microcin C ABC transporter permease; Provisional; Region: PRK15021 550538010609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538010610 dimer interface [polypeptide binding]; other site 550538010611 conserved gate region; other site 550538010612 ABC-ATPase subunit interface; other site 550538010613 6 probable transmembrane helices predicted for SG2256 by TMHMM2.0 at aa 21-43, 142-164, 177-199, 203-222, 254-276 and 306-328 550538010614 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.1e-46 550538010615 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538010616 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 550538010617 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538010618 Walker A/P-loop; other site 550538010619 ATP binding site [chemical binding]; other site 550538010620 Q-loop/lid; other site 550538010621 ABC transporter signature motif; other site 550538010622 Walker B; other site 550538010623 D-loop; other site 550538010624 H-loop/switch region; other site 550538010625 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 550538010626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538010627 Walker A/P-loop; other site 550538010628 ATP binding site [chemical binding]; other site 550538010629 Q-loop/lid; other site 550538010630 ABC transporter signature motif; other site 550538010631 Walker B; other site 550538010632 D-loop; other site 550538010633 H-loop/switch region; other site 550538010634 HMMPfam hit to PF00005, ABC transporter related, score 9.2e-62 550538010635 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010636 PS00211 ABC transporters family signature. 550538010637 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 0.00017 550538010638 HMMPfam hit to PF00005, ABC transporter related, score 4e-58 550538010639 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010640 PS00211 ABC transporters family signature. 550538010641 hypothetical protein; Provisional; Region: PRK11835 550538010642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010643 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 550538010644 putative substrate translocation pore; other site 550538010645 12 probable transmembrane helices predicted for SG2259 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 286-308, 313-332, 345-367 and 372-391 550538010646 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.2e-57 550538010647 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 550538010648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538010649 RNA binding surface [nucleotide binding]; other site 550538010650 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 550538010651 active site 550538010652 uracil binding [chemical binding]; other site 550538010653 HMMPfam hit to PF00849, Pseudouridine synthase, score 3.5e-28 550538010654 PS01149 Rsu family of pseudouridine synthase signature. 550538010655 HMMPfam hit to PF01479, RNA-binding S4, score 3.8e-09 550538010656 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 550538010657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538010658 ATP binding site [chemical binding]; other site 550538010659 putative Mg++ binding site [ion binding]; other site 550538010660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538010661 nucleotide binding region [chemical binding]; other site 550538010662 ATP-binding site [chemical binding]; other site 550538010663 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 550538010664 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 3.8e-41 550538010665 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 3.2e-14 550538010666 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010667 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 550538010668 5S rRNA interface [nucleotide binding]; other site 550538010669 CTC domain interface [polypeptide binding]; other site 550538010670 L16 interface [polypeptide binding]; other site 550538010671 HMMPfam hit to PF01386, Ribosomal protein L25, score 1.6e-49 550538010672 2 probable transmembrane helices predicted for SG2263 by TMHMM2.0 at aa 2-20 and 24-46 550538010673 Nucleoid-associated protein [General function prediction only]; Region: COG3081 550538010674 nucleoid-associated protein NdpA; Validated; Region: PRK00378 550538010675 HMMPfam hit to PF04245, 37kDa nucleoid-associated bacterial protein, score 9.4e-173 550538010676 hypothetical protein; Provisional; Region: PRK13689 550538010677 HMMPfam hit to PF07208, Protein of unknown function DUF1414, score 3.1e-50 550538010678 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 550538010679 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 550538010680 Sulfatase; Region: Sulfatase; cl17466 550538010681 PS00430 TonB-dependent receptor proteins signature 1. 550538010682 5 probable transmembrane helices predicted for SG2266 by TMHMM2.0 at aa 21-43, 58-80, 85-103, 135-157 and 169-191 550538010683 HMMPfam hit to PF00884, Sulphatase, score 9.2e-64 550538010685 the sequence has been checked and is believed to be correct 550538010686 HMMPfam hit to PF00560, Leucine-rich repeat, score 3.6 550538010687 HMMPfam hit to PF00560, Leucine-rich repeat, score 5.7 550538010688 HMMPfam hit to PF00560, Leucine-rich repeat, score 1.7 550538010689 HMMPfam hit to PF00560, Leucine-rich repeat, score 1.7 550538010690 HMMPfam hit to PF00560, Leucine-rich repeat, score 3 550538010692 the sequence has been checked and is believed to be correct 550538010693 HMMPfam hit to PF03406, Phage tail fiber repeat 2, score 1.6e-15 550538010694 DinI-like family; Region: DinI; cl11630 550538010695 HMMPfam hit to PF06183, DinI-like, score 5.9e-05 550538010696 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 550538010697 2 probable transmembrane helices predicted for SG2273 by TMHMM2.0 at aa 7-26 and 108-126 550538010698 transcriptional regulator NarP; Provisional; Region: PRK10403 550538010699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538010700 active site 550538010701 phosphorylation site [posttranslational modification] 550538010702 intermolecular recognition site; other site 550538010703 dimerization interface [polypeptide binding]; other site 550538010704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538010705 DNA binding residues [nucleotide binding] 550538010706 dimerization interface [polypeptide binding]; other site 550538010707 HMMPfam hit to PF00072, Response regulator receiver, score 5.5e-37 550538010708 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.6e-29 550538010709 PS00622 Bacterial regulatory proteins, luxR family signature. 550538010710 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 550538010711 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 550538010712 2 probable transmembrane helices predicted for SG2275 by TMHMM2.0 at aa 106-128 and 153-175 550538010713 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 2.8e-68 550538010714 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 550538010715 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 550538010716 catalytic residues [active] 550538010717 central insert; other site 550538010718 HMMPfam hit to PF08534, Redoxin, score 2.5e-27 550538010719 PS00194 Thioredoxin family active site. 550538010720 1 probable transmembrane helix predicted for SG2276 by TMHMM2.0 at aa 5-24 550538010721 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 550538010722 15 probable transmembrane helices predicted for SG2277 by TMHMM2.0 at aa 5-27, 40-62, 95-114, 121-143, 176-198, 211-233, 248-265, 277-299, 314-332, 353-375, 390-412, 425-444, 449-468, 481-503 and 610-629 550538010723 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 1.3e-82 550538010724 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 550538010725 HMMPfam hit to PF03100, CcmE/CycJ protein, score 4.6e-91 550538010726 1 probable transmembrane helix predicted for SG2278 by TMHMM2.0 at aa 7-29 550538010727 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 550538010728 HMMPfam hit to PF04995, Heme exporter protein D (CcmD), score 2.7e-16 550538010729 1 probable transmembrane helix predicted for SG2279 by TMHMM2.0 at aa 15-37 550538010730 heme exporter protein CcmC; Region: ccmC; TIGR01191 550538010731 6 probable transmembrane helices predicted for SG2280 by TMHMM2.0 at aa 21-43, 63-85, 92-114, 129-148, 155-177 and 204-226 550538010732 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 1.4e-56 550538010733 heme exporter protein CcmB; Region: ccmB; TIGR01190 550538010734 HMMPfam hit to PF03379, Cytochrome c-type biogenesis protein CcmB, score 2.5e-111 550538010735 6 probable transmembrane helices predicted for SG2281 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 128-150, 157-179 and 194-216 550538010736 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 550538010737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538010738 Walker A/P-loop; other site 550538010739 ATP binding site [chemical binding]; other site 550538010740 Q-loop/lid; other site 550538010741 ABC transporter signature motif; other site 550538010742 Walker B; other site 550538010743 D-loop; other site 550538010744 H-loop/switch region; other site 550538010745 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-48 550538010746 PS00211 ABC transporters family signature. 550538010747 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010748 cytochrome c-type protein NapC; Provisional; Region: PRK10617 550538010749 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 550538010750 HMMPfam hit to PF03264, NapC/NirT cytochrome c, N-terminal, score 7.1e-124 550538010751 PS00190 Cytochrome c family heme-binding site signature. 550538010752 PS00190 Cytochrome c family heme-binding site signature. 550538010753 PS00190 Cytochrome c family heme-binding site signature. 550538010754 1 probable transmembrane helix predicted for SG2283 by TMHMM2.0 at aa 21-43 550538010755 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 550538010756 HMMPfam hit to PF03892, Nitrate reductase cytochrome c-type subunit (NapB), score 5.7e-51 550538010757 PS00190 Cytochrome c family heme-binding site signature. 550538010758 PS00190 Cytochrome c family heme-binding site signature. 550538010759 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 550538010760 4Fe-4S binding domain; Region: Fer4_5; pfam12801 550538010761 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 550538010762 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00059 550538010763 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010764 4 probable transmembrane helices predicted for SG2285 by TMHMM2.0 at aa 33-55, 75-97, 138-160 and 170-192 550538010765 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 550538010766 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0022 550538010767 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 8.3e-06 550538010768 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010769 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 550538010770 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 550538010771 [4Fe-4S] binding site [ion binding]; other site 550538010772 molybdopterin cofactor binding site; other site 550538010773 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 550538010774 molybdopterin cofactor binding site; other site 550538010775 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 1.3e-32 550538010776 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.5e-138 550538010777 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 2.4e-23 550538010778 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538010779 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 550538010780 HMMPfam hit to PF03927, NapD, score 1.7e-35 550538010781 ferredoxin-type protein; Provisional; Region: PRK10194 550538010782 4Fe-4S binding domain; Region: Fer4; cl02805 550538010783 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.5e-07 550538010784 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010785 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0022 550538010786 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010787 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 550538010788 secondary substrate binding site; other site 550538010789 primary substrate binding site; other site 550538010790 inhibition loop; other site 550538010791 dimerization interface [polypeptide binding]; other site 550538010792 HMMPfam hit to PF03974, Proteinase inhibitor I11, ecotin, score 3.7e-118 550538010793 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 550538010794 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 550538010795 Walker A/P-loop; other site 550538010796 ATP binding site [chemical binding]; other site 550538010797 Q-loop/lid; other site 550538010798 ABC transporter signature motif; other site 550538010799 Walker B; other site 550538010800 D-loop; other site 550538010801 H-loop/switch region; other site 550538010802 HMMPfam hit to PF00005, ABC transporter related, score 6.9e-44 550538010803 PS00211 ABC transporters family signature. 550538010804 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010805 6 probable transmembrane helices predicted for SG2291 by TMHMM2.0 at aa 15-37, 50-72, 120-142, 149-171, 238-260 and 272-294 550538010806 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 550538010807 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase, score 3.6e-08 550538010808 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 550538010809 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 550538010810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538010811 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 550538010812 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 550538010813 DNA binding site [nucleotide binding] 550538010814 active site 550538010815 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 5.7e-57 550538010816 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 550538010817 HMMPfam hit to PF02870, Methylguanine DNA methyltransferase, ribonuclease-like, score 1e-21 550538010818 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.7e-05 550538010819 PS00041 Bacterial regulatory proteins, araC family signature. 550538010820 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.5e-10 550538010821 PS00041 Bacterial regulatory proteins, araC family signature. 550538010822 HMMPfam hit to PF02805, Ada, metal-binding, score 5.7e-44 550538010823 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 550538010824 ApbE family; Region: ApbE; pfam02424 550538010825 HMMPfam hit to PF02424, ApbE-like lipoprotein, score 7.4e-140 550538010826 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010827 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538010828 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 550538010829 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 550538010830 HMMPfam hit to PF00267, Porin, Gram-negative type, score 1.4e-181 550538010831 PS00576 General diffusion Gram-negative porins signature. 550538010832 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538010833 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 550538010834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538010835 ATP binding site [chemical binding]; other site 550538010836 G-X-G motif; other site 550538010837 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 550538010838 putative binding surface; other site 550538010839 active site 550538010840 2 probable transmembrane helices predicted for SG2296 by TMHMM2.0 at aa 20-42 and 308-330 550538010841 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.8e-14 550538010842 HMMPfam hit to PF01627, Hpt, score 2.5e-15 550538010843 transcriptional regulator RcsB; Provisional; Region: PRK10840 550538010844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538010845 active site 550538010846 phosphorylation site [posttranslational modification] 550538010847 intermolecular recognition site; other site 550538010848 dimerization interface [polypeptide binding]; other site 550538010849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538010850 DNA binding residues [nucleotide binding] 550538010851 dimerization interface [polypeptide binding]; other site 550538010852 HMMPfam hit to PF00072, Response regulator receiver, score 1.5e-33 550538010853 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.4e-21 550538010854 PS00622 Bacterial regulatory proteins, luxR family signature. 550538010855 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 550538010856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538010857 dimer interface [polypeptide binding]; other site 550538010858 phosphorylation site [posttranslational modification] 550538010859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538010860 ATP binding site [chemical binding]; other site 550538010861 Mg2+ binding site [ion binding]; other site 550538010862 G-X-G motif; other site 550538010863 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 550538010864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538010865 active site 550538010866 phosphorylation site [posttranslational modification] 550538010867 intermolecular recognition site; other site 550538010868 dimerization interface [polypeptide binding]; other site 550538010869 HMMPfam hit to PF00072, Response regulator receiver, score 1.4e-41 550538010870 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.7e-44 550538010871 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.2e-21 550538010872 DNA gyrase subunit A; Validated; Region: PRK05560 550538010873 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 550538010874 CAP-like domain; other site 550538010875 active site 550538010876 primary dimer interface [polypeptide binding]; other site 550538010877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538010878 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538010879 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538010880 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538010881 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538010882 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538010883 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 9e-14 550538010884 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.5e-15 550538010885 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 1.3e-16 550538010886 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.1e-10 550538010887 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 3.7e-15 550538010888 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.3e-13 550538010889 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 0 550538010890 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 550538010891 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 550538010892 active site pocket [active] 550538010893 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 4.5e-16 550538010894 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 3.7e-27 550538010896 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 9.4e-51 550538010897 Transcriptional regulators [Transcription]; Region: GntR; COG1802 550538010898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538010899 DNA-binding site [nucleotide binding]; DNA binding site 550538010900 FCD domain; Region: FCD; pfam07729 550538010901 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 9.5e-15 550538010902 HMMPfam hit to PF07729, GntR, C-terminal, score 0.00016 550538010903 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 550538010904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538010905 S-adenosylmethionine binding site [chemical binding]; other site 550538010906 HMMPfam hit to PF08241, Methyltransferase type 11, score 2.2e-26 550538010907 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 550538010908 ATP cone domain; Region: ATP-cone; pfam03477 550538010909 Class I ribonucleotide reductase; Region: RNR_I; cd01679 550538010910 active site 550538010911 dimer interface [polypeptide binding]; other site 550538010912 catalytic residues [active] 550538010913 effector binding site; other site 550538010914 R2 peptide binding site; other site 550538010915 HMMPfam hit to PF03477, ATP-cone, score 5.1e-23 550538010916 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 2.1e-23 550538010917 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 7.2e-273 550538010918 PS00089 Ribonucleotide reductase large subunit signature. 550538010919 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 550538010920 dimer interface [polypeptide binding]; other site 550538010921 putative radical transfer pathway; other site 550538010922 diiron center [ion binding]; other site 550538010923 tyrosyl radical; other site 550538010924 PS00368 Ribonucleotide reductase small subunit signature. 550538010925 HMMPfam hit to PF00268, Ribonucleotide reductase, score 6.3e-11 550538010926 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 550538010927 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 550538010928 catalytic loop [active] 550538010929 iron binding site [ion binding]; other site 550538010930 HMMPfam hit to PF00111, Ferredoxin, score 5.7e-15 550538010931 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 550538010932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538010933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010934 putative substrate translocation pore; other site 550538010935 12 probable transmembrane helices predicted for SG2308 by TMHMM2.0 at aa 13-35, 45-64, 76-95, 100-122, 135-154, 164-186, 208-230, 240-262, 269-291, 295-317, 330-352 and 357-379 550538010936 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.9e-51 550538010937 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 550538010938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538010939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538010940 dimerization interface [polypeptide binding]; other site 550538010941 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.3e-15 550538010942 PS00044 Bacterial regulatory proteins, lysR family signature. 550538010943 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.9e-34 550538010944 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 550538010945 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 550538010946 active site 550538010947 catalytic site [active] 550538010948 metal binding site [ion binding]; metal-binding site 550538010949 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 8e-110 550538010950 PS00017 ATP/GTP-binding site motif A (P-loop). 550538010951 1 probable transmembrane helix predicted for SG2310 by TMHMM2.0 at aa 7-26 550538010952 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 550538010953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010954 putative substrate translocation pore; other site 550538010955 12 probable transmembrane helices predicted for SG2311 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 161-183, 188-207, 254-273, 293-312, 319-341, 351-373, 386-408 and 418-437 550538010956 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.6e-48 550538010957 PS00942 glpT family of transporters signature. 550538010958 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 550538010959 hydroxyglutarate oxidase; Provisional; Region: PRK11728 550538010960 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 550538010961 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.2e-71 550538010962 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 550538010963 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 550538010964 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 3.2e-18 550538010965 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 550538010966 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 550538010967 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 2.3e-88 550538010968 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 550538010969 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 550538010970 Cysteine-rich domain; Region: CCG; pfam02754 550538010971 Cysteine-rich domain; Region: CCG; pfam02754 550538010972 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010973 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0022 550538010974 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538010975 HMMPfam hit to PF02754, Cysteine-rich region, CCG, score 9.9e-09 550538010976 HMMPfam hit to PF02754, Cysteine-rich region, CCG, score 1.1e-14 550538010977 deubiquitinase SseL; Provisional; Region: PRK14848 550538010978 hypothetical protein; Provisional; Region: PRK03673 550538010979 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 550538010980 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 2.4e-108 550538010981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538010982 D-galactonate transporter; Region: 2A0114; TIGR00893 550538010983 putative substrate translocation pore; other site 550538010984 12 probable transmembrane helices predicted for SG2318 by TMHMM2.0 at aa 13-30, 52-74, 79-101, 107-129, 142-164, 174-196, 241-263, 273-295, 308-325, 329-351, 358-380 and 395-417 550538010985 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.3e-48 550538010986 PS00107 Protein kinases ATP-binding region signature. 550538010987 L-rhamnonate dehydratase; Provisional; Region: PRK15440 550538010988 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 550538010989 putative active site pocket [active] 550538010990 putative metal binding site [ion binding]; other site 550538010991 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.7e-27 550538010992 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 0.00026 550538010993 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 550538010994 Transcriptional regulator [Transcription]; Region: IclR; COG1414 550538010995 Bacterial transcriptional regulator; Region: IclR; pfam01614 550538010996 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 1.9e-53 550538010997 PS01051 Bacterial regulatory proteins, iclR family signature. 550538010998 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 3e-13 550538010999 hypothetical protein; Provisional; Region: PRK03673 550538011000 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 550538011001 putative MPT binding site; other site 550538011002 Competence-damaged protein; Region: CinA; cl00666 550538011003 HMMPfam hit to PF00994, Molybdopterin binding, score 4.2e-47 550538011005 HMMPfam hit to PF07437, YfaZ, score 4.3e-114 550538011006 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 550538011007 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 4.3e-28 550538011008 PS00893 mutT domain signature. 550538011009 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 550538011010 catalytic core [active] 550538011011 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 6.6e-10 550538011012 1 probable transmembrane helix predicted for SG2325 by TMHMM2.0 at aa 13-35 550538011013 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 550538011014 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 550538011015 inhibitor-cofactor binding pocket; inhibition site 550538011016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538011017 catalytic residue [active] 550538011018 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 7.8e-179 550538011019 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 550538011020 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 550538011021 Ligand binding site; other site 550538011022 Putative Catalytic site; other site 550538011023 DXD motif; other site 550538011024 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 9.1e-36 550538011025 2 probable transmembrane helices predicted for SG2327 by TMHMM2.0 at aa 235-257 and 272-294 550538011026 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 550538011027 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 550538011028 active site 550538011029 substrate binding site [chemical binding]; other site 550538011030 cosubstrate binding site; other site 550538011031 catalytic site [active] 550538011032 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 550538011033 active site 550538011034 hexamer interface [polypeptide binding]; other site 550538011035 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 550538011036 NAD binding site [chemical binding]; other site 550538011037 substrate binding site [chemical binding]; other site 550538011038 active site 550538011039 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 3.2e-11 550538011040 HMMPfam hit to PF02911, Formyl transferase, C-terminal, score 3.2e-33 550538011041 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 8.5e-49 550538011042 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 550538011043 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 550538011044 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 0.00027 550538011045 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 550538011046 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 550538011047 HMMPfam hit to PF02366, Glycosyl transferase, family 39, score 5.5e-72 550538011048 12 probable transmembrane helices predicted for SG2330 by TMHMM2.0 at aa 7-29, 82-104, 113-135, 139-156, 163-185, 205-227, 258-280, 290-307, 314-331, 346-368, 381-400 and 405-424 550538011049 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 550538011050 3 probable transmembrane helices predicted for SG2331 by TMHMM2.0 at aa 36-58, 63-85 and 92-110 550538011051 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.5e-08 550538011052 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 550538011053 4 probable transmembrane helices predicted for SG2332 by TMHMM2.0 at aa 5-27, 42-64, 71-90 and 100-122 550538011054 signal transduction protein PmrD; Provisional; Region: PRK15450 550538011055 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 550538011056 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 550538011057 acyl-activating enzyme (AAE) consensus motif; other site 550538011058 putative AMP binding site [chemical binding]; other site 550538011059 putative active site [active] 550538011060 putative CoA binding site [chemical binding]; other site 550538011061 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 6.8e-62 550538011062 PS00455 AMP-binding domain signature. 550538011063 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 550538011064 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 550538011065 active site 550538011066 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.1e-11 550538011067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 550538011068 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 550538011069 substrate binding site [chemical binding]; other site 550538011070 oxyanion hole (OAH) forming residues; other site 550538011071 trimer interface [polypeptide binding]; other site 550538011072 HMMPfam hit to PF00378, Crotonase, core, score 4.3e-72 550538011073 PS00166 Enoyl-CoA hydratase/isomerase signature. 550538011074 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 550538011075 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 5e-09 550538011076 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 550538011077 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 550538011078 dimer interface [polypeptide binding]; other site 550538011079 tetramer interface [polypeptide binding]; other site 550538011080 PYR/PP interface [polypeptide binding]; other site 550538011081 TPP binding site [chemical binding]; other site 550538011082 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 550538011083 TPP-binding site; other site 550538011084 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 0.0018 550538011085 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 550538011086 isochorismate synthases; Region: isochor_syn; TIGR00543 550538011087 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 2.3e-19 550538011088 hypothetical protein; Provisional; Region: PRK10404 550538011089 HMMPfam hit to PF05957, Protein of unknown function DUF883, ElaB, score 3.4e-49 550538011090 1 probable transmembrane helix predicted for SG2340 by TMHMM2.0 at aa 82-101 550538011091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538011092 Coenzyme A binding pocket [chemical binding]; other site 550538011093 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.4e-10 550538011094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 550538011095 HMMPfam hit to PF00753, Beta-lactamase-like, score 4e-10 550538011096 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011097 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 550538011098 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 550538011099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538011100 active site 550538011101 phosphorylation site [posttranslational modification] 550538011102 intermolecular recognition site; other site 550538011103 dimerization interface [polypeptide binding]; other site 550538011104 HMMPfam hit to PF01584, CheW-like protein, score 6.4e-28 550538011105 HMMPfam hit to PF00072, Response regulator receiver, score 1.8e-07 550538011106 von Willebrand factor; Region: vWF_A; pfam12450 550538011107 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 550538011108 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 550538011109 metal ion-dependent adhesion site (MIDAS); other site 550538011110 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 550538011111 PS00107 Protein kinases ATP-binding region signature. 550538011112 HMMPfam hit to PF00092, von Willebrand factor, type A, score 3.5e-24 550538011113 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 550538011114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 550538011115 14 probable transmembrane helices predicted for SG2345 by TMHMM2.0 at aa 6-28, 35-57, 72-94, 106-120, 125-147, 159-181, 201-223, 236-258, 268-290, 297-319, 329-351, 371-393, 408-430 and 450-472 550538011116 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 1.2e-96 550538011117 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 550538011118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 550538011119 14 probable transmembrane helices predicted for SG2346 by TMHMM2.0 at aa 4-18, 30-49, 81-103, 115-134, 139-161, 174-196, 222-244, 251-273, 288-307, 314-336, 341-363, 384-406, 416-438 and 459-481 550538011120 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 2.4e-75 550538011121 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 550538011122 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 550538011123 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 550538011124 16 probable transmembrane helices predicted for SG2347 by TMHMM2.0 at aa 4-21, 28-50, 84-106, 113-132, 136-158, 171-193, 213-235, 248-267, 277-299, 306-328, 332-354, 375-397, 412-434, 455-477, 492-514 and 590-612 550538011125 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 1.2e-122 550538011126 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex I), chain 5/L, N-terminal, score 1.5e-29 550538011127 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 550538011128 HMMPfam hit to PF00420, NADH-ubiquinone oxidoreductase, chain 4L, score 7.1e-32 550538011129 3 probable transmembrane helices predicted for SG2348 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 550538011130 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 550538011131 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 550538011132 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreductase, chain 6, score 9e-32 550538011133 5 probable transmembrane helices predicted for SG2349 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 550538011134 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 550538011135 4Fe-4S binding domain; Region: Fer4; pfam00037 550538011136 4Fe-4S binding domain; Region: Fer4; pfam00037 550538011137 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.8e-08 550538011138 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538011139 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00012 550538011140 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538011141 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 550538011142 9 probable transmembrane helices predicted for SG2351 by TMHMM2.0 at aa 13-35, 50-69, 81-103, 113-135, 155-174, 184-206, 235-257, 267-289 and 302-324 550538011143 HMMPfam hit to PF00146, Respiratory-chain NADH dehydrogenase, subunit 1, score 1.1e-184 550538011144 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 550538011145 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 550538011146 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 550538011147 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 550538011148 catalytic loop [active] 550538011149 iron binding site [ion binding]; other site 550538011150 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 550538011151 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 550538011152 [4Fe-4S] binding site [ion binding]; other site 550538011153 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 550538011154 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 9.8e-06 550538011155 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.4e-06 550538011156 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 4.4e-15 550538011157 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 550538011158 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 550538011159 HMMPfam hit to PF00111, Ferredoxin, score 4.8e-14 550538011160 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 550538011161 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 550538011162 SLBB domain; Region: SLBB; pfam10531 550538011163 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 550538011164 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 550538011165 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit, score 5.1e-181 550538011166 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 550538011167 NADH dehydrogenase subunit E; Validated; Region: PRK07539 550538011168 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 550538011169 putative dimer interface [polypeptide binding]; other site 550538011170 [2Fe-2S] cluster binding site [ion binding]; other site 550538011171 HMMPfam hit to PF01257, NADH dehydrogenase (ubiquinone), 24 kDa subunit, score 1e-103 550538011172 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 550538011173 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 550538011174 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 550538011175 NADH dehydrogenase subunit D; Validated; Region: PRK06075 550538011176 HMMPfam hit to PF00346, NADH-ubiquinone oxidoreductase, chain 49kDa, score 1.5e-216 550538011177 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 550538011178 HMMPfam hit to PF00329, NADH dehydrogenase (ubiquinone), 30 kDa subunit, score 4.2e-40 550538011179 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 550538011180 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 1.5e-56 550538011181 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 550538011182 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 550538011183 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3, score 5.1e-37 550538011184 3 probable transmembrane helices predicted for SG2357 by TMHMM2.0 at aa 15-37, 68-90 and 100-122 550538011185 PS00012 Phosphopantetheine attachment site. 550538011186 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 550538011187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538011188 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 550538011189 putative dimerization interface [polypeptide binding]; other site 550538011190 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.9e-30 550538011191 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 550538011192 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.8e-16 550538011193 PS00044 Bacterial regulatory proteins, lysR family signature. 550538011194 aminotransferase AlaT; Validated; Region: PRK09265 550538011195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538011196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538011197 homodimer interface [polypeptide binding]; other site 550538011198 catalytic residue [active] 550538011199 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 5.7e-37 550538011200 5'-nucleotidase; Provisional; Region: PRK03826 550538011201 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 1.2e-15 550538011202 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 550538011203 transmembrane helices; other site 550538011204 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 550538011205 TrkA-C domain; Region: TrkA_C; pfam02080 550538011206 TrkA-C domain; Region: TrkA_C; pfam02080 550538011207 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 550538011208 11 probable transmembrane helices predicted for SG2362 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 96-118, 138-160, 173-195, 427-449, 462-480, 500-522, 542-564 and 584-606 550538011209 PS01271 Sodium:sulfate symporter family signature. 550538011210 HMMPfam hit to PF03600, Divalent ion symporter, score 2.2e-51 550538011211 HMMPfam hit to PF02080, TrkA-C, score 6.6e-11 550538011212 HMMPfam hit to PF02080, TrkA-C, score 7.8e-12 550538011213 putative phosphatase; Provisional; Region: PRK11587 550538011214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538011215 motif II; other site 550538011216 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 4.1e-40 550538011217 hypothetical protein; Validated; Region: PRK05445 550538011218 HMMPfam hit to PF03887, YfbU, score 1.1e-118 550538011219 hypothetical protein; Provisional; Region: PRK01816 550538011220 HMMPfam hit to PF04217, Protein of unknown function DUF412, score 1.6e-108 550538011221 2 probable transmembrane helices predicted for SG2365 by TMHMM2.0 at aa 46-65 and 69-91 550538011222 propionate/acetate kinase; Provisional; Region: PRK12379 550538011223 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 550538011224 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 2.9e-258 550538011225 PS01075 Acetate and butyrate kinases family signature 1. 550538011226 PS01076 Acetate and butyrate kinases family signature 2. 550538011227 phosphate acetyltransferase; Reviewed; Region: PRK05632 550538011228 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 550538011229 DRTGG domain; Region: DRTGG; pfam07085 550538011230 phosphate acetyltransferase; Region: pta; TIGR00651 550538011231 HMMPfam hit to PF07085, DRTGG, score 9.4e-58 550538011232 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 3.7e-191 550538011233 hypothetical protein; Provisional; Region: PRK11588 550538011234 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 550538011235 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.7e-233 550538011236 11 probable transmembrane helices predicted for SG2368 by TMHMM2.0 at aa 19-41, 106-127, 148-165, 175-197, 204-226, 230-252, 287-309, 314-336, 349-371, 398-415 and 481-503 550538011237 PS00012 Phosphopantetheine attachment site. 550538011238 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 550538011239 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 550538011240 PYR/PP interface [polypeptide binding]; other site 550538011241 dimer interface [polypeptide binding]; other site 550538011242 TPP binding site [chemical binding]; other site 550538011243 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 550538011244 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.2e-39 550538011245 HMMPfam hit to PF02779, Transketolase, central region, score 2.6e-15 550538011246 transketolase; Reviewed; Region: PRK05899 550538011247 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 550538011248 TPP-binding site [chemical binding]; other site 550538011249 dimer interface [polypeptide binding]; other site 550538011250 HMMPfam hit to PF00456, Transketolase, N-terminal, score 2.5e-40 550538011251 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 550538011252 11 probable transmembrane helices predicted for SG2371 by TMHMM2.0 at aa 10-32, 39-61, 95-114, 121-143, 147-169, 226-243, 258-280, 310-332, 342-364, 377-399 and 409-440 550538011253 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 8.8e-128 550538011254 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 550538011255 active site 550538011256 P-loop; other site 550538011257 phosphorylation site [posttranslational modification] 550538011258 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.9e-20 550538011259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538011260 active site 550538011261 phosphorylation site [posttranslational modification] 550538011262 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 6.9e-36 550538011263 Transcriptional regulators [Transcription]; Region: PurR; COG1609 550538011264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538011265 DNA binding site [nucleotide binding] 550538011266 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 550538011267 putative dimerization interface [polypeptide binding]; other site 550538011268 putative ligand binding site [chemical binding]; other site 550538011269 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 5.7e-10 550538011270 PS00356 Bacterial regulatory proteins, lacI family signature. 550538011271 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 9.9e-08 550538011272 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 550538011273 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 550538011274 nudix motif; other site 550538011275 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 2.1e-27 550538011276 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 550538011277 active site 550538011278 metal binding site [ion binding]; metal-binding site 550538011279 homotetramer interface [polypeptide binding]; other site 550538011280 PS01269 Uncharacterized protein family UPF0025 signature. 550538011281 HMMPfam hit to PF00149, Metallophosphoesterase, score 5.1e-16 550538011282 glutathione S-transferase; Provisional; Region: PRK15113 550538011283 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 550538011284 C-terminal domain interface [polypeptide binding]; other site 550538011285 GSH binding site (G-site) [chemical binding]; other site 550538011286 dimer interface [polypeptide binding]; other site 550538011287 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 550538011288 N-terminal domain interface [polypeptide binding]; other site 550538011289 putative dimer interface [polypeptide binding]; other site 550538011290 putative substrate binding pocket (H-site) [chemical binding]; other site 550538011291 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 1.5e-11 550538011292 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 550538011293 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 550538011294 C-terminal domain interface [polypeptide binding]; other site 550538011295 GSH binding site (G-site) [chemical binding]; other site 550538011296 dimer interface [polypeptide binding]; other site 550538011297 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 550538011298 N-terminal domain interface [polypeptide binding]; other site 550538011299 putative dimer interface [polypeptide binding]; other site 550538011300 active site 550538011301 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 1.3e-07 550538011302 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 1.7e-10 550538011303 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 550538011304 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 550538011305 putative NAD(P) binding site [chemical binding]; other site 550538011306 putative active site [active] 550538011307 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 3.5e-22 550538011308 HMMPfam hit to PF08338, Region of unknown function DUF1731, score 3.1e-23 550538011309 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 550538011310 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 550538011311 Walker A/P-loop; other site 550538011312 ATP binding site [chemical binding]; other site 550538011313 Q-loop/lid; other site 550538011314 ABC transporter signature motif; other site 550538011315 Walker B; other site 550538011316 D-loop; other site 550538011317 H-loop/switch region; other site 550538011318 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-63 550538011319 PS00211 ABC transporters family signature. 550538011320 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011321 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538011322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538011323 dimer interface [polypeptide binding]; other site 550538011324 conserved gate region; other site 550538011325 putative PBP binding loops; other site 550538011326 ABC-ATPase subunit interface; other site 550538011327 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.2e-14 550538011328 4 probable transmembrane helices predicted for SG2381 by TMHMM2.0 at aa 25-47, 57-79, 149-171 and 199-221 550538011329 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 550538011330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538011331 dimer interface [polypeptide binding]; other site 550538011332 conserved gate region; other site 550538011333 putative PBP binding loops; other site 550538011334 ABC-ATPase subunit interface; other site 550538011335 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.8e-39 550538011336 5 probable transmembrane helices predicted for SG2382 by TMHMM2.0 at aa 15-37, 58-80, 90-108, 149-171 and 191-213 550538011337 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011338 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538011339 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 550538011340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538011341 substrate binding pocket [chemical binding]; other site 550538011342 membrane-bound complex binding site; other site 550538011343 hinge residues; other site 550538011344 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 3.2e-97 550538011345 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 550538011346 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 550538011347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538011348 substrate binding pocket [chemical binding]; other site 550538011349 membrane-bound complex binding site; other site 550538011350 hinge residues; other site 550538011351 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 9.1e-90 550538011352 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 550538011353 1 probable transmembrane helix predicted for SG2384 by TMHMM2.0 at aa 5-24 550538011354 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 550538011355 Flavoprotein; Region: Flavoprotein; pfam02441 550538011356 HMMPfam hit to PF02441, Flavoprotein, score 8.7e-51 550538011357 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 550538011358 12 probable transmembrane helices predicted for SG2386 by TMHMM2.0 at aa 25-47, 57-79, 86-108, 128-150, 163-185, 200-222, 243-265, 292-314, 334-356, 366-388, 409-431 and 435-457 550538011359 HMMPfam hit to PF00324, Amino acid permease-associated region, score 5.6e-100 550538011360 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011361 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 550538011362 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 550538011363 dimer interface [polypeptide binding]; other site 550538011364 active site 550538011365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538011366 substrate binding site [chemical binding]; other site 550538011367 catalytic residue [active] 550538011368 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 9.1e-15 550538011369 the sequence has been checked and is believed to be correct 550538011370 HMMPfam hit to PF00324, Amino acid permease-associated region, score 4.5e-05 550538011371 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 550538011372 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 550538011373 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538011374 catalytic residue [active] 550538011375 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 1.6e-25 550538011376 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 3.2e-34 550538011378 HMMPfam hit to PF08448, PAS fold-4, score 4.4e-07 550538011379 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 4.5e-119 550538011380 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.6e-14 550538011381 amidophosphoribosyltransferase; Provisional; Region: PRK09246 550538011382 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 550538011383 active site 550538011384 tetramer interface [polypeptide binding]; other site 550538011385 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538011386 active site 550538011387 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 9.5e-13 550538011388 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538011389 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1e-67 550538011390 PS00443 Glutamine amidotransferases class-II active site. 550538011391 colicin V production protein; Provisional; Region: PRK10845 550538011392 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 550538011393 HMMPfam hit to PF02674, Colicin V production protein, score 4e-60 550538011394 4 probable transmembrane helices predicted for SG2393 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 550538011395 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538011396 cell division protein DedD; Provisional; Region: PRK11633 550538011397 Sporulation related domain; Region: SPOR; pfam05036 550538011398 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 6.7e-16 550538011399 1 probable transmembrane helix predicted for SG2394 by TMHMM2.0 at aa 10-27 550538011400 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 550538011401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 550538011402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 550538011403 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 0.0033 550538011404 HMMPfam hit to PF08245, Mur ligase, central, score 2.1e-06 550538011405 PS01012 Folylpolyglutamate synthase signature 2. 550538011406 PS01011 Folylpolyglutamate synthase signature 1. 550538011407 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 550538011408 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 550538011409 HMMPfam hit to PF01039, Carboxyl transferase, score 9.6e-13 550538011410 hypothetical protein; Provisional; Region: PRK10847 550538011411 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 550538011412 4 probable transmembrane helices predicted for SG2397 by TMHMM2.0 at aa 27-49, 71-93, 158-180 and 190-208 550538011413 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 2.3e-06 550538011414 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 550538011415 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 550538011416 dimerization interface 3.5A [polypeptide binding]; other site 550538011417 active site 550538011418 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 5.2e-31 550538011419 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3.5e-37 550538011420 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 550538011421 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 550538011422 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 1.6e-55 550538011423 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 8.3e-39 550538011424 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 550538011425 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 550538011426 ligand binding site [chemical binding]; other site 550538011427 NAD binding site [chemical binding]; other site 550538011428 catalytic site [active] 550538011429 homodimer interface [polypeptide binding]; other site 550538011430 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 1.2e-26 550538011431 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 3.6e-29 550538011432 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 550538011433 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 550538011434 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 550538011435 1 probable transmembrane helix predicted for SG2401 by TMHMM2.0 at aa 310-332 550538011436 putative transporter; Provisional; Region: PRK12382 550538011437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538011438 putative substrate translocation pore; other site 550538011439 12 probable transmembrane helices predicted for SG2402 by TMHMM2.0 at aa 20-42, 52-71, 83-105, 120-142, 149-171, 176-198, 210-232, 247-269, 276-298, 303-325, 338-360 and 370-389 550538011440 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5.4e-34 550538011441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538011442 non-specific DNA binding site [nucleotide binding]; other site 550538011443 salt bridge; other site 550538011444 sequence-specific DNA binding site [nucleotide binding]; other site 550538011445 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 3.8e-06 550538011446 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 550538011447 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538011448 CAAX protease self-immunity; Region: Abi; pfam02517 550538011449 7 probable transmembrane helices predicted for SG2407 by TMHMM2.0 at aa 12-31, 41-63, 75-97, 117-139, 146-163, 168-187 and 194-216 550538011450 HMMPfam hit to PF02517, Abortive infection protein, score 4.4e-14 550538011451 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 550538011452 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 550538011453 dimer interface [polypeptide binding]; other site 550538011454 active site 550538011455 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal, score 2.7e-43 550538011456 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal, score 6.6e-58 550538011457 PS00606 Beta-ketoacyl synthases active site. 550538011458 Uncharacterized conserved protein [Function unknown]; Region: COG4121 550538011459 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 550538011460 HMMPfam hit to PF05430, Protein of unknown function DUF752, score 1.3e-147 550538011461 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.9e-60 550538011462 PS00659 Glycosyl hydrolases family 5 signature. 550538011463 YfcL protein; Region: YfcL; pfam08891 550538011464 HMMPfam hit to PF08891, YfcL protein, score 7.1e-49 550538011465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 550538011466 HMMPfam hit to PF04315, Protein of unknown function DUF462, score 1.2e-147 550538011467 hypothetical protein; Provisional; Region: PRK10621 550538011468 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 550538011469 8 probable transmembrane helices predicted for SG2412 by TMHMM2.0 at aa 7-28, 32-54, 85-104, 108-127, 139-158, 163-182, 195-217 and 237-255 550538011470 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 3.6e-62 550538011471 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 550538011472 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 550538011473 HMMPfam hit to PF03411, Peptidase M74, penicillin-insensitive murein endopeptidase, score 4.1e-195 550538011474 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 550538011475 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 550538011476 Tetramer interface [polypeptide binding]; other site 550538011477 active site 550538011478 FMN-binding site [chemical binding]; other site 550538011479 HMMPfam hit to PF01264, Chorismate synthase, score 3.3e-236 550538011480 PS00789 Chorismate synthase signature 3. 550538011481 PS00788 Chorismate synthase signature 2. 550538011482 PS00787 Chorismate synthase signature 1. 550538011483 HemK family putative methylases; Region: hemK_fam; TIGR00536 550538011484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538011485 S-adenosylmethionine binding site [chemical binding]; other site 550538011486 PS00092 N-6 Adenine-specific DNA methylases signature. 550538011487 HMMPfam hit to PF08242, Methyltransferase type 12, score 3.6e-07 550538011488 hypothetical protein; Provisional; Region: PRK04946 550538011489 Smr domain; Region: Smr; pfam01713 550538011490 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 8.7e-33 550538011491 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 550538011492 catalytic core [active] 550538011493 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 2.1e-12 550538011494 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 550538011495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 550538011496 substrate binding site [chemical binding]; other site 550538011497 oxyanion hole (OAH) forming residues; other site 550538011498 trimer interface [polypeptide binding]; other site 550538011499 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 550538011500 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 550538011501 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 2.3e-40 550538011502 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 550538011503 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 2.5e-83 550538011504 HMMPfam hit to PF00378, Crotonase, core, score 1.1e-64 550538011505 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 550538011506 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 550538011507 dimer interface [polypeptide binding]; other site 550538011508 active site 550538011509 HMMPfam hit to PF02803, Thiolase, score 1.8e-57 550538011510 PS00099 Thiolases active site. 550538011511 PS00737 Thiolases signature 2. 550538011512 HMMPfam hit to PF00108, Thiolase, score 1e-53 550538011513 PS00098 Thiolases acyl-enzyme intermediate signature. 550538011514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 550538011515 HMMPfam hit to PF04175, Conserved hypothetical protein CHP00743, score 1.4e-60 550538011516 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 550538011517 HMMPfam hit to PF03349, Membrane protein involved in aromatic hydrocarbon degradation, score 2.3e-191 550538011518 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 550538011519 HMMPfam hit to PF04333, VacJ-like lipoprotein, score 1.2e-119 550538011520 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538011521 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 550538011522 6 probable transmembrane helices predicted for SG2424 by TMHMM2.0 at aa 62-84, 94-116, 137-159, 190-209, 216-235 and 255-277 550538011523 prophage remnant carrying O-chain modification proteins; Salmonella pathogenicity island 17: SPI-17 550538011524 the sequence has been checked and is believed to be correct 550538011525 HMMPfam hit to PF00872, Transposase, mutator type, score 3e-23 550538011526 Predicted membrane protein [Function unknown]; Region: COG2246 550538011527 GtrA-like protein; Region: GtrA; pfam04138 550538011528 HMMPfam hit to PF04138, GtrA-like protein, score 9.5e-24 550538011529 3 probable transmembrane helices predicted for SG2427 by TMHMM2.0 at aa 30-52, 65-84 and 94-116 550538011530 Notes appears to have been subject to a deletion event removing the majority of the 3' region of the CDS 550538011531 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 6.2e-11 550538011532 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 550538011533 HMMPfam hit to PF01757, Acyltransferase 3, score 1.1e-67 550538011534 11 probable transmembrane helices predicted for SG2429 by TMHMM2.0 at aa 13-35, 40-59, 72-94, 134-156, 168-186, 201-218, 225-242, 246-268, 275-297, 312-333 and 345-367 550538011537 HMMPfam hit to PF09251, Bacteriophage P22, tailspike, score 7.3e-24 550538011538 HMMPfam hit to PF09251, Bacteriophage P22, tailspike, score 2.2e-25 550538011539 outer membrane protease; Reviewed; Region: PRK10993 550538011540 HMMPfam hit to PF01278, Peptidase A26, omptin, score 5e-217 550538011541 PS00835 Serine proteases, omptin family signature 2. 550538011542 PS00834 Serine proteases, omptin family signature 1. 550538011543 PS00018 EF-hand calcium-binding domain. 550538011544 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 550538011545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538011546 active site 550538011547 phosphorylation site [posttranslational modification] 550538011548 intermolecular recognition site; other site 550538011549 dimerization interface [polypeptide binding]; other site 550538011550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 550538011551 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 550538011552 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 7.5e-15 550538011553 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538011554 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 5.2e-12 550538011555 HMMPfam hit to PF00072, Response regulator receiver, score 2.5e-40 550538011556 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 550538011557 HAMP domain; Region: HAMP; pfam00672 550538011558 dimerization interface [polypeptide binding]; other site 550538011559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538011560 dimer interface [polypeptide binding]; other site 550538011561 phosphorylation site [posttranslational modification] 550538011562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538011563 ATP binding site [chemical binding]; other site 550538011564 Mg2+ binding site [ion binding]; other site 550538011565 G-X-G motif; other site 550538011566 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.5e-25 550538011567 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 6.4e-08 550538011568 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 6.2e-11 550538011569 2 probable transmembrane helices predicted for SG2433 by TMHMM2.0 at aa 20-39 and 335-357 550538011570 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 550538011571 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 550538011572 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 5.5e-06 550538011573 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 550538011574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538011575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538011576 12 probable transmembrane helices predicted for SG2435 by TMHMM2.0 at aa 21-43, 63-85, 98-120, 124-146, 158-180, 190-207, 260-282, 297-315, 327-344, 348-370, 377-399 and 414-436 550538011577 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.2e-46 550538011578 PS00942 glpT family of transporters signature. 550538011579 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 550538011580 3 probable transmembrane helices predicted for SG2436 by TMHMM2.0 at aa 2-24, 29-48 and 55-77 550538011581 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 550538011582 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 550538011583 putative acyl-acceptor binding pocket; other site 550538011584 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltransferase, score 3.1e-147 550538011585 1 probable transmembrane helix predicted for SG2437 by TMHMM2.0 at aa 20-42 550538011586 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538011587 aminotransferase; Validated; Region: PRK08175 550538011588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538011589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538011590 homodimer interface [polypeptide binding]; other site 550538011591 catalytic residue [active] 550538011592 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.9e-63 550538011593 glucokinase; Provisional; Region: glk; PRK00292 550538011594 glucokinase, proteobacterial type; Region: glk; TIGR00749 550538011595 HMMPfam hit to PF02685, Glucokinase, score 1.8e-189 550538011596 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 550538011597 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 550538011598 Cl- selectivity filter; other site 550538011599 Cl- binding residues [ion binding]; other site 550538011600 pore gating glutamate residue; other site 550538011601 dimer interface [polypeptide binding]; other site 550538011602 11 probable transmembrane helices predicted for SG2440 by TMHMM2.0 at aa 15-37, 57-79, 99-118, 123-140, 150-172, 188-210, 225-247, 260-282, 300-322, 343-365 and 385-407 550538011603 HMMPfam hit to PF00654, Chloride channel, core, score 3.8e-05 550538011604 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 550538011605 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 550538011606 dimer interface [polypeptide binding]; other site 550538011607 PYR/PP interface [polypeptide binding]; other site 550538011608 TPP binding site [chemical binding]; other site 550538011609 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 550538011610 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 550538011611 TPP-binding site [chemical binding]; other site 550538011612 dimer interface [polypeptide binding]; other site 550538011613 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 5.3e-18 550538011614 PS00187 Thiamine pyrophosphate enzymes signature. 550538011615 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 9.4e-16 550538011616 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 3.4e-76 550538011617 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 550538011618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538011619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538011620 active site 550538011621 catalytic tetrad [active] 550538011622 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.5e-62 550538011623 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 550538011624 1 probable transmembrane helix predicted for SG2443 by TMHMM2.0 at aa 5-27 550538011625 manganese transport protein MntH; Reviewed; Region: PRK00701 550538011626 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 550538011627 11 probable transmembrane helices predicted for SG2444 by TMHMM2.0 at aa 17-39, 54-76, 96-118, 123-145, 157-176, 196-218, 239-261, 281-303, 324-343, 348-370 and 390-412 550538011628 HMMPfam hit to PF01566, Natural resistance-associated macrophage protein, score 4.9e-197 550538011629 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 550538011630 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 550538011631 Nucleoside recognition; Region: Gate; pfam07670 550538011632 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 550538011633 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter, score 2.7e-33 550538011634 8 probable transmembrane helices predicted for SG2445 by TMHMM2.0 at aa 4-23, 30-48, 86-108, 194-216, 249-271, 278-300, 342-364 and 377-399 550538011635 HMMPfam hit to PF07670, Nucleoside recognition, score 1.8e-18 550538011636 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter, C-terminal, score 4e-106 550538011637 note the pfam EAL GGDE and MASE1 domains 550538011638 HMMPfam hit to PF00563, EAL, score 9.7e-94 550538011639 HMMPfam hit to PF00990, GGDEF domain 550538011640 HMMPfam hit to PF00990, GGDEF, score 0.00016 550538011641 HMMPfam hit to PF05231, MASE1, score 4e-73 550538011642 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 550538011643 HMMPfam hit to PF07037, Protein of unknown function DUF1323, score 7.7e-81 550538011644 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 550538011645 HMMPfam hit to PF07037, Protein of unknown function DUF1323, score 5.8e-91 550538011646 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 550538011647 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 550538011648 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 550538011649 active site 550538011650 KMSKS motif; other site 550538011651 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 7.1e-135 550538011652 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 550538011653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538011654 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 550538011655 putative dimerization interface [polypeptide binding]; other site 550538011656 putative substrate binding pocket [chemical binding]; other site 550538011657 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.2e-39 550538011658 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.6e-20 550538011659 PS00044 Bacterial regulatory proteins, lysR family signature. 550538011660 nucleoside transporter; Region: 2A0110; TIGR00889 550538011661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538011662 putative substrate translocation pore; other site 550538011663 HMMPfam hit to PF03825, Nucleoside:H+ symporter, score 3.5e-285 550538011664 12 probable transmembrane helices predicted for SG2453 by TMHMM2.0 at aa 12-30, 40-62, 71-90, 94-116, 128-150, 160-179, 211-233, 253-275, 282-301, 306-328, 348-370 and 380-402 550538011665 purine nucleoside phosphorylase; Provisional; Region: PRK08202 550538011666 HMMPfam hit to PF00896, Purine phosphorylase, family 2, score 3e-126 550538011667 hypothetical protein; Provisional; Region: PRK11528 550538011668 HMMPfam hit to PF07135, Protein of unknown function DUF1384, score 2.5e-179 550538011669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538011670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538011671 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 550538011672 putative dimerization interface [polypeptide binding]; other site 550538011673 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.4e-48 550538011674 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.5e-23 550538011675 PS00044 Bacterial regulatory proteins, lysR family signature. 550538011676 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 550538011677 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 550538011678 9 probable transmembrane helices predicted for SG2457 by TMHMM2.0 at aa 7-24, 29-48, 69-91, 101-123, 130-152, 167-189, 202-224, 229-251 and 272-294 550538011679 HMMPfam hit to PF01758, Bile acid:sodium symporter, score 0.0008 550538011680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 550538011681 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 550538011682 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 550538011683 nucleotide binding pocket [chemical binding]; other site 550538011684 K-X-D-G motif; other site 550538011685 catalytic site [active] 550538011686 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 550538011687 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 550538011688 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 550538011689 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 550538011690 Dimer interface [polypeptide binding]; other site 550538011691 BRCT sequence motif; other site 550538011692 HMMPfam hit to PF00533, BRCT, score 1.7e-19 550538011693 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.6e-06 550538011694 HMMPfam hit to PF03119, Zinc-finger, NAD-dependent DNA ligase C4-type, score 5.2e-13 550538011695 HMMPfam hit to PF03120, NAD-dependent DNA ligase, OB-fold, score 2.8e-53 550538011696 PS01056 NAD-dependent DNA ligase signature 2. 550538011697 HMMPfam hit to PF01653, NAD-dependent DNA ligase, adenylation, score 8.5e-212 550538011698 PS01055 NAD-dependent DNA ligase signature 1. 550538011699 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 550538011700 cell division protein ZipA; Provisional; Region: PRK03427 550538011701 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 550538011702 FtsZ protein binding site [polypeptide binding]; other site 550538011703 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding region, score 4.7e-90 550538011704 1 probable transmembrane helix predicted for SG2460 by TMHMM2.0 at aa 5-27 550538011705 putative sulfate transport protein CysZ; Validated; Region: PRK04949 550538011706 4 probable transmembrane helices predicted for SG2461 by TMHMM2.0 at aa 31-53, 68-90, 151-173 and 220-242 550538011707 HMMPfam hit to PF04401, Protein of unknown function DUF540, score 1.2e-109 550538011708 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 550538011709 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 550538011710 dimer interface [polypeptide binding]; other site 550538011711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538011712 catalytic residue [active] 550538011713 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 2e-126 550538011714 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 550538011715 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 550538011716 dimerization domain swap beta strand [polypeptide binding]; other site 550538011717 regulatory protein interface [polypeptide binding]; other site 550538011718 active site 550538011719 regulatory phosphorylation site [posttranslational modification]; other site 550538011720 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 5.7e-49 550538011721 PS00369 PTS HPR component histidine phosphorylation site signature. 550538011722 PS00589 PTS HPR component serine phosphorylation site signature. 550538011723 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 550538011724 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 550538011725 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 550538011726 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 550538011727 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 4.7e-60 550538011728 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 2.6e-37 550538011729 PS00370 PEP-utilizing enzymes phosphorylation site signature. 550538011730 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 1.3e-193 550538011731 PS00742 PEP-utilizing enzymes signature 2. 550538011732 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 550538011733 HPr interaction site; other site 550538011734 glycerol kinase (GK) interaction site [polypeptide binding]; other site 550538011735 active site 550538011736 phosphorylation site [posttranslational modification] 550538011737 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 3.7e-81 550538011738 PS00371 PTS EIIA domains phosphorylation site signature 1. 550538011739 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538011740 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 550538011741 dimer interface [polypeptide binding]; other site 550538011742 pyridoxamine kinase; Validated; Region: PRK05756 550538011743 pyridoxal binding site [chemical binding]; other site 550538011744 ATP binding site [chemical binding]; other site 550538011745 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.2e-05 550538011746 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 550538011747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538011748 DNA-binding site [nucleotide binding]; DNA binding site 550538011749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538011750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538011751 homodimer interface [polypeptide binding]; other site 550538011752 catalytic residue [active] 550538011753 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.8e-24 550538011754 PS00043 Bacterial regulatory proteins, gntR family signature. 550538011755 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.3e-08 550538011756 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 550538011757 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 550538011758 catalytic triad [active] 550538011759 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.2e-06 550538011760 hypothetical protein; Provisional; Region: PRK10318 550538011761 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538011762 Sel1-like repeats; Region: SEL1; smart00671 550538011763 HMMPfam hit to PF08238, Sel1-like, score 0.85 550538011764 HMMPfam hit to PF08238, Sel1-like, score 0.73 550538011765 HMMPfam hit to PF08238, Sel1-like, score 4.4e-11 550538011766 cysteine synthase B; Region: cysM; TIGR01138 550538011767 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 550538011768 dimer interface [polypeptide binding]; other site 550538011769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538011770 catalytic residue [active] 550538011771 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 4.2e-112 550538011772 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 550538011773 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 550538011774 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 550538011775 Walker A/P-loop; other site 550538011776 ATP binding site [chemical binding]; other site 550538011777 Q-loop/lid; other site 550538011778 ABC transporter signature motif; other site 550538011779 Walker B; other site 550538011780 D-loop; other site 550538011781 H-loop/switch region; other site 550538011782 TOBE-like domain; Region: TOBE_3; pfam12857 550538011783 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-68 550538011784 PS00211 ABC transporters family signature. 550538011785 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011786 sulfate transport protein; Provisional; Region: cysT; CHL00187 550538011787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538011788 dimer interface [polypeptide binding]; other site 550538011789 conserved gate region; other site 550538011790 putative PBP binding loops; other site 550538011791 ABC-ATPase subunit interface; other site 550538011792 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.2e-16 550538011793 6 probable transmembrane helices predicted for SG2474 by TMHMM2.0 at aa 21-43, 63-91, 103-125, 140-162, 201-223 and 246-268 550538011794 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538011795 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 550538011796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538011797 dimer interface [polypeptide binding]; other site 550538011798 conserved gate region; other site 550538011799 putative PBP binding loops; other site 550538011800 ABC-ATPase subunit interface; other site 550538011801 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.4e-37 550538011802 7 probable transmembrane helices predicted for SG2475 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160, 188-205, 212-234 and 244-266 550538011803 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538011804 thiosulfate transporter subunit; Provisional; Region: PRK10852 550538011805 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 550538011806 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.4e-11 550538011807 PS00757 Prokaryotic sulfate-binding proteins signature 2. 550538011808 PS00401 Prokaryotic sulfate-binding proteins signature 1. 550538011809 PS00092 N-6 Adenine-specific DNA methylases signature. 550538011810 short chain dehydrogenase; Provisional; Region: PRK08226 550538011811 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 550538011812 NAD binding site [chemical binding]; other site 550538011813 homotetramer interface [polypeptide binding]; other site 550538011814 homodimer interface [polypeptide binding]; other site 550538011815 active site 550538011816 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 3.6e-40 550538011817 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 550538011818 HMMPfam hit to PF04261, Dyp-type peroxidase, score 1.1e-159 550538011819 the sequence has been checked and is believed to be correct 550538011820 HMMPfam hit to PF06572, Protein of unknown function DUF1131, score 4.1e-164 550538011821 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 550538011822 4 probable transmembrane helices predicted for SG2480 by TMHMM2.0 at aa 19-41, 61-78, 90-112 and 116-135 550538011823 putative acetyltransferase; Provisional; Region: PRK03624 550538011824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538011825 Coenzyme A binding pocket [chemical binding]; other site 550538011826 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.6e-22 550538011827 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 550538011828 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 550538011829 active site 550538011830 metal binding site [ion binding]; metal-binding site 550538011831 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 7.2e-108 550538011832 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 550538011833 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 550538011834 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 6.1e-243 550538011835 PS01021 Coproporphyrinogen III oxidase signature. 550538011836 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538011837 3 probable transmembrane helices predicted for SG2484 by TMHMM2.0 at aa 19-36, 51-73 and 86-108 550538011838 transcriptional regulator EutR; Provisional; Region: PRK10130 550538011839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538011840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538011841 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00012 550538011842 PS00041 Bacterial regulatory proteins, araC family signature. 550538011843 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.2e-10 550538011844 carboxysome structural protein EutK; Provisional; Region: PRK15466 550538011845 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 550538011846 Hexamer interface [polypeptide binding]; other site 550538011847 Hexagonal pore residue; other site 550538011848 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 7.4e-30 550538011849 PS01139 Bacterial microcompartiments proteins signature. 550538011850 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 550538011851 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 550538011852 putative hexamer interface [polypeptide binding]; other site 550538011853 putative hexagonal pore; other site 550538011854 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 550538011855 putative hexamer interface [polypeptide binding]; other site 550538011856 putative hexagonal pore; other site 550538011857 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 4.1e-12 550538011858 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 550538011859 HMMPfam hit to PF05985, Ethanolamine ammonia-lyase light chain, score 3.9e-152 550538011860 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 550538011861 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 550538011862 HMMPfam hit to PF06751, Ethanolamine ammonia lyase large subunit, score 0 550538011863 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 550538011864 HMMPfam hit to PF06277, Ethanolamine utilisation EutA, score 0 550538011865 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 550538011866 HMMPfam hit to PF04346, Ethanolamine utilisation protein, EutH, score 4.6e-280 550538011867 10 probable transmembrane helices predicted for SG2491 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 124-146, 153-175, 190-212, 231-253, 273-295, 308-330 and 370-392 550538011868 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 550538011869 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 550538011870 active site 550538011871 metal binding site [ion binding]; metal-binding site 550538011872 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.5e-207 550538011873 PS00060 Iron-containing alcohol dehydrogenases signature 2. 550538011874 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011875 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538011876 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538011877 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 550538011878 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538011879 nucleotide binding site [chemical binding]; other site 550538011880 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 550538011881 putative catalytic cysteine [active] 550538011882 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1e-10 550538011883 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 550538011884 Hexamer/Pentamer interface [polypeptide binding]; other site 550538011885 central pore; other site 550538011886 HMMPfam hit to PF03319, Ethanolamine utilization protein EutN/carboxysome structural protein Ccml, score 3.3e-50 550538011887 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 550538011888 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 550538011889 Hexamer interface [polypeptide binding]; other site 550538011890 Putative hexagonal pore residue; other site 550538011891 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.5e-40 550538011892 PS01139 Bacterial microcompartiments proteins signature. 550538011893 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 550538011894 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.2e-168 550538011895 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 550538011896 HMMPfam hit to PF01923, Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, score 1.4e-46 550538011897 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 550538011898 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 550538011899 HMMPfam hit to PF06249, Ethanolamine utilisation EutQ, score 2.9e-102 550538011900 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 550538011901 G1 box; other site 550538011902 GTP/Mg2+ binding site [chemical binding]; other site 550538011903 G2 box; other site 550538011904 Switch I region; other site 550538011905 G3 box; other site 550538011906 Switch II region; other site 550538011907 G4 box; other site 550538011908 G5 box; other site 550538011909 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011910 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 550538011911 putative hexamer interface [polypeptide binding]; other site 550538011912 putative hexagonal pore; other site 550538011913 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.7e-16 550538011914 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 550538011915 Malic enzyme, N-terminal domain; Region: malic; pfam00390 550538011916 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 550538011917 putative NAD(P) binding site [chemical binding]; other site 550538011918 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 550538011919 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.2e-114 550538011920 HMMPfam hit to PF03949, Malic enzyme, NAD-binding, score 1.4e-127 550538011921 HMMPfam hit to PF00390, Malic enzyme, N-terminal, score 6e-78 550538011922 transaldolase-like protein; Provisional; Region: PTZ00411 550538011923 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 550538011924 active site 550538011925 dimer interface [polypeptide binding]; other site 550538011926 catalytic residue [active] 550538011927 HMMPfam hit to PF00923, Transaldolase, score 1.6e-181 550538011928 PS01054 Transaldolase signature 1. 550538011929 transketolase; Reviewed; Region: PRK12753 550538011930 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 550538011931 TPP-binding site [chemical binding]; other site 550538011932 dimer interface [polypeptide binding]; other site 550538011933 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 550538011934 PYR/PP interface [polypeptide binding]; other site 550538011935 dimer interface [polypeptide binding]; other site 550538011936 TPP binding site [chemical binding]; other site 550538011937 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 550538011938 HMMPfam hit to PF00456, Transketolase, N-terminal, score 1.2e-256 550538011939 PS00801 Transketolase signature 1. 550538011940 HMMPfam hit to PF02779, Transketolase, central region, score 1.1e-71 550538011941 PS00802 Transketolase signature 2. 550538011942 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.8e-14 550538011943 PS00190 Cytochrome c family heme-binding site signature. 550538011944 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 550538011945 HMMPfam hit to PF06674, Protein of unknown function DUF1176, score 8.4e-213 550538011946 1 probable transmembrane helix predicted for SG2506 by TMHMM2.0 at aa 5-24 550538011947 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 550538011948 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 550538011949 dimer interface [polypeptide binding]; other site 550538011950 ADP-ribose binding site [chemical binding]; other site 550538011951 active site 550538011952 nudix motif; other site 550538011953 metal binding site [ion binding]; metal-binding site 550538011954 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 9.3e-19 550538011955 PS00017 ATP/GTP-binding site motif A (P-loop). 550538011956 putative periplasmic esterase; Provisional; Region: PRK03642 550538011957 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 550538011958 HMMPfam hit to PF00144, Beta-lactamase, score 5e-69 550538011959 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 550538011960 4Fe-4S binding domain; Region: Fer4; pfam00037 550538011961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 550538011962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538011963 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 6.4e-20 550538011964 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 0.0035 550538011965 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1e-06 550538011966 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538011967 PS00430 TonB-dependent receptor proteins signature 1. 550538011968 PS00190 Cytochrome c family heme-binding site signature. 550538011969 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 550538011970 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 550538011971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538011972 dimerization interface [polypeptide binding]; other site 550538011973 Histidine kinase; Region: HisKA_3; pfam07730 550538011974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538011975 ATP binding site [chemical binding]; other site 550538011976 Mg2+ binding site [ion binding]; other site 550538011977 G-X-G motif; other site 550538011978 2 probable transmembrane helices predicted for SG2510 by TMHMM2.0 at aa 15-37 and 147-169 550538011979 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3e-13 550538011980 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 2.3e-19 550538011981 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.4e-21 550538011982 the sequence has been checked and is believed to be correct 550538011983 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 550538011984 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 550538011985 ArsC family; Region: ArsC; pfam03960 550538011986 putative catalytic residues [active] 550538011987 HMMPfam hit to PF03960, Arsenate reductase and related, score 2.1e-45 550538011988 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 550538011989 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 550538011990 metal binding site [ion binding]; metal-binding site 550538011991 dimer interface [polypeptide binding]; other site 550538011992 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 550538011993 HMMPfam hit to PF01546, Peptidase M20, score 1.9e-53 550538011994 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 550538011995 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 3.3e-35 550538011996 hypothetical protein; Provisional; Region: PRK13664 550538011997 1 probable transmembrane helix predicted for SG2514 by TMHMM2.0 at aa 5-24 550538011998 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 550538011999 Helicase; Region: Helicase_RecD; pfam05127 550538012000 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 550538012001 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 550538012002 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0004 550538012003 HMMPfam hit to PF05127, Protein of unknown function DUF699, ATPase , score 3.8e-51 550538012004 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012005 Predicted metalloprotease [General function prediction only]; Region: COG2321 550538012006 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 550538012007 HMMPfam hit to PF04228, Protein of unknown function, zinc metallopeptidase , score 2.5e-243 550538012008 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538012009 1 probable transmembrane helix predicted for SG2516 by TMHMM2.0 at aa 38-60 550538012010 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 550538012011 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 550538012012 ATP binding site [chemical binding]; other site 550538012013 active site 550538012014 substrate binding site [chemical binding]; other site 550538012015 HMMPfam hit to PF01259, SAICAR synthetase, score 4.7e-123 550538012016 PS01058 SAICAR synthetase signature 2. 550538012017 PS01057 SAICAR synthetase signature 1. 550538012018 lipoprotein; Provisional; Region: PRK11679 550538012019 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 550538012020 HMMPfam hit to PF06804, NlpBDapX lipoprotein, score 5.7e-197 550538012021 PS00572 Glycosyl hydrolases family 1 active site. 550538012022 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 550538012023 dihydrodipicolinate synthase; Region: dapA; TIGR00674 550538012024 dimer interface [polypeptide binding]; other site 550538012025 active site 550538012026 catalytic residue [active] 550538012027 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 5.2e-172 550538012028 PS00666 Dihydrodipicolinate synthetase signature 2. 550538012029 PS00665 Dihydrodipicolinate synthetase signature 1. 550538012030 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 550538012031 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 550538012032 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 550538012033 HMMPfam hit to PF01842, Amino acid-binding ACT, score 7.5e-05 550538012034 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.012 550538012035 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 550538012036 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 550538012037 catalytic triad [active] 550538012038 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 2.7e-50 550538012039 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 550538012040 HMMPfam hit to PF02595, Glycerate kinase, score 6.8e-225 550538012041 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 550538012042 fructuronate transporter; Provisional; Region: PRK10034; cl15264 550538012043 11 probable transmembrane helices predicted for SG2523 by TMHMM2.0 at aa 5-27, 34-56, 71-93, 106-128, 179-201, 222-244, 249-268, 281-303, 313-335, 348-370 and 409-428 550538012044 HMMPfam hit to PF03600, Divalent ion symporter, score 1.4e-07 550538012045 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 550538012046 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 550538012047 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 550538012048 HMMPfam hit to PF05651, sugar diacid recognition, score 1.4e-121 550538012049 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 550538012050 Domain of unknown function DUF20; Region: UPF0118; pfam01594 550538012051 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 4.4e-104 550538012052 7 probable transmembrane helices predicted for SG2525 by TMHMM2.0 at aa 20-51, 71-93, 155-177, 217-236, 251-273, 278-300 and 310-332 550538012053 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 550538012054 Peptidase family M48; Region: Peptidase_M48; cl12018 550538012055 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 7.1e-30 550538012056 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 550538012057 ArsC family; Region: ArsC; pfam03960 550538012058 catalytic residues [active] 550538012059 HMMPfam hit to PF03960, Arsenate reductase and related, score 6e-45 550538012060 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 550538012061 DNA replication initiation factor; Provisional; Region: PRK08084 550538012062 HMMPfam hit to PF00308, Chromosomal replication initiator, DnaA, score 1.8e-06 550538012063 uracil transporter; Provisional; Region: PRK10720 550538012064 12 probable transmembrane helices predicted for SG2529 by TMHMM2.0 at aa 13-35, 39-61, 68-85, 89-108, 121-143, 158-180, 185-207, 227-249, 304-326, 331-353, 365-387 and 392-411 550538012065 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 1e-143 550538012066 PS01116 Xanthine/uracil permeases family signature. 550538012067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538012068 active site 550538012069 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 4.7e-13 550538012070 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 550538012071 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 550538012072 dimerization interface [polypeptide binding]; other site 550538012073 putative ATP binding site [chemical binding]; other site 550538012074 HMMPfam hit to PF00586, AIR synthase related protein, score 6.1e-74 550538012075 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 8.6e-52 550538012076 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 550538012077 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 550538012078 active site 550538012079 substrate binding site [chemical binding]; other site 550538012080 cosubstrate binding site; other site 550538012081 catalytic site [active] 550538012082 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 4.6e-86 550538012083 PS00373 Phosphoribosylglycinamide formyltransferase active site. 550538012084 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 550538012085 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 550538012086 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 550538012087 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 550538012088 putative active site [active] 550538012089 catalytic site [active] 550538012090 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 550538012091 domain interface [polypeptide binding]; other site 550538012092 active site 550538012093 catalytic site [active] 550538012094 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 550538012095 exopolyphosphatase; Provisional; Region: PRK10854 550538012096 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538012097 nucleotide binding site [chemical binding]; other site 550538012098 HMMPfam hit to PF02541, Ppx/GppA phosphatase, score 1.3e-138 550538012099 MASE1; Region: MASE1; pfam05231 550538012100 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 550538012101 diguanylate cyclase; Region: GGDEF; smart00267 550538012102 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538012103 HMMPfam hit to PF00563, EAL, score 3.5e-108 550538012104 HMMPfam hit to PF05231, MASE1, score 9.6e-81 550538012105 9 probable transmembrane helices predicted for SG2535 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 124-146, 166-188, 216-235, 240-259, 266-288 and 293-315 550538012106 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 550538012107 HMMPfam hit to PF07377, Protein of unknown function DUF1493, score 2.6e-67 550538012108 Integrase core domain; Region: rve; pfam00665 550538012109 HMMPfam hit to PF00665, Integrase, catalytic core, score 2.6e-20 550538012110 GMP synthase; Reviewed; Region: guaA; PRK00074 550538012111 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 550538012112 AMP/PPi binding site [chemical binding]; other site 550538012113 candidate oxyanion hole; other site 550538012114 catalytic triad [active] 550538012115 potential glutamine specificity residues [chemical binding]; other site 550538012116 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 550538012117 ATP Binding subdomain [chemical binding]; other site 550538012118 Ligand Binding sites [chemical binding]; other site 550538012119 Dimerization subdomain; other site 550538012120 HMMPfam hit to PF00958, GMP synthase, C-terminal, score 3.5e-60 550538012121 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 7.3e-10 550538012122 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.4e-51 550538012123 PS00442 Glutamine amidotransferases class-I active site. 550538012124 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 550538012125 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 550538012126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 550538012127 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 550538012128 active site 550538012129 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 6e-247 550538012130 PS00487 IMP dehydrogenase / GMP reductase signature. 550538012131 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 4.3e-24 550538012132 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 550538012133 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 550538012134 generic binding surface II; other site 550538012135 generic binding surface I; other site 550538012136 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 3.3e-14 550538012137 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 4.2e-94 550538012139 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2e-33 550538012140 HMMPfam hit to PF03212, Pertactin, score 0.001 550538012141 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 2.2 550538012142 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 1.2 550538012144 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 2.6e-92 550538012145 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 3.2e-17 550538012146 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 3.9e-112 550538012147 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 4.8e-27 550538012148 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 1.2e-101 550538012149 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 7.4e-11 550538012150 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 9.1e-107 550538012151 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 1.2e-27 550538012152 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 3.9e-102 550538012153 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 5.7e-15 550538012154 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 2.5e-93 550538012155 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 1e-92 550538012156 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 4e-93 550538012157 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 7.6e-30 550538012158 outer membrane protein RatA; Provisional; Region: PRK15315 550538012159 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 550538012160 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 550538012161 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 550538012162 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 550538012163 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 550538012164 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 550538012165 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 550538012166 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 550538012167 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 550538012168 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 550538012169 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 550538012170 PS00294 Prenyl group binding site (CAAX box). 550538012171 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 9e-84 550538012172 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 4.3e-13 550538012173 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 4.3e-108 550538012174 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 2.5e-21 550538012175 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 7.3e-96 550538012176 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 1e-17 550538012177 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 6.4e-90 550538012178 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 3.7e-87 550538012179 HMMPfam hit to PF05689, Protein of unknown function DUF823, score 9.2e-90 550538012180 HMMPfam hit to PF05688, Protein of unknown function DUF824, score 7.2e-27 550538012181 1 probable transmembrane helix predicted for SG2549 by TMHMM2.0 at aa 13-32 550538012182 intimin-like protein SinH; Provisional; Region: PRK15318 550538012183 1 probable transmembrane helix predicted for SG2550 by TMHMM2.0 at aa 12-29 550538012185 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 550538012186 HMMPfam hit to PF07191, Protein of unknown function DUF1407, score 5.2e-52 550538012187 GTP-binding protein Der; Reviewed; Region: PRK00093 550538012188 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 550538012189 G1 box; other site 550538012190 GTP/Mg2+ binding site [chemical binding]; other site 550538012191 Switch I region; other site 550538012192 G2 box; other site 550538012193 Switch II region; other site 550538012194 G3 box; other site 550538012195 G4 box; other site 550538012196 G5 box; other site 550538012197 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 550538012198 G1 box; other site 550538012199 GTP/Mg2+ binding site [chemical binding]; other site 550538012200 Switch I region; other site 550538012201 G2 box; other site 550538012202 G3 box; other site 550538012203 Switch II region; other site 550538012204 G4 box; other site 550538012205 G5 box; other site 550538012206 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 6e-45 550538012207 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012208 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 7.2e-48 550538012209 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012210 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 550538012211 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 550538012212 Trp docking motif [polypeptide binding]; other site 550538012213 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 8.1e-07 550538012214 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.00066 550538012215 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 3.2e-05 550538012216 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 4.8e-08 550538012217 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538012218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 550538012219 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 550538012220 1 probable transmembrane helix predicted for SG2556 by TMHMM2.0 at aa 21-43 550538012221 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 550538012222 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 550538012223 dimer interface [polypeptide binding]; other site 550538012224 motif 1; other site 550538012225 active site 550538012226 motif 2; other site 550538012227 motif 3; other site 550538012228 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 550538012229 anticodon binding site; other site 550538012230 HMMPfam hit to PF03129, Anticodon-binding, score 6.9e-11 550538012231 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538012232 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 2.9e-57 550538012233 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 550538012234 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 550538012235 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 550538012236 HMMPfam hit to PF04551, IspG protein, score 2.3e-258 550538012237 cytoskeletal protein RodZ; Provisional; Region: PRK10856 550538012238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538012239 non-specific DNA binding site [nucleotide binding]; other site 550538012240 salt bridge; other site 550538012241 sequence-specific DNA binding site [nucleotide binding]; other site 550538012242 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 550538012243 1 probable transmembrane helix predicted for SG2559 by TMHMM2.0 at aa 111-133 550538012244 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.5e-08 550538012245 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 550538012246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538012247 FeS/SAM binding site; other site 550538012248 HMMPfam hit to PF04055, Radical SAM, score 4.3e-17 550538012249 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 550538012250 active site 550538012251 multimer interface [polypeptide binding]; other site 550538012252 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, core, score 1.3e-91 550538012253 PS00469 Nucleoside diphosphate kinases active site. 550538012254 4Fe-4S binding domain; Region: Fer4; pfam00037 550538012255 hydrogenase 4 subunit H; Validated; Region: PRK08222 550538012256 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 8.1e-06 550538012257 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538012258 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.4e-05 550538012259 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538012260 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.2e-07 550538012261 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538012262 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 550538012263 8 probable transmembrane helices predicted for SG2563 by TMHMM2.0 at aa 4-26, 39-61, 84-103, 110-132, 142-164, 171-193, 221-240 and 247-266 550538012264 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 3.8e-15 550538012265 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 550538012266 4Fe-4S binding domain; Region: Fer4; pfam00037 550538012267 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.1e-08 550538012268 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538012269 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 550538012270 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 550538012271 putative [Fe4-S4] binding site [ion binding]; other site 550538012272 putative molybdopterin cofactor binding site [chemical binding]; other site 550538012273 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 550538012274 putative molybdopterin cofactor binding site; other site 550538012275 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 1.2e-35 550538012276 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 6.9e-75 550538012277 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538012278 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 7.5e-06 550538012279 penicillin-binding protein 1C; Provisional; Region: PRK11240 550538012280 Transglycosylase; Region: Transgly; pfam00912 550538012281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 550538012282 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 550538012283 HMMPfam hit to PF06832, Penicillin-binding, C-terminal, score 2.2e-32 550538012284 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.5e-10 550538012285 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 6.5e-80 550538012286 1 probable transmembrane helix predicted for SG2566 by TMHMM2.0 at aa 9-28 550538012287 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 550538012288 MG2 domain; Region: A2M_N; pfam01835 550538012289 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 550538012290 surface patch; other site 550538012291 thioester region; other site 550538012292 specificity defining residues; other site 550538012293 HMMPfam hit to PF07703, Alpha-2-macroglobulin, N-terminal 2, score 2.9e-30 550538012294 HMMPfam hit to PF01835, Alpha-2-macroglobulin, N-terminal, score 5.8e-90 550538012295 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538012296 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 550538012297 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 550538012298 active site residue [active] 550538012299 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 550538012300 active site residue [active] 550538012301 HMMPfam hit to PF00581, Rhodanese-like, score 2.7e-36 550538012302 PS00380 Rhodanese signature 1. 550538012303 HMMPfam hit to PF00581, Rhodanese-like, score 3.2e-27 550538012304 PS00683 Rhodanese C-terminal signature. 550538012305 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 550538012306 HMMPfam hit to PF07179, SseB, score 3.3e-200 550538012307 aminopeptidase B; Provisional; Region: PRK05015 550538012308 Peptidase; Region: DUF3663; pfam12404 550538012309 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 550538012310 interface (dimer of trimers) [polypeptide binding]; other site 550538012311 Substrate-binding/catalytic site; other site 550538012312 Zn-binding sites [ion binding]; other site 550538012313 HMMPfam hit to PF00883, Peptidase M17, leucyl aminopeptidase, C-terminal, score 1.2e-174 550538012314 PS00631 Cytosol aminopeptidase signature. 550538012315 hypothetical protein; Provisional; Region: PRK10721 550538012316 HMMPfam hit to PF04384, ISC system FeS cluster assembly, IscX, score 3.4e-47 550538012317 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 550538012318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 550538012319 catalytic loop [active] 550538012320 iron binding site [ion binding]; other site 550538012321 HMMPfam hit to PF00111, Ferredoxin, score 9e-24 550538012322 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 550538012323 chaperone protein HscA; Provisional; Region: hscA; PRK05183 550538012324 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 550538012325 nucleotide binding site [chemical binding]; other site 550538012326 putative NEF/HSP70 interaction site [polypeptide binding]; other site 550538012327 SBD interface [polypeptide binding]; other site 550538012328 HMMPfam hit to PF00012, Heat shock protein 70, score 1.1e-278 550538012329 PS01036 Heat shock hsp70 proteins family signature 3. 550538012330 PS00329 Heat shock hsp70 proteins family signature 2. 550538012331 PS00297 Heat shock hsp70 proteins family signature 1. 550538012332 co-chaperone HscB; Provisional; Region: hscB; PRK05014 550538012333 DnaJ domain; Region: DnaJ; pfam00226 550538012334 HSP70 interaction site [polypeptide binding]; other site 550538012335 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 550538012336 HMMPfam hit to PF07743, Heat shock cognate protein B, C-terminal oligomerisation, score 1.6e-29 550538012337 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 2.8e-12 550538012338 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 550538012339 PS01152 Hypothetical hesB/yadR/yfhF family signature. 550538012340 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 3.8e-44 550538012341 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 550538012342 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 550538012343 trimerization site [polypeptide binding]; other site 550538012344 active site 550538012345 HMMPfam hit to PF01592, NIF system FeS cluster assembly, NifU, N-terminal, score 2.4e-83 550538012346 cysteine desulfurase; Provisional; Region: PRK14012 550538012347 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 550538012348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538012349 catalytic residue [active] 550538012350 HMMPfam hit to PF00266, Aminotransferase, class V, score 2.1e-125 550538012351 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 550538012352 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 550538012353 Rrf2 family protein; Region: rrf2_super; TIGR00738 550538012354 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 2.9e-52 550538012355 PS01332 Uncharacterized protein family UPF0074 signature. 550538012356 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 550538012357 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 550538012358 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 1.1e-36 550538012359 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 550538012360 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 550538012361 active site 550538012362 dimerization interface [polypeptide binding]; other site 550538012363 HMMPfam hit to PF00459, Inositol monophosphatase, score 7.2e-117 550538012364 PS00629 Inositol monophosphatase family signature 1. 550538012365 PS00630 Inositol monophosphatase family signature 2. 550538012366 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 550538012367 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 550538012368 1 probable transmembrane helix predicted for SG2582 by TMHMM2.0 at aa 13-35 550538012369 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 2.5e-06 550538012371 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0073 550538012372 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 550538012373 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 550538012374 FAD binding pocket [chemical binding]; other site 550538012375 FAD binding motif [chemical binding]; other site 550538012376 phosphate binding motif [ion binding]; other site 550538012377 beta-alpha-beta structure motif; other site 550538012378 NAD binding pocket [chemical binding]; other site 550538012379 Iron coordination center [ion binding]; other site 550538012380 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 9.6e-08 550538012381 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 3.6e-27 550538012382 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 550538012383 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 550538012384 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 550538012385 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 2.2e-09 550538012386 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S region, score 1.7e-28 550538012387 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 550538012388 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.2e-05 550538012389 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.3e-06 550538012390 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538012392 HMMPfam hit to PF03824, Nickel/cobalt transporter, high-affinity, score 1.2e-89 550538012393 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 550538012394 HMMPfam hit to PF06226, Protein of unknown function DUF1007, score 3.2e-126 550538012395 1 probable transmembrane helix predicted for SG2589 by TMHMM2.0 at aa 7-24 550538012396 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 550538012397 PRD domain; Region: PRD; pfam00874 550538012398 PRD domain; Region: PRD; pfam00874 550538012399 HMMPfam hit to PF00874, PRD, score 2.3e-15 550538012400 HMMPfam hit to PF00874, PRD, score 3e-14 550538012401 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 550538012402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538012403 putative substrate translocation pore; other site 550538012404 12 probable transmembrane helices predicted for SG2591 by TMHMM2.0 at aa 9-31, 41-63, 70-89, 93-111, 132-154, 158-180, 207-229, 234-256, 269-288, 293-315, 328-350 and 354-371 550538012405 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 9.1e-18 550538012406 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 550538012407 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 550538012408 dimer interface [polypeptide binding]; other site 550538012409 active site 550538012410 glycine-pyridoxal phosphate binding site [chemical binding]; other site 550538012411 folate binding site [chemical binding]; other site 550538012412 HMMPfam hit to PF00464, Glycine hydroxymethyltransferase, score 1.9e-287 550538012413 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 550538012414 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 550538012415 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 550538012416 heme-binding site [chemical binding]; other site 550538012417 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 550538012418 FAD binding pocket [chemical binding]; other site 550538012419 FAD binding motif [chemical binding]; other site 550538012420 phosphate binding motif [ion binding]; other site 550538012421 beta-alpha-beta structure motif; other site 550538012422 NAD binding pocket [chemical binding]; other site 550538012423 Heme binding pocket [chemical binding]; other site 550538012424 HMMPfam hit to PF00042, Globin, subset, score 1.1e-27 550538012425 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 4e-12 550538012426 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 1.3e-19 550538012427 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 550538012428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538012429 DNA binding site [nucleotide binding] 550538012430 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.7e-19 550538012431 1 probable transmembrane helix predicted for SG2594 by TMHMM2.0 at aa 161-183 550538012432 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 550538012433 12 probable transmembrane helices predicted for SG2595 by TMHMM2.0 at aa 7-29, 39-58, 93-115, 120-142, 149-171, 186-208, 220-242, 265-287, 322-344, 354-371, 384-403 and 407-424 550538012434 HMMPfam hit to PF00324, Amino acid permease-associated region, score 4.8e-05 550538012435 lysine decarboxylase CadA; Provisional; Region: PRK15400 550538012436 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 550538012437 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 550538012438 homodimer interface [polypeptide binding]; other site 550538012439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538012440 catalytic residue [active] 550538012441 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 550538012442 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 2.2e-44 550538012443 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 9e-297 550538012444 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 550538012445 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 3.7e-84 550538012446 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 550538012447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538012448 putative substrate translocation pore; other site 550538012449 POT family; Region: PTR2; pfam00854 550538012450 14 probable transmembrane helices predicted for SG2597 by TMHMM2.0 at aa 9-31, 46-68, 71-93, 103-125, 138-160, 164-186, 207-229, 234-251, 264-281, 307-329, 341-363, 373-395, 407-429 and 449-471 550538012451 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 550538012452 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538012453 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 1.9e-87 550538012454 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 550538012455 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 550538012456 Nitrogen regulatory protein P-II; Region: P-II; smart00938 550538012457 HMMPfam hit to PF00543, Nitrogen regulatory protein PII, score 7.2e-79 550538012458 PS00638 P-II protein C-terminal region signature. 550538012459 PS00496 P-II protein urydylation site. 550538012460 response regulator GlrR; Provisional; Region: PRK15115 550538012461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538012462 active site 550538012463 phosphorylation site [posttranslational modification] 550538012464 intermolecular recognition site; other site 550538012465 dimerization interface [polypeptide binding]; other site 550538012466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538012467 Walker A motif; other site 550538012468 ATP binding site [chemical binding]; other site 550538012469 Walker B motif; other site 550538012470 arginine finger; other site 550538012471 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538012472 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 2.2e-150 550538012473 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538012474 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538012475 HMMPfam hit to PF00072, Response regulator receiver, score 3.7e-46 550538012476 hypothetical protein; Provisional; Region: PRK10722 550538012477 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538012478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 550538012479 HAMP domain; Region: HAMP; pfam00672 550538012480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538012481 dimer interface [polypeptide binding]; other site 550538012482 phosphorylation site [posttranslational modification] 550538012483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538012484 ATP binding site [chemical binding]; other site 550538012485 Mg2+ binding site [ion binding]; other site 550538012486 G-X-G motif; other site 550538012487 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4e-28 550538012488 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.3e-18 550538012489 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1e-08 550538012490 2 probable transmembrane helices predicted for SG2601 by TMHMM2.0 at aa 15-37 and 179-201 550538012491 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 550538012492 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 550538012493 dimerization interface [polypeptide binding]; other site 550538012494 ATP binding site [chemical binding]; other site 550538012495 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 550538012496 dimerization interface [polypeptide binding]; other site 550538012497 ATP binding site [chemical binding]; other site 550538012498 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 550538012499 putative active site [active] 550538012500 catalytic triad [active] 550538012501 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 7.2e-26 550538012502 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 5.9e-34 550538012503 HMMPfam hit to PF00586, AIR synthase related protein, score 2.3e-49 550538012504 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 550538012505 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538012506 substrate binding pocket [chemical binding]; other site 550538012507 membrane-bound complex binding site; other site 550538012508 hinge residues; other site 550538012509 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538012510 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538012511 catalytic residue [active] 550538012512 1 probable transmembrane helix predicted for SG2604 by TMHMM2.0 at aa 7-29 550538012513 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 3e-38 550538012514 PS00922 Prokaryotic transglycosylases signature. 550538012515 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 550538012516 nucleoside/Zn binding site; other site 550538012517 dimer interface [polypeptide binding]; other site 550538012518 catalytic motif [active] 550538012519 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 5.2e-46 550538012520 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 550538012521 hypothetical protein; Provisional; Region: PRK11590 550538012522 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 550538012523 1 probable transmembrane helix predicted for SG2606 by TMHMM2.0 at aa 35-54 550538012524 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 550538012525 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 550538012526 active site turn [active] 550538012527 phosphorylation site [posttranslational modification] 550538012528 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 550538012529 9 probable transmembrane helices predicted for SG2607 by TMHMM2.0 at aa 117-139, 154-176, 214-231, 246-268, 288-310, 325-346, 359-381, 396-418 and 425-447 550538012530 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.7e-35 550538012531 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 2.1e-10 550538012532 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 550538012533 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 550538012534 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 550538012535 putative active site [active] 550538012536 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.8e-08 550538012537 PS01272 Glucokinase regulatory protein family signature. 550538012538 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 550538012539 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 550538012540 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 550538012541 putative active site [active] 550538012542 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 4.3e-52 550538012543 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 2.8e-33 550538012544 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 550538012545 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 550538012546 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 550538012547 HMMPfam hit to PF08546, Ketopantoate reductase ApbA/PanE, C-terminal, score 1.9e-54 550538012548 HMMPfam hit to PF02558, Ketopantoate reductase ApbA/PanE, N-terminal, score 2.2e-36 550538012549 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 550538012550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538012551 putative substrate translocation pore; other site 550538012552 12 probable transmembrane helices predicted for SG2611 by TMHMM2.0 at aa 10-29, 42-64, 74-93, 98-115, 130-152, 165-184, 213-235, 242-264, 274-296, 301-323, 338-357 and 364-386 550538012553 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 4e-48 550538012554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538012555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538012556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538012557 dimerization interface [polypeptide binding]; other site 550538012558 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.5e-16 550538012559 PS00044 Bacterial regulatory proteins, lysR family signature. 550538012560 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.1e-29 550538012561 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 550538012562 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2e-05 550538012563 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538012564 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 550538012565 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 2.5e-22 550538012566 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 550538012567 active site 550538012568 hydrophilic channel; other site 550538012569 dimerization interface [polypeptide binding]; other site 550538012570 catalytic residues [active] 550538012571 active site lid [active] 550538012572 HMMPfam hit to PF03740, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ, score 2.6e-148 550538012573 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 550538012574 Recombination protein O N terminal; Region: RecO_N; pfam11967 550538012575 Recombination protein O C terminal; Region: RecO_C; pfam02565 550538012576 HMMPfam hit to PF02565, Recombination protein O, RecO, score 3.2e-116 550538012577 GTPase Era; Reviewed; Region: era; PRK00089 550538012578 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 550538012579 G1 box; other site 550538012580 GTP/Mg2+ binding site [chemical binding]; other site 550538012581 Switch I region; other site 550538012582 G2 box; other site 550538012583 Switch II region; other site 550538012584 G3 box; other site 550538012585 G4 box; other site 550538012586 G5 box; other site 550538012587 KH domain; Region: KH_2; pfam07650 550538012588 HMMPfam hit to PF07650, K Homology, type 2, score 1e-25 550538012589 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.5e-39 550538012590 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012591 ribonuclease III; Reviewed; Region: rnc; PRK00102 550538012592 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 550538012593 dimerization interface [polypeptide binding]; other site 550538012594 active site 550538012595 metal binding site [ion binding]; metal-binding site 550538012596 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 550538012597 dsRNA binding site [nucleotide binding]; other site 550538012598 HMMPfam hit to PF00035, Double-stranded RNA binding, score 2.7e-17 550538012599 HMMPfam hit to PF00636, Ribonuclease III, score 2.2e-45 550538012600 PS00517 Ribonuclease III family signature. 550538012601 signal peptidase I; Provisional; Region: PRK10861 550538012602 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 550538012603 Catalytic site [active] 550538012604 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 550538012605 PS00761 Signal peptidases I signature 3. 550538012606 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 2.1e-24 550538012607 PS00760 Signal peptidases I lysine active site. 550538012608 PS00501 Signal peptidases I serine active site. 550538012609 2 probable transmembrane helices predicted for SG2619 by TMHMM2.0 at aa 5-27 and 60-82 550538012610 GTP-binding protein LepA; Provisional; Region: PRK05433 550538012611 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 550538012612 G1 box; other site 550538012613 putative GEF interaction site [polypeptide binding]; other site 550538012614 GTP/Mg2+ binding site [chemical binding]; other site 550538012615 Switch I region; other site 550538012616 G2 box; other site 550538012617 G3 box; other site 550538012618 Switch II region; other site 550538012619 G4 box; other site 550538012620 G5 box; other site 550538012621 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 550538012622 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 550538012623 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 550538012624 HMMPfam hit to PF06421, GTP-binding protein LepA, C-terminal, score 5.3e-79 550538012625 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 3.3e-32 550538012626 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.3e-11 550538012627 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.7e-73 550538012628 PS00301 GTP-binding elongation factors signature. 550538012629 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012630 SoxR reducing system protein RseC; Provisional; Region: PRK10862 550538012631 HMMPfam hit to PF04246, Positive regulator of sigma(E), RseC/MucC, score 1.6e-70 550538012632 2 probable transmembrane helices predicted for SG2621 by TMHMM2.0 at aa 78-100 and 104-121 550538012633 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 550538012634 anti-sigma E factor; Provisional; Region: rseB; PRK09455 550538012635 HMMPfam hit to PF03888, MucB/RseB, score 7.4e-203 550538012636 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 550538012637 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 550538012638 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 550538012639 HMMPfam hit to PF03873, Anti sigma-E protein RseA, C-terminal, score 7.9e-25 550538012640 HMMPfam hit to PF03872, Anti sigma-E protein RseA, N-terminal, score 2.1e-56 550538012641 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 550538012642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 550538012643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 550538012644 DNA binding residues [nucleotide binding] 550538012645 HMMPfam hit to PF08281, RNA polymerase sigma factor 70, region 4 type 2, score 1.5e-21 550538012646 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 8.6e-21 550538012647 PS01063 Sigma-70 factors ECF subfamily signature. 550538012648 L-aspartate oxidase; Provisional; Region: PRK09077 550538012649 L-aspartate oxidase; Provisional; Region: PRK06175 550538012650 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 550538012651 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 1.3e-139 550538012652 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 9e-07 550538012653 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 550538012654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538012655 S-adenosylmethionine binding site [chemical binding]; other site 550538012656 HMMPfam hit to PF05175, Methyltransferase small, score 7e-06 550538012657 PS00092 N-6 Adenine-specific DNA methylases signature. 550538012658 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 550538012659 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 550538012660 ATP binding site [chemical binding]; other site 550538012661 Mg++ binding site [ion binding]; other site 550538012662 motif III; other site 550538012663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538012664 nucleotide binding region [chemical binding]; other site 550538012665 ATP-binding site [chemical binding]; other site 550538012666 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.6e-71 550538012667 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012668 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 550538012669 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 2.4e-31 550538012670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538012671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538012672 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538012673 dimerization interface [polypeptide binding]; other site 550538012674 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-43 550538012675 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 7.1e-14 550538012676 PS00044 Bacterial regulatory proteins, lysR family signature. 550538012677 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 550538012678 6 probable transmembrane helices predicted for SG2629 by TMHMM2.0 at aa 10-32, 44-66, 70-92, 105-127, 142-164 and 177-194 550538012679 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 0.00086 550538012680 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 550538012681 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 2.9e-51 550538012682 PS00850 Glycine radical signature. 550538012683 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 550538012684 ligand binding site [chemical binding]; other site 550538012685 active site 550538012686 UGI interface [polypeptide binding]; other site 550538012687 catalytic site [active] 550538012688 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 1.9e-85 550538012689 PS00130 Uracil-DNA glycosylase signature. 550538012690 putative methyltransferase; Provisional; Region: PRK10864 550538012691 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 550538012692 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 550538012693 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 2e-39 550538012694 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate binding, score 5.2e-14 550538012695 thioredoxin 2; Provisional; Region: PRK10996 550538012696 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 550538012697 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 550538012698 catalytic residues [active] 550538012699 HMMPfam hit to PF00085, Thioredoxin domain, score 3.5e-35 550538012700 Uncharacterized conserved protein [Function unknown]; Region: COG3148 550538012701 HMMPfam hit to PF03942, DTW, score 2.2e-83 550538012702 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 550538012703 CoA binding domain; Region: CoA_binding_2; pfam13380 550538012704 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 550538012705 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 550538012706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 550538012707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538012708 Coenzyme A binding pocket [chemical binding]; other site 550538012709 HMMPfam hit to PF02629, CoA-binding, score 0.00028 550538012710 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-14 550538012711 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 550538012712 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 550538012713 domain interface [polypeptide binding]; other site 550538012714 putative active site [active] 550538012715 catalytic site [active] 550538012716 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 550538012717 domain interface [polypeptide binding]; other site 550538012718 putative active site [active] 550538012719 catalytic site [active] 550538012720 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 5.2e-06 550538012721 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 1.2e-07 550538012722 lipoprotein; Provisional; Region: PRK10759 550538012723 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 550538012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538012725 putative substrate translocation pore; other site 550538012726 HMMPfam hit to PF00083, General substrate transporter, score 2.9e-26 550538012727 12 probable transmembrane helices predicted for SG2638 by TMHMM2.0 at aa 21-43, 63-85, 97-114, 119-141, 161-183, 198-215, 245-267, 282-304, 311-328, 338-360, 373-395 and 405-424 550538012728 PS00217 Sugar transport proteins signature 2. 550538012729 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 550538012730 protein disaggregation chaperone; Provisional; Region: PRK10865 550538012731 Clp amino terminal domain; Region: Clp_N; pfam02861 550538012732 Clp amino terminal domain; Region: Clp_N; pfam02861 550538012733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538012734 Walker A motif; other site 550538012735 ATP binding site [chemical binding]; other site 550538012736 Walker B motif; other site 550538012737 arginine finger; other site 550538012738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538012739 Walker A motif; other site 550538012740 ATP binding site [chemical binding]; other site 550538012741 Walker B motif; other site 550538012742 arginine finger; other site 550538012743 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 550538012744 HMMPfam hit to PF07724, ATPase AAA-2, score 6.1e-112 550538012745 PS00871 Chaperonins clpA/B signature 2. 550538012746 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012747 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012748 PS00870 Chaperonins clpA/B signature 1. 550538012749 HMMPfam hit to PF00004, AAA ATPase, core, score 4.2e-12 550538012750 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012751 HMMPfam hit to PF02861, Clp, N-terminal, score 1.2e-13 550538012752 HMMPfam hit to PF02861, Clp, N-terminal, score 1.4e-16 550538012753 hypothetical protein; Provisional; Region: PRK10723 550538012754 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 550538012755 HMMPfam hit to PF02578, Protein of unknown function DUF152, score 6.7e-112 550538012756 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 550538012757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538012758 RNA binding surface [nucleotide binding]; other site 550538012759 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 550538012760 active site 550538012761 HMMPfam hit to PF00849, Pseudouridine synthase, score 7.5e-68 550538012762 PS01129 Rlu family of pseudouridine synthase signature. 550538012763 HMMPfam hit to PF01479, RNA-binding S4, score 3.7e-13 550538012764 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 550538012765 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 550538012766 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538012767 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 550538012768 30S subunit binding site; other site 550538012769 HMMPfam hit to PF02482, Ribosomal protein S30Ae/sigma 54 modulation protein, score 7.8e-49 550538012770 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 550538012771 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 550538012772 Prephenate dehydratase; Region: PDT; pfam00800 550538012773 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 550538012774 putative L-Phe binding site [chemical binding]; other site 550538012775 HMMPfam hit to PF01817, Chorismate mutase, score 1.8e-29 550538012776 HMMPfam hit to PF00800, Prephenate dehydratase, score 5.3e-89 550538012777 PS00858 Prephenate dehydratase signature 2. 550538012778 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 550538012779 HMMPfam hit to PF08450, SMP-30/Gluconolaconase/LRE-like region, score 4.1e-115 550538012780 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 550538012781 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 550538012782 prephenate dehydrogenase; Validated; Region: PRK08507 550538012783 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 1.6e-18 550538012784 HMMPfam hit to PF01817, Chorismate mutase, score 9.1e-18 550538012785 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 550538012786 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 550538012787 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 1.4e-173 550538012788 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 550538012789 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 550538012790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538012791 metal binding site [ion binding]; metal-binding site 550538012792 active site 550538012793 I-site; other site 550538012794 2 probable transmembrane helices predicted for SG2650 by TMHMM2.0 at aa 21-43 and 153-175 550538012795 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 8e-07 550538012796 HMMPfam hit to PF00990, GGDEF, score 1.5e-50 550538012797 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 550538012798 HMMPfam hit to PF01245, Ribosomal protein L19, score 1.3e-82 550538012799 PS01015 Ribosomal protein L19 signature. 550538012800 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 550538012801 HMMPfam hit to PF01746, tRNA (guanine-N1-)-methyltransferase, score 3.4e-93 550538012802 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 550538012803 RimM N-terminal domain; Region: RimM; pfam01782 550538012804 PRC-barrel domain; Region: PRC; pfam05239 550538012805 HMMPfam hit to PF05239, PRC-barrel, score 1.9e-13 550538012806 HMMPfam hit to PF01782, RimM protein, score 1.9e-37 550538012807 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 550538012808 HMMPfam hit to PF00886, Ribosomal protein S16, score 2.9e-35 550538012809 PS00732 Ribosomal protein S16 signature. 550538012810 signal recognition particle protein; Provisional; Region: PRK10867 550538012811 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 550538012812 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 550538012813 P loop; other site 550538012814 GTP binding site [chemical binding]; other site 550538012815 Signal peptide binding domain; Region: SRP_SPB; pfam02978 550538012816 HMMPfam hit to PF02978, Signal recognition particle, SRP54 subunit, M-domain, score 7.9e-53 550538012817 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 2.8e-119 550538012818 PS00300 SRP54-type proteins GTP-binding domain signature. 550538012819 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538012820 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012821 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 1.9e-35 550538012822 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 550538012823 8 probable transmembrane helices predicted for SG2656 by TMHMM2.0 at aa 2-24, 34-56, 63-85, 90-109, 129-151, 176-198, 210-227 and 237-254 550538012824 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 7.2e-73 550538012825 hypothetical protein; Provisional; Region: PRK11573 550538012826 Domain of unknown function DUF21; Region: DUF21; pfam01595 550538012827 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 550538012828 Transporter associated domain; Region: CorC_HlyC; smart01091 550538012829 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 1.5e-61 550538012830 3 probable transmembrane helices predicted for SG2657 by TMHMM2.0 at aa 33-55, 65-83 and 95-117 550538012831 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 7.4e-16 550538012832 HMMPfam hit to PF03471, Transporter-associated region, score 2.4e-24 550538012833 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 550538012834 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 550538012835 dimer interface [polypeptide binding]; other site 550538012836 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 550538012837 HMMPfam hit to PF01025, GrpE nucleotide exchange factor, score 3.9e-73 550538012838 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 550538012839 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 550538012840 HMMPfam hit to PF01513, ATP-NAD/AcoX kinase, score 1.1e-102 550538012841 recombination and repair protein; Provisional; Region: PRK10869 550538012842 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 550538012843 Walker A/P-loop; other site 550538012844 ATP binding site [chemical binding]; other site 550538012845 Q-loop/lid; other site 550538012846 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 550538012847 ABC transporter signature motif; other site 550538012848 Walker B; other site 550538012849 D-loop; other site 550538012850 H-loop/switch region; other site 550538012851 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1.9e-10 550538012852 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012853 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 550538012854 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 550538012855 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538012856 HMMPfam hit to PF04355, SmpA/OmlA, score 2e-41 550538012857 PS00018 EF-hand calcium-binding domain. 550538012858 PS00215 Mitochondrial energy transfer proteins signature. 550538012859 hypothetical protein; Validated; Region: PRK01777 550538012860 HMMPfam hit to PF03658, Protein of unknown function UPF0125, score 1e-52 550538012861 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 550538012862 putative coenzyme Q binding site [chemical binding]; other site 550538012863 PS00036 bZIP transcription factors basic domain signature. 550538012864 HMMPfam hit to PF03364, Streptomyces cyclase/dehydrase, score 3.5e-44 550538012865 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 550538012866 SmpB-tmRNA interface; other site 550538012867 HMMPfam hit to PF01668, SmpB protein, score 2.5e-41 550538012868 PS01317 Protein smpB signature. 550538012869 Salmonella pathogenicity island 9: SPI-9 550538012871 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 550538012872 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.8e-26 550538012873 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.3e-15 550538012875 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.9e-16 550538012876 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-50 550538012877 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 550538012878 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538012879 1 probable transmembrane helix predicted for SG2671 by TMHMM2.0 at aa 13-35 550538012880 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.6e-08 550538012881 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538012882 PS00543 HlyD family secretion proteins signature. 550538012883 2 probable transmembrane helices predicted for SG2672 by TMHMM2.0 at aa 19-41 and 61-83 550538012884 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 550538012885 This CDS has been interrupted by the insertion of an IS element 550538012886 HMMPfam hit to PF01797, Transposase IS200-like, score 2.4e-70 550538012887 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 550538012888 DNA-binding interface [nucleotide binding]; DNA binding site 550538012889 IS2 transposase TnpB; Reviewed; Region: PRK09409 550538012890 HTH-like domain; Region: HTH_21; pfam13276 550538012891 Integrase core domain; Region: rve; pfam00665 550538012892 Integrase core domain; Region: rve_3; pfam13683 550538012893 HMMPfam hit to PF00665, Integrase, catalytic core, score 2.9e-34 550538012894 possible site of programmed ribosomal frame shift 550538012895 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.5e-28 550538012896 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 550538012897 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 550538012898 homodimer interface [polypeptide binding]; other site 550538012899 active site 550538012900 TDP-binding site; other site 550538012901 acceptor substrate-binding pocket; other site 550538012902 HMMPfam hit to PF06722, Protein of unknown function DUF1205, score 1.6e-43 550538012903 PS00215 Mitochondrial energy transfer proteins signature. 550538012904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 550538012905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538012906 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 550538012907 Walker A/P-loop; other site 550538012908 ATP binding site [chemical binding]; other site 550538012909 Q-loop/lid; other site 550538012910 ABC transporter signature motif; other site 550538012911 Walker B; other site 550538012912 D-loop; other site 550538012913 H-loop/switch region; other site 550538012914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 550538012915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 550538012916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538012917 Walker A/P-loop; other site 550538012918 ATP binding site [chemical binding]; other site 550538012919 Q-loop/lid; other site 550538012920 ABC transporter signature motif; other site 550538012921 Walker B; other site 550538012922 D-loop; other site 550538012923 H-loop/switch region; other site 550538012924 11 probable transmembrane helices predicted for SG2679 by TMHMM2.0 at aa 27-49, 64-83, 138-160, 165-182, 243-265, 280-302, 649-671, 686-708, 767-786, 790-809 and 871-893 550538012925 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.4e-20 550538012926 HMMPfam hit to PF00005, ABC transporter related, score 4.2e-61 550538012927 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012928 PS00211 ABC transporters family signature. 550538012929 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.5e-32 550538012930 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-51 550538012931 PS00017 ATP/GTP-binding site motif A (P-loop). 550538012933 HMMPfam hit to PF00756, esterase, score 2.8e-75 550538012934 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 550538012935 1 probable transmembrane helix predicted for SG2682 by TMHMM2.0 at aa 13-30 550538012936 outer membrane receptor FepA; Provisional; Region: PRK13528 550538012937 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 550538012938 N-terminal plug; other site 550538012939 ligand-binding site [chemical binding]; other site 550538012940 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 1.6e-32 550538012941 PS01156 TonB-dependent receptor proteins signature 2. 550538012942 PS00449 ATP synthase a subunit signature. 550538012943 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 2.6e-32 550538012944 the sequence has been checked and is believed to be correct 550538012945 HMMPfam hit to PF00805, Pentapeptide repeat, score 1.6e-08 550538012946 HMMPfam hit to PF00805, Pentapeptide repeat, score 5.3e-09 550538012947 HMMPfam hit to PF00805, Pentapeptide repeat, score 6e-08 550538012948 HMMPfam hit to PF00805, Pentapeptide repeat, score 3.5e-06 550538012949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 550538012950 HMMPfam hit to PF04393, Protein of unknown function DUF535, score 6.7e-154 550538012951 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 550538012952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 550538012953 HMMPfam hit to PF07395, Mig-14, score 1.1e-194 550538012954 the sequence has been checked and is believed to be correct 550538012955 HMMPfam hit to PF03824, Nickel/cobalt transporter, high-affinity, score 1.6e-128 550538012956 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 550538012957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 550538012958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 550538012959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538012960 dimer interface [polypeptide binding]; other site 550538012961 phosphorylation site [posttranslational modification] 550538012962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538012963 ATP binding site [chemical binding]; other site 550538012964 Mg2+ binding site [ion binding]; other site 550538012965 G-X-G motif; other site 550538012966 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.4e-28 550538012967 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.2e-08 550538012968 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 9.6e-11 550538012969 2 probable transmembrane helices predicted for SG2689 by TMHMM2.0 at aa 15-37 and 170-192 550538012970 HMMPfam hit to PF08521, Two-component sensor kinase N-terminal, score 5.6e-77 550538012971 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538012972 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 550538012973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538012974 active site 550538012975 phosphorylation site [posttranslational modification] 550538012976 intermolecular recognition site; other site 550538012977 dimerization interface [polypeptide binding]; other site 550538012978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538012979 DNA binding site [nucleotide binding] 550538012980 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.6e-18 550538012981 HMMPfam hit to PF00072, Response regulator receiver, score 5.7e-35 550538012982 PS00217 Sugar transport proteins signature 2. 550538012983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 550538012984 HMMPfam hit to PF03401, Bordetella uptake gene, score 2.9e-08 550538012985 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 550538012986 4 probable transmembrane helices predicted for SG2692 by TMHMM2.0 at aa 7-24, 39-56, 69-91 and 106-128 550538012987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 550538012988 HMMPfam hit to PF01970, Protein of unknown function DUF112, transmembrane, score 4.9e-221 550538012989 12 probable transmembrane helices predicted for SG2693 by TMHMM2.0 at aa 20-42, 47-69, 110-132, 142-164, 171-193, 208-230, 260-282, 321-343, 356-378, 388-410, 415-433 and 470-492 550538012990 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 550538012991 substrate binding pocket [chemical binding]; other site 550538012992 active site 550538012993 iron coordination sites [ion binding]; other site 550538012994 HMMPfam hit to PF08943, Protein of unknown function CsiD, score 2.5e-237 550538012996 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.9e-77 550538012997 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 550538012998 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 550538012999 tetramerization interface [polypeptide binding]; other site 550538013000 NAD(P) binding site [chemical binding]; other site 550538013001 catalytic residues [active] 550538013002 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 7e-244 550538013003 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538013004 PS00070 Aldehyde dehydrogenases cysteine active site. 550538013005 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 550538013006 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 550538013007 inhibitor-cofactor binding pocket; inhibition site 550538013008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538013009 catalytic residue [active] 550538013010 HMMPfam hit to PF00202, Aminotransferase class-III, score 6.6e-174 550538013011 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 550538013012 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 550538013013 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.4e-169 550538013014 12 probable transmembrane helices predicted for SG2699 by TMHMM2.0 at aa 19-41, 46-65, 86-108, 123-145, 152-174, 202-224, 245-267, 287-309, 335-357, 362-381, 401-423 and 427-449 550538013015 PS00218 Amino acid permeases signature. 550538013016 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013017 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 550538013018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538013019 DNA-binding site [nucleotide binding]; DNA binding site 550538013020 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 550538013021 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.6e-14 550538013022 PS00043 Bacterial regulatory proteins, gntR family signature. 550538013023 HMMPfam hit to PF07729, GntR, C-terminal, score 6.3e-10 550538013024 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 550538013025 bacterial OsmY and nodulation domain; Region: BON; smart00749 550538013026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538013027 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.8e-13 550538013028 HMMPfam hit to PF04972, Transport-associated, score 2.3e-10 550538013029 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 550538013030 HMMPfam hit to PF01679, Protein of unknown function UPF0057, score 9.1e-24 550538013031 2 probable transmembrane helices predicted for SG2702 by TMHMM2.0 at aa 2-20 and 25-47 550538013032 PS01309 Uncharacterized protein family UPF0057 signature. 550538013033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538013034 dimerization interface [polypeptide binding]; other site 550538013035 putative DNA binding site [nucleotide binding]; other site 550538013036 Transcriptional regulators [Transcription]; Region: MarR; COG1846 550538013037 putative Zn2+ binding site [ion binding]; other site 550538013038 HMMPfam hit to PF01022, Bacterial regulatory protein, ArsR, score 7.6e-18 550538013039 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 550538013040 active site residue [active] 550538013041 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 550538013042 HMMPfam hit to PF00581, Rhodanese-like, score 2.5e-10 550538013043 2 probable transmembrane helices predicted for SG2704 by TMHMM2.0 at aa 113-135 and 139-161 550538013044 PS00287 Cysteine proteases inhibitors signature. 550538013045 the sequence has been checked and is believed to be correct 550538013046 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 8e-50 550538013047 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 550538013048 HMMPfam hit to PF06610, Protein of unknown function DUF1144, score 2.2e-98 550538013049 4 probable transmembrane helices predicted for SG2706 by TMHMM2.0 at aa 12-34, 44-62, 83-105 and 110-132 550538013050 hypothetical protein; Provisional; Region: PRK10556 550538013051 the sequence has been checked and is believed to be correct 550538013052 HMMPfam hit to PF05957, Protein of unknown function DUF883, ElaB, score 2.6e-43 550538013053 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 550538013054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538013055 DNA-binding site [nucleotide binding]; DNA binding site 550538013056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538013057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538013058 homodimer interface [polypeptide binding]; other site 550538013059 catalytic residue [active] 550538013060 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.4e-06 550538013061 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.5e-23 550538013062 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 550538013063 Uncharacterized conserved protein [Function unknown]; Region: COG2128 550538013064 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase, score 1.6e-22 550538013065 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 550538013066 catalytic residues [active] 550538013067 HMMPfam hit to PF00462, Glutaredoxin, score 6.1e-15 550538013068 PS00190 Cytochrome c family heme-binding site signature. 550538013069 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 550538013070 HMMPfam hit to PF07972, Ribonucleotide reductase Class Ib, NrdI, score 2.8e-73 550538013071 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 550538013072 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 550538013073 Class I ribonucleotide reductase; Region: RNR_I; cd01679 550538013074 active site 550538013075 dimer interface [polypeptide binding]; other site 550538013076 catalytic residues [active] 550538013077 effector binding site; other site 550538013078 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 550538013079 HMMPfam hit to PF08343, Ribonucleotide reductase N-terminal, score 4.2e-43 550538013080 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 4.3e-26 550538013081 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 1.2e-279 550538013082 PS00089 Ribonucleotide reductase large subunit signature. 550538013083 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 550538013084 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 550538013085 dimer interface [polypeptide binding]; other site 550538013086 putative radical transfer pathway; other site 550538013087 diiron center [ion binding]; other site 550538013088 tyrosyl radical; other site 550538013089 HMMPfam hit to PF00268, Ribonucleotide reductase, score 1.1e-131 550538013090 PS00368 Ribonucleotide reductase small subunit signature. 550538013091 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 550538013092 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 550538013093 Walker A/P-loop; other site 550538013094 ATP binding site [chemical binding]; other site 550538013095 Q-loop/lid; other site 550538013096 ABC transporter signature motif; other site 550538013097 Walker B; other site 550538013098 D-loop; other site 550538013099 H-loop/switch region; other site 550538013100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 550538013101 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-67 550538013102 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013103 PS00211 ABC transporters family signature. 550538013104 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 3.2e-11 550538013105 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 550538013106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538013107 dimer interface [polypeptide binding]; other site 550538013108 conserved gate region; other site 550538013109 putative PBP binding loops; other site 550538013110 ABC-ATPase subunit interface; other site 550538013111 6 probable transmembrane helices predicted for SG2717 by TMHMM2.0 at aa 94-116, 120-142, 149-171, 197-219, 272-294 and 298-320 550538013112 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-33 550538013113 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538013114 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 550538013115 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 550538013116 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 1.4e-59 550538013117 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013118 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 550538013119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538013120 12 probable transmembrane helices predicted for SG2719 by TMHMM2.0 at aa 11-33, 48-70, 77-94, 104-126, 133-155, 160-182, 217-239, 249-271, 278-295, 300-322, 335-357 and 362-384 550538013121 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2e-41 550538013122 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013123 transcriptional repressor MprA; Provisional; Region: PRK10870 550538013124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 550538013125 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 7.3e-27 550538013126 PS01117 Bacterial regulatory proteins, marR family signature. 550538013127 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 550538013128 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538013129 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538013130 1 probable transmembrane helix predicted for SG2722 by TMHMM2.0 at aa 23-45 550538013131 HMMPfam hit to PF00529, Secretion protein HlyD, score 4.7e-85 550538013132 the sequence has been checked and is believed to be correct 550538013133 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.7e-57 550538013134 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 550538013135 S-ribosylhomocysteinase; Provisional; Region: PRK02260 550538013136 HMMPfam hit to PF02664, S-ribosylhomocysteinase (LuxS), score 3.6e-114 550538013137 glutamate--cysteine ligase; Provisional; Region: PRK02107 550538013138 HMMPfam hit to PF04262, Glutamate--cysteine ligase, score 8.6e-285 550538013139 Predicted membrane protein [Function unknown]; Region: COG1238 550538013140 4 probable transmembrane helices predicted for SG2727 by TMHMM2.0 at aa 15-37, 42-64, 84-106 and 118-140 550538013141 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 550538013142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538013143 motif II; other site 550538013144 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.4e-28 550538013145 carbon storage regulator; Provisional; Region: PRK01712 550538013146 HMMPfam hit to PF02599, Carbon storage regulator, score 7.2e-35 550538013147 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 550538013148 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 550538013149 motif 1; other site 550538013150 active site 550538013151 motif 2; other site 550538013152 motif 3; other site 550538013153 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 550538013154 DHHA1 domain; Region: DHHA1; pfam02272 550538013155 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 1.7e-22 550538013156 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 1.2e-21 550538013157 HMMPfam hit to PF01411, Alanyl-tRNA synthetase, class IIc, score 0 550538013158 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538013159 recombination regulator RecX; Reviewed; Region: recX; PRK00117 550538013160 HMMPfam hit to PF02631, Regulatory protein RecX, score 1.2e-59 550538013161 recombinase A; Provisional; Region: recA; PRK09354 550538013162 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 550538013163 hexamer interface [polypeptide binding]; other site 550538013164 Walker A motif; other site 550538013165 ATP binding site [chemical binding]; other site 550538013166 Walker B motif; other site 550538013167 HMMPfam hit to PF00154, RecA, score 3.3e-253 550538013168 PS00321 recA signature. 550538013169 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013170 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013171 hypothetical protein; Validated; Region: PRK03661 550538013172 HMMPfam hit to PF02464, CinA, C-terminal, score 1.5e-97 550538013173 Transglycosylase SLT domain; Region: SLT_2; pfam13406 550538013174 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538013175 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538013176 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013177 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 550538013178 HMMPfam hit to PF03608, Phosphotransferase system, enzyme II sorbitol-specific factor, score 2.6e-142 550538013179 3 probable transmembrane helices predicted for SG2735 by TMHMM2.0 at aa 26-48, 69-91 and 134-156 550538013180 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 550538013181 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 550538013182 Nucleoside recognition; Region: Gate; pfam07670 550538013183 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 550538013184 HMMPfam hit to PF03612, Sorbitol phosphotransferase enzyme II, N-terminal, score 1.6e-113 550538013185 PS00107 Protein kinases ATP-binding region signature. 550538013186 4 probable transmembrane helices predicted for SG2736 by TMHMM2.0 at aa 181-203, 218-240, 247-269 and 300-322 550538013187 HMMPfam hit to PF07663, Sorbitol phosphotransferase enzyme II, C-terminal, score 1.6e-55 550538013188 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 550538013189 HMMPfam hit to PF03829, Phosphotransferase system, glucitol/sorbitol-specific IIA component, score 6.1e-69 550538013190 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 550538013191 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 550538013192 putative NAD(P) binding site [chemical binding]; other site 550538013193 active site 550538013194 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.3e-26 550538013195 PS00061 Short-chain dehydrogenases/reductases family signature. 550538013196 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 550538013197 HMMPfam hit to PF06923, Glucitol operon activator, score 2.7e-59 550538013198 1 probable transmembrane helix predicted for SG2739 by TMHMM2.0 at aa 2-24 550538013199 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 550538013200 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 550538013201 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538013202 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 4.4e-25 550538013203 PS00894 Bacterial regulatory proteins, deoR family signature. 550538013204 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.7e-79 550538013205 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 550538013206 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 550538013207 putative active site [active] 550538013208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 550538013209 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.7e-34 550538013210 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.6e-21 550538013211 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 550538013212 GAF domain; Region: GAF; pfam01590 550538013213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538013214 Walker A motif; other site 550538013215 ATP binding site [chemical binding]; other site 550538013216 Walker B motif; other site 550538013217 arginine finger; other site 550538013218 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538013219 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 2.4e-144 550538013220 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538013221 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538013222 HMMPfam hit to PF01590, GAF, score 1.5e-12 550538013223 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 550538013224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 550538013225 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 550538013226 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 550538013227 iron binding site [ion binding]; other site 550538013228 HMMPfam hit to PF00753, Beta-lactamase-like, score 8.4e-30 550538013229 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 2.2e-24 550538013230 HMMPfam hit to PF00301, Rubredoxin-type Fe(Cys)4 protein, score 4.3e-23 550538013231 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 550538013232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538013233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538013234 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5.1e-27 550538013235 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.1e-27 550538013236 Acylphosphatase; Region: Acylphosphatase; pfam00708 550538013237 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 550538013238 HypF finger; Region: zf-HYPF; pfam07503 550538013239 HypF finger; Region: zf-HYPF; pfam07503 550538013240 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 550538013241 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 1.6e-68 550538013242 HMMPfam hit to PF07503, Zinc finger, HypF-type, score 3.1e-15 550538013243 HMMPfam hit to PF07503, Zinc finger, HypF-type, score 1.8e-16 550538013244 HMMPfam hit to PF00708, Acylphosphatase, score 5.1e-07 550538013245 PS00150 Acylphosphatase signature 1. 550538013246 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 550538013247 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 550538013248 PS00190 Cytochrome c family heme-binding site signature. 550538013249 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.5e-08 550538013250 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538013251 1 probable transmembrane helix predicted for SG2747 by TMHMM2.0 at aa 13-35 550538013252 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 550538013253 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 550538013254 nickel binding site [ion binding]; other site 550538013255 HMMPfam hit to PF01750, Peptidase A31, hydrogen uptake protein, score 4.3e-36 550538013256 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 550538013257 HMMPfam hit to PF07450, Formate hydrogenlyase maturation HycH, score 1.4e-102 550538013258 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 550538013259 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 8.2e-53 550538013260 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 550538013261 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 550538013262 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 550538013263 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.1e-08 550538013264 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538013265 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.1e-07 550538013266 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538013267 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 550538013268 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 550538013269 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 550538013270 HMMPfam hit to PF00346, NADH-ubiquinone oxidoreductase, chain 49kDa, score 3e-13 550538013271 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, large subunit, score 1.2e-11 550538013272 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 550538013273 HMMPfam hit to PF00329, NADH dehydrogenase (ubiquinone), 30 kDa subunit, score 9e-15 550538013274 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 550538013275 NADH dehydrogenase; Region: NADHdh; cl00469 550538013276 HMMPfam hit to PF00146, Respiratory-chain NADH dehydrogenase, subunit 1, score 4.4e-06 550538013277 7 probable transmembrane helices predicted for SG2753 by TMHMM2.0 at aa 5-27, 62-84, 94-111, 132-154, 169-188, 252-274 and 289-306 550538013278 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 550538013279 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 550538013280 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 550538013281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 550538013282 15 probable transmembrane helices predicted for SG2754 by TMHMM2.0 at aa 4-26, 31-53, 73-95, 108-125, 129-148, 155-177, 197-219, 231-253, 257-279, 292-311, 326-348, 373-395, 415-437, 457-479 and 499-521 550538013283 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 1e-28 550538013284 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 550538013285 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.5e-07 550538013286 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538013287 PS00190 Cytochrome c family heme-binding site signature. 550538013288 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 550538013289 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 550538013290 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 550538013291 HMMPfam hit to PF01155, Hydrogenase expression/synthesis, HypA, score 3.6e-56 550538013292 PS01249 Hydrogenases expression/synthesis hypA family signature. 550538013293 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 550538013294 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 2.5e-70 550538013295 hydrogenase assembly chaperone; Provisional; Region: PRK10409 550538013296 HMMPfam hit to PF01455, Hydrogenase expression/formation protein (HUPF/HYPC), score 3.9e-45 550538013297 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 550538013298 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 550538013299 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 550538013300 HMMPfam hit to PF01924, Hydrogenase formation HypD protein, score 8.7e-260 550538013301 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 550538013302 dimerization interface [polypeptide binding]; other site 550538013303 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 550538013304 ATP binding site [chemical binding]; other site 550538013305 HMMPfam hit to PF00586, AIR synthase related protein, score 4.7e-40 550538013306 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 1.9e-34 550538013307 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 550538013308 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 550538013309 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 550538013310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538013311 Walker A motif; other site 550538013312 ATP binding site [chemical binding]; other site 550538013313 Walker B motif; other site 550538013314 arginine finger; other site 550538013315 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 550538013316 HMMPfam hit to PF01590, GAF, score 2.8e-17 550538013317 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 5.5e-147 550538013318 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538013319 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538013320 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 2.8e-06 550538013321 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 550538013322 Salmonella Pathogenicity Island 1: SPI-1 550538013323 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 550538013324 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 550538013325 metal binding site [ion binding]; metal-binding site 550538013326 1 probable transmembrane helix predicted for SG2764 by TMHMM2.0 at aa 7-26 550538013327 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 3.5e-123 550538013328 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 550538013329 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 550538013330 HMMPfam hit to PF00005, ABC transporter related, score 9.2e-48 550538013331 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013332 PS00211 ABC transporters family signature. 550538013333 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 550538013334 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538013335 ABC-ATPase subunit interface; other site 550538013336 dimer interface [polypeptide binding]; other site 550538013337 putative PBP binding regions; other site 550538013338 HMMPfam hit to PF00950, ABC-3, score 2.2e-106 550538013339 7 probable transmembrane helices predicted for SG2766 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 121-143, 182-204, 217-239 and 249-271 550538013340 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013341 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 550538013342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 550538013343 ABC-ATPase subunit interface; other site 550538013344 dimer interface [polypeptide binding]; other site 550538013345 putative PBP binding regions; other site 550538013346 HMMPfam hit to PF00950, ABC-3, score 6.4e-105 550538013347 8 probable transmembrane helices predicted for SG2767 by TMHMM2.0 at aa 21-43, 58-80, 93-115, 130-152, 169-191, 196-215, 222-244 and 248-267 550538013348 effector protein YopJ; Provisional; Region: PRK15371 550538013349 HMMPfam hit to PF03421, Serine/Threonine acetyltransferase, YopJ, score 3.6e-89 550538013350 transcriptional activator SprB; Provisional; Region: PRK15320 550538013351 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 550538013352 transcriptional regulator SirC; Provisional; Region: PRK15044 550538013353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538013354 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3e-08 550538013355 PS00041 Bacterial regulatory proteins, araC family signature. 550538013356 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 550538013357 invasion protein OrgB; Provisional; Region: PRK15322 550538013358 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 550538013359 invasion protein OrgA; Provisional; Region: PRK15323 550538013360 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 550538013361 1 probable transmembrane helix predicted for SG2774 by TMHMM2.0 at aa 207-229 550538013362 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 1.5e-81 550538013363 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013364 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 550538013365 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 550538013366 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 550538013367 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 550538013368 1 probable transmembrane helix predicted for SG2777 by TMHMM2.0 at aa 141-163 550538013369 transcriptional regulator HilD; Provisional; Region: PRK15185 550538013370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538013371 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 8.3e-05 550538013372 PS00041 Bacterial regulatory proteins, araC family signature. 550538013373 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7e-12 550538013374 invasion protein regulator; Provisional; Region: PRK12370 550538013375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538013376 DNA binding site [nucleotide binding] 550538013377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 550538013378 binding surface 550538013379 TPR motif; other site 550538013380 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.1e-20 550538013381 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 2.4e-05 550538013382 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 550538013383 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538013384 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538013385 catalytic residue [active] 550538013386 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 8.1e-50 550538013387 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 550538013388 SicP binding; Region: SicP-binding; pfam09119 550538013389 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 550538013390 switch II binding region; other site 550538013391 Rac1 P-loop interaction site [polypeptide binding]; other site 550538013392 GTP binding residues [chemical binding]; other site 550538013393 switch I binding region; other site 550538013394 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 550538013395 active site 550538013396 HMMPfam hit to PF00102, Protein-tyrosine phosphatase, receptor/non-receptor type, score 1.1e-23 550538013397 PS00383 Tyrosine specific protein phosphatases active site. 550538013398 HMMPfam hit to PF03545, Yersinia virulence determinant YopE, C-terminal, score 2.1e-47 550538013399 HMMPfam hit to PF09119, SicP binding, score 3e-57 550538013400 chaperone protein SicP; Provisional; Region: PRK15329 550538013401 HMMPfam hit to PF05932, Tir chaperone, score 1.3e-07 550538013402 putative acyl carrier protein IacP; Validated; Region: PRK08172 550538013403 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 1.4e-05 550538013404 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 550538013405 HMMPfam hit to PF09052, Salmonella invasion protein A, score 0 550538013406 cell invasion protein SipD; Provisional; Region: PRK15330 550538013407 HMMPfam hit to PF06511, Invasion plasmid antigen IpaD, score 3.5e-272 550538013408 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 550538013409 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 550538013410 HMMPfam hit to PF03518, Salmonella/Shigella invasin protein B, score 2.8e-279 550538013411 2 probable transmembrane helices predicted for SG2787 by TMHMM2.0 at aa 320-342 and 408-430 550538013412 chaperone protein SicA; Provisional; Region: PRK15331 550538013413 Tetratricopeptide repeat; Region: TPR_3; pfam07720 550538013414 Tetratricopeptide repeat; Region: TPR_3; pfam07720 550538013415 HMMPfam hit to PF07720, Tetratricopeptide TPR-3, score 1.4e-11 550538013416 HMMPfam hit to PF07720, Tetratricopeptide TPR-3, score 3.5e-13 550538013417 type III secretion system protein SpaS; Validated; Region: PRK08156 550538013418 HMMPfam hit to PF01312, Type III secretion exporter, score 2e-166 550538013419 4 probable transmembrane helices predicted for SG2789 by TMHMM2.0 at aa 29-51, 72-94, 136-153 and 178-200 550538013420 type III secretion system protein SpaR; Provisional; Region: PRK15332 550538013421 HMMPfam hit to PF01311, Type III secretion system inner membrane R protein, score 1.8e-109 550538013422 6 probable transmembrane helices predicted for SG2790 by TMHMM2.0 at aa 10-32, 37-59, 79-101, 128-150, 181-203 and 210-232 550538013423 type III secretion system protein SpaQ; Provisional; Region: PRK15333 550538013424 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 8e-43 550538013425 2 probable transmembrane helices predicted for SG2791 by TMHMM2.0 at aa 12-34 and 49-71 550538013426 PS00888 Cyclic nucleotide-binding domain signature 1. 550538013427 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 550538013428 HMMPfam hit to PF00813, Type III secretion system inner membrane P protein, score 1e-124 550538013429 PS01061 Flagella transport protein fliP family signature 2. 550538013430 3 probable transmembrane helices predicted for SG2792 by TMHMM2.0 at aa 15-37, 50-69 and 161-183 550538013431 PS01060 Flagella transport protein fliP family signature 1. 550538013432 type III secretion system protein SpaO; Validated; Region: PRK08158 550538013433 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 550538013434 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 3.1e-27 550538013435 antigen presentation protein SpaN; Provisional; Region: PRK15334 550538013436 Surface presentation of antigens protein; Region: SPAN; pfam02510 550538013437 HMMPfam hit to PF02510, Salmonella invasion protein InvJ, score 6.9e-284 550538013438 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 550538013439 HMMPfam hit to PF02090, Salmonella surface presentation of antigen M protein, score 8.4e-117 550538013440 ATP synthase SpaL; Validated; Region: PRK08149 550538013441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 550538013442 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 550538013443 Walker A motif; other site 550538013444 ATP binding site [chemical binding]; other site 550538013445 Walker B motif; other site 550538013446 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 2.2e-118 550538013447 PS00152 ATP synthase alpha and beta subunits signature. 550538013448 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013449 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 2.7e-05 550538013450 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 550538013451 HMMPfam hit to PF03519, Invasion protein B, score 2.6e-55 550538013452 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 550538013453 type III secretion system protein InvA; Provisional; Region: PRK15337 550538013454 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 0 550538013455 8 probable transmembrane helices predicted for SG2798 by TMHMM2.0 at aa 13-30, 35-57, 69-91, 106-128, 197-219, 239-261, 274-291 and 296-315 550538013456 PS00994 Bacterial export FHIPEP family signature. 550538013457 type III secretion system regulator InvE; Provisional; Region: PRK15338 550538013458 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 550538013459 HMMPfam hit to PF02523, Salmonella/Shigella invasion protein E, score 4.7e-293 550538013460 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 550538013461 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 550538013462 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 550538013463 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 550538013464 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 8.7e-72 550538013465 PS00875 Bacterial type II secretion system protein D signature. 550538013466 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013467 HMMPfam hit to PF03958, NolW-like, score 1.6e-13 550538013468 HMMPfam hit to PF03958, NolW-like, score 1.8e-10 550538013469 transcriptional regulator InvF; Provisional; Region: PRK15340 550538013470 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.0014 550538013471 PS00041 Bacterial regulatory proteins, araC family signature. 550538013472 InvH outer membrane lipoprotein; Region: InvH; pfam04741 550538013473 HMMPfam hit to PF04741, InvH outer membrane lipoprotein, score 1.4e-120 550538013474 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 550538013477 HMMPfam hit to PF08681, Protein of unknown function DUF1778, score 1e-34 550538013478 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.00047 550538013479 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 550538013480 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 550538013481 active site 550538013482 metal binding site [ion binding]; metal-binding site 550538013483 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.1e-18 550538013484 2 probable transmembrane helices predicted for SG2808 by TMHMM2.0 at aa 27-49 and 59-81 550538013485 2 probable transmembrane helices predicted for SG2809 by TMHMM2.0 at aa 13-35 and 40-62 550538013486 the sequence has been checked and is believed to be correct 550538013487 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 550538013488 MutS domain I; Region: MutS_I; pfam01624 550538013489 MutS domain II; Region: MutS_II; pfam05188 550538013490 MutS domain III; Region: MutS_III; pfam05192 550538013491 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 550538013492 Walker A/P-loop; other site 550538013493 ATP binding site [chemical binding]; other site 550538013494 Q-loop/lid; other site 550538013495 ABC transporter signature motif; other site 550538013496 Walker B; other site 550538013497 D-loop; other site 550538013498 H-loop/switch region; other site 550538013499 HMMPfam hit to PF01624, DNA mismatch repair protein MutS, N-terminal, score 6.2e-73 550538013500 HMMPfam hit to PF05188, MutS II, score 5.5e-50 550538013501 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538013502 HMMPfam hit to PF05192, MutS III, score 3e-99 550538013503 HMMPfam hit to PF05190, MutS IV, score 1.3e-41 550538013504 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 7.1e-175 550538013505 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013506 PS00486 DNA mismatch repair proteins mutS family signature. 550538013507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 550538013508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538013509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 550538013510 putative substrate translocation pore; other site 550538013511 12 probable transmembrane helices predicted for SG2814 by TMHMM2.0 at aa 7-29, 42-64, 69-88, 98-120, 129-151, 161-183, 203-225, 235-257, 270-289, 299-321, 342-361 and 366-388 550538013512 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.7e-46 550538013513 PS00217 Sugar transport proteins signature 2. 550538013514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538013515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538013516 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 550538013517 putative effector binding pocket; other site 550538013518 dimerization interface [polypeptide binding]; other site 550538013519 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.8e-16 550538013520 PS00044 Bacterial regulatory proteins, lysR family signature. 550538013521 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.4e-45 550538013522 GntP family permease; Region: GntP_permease; pfam02447 550538013523 fructuronate transporter; Provisional; Region: PRK10034; cl15264 550538013524 12 probable transmembrane helices predicted for SG2816 by TMHMM2.0 at aa 4-23, 30-48, 58-80, 104-126, 176-198, 241-263, 278-300, 320-337, 357-379, 392-414, 434-456 and 463-485 550538013525 HMMPfam hit to PF02447, Gluconate transporter, score 2.3e-201 550538013526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 550538013527 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 550538013528 putative NAD(P) binding site [chemical binding]; other site 550538013529 active site 550538013530 putative substrate binding site [chemical binding]; other site 550538013531 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 3.7e-19 550538013532 hypothetical protein; Provisional; Region: PRK09989 550538013533 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 6e-52 550538013534 putative aldolase; Validated; Region: PRK08130 550538013535 intersubunit interface [polypeptide binding]; other site 550538013536 active site 550538013537 Zn2+ binding site [ion binding]; other site 550538013538 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 4.9e-65 550538013539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 550538013540 HMMPfam hit to PF07005, Type III effector Hrp-dependent outers, score 3.5e-139 550538013541 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 550538013542 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 550538013543 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 5.3e-58 550538013544 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 550538013545 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538013546 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538013547 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538013548 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 3.1e-18 550538013549 PS00894 Bacterial regulatory proteins, deoR family signature. 550538013550 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.5e-35 550538013551 MarR family; Region: MarR_2; cl17246 550538013552 Transcriptional regulators [Transcription]; Region: MarR; COG1846 550538013553 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 4e-17 550538013554 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 550538013555 Flavoprotein; Region: Flavoprotein; pfam02441 550538013556 HMMPfam hit to PF02441, Flavoprotein, score 2.7e-47 550538013557 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 550538013558 HMMPfam hit to PF01977, Carboxylyase-related, score 8.7e-157 550538013559 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 550538013560 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 550538013561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 550538013562 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 550538013563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 550538013564 DNA binding residues [nucleotide binding] 550538013565 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1.5e-20 550538013566 PS00716 Sigma-70 factors family signature 2. 550538013567 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 1.3e-27 550538013568 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 5.2e-27 550538013569 PS00715 Sigma-70 factors family signature 1. 550538013570 HMMPfam hit to PF00140, RNA polymerase sigma-70 region 1.2, score 3.1e-13 550538013571 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 550538013572 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538013573 Peptidase family M23; Region: Peptidase_M23; pfam01551 550538013574 HMMPfam hit to PF01551, Peptidase M23B, score 3.7e-54 550538013575 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 7.9e-13 550538013576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013577 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 550538013578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538013579 S-adenosylmethionine binding site [chemical binding]; other site 550538013580 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O-methyltransferase, score 2.2e-124 550538013581 PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 550538013582 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538013583 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 550538013584 HMMPfam hit to PF01975, Survival protein SurE, score 3.4e-108 550538013585 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 550538013586 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 550538013587 Permutation of conserved domain; other site 550538013588 active site 550538013589 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 550538013590 HMMPfam hit to PF01142, tRNA pseudouridine synthase D, score 2.1e-169 550538013591 PS01268 Uncharacterized protein family UPF0024 signature. 550538013592 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 550538013593 homotrimer interaction site [polypeptide binding]; other site 550538013594 zinc binding site [ion binding]; other site 550538013595 CDP-binding sites; other site 550538013596 HMMPfam hit to PF02542, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core, score 3.3e-102 550538013597 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 550538013598 substrate binding site; other site 550538013599 dimer interface; other site 550538013600 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 5.7e-142 550538013601 PS01295 Uncharacterized protein family UPF0007 signature. 550538013602 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 550538013603 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 550538013604 HMMPfam hit to PF04977, Septum formation initiator, score 2.3e-35 550538013605 1 probable transmembrane helix predicted for SG2834 by TMHMM2.0 at aa 4-21 550538013606 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 550538013607 3 probable transmembrane helices predicted for SG2835 by TMHMM2.0 at aa 34-56, 63-85 and 95-117 550538013608 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 550538013609 ligand-binding site [chemical binding]; other site 550538013610 HMMPfam hit to PF01583, Adenylylsulphate kinase, C-terminal, score 1.6e-108 550538013611 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013612 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 550538013613 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 550538013614 CysD dimerization site [polypeptide binding]; other site 550538013615 G1 box; other site 550538013616 putative GEF interaction site [polypeptide binding]; other site 550538013617 GTP/Mg2+ binding site [chemical binding]; other site 550538013618 Switch I region; other site 550538013619 G2 box; other site 550538013620 G3 box; other site 550538013621 Switch II region; other site 550538013622 G4 box; other site 550538013623 G5 box; other site 550538013624 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 550538013625 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 550538013626 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.7e-08 550538013627 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 7.1e-71 550538013628 PS00301 GTP-binding elongation factors signature. 550538013629 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013630 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 550538013631 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 550538013632 Active Sites [active] 550538013633 HMMPfam hit to PF01507, Phosphoadenosine phosphosulphate reductase, score 1.3e-143 550538013634 PS00215 Mitochondrial energy transfer proteins signature. 550538013635 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 550538013636 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 550538013637 metal binding site [ion binding]; metal-binding site 550538013638 HMMPfam hit to PF04389, Peptidase M28, score 2.3e-37 550538013639 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 550538013640 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 550538013641 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 550538013642 HMMPfam hit to PF08798, CRISPR-associated protein, CT1974, score 6.4e-99 550538013643 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 550538013644 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 550538013645 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 550538013646 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 550538013647 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 550538013648 the sequence has been checked and is believed to be correct 550538013649 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 550538013650 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 550538013651 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 550538013652 Active Sites [active] 550538013653 HMMPfam hit to PF01507, Phosphoadenosine phosphosulphate reductase, score 7.9e-87 550538013654 sulfite reductase subunit beta; Provisional; Region: PRK13504 550538013655 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 550538013656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 550538013657 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 550538013658 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 2.2e-18 550538013659 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S region, score 2.9e-59 550538013660 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 4.2e-19 550538013661 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 550538013662 Flavodoxin; Region: Flavodoxin_1; pfam00258 550538013663 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 550538013664 FAD binding pocket [chemical binding]; other site 550538013665 FAD binding motif [chemical binding]; other site 550538013666 catalytic residues [active] 550538013667 NAD binding pocket [chemical binding]; other site 550538013668 phosphate binding motif [ion binding]; other site 550538013669 beta-alpha-beta structure motif; other site 550538013670 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 6.1e-35 550538013671 HMMPfam hit to PF00667, FAD-binding, score 1.5e-78 550538013672 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 4.3e-41 550538013673 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 550538013674 active site 550538013675 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase and hypothetical protein, score 4.8e-80 550538013676 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 550538013677 HMMPfam hit to PF00753, Beta-lactamase-like, score 4.4e-16 550538013678 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 550538013679 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 550538013680 HMMPfam hit to PF04055, Radical SAM, score 0.018 550538013681 enolase; Provisional; Region: eno; PRK00077 550538013682 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 550538013683 dimer interface [polypeptide binding]; other site 550538013684 metal binding site [ion binding]; metal-binding site 550538013685 substrate binding pocket [chemical binding]; other site 550538013686 HMMPfam hit to PF00113, Enolase, score 2.5e-190 550538013687 PS00164 Enolase signature. 550538013688 HMMPfam hit to PF03952, Enolase, score 1e-69 550538013689 CTP synthetase; Validated; Region: pyrG; PRK05380 550538013690 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 550538013691 Catalytic site [active] 550538013692 active site 550538013693 UTP binding site [chemical binding]; other site 550538013694 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 550538013695 active site 550538013696 putative oxyanion hole; other site 550538013697 catalytic triad [active] 550538013698 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.5e-80 550538013699 PS00442 Glutamine amidotransferases class-I active site. 550538013700 HMMPfam hit to PF06418, CTP synthase, score 8e-215 550538013701 1 probable transmembrane helix predicted for SG2857 by TMHMM2.0 at aa 7-29 550538013702 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 550538013703 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 550538013704 homodimer interface [polypeptide binding]; other site 550538013705 metal binding site [ion binding]; metal-binding site 550538013706 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 550538013707 homodimer interface [polypeptide binding]; other site 550538013708 active site 550538013709 putative chemical substrate binding site [chemical binding]; other site 550538013710 metal binding site [ion binding]; metal-binding site 550538013711 HMMPfam hit to PF03819, NTP pyrophosphohydrolase MazG, catalytic core, score 8.5e-05 550538013712 HMMPfam hit to PF03819, NTP pyrophosphohydrolase MazG, catalytic core, score 4e-43 550538013713 fimbrial operon ste 550538013714 fimbrial protein SteA; Provisional; Region: PRK15261 550538013715 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 5e-18 550538013716 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013717 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 550538013718 PapC N-terminal domain; Region: PapC_N; pfam13954 550538013719 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 550538013720 PapC C-terminal domain; Region: PapC_C; pfam13953 550538013721 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 4.5e-300 550538013722 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 550538013723 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 550538013724 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538013725 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538013726 1 probable transmembrane helix predicted for SG2861 by TMHMM2.0 at aa 12-29 550538013727 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 2.7e-43 550538013728 PS00635 Gram-negative pili assembly chaperone signature. 550538013729 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 0.00012 550538013730 putative fimbrial protein SteD; Provisional; Region: PRK15275 550538013731 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0013 550538013732 putative fimbrial subunit SteE; Provisional; Region: PRK15276 550538013733 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0069 550538013734 fimbrial protein SteF; Provisional; Region: PRK15260 550538013735 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 5.2e-19 550538013736 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 550538013737 HD domain; Region: HD_4; pfam13328 550538013738 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 550538013739 synthetase active site [active] 550538013740 NTP binding site [chemical binding]; other site 550538013741 metal binding site [ion binding]; metal-binding site 550538013742 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 550538013743 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 550538013744 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.8e-09 550538013745 HMMPfam hit to PF02824, TGS, score 1.7e-30 550538013746 HMMPfam hit to PF04607, RelA/SpoT, score 1.8e-47 550538013747 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 550538013748 TRAM domain; Region: TRAM; pfam01938 550538013749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538013750 S-adenosylmethionine binding site [chemical binding]; other site 550538013751 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 3.4e-10 550538013752 PS01231 RNA methyltransferase trmA family signature 2. 550538013753 PS01230 RNA methyltransferase trmA family signature 1. 550538013754 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 4e-14 550538013755 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 550538013756 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 550538013757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538013758 dimerization interface [polypeptide binding]; other site 550538013759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538013760 dimer interface [polypeptide binding]; other site 550538013761 phosphorylation site [posttranslational modification] 550538013762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538013763 ATP binding site [chemical binding]; other site 550538013764 Mg2+ binding site [ion binding]; other site 550538013765 G-X-G motif; other site 550538013766 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 550538013767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538013768 active site 550538013769 phosphorylation site [posttranslational modification] 550538013770 intermolecular recognition site; other site 550538013771 dimerization interface [polypeptide binding]; other site 550538013772 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 550538013773 putative binding surface; other site 550538013774 active site 550538013775 2 probable transmembrane helices predicted for SG2868 by TMHMM2.0 at aa 10-32 and 177-199 550538013776 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.8e-13 550538013777 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.6e-27 550538013778 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.7e-43 550538013779 HMMPfam hit to PF00072, Response regulator receiver, score 8.2e-46 550538013780 HMMPfam hit to PF01627, Hpt, score 1.6e-17 550538013781 the sequence has been checked and is believed to be correct 550538013782 HMMPfam hit to PF02595, Glycerate kinase, score 1.4e-236 550538013783 the sequence has been checked and is believed to be correct 550538013784 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 4.6e-16 550538013786 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.1e-26 550538013787 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 7.8e-09 550538013788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538013789 D-galactonate transporter; Region: 2A0114; TIGR00893 550538013790 putative substrate translocation pore; other site 550538013791 12 probable transmembrane helices predicted for SG2873 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 152-174, 179-201, 256-278, 293-315, 328-348, 352-374, 387-409 and 414-436 550538013792 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 7.9e-65 550538013793 flavodoxin; Provisional; Region: PRK08105 550538013794 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 9.1e-32 550538013795 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 550538013796 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 550538013797 probable active site [active] 550538013798 HMMPfam hit to PF00849, Pseudouridine synthase, score 2.5e-54 550538013799 PS01129 Rlu family of pseudouridine synthase signature. 550538013800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 550538013801 HMMPfam hit to PF04287, Protein of unknown function DUF446, score 1.5e-54 550538013802 SecY interacting protein Syd; Provisional; Region: PRK04968 550538013803 HMMPfam hit to PF07348, Syd, score 9.4e-119 550538013804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 550538013805 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 550538013806 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 550538013807 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 8.1e-08 550538013808 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 550538013809 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 550538013810 HMMPfam hit to PF03641, Conserved hypothetical protein CHP00730, score 2.4e-56 550538013811 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 550538013812 serine transporter; Region: stp; TIGR00814 550538013813 11 probable transmembrane helices predicted for SG2880 by TMHMM2.0 at aa 24-41, 45-67, 103-125, 140-157, 164-186, 206-228, 249-271, 300-322, 351-373, 377-394 and 406-428 550538013814 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 550538013815 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 550538013816 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 550538013817 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 4.6e-106 550538013818 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.1e-202 550538013819 flap endonuclease-like protein; Provisional; Region: PRK09482 550538013820 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 550538013821 active site 550538013822 metal binding site 1 [ion binding]; metal-binding site 550538013823 putative 5' ssDNA interaction site; other site 550538013824 metal binding site 3; metal-binding site 550538013825 metal binding site 2 [ion binding]; metal-binding site 550538013826 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 550538013827 putative DNA binding site [nucleotide binding]; other site 550538013828 putative metal binding site [ion binding]; other site 550538013829 HMMPfam hit to PF02739, 5'-3' exonuclease, score 8.5e-21 550538013830 HMMPfam hit to PF01367, 5'-3' exonuclease, score 4.9e-27 550538013831 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 550538013832 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 550538013833 dimer interface [polypeptide binding]; other site 550538013834 active site 550538013835 metal binding site [ion binding]; metal-binding site 550538013836 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 4.3e-203 550538013837 PS00060 Iron-containing alcohol dehydrogenases signature 2. 550538013838 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538013839 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 550538013840 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 550538013841 intersubunit interface [polypeptide binding]; other site 550538013842 active site 550538013843 Zn2+ binding site [ion binding]; other site 550538013844 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 1.6e-75 550538013845 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 550538013846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538013847 putative substrate translocation pore; other site 550538013848 12 probable transmembrane helices predicted for SG2885 by TMHMM2.0 at aa 24-41, 61-83, 88-110, 120-142, 155-177, 212-234, 260-282, 292-314, 327-346, 351-373, 382-404 and 414-431 550538013849 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.4e-19 550538013850 L-fucose isomerase; Provisional; Region: fucI; PRK10991 550538013851 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 550538013852 hexamer (dimer of trimers) interface [polypeptide binding]; other site 550538013853 trimer interface [polypeptide binding]; other site 550538013854 substrate binding site [chemical binding]; other site 550538013855 Mn binding site [ion binding]; other site 550538013856 HMMPfam hit to PF07881, L-fucose isomerase, N-terminal-1, score 1.7e-128 550538013857 HMMPfam hit to PF07882, L-fucose isomerase, N-terminal-2, score 2.9e-123 550538013858 HMMPfam hit to PF02952, L-fucose isomerase-like, C-terminal, score 1.8e-116 550538013859 L-fuculokinase; Provisional; Region: PRK10331 550538013860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 550538013861 nucleotide binding site [chemical binding]; other site 550538013862 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1e-111 550538013863 PS00933 FGGY family of carbohydrate kinases signature 1. 550538013864 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 3.8e-77 550538013865 PS00445 FGGY family of carbohydrate kinases signature 2. 550538013866 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 550538013867 HMMPfam hit to PF05025, RbsD or FucU transport, score 1.3e-57 550538013868 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 550538013869 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 550538013870 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538013871 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.1e-21 550538013872 PS00894 Bacterial regulatory proteins, deoR family signature. 550538013873 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 7.5e-71 550538013874 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 550538013875 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 550538013876 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 5.1e-07 550538013877 hypothetical protein; Provisional; Region: PRK10873 550538013878 4 probable transmembrane helices predicted for SG2891 by TMHMM2.0 at aa 5-27, 37-59, 66-88 and 98-120 550538013879 HMMPfam hit to PF04241, Protein of unknown function DUF423, score 3.4e-54 550538013880 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 550538013881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538013882 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 550538013883 dimerization interface [polypeptide binding]; other site 550538013884 substrate binding pocket [chemical binding]; other site 550538013885 HMMPfam hit to PF03466, LysR, substrate-binding, score 3e-47 550538013886 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.5e-22 550538013887 PS00044 Bacterial regulatory proteins, lysR family signature. 550538013888 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 550538013889 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 1.1e-44 550538013890 1 probable transmembrane helix predicted for SG2893 by TMHMM2.0 at aa 5-27 550538013891 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013892 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 550538013893 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 550538013894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538013895 catalytic residue [active] 550538013896 HMMPfam hit to PF00266, Aminotransferase, class V, score 9.2e-194 550538013897 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 550538013898 CsdA-binding activator; Provisional; Region: PRK15019 550538013899 HMMPfam hit to PF02657, Fe-S metabolism associated SufE, score 3.3e-63 550538013900 Predicted permeases [General function prediction only]; Region: RarD; COG2962 550538013901 8 probable transmembrane helices predicted for SG2896 by TMHMM2.0 at aa 7-29, 34-56, 72-93, 97-119, 124-146, 174-196, 208-230 and 262-284 550538013902 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.9e-05 550538013903 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 550538013904 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 550538013905 putative ATP binding site [chemical binding]; other site 550538013906 putative substrate interface [chemical binding]; other site 550538013907 1 probable transmembrane helix predicted for SG2897 by TMHMM2.0 at aa 235-257 550538013908 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 1.5e-54 550538013909 murein transglycosylase A; Provisional; Region: mltA; PRK11162 550538013910 murein hydrolase B; Provisional; Region: PRK10760; cl17906 550538013911 MltA specific insert domain; Region: MltA; pfam03562 550538013912 3D domain; Region: 3D; pfam06725 550538013913 HMMPfam hit to PF06725, 3D, score 1.2e-35 550538013914 HMMPfam hit to PF03562, MltA, score 3.1e-77 550538013915 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538013916 AMIN domain; Region: AMIN; pfam11741 550538013917 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 550538013918 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 550538013919 active site 550538013920 metal binding site [ion binding]; metal-binding site 550538013921 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 2e-108 550538013922 N-acetylglutamate synthase; Validated; Region: PRK05279 550538013923 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 550538013924 putative feedback inhibition sensing region; other site 550538013925 putative nucleotide binding site [chemical binding]; other site 550538013926 putative substrate binding site [chemical binding]; other site 550538013927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538013928 Coenzyme A binding pocket [chemical binding]; other site 550538013929 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 4.5e-36 550538013930 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.1e-10 550538013931 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 550538013932 AAA domain; Region: AAA_30; pfam13604 550538013933 Family description; Region: UvrD_C_2; pfam13538 550538013934 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013935 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 550538013936 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 1.3e-167 550538013937 PS00017 ATP/GTP-binding site motif A (P-loop). 550538013938 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538013939 protease3; Provisional; Region: PRK15101 550538013940 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 550538013941 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 550538013942 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 550538013943 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 5.4e-19 550538013944 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.1e-26 550538013945 HMMPfam hit to PF00675, Peptidase M16, N-terminal, score 1.4e-54 550538013946 PS00143 Insulinase family, zinc-binding region signature. 550538013947 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 550538013948 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 550538013949 HMMPfam hit to PF04257, Exodeoxyribonuclease V, RecC subunit, score 0 550538013950 hypothetical protein; Provisional; Region: PRK10332 550538013951 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 550538013952 1 probable transmembrane helix predicted for SG2905 by TMHMM2.0 at aa 15-37 550538013953 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 0.0023 550538013954 PS00409 Prokaryotic N-terminal methylation site. 550538013955 hypothetical protein; Provisional; Region: PRK11521 550538013956 PS00294 Prenyl group binding site (CAAX box). 550538013957 1 probable transmembrane helix predicted for SG2906 by TMHMM2.0 at aa 10-27 550538013958 hypothetical protein; Provisional; Region: PRK10557 550538013959 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 550538013960 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 0.0031 550538013961 PS00409 Prokaryotic N-terminal methylation site. 550538013962 1 probable transmembrane helix predicted for SG2907 by TMHMM2.0 at aa 7-26 550538013963 hypothetical protein; Provisional; Region: PRK10506 550538013964 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 550538013965 1 probable transmembrane helix predicted for SG2908 by TMHMM2.0 at aa 7-29 550538013966 PS00409 Prokaryotic N-terminal methylation site. 550538013967 thymidylate synthase; Reviewed; Region: thyA; PRK01827 550538013968 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 550538013969 dimerization interface [polypeptide binding]; other site 550538013970 active site 550538013971 HMMPfam hit to PF00303, Thymidylate synthase, C-terminal, score 2e-151 550538013972 PS00091 Thymidylate synthase active site. 550538013973 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 550538013974 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 1.4e-144 550538013975 5 probable transmembrane helices predicted for SG2910 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 223-245 and 260-282 550538013976 PS01311 Prolipoprotein diacylglyceryl transferase signature. 550538013977 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 550538013978 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 550538013979 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 550538013980 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 550538013981 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 550538013982 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 6.1e-160 550538013983 PS00742 PEP-utilizing enzymes signature 2. 550538013984 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538013985 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 4.7e-23 550538013986 PS00370 PEP-utilizing enzymes phosphorylation site signature. 550538013987 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 1.3e-43 550538013988 HMMPfam hit to PF01590, GAF, score 1.1e-26 550538013989 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 550538013990 putative active site [active] 550538013991 Ap4A binding site [chemical binding]; other site 550538013992 nudix motif; other site 550538013993 putative metal binding site [ion binding]; other site 550538013994 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 7.7e-31 550538013995 PS00893 mutT domain signature. 550538013996 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 550538013997 putative DNA-binding cleft [nucleotide binding]; other site 550538013998 putative DNA clevage site; other site 550538013999 molecular lever; other site 550538014000 HMMPfam hit to PF02976, DNA mismatch repair enzyme MutH, score 2e-58 550538014001 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 550538014002 HMMPfam hit to PF03741, Integral membrane protein TerC, score 4.9e-46 550538014003 7 probable transmembrane helices predicted for SG2915 by TMHMM2.0 at aa 15-37, 50-69, 84-101, 122-139, 154-176, 183-202 and 212-230 550538014004 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 550538014005 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 7.5e-48 550538014006 1 probable transmembrane helix predicted for SG2916 by TMHMM2.0 at aa 4-26 550538014007 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014008 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538014009 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538014010 active site 550538014011 catalytic tetrad [active] 550538014012 HMMPfam hit to PF00248, Aldo/keto reductase, score 6.5e-48 550538014013 lysophospholipid transporter LplT; Provisional; Region: PRK11195 550538014014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538014015 10 probable transmembrane helices predicted for SG2918 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 162-184, 220-242, 257-279, 286-305, 309-331, 344-366 and 371-393 550538014016 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 6e-11 550538014017 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 550538014018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 550538014019 putative acyl-acceptor binding pocket; other site 550538014020 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 550538014021 acyl-activating enzyme (AAE) consensus motif; other site 550538014022 putative AMP binding site [chemical binding]; other site 550538014023 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 9.6e-78 550538014024 PS00455 AMP-binding domain signature. 550538014025 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 3.6e-32 550538014026 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 550538014027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538014028 DNA binding site [nucleotide binding] 550538014029 domain linker motif; other site 550538014030 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 550538014031 dimerization interface (closed form) [polypeptide binding]; other site 550538014032 ligand binding site [chemical binding]; other site 550538014033 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4.4e-15 550538014034 PS00356 Bacterial regulatory proteins, lacI family signature. 550538014035 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.2e-19 550538014036 Transcriptional regulators [Transcription]; Region: PurR; COG1609 550538014037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538014038 DNA binding site [nucleotide binding] 550538014039 domain linker motif; other site 550538014040 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 550538014041 dimerization interface (closed form) [polypeptide binding]; other site 550538014042 ligand binding site [chemical binding]; other site 550538014043 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 2.3e-11 550538014044 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.1e-23 550538014045 diaminopimelate decarboxylase; Provisional; Region: PRK11165 550538014046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 550538014047 active site 550538014048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538014049 substrate binding site [chemical binding]; other site 550538014050 catalytic residues [active] 550538014051 dimer interface [polypeptide binding]; other site 550538014052 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 5.4e-35 550538014053 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 2.4e-89 550538014054 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 550538014055 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 550538014056 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 550538014057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538014058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538014059 dimerization interface [polypeptide binding]; other site 550538014060 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.6e-18 550538014061 PS00044 Bacterial regulatory proteins, lysR family signature. 550538014062 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.8e-48 550538014063 putative racemase; Provisional; Region: PRK10200 550538014064 aspartate racemase; Region: asp_race; TIGR00035 550538014065 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 4.9e-58 550538014066 PS00924 Aspartate and glutamate racemases signature 2. 550538014067 PS00923 Aspartate and glutamate racemases signature 1. 550538014068 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 550538014069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538014070 putative substrate translocation pore; other site 550538014071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538014072 HMMPfam hit to PF00083, General substrate transporter, score 1.9e-173 550538014073 12 probable transmembrane helices predicted for SG2925 by TMHMM2.0 at aa 24-46, 61-83, 90-112, 116-138, 150-167, 177-199, 259-281, 296-318, 325-347, 362-384, 397-419 and 424-446 550538014074 PS00216 Sugar transport proteins signature 1. 550538014075 PS00217 Sugar transport proteins signature 2. 550538014076 the sequence has been checked and is believed to be correct 550538014077 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.2e-25 550538014078 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 550538014079 HMMPfam hit to PF04962, 5-keto 4-deoxyuronate isomerase, score 3.6e-205 550538014080 putative acyltransferase; Provisional; Region: PRK05790 550538014081 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 550538014082 dimer interface [polypeptide binding]; other site 550538014083 active site 550538014084 HMMPfam hit to PF02803, Thiolase, score 1.4e-92 550538014085 PS00099 Thiolases active site. 550538014086 PS00737 Thiolases signature 2. 550538014087 HMMPfam hit to PF00108, Thiolase, score 2.7e-157 550538014088 PS00098 Thiolases acyl-enzyme intermediate signature. 550538014089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538014090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538014091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538014092 dimerization interface [polypeptide binding]; other site 550538014093 HMMPfam hit to PF03466, LysR, substrate-binding, score 1e-20 550538014094 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.4e-16 550538014096 HMMPfam hit to PF05232, Transmembrane pair, bacterial, score 3.9e-16 550538014097 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 550538014098 1 probable transmembrane helix predicted for SG2931 by TMHMM2.0 at aa 9-31 550538014099 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 550538014100 HMMPfam hit to PF07313, Protein of unknown function DUF1460, score 1.6e-152 550538014101 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 550538014102 Peptidase family M23; Region: Peptidase_M23; pfam01551 550538014103 HMMPfam hit to PF01551, Peptidase M23B, score 1.3e-52 550538014104 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 1.1e-19 550538014105 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014106 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 550538014107 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 550538014108 active site 550538014109 metal binding site [ion binding]; metal-binding site 550538014110 nudix motif; other site 550538014111 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 3.6e-17 550538014112 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 550538014113 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 550538014114 dimer interface [polypeptide binding]; other site 550538014115 putative anticodon binding site; other site 550538014116 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 550538014117 motif 1; other site 550538014118 active site 550538014119 motif 2; other site 550538014120 motif 3; other site 550538014121 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 2.1e-133 550538014122 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538014123 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538014124 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.6e-20 550538014125 This domain is found in peptide chain release factors; Region: PCRF; smart00937 550538014126 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 550538014127 RF-1 domain; Region: RF-1; pfam00472 550538014128 HMMPfam hit to PF00472, Class I peptide chain release factor, score 4.4e-74 550538014129 PS00745 Prokaryotic-type class I peptide chain release factors signature. 550538014130 HMMPfam hit to PF03462, PCRF, score 8.2e-63 550538014131 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 550538014132 DHH family; Region: DHH; pfam01368 550538014133 DHHA1 domain; Region: DHHA1; pfam02272 550538014134 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 2.4e-17 550538014135 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 5.6e-53 550538014136 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 550538014137 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 550538014138 dimerization domain [polypeptide binding]; other site 550538014139 dimer interface [polypeptide binding]; other site 550538014140 catalytic residues [active] 550538014141 PS00194 Thioredoxin family active site. 550538014142 PS00190 Cytochrome c family heme-binding site signature. 550538014143 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 550538014144 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 550538014145 active site 550538014146 Int/Topo IB signature motif; other site 550538014147 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 6.7e-74 550538014148 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 3e-31 550538014149 flavodoxin FldB; Provisional; Region: PRK12359 550538014150 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 3.4e-41 550538014151 PS00201 Flavodoxin signature. 550538014152 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 550538014153 HMMPfam hit to PF07254, Protein of unknown function DUF1434, score 6.7e-92 550538014154 1 probable transmembrane helix predicted for SG2941 by TMHMM2.0 at aa 20-51 550538014155 hypothetical protein; Provisional; Region: PRK10878 550538014156 HMMPfam hit to PF03937, Protein of unknown function DUF339, score 5.3e-43 550538014157 putative global regulator; Reviewed; Region: PRK09559 550538014158 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 550538014159 hemolysin; Provisional; Region: PRK15087 550538014160 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 550538014161 7 probable transmembrane helices predicted for SG2944 by TMHMM2.0 at aa 20-42, 46-68, 89-107, 112-134, 139-161, 165-187 and 194-216 550538014162 HMMPfam hit to PF03006, Hly-III related proteins, score 7.7e-65 550538014163 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 550538014164 HMMPfam hit to PF06164, Uncharacterised conserved protein UCP029143, score 2.5e-73 550538014165 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 550538014166 beta-galactosidase; Region: BGL; TIGR03356 550538014167 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 8.7e-150 550538014168 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 550538014169 PS00572 Glycosyl hydrolases family 1 active site. 550538014170 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 550538014171 glycine dehydrogenase; Provisional; Region: PRK05367 550538014172 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 550538014173 tetramer interface [polypeptide binding]; other site 550538014174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538014175 catalytic residue [active] 550538014176 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 550538014177 tetramer interface [polypeptide binding]; other site 550538014178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538014179 catalytic residue [active] 550538014180 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 2.3e-292 550538014181 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 550538014182 lipoyl attachment site [posttranslational modification]; other site 550538014183 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 8.8e-77 550538014184 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 550538014185 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 550538014186 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 550538014187 HMMPfam hit to PF08669, Glycine cleavage T-protein, C-terminal barrel, score 4.7e-36 550538014188 HMMPfam hit to PF01571, Glycine cleavage T protein (aminomethyl transferase), score 2.2e-109 550538014189 oxidoreductase; Provisional; Region: PRK08013 550538014190 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 550538014191 PS01304 ubiH/COQ6 monooxygenase family signature. 550538014192 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.2e-07 550538014193 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014194 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 550538014195 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 550538014196 PS01304 ubiH/COQ6 monooxygenase family signature. 550538014197 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 8.1e-05 550538014198 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 7.6e-05 550538014199 proline aminopeptidase P II; Provisional; Region: PRK10879 550538014200 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 550538014201 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 550538014202 active site 550538014203 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 6.4e-118 550538014204 PS00491 Aminopeptidase P and proline dipeptidase signature. 550538014205 HMMPfam hit to PF05195, Peptidase M24B, X-Pro dipeptidase/aminopeptidase P N-terminal, score 8.1e-28 550538014206 hypothetical protein; Reviewed; Region: PRK01736 550538014207 HMMPfam hit to PF03695, Protein of unknown function UPF0149, score 5e-119 550538014208 Z-ring-associated protein; Provisional; Region: PRK10972 550538014209 HMMPfam hit to PF05164, Protein of unknown function DUF710, score 4.4e-38 550538014210 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 550538014211 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 550538014212 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 9.5e-35 550538014213 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 550538014214 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 550538014215 ligand binding site [chemical binding]; other site 550538014216 NAD binding site [chemical binding]; other site 550538014217 tetramer interface [polypeptide binding]; other site 550538014218 catalytic site [active] 550538014219 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 550538014220 L-serine binding site [chemical binding]; other site 550538014221 ACT domain interface; other site 550538014222 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.3e-07 550538014223 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 1.1e-35 550538014224 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 2.7e-67 550538014225 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 550538014226 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 550538014227 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 550538014228 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 550538014229 tetramer (dimer of dimers) interface [polypeptide binding]; other site 550538014230 active site 550538014231 dimer interface [polypeptide binding]; other site 550538014232 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase, score 3.8e-97 550538014233 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 550538014234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538014235 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 550538014236 putative dimerization interface [polypeptide binding]; other site 550538014237 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4e-18 550538014238 PS00044 Bacterial regulatory proteins, lysR family signature. 550538014239 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.8e-06 550538014240 Uncharacterized conserved protein [Function unknown]; Region: COG2968 550538014241 oxidative stress defense protein; Provisional; Region: PRK11087 550538014242 HMMPfam hit to PF04402, Protein of unknown function DUF541, score 1.9e-83 550538014243 arginine exporter protein; Provisional; Region: PRK09304 550538014244 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 3e-73 550538014245 6 probable transmembrane helices predicted for SG2961 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 111-133, 148-170 and 182-199 550538014246 mechanosensitive channel MscS; Provisional; Region: PRK10334 550538014247 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538014248 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 3.1e-83 550538014249 PS01246 Uncharacterized protein family UPF0003 signature. 550538014250 3 probable transmembrane helices predicted for SG2962 by TMHMM2.0 at aa 26-48, 68-90 and 105-127 550538014251 HMMPfam hit to PF05552, Conserved TM helix, score 3.6e-14 550538014252 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 550538014253 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 550538014254 active site 550538014255 intersubunit interface [polypeptide binding]; other site 550538014256 zinc binding site [ion binding]; other site 550538014257 Na+ binding site [ion binding]; other site 550538014258 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 2.1e-211 550538014259 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 550538014260 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 550538014261 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 550538014262 Phosphoglycerate kinase; Region: PGK; pfam00162 550538014263 substrate binding site [chemical binding]; other site 550538014264 hinge regions; other site 550538014265 ADP binding site [chemical binding]; other site 550538014266 catalytic site [active] 550538014267 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 1e-134 550538014268 PS00111 Phosphoglycerate kinase signature. 550538014269 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 550538014270 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 550538014271 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 550538014272 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 1.4e-75 550538014273 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 550538014274 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 3.4e-83 550538014275 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 550538014276 trimer interface [polypeptide binding]; other site 550538014277 putative Zn binding site [ion binding]; other site 550538014278 HMMPfam hit to PF03479, Protein of unknown function DUF296, score 1.9e-15 550538014279 5 probable transmembrane helices predicted for SG2967 by TMHMM2.0 at aa 10-29, 42-64, 74-96, 103-125 and 152-174 550538014280 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 550538014281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014282 4 probable transmembrane helices predicted for SG2968 by TMHMM2.0 at aa 10-29, 50-72, 82-104 and 215-234 550538014283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 550538014284 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 550538014285 Walker A/P-loop; other site 550538014286 ATP binding site [chemical binding]; other site 550538014287 Q-loop/lid; other site 550538014288 ABC transporter signature motif; other site 550538014289 Walker B; other site 550538014290 D-loop; other site 550538014291 H-loop/switch region; other site 550538014292 HMMPfam hit to PF00005, ABC transporter related, score 2.7e-21 550538014293 PS00017 ATP/GTP-binding site motif A (P-loop). 550538014294 PS00017 ATP/GTP-binding site motif A (P-loop). 550538014295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 550538014296 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 550538014297 Walker A/P-loop; other site 550538014298 ATP binding site [chemical binding]; other site 550538014299 Q-loop/lid; other site 550538014300 ABC transporter signature motif; other site 550538014301 Walker B; other site 550538014302 D-loop; other site 550538014303 H-loop/switch region; other site 550538014304 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-32 550538014305 PS00017 ATP/GTP-binding site motif A (P-loop). 550538014306 transketolase; Reviewed; Region: PRK12753 550538014307 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 550538014308 TPP-binding site [chemical binding]; other site 550538014309 dimer interface [polypeptide binding]; other site 550538014310 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 550538014311 PYR/PP interface [polypeptide binding]; other site 550538014312 dimer interface [polypeptide binding]; other site 550538014313 TPP binding site [chemical binding]; other site 550538014314 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 550538014315 HMMPfam hit to PF02780, Transketolase, C-terminal, score 2e-15 550538014316 HMMPfam hit to PF02779, Transketolase, central region, score 1.6e-68 550538014317 PS00802 Transketolase signature 2. 550538014318 HMMPfam hit to PF00456, Transketolase, N-terminal, score 1.4e-257 550538014319 PS00801 Transketolase signature 1. 550538014320 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 550538014321 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014322 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 2.3e-27 550538014323 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 550538014324 agmatinase; Region: agmatinase; TIGR01230 550538014325 oligomer interface [polypeptide binding]; other site 550538014326 putative active site [active] 550538014327 Mn binding site [ion binding]; other site 550538014328 HMMPfam hit to PF00491, Ureohydrolase, score 9.9e-137 550538014329 PS01053 Arginase family signature 3. 550538014330 PS00148 Arginase family signature 2. 550538014331 PS00147 Arginase family signature 1. 550538014332 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 550538014333 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 2.6e-11 550538014334 1 probable transmembrane helix predicted for SG2974 by TMHMM2.0 at aa 20-42 550538014335 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 550538014336 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 4.5e-32 550538014337 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 550538014338 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 1e-116 550538014339 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 550538014340 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 550538014341 putative NAD(P) binding site [chemical binding]; other site 550538014342 catalytic Zn binding site [ion binding]; other site 550538014343 structural Zn binding site [ion binding]; other site 550538014344 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.1e-26 550538014345 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 2.5e-51 550538014346 PS00017 ATP/GTP-binding site motif A (P-loop). 550538014347 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538014348 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 550538014349 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 550538014350 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 550538014351 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 2.5e-89 550538014352 PS00974 Mannitol dehydrogenases signature. 550538014353 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 1.3e-62 550538014354 Transcriptional regulators [Transcription]; Region: FadR; COG2186 550538014355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538014356 DNA-binding site [nucleotide binding]; DNA binding site 550538014357 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 550538014358 HMMPfam hit to PF07729, GntR, C-terminal, score 3.5e-34 550538014359 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.5e-24 550538014360 PS00043 Bacterial regulatory proteins, gntR family signature. 550538014361 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 550538014362 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014363 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 550538014364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 550538014365 dimer interface [polypeptide binding]; other site 550538014366 active site 550538014367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538014368 catalytic residues [active] 550538014369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 550538014370 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 2.9e-41 550538014371 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 5.3e-119 550538014372 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 550538014373 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 550538014374 Virulence promoting factor; Region: YqgB; pfam11036 550538014375 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 550538014376 2 probable transmembrane helices predicted for SG2983 by TMHMM2.0 at aa 21-43 and 63-77 550538014377 S-adenosylmethionine synthetase; Validated; Region: PRK05250 550538014378 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 550538014379 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 550538014380 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 550538014381 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, score 3.7e-63 550538014382 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, score 3.3e-84 550538014383 PS00376 S-adenosylmethionine synthetase signature 1. 550538014384 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, score 4e-98 550538014385 PS00377 S-adenosylmethionine synthetase signature 2. 550538014386 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 550538014387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538014388 putative substrate translocation pore; other site 550538014389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538014390 12 probable transmembrane helices predicted for SG2985 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130, 142-159, 169-191, 252-274, 289-311, 318-340, 350-372, 385-407 and 417-436 550538014391 HMMPfam hit to PF00083, General substrate transporter, score 3.5e-185 550538014392 PS00217 Sugar transport proteins signature 2. 550538014393 PS00216 Sugar transport proteins signature 1. 550538014394 hypothetical protein; Provisional; Region: PRK04860 550538014395 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 550538014396 HMMPfam hit to PF03926, Protein of unknown function DUF335, SprT, score 2.8e-83 550538014397 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538014398 DNA-specific endonuclease I; Provisional; Region: PRK15137 550538014399 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 550538014400 HMMPfam hit to PF04231, Endonuclease I, score 1.5e-130 550538014401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 550538014402 RNA methyltransferase, RsmE family; Region: TIGR00046 550538014403 HMMPfam hit to PF04452, Protein of unknown function DUF558, methyltransferase predicted, score 8.3e-103 550538014404 PS00215 Mitochondrial energy transfer proteins signature. 550538014405 glutathione synthetase; Provisional; Region: PRK05246 550538014406 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 550538014407 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 550538014408 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-terminal, score 3.6e-73 550538014409 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-binding, score 3.9e-129 550538014410 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538014411 hypothetical protein; Validated; Region: PRK00228 550538014412 HMMPfam hit to PF02622, Protein of unknown function DUF179, score 1.1e-104 550538014413 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 550538014414 HMMPfam hit to PF03652, Resolvase, holliday junction-type, YqgF-like, score 3.1e-72 550538014415 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 550538014416 Transcriptional regulator [Transcription]; Region: IclR; COG1414 550538014417 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 3.7e-05 550538014418 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 550538014419 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 550538014420 Walker A motif; other site 550538014421 ATP binding site [chemical binding]; other site 550538014422 Walker B motif; other site 550538014423 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 2.2e-17 550538014424 PS00662 Bacterial type II secretion system protein E signature. 550538014425 PS00017 ATP/GTP-binding site motif A (P-loop). 550538014426 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 550538014427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538014428 catalytic residue [active] 550538014429 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.3e-31 550538014430 PS01211 Uncharacterized protein family UPF0001 signature. 550538014431 YGGT family; Region: YGGT; pfam02325 550538014432 YGGT family; Region: YGGT; pfam02325 550538014433 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 3e-31 550538014434 4 probable transmembrane helices predicted for SG2995 by TMHMM2.0 at aa 5-24, 63-85, 89-111 and 153-175 550538014435 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 1.7e-30 550538014436 hypothetical protein; Validated; Region: PRK05090 550538014437 HMMPfam hit to PF02594, Protein of unknown function DUF167, score 9.4e-37 550538014438 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 550538014439 active site 550538014440 dimerization interface [polypeptide binding]; other site 550538014441 HMMPfam hit to PF01725, Ham1-like protein, score 3.2e-113 550538014442 HemN family oxidoreductase; Provisional; Region: PRK05660 550538014443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538014444 FeS/SAM binding site; other site 550538014445 HemN C-terminal domain; Region: HemN_C; pfam06969 550538014446 HMMPfam hit to PF04055, Radical SAM, score 7.1e-28 550538014447 HMMPfam hit to PF06969, HemN, C-terminal, score 4.6e-21 550538014448 the sequence has been checked and is believed to be correct 550538014449 HMMPfam hit to PF06717, Protein of unknown function DUF1202, score 2e-268 550538014450 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 550538014451 homodimer interface [polypeptide binding]; other site 550538014452 active site 550538014453 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 9.5e-167 550538014454 PS00917 Asparaginase / glutaminase active site signature 2. 550538014455 PS00144 Asparaginase / glutaminase active site signature 1. 550538014456 1 probable transmembrane helix predicted for SG3000 by TMHMM2.0 at aa 7-29 550538014457 hypothetical protein; Provisional; Region: PRK10626 550538014458 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 550538014459 hypothetical protein; Provisional; Region: PRK11702 550538014460 HMMPfam hit to PF04320, Protein of unknown function DUF469, score 1.9e-84 550538014461 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 550538014462 HMMPfam hit to PF02390, methyltransferase, score 3.2e-100 550538014463 adenine DNA glycosylase; Provisional; Region: PRK10880 550538014464 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 550538014465 minor groove reading motif; other site 550538014466 helix-hairpin-helix signature motif; other site 550538014467 substrate binding pocket [chemical binding]; other site 550538014468 active site 550538014469 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 550538014470 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 550538014471 DNA binding and oxoG recognition site [nucleotide binding] 550538014472 HMMPfam hit to PF00730, HhH-GPD, score 6.9e-22 550538014473 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1e-07 550538014474 PS01155 Endonuclease III family signature. 550538014475 PS00764 Endonuclease III iron-sulfur binding region signature. 550538014476 oxidative damage protection protein; Provisional; Region: PRK05408 550538014477 HMMPfam hit to PF04362, Fe(II) trafficking protein YggX, score 2.7e-62 550538014478 murein transglycosylase C; Provisional; Region: mltC; PRK11671 550538014479 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 550538014480 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538014481 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538014482 catalytic residue [active] 550538014483 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014484 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 9.7e-45 550538014485 PS00922 Prokaryotic transglycosylases signature. 550538014486 nucleoside transporter; Region: 2A0110; TIGR00889 550538014487 HMMPfam hit to PF03825, Nucleoside:H+ symporter, score 2.8e-284 550538014488 12 probable transmembrane helices predicted for SG3007 by TMHMM2.0 at aa 9-31, 41-63, 70-87, 92-114, 135-152, 162-184, 211-233, 253-275, 282-301, 311-333, 346-365 and 380-402 550538014490 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 7.9e-86 550538014491 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 0 550538014492 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 1.3e-32 550538014493 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 550538014494 HMMPfam hit to PF04474, Protein of unknown function DUF554, score 5e-111 550538014495 6 probable transmembrane helices predicted for SG3010 by TMHMM2.0 at aa 4-23, 36-58, 102-124, 145-167, 177-199 and 211-233 550538014496 Salmonella Pathogenicity Island 13; SPI-13 550538014497 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 550538014498 dimer interface [polypeptide binding]; other site 550538014499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 550538014500 metal binding site [ion binding]; metal-binding site 550538014501 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 1e-09 550538014502 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 550538014503 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 550538014504 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 550538014505 HMMPfam hit to PF02550, Acetyl-CoA hydrolase/transferase, score 2.1e-06 550538014506 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 550538014507 putative active site [active] 550538014508 putative catalytic site [active] 550538014509 HMMPfam hit to PF01575, MaoC-like dehydratase, score 9.5e-20 550538014510 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 550538014511 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 6.9e-27 550538014512 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538014513 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 550538014514 putative dimerization interface [polypeptide binding]; other site 550538014515 putative substrate binding pocket [chemical binding]; other site 550538014516 HMMPfam hit to PF03466, LysR, substrate-binding, score 2e-49 550538014517 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 550538014518 Sulfatase; Region: Sulfatase; pfam00884 550538014519 HMMPfam hit to PF00884, Sulphatase, score 3.8e-53 550538014520 PS00149 Sulfatases signature 2. 550538014521 PS00523 Sulfatases signature 1. 550538014522 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 550538014523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538014524 FeS/SAM binding site; other site 550538014525 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 550538014526 HMMPfam hit to PF04055, Radical SAM, score 7.8e-14 550538014527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 550538014528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538014529 DNA binding residues [nucleotide binding] 550538014530 dimerization interface [polypeptide binding]; other site 550538014531 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2.4e-17 550538014532 PS00622 Bacterial regulatory proteins, luxR family signature. 550538014533 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 550538014534 Amino acid permease; Region: AA_permease_2; pfam13520 550538014535 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.0005 550538014536 12 probable transmembrane helices predicted for SG3020 by TMHMM2.0 at aa 13-35, 48-70, 90-121, 136-158, 165-187, 202-224, 236-258, 293-315, 345-362, 372-394, 407-429 and 439-456 550538014537 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 550538014538 HMMPfam hit to PF05899, Protein of unknown function DUF861, cupin-3, score 2.5e-29 550538014539 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 550538014540 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 550538014541 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.4e-80 550538014542 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 550538014543 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 550538014544 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 550538014545 NAD(P) binding site [chemical binding]; other site 550538014546 catalytic residues [active] 550538014547 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.4e-195 550538014548 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538014549 PS00070 Aldehyde dehydrogenases cysteine active site. 550538014550 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 550538014551 HMMPfam hit to PF04965, GPW/gp25, score 0.00034 550538014552 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 550538014553 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 3.9e-65 550538014554 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 550538014555 active site 550538014556 catalytic site [active] 550538014557 Zn binding site [ion binding]; other site 550538014558 tetramer interface [polypeptide binding]; other site 550538014559 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 1.3e-25 550538014560 Predicted amidohydrolase [General function prediction only]; Region: COG0388 550538014561 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 550538014562 putative active site [active] 550538014563 catalytic triad [active] 550538014564 putative dimer interface [polypeptide binding]; other site 550538014565 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 1.3e-16 550538014566 PS00237 G-protein coupled receptors signature. 550538014567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538014568 D-galactonate transporter; Region: 2A0114; TIGR00893 550538014569 putative substrate translocation pore; other site 550538014570 9 probable transmembrane helices predicted for SG3028 by TMHMM2.0 at aa 65-87, 97-119, 132-154, 169-191, 236-258, 268-290, 311-333, 362-384 and 393-415 550538014571 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1e-64 550538014572 mannonate dehydratase; Provisional; Region: PRK03906 550538014573 mannonate dehydratase; Region: uxuA; TIGR00695 550538014574 HMMPfam hit to PF03786, Mannonate dehydratase, score 1.6e-290 550538014575 D-mannonate oxidoreductase; Provisional; Region: PRK15037 550538014576 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 550538014577 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 550538014578 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 8.4e-91 550538014579 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 3.3e-127 550538014580 PS00974 Mannitol dehydrogenases signature. 550538014581 PS00017 ATP/GTP-binding site motif A (P-loop). 550538014582 PS00215 Mitochondrial energy transfer proteins signature. 550538014583 Glucuronate isomerase; Region: UxaC; pfam02614 550538014584 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 550538014585 HMMPfam hit to PF02614, Glucuronate isomerase, score 6.2e-301 550538014586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538014587 dimer interface [polypeptide binding]; other site 550538014588 putative CheW interface [polypeptide binding]; other site 550538014589 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 550538014590 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 4.2e-17 550538014592 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 9.8e-16 550538014593 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 1.8e-36 550538014595 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 1.9e-06 550538014596 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 3.7e-08 550538014597 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 550538014598 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 550538014599 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 550538014600 putative ligand binding residues [chemical binding]; other site 550538014601 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 550538014602 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.5e-34 550538014603 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 550538014604 HMMPfam hit to PF01455, Hydrogenase expression/formation protein (HUPF/HYPC), score 9.3e-41 550538014605 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 550538014606 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 550538014607 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 550538014608 HMMPfam hit to PF01155, Hydrogenase expression/synthesis, HypA, score 4e-61 550538014609 PS01249 Hydrogenases expression/synthesis hypA family signature. 550538014610 PS00213 Lipocalin signature. 550538014611 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 550538014612 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 550538014613 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 550538014614 putative substrate-binding site; other site 550538014615 nickel binding site [ion binding]; other site 550538014616 HMMPfam hit to PF01750, Peptidase A31, hydrogen uptake protein, score 1e-48 550538014617 hydrogenase 2 large subunit; Provisional; Region: PRK10467 550538014618 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 550538014619 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, large subunit, score 0 550538014620 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 550538014621 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 550538014622 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 550538014623 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 550538014624 10 probable transmembrane helices predicted for SG3044 by TMHMM2.0 at aa 13-32, 52-74, 86-108, 128-150, 171-193, 208-227, 246-268, 283-302, 315-337 and 352-374 550538014625 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 0.001 550538014626 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 550538014627 4Fe-4S binding domain; Region: Fer4_6; pfam12837 550538014628 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.3e-06 550538014629 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538014630 hydrogenase 2 small subunit; Provisional; Region: PRK10468 550538014631 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 550538014632 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 550538014633 1 probable transmembrane helix predicted for SG3046 by TMHMM2.0 at aa 332-354 550538014634 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 0.00032 550538014635 HMMPfam hit to PF08425, NiFe dehydrogenase small subunit, N-terminal, score 2.1e-46 550538014636 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 550538014637 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 550538014638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538014639 dimerization interface [polypeptide binding]; other site 550538014640 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538014641 dimer interface [polypeptide binding]; other site 550538014642 putative CheW interface [polypeptide binding]; other site 550538014643 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 1.3e-98 550538014644 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.1e-06 550538014645 2 probable transmembrane helices predicted for SG3048 by TMHMM2.0 at aa 10-32 and 190-212 550538014646 hypothetical protein; Provisional; Region: PRK05208 550538014647 3 probable transmembrane helices predicted for SG3049 by TMHMM2.0 at aa 10-32, 53-75 and 136-155 550538014648 HMMPfam hit to PF03350, Protein of unknown function UPF0114, score 7.7e-55 550538014650 oxidoreductase; Provisional; Region: PRK07985 550538014651 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 550538014652 NAD binding site [chemical binding]; other site 550538014653 metal binding site [ion binding]; metal-binding site 550538014654 active site 550538014655 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1e-18 550538014656 PS00061 Short-chain dehydrogenases/reductases family signature. 550538014657 biopolymer transport protein ExbD; Provisional; Region: PRK11267 550538014658 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 550538014659 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 8.9e-21 550538014660 1 probable transmembrane helix predicted for SG3055 by TMHMM2.0 at aa 20-42 550538014661 biopolymer transport protein ExbB; Provisional; Region: PRK10414 550538014662 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 5.3e-51 550538014663 3 probable transmembrane helices predicted for SG3056 by TMHMM2.0 at aa 20-42, 131-153 and 177-199 550538014664 cystathionine beta-lyase; Provisional; Region: PRK08114 550538014665 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 550538014666 homodimer interface [polypeptide binding]; other site 550538014667 substrate-cofactor binding pocket; other site 550538014668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538014669 catalytic residue [active] 550538014670 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 2.1e-172 550538014671 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 550538014672 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 550538014673 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 550538014674 4 probable transmembrane helices predicted for SG3059 by TMHMM2.0 at aa 16-38, 66-88, 158-180 and 190-212 550538014675 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 4.7e-06 550538014676 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 550538014677 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 550538014678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538014679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538014680 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.2e-06 550538014681 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.4e-09 550538014682 HMMPfam hit to PF06719, AraC-type transcriptional regulator, N-terminal, score 1.5e-68 550538014683 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 550538014684 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 550538014685 dimer interface [polypeptide binding]; other site 550538014686 active site 550538014687 metal binding site [ion binding]; metal-binding site 550538014688 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 3.9e-14 550538014689 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538014690 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538014691 PS00060 Iron-containing alcohol dehydrogenases signature 2. 550538014692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 550538014693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 550538014694 active site 550538014695 catalytic tetrad [active] 550538014696 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.2e-124 550538014697 PS00798 Aldo/keto reductase family signature 1. 550538014698 PS00062 Aldo/keto reductase family signature 2. 550538014699 PS00063 Aldo/keto reductase family active site signature. 550538014700 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 550538014701 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 550538014702 transmembrane helices; other site 550538014703 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 2.9e-157 550538014704 10 probable transmembrane helices predicted for SG3063 by TMHMM2.0 at aa 7-25, 40-59, 80-97, 176-198, 228-247, 251-270, 283-305, 320-342, 349-371 and 408-430 550538014705 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 550538014706 nucleotide binding site/active site [active] 550538014707 catalytic residue [active] 550538014708 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 9.4e-09 550538014709 hypothetical protein; Provisional; Region: PRK01254 550538014710 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 550538014711 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 550538014712 HMMPfam hit to PF04055, Radical SAM, score 2.3e-12 550538014713 PS01278 Uncharacterized protein family UPF0004 signature. 550538014714 HMMPfam hit to PF08497, Radical SAM N-terminal, score 2.8e-279 550538014715 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 550538014716 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 550538014717 1 probable transmembrane helix predicted for SG3066 by TMHMM2.0 at aa 7-26 550538014718 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014719 HMMPfam hit to PF03480, TRAP dicarboxylate transporter- DctP subunit, score 3.2e-90 550538014720 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 550538014721 4 probable transmembrane helices predicted for SG3067 by TMHMM2.0 at aa 11-33, 48-65, 85-107 and 132-151 550538014722 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014723 HMMPfam hit to PF04290, Tripartite ATP-independent periplasmic transporter, DctQ component, score 3.2e-23 550538014724 DctM-like transporters; Region: DctM; pfam06808 550538014725 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 550538014726 11 probable transmembrane helices predicted for SG3068 by TMHMM2.0 at aa 7-29, 62-84, 105-127, 147-169, 176-198, 229-258, 279-301, 321-338, 343-360, 370-392 and 404-426 550538014727 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport system permease DctM subunit, score 2.1e-153 550538014728 FtsI repressor; Provisional; Region: PRK10883 550538014729 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 550538014730 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 550538014731 HMMPfam hit to PF07731, Multicopper oxidase, type 2, score 3.8e-18 550538014732 HMMPfam hit to PF07732, Multicopper oxidase, type 3, score 2.7e-38 550538014733 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 550538014734 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 550538014735 putative acyl-acceptor binding pocket; other site 550538014736 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 4.6e-49 550538014737 1 probable transmembrane helix predicted for SG3070 by TMHMM2.0 at aa 2-24 550538014738 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 550538014739 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 550538014740 CAP-like domain; other site 550538014741 active site 550538014742 primary dimer interface [polypeptide binding]; other site 550538014743 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 550538014744 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 7.7e-08 550538014745 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.7e-05 550538014746 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 6.3e-270 550538014747 the sequence has been checked and is believed to be correct 550538014748 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 1.6e-46 550538014749 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.2e-05 550538014750 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00093 550538014751 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 550538014752 HMMPfam hit to PF04076, Conserved hypothetical protein CHP00156, score 1.2e-79 550538014753 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 550538014754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538014755 active site 550538014756 phosphorylation site [posttranslational modification] 550538014757 intermolecular recognition site; other site 550538014758 dimerization interface [polypeptide binding]; other site 550538014759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538014760 DNA binding site [nucleotide binding] 550538014761 HMMPfam hit to PF00072, Response regulator receiver, score 2.6e-30 550538014762 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2.1e-22 550538014763 sensor protein QseC; Provisional; Region: PRK10337 550538014764 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 550538014765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538014766 dimer interface [polypeptide binding]; other site 550538014767 phosphorylation site [posttranslational modification] 550538014768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538014769 ATP binding site [chemical binding]; other site 550538014770 Mg2+ binding site [ion binding]; other site 550538014771 G-X-G motif; other site 550538014772 2 probable transmembrane helices predicted for SG3075 by TMHMM2.0 at aa 13-32 and 159-181 550538014773 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 4.3e-06 550538014774 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.2e-14 550538014775 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.8e-29 550538014776 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 550538014777 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.4e-75 550538014778 Uncharacterized conserved protein [Function unknown]; Region: COG1359 550538014779 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 1.8e-13 550538014780 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 550538014781 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 550538014782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538014783 ATP binding site [chemical binding]; other site 550538014784 Mg2+ binding site [ion binding]; other site 550538014785 G-X-G motif; other site 550538014786 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 550538014787 anchoring element; other site 550538014788 dimer interface [polypeptide binding]; other site 550538014789 ATP binding site [chemical binding]; other site 550538014790 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 550538014791 active site 550538014792 metal binding site [ion binding]; metal-binding site 550538014793 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 550538014794 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 1.1e-32 550538014795 PS00177 DNA topoisomerase II signature. 550538014796 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 1.9e-58 550538014797 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 9.4e-26 550538014798 esterase YqiA; Provisional; Region: PRK11071 550538014799 HMMPfam hit to PF05728, Protein of unknown function UPF0227, score 5.9e-109 550538014800 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 550538014801 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 550538014802 active site 550538014803 metal binding site [ion binding]; metal-binding site 550538014804 hexamer interface [polypeptide binding]; other site 550538014805 HMMPfam hit to PF08413, Calcineurin-like phosphoesterase C-terminal, score 1.2e-43 550538014806 HMMPfam hit to PF00149, Metallophosphoesterase, score 7.7e-21 550538014807 putative dehydrogenase; Provisional; Region: PRK11039 550538014808 HMMPfam hit to PF06853, Protein of unknown function DUF1249, score 6.3e-95 550538014809 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 550538014810 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 550538014811 dimer interface [polypeptide binding]; other site 550538014812 ADP-ribose binding site [chemical binding]; other site 550538014813 active site 550538014814 nudix motif; other site 550538014815 metal binding site [ion binding]; metal-binding site 550538014816 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 2e-23 550538014817 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 550538014818 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.8e-44 550538014819 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.3e-53 550538014820 hypothetical protein; Provisional; Region: PRK11653 550538014821 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538014822 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 550538014823 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 1.2e-265 550538014824 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 550538014825 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 550538014826 putative active site [active] 550538014827 metal binding site [ion binding]; metal-binding site 550538014828 HMMPfam hit to PF02900, Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B, score 6.3e-98 550538014829 zinc transporter ZupT; Provisional; Region: PRK04201 550538014830 ZIP Zinc transporter; Region: Zip; pfam02535 550538014831 8 probable transmembrane helices predicted for SG3087 by TMHMM2.0 at aa 5-24, 31-50, 65-87, 108-130, 140-162, 169-191, 195-217 and 234-256 550538014832 HMMPfam hit to PF02535, Zinc/iron permease, score 1.7e-51 550538014833 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 550538014834 1 probable transmembrane helix predicted for SG3088 by TMHMM2.0 at aa 9-31 550538014835 HMMPfam hit to PF05935, Arylsulphotransferase, score 0 550538014836 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 550538014837 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 550538014838 catalytic residues [active] 550538014839 hinge region; other site 550538014840 alpha helical domain; other site 550538014841 HMMPfam hit to PF01323, DSBA oxidoreductase, score 8.8e-06 550538014842 putative disulfide oxidoreductase; Provisional; Region: PRK04307 550538014843 4 probable transmembrane helices predicted for SG3090 by TMHMM2.0 at aa 27-49, 59-78, 83-105 and 197-219 550538014844 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 550538014845 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 550538014846 HMMPfam hit to PF00926, 3,4-Dihydroxy-2-butanone 4-phosphate synthase, score 1.6e-128 550538014847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 550538014848 HMMPfam hit to PF04380, Protein of unknown function DUF526, score 9.3e-48 550538014849 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 550538014850 HMMPfam hit to PF08971, Glycogen synthesis protein, score 7.2e-55 550538014851 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 550538014852 HMMPfam hit to PF07290, Protein of unknown function DUF1449, score 3.1e-149 550538014853 3 probable transmembrane helices predicted for SG3094 by TMHMM2.0 at aa 13-35, 63-85 and 98-117 550538014854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 550538014855 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 550538014856 2 probable transmembrane helices predicted for SG3095 by TMHMM2.0 at aa 11-33 and 46-68 550538014857 HMMPfam hit to PF01145, Band 7 protein, score 1.9e-40 550538014858 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 550538014859 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 550538014860 putative ribose interaction site [chemical binding]; other site 550538014861 putative ADP binding site [chemical binding]; other site 550538014862 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 550538014863 active site 550538014864 nucleotide binding site [chemical binding]; other site 550538014865 HIGH motif; other site 550538014866 KMSKS motif; other site 550538014867 HMMPfam hit to PF01467, Cytidylyltransferase, score 5.7e-24 550538014868 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.3e-61 550538014869 PS00583 pfkB family of carbohydrate kinases signature 1. 550538014870 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 550538014871 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 550538014872 metal binding triad; other site 550538014873 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 550538014874 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 550538014875 metal binding triad; other site 550538014876 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 550538014877 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 4.1e-151 550538014878 PS00904 Protein prenyltransferases alpha subunit repeat signature. 550538014879 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 1.8e-124 550538014880 Uncharacterized conserved protein [Function unknown]; Region: COG3025 550538014881 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 550538014882 putative active site [active] 550538014883 putative metal binding residues [ion binding]; other site 550538014884 signature motif; other site 550538014885 putative triphosphate binding site [ion binding]; other site 550538014886 CHAD domain; Region: CHAD; pfam05235 550538014887 HMMPfam hit to PF05235, CHAD, score 1.3e-36 550538014888 HMMPfam hit to PF01928, Adenylate cyclase, score 3.4e-69 550538014889 SH3 domain-containing protein; Provisional; Region: PRK10884 550538014890 Bacterial SH3 domain homologues; Region: SH3b; smart00287 550538014891 HMMPfam hit to PF08239, SH3, type 3, score 0.0022 550538014892 1 probable transmembrane helix predicted for SG3099 by TMHMM2.0 at aa 167-189 550538014893 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 550538014894 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 550538014895 active site 550538014896 NTP binding site [chemical binding]; other site 550538014897 metal binding triad [ion binding]; metal-binding site 550538014898 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 550538014899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 550538014900 Zn2+ binding site [ion binding]; other site 550538014901 Mg2+ binding site [ion binding]; other site 550538014902 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase region, score 6.3e-51 550538014903 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 8.4e-19 550538014904 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 550538014905 7 probable transmembrane helices predicted for SG3101 by TMHMM2.0 at aa 7-29, 49-71, 91-110, 120-137, 188-210, 225-247 and 254-273 550538014906 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 3.4e-154 550538014907 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 550538014908 homooctamer interface [polypeptide binding]; other site 550538014909 active site 550538014910 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 5.8e-52 550538014911 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 550538014912 5 probable transmembrane helices predicted for SG3103 by TMHMM2.0 at aa 4-26, 53-75, 80-102, 109-131 and 136-158 550538014913 HMMPfam hit to PF02660, Protein of unknown function DUF205, score 9.4e-108 550538014915 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 1.6e-13 550538014916 UGMP family protein; Validated; Region: PRK09604 550538014917 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 550538014918 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 3.4e-76 550538014919 PS01016 Glycoprotease family signature. 550538014920 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 550538014921 HMMPfam hit to PF01165, Ribosomal protein S21, score 2.7e-35 550538014922 PS01181 Ribosomal protein S21 signature. 550538014923 DNA primase; Validated; Region: dnaG; PRK05667 550538014924 CHC2 zinc finger; Region: zf-CHC2; pfam01807 550538014925 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 550538014926 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 550538014927 active site 550538014928 metal binding site [ion binding]; metal-binding site 550538014929 interdomain interaction site; other site 550538014930 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 550538014931 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 550538014932 HMMPfam hit to PF01807, Zinc finger, CHC2-type, score 3.5e-67 550538014933 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 2.5e-66 550538014934 PS00136 Serine proteases, subtilase family, aspartic acid active site. 550538014935 HMMPfam hit to PF01751, TOPRIM, score 1.3e-24 550538014936 HMMPfam hit to PF08278, DNA primase DnaG, DnaB-binding, score 1.2e-57 550538014937 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 550538014938 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 550538014939 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 550538014940 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 550538014941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 550538014942 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 550538014943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 550538014944 DNA binding residues [nucleotide binding] 550538014945 HMMPfam hit to PF03979, RNA polymerase sigma factor 70, region 1.1, score 3.5e-43 550538014946 HMMPfam hit to PF00140, RNA polymerase sigma-70 region 1.2, score 2.7e-15 550538014947 HMMPfam hit to PF04546, RNA polymerase sigma factor 70, non-essential region, score 1.1e-123 550538014948 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 2e-28 550538014949 PS00715 Sigma-70 factors family signature 1. 550538014950 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 9.6e-41 550538014951 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1.1e-24 550538014952 PS00716 Sigma-70 factors family signature 2. 550538014953 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 550538014954 active site 550538014955 SUMO-1 interface [polypeptide binding]; other site 550538014956 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 7.3e-25 550538014957 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 550538014958 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 550538014959 FAD binding pocket [chemical binding]; other site 550538014960 FAD binding motif [chemical binding]; other site 550538014961 phosphate binding motif [ion binding]; other site 550538014962 NAD binding pocket [chemical binding]; other site 550538014963 HMMPfam hit to PF04954, Siderophore-interacting protein, score 2.9e-40 550538014964 HMMPfam hit to PF08021, FAD-binding 9, siderophore-interacting, score 3.7e-52 550538014965 Predicted transcriptional regulators [Transcription]; Region: COG1695 550538014966 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 550538014967 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 1e-18 550538014968 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 550538014969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538014970 dimerization interface [polypeptide binding]; other site 550538014971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 550538014972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538014973 dimer interface [polypeptide binding]; other site 550538014974 putative CheW interface [polypeptide binding]; other site 550538014975 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 6.1e-70 550538014976 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.8e-13 550538014977 2 probable transmembrane helices predicted for SG3112 by TMHMM2.0 at aa 12-34 and 192-211 550538014978 PAS fold; Region: PAS_3; pfam08447 550538014979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538014980 putative active site [active] 550538014981 heme pocket [chemical binding]; other site 550538014982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 550538014983 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 550538014984 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538014985 dimer interface [polypeptide binding]; other site 550538014986 putative CheW interface [polypeptide binding]; other site 550538014987 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.8e-60 550538014988 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3.2e-05 550538014989 HMMPfam hit to PF08447, PAS fold-3, score 2.4e-16 550538014990 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 550538014991 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 550538014992 inhibitor-cofactor binding pocket; inhibition site 550538014993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538014994 catalytic residue [active] 550538014995 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.5e-180 550538014996 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 550538014997 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 550538014998 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 550538014999 active site 550538015000 FMN binding site [chemical binding]; other site 550538015001 2,4-decadienoyl-CoA binding site; other site 550538015002 catalytic residue [active] 550538015003 4Fe-4S cluster binding site [ion binding]; other site 550538015004 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 550538015005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538015006 HMMPfam hit to PF00724, NADH:flavin oxidoreductase/NADH oxidase, N-terminal, score 3.7e-145 550538015007 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.7e-08 550538015008 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 550538015009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538015010 S-adenosylmethionine binding site [chemical binding]; other site 550538015011 HMMPfam hit to PF05175, Methyltransferase small, score 7.2e-82 550538015012 PS00092 N-6 Adenine-specific DNA methylases signature. 550538015013 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 550538015014 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 5.2e-05 550538015015 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 550538015016 putative active site [active] 550538015017 1 probable transmembrane helix predicted for SG3118 by TMHMM2.0 at aa 19-41 550538015018 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 1.1e-41 550538015019 the sequence has been checked and is believed to be correct 550538015020 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 7.3e-42 550538015021 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 550538015022 9 probable transmembrane helices predicted for SG3120 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 114-136, 142-161, 198-220, 235-257, 264-286 and 290-312 550538015023 HMMPfam hit to PF03741, Integral membrane protein TerC, score 1.1e-61 550538015024 the sequence has been checked and is believed to be correct 550538015025 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 2.4e-171 550538015026 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 550538015027 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 550538015028 6 probable transmembrane helices predicted for SG3122 by TMHMM2.0 at aa 20-38, 40-62, 66-88, 123-145, 155-177 and 190-212 550538015029 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 8.1e-08 550538015030 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 550538015031 1 probable transmembrane helix predicted for SG3123 by TMHMM2.0 at aa 12-31 550538015032 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 550538015033 HMMPfam hit to PF06476, Protein of unknown function DUF1090, score 2.2e-53 550538015034 Predicted membrane protein [Function unknown]; Region: COG5393 550538015035 2 probable transmembrane helices predicted for SG3126 by TMHMM2.0 at aa 50-72 and 82-104 550538015036 YqjK-like protein; Region: YqjK; pfam13997 550538015037 Predicted membrane protein [Function unknown]; Region: COG2259 550538015038 HMMPfam hit to PF07681, DoxX, score 5.3e-27 550538015039 4 probable transmembrane helices predicted for SG3128 by TMHMM2.0 at aa 40-62, 77-99, 104-121 and 136-153 550538015040 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 550538015041 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 550538015042 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 550538015043 putative dimer interface [polypeptide binding]; other site 550538015044 N-terminal domain interface [polypeptide binding]; other site 550538015045 putative substrate binding pocket (H-site) [chemical binding]; other site 550538015046 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 8.4e-05 550538015047 Predicted membrane protein [Function unknown]; Region: COG3152 550538015048 HMMPfam hit to PF05656, Protein of unknown function DUF805, score 1.6e-45 550538015049 3 probable transmembrane helices predicted for SG3130 by TMHMM2.0 at aa 24-46, 51-70 and 82-101 550538015050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538015051 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 550538015052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538015053 dimerization interface [polypeptide binding]; other site 550538015054 HMMPfam hit to PF03466, LysR, substrate-binding, score 4e-15 550538015055 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.2e-15 550538015056 PS00044 Bacterial regulatory proteins, lysR family signature. 550538015057 Pirin-related protein [General function prediction only]; Region: COG1741 550538015058 Pirin; Region: Pirin; pfam02678 550538015059 HMMPfam hit to PF02678, Pirin, N-terminal, score 4.5e-41 550538015060 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 550538015061 HMMPfam hit to PF06354, Protein of unknown function DUF1063, score 8.2e-258 550538015062 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 550538015063 serine transporter; Region: stp; TIGR00814 550538015064 11 probable transmembrane helices predicted for SG3135 by TMHMM2.0 at aa 38-60, 65-87, 112-134, 149-171, 184-206, 221-243, 264-286, 318-340, 363-385, 389-411 and 423-442 550538015066 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 4.3e-193 550538015067 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 4.7e-90 550538015068 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 550538015069 Pyruvate formate lyase 1; Region: PFL1; cd01678 550538015070 coenzyme A binding site [chemical binding]; other site 550538015071 active site 550538015072 catalytic residues [active] 550538015073 glycine loop; other site 550538015074 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 7.2e-60 550538015075 PS00850 Glycine radical signature. 550538015076 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 550538015077 propionate/acetate kinase; Provisional; Region: PRK12379 550538015078 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 550538015079 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 9.5e-225 550538015080 PS01076 Acetate and butyrate kinases family signature 2. 550538015081 PS01075 Acetate and butyrate kinases family signature 1. 550538015082 threonine/serine transporter TdcC; Provisional; Region: PRK13629 550538015083 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 550538015084 11 probable transmembrane helices predicted for SG3140 by TMHMM2.0 at aa 23-40, 44-66, 97-119, 134-156, 163-185, 212-234, 255-277, 315-337, 358-380, 390-409 and 422-440 550538015085 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 550538015086 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 550538015087 tetramer interface [polypeptide binding]; other site 550538015088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538015089 catalytic residue [active] 550538015090 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 5.4e-96 550538015091 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 550538015092 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 550538015093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538015094 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 550538015095 putative substrate binding pocket [chemical binding]; other site 550538015096 putative dimerization interface [polypeptide binding]; other site 550538015097 HMMPfam hit to PF03466, LysR, substrate-binding, score 2e-29 550538015098 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.1e-21 550538015099 PS00044 Bacterial regulatory proteins, lysR family signature. 550538015100 glycerate kinase I; Provisional; Region: PRK10342 550538015101 HMMPfam hit to PF02595, Glycerate kinase, score 6.6e-266 550538015102 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015103 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 550538015104 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 550538015105 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 2.5e-81 550538015106 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 550538015107 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 550538015108 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 3.6e-99 550538015109 galactarate dehydratase; Region: galactar-dH20; TIGR03248 550538015110 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 550538015111 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 550538015112 HMMPfam hit to PF08666, SAF domain, score 1.7e-12 550538015113 HMMPfam hit to PF04295, D-galactarate dehydratase/Altronate hydrolase, C-terminal, score 9.9e-249 550538015114 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 550538015115 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 550538015116 intersubunit interface [polypeptide binding]; other site 550538015117 active site 550538015118 zinc binding site [ion binding]; other site 550538015119 Na+ binding site [ion binding]; other site 550538015120 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 1.3e-141 550538015121 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 550538015122 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 550538015123 HMMPfam hit to PF08013, D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit AgaZ, score 0 550538015124 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538015125 active site 550538015126 phosphorylation site [posttranslational modification] 550538015127 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 8.5e-07 550538015128 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 550538015129 active site 550538015130 P-loop; other site 550538015131 phosphorylation site [posttranslational modification] 550538015132 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.2e-16 550538015133 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 550538015134 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 550538015135 9 probable transmembrane helices predicted for SG3151 by TMHMM2.0 at aa 4-26, 39-61, 91-113, 134-156, 225-247, 299-321, 331-348, 353-375 and 411-433 550538015136 PS00962 Ribosomal protein S2 signature 1. 550538015137 HMMPfam hit to PF03611, Phosphotransferase system, galactitol-specific IIC component, score 1.7e-185 550538015138 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 550538015139 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 550538015140 putative NAD(P) binding site [chemical binding]; other site 550538015141 catalytic Zn binding site [ion binding]; other site 550538015142 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1e-40 550538015143 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538015144 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 4.7e-36 550538015145 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538015146 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538015147 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538015148 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2.4e-18 550538015149 PS00894 Bacterial regulatory proteins, deoR family signature. 550538015150 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 4.5e-53 550538015151 PS00141 Eukaryotic and viral aspartyl proteases active site. 550538015152 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 550538015153 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 550538015154 putative SAM binding site [chemical binding]; other site 550538015155 putative homodimer interface [polypeptide binding]; other site 550538015156 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 6.1e-72 550538015157 PS01296 Uncharacterized protein family UPF0011 signature. 550538015158 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 550538015159 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 550538015160 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 550538015161 putative ligand binding site [chemical binding]; other site 550538015162 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538015163 HMMPfam hit to PF04348, LppC lipoprotein, score 1.1e-106 550538015164 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015165 TIGR00252 family protein; Region: TIGR00252 550538015166 HMMPfam hit to PF02021, Protein of unknown function UPF0102, score 4.8e-56 550538015167 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 550538015168 dimer interface [polypeptide binding]; other site 550538015169 active site 550538015170 outer membrane lipoprotein; Provisional; Region: PRK11023 550538015171 BON domain; Region: BON; pfam04972 550538015172 BON domain; Region: BON; pfam04972 550538015173 1 probable transmembrane helix predicted for SG3158 by TMHMM2.0 at aa 7-29 550538015174 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538015175 HMMPfam hit to PF04972, Transport-associated, score 2.4e-09 550538015176 HMMPfam hit to PF04972, Transport-associated, score 1.6e-11 550538015177 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 550538015178 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 550538015179 NAD binding site [chemical binding]; other site 550538015180 active site 550538015181 intracellular protease, PfpI family; Region: PfpI; TIGR01382 550538015182 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 550538015183 proposed catalytic triad [active] 550538015184 conserved cys residue [active] 550538015185 HMMPfam hit to PF01965, ThiJ/PfpI, score 4.8e-57 550538015186 hypothetical protein; Provisional; Region: PRK03467 550538015187 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 550538015188 GIY-YIG motif/motif A; other site 550538015189 putative active site [active] 550538015190 putative metal binding site [ion binding]; other site 550538015191 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 1.5e-15 550538015192 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 550538015193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538015194 Coenzyme A binding pocket [chemical binding]; other site 550538015195 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.7e-15 550538015196 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 550538015197 HMMPfam hit to PF02036, Sterol-binding, score 1.7e-27 550538015198 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 550538015199 Peptidase family U32; Region: Peptidase_U32; pfam01136 550538015200 HMMPfam hit to PF01136, Peptidase U32, score 1.5e-122 550538015201 PS01276 Peptidase family U32 signature. 550538015202 putative protease; Provisional; Region: PRK15447 550538015203 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 550538015204 HMMPfam hit to PF01136, Peptidase U32, score 1.5e-07 550538015205 hypothetical protein; Provisional; Region: PRK10508 550538015206 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 550538015207 HMMPfam hit to PF00296, Bacterial luciferase-like, score 7.6e-14 550538015208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 550538015209 HMMPfam hit to PF06104, Protein of unknown function DUF949, bacterial, score 7.2e-152 550538015210 1 probable transmembrane helix predicted for SG3168 by TMHMM2.0 at aa 5-27 550538015211 tryptophan permease; Provisional; Region: PRK10483 550538015212 aromatic amino acid transport protein; Region: araaP; TIGR00837 550538015213 10 probable transmembrane helices predicted for SG3170 by TMHMM2.0 at aa 10-32, 59-81, 96-118, 125-147, 162-184, 197-219, 256-278, 290-312, 317-339 and 360-382 550538015214 HMMPfam hit to PF03222, Aromatic amino acid permease, score 5.3e-221 550538015215 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 550538015216 DEAD-like helicases superfamily; Region: DEXDc; smart00487 550538015217 ATP binding site [chemical binding]; other site 550538015218 Mg++ binding site [ion binding]; other site 550538015219 motif III; other site 550538015220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538015221 nucleotide binding region [chemical binding]; other site 550538015222 ATP-binding site [chemical binding]; other site 550538015223 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 550538015224 putative RNA binding site [nucleotide binding]; other site 550538015225 HMMPfam hit to PF03880, DbpA, RNA-binding, score 2.8e-42 550538015226 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 2.7e-34 550538015227 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 8.6e-76 550538015228 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 550538015229 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015230 lipoprotein NlpI; Provisional; Region: PRK11189 550538015231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 550538015232 binding surface 550538015233 TPR motif; other site 550538015234 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.22 550538015235 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 1.2e-06 550538015236 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.00013 550538015237 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538015238 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 550538015239 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 550538015240 RNase E interface [polypeptide binding]; other site 550538015241 trimer interface [polypeptide binding]; other site 550538015242 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 550538015243 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 550538015244 RNase E interface [polypeptide binding]; other site 550538015245 trimer interface [polypeptide binding]; other site 550538015246 active site 550538015247 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 550538015248 putative nucleic acid binding region [nucleotide binding]; other site 550538015249 G-X-X-G motif; other site 550538015250 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 550538015251 RNA binding site [nucleotide binding]; other site 550538015252 domain interface; other site 550538015253 HMMPfam hit to PF00575, S1, RNA binding, score 3.2e-27 550538015254 HMMPfam hit to PF00013, K Homology, type 1, score 1.4e-15 550538015255 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 9.7e-22 550538015256 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 1e-54 550538015257 HMMPfam hit to PF03726, Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type, score 1.6e-38 550538015258 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 6e-19 550538015259 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 9.2e-44 550538015260 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 550538015261 16S/18S rRNA binding site [nucleotide binding]; other site 550538015262 S13e-L30e interaction site [polypeptide binding]; other site 550538015263 25S rRNA binding site [nucleotide binding]; other site 550538015264 HMMPfam hit to PF00312, Ribosomal protein S15, score 2.8e-48 550538015265 PS00362 Ribosomal protein S15 signature. 550538015266 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 550538015267 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 550538015268 RNA binding site [nucleotide binding]; other site 550538015269 active site 550538015270 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 550538015271 HMMPfam hit to PF09157, tRNA pseudouridine synthase B, C-terminal, score 7.8e-28 550538015272 HMMPfam hit to PF01509, tRNA pseudouridine synthase B, N-terminal, score 2.4e-93 550538015273 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 550538015274 HMMPfam hit to PF02033, Ribosome-binding factor A, score 1e-64 550538015275 PS01319 Ribosome-binding factor A signature. 550538015276 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 550538015277 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 550538015278 translation initiation factor IF-2; Region: IF-2; TIGR00487 550538015279 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 550538015280 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 550538015281 G1 box; other site 550538015282 putative GEF interaction site [polypeptide binding]; other site 550538015283 GTP/Mg2+ binding site [chemical binding]; other site 550538015284 Switch I region; other site 550538015285 G2 box; other site 550538015286 G3 box; other site 550538015287 Switch II region; other site 550538015288 G4 box; other site 550538015289 G5 box; other site 550538015290 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 550538015291 Translation-initiation factor 2; Region: IF-2; pfam11987 550538015292 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 550538015293 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 6.5e-11 550538015294 PS01176 Initiation factor 2 signature. 550538015295 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.2e-13 550538015296 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.9e-56 550538015297 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015298 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 3.6e-21 550538015299 HMMPfam hit to PF08364, Initiation factor 2 associated region, bacterial, score 3e-21 550538015300 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 4.3e-08 550538015301 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 550538015302 NusA N-terminal domain; Region: NusA_N; pfam08529 550538015303 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 550538015304 RNA binding site [nucleotide binding]; other site 550538015305 homodimer interface [polypeptide binding]; other site 550538015306 NusA-like KH domain; Region: KH_5; pfam13184 550538015307 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 550538015308 G-X-X-G motif; other site 550538015309 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 550538015310 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 550538015311 HMMPfam hit to PF00575, S1, RNA binding, score 2.4e-07 550538015312 HMMPfam hit to PF08529, Transcription factor NusA, N-terminal, score 2.4e-67 550538015313 ribosome maturation protein RimP; Reviewed; Region: PRK00092 550538015314 Sm and related proteins; Region: Sm_like; cl00259 550538015315 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 550538015316 putative oligomer interface [polypeptide binding]; other site 550538015317 putative RNA binding site [nucleotide binding]; other site 550538015318 HMMPfam hit to PF02576, Protein of unknown function DUF150, score 3e-72 550538015319 argininosuccinate synthase; Validated; Region: PRK05370 550538015320 argininosuccinate synthase; Provisional; Region: PRK13820 550538015321 HMMPfam hit to PF00764, Argininosuccinate synthase, score 8.4e-218 550538015322 PS00564 Argininosuccinate synthase signature 1. 550538015323 PS00565 Argininosuccinate synthase signature 2. 550538015325 Preprotein translocase SecG subunit; Region: SecG; pfam03840 550538015326 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 1.3e-35 550538015327 2 probable transmembrane helices predicted for SG3183 by TMHMM2.0 at aa 5-22 and 51-73 550538015328 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 550538015329 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 550538015330 active site 550538015331 substrate binding site [chemical binding]; other site 550538015332 metal binding site [ion binding]; metal-binding site 550538015333 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 4.1e-20 550538015334 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 2.2e-41 550538015335 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 1.1e-46 550538015336 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 1.9e-62 550538015337 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 550538015338 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 550538015339 dihydropteroate synthase; Region: DHPS; TIGR01496 550538015340 substrate binding pocket [chemical binding]; other site 550538015341 dimer interface [polypeptide binding]; other site 550538015342 inhibitor binding site; inhibition site 550538015343 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 9.6e-106 550538015344 PS00793 Dihydropteroate synthase signature 2. 550538015345 PS00792 Dihydropteroate synthase signature 1. 550538015346 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 550538015347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538015348 Walker A motif; other site 550538015349 ATP binding site [chemical binding]; other site 550538015350 Walker B motif; other site 550538015351 arginine finger; other site 550538015352 Peptidase family M41; Region: Peptidase_M41; pfam01434 550538015353 HMMPfam hit to PF01434, Peptidase M41, score 1.7e-129 550538015354 HMMPfam hit to PF00004, AAA ATPase, core, score 6e-102 550538015355 PS00674 AAA-protein family signature. 550538015356 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015357 HMMPfam hit to PF06480, Peptidase M41, FtsH extracellular, score 3.1e-50 550538015358 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015359 2 probable transmembrane helices predicted for SG3186 by TMHMM2.0 at aa 5-24 and 97-119 550538015360 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 550538015361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538015362 S-adenosylmethionine binding site [chemical binding]; other site 550538015363 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 2.3e-77 550538015364 RNA-binding protein YhbY; Provisional; Region: PRK10343 550538015365 HMMPfam hit to PF01985, CRS1/YhbY, score 2.9e-38 550538015366 PS01301 Uncharacterized protein family UPF0044 signature. 550538015367 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 550538015368 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 550538015369 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 550538015370 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 3.7e-46 550538015371 PS00830 Prokaryotic transcription elongation factors signature 2. 550538015372 HMMPfam hit to PF03449, Transcription elongation factor, GreA/GreB region, prokaryotic, score 3.9e-48 550538015373 PS00829 Prokaryotic transcription elongation factors signature 1. 550538015374 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 550538015375 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 550538015376 HMMPfam hit to PF02113, Peptidase S13, D-Ala-D-Ala carboxypeptidase C, score 1.9e-211 550538015377 GTPase CgtA; Reviewed; Region: obgE; PRK12298 550538015378 GTP1/OBG; Region: GTP1_OBG; pfam01018 550538015379 Obg GTPase; Region: Obg; cd01898 550538015380 G1 box; other site 550538015381 GTP/Mg2+ binding site [chemical binding]; other site 550538015382 Switch I region; other site 550538015383 G2 box; other site 550538015384 G3 box; other site 550538015385 Switch II region; other site 550538015386 G4 box; other site 550538015387 G5 box; other site 550538015388 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 4.4e-38 550538015389 PS00905 GTP1/OBG family signature. 550538015390 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015391 HMMPfam hit to PF01018, GTP1/OBG subdomain, score 4.5e-107 550538015392 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 550538015393 EamA-like transporter family; Region: EamA; pfam00892 550538015394 EamA-like transporter family; Region: EamA; pfam00892 550538015395 10 probable transmembrane helices predicted for SG3192 by TMHMM2.0 at aa 20-39, 54-73, 86-108, 118-135, 144-166, 170-192, 205-227, 232-254, 261-283 and 293-315 550538015396 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 5.9e-15 550538015397 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.5e-27 550538015398 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 550538015399 HMMPfam hit to PF01016, Ribosomal protein L27, score 2.5e-57 550538015400 PS00831 Ribosomal protein L27 signature. 550538015401 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 550538015402 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 550538015403 HMMPfam hit to PF00829, Ribosomal protein L21, score 5.9e-57 550538015404 PS01169 Ribosomal protein L21 signature. 550538015405 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 550538015406 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 550538015407 substrate binding pocket [chemical binding]; other site 550538015408 chain length determination region; other site 550538015409 substrate-Mg2+ binding site; other site 550538015410 catalytic residues [active] 550538015411 aspartate-rich region 1; other site 550538015412 active site lid residues [active] 550538015413 aspartate-rich region 2; other site 550538015414 HMMPfam hit to PF00348, Polyprenyl synthetase, score 1.2e-127 550538015415 PS00723 Polyprenyl synthetases signature 1. 550538015416 PS00444 Polyprenyl synthetases signature 2. 550538015417 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 550538015418 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 550538015419 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 550538015420 hinge; other site 550538015421 active site 550538015422 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 6e-189 550538015423 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 550538015424 HMMPfam hit to PF01722, BolA-like protein, score 5.1e-38 550538015425 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 550538015426 anti sigma factor interaction site; other site 550538015427 regulatory phosphorylation site [posttranslational modification]; other site 550538015428 HMMPfam hit to PF01740, Sulphate transporter/antisigma-factor antagonist STAS, score 0.00018 550538015429 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 550538015430 HMMPfam hit to PF05494, Toluene tolerance, score 1.8e-97 550538015431 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 550538015432 mce related protein; Region: MCE; pfam02470 550538015433 HMMPfam hit to PF02470, Mammalian cell entry related, score 4.8e-25 550538015434 1 probable transmembrane helix predicted for SG3201 by TMHMM2.0 at aa 9-31 550538015435 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 550538015436 conserved hypothetical integral membrane protein; Region: TIGR00056 550538015437 HMMPfam hit to PF02405, Protein of unknown function DUF140, score 7.2e-128 550538015438 5 probable transmembrane helices predicted for SG3202 by TMHMM2.0 at aa 48-70, 85-107, 148-170, 197-219 and 239-258 550538015439 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 550538015440 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 550538015441 Walker A/P-loop; other site 550538015442 ATP binding site [chemical binding]; other site 550538015443 Q-loop/lid; other site 550538015444 ABC transporter signature motif; other site 550538015445 Walker B; other site 550538015446 D-loop; other site 550538015447 H-loop/switch region; other site 550538015448 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-53 550538015449 PS00211 ABC transporters family signature. 550538015450 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015451 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 550538015452 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 550538015453 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 550538015454 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 5.9e-41 550538015455 9 probable transmembrane helices predicted for SG3204 by TMHMM2.0 at aa 13-35, 55-77, 86-105, 115-137, 158-180, 190-212, 225-247, 257-276 and 283-305 550538015456 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 4.2e-37 550538015457 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 550538015458 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 550538015459 putative active site [active] 550538015460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 550538015461 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 5.5e-38 550538015462 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.2e-19 550538015463 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 550538015464 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 550538015465 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.5e-08 550538015466 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 550538015467 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 550538015468 1 probable transmembrane helix predicted for SG3207 by TMHMM2.0 at aa 7-25 550538015469 HMMPfam hit to PF06835, Protein of unknown function DUF1239, score 3.7e-62 550538015470 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 550538015471 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 550538015472 HMMPfam hit to PF03968, OstA-like protein, score 2e-59 550538015473 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 550538015474 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 550538015475 Walker A/P-loop; other site 550538015476 ATP binding site [chemical binding]; other site 550538015477 Q-loop/lid; other site 550538015478 ABC transporter signature motif; other site 550538015479 Walker B; other site 550538015480 D-loop; other site 550538015481 H-loop/switch region; other site 550538015482 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-56 550538015483 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015484 PS00211 ABC transporters family signature. 550538015485 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 550538015486 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 550538015487 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 550538015488 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 550538015489 HMMPfam hit to PF00309, RNA polymerase sigma factor 54, score 1.6e-19 550538015490 HMMPfam hit to PF04963, RNA polymerase sigma factor 54, core-binding, score 1.8e-124 550538015491 HMMPfam hit to PF04552, RNA polymerase sigma factor 54, DNA-binding, score 1.1e-107 550538015492 PS00717 Sigma-54 factors family signature 1. 550538015493 PS00718 Sigma-54 factors family signature 2. 550538015494 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 550538015495 30S subunit binding site; other site 550538015496 HMMPfam hit to PF02482, Ribosomal protein S30Ae/sigma 54 modulation protein, score 1e-52 550538015497 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538015498 active site 550538015499 phosphorylation site [posttranslational modification] 550538015500 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 1.3e-65 550538015501 PS00372 PTS EIIA domains phosphorylation site signature 2. 550538015502 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 550538015503 HMMPfam hit to PF03668, P-loop ATPase protein, score 1.2e-216 550538015504 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015505 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 550538015506 dimerization domain swap beta strand [polypeptide binding]; other site 550538015507 regulatory protein interface [polypeptide binding]; other site 550538015508 active site 550538015509 regulatory phosphorylation site [posttranslational modification]; other site 550538015510 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 8.6e-43 550538015511 PS00369 PTS HPR component histidine phosphorylation site signature. 550538015512 PS00589 PTS HPR component serine phosphorylation site signature. 550538015513 hypothetical protein; Provisional; Region: PRK10345 550538015514 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 550538015515 Transglycosylase; Region: Transgly; cl17702 550538015516 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 3.2e-79 550538015517 1 probable transmembrane helix predicted for SG3216 by TMHMM2.0 at aa 19-41 550538015518 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 550538015519 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 550538015520 conserved cys residue [active] 550538015521 HMMPfam hit to PF01965, ThiJ/PfpI, score 3e-24 550538015522 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 550538015523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538015524 putative active site [active] 550538015525 heme pocket [chemical binding]; other site 550538015526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538015527 dimer interface [polypeptide binding]; other site 550538015528 phosphorylation site [posttranslational modification] 550538015529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538015530 ATP binding site [chemical binding]; other site 550538015531 Mg2+ binding site [ion binding]; other site 550538015532 G-X-G motif; other site 550538015533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538015534 active site 550538015535 phosphorylation site [posttranslational modification] 550538015536 intermolecular recognition site; other site 550538015537 dimerization interface [polypeptide binding]; other site 550538015538 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 550538015539 putative binding surface; other site 550538015540 active site 550538015541 HMMPfam hit to PF01627, Hpt, score 4.5e-13 550538015542 HMMPfam hit to PF00072, Response regulator receiver, score 7.4e-37 550538015543 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.3e-41 550538015544 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 4.2e-21 550538015545 HMMPfam hit to PF00989, PAS fold, score 2.9e-27 550538015546 2 probable transmembrane helices predicted for SG3218 by TMHMM2.0 at aa 20-42 and 55-77 550538015547 radical SAM protein, TIGR01212 family; Region: TIGR01212 550538015548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538015549 FeS/SAM binding site; other site 550538015550 HMMPfam hit to PF04055, Radical SAM, score 9.3e-13 550538015551 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 550538015552 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 550538015553 active site 550538015554 dimer interface [polypeptide binding]; other site 550538015555 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 550538015556 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 550538015557 active site 550538015558 FMN binding site [chemical binding]; other site 550538015559 substrate binding site [chemical binding]; other site 550538015560 3Fe-4S cluster binding site [ion binding]; other site 550538015561 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 550538015562 domain interface; other site 550538015563 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1.6e-232 550538015564 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015565 HMMPfam hit to PF04898, Glutamate synthase, central-N, score 1.4e-175 550538015566 HMMPfam hit to PF01645, Glutamate synthase, central-C, score 5.1e-242 550538015567 HMMPfam hit to PF01493, Glutamate synthase, alpha subunit, C-terminal, score 9.9e-106 550538015568 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 550538015569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538015570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538015571 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5.1e-26 550538015572 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 0.0015 550538015573 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 550538015574 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 550538015575 HMMPfam hit to PF06250, Protein of unknown function DUF1016, score 8.9e-196 550538015576 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 550538015577 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 550538015578 Na binding site [ion binding]; other site 550538015579 putative substrate binding site [chemical binding]; other site 550538015580 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil, thiamine, allantoin, score 4.6e-96 550538015581 12 probable transmembrane helices predicted for SG3223 by TMHMM2.0 at aa 21-43, 53-75, 96-118, 128-150, 152-174, 189-211, 223-245, 255-277, 296-318, 323-345, 358-375 and 380-402 550538015582 cytosine deaminase; Provisional; Region: PRK09230 550538015583 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 550538015584 active site 550538015585 HMMPfam hit to PF07969, Amidohydrolase 3, score 1.6e-78 550538015586 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 550538015587 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 1.9e-71 550538015588 N-acetylmannosamine kinase; Provisional; Region: PRK05082 550538015589 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538015590 nucleotide binding site [chemical binding]; other site 550538015591 HMMPfam hit to PF00480, ROK, score 1.3e-70 550538015592 PS01125 ROK family signature. 550538015593 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 550538015594 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 550538015595 putative active site cavity [active] 550538015596 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epimerase, score 3.6e-126 550538015597 putative sialic acid transporter; Provisional; Region: PRK03893 550538015598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538015599 putative substrate translocation pore; other site 550538015600 14 probable transmembrane helices predicted for SG3228 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-166, 171-190, 224-243, 248-267, 280-302, 312-334, 347-369, 373-395, 404-426 and 431-453 550538015601 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 7.3e-39 550538015602 N-acetylneuraminate lyase; Provisional; Region: PRK04147 550538015603 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 550538015604 inhibitor site; inhibition site 550538015605 active site 550538015606 dimer interface [polypeptide binding]; other site 550538015607 catalytic residue [active] 550538015608 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 2.7e-146 550538015609 PS00666 Dihydrodipicolinate synthetase signature 2. 550538015610 PS00665 Dihydrodipicolinate synthetase signature 1. 550538015611 transcriptional regulator NanR; Provisional; Region: PRK03837 550538015612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538015613 DNA-binding site [nucleotide binding]; DNA binding site 550538015614 FCD domain; Region: FCD; pfam07729 550538015615 HMMPfam hit to PF07729, GntR, C-terminal, score 2.5e-30 550538015616 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.7e-26 550538015617 PS00043 Bacterial regulatory proteins, gntR family signature. 550538015618 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 550538015619 HMMPfam hit to PF04386, Stringent starvation protein B, score 9.3e-96 550538015620 stringent starvation protein A; Provisional; Region: sspA; PRK09481 550538015621 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 550538015622 C-terminal domain interface [polypeptide binding]; other site 550538015623 putative GSH binding site (G-site) [chemical binding]; other site 550538015624 dimer interface [polypeptide binding]; other site 550538015625 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 550538015626 dimer interface [polypeptide binding]; other site 550538015627 N-terminal domain interface [polypeptide binding]; other site 550538015628 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 1.5e-14 550538015629 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 5.3e-24 550538015630 Family of unknown function (DUF695); Region: DUF695; pfam05117 550538015631 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 550538015632 HMMPfam hit to PF06877, Protein of unknown function DUF1260, score 2.5e-39 550538015633 HMMPfam hit to PF05117, Conserved hypothetical protein CHP01619, score 2e-80 550538015634 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 550538015635 HMMPfam hit to PF00380, Ribosomal protein S9, score 2.6e-64 550538015636 PS00360 Ribosomal protein S9 signature. 550538015637 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 550538015638 23S rRNA interface [nucleotide binding]; other site 550538015639 L3 interface [polypeptide binding]; other site 550538015640 HMMPfam hit to PF00572, Ribosomal protein L13, score 9.4e-89 550538015641 PS00783 Ribosomal protein L13 signature. 550538015642 Predicted ATPase [General function prediction only]; Region: COG1485 550538015643 HMMPfam hit to PF03969, AFG1-like ATPase, score 1e-216 550538015644 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 550538015646 hypothetical protein; Provisional; Region: PRK11677 550538015647 1 probable transmembrane helix predicted for SG3237 by TMHMM2.0 at aa 4-26 550538015648 HMMPfam hit to PF06295, Protein of unknown function DUF1043, score 1.1e-83 550538015649 serine endoprotease; Provisional; Region: PRK10139 550538015650 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 550538015651 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 550538015652 protein binding site [polypeptide binding]; other site 550538015653 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 550538015654 1 probable transmembrane helix predicted for SG3238 by TMHMM2.0 at aa 7-29 550538015655 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 3.9e-21 550538015656 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 6.4e-21 550538015657 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 3.7e-13 550538015658 serine endoprotease; Provisional; Region: PRK10898 550538015659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 550538015660 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 550538015661 1 probable transmembrane helix predicted for SG3239 by TMHMM2.0 at aa 5-27 550538015662 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 2.2e-27 550538015663 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 4.9e-16 550538015664 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 550538015665 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 550538015666 9 probable transmembrane helices predicted for SG3241 by TMHMM2.0 at aa 13-35, 122-144, 159-178, 180-202, 222-244, 266-288, 308-327, 339-361 and 409-431 550538015667 HMMPfam hit to PF03977, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit, score 2.5e-289 550538015668 oxaloacetate decarboxylase; Provisional; Region: PRK14040 550538015669 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 550538015670 active site 550538015671 catalytic residues [active] 550538015672 metal binding site [ion binding]; metal-binding site 550538015673 homodimer binding site [polypeptide binding]; other site 550538015674 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 550538015675 carboxyltransferase (CT) interaction site; other site 550538015676 biotinylation site [posttranslational modification]; other site 550538015677 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2e-27 550538015678 PS00188 Biotin-requiring enzymes attachment site. 550538015679 HMMPfam hit to PF02436, Conserved carboxylase region, score 3.8e-99 550538015680 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 550538015681 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 3.3e-90 550538015682 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 550538015683 HMMPfam hit to PF04277, Sodium ion-translocating decarboxylase, score 1.1e-31 550538015684 1 probable transmembrane helix predicted for SG3243 by TMHMM2.0 at aa 11-33 550538015685 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 550538015686 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 7.6e-35 550538015687 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 550538015688 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 8.3e-142 550538015689 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 550538015690 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 550538015691 transmembrane helices; other site 550538015692 11 probable transmembrane helices predicted for SG3246 by TMHMM2.0 at aa 4-20, 25-44, 49-71, 92-121, 136-158, 171-193, 244-266, 279-301, 316-338, 359-378 and 398-420 550538015693 HMMPfam hit to PF03600, Divalent ion symporter, score 4.8e-09 550538015694 Transcriptional regulators [Transcription]; Region: GntR; COG1802 550538015695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538015696 DNA-binding site [nucleotide binding]; DNA binding site 550538015697 FCD domain; Region: FCD; pfam07729 550538015698 HMMPfam hit to PF07729, GntR, C-terminal, score 9.5e-14 550538015699 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.5e-16 550538015700 Transcriptional regulators [Transcription]; Region: GntR; COG1802 550538015701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538015702 DNA-binding site [nucleotide binding]; DNA binding site 550538015703 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 9.9e-18 550538015704 malate dehydrogenase; Provisional; Region: PRK05086 550538015705 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 550538015706 NAD binding site [chemical binding]; other site 550538015707 dimerization interface [polypeptide binding]; other site 550538015708 Substrate binding site [chemical binding]; other site 550538015709 HMMPfam hit to PF02866, Lactate/malate dehydrogenase, score 1.2e-72 550538015710 PS00068 Malate dehydrogenase active site signature. 550538015711 HMMPfam hit to PF00056, Lactate/malate dehydrogenase, score 1.8e-71 550538015712 arginine repressor; Provisional; Region: PRK05066 550538015713 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 550538015714 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 550538015715 HMMPfam hit to PF01316, Arginine repressor, score 4.6e-32 550538015716 HMMPfam hit to PF02863, Arginine repressor, score 1.4e-25 550538015717 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538015718 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 6.3e-57 550538015719 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538015720 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 2.4e-54 550538015721 1 probable transmembrane helix predicted for SG3252 by TMHMM2.0 at aa 5-24 550538015722 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 550538015723 RNAase interaction site [polypeptide binding]; other site 550538015724 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 550538015725 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 550538015726 10 probable transmembrane helices predicted for SG3254 by TMHMM2.0 at aa 13-33, 38-60, 67-89, 93-112, 119-136, 151-168, 370-392, 407-426, 433-452 and 481-503 550538015727 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved region, score 5.2e-50 550538015728 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 550538015729 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538015730 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538015731 HMMPfam hit to PF00529, Secretion protein HlyD, score 5.1e-40 550538015732 1 probable transmembrane helix predicted for SG3255 by TMHMM2.0 at aa 12-31 550538015733 efflux system membrane protein; Provisional; Region: PRK11594 550538015734 2 probable transmembrane helices predicted for SG3256 by TMHMM2.0 at aa 7-29 and 44-66 550538015735 HMMPfam hit to PF07869, Protein of unknown function DUF1656, score 7.2e-23 550538015736 transcriptional regulator; Provisional; Region: PRK10632 550538015737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538015738 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 550538015739 putative effector binding pocket; other site 550538015740 dimerization interface [polypeptide binding]; other site 550538015741 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.8e-18 550538015742 PS00044 Bacterial regulatory proteins, lysR family signature. 550538015743 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-43 550538015744 protease TldD; Provisional; Region: tldD; PRK10735 550538015745 HMMPfam hit to PF01523, Peptidase U62, modulator of DNA gyrase, score 1.6e-112 550538015746 hypothetical protein; Provisional; Region: PRK10899 550538015747 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 550538015748 ribonuclease G; Provisional; Region: PRK11712 550538015749 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 550538015750 homodimer interface [polypeptide binding]; other site 550538015751 oligonucleotide binding site [chemical binding]; other site 550538015752 HMMPfam hit to PF00575, S1, RNA binding, score 1.2e-19 550538015753 Maf-like protein; Region: Maf; pfam02545 550538015754 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 550538015755 active site 550538015756 dimer interface [polypeptide binding]; other site 550538015757 HMMPfam hit to PF02545, Maf-like protein, score 3.9e-99 550538015758 rod shape-determining protein MreD; Provisional; Region: PRK11060 550538015759 HMMPfam hit to PF04093, Rod shape-determining protein MreD, score 1.8e-63 550538015760 5 probable transmembrane helices predicted for SG3262 by TMHMM2.0 at aa 11-28, 32-51, 58-80, 100-122 and 135-152 550538015761 rod shape-determining protein MreC; Region: mreC; TIGR00219 550538015762 rod shape-determining protein MreC; Region: MreC; pfam04085 550538015763 HMMPfam hit to PF04085, Rod shape-determining protein MreC, score 1.3e-72 550538015764 1 probable transmembrane helix predicted for SG3263 by TMHMM2.0 at aa 13-35 550538015765 rod shape-determining protein MreB; Provisional; Region: PRK13927 550538015766 MreB and similar proteins; Region: MreB_like; cd10225 550538015767 nucleotide binding site [chemical binding]; other site 550538015768 Mg binding site [ion binding]; other site 550538015769 putative protofilament interaction site [polypeptide binding]; other site 550538015770 RodZ interaction site [polypeptide binding]; other site 550538015771 HMMPfam hit to PF06723, Cell shape determining protein MreB/Mrl, score 7.8e-239 550538015772 regulatory protein CsrD; Provisional; Region: PRK11059 550538015773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538015774 metal binding site [ion binding]; metal-binding site 550538015775 active site 550538015776 I-site; other site 550538015777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538015778 HMMPfam hit to PF00563, EAL, score 2.4e-58 550538015779 HMMPfam hit to PF00990, GGDEF, score 1.6e-31 550538015780 2 probable transmembrane helices predicted for SG3266 by TMHMM2.0 at aa 10-32 and 130-152 550538015781 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538015782 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 550538015783 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 550538015784 NADP binding site [chemical binding]; other site 550538015785 dimer interface [polypeptide binding]; other site 550538015786 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 4.2e-10 550538015787 PS00213 Lipocalin signature. 550538015788 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538015789 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 8e-14 550538015790 TMAO/DMSO reductase; Reviewed; Region: PRK05363 550538015791 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 550538015792 Moco binding site; other site 550538015793 metal coordination site [ion binding]; other site 550538015794 HMMPfam hit to PF00174, Oxidoreductase, molybdopterin binding, score 7e-68 550538015795 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 550538015796 6 probable transmembrane helices predicted for SG3269 by TMHMM2.0 at aa 13-30, 45-67, 80-102, 117-139, 151-168 and 172-189 550538015797 HMMPfam hit to PF01794, Ferric reductase-like transmembrane component, N-terminal, score 3.1e-29 550538015798 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 550538015799 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 550538015800 carboxyltransferase (CT) interaction site; other site 550538015801 biotinylation site [posttranslational modification]; other site 550538015802 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2.5e-35 550538015803 PS00188 Biotin-requiring enzymes attachment site. 550538015804 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 550538015805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 550538015806 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 550538015807 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 550538015808 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 1.3e-56 550538015809 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 1.2e-129 550538015810 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 550538015811 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 550538015812 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 1.8e-65 550538015813 hypothetical protein; Provisional; Region: PRK10633 550538015814 HMMPfam hit to PF06196, Protein of unknown function DUF997, score 3e-44 550538015815 2 probable transmembrane helices predicted for SG3272 by TMHMM2.0 at aa 13-32 and 42-64 550538015816 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 550538015817 Na binding site [ion binding]; other site 550538015818 13 probable transmembrane helices predicted for SG3273 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 189-211, 233-255, 268-290, 319-341, 369-386, 391-413, 420-442 and 447-466 550538015819 HMMPfam hit to PF00474, Na+/solute symporter, score 4.1e-197 550538015820 PS00456 Sodium:solute symporter family signature 1. 550538015821 PS00457 Sodium:solute symporter family signature 2. 550538015822 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 550538015823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 550538015824 HMMPfam hit to PF06325, Ribosomal L11 methyltransferase, score 1.7e-175 550538015825 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015826 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 550538015827 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 550538015828 FMN binding site [chemical binding]; other site 550538015829 active site 550538015830 catalytic residues [active] 550538015831 substrate binding site [chemical binding]; other site 550538015832 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 6.6e-159 550538015833 PS01136 Uncharacterized protein family UPF0034 signature. 550538015834 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 550538015835 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 550538015836 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.1e-14 550538015837 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 550538015838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538015839 DNA methylase; Region: N6_N4_Mtase; pfam01555 550538015840 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 7e-79 550538015841 PS00092 N-6 Adenine-specific DNA methylases signature. 550538015842 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 550538015843 1 probable transmembrane helix predicted for SG3278 by TMHMM2.0 at aa 7-29 550538015844 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 550538015845 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 550538015846 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 550538015847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538015848 metal binding site [ion binding]; metal-binding site 550538015849 active site 550538015850 I-site; other site 550538015851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538015852 7 probable transmembrane helices predicted for SG3279 by TMHMM2.0 at aa 10-27, 40-62, 77-99, 112-134, 139-161, 174-193 and 213-235 550538015853 HMMPfam hit to PF03707, MHYT, score 2.4e-17 550538015854 HMMPfam hit to PF03707, MHYT, score 4.9e-16 550538015855 HMMPfam hit to PF03707, MHYT, score 3.9e-06 550538015856 HMMPfam hit to PF00990, GGDEF, score 1.2e-58 550538015857 HMMPfam hit to PF00563, EAL, score 6.4e-121 550538015858 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 550538015859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538015860 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 550538015861 HMMPfam hit to PF08361, Transcriptional regulator, MAATS, C-terminal, score 1.2e-74 550538015862 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 1.3e-20 550538015863 PS01081 Bacterial regulatory proteins, tetR family signature. 550538015864 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 550538015865 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538015866 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538015867 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538015868 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.8e-96 550538015870 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 550538015871 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 550538015872 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538015873 1 probable transmembrane helix predicted for SG3284 by TMHMM2.0 at aa 50-72 550538015874 glutamate racemase; Provisional; Region: PRK00865 550538015875 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 5.5e-91 550538015876 PS00924 Aspartate and glutamate racemases signature 2. 550538015877 PS00923 Aspartate and glutamate racemases signature 1. 550538015878 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 550538015879 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 550538015880 N-terminal plug; other site 550538015881 ligand-binding site [chemical binding]; other site 550538015882 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 5.4e-27 550538015883 PS01156 TonB-dependent receptor proteins signature 2. 550538015884 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.1e-27 550538015885 PS00430 TonB-dependent receptor proteins signature 1. 550538015886 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 550538015887 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 550538015888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538015889 S-adenosylmethionine binding site [chemical binding]; other site 550538015890 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 1.5e-286 550538015891 PS01230 RNA methyltransferase trmA family signature 1. 550538015892 PS01231 RNA methyltransferase trmA family signature 2. 550538015893 hypothetical protein; Provisional; Region: PRK11056 550538015894 HMMPfam hit to PF07226, Protein of unknown function DUF1422, score 2.9e-78 550538015895 3 probable transmembrane helices predicted for SG3288 by TMHMM2.0 at aa 25-47, 60-82 and 86-108 550538015896 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 550538015897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538015898 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 7.7e-13 550538015899 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 550538015900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538015901 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 550538015902 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.1e-44 550538015903 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.4e-27 550538015904 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 4.2e-39 550538015905 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 550538015906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538015907 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 550538015908 dimerization interface [polypeptide binding]; other site 550538015909 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.6e-59 550538015910 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.4e-21 550538015911 PS00044 Bacterial regulatory proteins, lysR family signature. 550538015912 argininosuccinate lyase; Provisional; Region: PRK04833 550538015913 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 550538015914 active sites [active] 550538015915 tetramer interface [polypeptide binding]; other site 550538015916 HMMPfam hit to PF00206, Fumarate lyase, score 1e-146 550538015917 PS00163 Fumarate lyases signature. 550538015918 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 550538015919 nucleotide binding site [chemical binding]; other site 550538015920 N-acetyl-L-glutamate binding site [chemical binding]; other site 550538015921 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 3.8e-43 550538015922 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 550538015923 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 550538015924 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 2.1e-39 550538015925 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 2.1e-60 550538015926 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538015927 acetylornithine deacetylase; Provisional; Region: PRK05111 550538015928 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 550538015929 metal binding site [ion binding]; metal-binding site 550538015930 putative dimer interface [polypeptide binding]; other site 550538015931 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 550538015932 HMMPfam hit to PF01546, Peptidase M20, score 7.8e-43 550538015933 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 550538015934 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 2.3e-33 550538015935 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 550538015936 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 550538015937 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 1.1e-225 550538015938 PS00781 Phosphoenolpyruvate carboxylase active site 1. 550538015939 PS00393 Phosphoenolpyruvate carboxylase active site 2. 550538015941 HMMPfam hit to PF00884, Sulphatase, score 7.1e-73 550538015942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 550538015943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538015944 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.6e-07 550538015945 PS00041 Bacterial regulatory proteins, araC family signature. 550538015946 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.6e-14 550538015947 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 550538015948 active site 550538015949 P-loop; other site 550538015950 phosphorylation site [posttranslational modification] 550538015951 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 5.3e-52 550538015952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538015953 FeS/SAM binding site; other site 550538015954 pyruvate formate lyase II activase; Provisional; Region: PRK10076 550538015955 HMMPfam hit to PF04055, Radical SAM, score 4.3e-15 550538015956 PS01087 Radical activating enzymes signature. 550538015957 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 550538015958 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 550538015959 dimer interface [polypeptide binding]; other site 550538015960 active site 550538015961 glycine loop; other site 550538015962 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 2.3e-43 550538015963 PS00850 Glycine radical signature. 550538015964 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 2e-298 550538015965 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 550538015966 active site 550538015967 P-loop; other site 550538015968 phosphorylation site [posttranslational modification] 550538015969 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 5.1e-62 550538015970 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 550538015971 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 550538015972 8 probable transmembrane helices predicted for SG3305 by TMHMM2.0 at aa 21-40, 60-82, 95-117, 132-154, 175-194, 214-236, 273-295 and 315-334 550538015973 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.2e-05 550538015974 the sequence has been checked and is believed to be correct 550538015975 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 0.00028 550538015976 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 0.00012 550538015977 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 7.7e-24 550538015978 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 1.4e-167 550538015979 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 1.3e-08 550538015980 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 550538015981 active site 550538015982 intersubunit interactions; other site 550538015983 catalytic residue [active] 550538015984 HMMPfam hit to PF00923, Transaldolase, score 1.1e-92 550538015985 PS01054 Transaldolase signature 1. 550538015986 PS00958 Transaldolase active site. 550538015987 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 550538015988 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 550538015989 dimer interface [polypeptide binding]; other site 550538015990 active site 550538015991 metal binding site [ion binding]; metal-binding site 550538015992 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.2e-87 550538015993 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538015994 PS00060 Iron-containing alcohol dehydrogenases signature 2. 550538015995 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538015996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 550538015997 HMMPfam hit to PF06940, Protein of unknown function DUF1287, score 1.9e-145 550538015998 PS00017 ATP/GTP-binding site motif A (P-loop). 550538015999 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 550538016000 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 550538016001 heme binding site [chemical binding]; other site 550538016002 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 550538016003 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 6.3e-106 550538016004 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 7.8e-85 550538016005 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016006 PS00435 Peroxidases proximal heme-ligand signature. 550538016007 PS00436 Peroxidases active site signature. 550538016008 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 550538016009 FAD binding site [chemical binding]; other site 550538016010 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 1.8e-158 550538016011 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 550538016012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538016013 DNA-binding site [nucleotide binding]; DNA binding site 550538016014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538016015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538016016 homodimer interface [polypeptide binding]; other site 550538016017 catalytic residue [active] 550538016018 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 6e-13 550538016019 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 9.2e-07 550538016020 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 550538016021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 550538016022 active site 550538016023 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538016024 dimer interface [polypeptide binding]; other site 550538016025 substrate binding site [chemical binding]; other site 550538016026 catalytic residues [active] 550538016027 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 1.1e-41 550538016028 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.4e-34 550538016029 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 550538016030 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 550538016031 dimer interface [polypeptide binding]; other site 550538016032 active site 550538016033 glycine-pyridoxal phosphate binding site [chemical binding]; other site 550538016034 folate binding site [chemical binding]; other site 550538016035 HMMPfam hit to PF00464, Glycine hydroxymethyltransferase, score 5.9e-239 550538016036 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 550538016037 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538016038 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 550538016039 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 550538016040 active site 550538016041 metal binding site [ion binding]; metal-binding site 550538016042 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 550538016043 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 1.5e-51 550538016044 HMMPfam hit to PF00149, Metallophosphoesterase, score 7.2e-12 550538016045 PS00786 5'-nucleotidase signature 2. 550538016046 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 550538016047 9 probable transmembrane helices predicted for SG3317 by TMHMM2.0 at aa 21-40, 60-82, 89-111, 121-143, 148-170, 175-194, 215-237, 252-274 and 295-314 550538016048 mechanosensitive channel MscS; Provisional; Region: PRK10334 550538016049 Conserved TM helix; Region: TM_helix; pfam05552 550538016050 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538016051 HMMPfam hit to PF05552, Conserved TM helix, score 2.2e-17 550538016052 3 probable transmembrane helices predicted for SG3318 by TMHMM2.0 at aa 23-45, 65-87 and 97-119 550538016053 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.8e-72 550538016054 PS01246 Uncharacterized protein family UPF0003 signature. 550538016055 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 550538016056 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 550538016057 putative catalytic residues [active] 550538016058 putative nucleotide binding site [chemical binding]; other site 550538016059 putative aspartate binding site [chemical binding]; other site 550538016060 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 550538016061 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 550538016062 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 550538016063 HMMPfam hit to PF00742, Homoserine dehydrogenase, catalytic, score 3.1e-104 550538016064 PS01042 Homoserine dehydrogenase signature. 550538016065 HMMPfam hit to PF03447, Aspartate/homoserine dehydrogenase, NAD-binding, score 4.3e-43 550538016066 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 4.7e-49 550538016067 PS00324 Aspartokinase signature. 550538016068 cystathionine gamma-synthase; Provisional; Region: PRK08045 550538016069 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 550538016070 homodimer interface [polypeptide binding]; other site 550538016071 substrate-cofactor binding pocket; other site 550538016072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538016073 catalytic residue [active] 550538016074 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 4.1e-222 550538016075 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 550538016076 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 550538016077 dimerization interface [polypeptide binding]; other site 550538016078 DNA binding site [nucleotide binding] 550538016079 corepressor binding sites; other site 550538016080 HMMPfam hit to PF01340, Methionine repressor MetJ, score 5.8e-89 550538016081 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 550538016082 1 probable transmembrane helix predicted for SG3322 by TMHMM2.0 at aa 7-26 550538016083 HMMPfam hit to PF05935, Arylsulphotransferase, score 0 550538016084 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 550538016085 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538016086 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 550538016087 HMMPfam hit to PF01197, Ribosomal protein L31, score 2e-43 550538016088 PS01143 Ribosomal protein L31 signature. 550538016089 PS00190 Cytochrome c family heme-binding site signature. 550538016090 primosome assembly protein PriA; Validated; Region: PRK05580 550538016091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538016092 ATP binding site [chemical binding]; other site 550538016093 putative Mg++ binding site [ion binding]; other site 550538016094 helicase superfamily c-terminal domain; Region: HELICc; smart00490 550538016095 ATP-binding site [chemical binding]; other site 550538016096 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 7.6e-33 550538016097 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016098 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 5.4e-08 550538016099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538016100 DNA binding site [nucleotide binding] 550538016101 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 550538016102 domain linker motif; other site 550538016103 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 550538016104 dimerization interface [polypeptide binding]; other site 550538016105 ligand binding site [chemical binding]; other site 550538016106 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 9.2e-12 550538016107 PS00356 Bacterial regulatory proteins, lacI family signature. 550538016108 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.4e-28 550538016109 essential cell division protein FtsN; Provisional; Region: PRK10927 550538016110 cell division protein FtsN; Provisional; Region: PRK12757 550538016111 1 probable transmembrane helix predicted for SG3327 by TMHMM2.0 at aa 35-57 550538016112 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 1.4e-19 550538016113 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 550538016114 active site 550538016115 HslU subunit interaction site [polypeptide binding]; other site 550538016116 HMMPfam hit to PF00227, 20S proteasome, A and B subunits, score 4.5e-36 550538016117 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 550538016118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538016119 Walker A motif; other site 550538016120 ATP binding site [chemical binding]; other site 550538016121 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 550538016122 Walker B motif; other site 550538016123 arginine finger; other site 550538016124 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 550538016125 HMMPfam hit to PF07724, ATPase AAA-2, score 8.3e-14 550538016126 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016127 HMMPfam hit to PF07724, ATPase AAA-2, score 4e-56 550538016128 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 550538016129 UbiA prenyltransferase family; Region: UbiA; pfam01040 550538016130 9 probable transmembrane helices predicted for SG3330 by TMHMM2.0 at aa 21-40, 45-64, 99-121, 125-144, 151-173, 178-200, 230-249, 253-270 and 291-308 550538016131 HMMPfam hit to PF01040, UbiA prenyltransferase, score 3.2e-47 550538016132 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 550538016133 HMMPfam hit to PF03737, Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase, score 2.9e-77 550538016134 septal ring assembly protein ZapB; Provisional; Region: PRK15422 550538016135 HMMPfam hit to PF06005, Protein of unknown function DUF904, score 3.8e-43 550538016136 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 550538016137 amphipathic channel; other site 550538016138 Asn-Pro-Ala signature motifs; other site 550538016139 HMMPfam hit to PF00230, Major intrinsic protein, score 1.2e-120 550538016140 6 probable transmembrane helices predicted for SG3333 by TMHMM2.0 at aa 12-34, 44-66, 86-108, 145-167, 180-202 and 232-251 550538016141 PS00221 MIP family signature. 550538016142 glycerol kinase; Provisional; Region: glpK; PRK00047 550538016143 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 550538016144 N- and C-terminal domain interface [polypeptide binding]; other site 550538016145 active site 550538016146 MgATP binding site [chemical binding]; other site 550538016147 catalytic site [active] 550538016148 metal binding site [ion binding]; metal-binding site 550538016149 glycerol binding site [chemical binding]; other site 550538016150 homotetramer interface [polypeptide binding]; other site 550538016151 homodimer interface [polypeptide binding]; other site 550538016152 FBP binding site [chemical binding]; other site 550538016153 protein IIAGlc interface [polypeptide binding]; other site 550538016154 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 4.4e-136 550538016155 PS00933 FGGY family of carbohydrate kinases signature 1. 550538016156 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 3.6e-112 550538016157 PS00445 FGGY family of carbohydrate kinases signature 2. 550538016158 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 550538016159 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 550538016160 putative active site [active] 550538016161 HMMPfam hit to PF03320, GlpX, score 3.8e-243 550538016162 ferredoxin-NADP reductase; Provisional; Region: PRK10926 550538016163 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 550538016164 FAD binding pocket [chemical binding]; other site 550538016165 FAD binding motif [chemical binding]; other site 550538016166 phosphate binding motif [ion binding]; other site 550538016167 beta-alpha-beta structure motif; other site 550538016168 NAD binding pocket [chemical binding]; other site 550538016169 PS00430 TonB-dependent receptor proteins signature 1. 550538016170 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 0.00016 550538016171 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 3.7e-18 550538016172 Predicted membrane protein [Function unknown]; Region: COG3152 550538016173 HMMPfam hit to PF05656, Protein of unknown function DUF805, score 9.3e-50 550538016174 4 probable transmembrane helices predicted for SG3337 by TMHMM2.0 at aa 20-37, 41-63, 75-97 and 101-123 550538016175 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 550538016176 HMMPfam hit to PF07305, Protein of unknown function DUF1454, score 1.8e-139 550538016177 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 550538016178 triosephosphate isomerase; Provisional; Region: PRK14567 550538016179 substrate binding site [chemical binding]; other site 550538016180 dimer interface [polypeptide binding]; other site 550538016181 catalytic triad [active] 550538016182 HMMPfam hit to PF00121, Triosephosphate isomerase, score 6e-134 550538016183 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016184 PS00171 Triosephosphate isomerase active site. 550538016185 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 550538016186 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 550538016187 substrate binding site [chemical binding]; other site 550538016188 hexamer interface [polypeptide binding]; other site 550538016189 metal binding site [ion binding]; metal-binding site 550538016190 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 2e-12 550538016191 1 probable transmembrane helix predicted for SG3340 by TMHMM2.0 at aa 12-34 550538016192 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 550538016193 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 1.1e-18 550538016194 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 550538016195 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 550538016196 putative active site; other site 550538016197 catalytic residue [active] 550538016198 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 4.3e-16 550538016199 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538016200 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 550538016201 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 550538016202 ligand binding site [chemical binding]; other site 550538016203 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 550538016204 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 550538016205 TM-ABC transporter signature motif; other site 550538016206 9 probable transmembrane helices predicted for SG3344 by TMHMM2.0 at aa 7-29, 39-61, 66-88, 92-114, 119-141, 161-183, 214-236, 251-282 and 295-314 550538016207 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 3.6e-68 550538016208 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 550538016209 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 550538016210 TM-ABC transporter signature motif; other site 550538016211 9 probable transmembrane helices predicted for SG3345 by TMHMM2.0 at aa 13-32, 36-58, 65-87, 91-113, 118-135, 155-177, 210-232, 250-272 and 279-301 550538016212 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 9.2e-52 550538016213 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 550538016214 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 550538016215 Walker A/P-loop; other site 550538016216 ATP binding site [chemical binding]; other site 550538016217 Q-loop/lid; other site 550538016218 ABC transporter signature motif; other site 550538016219 Walker B; other site 550538016220 D-loop; other site 550538016221 H-loop/switch region; other site 550538016222 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 550538016223 HMMPfam hit to PF00005, ABC transporter related, score 2.8e-28 550538016224 PS00211 ABC transporters family signature. 550538016225 HMMPfam hit to PF00005, ABC transporter related, score 3.1e-48 550538016226 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016227 transcriptional regulator LsrR; Provisional; Region: PRK15418 550538016228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 550538016229 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 550538016230 HMMPfam hit to PF04198, sugar-binding region, score 4.6e-85 550538016231 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 550538016232 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 550538016233 putative N- and C-terminal domain interface [polypeptide binding]; other site 550538016234 putative active site [active] 550538016235 putative MgATP binding site [chemical binding]; other site 550538016236 catalytic site [active] 550538016237 metal binding site [ion binding]; metal-binding site 550538016238 putative carbohydrate binding site [chemical binding]; other site 550538016239 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 550538016240 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1.1e-46 550538016241 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 1.1e-19 550538016242 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 550538016243 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.8e-19 550538016245 HMMPfam hit to PF02611, CDP-diacylglycerol pyrophosphatase, bacterial, score 3.6e-21 550538016246 1 probable transmembrane helix predicted for SG3351 by TMHMM2.0 at aa 20-42 550538016247 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 550538016248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538016249 DNA-binding site [nucleotide binding]; DNA binding site 550538016250 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 550538016251 UTRA domain; Region: UTRA; pfam07702 550538016252 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 2.1e-26 550538016253 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.2e-13 550538016254 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 550538016255 HMMPfam hit to PF03747, ADP-ribosylation/Crystallin J1, score 6.2e-33 550538016257 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.1e-69 550538016258 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 550538016259 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 550538016260 11 probable transmembrane helices predicted for SG3356 by TMHMM2.0 at aa 12-34, 44-66, 79-96, 106-128, 149-171, 176-198, 226-248, 263-285, 317-339, 365-387 and 400-422 550538016261 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5.6e-09 550538016262 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 550538016263 HMMPfam hit to PF02611, CDP-diacylglycerol pyrophosphatase, bacterial, score 2.4e-159 550538016264 1 probable transmembrane helix predicted for SG3357 by TMHMM2.0 at aa 5-23 550538016265 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 550538016266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538016267 substrate binding pocket [chemical binding]; other site 550538016268 membrane-bound complex binding site; other site 550538016269 hinge residues; other site 550538016270 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 2.8e-15 550538016271 PS00757 Prokaryotic sulfate-binding proteins signature 2. 550538016272 PS00401 Prokaryotic sulfate-binding proteins signature 1. 550538016273 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 550538016274 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 550538016275 active site 550538016276 ADP/pyrophosphate binding site [chemical binding]; other site 550538016277 dimerization interface [polypeptide binding]; other site 550538016278 allosteric effector site; other site 550538016279 fructose-1,6-bisphosphate binding site; other site 550538016280 HMMPfam hit to PF00365, Phosphofructokinase, score 2.1e-192 550538016281 PS00433 Phosphofructokinase signature. 550538016282 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 550538016283 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 550538016284 HMMPfam hit to PF01545, Cation efflux protein, score 1.8e-109 550538016285 6 probable transmembrane helices predicted for SG3360 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139, 158-175 and 180-199 550538016286 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 550538016287 dimer interface [polypeptide binding]; other site 550538016288 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.00033 550538016289 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.003 550538016290 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 550538016291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538016292 active site 550538016293 intermolecular recognition site; other site 550538016294 dimerization interface [polypeptide binding]; other site 550538016295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538016296 DNA binding site [nucleotide binding] 550538016297 HMMPfam hit to PF00072, Response regulator receiver, score 2.7e-42 550538016298 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.7e-22 550538016299 two-component sensor protein; Provisional; Region: cpxA; PRK09470 550538016300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538016301 dimerization interface [polypeptide binding]; other site 550538016302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538016303 dimer interface [polypeptide binding]; other site 550538016304 phosphorylation site [posttranslational modification] 550538016305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538016306 ATP binding site [chemical binding]; other site 550538016307 Mg2+ binding site [ion binding]; other site 550538016308 G-X-G motif; other site 550538016309 2 probable transmembrane helices predicted for SG3363 by TMHMM2.0 at aa 5-27 and 165-187 550538016310 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 9.8e-14 550538016311 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.4e-17 550538016312 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 9.1e-39 550538016313 SnoaL-like domain; Region: SnoaL_2; pfam12680 550538016314 the sequence has been checked and is believed to be correct 550538016315 HMMPfam hit to PF03475, Protein of unknown function 3-alpha region, score 5.4e-13 550538016316 HMMPfam hit to PF03473, Molybdenum cofactor sulphurase, C-terminal, score 5.2e-38 550538016317 superoxide dismutase; Provisional; Region: PRK10925 550538016318 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 550538016319 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 550538016320 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 7.6e-70 550538016321 PS00088 Manganese and iron superoxide dismutases signature. 550538016322 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 1.5e-53 550538016323 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 550538016324 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 550538016325 HMMPfam hit to PF03480, TRAP dicarboxylate transporter- DctP subunit, score 3.5e-78 550538016326 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 550538016327 4 probable transmembrane helices predicted for SG3368 by TMHMM2.0 at aa 10-32, 48-66, 86-108 and 129-151 550538016328 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538016329 HMMPfam hit to PF04290, Tripartite ATP-independent periplasmic transporter, DctQ component, score 2.8e-33 550538016330 DctM-like transporters; Region: DctM; pfam06808 550538016331 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 550538016332 12 probable transmembrane helices predicted for SG3369 by TMHMM2.0 at aa 10-41, 61-83, 103-125, 146-168, 178-200, 221-243, 248-267, 280-302, 312-334, 341-360, 370-392 and 404-426 550538016333 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport system permease DctM subunit, score 4.5e-187 550538016334 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 550538016335 HMMPfam hit to PF06178, Oligogalacturonate-specific porin, score 6.2e-117 550538016336 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 550538016337 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 550538016338 HMMPfam hit to PF06379, RhaT l-rhamnose-proton symport 2, score 1.2e-296 550538016339 10 probable transmembrane helices predicted for SG3371 by TMHMM2.0 at aa 4-26, 38-55, 70-92, 99-121, 136-155, 175-192, 212-234, 254-276, 291-309 and 321-343 550538016340 the sequence has been checked and is believed to be correct 550538016341 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.8e-13 550538016342 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 1.1e-21 550538016343 transcriptional activator RhaS; Provisional; Region: PRK13503 550538016344 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 550538016345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538016346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538016347 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.9e-14 550538016348 PS00041 Bacterial regulatory proteins, araC family signature. 550538016349 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.5e-07 550538016350 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 8.9e-26 550538016351 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 550538016352 N- and C-terminal domain interface [polypeptide binding]; other site 550538016353 active site 550538016354 putative catalytic site [active] 550538016355 metal binding site [ion binding]; metal-binding site 550538016356 ATP binding site [chemical binding]; other site 550538016357 rhamnulokinase; Provisional; Region: rhaB; PRK10640 550538016358 carbohydrate binding site [chemical binding]; other site 550538016359 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 4.5e-15 550538016360 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016361 L-rhamnose isomerase; Provisional; Region: PRK01076 550538016362 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 550538016363 HMMPfam hit to PF06134, Rhamnose isomerase, score 0 550538016364 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 550538016365 intersubunit interface [polypeptide binding]; other site 550538016366 active site 550538016367 Zn2+ binding site [ion binding]; other site 550538016368 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 2.1e-29 550538016370 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 5.2e-152 550538016371 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 550538016372 HMMPfam hit to PF05336, Rhamnose mutarotase, score 6.8e-58 550538016373 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 550538016374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538016375 non-specific DNA binding site [nucleotide binding]; other site 550538016376 salt bridge; other site 550538016377 sequence-specific DNA binding site [nucleotide binding]; other site 550538016378 Cupin domain; Region: Cupin_2; cl17218 550538016379 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 6.5e-13 550538016380 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 550538016381 HMMPfam hit to PF03591, AzlC-like, score 1.6e-42 550538016382 5 probable transmembrane helices predicted for SG3381 by TMHMM2.0 at aa 21-43, 58-80, 127-149, 159-178 and 191-213 550538016383 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 550538016384 4 probable transmembrane helices predicted for SG3382 by TMHMM2.0 at aa 4-26, 38-60, 65-82 and 87-106 550538016385 HMMPfam hit to PF05437, Branched-chain amino acid transport, score 3.9e-18 550538016386 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 550538016388 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 550538016389 HMMPfam hit to PF02634, Formate dehydrogenase, subunit FdhD, score 1.8e-140 550538016390 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 550538016391 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 550538016392 [4Fe-4S] binding site [ion binding]; other site 550538016393 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 550538016394 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 550538016395 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 550538016396 molybdopterin cofactor binding site; other site 550538016397 1 probable transmembrane helix predicted for SG3387 by TMHMM2.0 at aa 11-33 550538016398 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 5e-22 550538016399 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538016400 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4e-35 550538016401 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 2e-17 550538016402 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 550538016403 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 550538016404 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.2e-05 550538016405 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538016406 HMMPfam hit to PF09163, Formate dehydrogenase, transmembrane, score 6.2e-25 550538016407 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 550538016408 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 550538016409 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 0.00041 550538016410 4 probable transmembrane helices predicted for SG3389 by TMHMM2.0 at aa 21-40, 55-77, 114-136 and 151-173 550538016411 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 550538016412 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 550538016413 HMMPfam hit to PF04216, Formate dehydrogenase accessory protein, score 1.6e-207 550538016414 Predicted transcriptional regulator [Transcription]; Region: COG2944 550538016415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538016416 non-specific DNA binding site [nucleotide binding]; other site 550538016417 salt bridge; other site 550538016418 sequence-specific DNA binding site [nucleotide binding]; other site 550538016419 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.5e-08 550538016420 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 550538016421 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 550538016422 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 550538016423 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 4.5e-93 550538016424 PS01174 Lipolytic enzymes family, serine active site. 550538016425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 550538016426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538016427 non-specific DNA binding site [nucleotide binding]; other site 550538016428 salt bridge; other site 550538016429 sequence-specific DNA binding site [nucleotide binding]; other site 550538016430 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.1e-09 550538016431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538016432 Coenzyme A binding pocket [chemical binding]; other site 550538016433 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 550538016434 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.2e-16 550538016435 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 550538016436 putative active site [active] 550538016437 dimerization interface [polypeptide binding]; other site 550538016438 putative tRNAtyr binding site [nucleotide binding]; other site 550538016439 HMMPfam hit to PF02580, D-tyrosyl-tRNA(Tyr) deacylase, score 8.5e-92 550538016440 hypothetical protein; Reviewed; Region: PRK01637 550538016441 HMMPfam hit to PF03631, Ribonuclease BN, score 7.8e-77 550538016442 6 probable transmembrane helices predicted for SG3398 by TMHMM2.0 at aa 39-61, 101-120, 141-163, 183-200, 212-234 and 244-266 550538016443 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 550538016444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538016445 motif II; other site 550538016446 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.4e-16 550538016447 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538016448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538016449 putative DNA binding site [nucleotide binding]; other site 550538016450 putative Zn2+ binding site [ion binding]; other site 550538016451 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538016452 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 4.1e-77 550538016453 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2e-25 550538016454 PS00894 Bacterial regulatory proteins, deoR family signature. 550538016455 the sequence has been checked and is believed to be correct 550538016456 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1e-65 550538016457 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 550538016458 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 550538016459 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 1.7e-65 550538016460 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 550538016461 the sequence has been checked and is believed to be correct 550538016462 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 3.2e-79 550538016463 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 550538016464 dimerization interface [polypeptide binding]; other site 550538016465 putative active cleft [active] 550538016466 HMMPfam hit to PF07221, N-acylglucosamine 2-epimerase, score 3.5e-194 550538016467 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 550538016468 active site 550538016469 catalytic residues [active] 550538016470 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016471 HMMPfam hit to PF01263, Aldose 1-epimerase, score 4.8e-64 550538016472 alpha-glucosidase; Provisional; Region: PRK10426 550538016473 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 550538016474 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 550538016475 putative active site [active] 550538016476 putative catalytic site [active] 550538016477 HMMPfam hit to PF01055, Glycoside hydrolase, family 31, score 3.3e-114 550538016478 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 550538016479 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 550538016480 11 probable transmembrane helices predicted for SG3407 by TMHMM2.0 at aa 46-68, 89-111, 121-143, 156-178, 188-210, 244-266, 276-295, 308-328, 333-355, 387-409 and 419-441 550538016481 PS00872 Sodium:galactoside symporter family signature. 550538016482 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 550538016483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538016484 putative substrate translocation pore; other site 550538016485 12 probable transmembrane helices predicted for SG3408 by TMHMM2.0 at aa 20-42, 52-74, 86-108, 119-141, 154-176, 186-208, 237-259, 274-296, 303-325, 329-351, 380-402 and 415-437 550538016486 PS00872 Sodium:galactoside symporter family signature. 550538016487 outer membrane porin L; Provisional; Region: ompL; PRK09980 550538016488 HMMPfam hit to PF06178, Oligogalacturonate-specific porin, score 1.7e-116 550538016489 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 550538016490 Sulfatase; Region: Sulfatase; cl17466 550538016491 coproporphyrinogen III oxidase; Validated; Region: PRK08208 550538016492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538016493 FeS/SAM binding site; other site 550538016494 HemN C-terminal domain; Region: HemN_C; pfam06969 550538016495 HMMPfam hit to PF04055, Radical SAM, score 6e-19 550538016496 HMMPfam hit to PF06969, HemN, C-terminal, score 4.5e-06 550538016497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538016498 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 550538016499 active site 550538016500 motif I; other site 550538016501 motif II; other site 550538016502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538016503 PS01228 Hypothetical cof family signature 1. 550538016504 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 4.8e-85 550538016505 PS01229 Hypothetical cof family signature 2. 550538016506 GTP-binding protein; Provisional; Region: PRK10218 550538016507 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 550538016508 G1 box; other site 550538016509 putative GEF interaction site [polypeptide binding]; other site 550538016510 GTP/Mg2+ binding site [chemical binding]; other site 550538016511 Switch I region; other site 550538016512 G2 box; other site 550538016513 G3 box; other site 550538016514 Switch II region; other site 550538016515 G4 box; other site 550538016516 G5 box; other site 550538016517 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 550538016518 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 550538016519 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 1.8e-19 550538016520 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3.4e-14 550538016521 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 3.5e-74 550538016522 PS00301 GTP-binding elongation factors signature. 550538016523 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016524 glutamine synthetase; Provisional; Region: glnA; PRK09469 550538016525 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 550538016526 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 550538016527 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp, score 1.3e-49 550538016528 PS00180 Glutamine synthetase signature 1. 550538016529 HMMPfam hit to PF00120, Glutamine synthetase, catalytic region, score 1.5e-179 550538016530 PS00181 Glutamine synthetase ATP-binding region signature. 550538016531 PS00182 Glutamine synthetase class-I adenylation site. 550538016532 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 550538016533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 550538016534 putative active site [active] 550538016535 heme pocket [chemical binding]; other site 550538016536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538016537 dimer interface [polypeptide binding]; other site 550538016538 phosphorylation site [posttranslational modification] 550538016539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538016540 ATP binding site [chemical binding]; other site 550538016541 Mg2+ binding site [ion binding]; other site 550538016542 G-X-G motif; other site 550538016543 HMMPfam hit to PF08448, PAS fold-4, score 0.00012 550538016544 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.5e-14 550538016545 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.7e-32 550538016546 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 550538016547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538016548 active site 550538016549 phosphorylation site [posttranslational modification] 550538016550 intermolecular recognition site; other site 550538016551 dimerization interface [polypeptide binding]; other site 550538016552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538016553 Walker A motif; other site 550538016554 ATP binding site [chemical binding]; other site 550538016555 Walker B motif; other site 550538016556 arginine finger; other site 550538016557 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 550538016558 HMMPfam hit to PF00072, Response regulator receiver, score 5.1e-43 550538016559 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 4.7e-147 550538016560 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538016561 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538016562 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538016563 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 9.5e-17 550538016564 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 550538016565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538016566 FeS/SAM binding site; other site 550538016567 HemN C-terminal domain; Region: HemN_C; pfam06969 550538016568 HMMPfam hit to PF06969, HemN, C-terminal, score 5.5e-54 550538016569 HMMPfam hit to PF04055, Radical SAM, score 2.7e-24 550538016571 HMMPfam hit to PF04220, Protein of unknown function DUF414, score 3.4e-82 550538016572 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 550538016573 G1 box; other site 550538016574 GTP/Mg2+ binding site [chemical binding]; other site 550538016575 Switch I region; other site 550538016576 G2 box; other site 550538016577 G3 box; other site 550538016578 Switch II region; other site 550538016579 G4 box; other site 550538016580 G5 box; other site 550538016581 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 3.6e-28 550538016582 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016583 DNA polymerase I; Provisional; Region: PRK05755 550538016584 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 550538016585 active site 550538016586 metal binding site 1 [ion binding]; metal-binding site 550538016587 putative 5' ssDNA interaction site; other site 550538016588 metal binding site 3; metal-binding site 550538016589 metal binding site 2 [ion binding]; metal-binding site 550538016590 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 550538016591 putative DNA binding site [nucleotide binding]; other site 550538016592 putative metal binding site [ion binding]; other site 550538016593 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 550538016594 active site 550538016595 catalytic site [active] 550538016596 substrate binding site [chemical binding]; other site 550538016597 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 550538016598 active site 550538016599 DNA binding site [nucleotide binding] 550538016600 catalytic site [active] 550538016601 HMMPfam hit to PF00476, DNA-directed DNA polymerase, score 2.9e-234 550538016602 PS00447 DNA polymerase family A signature. 550538016603 HMMPfam hit to PF01612, 3'-5' exonuclease, score 3.3e-70 550538016604 HMMPfam hit to PF01367, 5'-3' exonuclease, score 2.8e-53 550538016605 HMMPfam hit to PF02739, 5'-3' exonuclease, score 2.1e-94 550538016606 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 550538016607 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 550538016608 putative acyl-acceptor binding pocket; other site 550538016609 3 probable transmembrane helices predicted for SG3424 by TMHMM2.0 at aa 12-34, 49-66 and 122-140 550538016610 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 7e-32 550538016611 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 550538016612 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 550538016613 catalytic residues [active] 550538016614 hinge region; other site 550538016615 alpha helical domain; other site 550538016616 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.9e-55 550538016617 PS00194 Thioredoxin family active site. 550538016618 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 550538016619 serine/threonine protein kinase; Provisional; Region: PRK11768 550538016620 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 1.1e-40 550538016621 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 550538016622 HMMPfam hit to PF06288, Protein of unknown function DUF1040, score 6.4e-61 550538016623 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 550538016624 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 550538016625 GTP binding site; other site 550538016626 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 550538016627 Walker A motif; other site 550538016628 HMMPfam hit to PF03205, Molybdopterin-guanine dinucleotide biosynthesis MobB region, score 6e-57 550538016629 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016630 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 550538016631 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 550538016632 purine monophosphate binding site [chemical binding]; other site 550538016633 dimer interface [polypeptide binding]; other site 550538016634 putative catalytic residues [active] 550538016635 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 550538016636 HMMPfam hit to PF02142, MGS-like, score 1.5e-62 550538016637 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, formylation region, score 9.5e-224 550538016638 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 550538016639 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 550538016640 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 550538016641 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 550538016642 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, score 7.7e-65 550538016643 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, score 2.3e-138 550538016644 PS00184 Phosphoribosylglycinamide synthetase signature. 550538016645 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, score 7.8e-51 550538016646 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 550538016647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538016648 active site 550538016649 phosphorylation site [posttranslational modification] 550538016650 intermolecular recognition site; other site 550538016651 dimerization interface [polypeptide binding]; other site 550538016652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538016653 Walker A motif; other site 550538016654 ATP binding site [chemical binding]; other site 550538016655 Walker B motif; other site 550538016656 arginine finger; other site 550538016657 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 550538016658 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 8.8e-16 550538016659 PS00688 Sigma-54 interaction domain C-terminal part signature. 550538016660 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.5e-160 550538016661 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538016662 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538016663 HMMPfam hit to PF00072, Response regulator receiver, score 6.9e-49 550538016664 sensor protein ZraS; Provisional; Region: PRK10364 550538016665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538016666 dimer interface [polypeptide binding]; other site 550538016667 phosphorylation site [posttranslational modification] 550538016668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538016669 ATP binding site [chemical binding]; other site 550538016670 Mg2+ binding site [ion binding]; other site 550538016671 G-X-G motif; other site 550538016672 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.2e-39 550538016673 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.9e-16 550538016674 2 probable transmembrane helices predicted for SG3433 by TMHMM2.0 at aa 10-32 and 202-221 550538016675 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 550538016676 dimer interface [polypeptide binding]; other site 550538016677 1 probable transmembrane helix predicted for SG3434 by TMHMM2.0 at aa 7-29 550538016678 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 550538016679 HMMPfam hit to PF07356, Protein of unknown function DUF1481, score 2.8e-178 550538016680 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538016681 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 550538016682 IHF dimer interface [polypeptide binding]; other site 550538016683 IHF - DNA interface [nucleotide binding]; other site 550538016684 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 7e-51 550538016685 PS00045 Bacterial histone-like DNA-binding proteins signature. 550538016686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 550538016687 HMMPfam hit to PF04222, Protein of unknown function DUF416, score 1.6e-160 550538016688 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 550538016689 Active_site [active] 550538016690 HMMPfam hit to PF04493, Endonuclease V, score 1.3e-107 550538016691 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 550538016692 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 550538016693 substrate binding site [chemical binding]; other site 550538016694 active site 550538016695 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 9.5e-218 550538016696 PS00907 Uroporphyrinogen decarboxylase signature 2. 550538016697 PS00906 Uroporphyrinogen decarboxylase signature 1. 550538016698 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 550538016699 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 550538016700 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 550538016701 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 550538016702 putative NADH binding site [chemical binding]; other site 550538016703 putative active site [active] 550538016704 nudix motif; other site 550538016705 putative metal binding site [ion binding]; other site 550538016706 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.3e-30 550538016707 PS00893 mutT domain signature. 550538016708 HMMPfam hit to PF09297, Zinc ribbon, NADH pyrophosphatase, score 1.5e-14 550538016709 HMMPfam hit to PF09296, NADH pyrophosphatase-like, N-terminal, score 2.2e-12 550538016710 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 550538016711 HMMPfam hit to PF04353, Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ, score 4.8e-103 550538016712 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 550538016713 ThiC-associated domain; Region: ThiC-associated; pfam13667 550538016714 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 550538016715 HMMPfam hit to PF01964, Thiamine biosynthesis protein ThiC, score 0 550538016716 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 550538016717 thiamine phosphate binding site [chemical binding]; other site 550538016718 active site 550538016719 pyrophosphate binding site [ion binding]; other site 550538016720 HMMPfam hit to PF02581, Thiamine monophosphate synthase, score 1.6e-84 550538016721 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 550538016722 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 550538016723 ATP binding site [chemical binding]; other site 550538016724 substrate interface [chemical binding]; other site 550538016725 1 probable transmembrane helix predicted for SG3444 by TMHMM2.0 at aa 26-48 550538016726 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 3.6e-62 550538016727 HMMPfam hit to PF05237, MoeZ/MoeB, score 9.6e-38 550538016728 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 550538016729 thiS-thiF/thiG interaction site; other site 550538016730 HMMPfam hit to PF02597, ThiamineS, score 2.7e-17 550538016731 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 550538016732 ThiS interaction site; other site 550538016733 putative active site [active] 550538016734 tetramer interface [polypeptide binding]; other site 550538016735 HMMPfam hit to PF05690, Thiazole biosynthesis, score 2.8e-176 550538016736 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 550538016737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538016738 FeS/SAM binding site; other site 550538016739 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 550538016740 HMMPfam hit to PF04055, Radical SAM, score 1.2e-08 550538016741 HMMPfam hit to PF06968, Biotin and thiamin synthesis associated, score 9.9e-40 550538016743 3 probable transmembrane helices predicted for SG3452 by TMHMM2.0 at aa 20-42, 52-74 and 86-105 550538016744 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 550538016745 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 550538016746 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 550538016747 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 550538016748 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 550538016749 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 550538016750 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 550538016751 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 550538016752 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 550538016753 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 550538016754 DNA binding site [nucleotide binding] 550538016755 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 550538016756 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain 5, score 2.2e-110 550538016757 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain 4, score 7.2e-30 550538016758 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain 3, score 1.8e-54 550538016759 HMMPfam hit to PF00623, RNA polymerase, alpha subunit, score 2e-83 550538016760 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain 1, score 2.1e-169 550538016761 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 550538016762 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 550538016763 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 550538016764 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 550538016765 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 550538016766 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 550538016767 RPB3 interaction site [polypeptide binding]; other site 550538016768 RPB1 interaction site [polypeptide binding]; other site 550538016769 RPB11 interaction site [polypeptide binding]; other site 550538016770 RPB10 interaction site [polypeptide binding]; other site 550538016771 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain 7, score 4.2e-52 550538016772 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain 6, score 1.8e-187 550538016773 PS01166 RNA polymerases beta chain signature. 550538016774 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain 3, score 1.8e-43 550538016775 HMMPfam hit to PF04563, RNA polymerase, beta subunit, protrusion, score 4e-36 550538016776 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 4.3e-06 550538016777 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 550538016778 core dimer interface [polypeptide binding]; other site 550538016779 peripheral dimer interface [polypeptide binding]; other site 550538016780 L10 interface [polypeptide binding]; other site 550538016781 L11 interface [polypeptide binding]; other site 550538016782 putative EF-Tu interaction site [polypeptide binding]; other site 550538016783 putative EF-G interaction site [polypeptide binding]; other site 550538016784 HMMPfam hit to PF00542, Ribosomal protein L7/L12, C-terminal, score 1.6e-37 550538016785 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 550538016786 23S rRNA interface [nucleotide binding]; other site 550538016787 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 550538016788 HMMPfam hit to PF00466, Ribosomal protein L10, score 1.5e-36 550538016789 PS01109 Ribosomal protein L10 signature. 550538016790 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 550538016791 mRNA/rRNA interface [nucleotide binding]; other site 550538016792 HMMPfam hit to PF00687, Ribosomal protein L1, score 1.2e-134 550538016793 PS01199 Ribosomal protein L1 signature. 550538016794 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 550538016795 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 550538016796 23S rRNA interface [nucleotide binding]; other site 550538016797 L7/L12 interface [polypeptide binding]; other site 550538016798 putative thiostrepton binding site; other site 550538016799 L25 interface [polypeptide binding]; other site 550538016800 PS00359 Ribosomal protein L11 signature. 550538016801 HMMPfam hit to PF00298, Ribosomal protein L11, score 6.8e-39 550538016802 HMMPfam hit to PF03946, Ribosomal protein L11, score 2.1e-38 550538016803 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 550538016804 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 550538016805 putative homodimer interface [polypeptide binding]; other site 550538016806 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 550538016807 heterodimer interface [polypeptide binding]; other site 550538016808 homodimer interface [polypeptide binding]; other site 550538016809 PS01014 Transcription termination factor nusG signature. 550538016810 HMMPfam hit to PF00467, KOW, score 1.6e-11 550538016811 HMMPfam hit to PF02357, Transcription antitermination protein, NusG, N-terminal, score 1.6e-56 550538016812 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 550538016813 HMMPfam hit to PF00584, Protein secE/sec61-gamma protein, score 3.2e-26 550538016814 3 probable transmembrane helices predicted for SG3460 by TMHMM2.0 at aa 19-36, 40-62 and 94-116 550538016815 PS01067 Protein secE/sec61-gamma signature. 550538016816 elongation factor Tu; Reviewed; Region: PRK00049 550538016817 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 550538016818 G1 box; other site 550538016819 GEF interaction site [polypeptide binding]; other site 550538016820 GTP/Mg2+ binding site [chemical binding]; other site 550538016821 Switch I region; other site 550538016822 G2 box; other site 550538016823 G3 box; other site 550538016824 Switch II region; other site 550538016825 G4 box; other site 550538016826 G5 box; other site 550538016827 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 550538016828 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 550538016829 Antibiotic Binding Site [chemical binding]; other site 550538016830 HMMPfam hit to PF03143, Translation elongation factor EFTu/EF1A, C-terminal, score 1e-60 550538016831 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.3e-26 550538016832 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 3.3e-96 550538016833 PS00301 GTP-binding elongation factors signature. 550538016834 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016835 pantothenate kinase; Provisional; Region: PRK05439 550538016836 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 550538016837 ATP-binding site [chemical binding]; other site 550538016838 CoA-binding site [chemical binding]; other site 550538016839 Mg2+-binding site [ion binding]; other site 550538016840 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 4.5e-07 550538016841 PS00017 ATP/GTP-binding site motif A (P-loop). 550538016842 Biotin operon repressor [Transcription]; Region: BirA; COG1654 550538016843 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 550538016844 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 550538016845 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 550538016846 HMMPfam hit to PF02237, Biotin protein ligase, C-terminal, score 4.5e-10 550538016847 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 1e-26 550538016848 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1.6e-12 550538016849 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 550538016850 FAD binding domain; Region: FAD_binding_4; pfam01565 550538016851 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 550538016852 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal, score 3.8e-74 550538016853 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 1e-25 550538016854 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 550538016855 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 0.00021 550538016856 PS00201 Flavodoxin signature. 550538016857 potassium transporter; Provisional; Region: PRK10750 550538016858 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 550538016859 HMMPfam hit to PF02386, Cation transporter, score 1.8e-121 550538016860 10 probable transmembrane helices predicted for SG3466 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-207, 238-260, 273-295, 332-354, 396-418 and 456-478 550538016861 hypothetical protein; Provisional; Region: PRK11568 550538016862 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 550538016863 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 550538016864 HMMPfam hit to PF09186, Region of unknown function DUF1949, score 1.1e-17 550538016865 HMMPfam hit to PF01205, Protein of unknown function UPF0029, N-terminal, score 3.1e-63 550538016866 PS00910 Uncharacterized protein family UPF0029 signature. 550538016867 proline dipeptidase; Provisional; Region: PRK13607 550538016868 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 550538016869 active site 550538016870 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 1e-107 550538016871 PS00491 Aminopeptidase P and proline dipeptidase signature. 550538016872 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 550538016873 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 550538016874 substrate binding site [chemical binding]; other site 550538016875 oxyanion hole (OAH) forming residues; other site 550538016876 trimer interface [polypeptide binding]; other site 550538016877 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 550538016878 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 550538016879 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 550538016880 HMMPfam hit to PF00378, Crotonase, core, score 2e-87 550538016881 PS00166 Enoyl-CoA hydratase/isomerase signature. 550538016882 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 3.1e-86 550538016883 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 550538016884 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1.2e-35 550538016885 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 2.9e-05 550538016886 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 550538016887 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 550538016888 dimer interface [polypeptide binding]; other site 550538016889 active site 550538016890 HMMPfam hit to PF00108, Thiolase, score 1.5e-142 550538016891 PS00098 Thiolases acyl-enzyme intermediate signature. 550538016892 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538016893 HMMPfam hit to PF02803, Thiolase, score 2.1e-92 550538016894 PS00737 Thiolases signature 2. 550538016895 PS00099 Thiolases active site. 550538016896 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 550538016897 HMMPfam hit to PF05935, Arylsulphotransferase, score 0 550538016898 FMN reductase; Validated; Region: fre; PRK08051 550538016899 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 550538016900 FAD binding pocket [chemical binding]; other site 550538016901 FAD binding motif [chemical binding]; other site 550538016902 phosphate binding motif [ion binding]; other site 550538016903 beta-alpha-beta structure motif; other site 550538016904 NAD binding pocket [chemical binding]; other site 550538016905 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 2.3e-31 550538016906 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 3.8e-13 550538016907 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 550538016908 HMMPfam hit to PF01977, Carboxylyase-related, score 1.6e-249 550538016909 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 550538016910 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 550538016911 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 550538016912 HMMPfam hit to PF02357, Transcription antitermination protein, NusG, N-terminal, score 3.6e-30 550538016913 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 550538016914 active site 550538016915 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 3.6e-109 550538016916 PS01091 Uncharacterized protein family UPF0006 signature 3. 550538016917 PS01090 Uncharacterized protein family UPF0006 signature 2. 550538016918 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 550538016919 6 probable transmembrane helices predicted for SG3476 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-210 and 215-237 550538016920 HMMPfam hit to PF00902, Sec-independent periplasmic protein translocase, score 1.4e-98 550538016921 PS01218 Uncharacterized protein family UPF0032 signature. 550538016922 sec-independent translocase; Provisional; Region: PRK01770 550538016923 sec-independent translocase; Provisional; Region: tatB; PRK00404 550538016924 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 0.00059 550538016925 1 probable transmembrane helix predicted for SG3477 by TMHMM2.0 at aa 4-21 550538016926 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 550538016927 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 8.4e-13 550538016928 1 probable transmembrane helix predicted for SG3478 by TMHMM2.0 at aa 4-21 550538016929 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 550538016930 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 550538016931 1 probable transmembrane helix predicted for SG3479 by TMHMM2.0 at aa 523-542 550538016932 HMMPfam hit to PF03109, ABC-1, score 1.1e-56 550538016933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 550538016934 SCP-2 sterol transfer family; Region: SCP2; pfam02036 550538016935 HMMPfam hit to PF06843, Protein of unknown function DUF1243, score 4.3e-92 550538016936 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 550538016937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538016938 S-adenosylmethionine binding site [chemical binding]; other site 550538016939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 550538016940 HMMPfam hit to PF01209, UbiE/COQ5 methyltransferase, score 5.7e-179 550538016941 PS01184 ubiE/COQ5 methyltransferase family signature 2. 550538016942 PS01183 ubiE/COQ5 methyltransferase family signature 1. 550538016943 DNA recombination protein RmuC; Provisional; Region: PRK10361 550538016944 RmuC family; Region: RmuC; pfam02646 550538016945 HMMPfam hit to PF02646, RmuC, score 1.3e-156 550538016946 1 probable transmembrane helix predicted for SG3482 by TMHMM2.0 at aa 5-24 550538016947 uridine phosphorylase; Provisional; Region: PRK11178 550538016948 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 550538016949 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 2.5e-110 550538016950 PS01232 Purine and other phosphorylases family 1 signature. 550538016951 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 550538016952 HMMPfam hit to PF01738, Dienelactone hydrolase, score 3.4e-107 550538016953 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 550538016954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538016955 FeS/SAM binding site; other site 550538016956 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 550538016957 HMMPfam hit to PF02810, SEC-C motif, score 1.2e-05 550538016958 HMMPfam hit to PF04055, Radical SAM, score 1.3e-19 550538016959 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 550538016960 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 550538016961 THF binding site; other site 550538016962 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 550538016963 substrate binding site [chemical binding]; other site 550538016964 THF binding site; other site 550538016965 zinc-binding site [ion binding]; other site 550538016966 HMMPfam hit to PF01717, Methionine synthase, vitamin-B12 independent, score 1.7e-229 550538016967 HMMPfam hit to PF08267, Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal, score 2e-196 550538016968 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 550538016969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538016970 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 550538016971 putative dimerization interface [polypeptide binding]; other site 550538016972 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.5e-17 550538016973 PS00044 Bacterial regulatory proteins, lysR family signature. 550538016974 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.4e-44 550538016975 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 550538016976 EamA-like transporter family; Region: EamA; pfam00892 550538016977 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2e-07 550538016978 10 probable transmembrane helices predicted for SG3488 by TMHMM2.0 at aa 2-24, 28-47, 54-76, 80-102, 109-128, 138-157, 170-192, 202-224, 231-253 and 258-275 550538016979 putative hydrolase; Provisional; Region: PRK10976 550538016980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538016981 active site 550538016982 motif I; other site 550538016983 motif II; other site 550538016984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538016985 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 3.8e-87 550538016986 PS01229 Hypothetical cof family signature 2. 550538016987 PS01228 Hypothetical cof family signature 1. 550538016988 lysophospholipase L2; Provisional; Region: PRK10749 550538016989 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 550538016990 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 1.7e-36 550538016991 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 550538016992 5 probable transmembrane helices predicted for SG3491 by TMHMM2.0 at aa 5-27, 39-61, 71-88, 115-137 and 147-169 550538016993 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 3.2e-44 550538016994 threonine efflux system; Provisional; Region: PRK10229 550538016995 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 4.8e-75 550538016996 6 probable transmembrane helices predicted for SG3492 by TMHMM2.0 at aa 4-26, 42-64, 68-87, 119-141, 151-173 and 186-205 550538016997 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 550538016998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538016999 ATP binding site [chemical binding]; other site 550538017000 putative Mg++ binding site [ion binding]; other site 550538017001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538017002 nucleotide binding region [chemical binding]; other site 550538017003 ATP-binding site [chemical binding]; other site 550538017004 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 550538017005 Helicase and RNase D C-terminal; Region: HRDC; smart00341 550538017006 HMMPfam hit to PF00570, Helicase and RNase D C-terminal, HRDC, score 2e-35 550538017007 HMMPfam hit to PF02008, Zinc finger, CXXC-type, score 0.0001 550538017008 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 2e-30 550538017009 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 6.7e-37 550538017010 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 550538017011 dimerization interface [polypeptide binding]; other site 550538017012 substrate binding site [chemical binding]; other site 550538017013 active site 550538017014 calcium binding site [ion binding]; other site 550538017015 HMMPfam hit to PF02253, Phospholipase A1, score 6.6e-152 550538017016 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 550538017017 CoenzymeA binding site [chemical binding]; other site 550538017018 subunit interaction site [polypeptide binding]; other site 550538017019 PHB binding site; other site 550538017020 HMMPfam hit to PF03061, Thioesterase superfamily, score 7.8e-16 550538017021 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 550538017022 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 550538017023 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 7.7e-09 550538017024 8 probable transmembrane helices predicted for SG3496 by TMHMM2.0 at aa 31-53, 58-80, 87-104, 108-125, 138-155, 170-192, 197-219 and 229-248 550538017025 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 550538017026 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 550538017027 Cl binding site [ion binding]; other site 550538017028 oligomer interface [polypeptide binding]; other site 550538017029 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 4.2e-103 550538017030 2 probable transmembrane helices predicted for SG3497 by TMHMM2.0 at aa 255-273 and 288-310 550538017031 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 550538017032 Part of AAA domain; Region: AAA_19; pfam13245 550538017033 Family description; Region: UvrD_C_2; pfam13538 550538017034 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 2.2e-234 550538017035 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017036 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 550538017037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538017038 motif II; other site 550538017039 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 6.3e-23 550538017040 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 550538017041 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 550538017042 active site 550538017043 Int/Topo IB signature motif; other site 550538017044 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 3e-61 550538017045 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 1e-31 550538017046 hypothetical protein; Provisional; Region: PRK10963 550538017047 HMMPfam hit to PF04340, Protein of unknown function DUF484, score 3.3e-113 550538017048 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 550538017049 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 550538017050 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 550538017051 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 4.7e-52 550538017052 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 9.3e-56 550538017053 PS01326 Diaminopimelate epimerase signature. 550538017054 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 550538017055 1 probable transmembrane helix predicted for SG3503 by TMHMM2.0 at aa 7-29 550538017056 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538017058 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 550538017059 4 probable transmembrane helices predicted for SG3506 by TMHMM2.0 at aa 20-42, 47-64, 71-93 and 103-125 550538017060 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 550538017061 putative iron binding site [ion binding]; other site 550538017062 HMMPfam hit to PF01491, Frataxin-like, score 4.5e-73 550538017063 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 550538017064 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 550538017065 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 550538017066 HMMPfam hit to PF01295, Adenylate cyclase, class-I, score 0 550538017067 PS01093 Adenylate cyclases class-I signature 2. 550538017068 PS01092 Adenylate cyclases class-I signature 1. 550538017069 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538017070 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 550538017071 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 550538017072 domain interfaces; other site 550538017073 active site 550538017074 HMMPfam hit to PF01379, Tetrapyrrole biosynthesis, hydroxymethylbilane synthase, score 1.3e-142 550538017075 HMMPfam hit to PF03900, Tetrapyrrole biosynthesis, hydroxymethylbilane synthase, score 2.5e-34 550538017076 PS00533 Porphobilinogen deaminase cofactor-binding site. 550538017077 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 550538017078 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 550538017079 active site 550538017080 HMMPfam hit to PF02602, Tetrapyrrole biosynthesis, uroporphyrinogen III synthase, score 2e-60 550538017081 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 550538017082 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 550538017083 HMMPfam hit to PF04375, HemX, score 6.5e-182 550538017084 1 probable transmembrane helix predicted for SG3511 by TMHMM2.0 at aa 35-57 550538017085 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 550538017086 HemY protein N-terminus; Region: HemY_N; pfam07219 550538017087 HMMPfam hit to PF07219, HemY, N-terminal, score 4.3e-50 550538017088 1 probable transmembrane helix predicted for SG3512 by TMHMM2.0 at aa 21-43 550538017089 PS00215 Mitochondrial energy transfer proteins signature. 550538017090 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 1.9e-06 550538017091 putative transport protein YifK; Provisional; Region: PRK10746 550538017092 HMMPfam hit to PF00324, Amino acid permease-associated region, score 5.4e-126 550538017093 12 probable transmembrane helices predicted for SG3513 by TMHMM2.0 at aa 19-36, 40-59, 93-115, 125-147, 154-176, 191-213, 240-262, 277-299, 331-353, 358-380, 401-423 and 428-450 550538017094 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 550538017095 PS00218 Amino acid permeases signature. 550538017096 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 550538017097 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 550538017098 HMMPfam hit to PF03808, Glycosyl transferase WecB/TagA/CpsF, score 2.5e-93 550538017099 putative common antigen polymerase; Provisional; Region: PRK02975 550538017100 HMMPfam hit to PF06899, WzyE, score 0 550538017101 11 probable transmembrane helices predicted for SG3515 by TMHMM2.0 at aa 4-26, 33-55, 70-89, 116-138, 153-175, 182-201, 205-224, 226-245, 338-360, 381-398 and 408-430 550538017102 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538017103 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 550538017104 HMMPfam hit to PF07429, 4-alpha-L-fucosyltransferase, score 5.9e-264 550538017105 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 550538017106 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 550538017107 12 probable transmembrane helices predicted for SG3517 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 116-138, 145-167, 177-195, 216-238, 253-275, 296-318, 333-355, 362-384 and 390-412 550538017108 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 0.00017 550538017109 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 550538017110 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 550538017111 inhibitor-cofactor binding pocket; inhibition site 550538017112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538017113 catalytic residue [active] 550538017114 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 8.1e-88 550538017115 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 550538017116 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 5.4e-07 550538017118 HMMPfam hit to PF00483, Nucleotidyl transferase, score 9.5e-11 550538017119 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 550538017120 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 550538017121 NAD binding site [chemical binding]; other site 550538017122 substrate binding site [chemical binding]; other site 550538017123 homodimer interface [polypeptide binding]; other site 550538017124 active site 550538017125 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 6.2e-95 550538017126 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 550538017127 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 550538017128 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 550538017129 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, C-terminal, score 3.6e-28 550538017130 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, dimerisation, score 8.9e-47 550538017131 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, N-terminal, score 2.2e-88 550538017132 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 550538017133 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 550538017134 active site 550538017135 homodimer interface [polypeptide binding]; other site 550538017136 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 1.3e-199 550538017137 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 550538017138 Chain length determinant protein; Region: Wzz; pfam02706 550538017139 2 probable transmembrane helices predicted for SG3524 by TMHMM2.0 at aa 29-51 and 323-342 550538017140 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 2e-18 550538017141 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 550538017142 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 550538017143 Mg++ binding site [ion binding]; other site 550538017144 putative catalytic motif [active] 550538017145 substrate binding site [chemical binding]; other site 550538017146 11 probable transmembrane helices predicted for SG3525 by TMHMM2.0 at aa 5-24, 45-65, 69-88, 105-127, 131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-338 550538017147 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 7.6e-11 550538017148 PS00962 Ribosomal protein S2 signature 1. 550538017149 transcription termination factor Rho; Provisional; Region: rho; PRK09376 550538017150 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 550538017151 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 550538017152 RNA binding site [nucleotide binding]; other site 550538017153 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 550538017154 multimer interface [polypeptide binding]; other site 550538017155 Walker A motif; other site 550538017156 ATP binding site [chemical binding]; other site 550538017157 Walker B motif; other site 550538017158 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 6.8e-79 550538017159 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017160 PS00464 Ribosomal protein L22 signature. 550538017161 HMMPfam hit to PF07497, Rho termination factor, RNA-binding, score 2.9e-59 550538017162 HMMPfam hit to PF07498, Rho termination factor, N-terminal, score 1.1e-20 550538017163 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 550538017164 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 550538017165 catalytic residues [active] 550538017166 HMMPfam hit to PF00085, Thioredoxin domain, score 4e-53 550538017167 PS00194 Thioredoxin family active site. 550538017168 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 550538017169 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 550538017170 ATP binding site [chemical binding]; other site 550538017171 Mg++ binding site [ion binding]; other site 550538017172 motif III; other site 550538017173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538017174 nucleotide binding region [chemical binding]; other site 550538017175 ATP-binding site [chemical binding]; other site 550538017176 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.2e-62 550538017177 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017178 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 550538017179 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.9e-34 550538017180 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 550538017181 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 550538017182 HMMPfam hit to PF02541, Ppx/GppA phosphatase, score 8.8e-136 550538017183 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 550538017184 Part of AAA domain; Region: AAA_19; pfam13245 550538017185 Family description; Region: UvrD_C_2; pfam13538 550538017186 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 9.1e-228 550538017187 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017189 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 550538017190 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 550538017191 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 9.1e-43 550538017192 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 550538017193 ketol-acid reductoisomerase; Validated; Region: PRK05225 550538017194 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 550538017195 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 550538017196 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 550538017197 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase C-terminal, score 2.1e-133 550538017198 HMMPfam hit to PF07991, Acetohydroxy acid isomeroreductase, catalytic, score 7.4e-86 550538017199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538017200 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 550538017201 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 550538017202 putative dimerization interface [polypeptide binding]; other site 550538017203 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3e-23 550538017204 PS00044 Bacterial regulatory proteins, lysR family signature. 550538017205 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.3e-33 550538017206 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 550538017207 Phage-related protein [Function unknown]; Region: COG4679 550538017208 HMMPfam hit to PF05973, Protein of unknown function DUF891, score 6.6e-26 550538017209 threonine dehydratase; Reviewed; Region: PRK09224 550538017210 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 550538017211 tetramer interface [polypeptide binding]; other site 550538017212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538017213 catalytic residue [active] 550538017214 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 550538017215 putative Ile/Val binding site [chemical binding]; other site 550538017216 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 550538017217 putative Ile/Val binding site [chemical binding]; other site 550538017218 HMMPfam hit to PF00585, Threonine dehydratase, C-terminal, score 1e-46 550538017219 HMMPfam hit to PF00585, Threonine dehydratase, C-terminal, score 1.5e-49 550538017220 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1.5e-105 550538017221 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 550538017222 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 550538017223 HMMPfam hit to PF00920, Dihydroxy-acid and 6-phosphogluconate dehydratase, score 0 550538017224 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 550538017225 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017226 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 550538017227 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 550538017228 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 550538017229 homodimer interface [polypeptide binding]; other site 550538017230 substrate-cofactor binding pocket; other site 550538017231 catalytic residue [active] 550538017232 HMMPfam hit to PF01063, Aminotransferase, class IV, score 1.2e-140 550538017233 PS00770 Aminotransferases class-IV signature. 550538017234 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 550538017235 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 550538017236 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 550538017237 PYR/PP interface [polypeptide binding]; other site 550538017238 dimer interface [polypeptide binding]; other site 550538017239 TPP binding site [chemical binding]; other site 550538017240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 550538017241 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 550538017242 TPP-binding site [chemical binding]; other site 550538017243 dimer interface [polypeptide binding]; other site 550538017244 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 2.3e-77 550538017245 PS00187 Thiamine pyrophosphate enzymes signature. 550538017246 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 2.5e-64 550538017247 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 7.6e-105 550538017248 PS00044 Bacterial regulatory proteins, lysR family signature. 550538017249 putative ATP-dependent protease; Provisional; Region: PRK09862 550538017250 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 550538017251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538017252 Walker A motif; other site 550538017253 ATP binding site [chemical binding]; other site 550538017254 Walker B motif; other site 550538017255 arginine finger; other site 550538017256 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 550538017257 HMMPfam hit to PF01078, Magnesium chelatase, ChlI subunit, score 7.8e-138 550538017258 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017259 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538017260 hypothetical protein; Provisional; Region: PRK11027 550538017261 HMMPfam hit to PF04219, Protein of unknown function DUF413, score 1.1e-48 550538017262 transcriptional regulator HdfR; Provisional; Region: PRK03601 550538017263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538017264 LysR substrate binding domain; Region: LysR_substrate; pfam03466 550538017265 dimerization interface [polypeptide binding]; other site 550538017266 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.5e-20 550538017267 PS00044 Bacterial regulatory proteins, lysR family signature. 550538017268 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.2e-06 550538017269 Transcriptional regulators [Transcription]; Region: FadR; COG2186 550538017270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538017271 DNA-binding site [nucleotide binding]; DNA binding site 550538017272 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 550538017273 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.3e-22 550538017274 PS00043 Bacterial regulatory proteins, gntR family signature. 550538017275 HMMPfam hit to PF07729, GntR, C-terminal, score 4.7e-30 550538017276 putative transporter; Provisional; Region: PRK10504 550538017277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017278 putative substrate translocation pore; other site 550538017279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017280 14 probable transmembrane helices predicted for SG3546 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 103-125, 137-159, 164-181, 201-218, 222-244, 264-286, 291-313, 325-347, 351-373, 394-416 and 431-450 550538017281 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.3e-49 550538017282 transcriptional repressor RbsR; Provisional; Region: PRK10423 550538017283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538017284 DNA binding site [nucleotide binding] 550538017285 domain linker motif; other site 550538017286 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 550538017287 dimerization interface [polypeptide binding]; other site 550538017288 ligand binding site [chemical binding]; other site 550538017289 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.8e-23 550538017290 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1e-13 550538017291 PS00356 Bacterial regulatory proteins, lacI family signature. 550538017292 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538017293 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 550538017294 substrate binding site [chemical binding]; other site 550538017295 dimer interface [polypeptide binding]; other site 550538017296 ATP binding site [chemical binding]; other site 550538017297 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.5e-90 550538017298 PS00584 pfkB family of carbohydrate kinases signature 2. 550538017299 PS00583 pfkB family of carbohydrate kinases signature 1. 550538017300 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 550538017301 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 550538017302 ligand binding site [chemical binding]; other site 550538017303 dimerization interface [polypeptide binding]; other site 550538017304 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.4e-13 550538017305 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 550538017306 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 550538017307 TM-ABC transporter signature motif; other site 550538017308 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 2.6e-72 550538017309 8 probable transmembrane helices predicted for SG3550 by TMHMM2.0 at aa 21-43, 53-72, 74-93, 97-119, 126-145, 165-187, 221-243 and 275-297 550538017310 the sequence has been checked and is believed to be correct 550538017311 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-30 550538017312 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-45 550538017313 D-ribose pyranase; Provisional; Region: PRK11797 550538017314 HMMPfam hit to PF05025, RbsD or FucU transport, score 1.4e-87 550538017315 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 550538017316 potassium uptake protein; Region: kup; TIGR00794 550538017317 HMMPfam hit to PF02705, K+ potassium transporter, score 0 550538017318 12 probable transmembrane helices predicted for SG3553 by TMHMM2.0 at aa 7-29, 49-71, 102-124, 134-156, 168-190, 210-232, 245-267, 287-309, 335-357, 363-385, 392-414 and 419-441 550538017319 regulatory ATPase RavA; Provisional; Region: PRK13531 550538017320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538017321 Walker A motif; other site 550538017322 ATP binding site [chemical binding]; other site 550538017323 Walker B motif; other site 550538017324 arginine finger; other site 550538017325 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 550538017326 HMMPfam hit to PF07728, ATPase associated with various cellular activities, AAA-5, score 9.5e-48 550538017327 hypothetical protein; Provisional; Region: yieM; PRK10997 550538017328 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 550538017329 metal ion-dependent adhesion site (MIDAS); other site 550538017330 the sequence has been checked and is believed to be correct 550538017331 HMMPfam hit to PF03590, Aspartate--ammonia ligase, score 1.3e-177 550538017332 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 550538017333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 550538017334 putative DNA binding site [nucleotide binding]; other site 550538017335 putative Zn2+ binding site [ion binding]; other site 550538017336 AsnC family; Region: AsnC_trans_reg; pfam01037 550538017337 PS00519 Bacterial regulatory proteins, asnC family signature. 550538017338 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 4.7e-21 550538017339 FMN-binding protein MioC; Provisional; Region: PRK09004 550538017340 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 8.2e-34 550538017341 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 550538017342 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 550538017343 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 550538017344 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 7.4e-278 550538017345 PS01280 Glucose inhibited division protein A family signature 1. 550538017346 PS01281 Glucose inhibited division protein A family signature 2. 550538017347 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 550538017348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538017349 S-adenosylmethionine binding site [chemical binding]; other site 550538017350 HMMPfam hit to PF02527, Glucose inhibited division protein, score 4.2e-93 550538017351 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 550538017352 HMMPfam hit to PF03899, ATPase, F0 complex, subunit I, proteobacteria-type, score 9.7e-65 550538017353 4 probable transmembrane helices predicted for SG3561 by TMHMM2.0 at aa 15-31, 36-58, 73-95 and 100-122 550538017354 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 550538017355 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 550538017356 5 probable transmembrane helices predicted for SG3562 by TMHMM2.0 at aa 36-58, 100-122, 142-164, 211-233 and 243-265 550538017357 HMMPfam hit to PF00119, ATPase, F0 complex, subunit A, score 3e-95 550538017358 PS00449 ATP synthase a subunit signature. 550538017359 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 550538017360 HMMPfam hit to PF00137, ATPase, F0/V0 complex, subunit C, score 1.2e-24 550538017361 2 probable transmembrane helices predicted for SG3563 by TMHMM2.0 at aa 10-32 and 53-75 550538017362 PS00605 ATP synthase c subunit signature. 550538017363 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 550538017364 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 550538017365 1 probable transmembrane helix predicted for SG3564 by TMHMM2.0 at aa 5-27 550538017366 HMMPfam hit to PF00430, ATPase, F0 complex, subunit B/B', bacterial and chloroplast, score 1.1e-41 550538017367 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 550538017368 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 550538017369 HMMPfam hit to PF00213, ATPase, F1 complex, OSCP/delta subunit, score 6.1e-77 550538017370 PS00389 ATP synthase delta (OSCP) subunit signature. 550538017371 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 550538017372 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 550538017373 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 550538017374 beta subunit interaction interface [polypeptide binding]; other site 550538017375 Walker A motif; other site 550538017376 ATP binding site [chemical binding]; other site 550538017377 Walker B motif; other site 550538017378 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 550538017379 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 3.1e-16 550538017380 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 8e-120 550538017381 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017382 PS00152 ATP synthase alpha and beta subunits signature. 550538017383 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 1.2e-29 550538017384 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 550538017385 core domain interface [polypeptide binding]; other site 550538017386 delta subunit interface [polypeptide binding]; other site 550538017387 epsilon subunit interface [polypeptide binding]; other site 550538017388 HMMPfam hit to PF00231, ATPase, F1 complex, gamma subunit, score 2.1e-177 550538017389 PS00153 ATP synthase gamma subunit signature. 550538017390 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 550538017391 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 550538017392 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 550538017393 alpha subunit interaction interface [polypeptide binding]; other site 550538017394 Walker A motif; other site 550538017395 ATP binding site [chemical binding]; other site 550538017396 Walker B motif; other site 550538017397 inhibitor binding site; inhibition site 550538017398 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 550538017399 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 7.5e-26 550538017400 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 4.5e-95 550538017401 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017402 PS00152 ATP synthase alpha and beta subunits signature. 550538017403 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 1.7e-53 550538017404 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 550538017405 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 550538017406 gamma subunit interface [polypeptide binding]; other site 550538017407 epsilon subunit interface [polypeptide binding]; other site 550538017408 LBP interface [polypeptide binding]; other site 550538017409 HMMPfam hit to PF02823, ATPase, F1 complex, delta/epsilon subunit, score 2.3e-39 550538017410 HMMPfam hit to PF00401, ATPase, F1 complex, delta/epsilon subunit, score 1.4e-12 550538017411 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 550538017412 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 550538017413 6 probable transmembrane helices predicted for SG3570 by TMHMM2.0 at aa 25-47, 62-81, 94-116, 120-142, 158-192 and 207-229 550538017414 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 550538017415 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 550538017416 Substrate binding site; other site 550538017417 Mg++ binding site; other site 550538017418 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 550538017419 active site 550538017420 substrate binding site [chemical binding]; other site 550538017421 CoA binding site [chemical binding]; other site 550538017422 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 2.6e-08 550538017423 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.063 550538017424 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 5.9 550538017425 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.056 550538017426 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 22 550538017427 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.1 550538017428 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 14 550538017429 PS00101 Hexapeptide-repeat containing-transferases signature. 550538017430 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.6 550538017431 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 550538017432 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 550538017433 glutaminase active site [active] 550538017434 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 550538017435 dimer interface [polypeptide binding]; other site 550538017436 active site 550538017437 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 550538017438 dimer interface [polypeptide binding]; other site 550538017439 active site 550538017440 PS00443 Glutamine amidotransferases class-II active site. 550538017441 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1e-62 550538017442 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 3.1e-43 550538017443 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 3.2e-38 550538017444 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 550538017445 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 550538017446 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 550538017447 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 5.1e-30 550538017448 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 550538017449 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 550538017450 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 550538017451 shikimate binding site; other site 550538017452 NAD(P) binding site [chemical binding]; other site 550538017453 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate binding, N-terminal, score 9.7e-26 550538017454 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 2e-08 550538017456 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 4.6e-57 550538017457 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 8.3e-10 550538017458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538017459 substrate binding pocket [chemical binding]; other site 550538017460 membrane-bound complex binding site; other site 550538017461 hinge residues; other site 550538017462 1 probable transmembrane helix predicted for SG3577 by TMHMM2.0 at aa 7-29 550538017463 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.7e-35 550538017464 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 550538017465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538017466 dimer interface [polypeptide binding]; other site 550538017467 conserved gate region; other site 550538017468 putative PBP binding loops; other site 550538017469 ABC-ATPase subunit interface; other site 550538017470 6 probable transmembrane helices predicted for SG3578 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304 550538017471 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.5e-08 550538017472 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538017473 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 550538017474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538017475 dimer interface [polypeptide binding]; other site 550538017476 conserved gate region; other site 550538017477 putative PBP binding loops; other site 550538017478 ABC-ATPase subunit interface; other site 550538017479 6 probable transmembrane helices predicted for SG3579 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290 550538017480 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.4e-39 550538017481 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538017482 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 550538017483 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 550538017484 Walker A/P-loop; other site 550538017485 ATP binding site [chemical binding]; other site 550538017486 Q-loop/lid; other site 550538017487 ABC transporter signature motif; other site 550538017488 Walker B; other site 550538017489 D-loop; other site 550538017490 H-loop/switch region; other site 550538017491 HMMPfam hit to PF00005, ABC transporter related, score 8.5e-72 550538017492 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017493 PS00211 ABC transporters family signature. 550538017494 transcriptional regulator PhoU; Provisional; Region: PRK11115 550538017495 PhoU domain; Region: PhoU; pfam01895 550538017496 PhoU domain; Region: PhoU; pfam01895 550538017497 HMMPfam hit to PF01895, PhoU, score 1.1e-32 550538017498 HMMPfam hit to PF01895, PhoU, score 5.8e-31 550538017499 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 550538017500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538017501 active site 550538017502 motif I; other site 550538017503 motif II; other site 550538017504 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.6e-25 550538017505 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 550538017506 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 2.5e-28 550538017507 13 probable transmembrane helices predicted for SG3583 by TMHMM2.0 at aa 30-52, 62-84, 86-108, 113-135, 142-161, 176-198, 205-222, 253-275, 295-317, 327-349, 356-374, 389-411 and 424-442 550538017508 PS00267 Tachykinin family signature. 550538017509 Predicted flavoprotein [General function prediction only]; Region: COG0431 550538017510 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 550538017511 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 7.7e-63 550538017512 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 550538017513 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 550538017514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538017515 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 550538017516 substrate binding pocket [chemical binding]; other site 550538017517 dimerization interface [polypeptide binding]; other site 550538017518 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.6e-07 550538017519 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.6e-13 550538017520 PS00044 Bacterial regulatory proteins, lysR family signature. 550538017521 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 550538017522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017523 putative substrate translocation pore; other site 550538017524 10 probable transmembrane helices predicted for SG3587 by TMHMM2.0 at aa 5-24, 39-58, 70-89, 99-116, 129-151, 156-178, 210-232, 242-264, 295-317 and 332-354 550538017525 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 4e-38 550538017526 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 550538017527 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 550538017528 trmE is a tRNA modification GTPase; Region: trmE; cd04164 550538017529 G1 box; other site 550538017530 GTP/Mg2+ binding site [chemical binding]; other site 550538017531 Switch I region; other site 550538017532 G2 box; other site 550538017533 Switch II region; other site 550538017534 G3 box; other site 550538017535 G4 box; other site 550538017536 G5 box; other site 550538017537 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 550538017538 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 6.2e-43 550538017539 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017540 membrane protein insertase; Provisional; Region: PRK01318 550538017541 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 550538017542 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 550538017543 HMMPfam hit to PF02096, 60 kDa inner membrane insertion protein, score 3.7e-124 550538017544 4 probable transmembrane helices predicted for SG3589 by TMHMM2.0 at aa 7-24, 346-368, 419-441 and 497-519 550538017545 hypothetical protein; Validated; Region: PRK00041 550538017546 HMMPfam hit to PF01809, Protein of unknown function DUF37, score 6.8e-49 550538017547 ribonuclease P; Reviewed; Region: rnpA; PRK01732 550538017548 HMMPfam hit to PF00825, Bacterial ribonuclease P protein, score 1.3e-60 550538017549 PS00648 Bacterial ribonuclease P protein component signature. 550538017550 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 550538017551 HMMPfam hit to PF00468, Ribosomal protein L34, score 7e-22 550538017552 PS00784 Ribosomal protein L34 signature. 550538017553 DnaA N-terminal domain; Region: DnaA_N; pfam11638 550538017554 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 550538017555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538017556 Walker A motif; other site 550538017557 ATP binding site [chemical binding]; other site 550538017558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 550538017559 Walker B motif; other site 550538017560 arginine finger; other site 550538017561 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 550538017562 DnaA box-binding interface [nucleotide binding]; other site 550538017563 HMMPfam hit to PF00308, Chromosomal replication initiator, DnaA, score 2.8e-152 550538017564 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017565 HMMPfam hit to PF08299, Chromosomal replication initiator, DnaA C-terminal, score 2.1e-48 550538017566 PS01008 DnaA protein signature. 550538017567 DNA polymerase III subunit beta; Validated; Region: PRK05643 550538017568 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 550538017569 putative DNA binding surface [nucleotide binding]; other site 550538017570 dimer interface [polypeptide binding]; other site 550538017571 beta-clamp/clamp loader binding surface; other site 550538017572 beta-clamp/translesion DNA polymerase binding surface; other site 550538017573 HMMPfam hit to PF00712, DNA polymerase III, beta chain, score 3.5e-68 550538017574 HMMPfam hit to PF02767, DNA polymerase III, beta chain, score 7.4e-70 550538017575 HMMPfam hit to PF02768, DNA polymerase III, beta chain, score 1.7e-62 550538017576 recF protein; Region: recf; TIGR00611 550538017577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538017578 Walker A/P-loop; other site 550538017579 ATP binding site [chemical binding]; other site 550538017580 Q-loop/lid; other site 550538017581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538017582 ABC transporter signature motif; other site 550538017583 Walker B; other site 550538017584 D-loop; other site 550538017585 H-loop/switch region; other site 550538017586 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1.1e-60 550538017587 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017588 PS00617 RecF protein signature 1. 550538017589 PS00618 RecF protein signature 2. 550538017590 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 550538017591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538017592 Mg2+ binding site [ion binding]; other site 550538017593 G-X-G motif; other site 550538017594 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 550538017595 anchoring element; other site 550538017596 dimer interface [polypeptide binding]; other site 550538017597 ATP binding site [chemical binding]; other site 550538017598 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 550538017599 active site 550538017600 putative metal-binding site [ion binding]; other site 550538017601 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 550538017602 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.3e-32 550538017603 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 6.8e-97 550538017604 HMMPfam hit to PF01751, TOPRIM, score 1.1e-05 550538017605 PS00177 DNA topoisomerase II signature. 550538017606 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 9.9e-47 550538017607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538017608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538017609 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 550538017610 putative dimerization interface [polypeptide binding]; other site 550538017611 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.1e-23 550538017612 1 probable transmembrane helix predicted for SG3597 by TMHMM2.0 at aa 93-115 550538017613 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.3e-18 550538017614 PS00044 Bacterial regulatory proteins, lysR family signature. 550538017615 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 550538017616 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 550538017617 active site pocket [active] 550538017618 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 8.6e-15 550538017619 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 5e-22 550538017620 the sequence has been checked and is believed to be correct 550538017621 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 9.7e-58 550538017622 sugar phosphate phosphatase; Provisional; Region: PRK10513 550538017623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538017624 active site 550538017625 motif I; other site 550538017626 motif II; other site 550538017627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538017628 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 2.3e-93 550538017629 PS01229 Hypothetical cof family signature 2. 550538017630 Transcriptional regulators [Transcription]; Region: FadR; COG2186 550538017631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538017632 DNA-binding site [nucleotide binding]; DNA binding site 550538017633 FCD domain; Region: FCD; pfam07729 550538017634 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 8.2e-16 550538017635 PS00043 Bacterial regulatory proteins, gntR family signature. 550538017636 HMMPfam hit to PF07729, GntR, C-terminal, score 3.2e-35 550538017637 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 550538017638 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 550538017639 HMMPfam hit to PF05035, 2-keto-3-deoxy-galactonokinase, score 1.5e-181 550538017640 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 550538017641 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 550538017642 active site 550538017643 intersubunit interface [polypeptide binding]; other site 550538017644 catalytic residue [active] 550538017645 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 1.6e-11 550538017646 galactonate dehydratase; Provisional; Region: PRK14017 550538017647 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 550538017648 putative active site pocket [active] 550538017649 putative metal binding site [ion binding]; other site 550538017650 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 4.4e-56 550538017651 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 550538017652 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 5.2e-23 550538017653 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 550538017654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017655 D-galactonate transporter; Region: 2A0114; TIGR00893 550538017656 putative substrate translocation pore; other site 550538017657 10 probable transmembrane helices predicted for SG3605 by TMHMM2.0 at aa 31-53, 68-90, 97-119, 181-203, 257-278, 293-315, 322-344, 354-376, 389-411 and 416-438 550538017658 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.2e-66 550538017660 HMMPfam hit to PF01627, Hpt, score 4e-13 550538017661 HMMPfam hit to PF00072, Response regulator receiver, score 3e-18 550538017662 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.4e-40 550538017663 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 8e-18 550538017664 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.2e-09 550538017665 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 550538017666 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 550538017667 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.4e-98 550538017668 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 550538017669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538017670 active site 550538017671 phosphorylation site [posttranslational modification] 550538017672 intermolecular recognition site; other site 550538017673 dimerization interface [polypeptide binding]; other site 550538017674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538017675 DNA binding site [nucleotide binding] 550538017676 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.1e-15 550538017677 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 550538017678 HMMPfam hit to PF00072, Response regulator receiver, score 5.2e-39 550538017679 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 550538017680 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 550538017681 HMMPfam hit to PF03264, NapC/NirT cytochrome c, N-terminal, score 3.1e-120 550538017682 1 probable transmembrane helix predicted for SG3610 by TMHMM2.0 at aa 17-39 550538017683 PS00190 Cytochrome c family heme-binding site signature. 550538017684 PS00190 Cytochrome c family heme-binding site signature. 550538017685 PS00190 Cytochrome c family heme-binding site signature. 550538017686 PS00190 Cytochrome c family heme-binding site signature. 550538017687 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 550538017688 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 550538017689 molybdopterin cofactor binding site [chemical binding]; other site 550538017690 substrate binding site [chemical binding]; other site 550538017691 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 550538017692 molybdopterin cofactor binding site; other site 550538017693 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.5e-182 550538017694 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538017695 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.2e-32 550538017696 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538017697 chaperone protein TorD; Validated; Region: torD; PRK04976 550538017698 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 1.5e-50 550538017699 Haem-binding domain; Region: Haem_bd; pfam14376 550538017700 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 550538017701 PS00190 Cytochrome c family heme-binding site signature. 550538017702 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 3.4e-108 550538017703 PS00190 Cytochrome c family heme-binding site signature. 550538017704 PS00190 Cytochrome c family heme-binding site signature. 550538017705 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 550538017706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538017707 Walker A/P-loop; other site 550538017708 ATP binding site [chemical binding]; other site 550538017709 Q-loop/lid; other site 550538017710 ABC transporter signature motif; other site 550538017711 Walker B; other site 550538017712 D-loop; other site 550538017713 H-loop/switch region; other site 550538017714 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-48 550538017715 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017716 PS00211 ABC transporters family signature. 550538017717 heme exporter protein CcmB; Region: ccmB; TIGR01190 550538017718 HMMPfam hit to PF03379, Cytochrome c-type biogenesis protein CcmB, score 2.5e-111 550538017719 6 probable transmembrane helices predicted for SG3615 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 128-150, 157-179 and 194-216 550538017720 heme exporter protein CcmC; Region: ccmC; TIGR01191 550538017721 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 1.4e-56 550538017722 6 probable transmembrane helices predicted for SG3616 by TMHMM2.0 at aa 21-43, 63-85, 92-114, 129-148, 155-177 and 204-226 550538017723 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 550538017724 HMMPfam hit to PF04995, Heme exporter protein D (CcmD), score 2.7e-16 550538017725 1 probable transmembrane helix predicted for SG3617 by TMHMM2.0 at aa 15-37 550538017726 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 550538017727 HMMPfam hit to PF03100, CcmE/CycJ protein, score 4.6e-91 550538017728 1 probable transmembrane helix predicted for SG3618 by TMHMM2.0 at aa 7-29 550538017729 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 550538017730 15 probable transmembrane helices predicted for SG3619 by TMHMM2.0 at aa 5-27, 40-62, 95-114, 121-143, 176-198, 211-233, 248-265, 277-299, 314-332, 353-375, 390-412, 425-444, 449-468, 481-503 and 610-629 550538017731 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 1.3e-82 550538017732 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 550538017733 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 550538017734 catalytic residues [active] 550538017735 central insert; other site 550538017736 1 probable transmembrane helix predicted for SG3620 by TMHMM2.0 at aa 5-24 550538017737 HMMPfam hit to PF08534, Redoxin, score 2.5e-27 550538017738 PS00194 Thioredoxin family active site. 550538017739 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 550538017740 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 550538017741 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 2.8e-68 550538017742 2 probable transmembrane helices predicted for SG3621 by TMHMM2.0 at aa 106-128 and 153-175 550538017743 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 550538017744 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017745 hypothetical protein; Provisional; Region: PRK11616 550538017746 HMMPfam hit to PF07119, Protein of unknown function DUF1375, score 1.4e-38 550538017747 2 probable transmembrane helices predicted for SG3623 by TMHMM2.0 at aa 7-29 and 57-79 550538017748 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538017749 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 550538017750 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 550538017751 putative dimer interface [polypeptide binding]; other site 550538017752 HMMPfam hit to PF00011, Heat shock protein Hsp20, score 7.9e-32 550538017753 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 550538017754 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 550538017755 putative dimer interface [polypeptide binding]; other site 550538017756 HMMPfam hit to PF00011, Heat shock protein Hsp20, score 2.2e-26 550538017757 putative transporter; Validated; Region: PRK03818 550538017758 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 550538017759 TrkA-C domain; Region: TrkA_C; pfam02080 550538017760 TrkA-C domain; Region: TrkA_C; pfam02080 550538017761 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 550538017762 10 probable transmembrane helices predicted for SG3626 by TMHMM2.0 at aa 4-21, 28-46, 61-83, 95-117, 160-182, 374-396, 400-419, 431-448, 463-485 and 613-635 550538017763 HMMPfam hit to PF06826, YidE/YbjL duplication, score 1.8e-61 550538017764 HMMPfam hit to PF02080, TrkA-C, score 5.3e-10 550538017765 HMMPfam hit to PF02080, TrkA-C, score 1.6e-12 550538017766 HMMPfam hit to PF06826, YidE/YbjL duplication, score 5.4e-53 550538017767 Predicted membrane protein [Function unknown]; Region: COG2149 550538017768 HMMPfam hit to PF02656, Protein of unknown function DUF202, score 1.3e-67 550538017769 3 probable transmembrane helices predicted for SG3627 by TMHMM2.0 at aa 21-40, 50-72 and 92-114 550538017770 Domain of unknown function (DUF202); Region: DUF202; pfam02656 550538017771 3 probable transmembrane helices predicted for SG3628 by TMHMM2.0 at aa 21-43, 48-70 and 91-113 550538017772 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 550538017773 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 550538017774 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 550538017775 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 550538017776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538017777 catalytic residue [active] 550538017778 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 9.6e-54 550538017779 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 550538017780 permease DsdX; Provisional; Region: PRK09921 550538017781 gluconate transporter; Region: gntP; TIGR00791 550538017782 HMMPfam hit to PF02447, Gluconate transporter, score 5.3e-245 550538017783 12 probable transmembrane helices predicted for SG3631 by TMHMM2.0 at aa 4-23, 30-49, 54-76, 104-126, 146-168, 175-197, 226-248, 261-283, 303-322, 343-365, 385-407 and 420-442 550538017784 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 550538017785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538017786 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 550538017787 dimerization interface [polypeptide binding]; other site 550538017788 substrate binding pocket [chemical binding]; other site 550538017789 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2e-20 550538017790 PS00044 Bacterial regulatory proteins, lysR family signature. 550538017791 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.4e-26 550538017792 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 550538017793 1 probable transmembrane helix predicted for SG3633 by TMHMM2.0 at aa 7-26 550538017794 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 550538017795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017796 putative substrate translocation pore; other site 550538017797 12 probable transmembrane helices predicted for SG3634 by TMHMM2.0 at aa 7-29, 44-66, 75-94, 98-120, 133-155, 165-182, 203-225, 240-262, 275-297, 301-323, 330-352 and 362-384 550538017798 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.8e-44 550538017799 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 550538017800 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 550538017801 10 probable transmembrane helices predicted for SG3635 by TMHMM2.0 at aa 4-23, 30-52, 57-76, 89-108, 112-134, 141-158, 168-190, 207-226, 230-252 and 257-276 550538017802 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.3e-07 550538017803 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 6.9e-05 550538017804 HMMPfam hit to PF08049, IlvB leader peptide, score 7.7e-13 550538017805 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 550538017806 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 550538017807 PYR/PP interface [polypeptide binding]; other site 550538017808 dimer interface [polypeptide binding]; other site 550538017809 TPP binding site [chemical binding]; other site 550538017810 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 550538017811 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 550538017812 TPP-binding site [chemical binding]; other site 550538017813 dimer interface [polypeptide binding]; other site 550538017814 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 1.1e-105 550538017815 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 6e-66 550538017816 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 9.2e-68 550538017817 PS00187 Thiamine pyrophosphate enzymes signature. 550538017818 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 550538017819 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 550538017820 putative valine binding site [chemical binding]; other site 550538017821 dimer interface [polypeptide binding]; other site 550538017822 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.3e-09 550538017823 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 550538017824 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 550538017825 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538017826 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.8e-30 550538017827 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2e-05 550538017828 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538017829 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 550538017830 substrate binding site [chemical binding]; other site 550538017831 dimer interface [polypeptide binding]; other site 550538017832 ATP binding site [chemical binding]; other site 550538017833 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 3.5e-64 550538017834 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 550538017835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017836 putative substrate translocation pore; other site 550538017837 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538017838 12 probable transmembrane helices predicted for SG3642 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 109-128, 149-171, 205-227, 256-275, 290-312, 319-336, 340-362, 375-397 and 401-423 550538017839 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.4e-25 550538017840 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 550538017841 active site 550538017842 catalytic residues [active] 550538017843 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 550538017844 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 550538017845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538017846 active site 550538017847 phosphorylation site [posttranslational modification] 550538017848 intermolecular recognition site; other site 550538017849 dimerization interface [polypeptide binding]; other site 550538017850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538017851 DNA binding residues [nucleotide binding] 550538017852 dimerization interface [polypeptide binding]; other site 550538017853 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-39 550538017854 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 5.6e-29 550538017855 PS00622 Bacterial regulatory proteins, luxR family signature. 550538017856 sensory histidine kinase UhpB; Provisional; Region: PRK11644 550538017857 MASE1; Region: MASE1; pfam05231 550538017858 Histidine kinase; Region: HisKA_3; pfam07730 550538017859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538017860 ATP binding site [chemical binding]; other site 550538017861 Mg2+ binding site [ion binding]; other site 550538017862 G-X-G motif; other site 550538017863 7 probable transmembrane helices predicted for SG3646 by TMHMM2.0 at aa 7-29, 78-100, 112-130, 140-162, 186-205, 220-242 and 255-274 550538017864 HMMPfam hit to PF05231, MASE1, score 1.8e-67 550538017865 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 4e-17 550538017866 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.9e-21 550538017867 regulatory protein UhpC; Provisional; Region: PRK11663 550538017868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017869 putative substrate translocation pore; other site 550538017870 12 probable transmembrane helices predicted for SG3647 by TMHMM2.0 at aa 26-45, 67-89, 96-118, 122-144, 156-178, 183-205, 245-267, 287-309, 322-339, 344-366, 379-401 and 406-428 550538017871 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.8e-58 550538017872 PS00942 glpT family of transporters signature. 550538017873 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 550538017874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017875 putative substrate translocation pore; other site 550538017876 12 probable transmembrane helices predicted for SG3648 by TMHMM2.0 at aa 28-45, 67-89, 96-118, 123-145, 158-180, 190-212, 250-272, 292-314, 321-343, 353-375, 388-407 and 422-441 550538017877 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1e-31 550538017878 PS00942 glpT family of transporters signature. 550538017879 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 550538017880 HMMPfam hit to PF06711, Protein of unknown function DUF1198, score 6.1e-131 550538017881 1 probable transmembrane helix predicted for SG3649 by TMHMM2.0 at aa 4-21 550538017882 Predicted transcriptional regulator [Transcription]; Region: COG2944 550538017883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538017884 non-specific DNA binding site [nucleotide binding]; other site 550538017885 salt bridge; other site 550538017886 sequence-specific DNA binding site [nucleotide binding]; other site 550538017887 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.1e-08 550538017888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 550538017889 HMMPfam hit to PF06296, Protein of unknown function DUF1044, score 3.5e-77 550538017890 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 550538017891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538017892 putative substrate translocation pore; other site 550538017893 12 probable transmembrane helices predicted for SG3652 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 145-167, 177-196, 217-239, 254-276, 283-302, 307-329, 341-363 and 367-389 550538017894 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 4.4e-40 550538017895 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 550538017896 beta-galactosidase; Region: BGL; TIGR03356 550538017897 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 2.7e-134 550538017898 PS00572 Glycosyl hydrolases family 1 active site. 550538017899 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 550538017900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538017901 Walker A motif; other site 550538017902 ATP binding site [chemical binding]; other site 550538017903 Walker B motif; other site 550538017904 arginine finger; other site 550538017905 Transcriptional antiterminator [Transcription]; Region: COG3933 550538017906 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 550538017907 active site 550538017908 active pocket/dimerization site; other site 550538017909 phosphorylation site [posttranslational modification] 550538017910 PRD domain; Region: PRD; pfam00874 550538017911 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 7.3e-62 550538017912 PS00017 ATP/GTP-binding site motif A (P-loop). 550538017913 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 550538017914 HMMPfam hit to PF00874, PRD, score 5.6e-16 550538017915 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 550538017916 active pocket/dimerization site; other site 550538017917 active site 550538017918 phosphorylation site [posttranslational modification] 550538017919 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 2.7e-14 550538017920 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 550538017921 active site 550538017922 phosphorylation site [posttranslational modification] 550538017923 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 1e-30 550538017924 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 550538017925 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 5.9e-40 550538017926 5 probable transmembrane helices predicted for SG3658 by TMHMM2.0 at aa 21-43, 93-110, 141-163, 183-203 and 210-232 550538017927 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 550538017928 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 2e-81 550538017929 5 probable transmembrane helices predicted for SG3659 by TMHMM2.0 at aa 128-147, 151-173, 197-216, 236-258 and 265-284 550538017930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 550538017931 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 1.7e-09 550538017932 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538017933 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 550538017934 HMMPfam hit to PF07071, Protein of unknown function DUF1341, score 1.3e-165 550538017935 hypothetical protein; Provisional; Region: PRK09956 550538017936 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 550538017937 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 1.2e-205 550538017939 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 4.9e-20 550538017940 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.5e-16 550538017941 Salmonella pathogenicity island 3; SPI-3 550538017942 magnesium transport protein MgtC; Provisional; Region: PRK15385 550538017943 MgtC family; Region: MgtC; pfam02308 550538017944 4 probable transmembrane helices predicted for SG3665 by TMHMM2.0 at aa 5-27, 34-56, 66-83 and 90-112 550538017945 HMMPfam hit to PF02308, MgtC/SapB transporter, score 1.6e-76 550538017946 magnesium-transporting ATPase; Provisional; Region: PRK15122 550538017947 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 550538017948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 550538017949 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 550538017950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538017951 motif II; other site 550538017952 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 550538017953 HMMPfam hit to PF00690, ATPase, P-type cation-transporter, N-terminal, score 1.1e-22 550538017954 8 probable transmembrane helices predicted for SG3666 by TMHMM2.0 at aa 87-105, 115-134, 293-315, 325-347, 719-741, 779-801, 844-866 and 876-893 550538017955 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 1.6e-86 550538017956 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.8e-19 550538017957 PS00154 E1-E2 ATPases phosphorylation site. 550538017958 Isochorismatase family; Region: Isochorismatase; pfam00857 550538017959 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 550538017960 catalytic triad [active] 550538017961 dimer interface [polypeptide binding]; other site 550538017962 conserved cis-peptide bond; other site 550538017963 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 9.8e-19 550538017964 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 550538017965 DNA binding site [nucleotide binding] 550538017966 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3.4e-18 550538017967 1 probable transmembrane helix predicted for SG3669 by TMHMM2.0 at aa 147-169 550538017968 autotransport protein MisL; Provisional; Region: PRK15313 550538017969 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 550538017970 Autotransporter beta-domain; Region: Autotransporter; pfam03797 550538017971 HMMPfam hit to PF03797, Autotransporter beta-domain, score 7.4e-37 550538017972 HMMPfam hit to PF03212, Pertactin, score 0.00014 550538017973 1 probable transmembrane helix predicted for SG3671 by TMHMM2.0 at aa 7-29 550538017974 the sequence has been checked and is believed to be correct 550538017976 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.4e-08 550538017977 Virulence protein [General function prediction only]; Region: COG3943 550538017978 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 550538017980 HMMPfam hit to PF02463, SMC protein, N-terminal, score 2.3e-05 550538017982 putative alpha-glucosidase; Provisional; Region: PRK10658 550538017983 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 550538017984 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 550538017985 active site 550538017986 homotrimer interface [polypeptide binding]; other site 550538017987 catalytic site [active] 550538017988 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 550538017989 HMMPfam hit to PF01055, Glycoside hydrolase, family 31, score 3.5e-182 550538017990 AsmA family; Region: AsmA; pfam05170 550538017991 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 550538017992 HMMPfam hit to PF05170, AsmA, score 2.9e-242 550538017993 1 probable transmembrane helix predicted for SG3684 by TMHMM2.0 at aa 7-26 550538017994 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 550538017995 11 probable transmembrane helices predicted for SG3685 by TMHMM2.0 at aa 43-65, 90-112, 127-149, 156-178, 193-212, 219-241, 261-283, 346-368, 378-400, 407-429 and 439-458 550538017996 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 2.1e-158 550538017997 PS01116 Xanthine/uracil permeases family signature. 550538017998 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 550538017999 HMMPfam hit to PF03616, Sodium/glutamate symporter, score 3.2e-246 550538018000 9 probable transmembrane helices predicted for SG3686 by TMHMM2.0 at aa 70-87, 94-116, 157-179, 213-235, 245-267, 274-292, 302-324, 336-358 and 368-390 550538018001 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 550538018002 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 550538018003 generic binding surface II; other site 550538018004 ssDNA binding site; other site 550538018005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 550538018006 ATP binding site [chemical binding]; other site 550538018007 putative Mg++ binding site [ion binding]; other site 550538018008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 550538018009 nucleotide binding region [chemical binding]; other site 550538018010 ATP-binding site [chemical binding]; other site 550538018011 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 8.4e-25 550538018012 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 1.1e-34 550538018013 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018014 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 2.2e-11 550538018015 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 550538018016 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 550538018017 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 550538018018 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 2e-53 550538018019 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 550538018020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 550538018021 Zn2+ binding site [ion binding]; other site 550538018022 Mg2+ binding site [ion binding]; other site 550538018023 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 550538018024 synthetase active site [active] 550538018025 NTP binding site [chemical binding]; other site 550538018026 metal binding site [ion binding]; metal-binding site 550538018027 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 550538018028 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 550538018029 HMMPfam hit to PF02824, TGS, score 2.1e-28 550538018030 HMMPfam hit to PF04607, RelA/SpoT, score 1.5e-45 550538018031 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 6.5e-20 550538018032 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 550538018033 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 3.8e-23 550538018034 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 550538018035 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 550538018036 catalytic site [active] 550538018037 G-X2-G-X-G-K; other site 550538018038 HMMPfam hit to PF00625, Guanylate kinase, score 4.4e-63 550538018039 PS00856 Guanylate kinase signature. 550538018040 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018041 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 550538018042 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 550538018043 nucleotide binding pocket [chemical binding]; other site 550538018044 K-X-D-G motif; other site 550538018045 catalytic site [active] 550538018046 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 550538018047 HMMPfam hit to PF01653, NAD-dependent DNA ligase, adenylation, score 2.5e-80 550538018048 PS01055 NAD-dependent DNA ligase signature 1. 550538018049 HMMPfam hit to PF03120, NAD-dependent DNA ligase, OB-fold, score 2.9e-24 550538018050 PS01056 NAD-dependent DNA ligase signature 2. 550538018051 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538018052 Predicted membrane protein [Function unknown]; Region: COG2860 550538018053 UPF0126 domain; Region: UPF0126; pfam03458 550538018054 UPF0126 domain; Region: UPF0126; pfam03458 550538018055 7 probable transmembrane helices predicted for SG3693 by TMHMM2.0 at aa 5-22, 29-51, 64-81, 88-109, 114-136, 148-167 and 172-189 550538018056 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 4.3e-34 550538018057 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 8.8e-37 550538018058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 550538018059 HMMPfam hit to PF00753, Beta-lactamase-like, score 6.6e-15 550538018060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538018061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538018062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 550538018063 dimerization interface [polypeptide binding]; other site 550538018064 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.9e-10 550538018065 PS00044 Bacterial regulatory proteins, lysR family signature. 550538018066 HMMPfam hit to PF03466, LysR, substrate-binding, score 5.1e-07 550538018067 hypothetical protein; Provisional; Region: PRK11820 550538018068 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 550538018069 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 550538018070 HMMPfam hit to PF08340, Region of unknown function DUF1732, score 7.5e-57 550538018071 HMMPfam hit to PF03755, YicC-like, N-terminal, score 1.9e-86 550538018072 ribonuclease PH; Reviewed; Region: rph; PRK00173 550538018073 Ribonuclease PH; Region: RNase_PH_bact; cd11362 550538018074 hexamer interface [polypeptide binding]; other site 550538018075 active site 550538018076 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 1.7e-56 550538018077 PS01277 Ribonuclease PH signature. 550538018078 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 2.2e-23 550538018079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538018080 active site 550538018081 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 6.7e-33 550538018082 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538018083 division inhibitor protein; Provisional; Region: slmA; PRK09480 550538018084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538018085 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2e-11 550538018086 PS01081 Bacterial regulatory proteins, tetR family signature. 550538018087 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 550538018088 trimer interface [polypeptide binding]; other site 550538018089 active site 550538018090 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 1.4e-55 550538018091 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 550538018092 Flavoprotein; Region: Flavoprotein; pfam02441 550538018093 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 550538018094 HMMPfam hit to PF04127, DNA/pantothenate metabolism flavoprotein, C-terminal, score 3.8e-35 550538018095 HMMPfam hit to PF02441, Flavoprotein, score 6.2e-48 550538018096 hypothetical protein; Reviewed; Region: PRK00024 550538018097 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 550538018098 MPN+ (JAMM) motif; other site 550538018099 Zinc-binding site [ion binding]; other site 550538018100 HMMPfam hit to PF04002, DNA repair protein RadC, score 6.4e-82 550538018101 PS01302 DNA repair protein radC family signature. 550538018102 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 550538018103 HMMPfam hit to PF00830, Ribosomal protein L28, score 8.1e-35 550538018104 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 550538018105 HMMPfam hit to PF00471, Ribosomal protein L33, score 1.5e-24 550538018106 PS00582 Ribosomal protein L33 signature. 550538018107 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 550538018108 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 550538018109 DNA binding site [nucleotide binding] 550538018110 catalytic residue [active] 550538018111 H2TH interface [polypeptide binding]; other site 550538018112 putative catalytic residues [active] 550538018113 turnover-facilitating residue; other site 550538018114 intercalation triad [nucleotide binding]; other site 550538018115 8OG recognition residue [nucleotide binding]; other site 550538018116 putative reading head residues; other site 550538018117 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 550538018118 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 550538018119 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase, catalytic, score 3.2e-47 550538018120 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, H2TH DNA binding, score 1.3e-51 550538018121 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 0.00056 550538018122 PS01242 Formamidopyrimidine-DNA glycosylase signature. 550538018123 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 550538018124 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 550538018125 active site 550538018126 (T/H)XGH motif; other site 550538018127 HMMPfam hit to PF01467, Cytidylyltransferase, score 2.1e-39 550538018128 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 550538018129 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 550538018130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 550538018131 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 9e-08 550538018132 HMMPfam hit to PF04413, Three-deoxy-D-manno-octulosonic-acid transferase, N-terminal, score 1.8e-115 550538018133 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 550538018134 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 550538018135 putative active site [active] 550538018136 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 8e-84 550538018137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 550538018138 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 550538018139 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538018140 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.5e-37 550538018141 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 550538018142 HMMPfam hit to PF06293, Lipopolysaccharide kinase, score 6.3e-88 550538018143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 550538018144 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 550538018145 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 550538018146 putative ADP-binding pocket [chemical binding]; other site 550538018147 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 7.1e-37 550538018148 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 550538018149 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 550538018150 Ligand binding site; other site 550538018151 metal-binding site 550538018152 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 550538018153 HMMPfam hit to PF01501, Glycosyl transferase, family 8, score 2.5e-87 550538018154 HMMPfam hit to PF08437, Glycosyl transferase, family 8, C-terminal, score 7e-34 550538018155 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 550538018156 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 550538018157 Ligand binding site; other site 550538018158 metal-binding site 550538018159 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 550538018160 PS00430 TonB-dependent receptor proteins signature 1. 550538018161 HMMPfam hit to PF01501, Glycosyl transferase, family 8, score 2.7e-87 550538018162 HMMPfam hit to PF08437, Glycosyl transferase, family 8, C-terminal, score 3.6e-32 550538018163 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 550538018164 HMMPfam hit to PF06176, Lipopolysaccharide core biosynthesis, score 7e-189 550538018165 the sequence has been checked and is believed to be correct 550538018166 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 550538018167 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 550538018168 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 3.7e-54 550538018169 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 550538018170 O-antigen ligase RfaL; Provisional; Region: PRK15487 550538018171 10 probable transmembrane helices predicted for SG3718 by TMHMM2.0 at aa 21-53, 68-85, 126-145, 160-182, 189-206, 210-225, 230-247, 325-347, 360-379 and 383-401 550538018172 HMMPfam hit to PF04932, O-antigen polymerase, score 3e-19 550538018173 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 550538018174 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 550538018175 putative active site [active] 550538018176 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 6.9e-119 550538018177 PS00974 Mannitol dehydrogenases signature. 550538018178 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 550538018179 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 550538018180 putative active site [active] 550538018181 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 1.1e-117 550538018182 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 550538018183 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 550538018184 NADP binding site [chemical binding]; other site 550538018185 homopentamer interface [polypeptide binding]; other site 550538018186 substrate binding site [chemical binding]; other site 550538018187 active site 550538018188 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 2.2e-51 550538018189 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 550538018190 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 550538018191 substrate-cofactor binding pocket; other site 550538018192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538018193 catalytic residue [active] 550538018194 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.9e-113 550538018195 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 550538018196 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 550538018197 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 550538018198 NAD(P) binding site [chemical binding]; other site 550538018199 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.2e-46 550538018200 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538018201 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 6.6e-38 550538018202 putative glycosyl transferase; Provisional; Region: PRK10073 550538018203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 550538018204 active site 550538018205 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 5.8e-41 550538018206 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 550538018207 NodB motif; other site 550538018208 putative active site [active] 550538018209 putative catalytic site [active] 550538018210 Zn binding site [ion binding]; other site 550538018211 HMMPfam hit to PF04748, Protein of unknown function DUF610, YibQ, score 8e-119 550538018212 1 probable transmembrane helix predicted for SG3725 by TMHMM2.0 at aa 7-29 550538018213 AmiB activator; Provisional; Region: PRK11637 550538018214 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 550538018215 Peptidase family M23; Region: Peptidase_M23; pfam01551 550538018216 HMMPfam hit to PF01551, Peptidase M23B, score 6.1e-48 550538018217 1 probable transmembrane helix predicted for SG3726 by TMHMM2.0 at aa 20-42 550538018218 phosphoglyceromutase; Provisional; Region: PRK05434 550538018219 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 550538018220 HMMPfam hit to PF01676, Metalloenzyme, score 5.7e-58 550538018221 HMMPfam hit to PF06415, BPG-independent PGAM, N-terminal, score 3.1e-255 550538018222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 550538018223 active site residue [active] 550538018224 1 probable transmembrane helix predicted for SG3728 by TMHMM2.0 at aa 7-29 550538018225 HMMPfam hit to PF00581, Rhodanese-like, score 2e-22 550538018226 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 550538018227 GSH binding site [chemical binding]; other site 550538018228 catalytic residues [active] 550538018229 HMMPfam hit to PF00462, Glutaredoxin, score 6.3e-29 550538018230 PS00195 Glutaredoxin active site. 550538018231 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 550538018232 SecA binding site; other site 550538018233 Preprotein binding site; other site 550538018234 HMMPfam hit to PF02556, Bacterial protein export chaperone SecB, score 1.2e-101 550538018235 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 550538018236 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 550538018237 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 550538018238 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal, score 1.2e-81 550538018239 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal, score 2e-80 550538018240 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 550538018241 serine acetyltransferase; Provisional; Region: cysE; PRK11132 550538018242 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 550538018243 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 550538018244 trimer interface [polypeptide binding]; other site 550538018245 active site 550538018246 substrate binding site [chemical binding]; other site 550538018247 CoA binding site [chemical binding]; other site 550538018248 HMMPfam hit to PF06426, Serine acetyltransferase, N-terminal, score 8.8e-66 550538018249 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.2e+02 550538018250 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.93 550538018251 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.9 550538018252 PS00101 Hexapeptide-repeat containing-transferases signature. 550538018253 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.2 550538018254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538018255 D-galactonate transporter; Region: 2A0114; TIGR00893 550538018256 putative substrate translocation pore; other site 550538018257 12 probable transmembrane helices predicted for SG3733 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-127, 140-162, 172-189, 240-262, 277-299, 311-333, 338-360, 372-394 and 404-426 550538018258 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.1e-55 550538018259 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 550538018260 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 550538018261 active site pocket [active] 550538018262 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 3e-39 550538018263 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 550538018264 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 1.3e-08 550538018265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 550538018266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538018267 DNA binding site [nucleotide binding] 550538018268 domain linker motif; other site 550538018269 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 550538018270 putative dimerization interface [polypeptide binding]; other site 550538018271 putative ligand binding site [chemical binding]; other site 550538018272 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4.3e-09 550538018273 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 5.1e-11 550538018274 putative rRNA methylase; Provisional; Region: PRK10358 550538018275 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 1.2e-43 550538018276 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 550538018277 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 550538018278 active site 550538018279 substrate binding site [chemical binding]; other site 550538018280 FMN binding site [chemical binding]; other site 550538018281 putative catalytic residues [active] 550538018282 HMMPfam hit to PF01070, FMN-dependent alpha-hydroxy acid dehydrogenase, score 1.6e-226 550538018283 PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 550538018284 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 550538018285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538018286 DNA-binding site [nucleotide binding]; DNA binding site 550538018287 FCD domain; Region: FCD; pfam07729 550538018288 HMMPfam hit to PF07729, GntR, C-terminal, score 4.7e-40 550538018289 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.3e-26 550538018290 PS00043 Bacterial regulatory proteins, gntR family signature. 550538018292 HMMPfam hit to PF02652, L-lactate permease, score 0 550538018293 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 550538018294 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 550538018295 trimer interface [polypeptide binding]; other site 550538018296 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 550538018297 Haemagglutinin; Region: HIM; pfam05662 550538018298 Haemagglutinin; Region: HIM; pfam05662 550538018299 YadA-like C-terminal region; Region: YadA; pfam03895 550538018300 HMMPfam hit to PF03895, YadA-like, C-terminal, score 3.8e-42 550538018301 HMMPfam hit to PF05662, Haemagluttinin motif, score 5.9e-05 550538018302 HMMPfam hit to PF05662, Haemagluttinin motif, score 7.5e-09 550538018303 HMMPfam hit to PF05658, Hep/Hag, score 0.00012 550538018304 HMMPfam hit to PF05658, Hep/Hag, score 2 550538018305 HMMPfam hit to PF05662, Haemagluttinin motif, score 5.5e-08 550538018306 HMMPfam hit to PF05658, Hep/Hag, score 1.5e-05 550538018307 HMMPfam hit to PF05658, Hep/Hag, score 0.0002 550538018308 HMMPfam hit to PF05662, Haemagluttinin motif, score 2.1e-06 550538018309 HMMPfam hit to PF05658, Hep/Hag, score 5.1e-05 550538018310 HMMPfam hit to PF05662, Haemagluttinin motif, score 4.5e-08 550538018311 HMMPfam hit to PF05662, Haemagluttinin motif, score 9.2e-08 550538018312 HMMPfam hit to PF05662, Haemagluttinin motif, score 1.9e-08 550538018313 HMMPfam hit to PF05662, Haemagluttinin motif, score 7.8e-07 550538018314 HMMPfam hit to PF05662, Haemagluttinin motif, score 7.8e-07 550538018315 HMMPfam hit to PF05662, Haemagluttinin motif, score 7.8e-07 550538018316 HMMPfam hit to PF05662, Haemagluttinin motif, score 7.8e-07 550538018317 HMMPfam hit to PF05662, Haemagluttinin motif, score 5.8e-05 550538018318 HMMPfam hit to PF05658, Hep/Hag, score 1.3e-05 550538018319 HMMPfam hit to PF05658, Hep/Hag, score 9.7e-05 550538018320 HMMPfam hit to PF05658, Hep/Hag, score 4.9e-05 550538018321 HMMPfam hit to PF05658, Hep/Hag, score 0.00095 550538018322 HMMPfam hit to PF05658, Hep/Hag, score 0.93 550538018323 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 550538018324 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018325 hypothetical protein; Provisional; Region: PRK11020 550538018326 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 550538018327 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 550538018328 HMMPfam hit to PF05068, Mannitol repressor, score 1.5e-118 550538018329 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 550538018330 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 550538018331 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 550538018332 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 3.4e-114 550538018333 PS00974 Mannitol dehydrogenases signature. 550538018334 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 5.3e-51 550538018335 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 550538018336 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 550538018337 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 550538018338 active site 550538018339 P-loop; other site 550538018340 phosphorylation site [posttranslational modification] 550538018341 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538018342 active site 550538018343 phosphorylation site [posttranslational modification] 550538018344 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 1.1e-81 550538018345 PS00372 PTS EIIA domains phosphorylation site signature 2. 550538018346 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.1e-13 550538018347 8 probable transmembrane helices predicted for SG3745 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 129-151, 212-234, 244-263, 270-292 and 312-334 550538018348 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.5e-26 550538018349 putative glutathione S-transferase; Provisional; Region: PRK10357 550538018350 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 550538018351 putative C-terminal domain interface [polypeptide binding]; other site 550538018352 putative GSH binding site (G-site) [chemical binding]; other site 550538018353 putative dimer interface [polypeptide binding]; other site 550538018354 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 550538018355 dimer interface [polypeptide binding]; other site 550538018356 N-terminal domain interface [polypeptide binding]; other site 550538018357 putative substrate binding pocket (H-site) [chemical binding]; other site 550538018358 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 6.6e-06 550538018359 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 2.4e-19 550538018360 selenocysteine synthase; Provisional; Region: PRK04311 550538018361 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 550538018362 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 550538018363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 550538018364 catalytic residue [active] 550538018365 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 9.6e-272 550538018366 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 550538018367 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 550538018368 G1 box; other site 550538018369 putative GEF interaction site [polypeptide binding]; other site 550538018370 GTP/Mg2+ binding site [chemical binding]; other site 550538018371 Switch I region; other site 550538018372 G2 box; other site 550538018373 G3 box; other site 550538018374 Switch II region; other site 550538018375 G4 box; other site 550538018376 G5 box; other site 550538018377 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 550538018378 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 550538018379 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 550538018380 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 550538018381 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 3.8e-36 550538018382 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018383 PS00301 GTP-binding elongation factors signature. 550538018384 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3.6e-11 550538018385 HMMPfam hit to PF09106, Translation elongation factor SelB, winged helix, type 2, score 3.8e-22 550538018386 HMMPfam hit to PF09107, Translation elongation factor SelB, winged helix, type 3, score 1.8e-25 550538018387 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 550538018388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 550538018389 nucleotide binding site [chemical binding]; other site 550538018390 HMMPfam hit to PF00480, ROK, score 1.6e-36 550538018391 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 550538018392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 550538018393 NAD(P) binding site [chemical binding]; other site 550538018394 catalytic residues [active] 550538018395 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.7e-222 550538018396 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538018397 PS00070 Aldehyde dehydrogenases cysteine active site. 550538018398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 550538018399 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 550538018400 HMMPfam hit to PF07944, Protein of unknown function DUF1680, score 6.5e-275 550538018401 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 550538018402 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 550538018403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538018404 PS00041 Bacterial regulatory proteins, araC family signature. 550538018405 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.8e-09 550538018406 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 550538018407 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 550538018408 intersubunit interface [polypeptide binding]; other site 550538018409 active site 550538018410 Zn2+ binding site [ion binding]; other site 550538018411 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 3.6e-102 550538018412 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 550538018413 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 550538018414 AP (apurinic/apyrimidinic) site pocket; other site 550538018415 DNA interaction; other site 550538018416 Metal-binding active site; metal-binding site 550538018417 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 4.9e-47 550538018418 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538018419 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 550538018420 active site 550538018421 dimer interface [polypeptide binding]; other site 550538018422 magnesium binding site [ion binding]; other site 550538018423 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 1.6e-52 550538018425 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 1.5e-100 550538018426 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 2.3e-120 550538018427 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 550538018428 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 550538018429 HMMPfam hit to PF03480, TRAP dicarboxylate transporter- DctP subunit, score 2.7e-136 550538018430 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 550538018431 DctM-like transporters; Region: DctM; pfam06808 550538018432 11 probable transmembrane helices predicted for SG3759 by TMHMM2.0 at aa 4-26, 47-69, 93-124, 137-159, 169-191, 212-230, 234-256, 277-299, 314-347, 354-376 and 396-418 550538018433 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport system permease DctM subunit, score 1.2e-200 550538018434 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 550538018435 HMMPfam hit to PF04290, Tripartite ATP-independent periplasmic transporter, DctQ component, score 1.6e-45 550538018436 4 probable transmembrane helices predicted for SG3760 by TMHMM2.0 at aa 7-29, 44-66, 79-98 and 113-135 550538018437 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018438 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 550538018439 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 2.9e-77 550538018440 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 550538018441 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 1.8e-193 550538018442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 550538018443 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 550538018444 Bacterial transcriptional regulator; Region: IclR; pfam01614 550538018445 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 8.4e-30 550538018446 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 2.8e-56 550538018447 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 550538018448 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 8.1e-07 550538018449 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538018450 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 550538018451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538018452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538018453 homodimer interface [polypeptide binding]; other site 550538018454 catalytic residue [active] 550538018455 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 4.7e-10 550538018457 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 8.6e-84 550538018458 hypothetical protein; Provisional; Region: PRK10356 550538018459 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 550538018460 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 0.00044 550538018461 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 550538018462 putative dimerization interface [polypeptide binding]; other site 550538018463 Transcriptional regulators [Transcription]; Region: PurR; COG1609 550538018464 putative ligand binding site [chemical binding]; other site 550538018465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538018466 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 550538018467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538018468 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.8e-12 550538018469 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9.5e-11 550538018470 xylose isomerase; Provisional; Region: PRK05474 550538018471 xylose isomerase; Region: xylose_isom_A; TIGR02630 550538018472 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 6.8e-11 550538018473 PS00173 Xylose isomerase signature 2. 550538018474 PS00172 Xylose isomerase signature 1. 550538018475 xylulokinase; Provisional; Region: PRK15027 550538018476 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 550538018477 N- and C-terminal domain interface [polypeptide binding]; other site 550538018478 active site 550538018479 MgATP binding site [chemical binding]; other site 550538018480 catalytic site [active] 550538018481 metal binding site [ion binding]; metal-binding site 550538018482 xylulose binding site [chemical binding]; other site 550538018483 homodimer interface [polypeptide binding]; other site 550538018484 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1.6e-118 550538018485 PS00933 FGGY family of carbohydrate kinases signature 1. 550538018486 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 4e-107 550538018487 PS00445 FGGY family of carbohydrate kinases signature 2. 550538018488 Predicted membrane protein [Function unknown]; Region: COG4682 550538018489 yiaA/B two helix domain; Region: YiaAB; pfam05360 550538018490 yiaA/B two helix domain; Region: YiaAB; pfam05360 550538018491 HMMPfam hit to PF05360, YiaAB two helix, score 9.3e-22 550538018492 3 probable transmembrane helices predicted for SG3773 by TMHMM2.0 at aa 12-29, 39-54 and 71-105 550538018493 HMMPfam hit to PF05360, YiaAB two helix, score 2e-18 550538018494 the sequence has been checked and is believed to be correct 550538018495 HMMPfam hit to PF01757, Acyltransferase 3, score 0.00016 550538018496 YsaB-like lipoprotein; Region: YsaB; pfam13983 550538018497 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018498 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 550538018499 dimer interface [polypeptide binding]; other site 550538018500 motif 1; other site 550538018501 active site 550538018502 motif 2; other site 550538018503 motif 3; other site 550538018504 HMMPfam hit to PF02091, Glycyl-tRNA synthetase, class IIc, alpha subunit, score 1.8e-249 550538018505 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538018506 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 550538018507 DALR anticodon binding domain; Region: DALR_1; pfam05746 550538018508 HMMPfam hit to PF02092, Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal, score 0 550538018509 HMMPfam hit to PF05746, DALR anticodon binding, score 6.9e-05 550538018511 Integrase core domain; Region: rve; pfam00665 550538018512 Integrase core domain; Region: rve_2; pfam13333 550538018513 HMMPfam hit to PF00665, Integrase, catalytic core, score 3.2e-10 550538018514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 550538018515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538018516 Coenzyme A binding pocket [chemical binding]; other site 550538018517 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.4e-11 550538018518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 550538018519 HMMPfam hit to PF08681, Protein of unknown function DUF1778, score 2.8e-26 550538018520 the sequence has been checked and is believed to be correct 550538018521 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 550538018522 DNA-binding site [nucleotide binding]; DNA binding site 550538018523 RNA-binding motif; other site 550538018524 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 3.2e-44 550538018525 PS00352 'Cold-shock' DNA-binding domain signature. 550538018526 Predicted transcriptional regulator [Transcription]; Region: COG2944 550538018527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538018528 salt bridge; other site 550538018529 non-specific DNA binding site [nucleotide binding]; other site 550538018530 sequence-specific DNA binding site [nucleotide binding]; other site 550538018531 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 550538018532 1 probable transmembrane helix predicted for SG3786 by TMHMM2.0 at aa 10-27 550538018533 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018534 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 550538018535 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 550538018536 dimerization interface [polypeptide binding]; other site 550538018537 ligand binding site [chemical binding]; other site 550538018538 NADP binding site [chemical binding]; other site 550538018539 catalytic site [active] 550538018540 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 2.8e-38 550538018541 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 6.4e-86 550538018542 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 550538018543 putative outer membrane lipoprotein; Provisional; Region: PRK10510 550538018544 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 550538018545 ligand binding site [chemical binding]; other site 550538018546 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 5.6e-46 550538018547 PS01068 OmpA-like domain. 550538018548 2 probable transmembrane helices predicted for SG3788 by TMHMM2.0 at aa 25-44 and 51-73 550538018549 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 2.9e-10 550538018550 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018551 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 550538018552 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 550538018553 molybdopterin cofactor binding site [chemical binding]; other site 550538018554 substrate binding site [chemical binding]; other site 550538018555 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 550538018556 molybdopterin cofactor binding site; other site 550538018557 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.3e-180 550538018558 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018559 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 1.1e-29 550538018560 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538018561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538018562 Coenzyme A binding pocket [chemical binding]; other site 550538018563 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3e-16 550538018564 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 550538018565 HMMPfam hit to PF03352, Methyladenine glycosylase, score 2.4e-128 550538018566 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 550538018567 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018568 1 probable transmembrane helix predicted for SG3792 by TMHMM2.0 at aa 12-31 550538018569 HMMPfam hit to PF03797, Autotransporter beta-domain, score 5e-05 550538018570 fimbrial operon lpf 550538018571 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 550538018572 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 6.2e-68 550538018573 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 550538018574 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538018575 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538018576 1 probable transmembrane helix predicted for SG3794 by TMHMM2.0 at aa 7-29 550538018577 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1e-71 550538018578 PS00635 Gram-negative pili assembly chaperone signature. 550538018579 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.1e-27 550538018581 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538018582 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 550538018583 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0098 550538018584 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 550538018585 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1e-10 550538018586 phosphoethanolamine transferase; Provisional; Region: PRK11560 550538018587 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 550538018588 Sulfatase; Region: Sulfatase; pfam00884 550538018589 5 probable transmembrane helices predicted for SG3799 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-140 and 161-178 550538018590 HMMPfam hit to PF08019, Protein of unknown function DUF1705, score 9.1e-09 550538018591 HMMPfam hit to PF00884, Sulphatase, score 7.2e-74 550538018592 the sequence has been checked and is believed to be correct 550538018593 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 0.00028 550538018594 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 5.9e-07 550538018595 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 550538018596 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 550538018597 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 3e-39 550538018598 13 probable transmembrane helices predicted for SG3802 by TMHMM2.0 at aa 20-42, 47-69, 76-98, 103-125, 132-154, 169-191, 196-218, 233-255, 287-309, 319-341, 348-370, 380-402 and 409-431 550538018599 the sequence has been checked and is believed to be correct 550538018600 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 5.9e-95 550538018601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 550538018602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538018603 dimer interface [polypeptide binding]; other site 550538018604 conserved gate region; other site 550538018605 putative PBP binding loops; other site 550538018606 ABC-ATPase subunit interface; other site 550538018607 5 probable transmembrane helices predicted for SG3804 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 202-221 and 258-280 550538018608 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.7e-39 550538018609 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538018610 dipeptide transporter; Provisional; Region: PRK10913 550538018611 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 550538018612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538018613 dimer interface [polypeptide binding]; other site 550538018614 conserved gate region; other site 550538018615 putative PBP binding loops; other site 550538018616 ABC-ATPase subunit interface; other site 550538018617 5 probable transmembrane helices predicted for SG3805 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287 550538018618 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.4e-47 550538018620 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-62 550538018621 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 1.8e-26 550538018622 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 550538018623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 550538018624 Walker A/P-loop; other site 550538018625 ATP binding site [chemical binding]; other site 550538018626 Q-loop/lid; other site 550538018627 ABC transporter signature motif; other site 550538018628 Walker B; other site 550538018629 D-loop; other site 550538018630 H-loop/switch region; other site 550538018631 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 550538018632 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-59 550538018633 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018634 PS00211 ABC transporters family signature. 550538018635 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 1.8e-32 550538018636 the sequence has been checked and is believed to be correct 550538018638 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 6.6e-23 550538018640 the sequence has been checked and is believed to be correct 550538018641 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 550538018642 1 probable transmembrane helix predicted for SG3813 by TMHMM2.0 at aa 7-29 550538018643 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 550538018644 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 550538018645 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 550538018646 the sequence has been checked and is believed to be correct 550538018647 HMMPfam hit to PF06564, YhjQ, score 6.1e-149 550538018648 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 550538018649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 550538018650 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 550538018651 DXD motif; other site 550538018652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 550538018653 PilZ domain; Region: PilZ; pfam07238 550538018654 10 probable transmembrane helices predicted for SG3817 by TMHMM2.0 at aa 28-50, 150-169, 173-190, 197-216, 229-251, 522-541, 545-567, 588-610, 633-655 and 668-690 550538018655 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018656 PS00215 Mitochondrial energy transfer proteins signature. 550538018657 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.1e-25 550538018658 HMMPfam hit to PF07238, Type IV pilus assembly PilZ, score 4.1e-21 550538018659 cellulose synthase regulator protein; Provisional; Region: PRK11114 550538018660 2 probable transmembrane helices predicted for SG3818 by TMHMM2.0 at aa 7-29 and 728-750 550538018661 HMMPfam hit to PF03170, Cellulose synthase, subunit B, score 3.2e-299 550538018662 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 550538018663 endo-1,4-D-glucanase; Provisional; Region: PRK11097 550538018664 HMMPfam hit to PF01270, Glycoside hydrolase, family 8, score 6.3e-143 550538018665 1 probable transmembrane helix predicted for SG3819 by TMHMM2.0 at aa 7-29 550538018666 PS00812 Glycosyl hydrolases family 8 signature. 550538018667 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 550538018668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 550538018669 TPR motif; other site 550538018670 binding surface 550538018671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 550538018672 TPR motif; other site 550538018673 binding surface 550538018674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 550538018675 binding surface 550538018676 TPR motif; other site 550538018677 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 550538018678 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 5e-05 550538018679 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.11 550538018680 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.14 550538018681 HMMPfam hit to PF07721, Tetratricopeptide TPR-4, score 0.025 550538018682 HMMPfam hit to PF05420, Cellulose synthase operon C, C-terminal, score 1.1e-172 550538018683 putative diguanylate cyclase; Provisional; Region: PRK13561 550538018684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538018685 metal binding site [ion binding]; metal-binding site 550538018686 active site 550538018687 I-site; other site 550538018688 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538018689 1 probable transmembrane helix predicted for SG3821 by TMHMM2.0 at aa 127-149 550538018690 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 8.9e-08 550538018691 HMMPfam hit to PF00990, GGDEF, score 1e-06 550538018692 HMMPfam hit to PF00563, EAL, score 8.4e-114 550538018693 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 550538018694 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 550538018695 9 probable transmembrane helices predicted for SG3822 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163, 184-206, 216-238, 289-311, 326-348 and 353-375 550538018696 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 2.9e-211 550538018697 PS00713 Sodium:dicarboxylate symporter family signature 1. 550538018698 PS00714 Sodium:dicarboxylate symporter family signature 2. 550538018699 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 550538018700 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 550538018701 HMMPfam hit to PF00675, Peptidase M16, N-terminal, score 0.024 550538018702 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538018703 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 7.4e-25 550538018704 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538018705 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 550538018706 substrate binding site [chemical binding]; other site 550538018707 ATP binding site [chemical binding]; other site 550538018708 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.3e-83 550538018709 PS00584 pfkB family of carbohydrate kinases signature 2. 550538018710 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 550538018711 HMMPfam hit to PF00563, EAL, score 2.2e-40 550538018712 the sequence has been checked and is believed to be correct 550538018713 HMMPfam hit to PF05170, AsmA, score 2.6e-220 550538018714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538018715 metabolite-proton symporter; Region: 2A0106; TIGR00883 550538018716 putative substrate translocation pore; other site 550538018717 HMMPfam hit to PF00083, General substrate transporter, score 3e-20 550538018718 11 probable transmembrane helices predicted for SG3827 by TMHMM2.0 at aa 32-54, 69-88, 109-131, 166-188, 195-217, 247-269, 290-312, 322-341, 348-370, 380-402 and 409-431 550538018719 PS00216 Sugar transport proteins signature 1. 550538018720 PS00359 Ribosomal protein L11 signature. 550538018721 inner membrane protein YhjD; Region: TIGR00766 550538018722 HMMPfam hit to PF03631, Ribonuclease BN, score 5.3e-27 550538018723 6 probable transmembrane helices predicted for SG3828 by TMHMM2.0 at aa 80-102, 135-157, 191-213, 233-255, 267-289 and 304-326 550538018724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538018725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538018726 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 550538018727 putative effector binding pocket; other site 550538018728 putative dimerization interface [polypeptide binding]; other site 550538018729 HMMPfam hit to PF03466, LysR, substrate-binding, score 3e-40 550538018730 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-17 550538018731 PS00044 Bacterial regulatory proteins, lysR family signature. 550538018733 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.5e-25 550538018734 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 550538018735 catalytic residue [active] 550538018736 1 probable transmembrane helix predicted for SG3833 by TMHMM2.0 at aa 337-359 550538018737 trehalase; Provisional; Region: treF; PRK13270 550538018738 Trehalase; Region: Trehalase; pfam01204 550538018739 HMMPfam hit to PF01204, Glycoside hydrolase, family 37, score 1.7e-252 550538018740 PS00928 Trehalase signature 2. 550538018741 PS00927 Trehalase signature 1. 550538018742 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 550538018743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538018744 DNA-binding site [nucleotide binding]; DNA binding site 550538018745 UTRA domain; Region: UTRA; pfam07702 550538018746 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 5.7e-28 550538018747 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.1e-37 550538018748 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 550538018749 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 550538018750 putative active site [active] 550538018751 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 550538018752 dimer interface [polypeptide binding]; other site 550538018753 active site 550538018754 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.3e-07 550538018755 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 7.9e-18 550538018756 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 550538018757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538018758 substrate binding site [chemical binding]; other site 550538018759 ATP binding site [chemical binding]; other site 550538018760 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.6e-08 550538018761 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018762 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 550538018763 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 550538018764 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter, score 3.6e-180 550538018765 11 probable transmembrane helices predicted for SG3838 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 163-185, 227-249, 264-281, 294-316, 331-350, 357-374, 379-398 and 419-438 550538018766 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 550538018767 active site 550538018768 homodimer interface [polypeptide binding]; other site 550538018769 homotetramer interface [polypeptide binding]; other site 550538018770 1 probable transmembrane helix predicted for SG3839 by TMHMM2.0 at aa 7-29 550538018771 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 4.5e-130 550538018772 PS00144 Asparaginase / glutaminase active site signature 1. 550538018773 PS00917 Asparaginase / glutaminase active site signature 2. 550538018774 glutathione reductase; Validated; Region: PRK06116 550538018775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538018776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538018777 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 550538018778 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 3.1e-53 550538018779 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2e-68 550538018780 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 5e-32 550538018781 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 550538018782 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 550538018783 HMMPfam hit to PF04378, Protein of unknown function DUF519, score 1.3e-169 550538018784 PS00092 N-6 Adenine-specific DNA methylases signature. 550538018785 PS00092 N-6 Adenine-specific DNA methylases signature. 550538018786 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 550538018787 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 550538018788 active site 550538018789 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 2.1e-09 550538018790 oligopeptidase A; Provisional; Region: PRK10911 550538018791 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 550538018792 active site 550538018793 Zn binding site [ion binding]; other site 550538018794 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 5.8e-246 550538018795 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 550538018796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538018797 S-adenosylmethionine binding site [chemical binding]; other site 550538018798 HMMPfam hit to PF04445, Protein of unknown function DUF548, score 2.8e-171 550538018799 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 550538018800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538018801 putative substrate translocation pore; other site 550538018802 POT family; Region: PTR2; pfam00854 550538018803 14 probable transmembrane helices predicted for SG3845 by TMHMM2.0 at aa 20-42, 52-74, 83-102, 107-124, 145-167, 171-193, 214-233, 237-255, 268-290, 314-336, 349-371, 386-408, 415-437 and 457-479 550538018804 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538018805 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 7.7e-110 550538018806 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 550538018807 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 550538018808 Ligand Binding Site [chemical binding]; other site 550538018809 HMMPfam hit to PF00582, UspA, score 6e-17 550538018810 universal stress protein UspB; Provisional; Region: PRK04960 550538018811 2 probable transmembrane helices predicted for SG3847 by TMHMM2.0 at aa 5-24 and 90-109 550538018812 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 550538018813 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 550538018814 8 probable transmembrane helices predicted for SG3848 by TMHMM2.0 at aa 13-35, 53-75, 82-104, 114-136, 166-183, 193-215, 339-361 and 431-453 550538018815 HMMPfam hit to PF01384, Phosphate transporter, score 7.7e-115 550538018816 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538018817 Predicted flavoproteins [General function prediction only]; Region: COG2081 550538018818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 550538018819 HMMPfam hit to PF03486, HI0933-like protein, score 1.2e-246 550538018820 HlyD family secretion protein; Region: HlyD; pfam00529 550538018821 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538018822 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538018823 1 probable transmembrane helix predicted for SG3850 by TMHMM2.0 at aa 7-26 550538018824 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.2e-39 550538018825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 550538018826 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 550538018827 Walker A/P-loop; other site 550538018828 ATP binding site [chemical binding]; other site 550538018829 Q-loop/lid; other site 550538018830 ABC transporter signature motif; other site 550538018831 Walker B; other site 550538018832 D-loop; other site 550538018833 H-loop/switch region; other site 550538018834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 550538018835 Walker A/P-loop; other site 550538018836 ATP binding site [chemical binding]; other site 550538018837 Q-loop/lid; other site 550538018838 ABC transporter signature motif; other site 550538018839 Walker B; other site 550538018840 D-loop; other site 550538018841 H-loop/switch region; other site 550538018842 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 550538018843 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 550538018844 HMMPfam hit to PF00005, ABC transporter related, score 5.4e-45 550538018845 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018846 PS00211 ABC transporters family signature. 550538018847 HMMPfam hit to PF00005, ABC transporter related, score 8.6e-48 550538018848 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018849 5 probable transmembrane helices predicted for SG3851 by TMHMM2.0 at aa 560-582, 716-738, 771-793, 800-822 and 886-908 550538018850 HMMPfam hit to PF01061, ABC-2 type transporter, score 2.4e-14 550538018851 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 550538018852 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 550538018853 6 probable transmembrane helices predicted for SG3852 by TMHMM2.0 at aa 25-47, 174-196, 230-252, 256-278, 285-302 and 344-366 550538018854 HMMPfam hit to PF01061, ABC-2 type transporter, score 9e-31 550538018855 PS00890 ABC-2 type transport system integral membrane proteins signature. 550538018856 nickel responsive regulator; Provisional; Region: PRK02967 550538018857 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 550538018858 HMMPfam hit to PF08753, NikR C terminal nickel binding, score 7.8e-41 550538018859 HMMPfam hit to PF01402, CopG-like DNA-binding, score 6.7e-13 550538018860 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 550538018861 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 550538018862 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 0.0019 550538018863 PS00196 Type-1 copper (blue) proteins signature. 550538018864 Domain of unknown function DUF20; Region: UPF0118; pfam01594 550538018865 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 550538018866 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 2.1e-93 550538018867 8 probable transmembrane helices predicted for SG3855 by TMHMM2.0 at aa 13-35, 39-56, 63-85, 141-163, 192-214, 224-246, 253-275 and 295-317 550538018868 major facilitator superfamily transporter; Provisional; Region: PRK05122 550538018869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538018870 putative substrate translocation pore; other site 550538018871 12 probable transmembrane helices predicted for SG3856 by TMHMM2.0 at aa 19-41, 51-73, 85-107, 122-144, 151-173, 177-199, 220-242, 252-271, 278-300, 310-332, 339-361 and 366-388 550538018872 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.3e-22 550538018873 hypothetical protein; Provisional; Region: PRK11615 550538018874 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538018875 hypothetical protein; Provisional; Region: PRK11212 550538018876 6 probable transmembrane helices predicted for SG3858 by TMHMM2.0 at aa 13-35, 45-64, 71-93, 108-130, 142-164 and 179-201 550538018877 HMMPfam hit to PF02592, Protein of unknown function DUF165, score 1.9e-73 550538018878 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 550538018879 CPxP motif; other site 550538018880 HMMPfam hit to PF01206, SirA-like, score 4.9e-42 550538018881 PS01148 Uncharacterized protein family UPF0033 signature. 550538018882 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 550538018883 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 550538018884 dimer interface [polypeptide binding]; other site 550538018885 ligand binding site [chemical binding]; other site 550538018886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538018887 dimerization interface [polypeptide binding]; other site 550538018888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538018889 dimer interface [polypeptide binding]; other site 550538018890 putative CheW interface [polypeptide binding]; other site 550538018891 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 6.2e-121 550538018892 PS00538 Bacterial chemotaxis sensory transducers signature. 550538018893 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 4.8e-19 550538018894 2 probable transmembrane helices predicted for SG3860 by TMHMM2.0 at aa 10-32 and 195-217 550538018895 HMMPfam hit to PF02203, Ligand binding Tar, score 9.9e-60 550538018896 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 550538018897 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 550538018898 metal-binding site [ion binding] 550538018899 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 550538018900 PS00141 Eukaryotic and viral aspartyl proteases active site. 550538018901 5 probable transmembrane helices predicted for SG3861 by TMHMM2.0 at aa 147-169, 189-211, 350-372, 387-409 and 690-712 550538018902 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.7e-30 550538018903 PS01229 Hypothetical cof family signature 2. 550538018904 PS00154 E1-E2 ATPases phosphorylation site. 550538018905 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 5.4e-94 550538018906 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538018907 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538018908 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 5.7e-13 550538018909 PS01047 Heavy-metal-associated domain. 550538018910 Predicted membrane protein [Function unknown]; Region: COG3714 550538018911 HMMPfam hit to PF07947, YhhN-like, score 6.2e-61 550538018912 6 probable transmembrane helices predicted for SG3862 by TMHMM2.0 at aa 28-45, 50-72, 77-96, 101-123, 130-152 and 156-178 550538018913 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 550538018914 1 probable transmembrane helix predicted for SG3863 by TMHMM2.0 at aa 5-24 550538018915 hypothetical protein; Provisional; Region: PRK10910 550538018916 HMMPfam hit to PF06611, Protein of unknown function DUF1145, score 1.1e-38 550538018917 2 probable transmembrane helices predicted for SG3864 by TMHMM2.0 at aa 4-23 and 30-52 550538018918 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 550538018919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538018920 S-adenosylmethionine binding site [chemical binding]; other site 550538018921 HMMPfam hit to PF03602, Conserved hypothetical protein CHP00095, score 5.8e-92 550538018922 PS00092 N-6 Adenine-specific DNA methylases signature. 550538018923 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 550538018924 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 550538018925 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 550538018926 P loop; other site 550538018927 GTP binding site [chemical binding]; other site 550538018928 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 1.3e-19 550538018929 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 1.3e-127 550538018930 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018931 PS00300 SRP54-type proteins GTP-binding domain signature. 550538018932 cell division protein FtsE; Provisional; Region: PRK10908 550538018933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538018934 Walker A/P-loop; other site 550538018935 ATP binding site [chemical binding]; other site 550538018936 Q-loop/lid; other site 550538018937 ABC transporter signature motif; other site 550538018938 Walker B; other site 550538018939 D-loop; other site 550538018940 H-loop/switch region; other site 550538018941 HMMPfam hit to PF00005, ABC transporter related, score 5.8e-75 550538018942 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018943 PS00211 ABC transporters family signature. 550538018944 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 550538018945 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 550538018946 4 probable transmembrane helices predicted for SG3868 by TMHMM2.0 at aa 71-93, 223-245, 266-288 and 323-342 550538018947 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 3.2e-23 550538018948 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 550538018949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 550538018950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 550538018951 DNA binding residues [nucleotide binding] 550538018952 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 5.3e-22 550538018953 PS00715 Sigma-70 factors family signature 1. 550538018954 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1.2e-20 550538018955 PS00716 Sigma-70 factors family signature 2. 550538018956 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 550538018957 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 550538018958 dimerization interface [polypeptide binding]; other site 550538018959 ligand binding site [chemical binding]; other site 550538018960 HMMPfam hit to PF01094, Extracellular ligand-binding receptor, score 1.8e-71 550538018961 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 550538018962 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.00013 550538018963 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 550538018964 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 550538018965 dimerization interface [polypeptide binding]; other site 550538018966 ligand binding site [chemical binding]; other site 550538018967 HMMPfam hit to PF01094, Extracellular ligand-binding receptor, score 1e-73 550538018968 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 550538018969 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 550538018970 TM-ABC transporter signature motif; other site 550538018971 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 2.4e-70 550538018972 8 probable transmembrane helices predicted for SG3874 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124, 153-175, 207-229, 244-266 and 282-301 550538018973 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 550538018974 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 550538018975 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 550538018976 TM-ABC transporter signature motif; other site 550538018977 10 probable transmembrane helices predicted for SG3875 by TMHMM2.0 at aa 4-26, 47-66, 91-108, 120-142, 162-184, 193-210, 261-283, 315-337, 352-374 and 381-400 550538018978 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 5.9e-73 550538018979 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 550538018980 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 550538018981 Walker A/P-loop; other site 550538018982 ATP binding site [chemical binding]; other site 550538018983 Q-loop/lid; other site 550538018984 ABC transporter signature motif; other site 550538018985 Walker B; other site 550538018986 D-loop; other site 550538018987 H-loop/switch region; other site 550538018988 HMMPfam hit to PF00005, ABC transporter related, score 6.2e-55 550538018989 PS00017 ATP/GTP-binding site motif A (P-loop). 550538018990 PS00211 ABC transporters family signature. 550538018991 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 550538018992 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 550538018993 Walker A/P-loop; other site 550538018994 ATP binding site [chemical binding]; other site 550538018995 Q-loop/lid; other site 550538018996 ABC transporter signature motif; other site 550538018997 Walker B; other site 550538018998 D-loop; other site 550538018999 H-loop/switch region; other site 550538019000 HMMPfam hit to PF00005, ABC transporter related, score 9e-57 550538019001 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019002 PS00211 ABC transporters family signature. 550538019003 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 550538019004 HMMPfam hit to PF02604, Protein of unknown function DUF172, score 1.6e-11 550538019005 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 550538019006 HMMPfam hit to PF05012, Death-on-curing protein, score 9.1e-37 550538019007 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 550538019008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 550538019009 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 3.1e-34 550538019010 1 probable transmembrane helix predicted for SG3880 by TMHMM2.0 at aa 7-29 550538019011 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 550538019012 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 550538019013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538019014 dimer interface [polypeptide binding]; other site 550538019015 conserved gate region; other site 550538019016 putative PBP binding loops; other site 550538019017 ABC-ATPase subunit interface; other site 550538019018 6 probable transmembrane helices predicted for SG3881 by TMHMM2.0 at aa 12-34, 71-93, 106-128, 157-179, 206-228 and 266-288 550538019019 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.2e-19 550538019020 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538019021 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 550538019022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538019023 dimer interface [polypeptide binding]; other site 550538019024 conserved gate region; other site 550538019025 ABC-ATPase subunit interface; other site 550538019026 6 probable transmembrane helices predicted for SG3882 by TMHMM2.0 at aa 7-29, 82-104, 111-130, 145-162, 200-222 and 245-267 550538019027 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.2e-29 550538019028 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538019029 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 550538019030 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 550538019031 Walker A/P-loop; other site 550538019032 ATP binding site [chemical binding]; other site 550538019033 Q-loop/lid; other site 550538019034 ABC transporter signature motif; other site 550538019035 Walker B; other site 550538019036 D-loop; other site 550538019037 H-loop/switch region; other site 550538019038 TOBE domain; Region: TOBE_2; pfam08402 550538019039 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-59 550538019040 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019041 PS00211 ABC transporters family signature. 550538019042 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 4.3e-12 550538019043 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 550538019044 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 550538019045 putative active site [active] 550538019046 catalytic site [active] 550538019047 putative metal binding site [ion binding]; other site 550538019048 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 2.6e-67 550538019049 hypothetical protein; Provisional; Region: PRK10350 550538019050 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 550538019051 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 550538019052 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 2.2e-279 550538019053 PS00462 Gamma-glutamyltranspeptidase signature. 550538019054 the sequence has been checked and is believed to be correct 550538019055 HMMPfam hit to PF02126, Aryldialkylphosphatase, score 1.3e-36 550538019056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 550538019057 Protein of unknown function, DUF606; Region: DUF606; pfam04657 550538019058 10 probable transmembrane helices predicted for SG3888 by TMHMM2.0 at aa 7-26, 41-60, 80-97, 102-124, 137-156, 166-188, 201-223, 233-252, 257-276 and 286-308 550538019059 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 550538019060 HMMPfam hit to PF07090, Protein of unknown function DUF1355, score 1.5e-178 550538019061 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019062 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538019063 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538019064 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 550538019065 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 550538019066 substrate binding site [chemical binding]; other site 550538019067 dimer interface [polypeptide binding]; other site 550538019068 ATP binding site [chemical binding]; other site 550538019069 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 7.3e-78 550538019070 PS00584 pfkB family of carbohydrate kinases signature 2. 550538019071 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538019072 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 7.3e-15 550538019073 putative acetyltransferase YhhY; Provisional; Region: PRK10140 550538019074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538019075 Coenzyme A binding pocket [chemical binding]; other site 550538019076 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.5e-20 550538019077 putative oxidoreductase; Provisional; Region: PRK10206 550538019078 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 550538019079 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 550538019080 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.3e-33 550538019081 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019082 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 2.3e-19 550538019083 Pirin-related protein [General function prediction only]; Region: COG1741 550538019084 Pirin; Region: Pirin; pfam02678 550538019085 HMMPfam hit to PF02678, Pirin, N-terminal, score 1.9e-65 550538019086 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 550538019087 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538019088 DNA binding site [nucleotide binding] 550538019089 domain linker motif; other site 550538019090 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 550538019091 putative ligand binding site [chemical binding]; other site 550538019092 putative dimerization interface [polypeptide binding]; other site 550538019093 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.8e-10 550538019094 PS00356 Bacterial regulatory proteins, lacI family signature. 550538019095 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.1e-24 550538019096 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 550538019097 ATP-binding site [chemical binding]; other site 550538019098 Gluconate-6-phosphate binding site [chemical binding]; other site 550538019099 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019100 HMMPfam hit to PF01202, Shikimate kinase, score 2.1e-07 550538019101 low affinity gluconate transporter; Provisional; Region: PRK10472 550538019102 gluconate transporter; Region: gntP; TIGR00791 550538019103 HMMPfam hit to PF02447, Gluconate transporter, score 1.1e-257 550538019104 13 probable transmembrane helices predicted for SG3896 by TMHMM2.0 at aa 4-21, 28-47, 57-79, 104-126, 146-168, 175-197, 228-250, 262-284, 299-321, 328-350, 354-373, 386-408 and 423-445 550538019105 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 550538019106 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 550538019107 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 5.4e-35 550538019108 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 1.3e-84 550538019109 PS01103 Aspartate-semialdehyde dehydrogenase signature. 550538019111 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 6.9e-39 550538019112 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 6.8e-12 550538019113 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 6.9e-40 550538019114 glycogen debranching enzyme; Provisional; Region: PRK03705 550538019115 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 550538019116 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 550538019117 active site 550538019118 catalytic site [active] 550538019119 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 3.6e-29 550538019120 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 3.2e-11 550538019122 HMMPfam hit to PF00483, Nucleotidyl transferase, score 5.6e-98 550538019124 HMMPfam hit to PF08323, Starch synthase catalytic region, score 4.1e-125 550538019125 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 9.8e-08 550538019126 glycogen phosphorylase; Provisional; Region: PRK14986 550538019127 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 550538019128 homodimer interface [polypeptide binding]; other site 550538019129 active site pocket [active] 550538019130 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 0 550538019131 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 550538019132 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 550538019133 Transcriptional regulator [Transcription]; Region: IclR; COG1414 550538019134 Bacterial transcriptional regulator; Region: IclR; pfam01614 550538019135 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 8.8e-27 550538019136 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 1.6e-41 550538019137 PS01051 Bacterial regulatory proteins, iclR family signature. 550538019138 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 550538019139 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 550538019140 inhibitor site; inhibition site 550538019141 active site 550538019142 dimer interface [polypeptide binding]; other site 550538019143 catalytic residue [active] 550538019144 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 3.6e-75 550538019145 PS00666 Dihydrodipicolinate synthetase signature 2. 550538019146 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 550538019147 HMMPfam hit to PF00920, Dihydroxy-acid and 6-phosphogluconate dehydratase, score 2.7e-206 550538019148 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 550538019149 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 550538019150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538019151 D-galactonate transporter; Region: 2A0114; TIGR00893 550538019152 putative substrate translocation pore; other site 550538019153 12 probable transmembrane helices predicted for SG3909 by TMHMM2.0 at aa 13-30, 50-72, 85-104, 109-131, 144-166, 176-193, 239-261, 271-293, 305-324, 328-350, 363-385 and 395-417 550538019154 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.5e-69 550538019155 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 550538019156 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 550538019157 dimer interface [polypeptide binding]; other site 550538019158 active site 550538019159 metal binding site [ion binding]; metal-binding site 550538019160 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 8.8e-57 550538019161 PS00913 Iron-containing alcohol dehydrogenases signature 1. 550538019162 PS00060 Iron-containing alcohol dehydrogenases signature 2. 550538019163 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538019164 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 550538019165 5 probable transmembrane helices predicted for SG3911 by TMHMM2.0 at aa 25-56, 71-93, 106-125, 158-180 and 193-215 550538019166 hypothetical protein; Provisional; Region: PRK09781 550538019167 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 550538019168 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 550538019169 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.7e-71 550538019170 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 550538019171 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 550538019172 active site residue [active] 550538019173 HMMPfam hit to PF00581, Rhodanese-like, score 2.5e-20 550538019174 intramembrane serine protease GlpG; Provisional; Region: PRK10907 550538019175 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 550538019176 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 550538019177 6 probable transmembrane helices predicted for SG3915 by TMHMM2.0 at aa 98-120, 140-162, 169-188, 192-214, 223-245 and 250-272 550538019178 HMMPfam hit to PF01694, Peptidase S54, rhomboid, score 9.6e-46 550538019179 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 550538019180 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 550538019181 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538019182 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 5.2e-31 550538019183 PS00894 Bacterial regulatory proteins, deoR family signature. 550538019184 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.1e-84 550538019185 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 550538019186 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 550538019187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538019188 Walker A motif; other site 550538019189 ATP binding site [chemical binding]; other site 550538019190 Walker B motif; other site 550538019191 arginine finger; other site 550538019192 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 2.7e-65 550538019193 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538019194 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019195 HMMPfam hit to PF06956, Regulator of RNA terminal phosphate cyclase, score 2.7e-132 550538019196 TROVE domain; Region: TROVE; pfam05731 550538019197 HMMPfam hit to PF05731, TROVE, score 1.2e-116 550538019198 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 550538019199 hypothetical protein; Reviewed; Region: PRK09588 550538019200 HMMPfam hit to PF01139, Protein of unknown function UPF0027, score 1.7e-197 550538019201 PS01288 Uncharacterized protein family UPF0027 signature. 550538019202 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 550538019203 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 550538019204 putative active site [active] 550538019205 adenylation catalytic residue [active] 550538019206 HMMPfam hit to PF01137, RNA 3'-terminal phosphate cyclase, score 6e-131 550538019207 HMMPfam hit to PF05189, RNA 3'-terminal phosphate cyclase, insert region, score 4.5e-08 550538019208 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 550538019209 HMMPfam hit to PF04221, RelB antitoxin, score 3.8e-35 550538019210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 550538019211 HMMPfam hit to PF05016, Plasmid stabilization system, score 1.4e-09 550538019212 transcriptional regulator MalT; Provisional; Region: PRK04841 550538019213 AAA ATPase domain; Region: AAA_16; pfam13191 550538019214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538019215 DNA binding residues [nucleotide binding] 550538019216 dimerization interface [polypeptide binding]; other site 550538019217 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.4e-24 550538019218 PS00622 Bacterial regulatory proteins, luxR family signature. 550538019219 maltodextrin phosphorylase; Provisional; Region: PRK14985 550538019220 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 550538019221 homodimer interface [polypeptide binding]; other site 550538019222 active site pocket [active] 550538019223 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 0 550538019224 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 550538019225 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 550538019226 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 550538019227 HMMPfam hit to PF02446, Glycoside hydrolase, family 77, score 5e-259 550538019228 high-affinity gluconate transporter; Provisional; Region: PRK14984 550538019229 gluconate transporter; Region: gntP; TIGR00791 550538019230 HMMPfam hit to PF02447, Gluconate transporter, score 4.9e-272 550538019231 10 probable transmembrane helices predicted for SG3926 by TMHMM2.0 at aa 7-27, 37-59, 80-98, 103-125, 159-181, 242-264, 277-296, 333-355, 362-384 and 399-421 550538019232 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 550538019233 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 550538019234 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 550538019235 HMMPfam hit to PF01106, NIF system FeS cluster assembly, NifU, C-terminal, score 9.2e-07 550538019236 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 4.8e-35 550538019237 DNA utilization protein GntX; Provisional; Region: PRK11595 550538019238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 550538019239 active site 550538019240 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 7.5e-07 550538019241 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 550538019242 carboxylesterase BioH; Provisional; Region: PRK10349 550538019243 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 550538019244 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 4.6e-33 550538019245 hypothetical protein; Provisional; Region: PRK09956 550538019246 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 550538019247 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 8e-210 550538019248 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 550538019249 HMMPfam hit to PF09012, Protein of unknown function DUF1920, score 2e-56 550538019250 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 550538019251 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 550538019252 G1 box; other site 550538019253 GTP/Mg2+ binding site [chemical binding]; other site 550538019254 Switch I region; other site 550538019255 G2 box; other site 550538019256 G3 box; other site 550538019257 Switch II region; other site 550538019258 G4 box; other site 550538019259 G5 box; other site 550538019260 Nucleoside recognition; Region: Gate; pfam07670 550538019261 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 550538019262 Nucleoside recognition; Region: Gate; pfam07670 550538019263 10 probable transmembrane helices predicted for SG3932 by TMHMM2.0 at aa 277-299, 309-331, 344-366, 386-408, 429-447, 451-473, 510-532, 663-685, 692-714 and 720-742 550538019264 HMMPfam hit to PF07670, Nucleoside recognition, score 3.1e-18 550538019265 HMMPfam hit to PF07664, Ferrous iron transport B, C-terminal, score 4.7e-23 550538019266 HMMPfam hit to PF07670, Nucleoside recognition, score 3.1e-16 550538019267 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019268 HMMPfam hit to PF02421, Ferrous iron transport protein B, N-terminal, score 3.9e-44 550538019269 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.9e-38 550538019270 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019271 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 550538019272 HMMPfam hit to PF04023, Ferrous iron transporter, FeoA subunit, score 2.1e-08 550538019273 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 550538019274 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 550538019275 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 550538019276 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 550538019277 RNA binding site [nucleotide binding]; other site 550538019278 HMMPfam hit to PF00575, S1, RNA binding, score 2e-28 550538019279 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 550538019280 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 550538019281 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 550538019282 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 2.4e-42 550538019283 PS00830 Prokaryotic transcription elongation factors signature 2. 550538019284 HMMPfam hit to PF03449, Transcription elongation factor, GreA/GreB region, prokaryotic, score 1e-43 550538019285 PS00829 Prokaryotic transcription elongation factors signature 1. 550538019286 osmolarity response regulator; Provisional; Region: ompR; PRK09468 550538019287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538019288 active site 550538019289 phosphorylation site [posttranslational modification] 550538019290 intermolecular recognition site; other site 550538019291 dimerization interface [polypeptide binding]; other site 550538019292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538019293 DNA binding site [nucleotide binding] 550538019294 HMMPfam hit to PF00072, Response regulator receiver, score 5.9e-44 550538019295 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.3e-20 550538019296 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 550538019297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538019298 dimerization interface [polypeptide binding]; other site 550538019299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538019300 dimer interface [polypeptide binding]; other site 550538019301 phosphorylation site [posttranslational modification] 550538019302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538019303 ATP binding site [chemical binding]; other site 550538019304 G-X-G motif; other site 550538019305 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 7.9e-11 550538019306 1 probable transmembrane helix predicted for SG3937 by TMHMM2.0 at aa 121-140 550538019307 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 8.3e-14 550538019308 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.3e-34 550538019309 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 550538019310 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 550538019311 active site 550538019312 substrate-binding site [chemical binding]; other site 550538019313 metal-binding site [ion binding] 550538019314 ATP binding site [chemical binding]; other site 550538019315 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, ATP-utilising, score 0 550538019316 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 550538019317 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019318 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 550538019319 11 probable transmembrane helices predicted for SG3939 by TMHMM2.0 at aa 12-34, 39-61, 66-84, 99-118, 138-160, 183-200, 213-235, 250-268, 281-303, 318-340 and 353-375 550538019320 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 550538019321 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 550538019322 dimerization interface [polypeptide binding]; other site 550538019323 domain crossover interface; other site 550538019324 redox-dependent activation switch; other site 550538019325 HMMPfam hit to PF01430, Hsp33 protein, score 7.9e-145 550538019326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538019327 RNA binding surface [nucleotide binding]; other site 550538019328 HMMPfam hit to PF01479, RNA-binding S4, score 1.6e-12 550538019329 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 550538019330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538019331 motif II; other site 550538019332 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 7.8e-24 550538019333 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 550538019334 HMMPfam hit to PF07095, Intracellular growth attenuator IgaA, score 0 550538019335 5 probable transmembrane helices predicted for SG3943 by TMHMM2.0 at aa 4-22, 202-221, 225-247, 336-358 and 652-674 550538019336 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538019337 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 550538019338 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 550538019339 ADP-ribose binding site [chemical binding]; other site 550538019340 dimer interface [polypeptide binding]; other site 550538019341 active site 550538019342 nudix motif; other site 550538019343 metal binding site [ion binding]; metal-binding site 550538019344 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.2e-15 550538019345 PS00893 mutT domain signature. 550538019346 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 550538019347 Transglycosylase; Region: Transgly; pfam00912 550538019348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 550538019349 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 2.8e-25 550538019350 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 8.7e-94 550538019351 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019352 1 probable transmembrane helix predicted for SG3945 by TMHMM2.0 at aa 12-34 550538019353 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 550538019354 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 550538019355 HMMPfam hit to PF05137, Fimbrial assembly, score 4.5e-15 550538019356 1 probable transmembrane helix predicted for SG3947 by TMHMM2.0 at aa 21-43 550538019357 1 probable transmembrane helix predicted for SG3948 by TMHMM2.0 at aa 15-37 550538019358 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 550538019359 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 550538019360 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 550538019361 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 550538019362 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019363 HMMPfam hit to PF07660, Secretin/TonB, short N-terminal, score 3.8e-07 550538019364 HMMPfam hit to PF03958, NolW-like, score 1.1e-11 550538019365 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 1.4e-84 550538019366 PS00875 Bacterial type II secretion system protein D signature. 550538019367 shikimate kinase; Reviewed; Region: aroK; PRK00131 550538019368 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 550538019369 ADP binding site [chemical binding]; other site 550538019370 magnesium binding site [ion binding]; other site 550538019371 putative shikimate binding site; other site 550538019372 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019373 HMMPfam hit to PF01202, Shikimate kinase, score 2.4e-81 550538019374 PS01128 Shikimate kinase signature. 550538019375 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 550538019376 active site 550538019377 dimer interface [polypeptide binding]; other site 550538019378 metal binding site [ion binding]; metal-binding site 550538019379 HMMPfam hit to PF01761, 3-dehydroquinate synthase AroB, score 1.8e-180 550538019380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 550538019381 cell division protein DamX; Validated; Region: PRK10905 550538019382 1 probable transmembrane helix predicted for SG3953 by TMHMM2.0 at aa 93-115 550538019383 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 9e-17 550538019384 DNA adenine methylase; Provisional; Region: PRK10904 550538019385 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA methyltransferase, score 3.2e-100 550538019386 PS00092 N-6 Adenine-specific DNA methylases signature. 550538019387 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 550538019388 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 550538019389 substrate binding site [chemical binding]; other site 550538019390 hexamer interface [polypeptide binding]; other site 550538019391 metal binding site [ion binding]; metal-binding site 550538019392 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 7e-143 550538019393 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 550538019394 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 550538019395 phosphoglycolate phosphatase; Provisional; Region: PRK13222 550538019396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538019397 motif II; other site 550538019398 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.7e-44 550538019399 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 550538019400 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 550538019401 active site 550538019402 HIGH motif; other site 550538019403 dimer interface [polypeptide binding]; other site 550538019404 KMSKS motif; other site 550538019405 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 6.7e-132 550538019406 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538019407 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 550538019408 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538019410 HMMPfam hit to PF03797, Autotransporter beta-domain, score 7.4e-36 550538019411 siroheme synthase; Provisional; Region: cysG; PRK10637 550538019412 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 550538019413 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 550538019414 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 550538019415 active site 550538019416 SAM binding site [chemical binding]; other site 550538019417 homodimer interface [polypeptide binding]; other site 550538019418 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 1.2e-99 550538019419 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 550538019420 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 550538019421 nitrite transporter NirC; Provisional; Region: PRK11562 550538019422 HMMPfam hit to PF01226, Formate/nitrite transporter, score 8.1e-139 550538019423 6 probable transmembrane helices predicted for SG3963 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 150-172, 184-206 and 226-248 550538019424 PS01006 Formate and nitrite transporters signature 2. 550538019425 PS01005 Formate and nitrite transporters signature 1. 550538019426 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 550538019427 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538019428 nitrite reductase subunit NirD; Provisional; Region: PRK14989 550538019429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 550538019430 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 550538019431 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 550538019432 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 550538019433 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S region, score 1.4e-47 550538019434 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 550538019435 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 1.3e-19 550538019436 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 1.5e-24 550538019437 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 3.3e-51 550538019438 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 9.5e-30 550538019439 putative transporter; Provisional; Region: PRK03699 550538019440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538019441 putative substrate translocation pore; other site 550538019442 12 probable transmembrane helices predicted for SG3966 by TMHMM2.0 at aa 12-34, 49-66, 78-95, 99-121, 134-156, 161-183, 204-226, 246-268, 273-292, 297-319, 332-354 and 359-381 550538019443 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 6.8e-19 550538019444 PS00217 Sugar transport proteins signature 2. 550538019445 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 550538019446 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 550538019447 substrate binding site [chemical binding]; other site 550538019448 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 6.2e-75 550538019449 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 550538019450 hypothetical protein; Provisional; Region: PRK10204 550538019451 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 550538019452 cell filamentation protein Fic; Provisional; Region: PRK10347 550538019453 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 9.5e-35 550538019454 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 550538019455 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 550538019456 glutamine binding [chemical binding]; other site 550538019457 catalytic triad [active] 550538019458 PS00678 Trp-Asp (WD) repeats signature. 550538019459 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 6.5e-88 550538019460 PS00442 Glutamine amidotransferases class-I active site. 550538019461 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019462 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 550538019463 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 550538019464 inhibitor-cofactor binding pocket; inhibition site 550538019465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538019466 catalytic residue [active] 550538019467 HMMPfam hit to PF00202, Aminotransferase class-III, score 8.3e-185 550538019468 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 550538019469 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 550538019470 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 550538019471 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 550538019472 HMMPfam hit to PF05976, Protein of unknown function DUF893, YccS/YhfK, score 9.3e-09 550538019473 8 probable transmembrane helices predicted for SG3972 by TMHMM2.0 at aa 21-43, 78-100, 107-129, 134-156, 411-433, 437-453, 458-477 and 487-506 550538019474 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 550538019475 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 550538019476 ligand binding site [chemical binding]; other site 550538019477 flexible hinge region; other site 550538019478 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 550538019479 putative switch regulator; other site 550538019480 non-specific DNA interactions [nucleotide binding]; other site 550538019481 DNA binding site [nucleotide binding] 550538019482 sequence specific DNA binding site [nucleotide binding]; other site 550538019483 putative cAMP binding site [chemical binding]; other site 550538019484 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 5.9e-17 550538019485 PS00042 Bacterial regulatory proteins, crp family signature. 550538019486 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 5.7e-29 550538019487 PS00889 Cyclic nucleotide-binding domain signature 2. 550538019488 PS00888 Cyclic nucleotide-binding domain signature 1. 550538019489 hypothetical protein; Provisional; Region: PRK10738 550538019490 HMMPfam hit to PF02566, OsmC-like protein, score 1.8e-27 550538019491 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 550538019492 active site 550538019493 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 9.9e-121 550538019494 PS00567 Phosphoribulokinase signature. 550538019495 hypothetical protein; Provisional; Region: PRK04966 550538019496 HMMPfam hit to PF06794, Protein of unknown function UPF0270, score 4e-48 550538019497 putative hydrolase; Provisional; Region: PRK10985 550538019498 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 5.7e-25 550538019499 PS01133 Uncharacterized protein family UPF0017 signature. 550538019500 putative monooxygenase; Provisional; Region: PRK11118 550538019501 HMMPfam hit to PF08803, Mono-oxygenase, YdhR, score 2.3e-71 550538019502 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 550538019503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538019504 Walker A/P-loop; other site 550538019505 ATP binding site [chemical binding]; other site 550538019506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538019507 ABC transporter signature motif; other site 550538019508 Walker B; other site 550538019509 D-loop; other site 550538019510 ABC transporter; Region: ABC_tran_2; pfam12848 550538019511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538019512 HMMPfam hit to PF00005, ABC transporter related, score 5.6e-44 550538019513 PS00211 ABC transporters family signature. 550538019514 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019515 HMMPfam hit to PF00005, ABC transporter related, score 8e-48 550538019516 PS00211 ABC transporters family signature. 550538019517 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019518 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 550538019519 HMMPfam hit to PF02525, Flavodoxin-like fold, score 7.5e-68 550538019521 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 1.3e-75 550538019522 HMMPfam hit to PF02254, TrkA-N, score 1.2e-29 550538019523 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 550538019524 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 550538019525 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 550538019526 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 0.00018 550538019527 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 550538019528 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 550538019529 phi X174 lysis protein; Provisional; Region: PRK02793 550538019530 HMMPfam hit to PF04102, SlyX, score 1.7e-37 550538019531 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 550538019532 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 550538019533 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 550538019534 HMMPfam hit to PF01346, Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal, score 2e-60 550538019535 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 2.9e-46 550538019536 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 550538019537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 550538019538 YheO-like PAS domain; Region: PAS_6; pfam08348 550538019539 HTH domain; Region: HTH_22; pfam13309 550538019540 HMMPfam hit to PF08348, YheO-like, score 2.7e-59 550538019541 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 550538019542 HMMPfam hit to PF02635, DsrE-like protein, score 2.3e-55 550538019543 sulfur relay protein TusC; Validated; Region: PRK00211 550538019544 HMMPfam hit to PF02635, DsrE-like protein, score 1.9e-41 550538019545 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 550538019546 HMMPfam hit to PF04077, DsrH like protein, score 1.6e-30 550538019547 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 550538019548 S17 interaction site [polypeptide binding]; other site 550538019549 S8 interaction site; other site 550538019550 16S rRNA interaction site [nucleotide binding]; other site 550538019551 streptomycin interaction site [chemical binding]; other site 550538019552 23S rRNA interaction site [nucleotide binding]; other site 550538019553 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 550538019554 HMMPfam hit to PF00164, Ribosomal protein S12/S23, score 3.4e-75 550538019555 PS00055 Ribosomal protein S12 signature. 550538019556 30S ribosomal protein S7; Validated; Region: PRK05302 550538019557 HMMPfam hit to PF00177, Ribosomal protein S7, score 1.1e-88 550538019558 PS00052 Ribosomal protein S7 signature. 550538019559 elongation factor G; Reviewed; Region: PRK00007 550538019560 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 550538019561 G1 box; other site 550538019562 putative GEF interaction site [polypeptide binding]; other site 550538019563 GTP/Mg2+ binding site [chemical binding]; other site 550538019564 Switch I region; other site 550538019565 G2 box; other site 550538019566 G3 box; other site 550538019567 Switch II region; other site 550538019568 G4 box; other site 550538019569 G5 box; other site 550538019570 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 550538019571 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 550538019572 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 550538019573 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4e-113 550538019574 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019575 PS00301 GTP-binding elongation factors signature. 550538019576 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 4.9e-20 550538019577 HMMPfam hit to PF03764, Translation elongation factor EFG/EF2, domain IV, score 1.6e-67 550538019578 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 3.7e-47 550538019579 elongation factor Tu; Reviewed; Region: PRK00049 550538019580 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 550538019581 G1 box; other site 550538019582 GEF interaction site [polypeptide binding]; other site 550538019583 GTP/Mg2+ binding site [chemical binding]; other site 550538019584 Switch I region; other site 550538019585 G2 box; other site 550538019586 G3 box; other site 550538019587 Switch II region; other site 550538019588 G4 box; other site 550538019589 G5 box; other site 550538019590 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 550538019591 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 550538019592 Antibiotic Binding Site [chemical binding]; other site 550538019593 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 3.3e-96 550538019594 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019595 PS00301 GTP-binding elongation factors signature. 550538019596 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.3e-26 550538019597 HMMPfam hit to PF03143, Translation elongation factor EFTu/EF1A, C-terminal, score 1e-60 550538019598 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 550538019599 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 1.9e-19 550538019600 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 550538019601 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 550538019602 heme binding site [chemical binding]; other site 550538019603 ferroxidase pore; other site 550538019604 ferroxidase diiron center [ion binding]; other site 550538019605 HMMPfam hit to PF00210, Ferritin and Dps, score 2.2e-50 550538019606 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 550538019607 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 550538019608 4 probable transmembrane helices predicted for SG3997 by TMHMM2.0 at aa 4-21, 55-74, 101-123 and 130-152 550538019609 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019610 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 1.2e-24 550538019611 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 550538019612 HMMPfam hit to PF00338, Ribosomal protein S10, score 5.8e-62 550538019613 PS00361 Ribosomal protein S10 signature. 550538019614 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 550538019615 HMMPfam hit to PF00297, Ribosomal protein L3, score 4.8e-108 550538019616 PS00474 Ribosomal protein L3 signature. 550538019617 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 550538019618 HMMPfam hit to PF00573, Ribosomal protein L4/L1e, score 1.6e-55 550538019619 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 550538019620 PS00430 TonB-dependent receptor proteins signature 1. 550538019621 HMMPfam hit to PF00276, Ribosomal protein L25/L23, score 2.3e-44 550538019622 PS00050 Ribosomal protein L23 signature. 550538019623 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 550538019624 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 550538019625 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 550538019626 HMMPfam hit to PF00181, Ribosomal protein L2, score 1.8e-47 550538019627 HMMPfam hit to PF03947, Ribosomal protein L2, score 3.3e-82 550538019628 PS00467 Ribosomal protein L2 signature. 550538019629 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 550538019630 HMMPfam hit to PF00203, Ribosomal protein S19/S15, score 1.3e-53 550538019631 PS00323 Ribosomal protein S19 signature. 550538019632 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 550538019633 protein-rRNA interface [nucleotide binding]; other site 550538019634 putative translocon binding site; other site 550538019635 HMMPfam hit to PF00237, Ribosomal protein L22/L17, score 3.2e-60 550538019636 PS00464 Ribosomal protein L22 signature. 550538019637 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 550538019638 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 550538019639 G-X-X-G motif; other site 550538019640 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 550538019641 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal, score 5.8e-29 550538019642 HMMPfam hit to PF07650, K Homology, type 2, score 1.9e-19 550538019643 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal, score 7.4e-54 550538019644 PS00548 Ribosomal protein S3 signature. 550538019645 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 550538019646 23S rRNA interface [nucleotide binding]; other site 550538019647 5S rRNA interface [nucleotide binding]; other site 550538019648 putative antibiotic binding site [chemical binding]; other site 550538019649 L25 interface [polypeptide binding]; other site 550538019650 L27 interface [polypeptide binding]; other site 550538019651 HMMPfam hit to PF00252, Ribosomal protein L16, score 1.6e-92 550538019652 PS00586 Ribosomal protein L16 signature 1. 550538019653 PS00701 Ribosomal protein L16 signature 2. 550538019654 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 550538019655 23S rRNA interface [nucleotide binding]; other site 550538019656 putative translocon interaction site; other site 550538019657 signal recognition particle (SRP54) interaction site; other site 550538019658 L23 interface [polypeptide binding]; other site 550538019659 trigger factor interaction site; other site 550538019660 HMMPfam hit to PF00831, Ribosomal protein L29, score 2.6e-28 550538019661 PS00579 Ribosomal protein L29 signature. 550538019662 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 550538019663 HMMPfam hit to PF00366, Ribosomal protein S17, score 1.5e-42 550538019664 PS00056 Ribosomal protein S17 signature. 550538019665 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 550538019666 HMMPfam hit to PF00238, Ribosomal protein L14b/L23e, score 5.3e-81 550538019667 PS00049 Ribosomal protein L14 signature. 550538019668 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 550538019669 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 550538019670 RNA binding site [nucleotide binding]; other site 550538019671 HMMPfam hit to PF00467, KOW, score 6.9e-07 550538019672 PS01108 Ribosomal protein L24 signature. 550538019673 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 550538019674 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 550538019675 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 550538019676 HMMPfam hit to PF00281, Ribosomal protein L5, score 6.6e-33 550538019677 PS00358 Ribosomal protein L5 signature. 550538019678 HMMPfam hit to PF00673, Ribosomal protein L5, score 1.6e-58 550538019679 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 550538019680 HMMPfam hit to PF00253, Ribosomal protein S14, score 9e-25 550538019681 PS00527 Ribosomal protein S14 signature. 550538019682 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 550538019683 HMMPfam hit to PF00410, Ribosomal protein S8, score 7.2e-72 550538019684 PS00053 Ribosomal protein S8 signature. 550538019685 PS00294 Prenyl group binding site (CAAX box). 550538019686 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 550538019687 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 550538019688 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 550538019689 HMMPfam hit to PF00347, Ribosomal protein L6, score 3.7e-21 550538019690 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.9e-30 550538019691 PS00525 Ribosomal protein L6 signature 1. 550538019692 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 550538019693 23S rRNA interface [nucleotide binding]; other site 550538019694 5S rRNA interface [nucleotide binding]; other site 550538019695 L27 interface [polypeptide binding]; other site 550538019696 L5 interface [polypeptide binding]; other site 550538019697 HMMPfam hit to PF00861, Ribosomal protein L18/L5, score 2.1e-52 550538019698 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 550538019699 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 550538019700 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 550538019701 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal, score 4.8e-41 550538019702 PS00585 Ribosomal protein S5 signature. 550538019703 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal, score 5.8e-43 550538019704 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 550538019705 23S rRNA binding site [nucleotide binding]; other site 550538019706 HMMPfam hit to PF00327, Ribosomal protein L30, score 1.1e-23 550538019707 PS00634 Ribosomal protein L30 signature. 550538019708 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 550538019709 HMMPfam hit to PF01305, Ribosomal protein L15, score 1.3e-56 550538019710 HMMPfam hit to PF00256, Ribosomal protein L15, score 2.5e-10 550538019711 PS00475 Ribosomal protein L15 signature. 550538019712 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 550538019713 SecY translocase; Region: SecY; pfam00344 550538019714 10 probable transmembrane helices predicted for SG4019 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 373-392 and 397-414 550538019715 HMMPfam hit to PF00344, SecY protein, score 7.2e-212 550538019716 PS00755 Protein secY signature 1. 550538019717 PS00756 Protein secY signature 2. 550538019718 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 550538019719 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 550538019720 HMMPfam hit to PF00444, Ribosomal protein L36, score 6e-16 550538019721 PS00828 Ribosomal protein L36 signature. 550538019722 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 550538019723 30S ribosomal protein S13; Region: bact_S13; TIGR03631 550538019724 HMMPfam hit to PF00416, Ribosomal protein S13, score 1.8e-63 550538019725 PS00061 Short-chain dehydrogenases/reductases family signature. 550538019726 PS00646 Ribosomal protein S13 signature. 550538019727 30S ribosomal protein S11; Validated; Region: PRK05309 550538019728 HMMPfam hit to PF00411, Ribosomal protein S11, score 4.5e-76 550538019729 PS00054 Ribosomal protein S11 signature. 550538019730 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 550538019731 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 550538019732 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538019733 RNA binding surface [nucleotide binding]; other site 550538019734 HMMPfam hit to PF00163, Ribosomal protein S4, score 1.1e-37 550538019735 PS00632 Ribosomal protein S4 signature. 550538019736 HMMPfam hit to PF01479, RNA-binding S4, score 2e-21 550538019737 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 550538019738 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 550538019739 alphaNTD homodimer interface [polypeptide binding]; other site 550538019740 alphaNTD - beta interaction site [polypeptide binding]; other site 550538019741 alphaNTD - beta' interaction site [polypeptide binding]; other site 550538019742 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 550538019743 HMMPfam hit to PF01193, RNA polymerase, dimerisation, score 8.2e-24 550538019744 HMMPfam hit to PF01000, RNA polymerase, insert, score 2.1e-58 550538019745 HMMPfam hit to PF03118, RNA polymerase, alpha subunit, C-terminal, score 1.9e-35 550538019746 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 550538019747 HMMPfam hit to PF01196, Ribosomal protein L17, score 6.2e-67 550538019748 PS01167 Ribosomal protein L17 signature. 550538019749 hypothetical protein; Provisional; Region: PRK10203 550538019750 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 550538019751 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 550538019752 DNA binding residues [nucleotide binding] 550538019753 dimer interface [polypeptide binding]; other site 550538019754 metal binding site [ion binding]; metal-binding site 550538019755 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 6.1e-10 550538019756 PS00552 Bacterial regulatory proteins, merR family signature. 550538019757 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 6.9e-25 550538019758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 550538019759 HMMPfam hit to PF03889, Protein of unknown function DUF331, score 3.7e-30 550538019760 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 550538019761 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 550538019762 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel, score 9.5e-88 550538019763 2 probable transmembrane helices predicted for SG4028 by TMHMM2.0 at aa 20-42 and 77-99 550538019764 PS01327 Large-conductance mechanosensitive channels mscL family signature. 550538019765 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 550538019766 TrkA-N domain; Region: TrkA_N; pfam02254 550538019767 TrkA-C domain; Region: TrkA_C; pfam02080 550538019768 TrkA-N domain; Region: TrkA_N; pfam02254 550538019769 TrkA-C domain; Region: TrkA_C; pfam02080 550538019770 HMMPfam hit to PF02080, TrkA-C, score 2.5e-11 550538019771 HMMPfam hit to PF02254, TrkA-N, score 2.3e-35 550538019772 HMMPfam hit to PF02080, TrkA-C, score 1.6e-11 550538019773 HMMPfam hit to PF02254, TrkA-N, score 5.9e-36 550538019774 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 550538019775 putative RNA binding site [nucleotide binding]; other site 550538019776 16S rRNA methyltransferase B; Provisional; Region: PRK10901 550538019777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538019778 S-adenosylmethionine binding site [chemical binding]; other site 550538019779 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 5.4e-139 550538019780 PS01153 NOL1/NOP2/sun family signature. 550538019781 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 7.3e-43 550538019782 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 550538019783 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 550538019784 putative active site [active] 550538019785 substrate binding site [chemical binding]; other site 550538019786 putative cosubstrate binding site; other site 550538019787 catalytic site [active] 550538019788 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 550538019789 substrate binding site [chemical binding]; other site 550538019790 HMMPfam hit to PF02911, Formyl transferase, C-terminal, score 4.7e-47 550538019791 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 5.7e-83 550538019792 PS00373 Phosphoribosylglycinamide formyltransferase active site. 550538019793 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 550538019794 active site 550538019795 catalytic residues [active] 550538019796 metal binding site [ion binding]; metal-binding site 550538019797 HMMPfam hit to PF01327, Formylmethionine deformylase, score 4.4e-89 550538019799 HMMPfam hit to PF02481, SMF protein, score 1.2e-109 550538019800 hypothetical protein; Validated; Region: PRK03430 550538019801 HMMPfam hit to PF04361, Protein of unknown function DUF494, score 3.2e-119 550538019802 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 550538019803 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 550538019804 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 550538019805 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 550538019806 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 4.5e-17 550538019807 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 5.1e-16 550538019808 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 4.7e-14 550538019809 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 550538019810 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 4.4e-46 550538019811 PS01147 SUA5/yciO/yrdC family signature. 550538019812 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 550538019813 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 550538019814 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 550538019815 shikimate binding site; other site 550538019816 NAD(P) binding site [chemical binding]; other site 550538019817 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate binding, N-terminal, score 1e-26 550538019818 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 1.8e-30 550538019819 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 550538019820 HMMPfam hit to PF07369, Protein of unknown function DUF1488, score 7.3e-55 550538019821 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 550538019822 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 550538019823 trimer interface [polypeptide binding]; other site 550538019824 putative metal binding site [ion binding]; other site 550538019825 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 7.8 550538019826 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.71 550538019827 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 24 550538019828 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1e+02 550538019829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 550538019830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538019831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 550538019832 Coenzyme A binding pocket [chemical binding]; other site 550538019833 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 5.1e-19 550538019834 homoserine O-succinyltransferase; Provisional; Region: PRK05368 550538019835 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 550538019836 proposed active site lysine [active] 550538019837 conserved cys residue [active] 550538019838 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 1.2e-204 550538019839 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 550538019840 malate synthase A; Region: malate_syn_A; TIGR01344 550538019841 active site 550538019842 HMMPfam hit to PF01274, Malate synthase, score 0 550538019843 PS00510 Malate synthase signature. 550538019844 isocitrate lyase; Provisional; Region: PRK15063 550538019845 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 550538019846 tetramer interface [polypeptide binding]; other site 550538019847 active site 550538019848 Mg2+/Mn2+ binding site [ion binding]; other site 550538019849 HMMPfam hit to PF00463, Isocitrate lyase and phosphorylmutase, score 1.3e-288 550538019850 PS00161 Isocitrate lyase signature. 550538019851 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 550538019852 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 550538019853 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 550538019854 HMMPfam hit to PF06315, Isocitrate dehydrogenase kinasephosphatase, score 0 550538019855 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 550538019856 HMMPfam hit to PF06171, Protein of unknown function DUF984, score 9.9e-71 550538019857 transcriptional repressor IclR; Provisional; Region: PRK11569 550538019858 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 550538019859 Bacterial transcriptional regulator; Region: IclR; pfam01614 550538019860 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 7.6e-54 550538019861 PS01051 Bacterial regulatory proteins, iclR family signature. 550538019862 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 6.1e-33 550538019863 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 550538019864 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 550538019865 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 550538019866 substrate binding pocket [chemical binding]; other site 550538019867 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 550538019868 B12 binding site [chemical binding]; other site 550538019869 cobalt ligand [ion binding]; other site 550538019870 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 550538019871 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 4.5e-167 550538019872 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 1.5e-80 550538019873 HMMPfam hit to PF02607, Methionine synthase, cobalamin (vitamin B12)-binding module, cap, score 9.1e-46 550538019874 HMMPfam hit to PF02310, Cobalamin (vitamin B12)-binding, score 2.4e-28 550538019875 HMMPfam hit to PF02965, Vitamin B12 dependent methionine synthase, activation region, score 1.8e-80 550538019876 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 550538019877 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 550538019878 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 1e-51 550538019879 7 probable transmembrane helices predicted for SG4049 by TMHMM2.0 at aa 42-64, 74-96, 108-130, 150-172, 177-199, 214-236 and 249-271 550538019880 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 550538019881 active site pocket [active] 550538019882 oxyanion hole [active] 550538019883 catalytic triad [active] 550538019884 active site nucleophile [active] 550538019885 HMMPfam hit to PF03575, Peptidase S51, dipeptidase E, score 7.7e-79 550538019886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 550538019887 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 550538019888 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 550538019889 RNA binding surface [nucleotide binding]; other site 550538019890 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 550538019891 probable active site [active] 550538019892 HMMPfam hit to PF01479, RNA-binding S4, score 8.5e-13 550538019893 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.9e-27 550538019894 PS01149 Rsu family of pseudouridine synthase signature. 550538019895 hypothetical protein; Provisional; Region: PRK10515 550538019896 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 550538019897 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 550538019898 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538019899 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.3e-34 550538019900 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2.3e-17 550538019901 PS00894 Bacterial regulatory proteins, deoR family signature. 550538019902 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 550538019903 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 550538019904 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 6.9e-36 550538019905 PS01229 Hypothetical cof family signature 2. 550538019906 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 550538019907 active site 550538019908 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 550538019909 phosphate binding site [ion binding]; other site 550538019910 the sequence has been checked and is believed to be correct 550538019911 similar to SEN3984 accession AM933172 550538019912 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.1 550538019913 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 8.4 550538019914 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 30 550538019915 Mor transcription activator family; Region: Mor; pfam08765 550538019916 HMMPfam hit to PF08765, Mor transcription activator, score 7.7e-56 550538019917 aspartate kinase III; Validated; Region: PRK09084 550538019918 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 550538019919 nucleotide binding site [chemical binding]; other site 550538019920 substrate binding site [chemical binding]; other site 550538019921 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 550538019922 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 550538019923 dimer interface [polypeptide binding]; other site 550538019924 HMMPfam hit to PF01842, Amino acid-binding ACT, score 7.5e-06 550538019925 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 2.3e-62 550538019926 PS00324 Aspartokinase signature. 550538019927 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 550538019928 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 550538019929 active site 550538019930 dimer interface [polypeptide binding]; other site 550538019931 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 550538019932 dimer interface [polypeptide binding]; other site 550538019933 active site 550538019934 HMMPfam hit to PF00342, Phosphoglucose isomerase (PGI), score 0 550538019935 PS00765 Phosphoglucose isomerase signature 1. 550538019936 PS00174 Phosphoglucose isomerase signature 2. 550538019937 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 550538019938 1 probable transmembrane helix predicted for SG4064 by TMHMM2.0 at aa 5-27 550538019939 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 550538019940 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538019941 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 550538019942 HMMPfam hit to PF06251, Protein of unknown function DUF1017, score 6.8e-151 550538019943 1 probable transmembrane helix predicted for SG4066 by TMHMM2.0 at aa 5-27 550538019944 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 550538019945 HMMPfam hit to PF06082, Protein of unknown function DUF940, bacterial membrane lipoprotein , score 0 550538019946 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538019947 Predicted membrane protein [Function unknown]; Region: COG3223 550538019948 HMMPfam hit to PF06146, Phosphate-starvation-inducible E, score 7.5e-75 550538019949 4 probable transmembrane helices predicted for SG4068 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 113-130 550538019950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 550538019951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538019952 dimer interface [polypeptide binding]; other site 550538019953 conserved gate region; other site 550538019954 putative PBP binding loops; other site 550538019955 ABC-ATPase subunit interface; other site 550538019956 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-17 550538019957 6 probable transmembrane helices predicted for SG4069 by TMHMM2.0 at aa 13-35, 89-111, 124-143, 153-175, 205-227 and 258-280 550538019958 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538019959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 550538019960 dimer interface [polypeptide binding]; other site 550538019961 conserved gate region; other site 550538019962 putative PBP binding loops; other site 550538019963 ABC-ATPase subunit interface; other site 550538019964 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5e-11 550538019965 8 probable transmembrane helices predicted for SG4070 by TMHMM2.0 at aa 17-36, 40-57, 70-92, 284-306, 319-341, 370-392, 413-435 and 484-506 550538019966 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538019967 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 550538019968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 550538019969 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.1e-40 550538019970 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 550538019971 1 probable transmembrane helix predicted for SG4072 by TMHMM2.0 at aa 7-29 550538019972 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 550538019973 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 550538019974 Walker A/P-loop; other site 550538019975 ATP binding site [chemical binding]; other site 550538019976 Q-loop/lid; other site 550538019977 ABC transporter signature motif; other site 550538019978 Walker B; other site 550538019979 D-loop; other site 550538019980 H-loop/switch region; other site 550538019981 TOBE domain; Region: TOBE_2; pfam08402 550538019982 HMMPfam hit to PF00005, ABC transporter related, score 7.1e-59 550538019983 PS00017 ATP/GTP-binding site motif A (P-loop). 550538019984 PS00211 ABC transporters family signature. 550538019985 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 1.9e-15 550538019986 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 550538019987 trimer interface; other site 550538019988 sugar binding site [chemical binding]; other site 550538019989 HMMPfam hit to PF02264, Porin, LamB type, score 5.6e-277 550538019990 maltose regulon periplasmic protein; Provisional; Region: PRK10564 550538019991 1 probable transmembrane helix predicted for SG4075 by TMHMM2.0 at aa 7-26 550538019992 HMMPfam hit to PF07148, Maltose operon periplasmic, score 4.6e-176 550538019993 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 550538019994 HMMPfam hit to PF04345, Chorismate lyase, score 1.2e-25 550538019995 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 550538019996 UbiA prenyltransferase family; Region: UbiA; pfam01040 550538019997 7 probable transmembrane helices predicted for SG4077 by TMHMM2.0 at aa 23-40, 45-67, 99-132, 160-182, 203-225, 229-251 and 272-289 550538019998 HMMPfam hit to PF01040, UbiA prenyltransferase, score 1.5e-84 550538019999 PS00943 UbiA prenyltransferase family signature. 550538020000 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 550538020001 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 550538020002 putative acyl-acceptor binding pocket; other site 550538020003 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 1.3e-44 550538020004 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 550538020005 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 6e-57 550538020006 2 probable transmembrane helices predicted for SG4079 by TMHMM2.0 at aa 57-79 and 99-121 550538020007 PS01069 Prokaryotic diacylglycerol kinase signature. 550538020008 LexA repressor; Validated; Region: PRK00215 550538020009 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 550538020010 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 550538020011 Catalytic site [active] 550538020012 HMMPfam hit to PF01726, LexA DNA-binding region, score 2.3e-47 550538020013 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 1.5e-21 550538020014 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 550538020015 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 550538020016 12 probable transmembrane helices predicted for SG4081 by TMHMM2.0 at aa 11-33, 43-65, 89-111, 131-153, 160-182, 187-209, 241-263, 267-289, 321-343, 353-375, 388-405 and 409-428 550538020017 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.9e-39 550538020018 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 0.0013 550538020019 hypothetical protein; Provisional; Region: PRK10428 550538020020 HMMPfam hit to PF05532, CsbD-like, score 1.1e-24 550538020021 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 550538020022 metal binding site 2 [ion binding]; metal-binding site 550538020023 putative DNA binding helix; other site 550538020024 metal binding site 1 [ion binding]; metal-binding site 550538020025 dimer interface [polypeptide binding]; other site 550538020026 structural Zn2+ binding site [ion binding]; other site 550538020027 HMMPfam hit to PF01475, Ferric-uptake regulator, score 2.6e-05 550538020028 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 550538020029 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 550538020030 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 550538020031 FMN binding site [chemical binding]; other site 550538020032 active site 550538020033 catalytic residues [active] 550538020034 substrate binding site [chemical binding]; other site 550538020035 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 4e-141 550538020036 PS01136 Uncharacterized protein family UPF0034 signature. 550538020037 phage shock protein G; Reviewed; Region: pspG; PRK09459 550538020038 2 probable transmembrane helices predicted for SG4087 by TMHMM2.0 at aa 5-27 and 32-49 550538020039 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 550538020040 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 550538020041 NADP binding site [chemical binding]; other site 550538020042 dimer interface [polypeptide binding]; other site 550538020043 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 2.2e-36 550538020044 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 550538020045 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 8.5e-21 550538020046 replicative DNA helicase; Provisional; Region: PRK08006 550538020047 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 550538020048 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 550538020049 Walker A motif; other site 550538020050 ATP binding site [chemical binding]; other site 550538020051 Walker B motif; other site 550538020052 DNA binding loops [nucleotide binding] 550538020053 HMMPfam hit to PF00772, DNA helicase, DnaB-like, N-terminal, score 5.8e-58 550538020054 HMMPfam hit to PF03796, DNA helicase, DnaB-like, C-terminal, score 2e-136 550538020055 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020056 alanine racemase; Reviewed; Region: alr; PRK00053 550538020057 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 550538020058 active site 550538020059 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 550538020060 substrate binding site [chemical binding]; other site 550538020061 catalytic residues [active] 550538020062 dimer interface [polypeptide binding]; other site 550538020063 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 5.1e-97 550538020064 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 550538020065 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 2e-68 550538020066 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 550538020067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 550538020068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538020069 homodimer interface [polypeptide binding]; other site 550538020070 catalytic residue [active] 550538020071 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 5.3e-128 550538020072 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 550538020073 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 550538020074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538020075 active site 550538020076 motif I; other site 550538020077 motif II; other site 550538020078 HMMPfam hit to PF03767, Acid phosphatase (Class B), score 3.1e-61 550538020079 Uncharacterized conserved protein [Function unknown]; Region: COG0432 550538020080 HMMPfam hit to PF01894, Protein of unknown function UPF0047, score 1e-53 550538020081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 550538020082 HMMPfam hit to PF04237, Protein of unknown function DUF419, score 1.4e-53 550538020083 1 probable transmembrane helix predicted for SG4096 by TMHMM2.0 at aa 7-29 550538020084 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020085 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 550538020086 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 550538020087 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 550538020088 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 550538020089 HMMPfam hit to PF00005, ABC transporter related, score 6.3e-46 550538020090 PS00211 ABC transporters family signature. 550538020091 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020092 PS00211 ABC transporters family signature. 550538020093 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020094 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 550538020095 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 550538020096 dimer interface [polypeptide binding]; other site 550538020097 ssDNA binding site [nucleotide binding]; other site 550538020098 tetramer (dimer of dimers) interface [polypeptide binding]; other site 550538020099 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 1.4e-35 550538020100 PS00735 Single-strand binding protein family signature 1. 550538020101 PS00736 Single-strand binding protein family signature 2. 550538020102 Salmonella Pathogenicity Island 4 550538020103 hypothetical protein; Validated; Region: PRK09039 550538020104 1 probable transmembrane helix predicted for SG4100 by TMHMM2.0 at aa 15-37 550538020105 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 550538020106 4 probable transmembrane helices predicted for SG4101 by TMHMM2.0 at aa 7-26, 41-63, 131-153 and 186-208 550538020107 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 550538020108 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.7e-35 550538020109 HMMPfam hit to PF02321, Outer membrane efflux protein, score 6.4e-42 550538020110 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 550538020111 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 550538020112 HlyD family secretion protein; Region: HlyD_3; pfam13437 550538020113 1 probable transmembrane helix predicted for SG4103 by TMHMM2.0 at aa 12-34 550538020114 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 0.00012 550538020115 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020116 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020118 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020119 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020120 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 550538020121 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020122 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020123 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020124 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020125 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 550538020126 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020127 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020128 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 550538020129 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020130 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020131 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020132 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020133 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 550538020134 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020135 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020136 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 550538020137 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020138 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020139 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020140 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020141 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 550538020142 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020143 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020144 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020145 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020146 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020147 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020148 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 550538020149 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020150 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 550538020151 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020152 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020153 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 550538020154 HMMPfam hit to PF07495, Two component regulator three Y, score 0.00094 550538020155 PS00307 Legume lectins beta-chain signature. 550538020156 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 5.4 550538020157 HMMPfam hit to PF07495, Two component regulator three Y, score 0.011 550538020158 HMMPfam hit to PF07495, Two component regulator three Y, score 0.014 550538020159 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 1 550538020160 HMMPfam hit to PF07495, Two component regulator three Y, score 0.0053 550538020161 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 1.1 550538020162 HMMPfam hit to PF07495, Two component regulator three Y, score 0.0006 550538020163 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 3.8 550538020164 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 1 550538020165 HMMPfam hit to PF07495, Two component regulator three Y, score 0.00076 550538020166 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 2.3 550538020167 HMMPfam hit to PF07495, Two component regulator three Y, score 0.00076 550538020168 HMMPfam hit to PF07495, Two component regulator three Y, score 0.014 550538020169 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 1 550538020170 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 1.4 550538020171 PS00213 Lipocalin signature. 550538020172 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 4.4 550538020173 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 3.9 550538020174 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 8.4 550538020175 HMMPfam hit to PF07495, Two component regulator three Y, score 0.0029 550538020176 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 52 550538020177 PS01228 Hypothetical cof family signature 1. 550538020178 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020179 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 550538020180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 550538020181 Walker A/P-loop; other site 550538020182 ATP binding site [chemical binding]; other site 550538020183 Q-loop/lid; other site 550538020184 ABC transporter signature motif; other site 550538020185 Walker B; other site 550538020186 D-loop; other site 550538020187 H-loop/switch region; other site 550538020188 5 probable transmembrane helices predicted for SG4105 by TMHMM2.0 at aa 157-179, 189-208, 262-284, 288-310 and 376-398 550538020189 PS00501 Signal peptidases I serine active site. 550538020190 HMMPfam hit to PF00005, ABC transporter related, score 2.4e-42 550538020191 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020192 2 probable transmembrane helices predicted for SG4106 by TMHMM2.0 at aa 10-29 and 36-58 550538020194 HMMPfam hit to PF00563, EAL, score 3.5e-107 550538020195 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 550538020196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538020197 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6e-13 550538020198 PS00041 Bacterial regulatory proteins, araC family signature. 550538020199 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 8.7e-11 550538020200 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 550538020201 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 550538020202 DNA binding residues [nucleotide binding] 550538020203 dimer interface [polypeptide binding]; other site 550538020204 [2Fe-2S] cluster binding site [ion binding]; other site 550538020205 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2e-12 550538020206 PS00552 Bacterial regulatory proteins, merR family signature. 550538020207 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 3.2e-17 550538020208 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 550538020209 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 550538020210 putative C-terminal domain interface [polypeptide binding]; other site 550538020211 putative GSH binding site (G-site) [chemical binding]; other site 550538020212 putative dimer interface [polypeptide binding]; other site 550538020213 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 550538020214 putative N-terminal domain interface [polypeptide binding]; other site 550538020215 putative dimer interface [polypeptide binding]; other site 550538020216 putative substrate binding pocket (H-site) [chemical binding]; other site 550538020217 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 8.7e-14 550538020218 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 4e-06 550538020219 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 550538020220 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 5.2e-112 550538020221 12 probable transmembrane helices predicted for SG4112 by TMHMM2.0 at aa 29-51, 56-78, 85-107, 112-134, 146-165, 175-197, 202-224, 244-266, 329-351, 356-378, 391-413 and 428-447 550538020222 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020223 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 550538020224 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 550538020225 9 probable transmembrane helices predicted for SG4113 by TMHMM2.0 at aa 4-26, 86-108, 113-135, 181-203, 233-255, 276-298, 313-335, 361-383 and 398-420 550538020226 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 3.7e-83 550538020227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 550538020228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538020229 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 550538020230 putative dimerization interface [polypeptide binding]; other site 550538020231 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.1e-43 550538020232 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.2e-23 550538020233 PS00044 Bacterial regulatory proteins, lysR family signature. 550538020234 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 550538020235 HMMPfam hit to PF03788, LrgA, score 1.3e-30 550538020236 4 probable transmembrane helices predicted for SG4115 by TMHMM2.0 at aa 20-42, 47-64, 71-93 and 103-122 550538020237 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 550538020238 6 probable transmembrane helices predicted for SG4116 by TMHMM2.0 at aa 4-21, 33-54, 64-86, 93-115, 149-171 and 203-225 550538020239 HMMPfam hit to PF04172, LrgB-like protein, score 4.7e-106 550538020240 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 550538020241 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 550538020242 Na binding site [ion binding]; other site 550538020243 13 probable transmembrane helices predicted for SG4117 by TMHMM2.0 at aa 33-55, 76-98, 103-125, 146-168, 183-205, 212-234, 264-286, 298-320, 362-384, 404-423, 428-450, 462-484 and 494-516 550538020244 PS00457 Sodium:solute symporter family signature 2. 550538020245 HMMPfam hit to PF00474, Na+/solute symporter, score 1.4e-197 550538020246 PS00456 Sodium:solute symporter family signature 1. 550538020247 Predicted membrane protein [Function unknown]; Region: COG3162 550538020248 HMMPfam hit to PF04341, Protein of unknown function DUF485, score 1.3e-60 550538020249 2 probable transmembrane helices predicted for SG4118 by TMHMM2.0 at aa 25-47 and 62-84 550538020250 acetyl-CoA synthetase; Provisional; Region: PRK00174 550538020251 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 550538020252 active site 550538020253 CoA binding site [chemical binding]; other site 550538020254 acyl-activating enzyme (AAE) consensus motif; other site 550538020255 AMP binding site [chemical binding]; other site 550538020256 acetate binding site [chemical binding]; other site 550538020257 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 4.5e-141 550538020258 PS00455 AMP-binding domain signature. 550538020259 PS00018 EF-hand calcium-binding domain. 550538020260 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 550538020261 HMMPfam hit to PF02335, Cytochrome c552, score 0 550538020262 PS00190 Cytochrome c family heme-binding site signature. 550538020263 PS00190 Cytochrome c family heme-binding site signature. 550538020264 PS00190 Cytochrome c family heme-binding site signature. 550538020265 PS00190 Cytochrome c family heme-binding site signature. 550538020266 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 550538020267 PS00190 Cytochrome c family heme-binding site signature. 550538020268 PS00190 Cytochrome c family heme-binding site signature. 550538020269 PS00190 Cytochrome c family heme-binding site signature. 550538020270 PS00190 Cytochrome c family heme-binding site signature. 550538020271 PS00190 Cytochrome c family heme-binding site signature. 550538020272 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 550538020273 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0024 550538020274 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 9.1e-06 550538020275 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538020276 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 550538020277 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 550538020278 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 3.1e-148 550538020279 8 probable transmembrane helices predicted for SG4124 by TMHMM2.0 at aa 15-37, 57-76, 91-113, 151-170, 180-202, 223-241, 256-278 and 290-312 550538020280 heme lyase subunit NrfE; Provisional; Region: PRK10369 550538020281 13 probable transmembrane helices predicted for SG4125 by TMHMM2.0 at aa 13-35, 56-78, 93-115, 127-149, 183-205, 212-234, 254-271, 283-305, 315-337, 357-379, 394-416, 429-448 and 552-571 550538020282 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 4.1e-67 550538020283 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 550538020284 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 550538020285 2 probable transmembrane helices predicted for SG4126 by TMHMM2.0 at aa 30-49 and 130-149 550538020286 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 3e-42 550538020287 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 550538020288 1 probable transmembrane helix predicted for SG4127 by TMHMM2.0 at aa 20-37 550538020289 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 8.6e-05 550538020290 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 550538020291 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 550538020292 8 probable transmembrane helices predicted for SG4128 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 163-185, 206-228, 233-255, 354-376 and 391-409 550538020293 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 4.1e-223 550538020294 PS00713 Sodium:dicarboxylate symporter family signature 1. 550538020295 PS00714 Sodium:dicarboxylate symporter family signature 2. 550538020296 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 550538020297 Sel1-like repeats; Region: SEL1; smart00671 550538020298 HMMPfam hit to PF08238, Sel1-like, score 0.00082 550538020299 HMMPfam hit to PF08238, Sel1-like, score 0.0009 550538020300 HMMPfam hit to PF08238, Sel1-like, score 0.44 550538020301 HMMPfam hit to PF08238, Sel1-like, score 0.00083 550538020302 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 550538020303 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 550538020304 [4Fe-4S] binding site [ion binding]; other site 550538020305 molybdopterin cofactor binding site; other site 550538020306 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 550538020307 molybdopterin cofactor binding site; other site 550538020308 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.3e-34 550538020309 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 550538020310 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.4e-182 550538020311 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 550538020312 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 7e-22 550538020313 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020314 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 550538020315 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 550538020316 2 probable transmembrane helices predicted for SG4131 by TMHMM2.0 at aa 4-22 and 279-301 550538020317 HMMPfam hit to PF05118, Aspartyl/Asparaginyl beta-hydroxylase, score 6e-93 550538020318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538020319 Coenzyme A binding pocket [chemical binding]; other site 550538020320 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.9e-18 550538020321 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 550538020322 dimer interface [polypeptide binding]; other site 550538020323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 550538020324 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 0.0004 550538020325 hypothetical protein; Provisional; Region: PRK10220 550538020326 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 550538020327 PhnA protein; Region: PhnA; pfam03831 550538020328 HMMPfam hit to PF03831, PhnA protein, C-terminal, score 7.7e-37 550538020329 HMMPfam hit to PF08274, PhnA protein, N-terminal, score 2.6e-17 550538020330 proline/glycine betaine transporter; Provisional; Region: PRK10642 550538020331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538020332 putative substrate translocation pore; other site 550538020333 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 550538020334 HMMPfam hit to PF00083, General substrate transporter, score 2.9e-96 550538020335 12 probable transmembrane helices predicted for SG4135 by TMHMM2.0 at aa 30-52, 67-89, 98-120, 124-146, 167-189, 199-221, 260-282, 297-319, 326-346, 351-373, 386-408 and 418-437 550538020336 PS00216 Sugar transport proteins signature 1. 550538020337 HMMPfam hit to PF08946, Osmosensory transporter coiled coil, score 3e-23 550538020338 sensor protein BasS/PmrB; Provisional; Region: PRK10755 550538020339 HAMP domain; Region: HAMP; pfam00672 550538020340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538020341 dimer interface [polypeptide binding]; other site 550538020342 phosphorylation site [posttranslational modification] 550538020343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538020344 ATP binding site [chemical binding]; other site 550538020345 Mg2+ binding site [ion binding]; other site 550538020346 G-X-G motif; other site 550538020347 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2e-27 550538020348 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.1e-11 550538020349 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1e-08 550538020350 2 probable transmembrane helices predicted for SG4136 by TMHMM2.0 at aa 13-35 and 66-88 550538020351 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 550538020352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538020353 active site 550538020354 phosphorylation site [posttranslational modification] 550538020355 intermolecular recognition site; other site 550538020356 dimerization interface [polypeptide binding]; other site 550538020357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538020358 DNA binding site [nucleotide binding] 550538020359 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 5.8e-20 550538020360 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-45 550538020361 PS00217 Sugar transport proteins signature 2. 550538020362 putative metal dependent hydrolase; Provisional; Region: PRK11598 550538020363 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 550538020364 Sulfatase; Region: Sulfatase; pfam00884 550538020365 HMMPfam hit to PF00884, Sulphatase, score 9.8e-78 550538020366 HMMPfam hit to PF08019, Protein of unknown function DUF1705, score 6.7e-71 550538020367 5 probable transmembrane helices predicted for SG4138 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 120-142 and 154-176 550538020368 arginine:agmatin antiporter; Provisional; Region: PRK10644 550538020369 11 probable transmembrane helices predicted for SG4139 by TMHMM2.0 at aa 10-32, 39-61, 94-116, 123-142, 152-173, 228-250, 274-296, 324-341, 356-378, 385-407 and 411-428 550538020370 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.4e-16 550538020371 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 550538020372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538020373 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.4e-08 550538020374 PS00041 Bacterial regulatory proteins, araC family signature. 550538020375 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.3e-06 550538020376 arginine decarboxylase; Provisional; Region: PRK15029 550538020377 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 550538020378 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 550538020379 homodimer interface [polypeptide binding]; other site 550538020380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 550538020381 catalytic residue [active] 550538020382 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 550538020383 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 1.8e-66 550538020384 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 3.9e-294 550538020385 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 550538020386 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 8.9e-39 550538020387 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 550538020388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538020389 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3e-13 550538020390 PS00041 Bacterial regulatory proteins, araC family signature. 550538020391 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9.6e-06 550538020392 alpha-galactosidase; Provisional; Region: PRK15076 550538020393 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 550538020394 NAD binding site [chemical binding]; other site 550538020395 sugar binding site [chemical binding]; other site 550538020396 divalent metal binding site [ion binding]; other site 550538020397 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 550538020398 dimer interface [polypeptide binding]; other site 550538020399 HMMPfam hit to PF02056, Glycoside hydrolase, family 4, score 1.2e-241 550538020400 PS01324 Glycosyl hydrolases family 4 signature. 550538020401 melibiose:sodium symporter; Provisional; Region: PRK10429 550538020402 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 550538020403 12 probable transmembrane helices predicted for SG4144 by TMHMM2.0 at aa 9-31, 36-58, 78-100, 110-132, 145-167, 177-199, 236-258, 268-290, 297-319, 324-346, 378-400 and 410-432 550538020404 PS00872 Sodium:galactoside symporter family signature. 550538020405 the sequence has been checked and is believed to be correct 550538020406 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 8.7e-113 550538020407 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 3.5e-146 550538020408 the sequence has been checked and is believed to be correct 550538020409 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter, score 2.7e-257 550538020410 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 550538020411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538020412 active site 550538020413 phosphorylation site [posttranslational modification] 550538020414 intermolecular recognition site; other site 550538020415 dimerization interface [polypeptide binding]; other site 550538020416 HMMPfam hit to PF00072, Response regulator receiver, score 1.5e-24 550538020417 sensory histidine kinase DcuS; Provisional; Region: PRK11086 550538020418 PAS domain; Region: PAS; smart00091 550538020419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538020420 ATP binding site [chemical binding]; other site 550538020421 Mg2+ binding site [ion binding]; other site 550538020422 G-X-G motif; other site 550538020423 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.2e-31 550538020424 HMMPfam hit to PF00989, PAS fold, score 1.4e-16 550538020425 2 probable transmembrane helices predicted for SG4149 by TMHMM2.0 at aa 20-42 and 183-202 550538020426 the sequence has been checked and is believed to be correct, similar to many proposed anaerobic dimethyl sulfoxide reductases 550538020427 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 1.7e-08 550538020428 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.3e-104 550538020429 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 2.2e-33 550538020430 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 550538020431 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.9e-06 550538020432 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538020433 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 550538020434 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 3.9e-16 550538020435 8 probable transmembrane helices predicted for SG4152 by TMHMM2.0 at aa 10-32, 39-61, 81-100, 107-129, 139-161, 166-188, 203-221 and 228-250 550538020436 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 550538020437 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 4.5e-56 550538020438 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 550538020439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 550538020440 SdiA-regulated; Region: SdiA-regulated; cd09971 550538020441 putative active site [active] 550538020442 1 probable transmembrane helix predicted for SG4155 by TMHMM2.0 at aa 13-35 550538020443 HMMPfam hit to PF06977, SdiA-regulated, score 6.8e-48 550538020444 the sequence has been checked and is believed to be correct 550538020445 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 550538020446 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 550538020447 DNA binding residues [nucleotide binding] 550538020448 dimerization interface [polypeptide binding]; other site 550538020449 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.4e-05 550538020450 AraC family transcriptional regulator; Provisional; Region: PRK15186 550538020451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538020452 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.3e-11 550538020453 PS00041 Bacterial regulatory proteins, araC family signature. 550538020454 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.0016 550538020455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 550538020456 HMMPfam hit to PF08681, Protein of unknown function DUF1778, score 1.5e-27 550538020457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538020458 Coenzyme A binding pocket [chemical binding]; other site 550538020459 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 7.1e-05 550538020460 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 550538020461 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 550538020462 active site 550538020463 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 1.8e-23 550538020464 PS00018 EF-hand calcium-binding domain. 550538020465 PS01157 Class A bacterial acid phosphatases signature. 550538020466 putative transcriptional regulator; Provisional; Region: PRK11640 550538020467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 550538020468 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 4.2e-06 550538020469 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 550538020470 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 550538020471 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 550538020472 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 550538020473 DsbD alpha interface [polypeptide binding]; other site 550538020474 catalytic residues [active] 550538020475 PS00194 Thioredoxin family active site. 550538020476 HMMPfam hit to PF00085, Thioredoxin domain, score 7.4e-06 550538020477 8 probable transmembrane helices predicted for SG4165 by TMHMM2.0 at aa 5-22, 170-192, 212-234, 246-268, 297-319, 326-348, 358-380 and 387-409 550538020478 HMMPfam hit to PF02683, Cytochrome c biogenesis protein, transmembrane region, score 2.2e-07 550538020479 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 550538020480 HMMPfam hit to PF03091, Divalent ion tolerance protein, CutA1, score 1.8e-58 550538020481 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 550538020482 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 550538020483 10 probable transmembrane helices predicted for SG4167 by TMHMM2.0 at aa 7-29, 49-71, 91-113, 123-145, 187-204, 219-238, 245-267, 287-306, 319-341 and 371-393 550538020484 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter, score 1.2e-198 550538020485 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 550538020486 Aspartase; Region: Aspartase; cd01357 550538020487 active sites [active] 550538020488 tetramer interface [polypeptide binding]; other site 550538020489 HMMPfam hit to PF00206, Fumarate lyase, score 9.9e-180 550538020490 PS00163 Fumarate lyases signature. 550538020491 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 550538020492 3 probable transmembrane helices predicted for SG4169 by TMHMM2.0 at aa 15-34, 39-61 and 92-114 550538020493 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 3.8e-60 550538020495 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.00022 550538020496 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 550538020497 oligomerisation interface [polypeptide binding]; other site 550538020498 mobile loop; other site 550538020499 roof hairpin; other site 550538020500 HMMPfam hit to PF00166, Chaperonin Cpn10, score 7.9e-42 550538020501 PS00681 Chaperonins cpn10 signature. 550538020502 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 550538020503 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 550538020504 ring oligomerisation interface [polypeptide binding]; other site 550538020505 ATP/Mg binding site [chemical binding]; other site 550538020506 stacking interactions; other site 550538020507 hinge regions; other site 550538020508 HMMPfam hit to PF00118, Chaperonin Cpn60/TCP-1, score 5.3e-191 550538020509 PS00296 Chaperonins cpn60 signature. 550538020510 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 550538020511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020512 the sequence has been checked and is believed to be correct 550538020513 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 550538020514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538020515 FeS/SAM binding site; other site 550538020516 HMMPfam hit to PF04055, Radical SAM, score 2.6e-08 550538020517 elongation factor P; Validated; Region: PRK00529 550538020518 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 550538020519 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 550538020520 RNA binding site [nucleotide binding]; other site 550538020521 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 550538020522 RNA binding site [nucleotide binding]; other site 550538020523 HMMPfam hit to PF08207, Translation elongation factor, KOW-like, score 5.8e-32 550538020524 HMMPfam hit to PF01132, Translation elongation factor P/YeiP, central, score 3.2e-32 550538020525 HMMPfam hit to PF09285, Elongation factor P, C-terminal, score 4e-35 550538020526 PS01275 Elongation factor P signature. 550538020527 Predicted small secreted protein [Function unknown]; Region: COG5510 550538020528 HMMPfam hit to PF08085, Entericidin EcnAB, score 2.6e-22 550538020529 1 probable transmembrane helix predicted for SG4178 by TMHMM2.0 at aa 5-27 550538020530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020531 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 550538020532 HMMPfam hit to PF08085, Entericidin EcnAB, score 1e-20 550538020533 1 probable transmembrane helix predicted for SG4179 by TMHMM2.0 at aa 7-29 550538020534 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 550538020536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538020537 DNA binding residues [nucleotide binding] 550538020538 dimerization interface [polypeptide binding]; other site 550538020539 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.7e-12 550538020540 PS00622 Bacterial regulatory proteins, luxR family signature. 550538020541 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020542 multidrug efflux system protein; Provisional; Region: PRK11431 550538020543 HMMPfam hit to PF00893, Small multidrug resistance protein, score 4.4e-47 550538020544 4 probable transmembrane helices predicted for SG4181 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 87-104 550538020545 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 550538020546 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 550538020547 HMMPfam hit to PF08212, Lipocalin-like, score 3.4e-81 550538020548 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538020549 PS00213 Lipocalin signature. 550538020550 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020551 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 550538020552 Iron-sulfur protein interface; other site 550538020553 proximal quinone binding site [chemical binding]; other site 550538020554 C-subunit interface; other site 550538020555 distal quinone binding site; other site 550538020556 HMMPfam hit to PF02313, Fumarate reductase, D subunit, score 1.3e-82 550538020557 3 probable transmembrane helices predicted for SG4183 by TMHMM2.0 at aa 13-42, 57-79 and 99-118 550538020558 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538020559 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 550538020560 D-subunit interface [polypeptide binding]; other site 550538020561 Iron-sulfur protein interface; other site 550538020562 proximal quinone binding site [chemical binding]; other site 550538020563 HMMPfam hit to PF02300, Fumarate reductase, subunit C, score 6.6e-98 550538020564 3 probable transmembrane helices predicted for SG4184 by TMHMM2.0 at aa 28-50, 60-82 and 108-130 550538020565 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 550538020566 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 550538020567 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00083 550538020568 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538020569 HMMPfam hit to PF00111, Ferredoxin, score 0.063 550538020570 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 550538020571 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 550538020572 L-aspartate oxidase; Provisional; Region: PRK06175 550538020573 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 550538020574 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 5.2e-70 550538020575 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 2.9e-158 550538020576 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 550538020577 poxB regulator PoxA; Provisional; Region: PRK09350 550538020578 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 550538020579 motif 1; other site 550538020580 dimer interface [polypeptide binding]; other site 550538020581 active site 550538020582 motif 2; other site 550538020583 motif 3; other site 550538020584 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 2e-74 550538020585 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 550538020586 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 550538020587 inner membrane transporter YjeM; Provisional; Region: PRK15238 550538020588 12 probable transmembrane helices predicted for SG4188 by TMHMM2.0 at aa 12-34, 38-57, 95-117, 132-154, 161-183, 208-230, 243-265, 310-332, 364-383, 393-415, 435-457 and 467-484 550538020589 HMMPfam hit to PF00324, Amino acid permease-associated region, score 5.5e-07 550538020590 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 550538020591 3 probable transmembrane helices predicted for SG4189 by TMHMM2.0 at aa 7-26, 55-72 and 79-98 550538020592 putative mechanosensitive channel protein; Provisional; Region: PRK10929 550538020593 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 550538020594 Mechanosensitive ion channel; Region: MS_channel; pfam00924 550538020595 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.1e-79 550538020596 PS01246 Uncharacterized protein family UPF0003 signature. 550538020597 11 probable transmembrane helices predicted for SG4190 by TMHMM2.0 at aa 475-492, 521-543, 553-575, 596-617, 627-648, 669-691, 696-718, 784-806, 826-848, 879-898 and 908-930 550538020598 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 550538020599 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase-related, score 2.5e-114 550538020600 GTPase RsgA; Reviewed; Region: PRK12288 550538020601 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 550538020602 RNA binding site [nucleotide binding]; other site 550538020603 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 550538020604 GTPase/Zn-binding domain interface [polypeptide binding]; other site 550538020605 GTP/Mg2+ binding site [chemical binding]; other site 550538020606 G4 box; other site 550538020607 G5 box; other site 550538020608 G1 box; other site 550538020609 Switch I region; other site 550538020610 G2 box; other site 550538020611 G3 box; other site 550538020612 Switch II region; other site 550538020613 HMMPfam hit to PF03193, GTPase EngC, score 5.2e-147 550538020614 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020615 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 550538020616 catalytic site [active] 550538020617 putative active site [active] 550538020618 putative substrate binding site [chemical binding]; other site 550538020619 dimer interface [polypeptide binding]; other site 550538020620 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 6.1e-36 550538020621 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 550538020622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 550538020623 substrate binding pocket [chemical binding]; other site 550538020624 membrane-bound complex binding site; other site 550538020625 hinge residues; other site 550538020626 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 9.7e-87 550538020627 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 550538020628 epoxyqueuosine reductase; Region: TIGR00276 550538020629 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 550538020630 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0015 550538020631 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538020632 HMMPfam hit to PF08331, Region of unknown function DUF1730, score 7.2e-40 550538020634 HMMPfam hit to PF03853, YjeF-related protein, N-terminal, score 5e-67 550538020635 HMMPfam hit to PF01256, Carbohydrate kinase, score 4.1e-110 550538020636 ADP-binding protein; Provisional; Region: PRK10646 550538020637 HMMPfam hit to PF02367, Protein of unknown function UPF0079, ATPase bacteria, score 7.6e-70 550538020638 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020639 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 550538020640 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 550538020641 active site 550538020642 metal binding site [ion binding]; metal-binding site 550538020643 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 8e-99 550538020644 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 550538020645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538020646 ATP binding site [chemical binding]; other site 550538020647 Mg2+ binding site [ion binding]; other site 550538020648 G-X-G motif; other site 550538020649 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 550538020650 ATP binding site [chemical binding]; other site 550538020651 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 550538020652 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.2e-10 550538020653 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 550538020654 HMMPfam hit to PF01119, DNA mismatch repair protein, C-terminal, score 5.7e-48 550538020655 HMMPfam hit to PF08676, MutL, C-terminal, dimerisation, score 2.9e-25 550538020656 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 550538020657 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 550538020658 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020659 HMMPfam hit to PF01715, tRNA isopentenyltransferase, score 5.6e-159 550538020660 bacterial Hfq-like; Region: Hfq; cd01716 550538020661 hexamer interface [polypeptide binding]; other site 550538020662 Sm1 motif; other site 550538020663 RNA binding site [nucleotide binding]; other site 550538020664 Sm2 motif; other site 550538020665 HMMPfam hit to PF01423, Like-Sm ribonucleoprotein, core, score 3.9e-12 550538020666 GTPase HflX; Provisional; Region: PRK11058 550538020667 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 550538020668 HflX GTPase family; Region: HflX; cd01878 550538020669 G1 box; other site 550538020670 GTP/Mg2+ binding site [chemical binding]; other site 550538020671 Switch I region; other site 550538020672 G2 box; other site 550538020673 G3 box; other site 550538020674 Switch II region; other site 550538020675 G4 box; other site 550538020676 G5 box; other site 550538020677 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.4e-39 550538020678 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020679 FtsH protease regulator HflK; Provisional; Region: PRK10930 550538020680 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 550538020681 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 550538020682 1 probable transmembrane helix predicted for SG4204 by TMHMM2.0 at aa 78-100 550538020683 HMMPfam hit to PF01145, Band 7 protein, score 1.1e-54 550538020684 FtsH protease regulator HflC; Provisional; Region: PRK11029 550538020685 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 550538020686 1 probable transmembrane helix predicted for SG4205 by TMHMM2.0 at aa 5-23 550538020687 HMMPfam hit to PF01145, Band 7 protein, score 2.4e-64 550538020688 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 550538020689 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 550538020690 GDP-binding site [chemical binding]; other site 550538020691 ACT binding site; other site 550538020692 IMP binding site; other site 550538020693 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 0 550538020694 PS01266 Adenylosuccinate synthetase GTP-binding site. 550538020695 PS00513 Adenylosuccinate synthetase active site. 550538020696 Predicted transcriptional regulator [Transcription]; Region: COG1959 550538020697 transcriptional repressor NsrR; Provisional; Region: PRK11014 550538020698 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 3.8e-46 550538020699 exoribonuclease R; Provisional; Region: PRK11642 550538020700 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 550538020701 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 550538020702 RNB domain; Region: RNB; pfam00773 550538020703 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 550538020704 RNA binding site [nucleotide binding]; other site 550538020705 HMMPfam hit to PF08461, Ribonuclease R winged-helix domain, score 5.7e-24 550538020706 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 5e-29 550538020707 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 0.00024 550538020708 HMMPfam hit to PF00773, Ribonuclease II and R, score 2.9e-155 550538020709 PS01175 Ribonuclease II family signature. 550538020710 HMMPfam hit to PF00575, S1, RNA binding, score 6.2e-22 550538020711 PS00017 ATP/GTP-binding site motif A (P-loop). 550538020712 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 550538020713 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 550538020714 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 550538020715 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate binding, score 6e-22 550538020716 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 4.4e-64 550538020717 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 550538020718 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 550538020719 HMMPfam hit to PF04012, PspA/IM30, score 2.5e-69 550538020720 Ion channel; Region: Ion_trans_2; pfam07885 550538020721 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 550538020722 3 probable transmembrane helices predicted for SG4212 by TMHMM2.0 at aa 15-37, 44-66 and 81-100 550538020723 HMMPfam hit to PF07885, Ion transport 2, score 2.8e-10 550538020724 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 550538020726 HMMPfam hit to PF03994, Protein of unknown function DUF350, score 5.4e-21 550538020727 HMMPfam hit to PF03994, Protein of unknown function DUF350, score 2.9e-16 550538020728 Predicted integral membrane protein [Function unknown]; Region: COG5463 550538020729 HMMPfam hit to PF06693, Protein of unknown function DUF1190, score 2.1e-173 550538020730 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 550538020731 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 2.7e-249 550538020732 PS00107 Protein kinases ATP-binding region signature. 550538020734 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 1.3e-41 550538020735 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase/oxidase, central region, score 2.3e-13 550538020736 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 9.2e-34 550538020737 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538020738 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 3.5e-49 550538020739 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 550538020740 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.4e-05 550538020741 1 probable transmembrane helix predicted for SG4221 by TMHMM2.0 at aa 13-32 550538020742 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020743 esterase; Provisional; Region: PRK10566 550538020744 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 550538020745 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 550538020746 transcriptional repressor UlaR; Provisional; Region: PRK13509 550538020747 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 550538020748 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 550538020749 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 2.2e-64 550538020750 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 6e-26 550538020751 PS00894 Bacterial regulatory proteins, deoR family signature. 550538020752 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 550538020753 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 550538020754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 550538020755 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 550538020756 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 8.2e-279 550538020757 10 probable transmembrane helices predicted for SG4225 by TMHMM2.0 at aa 15-34, 41-63, 100-122, 143-172, 233-252, 264-286, 306-328, 340-362, 377-399 and 424-446 550538020758 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 550538020759 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 550538020760 active site 550538020761 P-loop; other site 550538020762 phosphorylation site [posttranslational modification] 550538020763 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 8.9e-34 550538020764 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538020765 active site 550538020766 phosphorylation site [posttranslational modification] 550538020767 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 1.3e-74 550538020768 PS00372 PTS EIIA domains phosphorylation site signature 2. 550538020769 PS00387 Inorganic pyrophosphatase signature. 550538020770 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 550538020771 active site 550538020772 dimer interface [polypeptide binding]; other site 550538020773 magnesium binding site [ion binding]; other site 550538020774 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 4.3e-62 550538020775 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 550538020776 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 550538020777 AP (apurinic/apyrimidinic) site pocket; other site 550538020778 DNA interaction; other site 550538020779 Metal-binding active site; metal-binding site 550538020780 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 6.4e-44 550538020781 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 550538020782 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 550538020783 intersubunit interface [polypeptide binding]; other site 550538020784 active site 550538020785 Zn2+ binding site [ion binding]; other site 550538020786 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 5.4e-99 550538020787 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 550538020788 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.1e-28 550538020789 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 550538020790 HMMPfam hit to PF01250, Ribosomal protein S6, score 2.2e-50 550538020791 PS01048 Ribosomal protein S6 signature. 550538020792 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 550538020793 dimer interface [polypeptide binding]; other site 550538020794 ssDNA binding site [nucleotide binding]; other site 550538020795 tetramer (dimer of dimers) interface [polypeptide binding]; other site 550538020796 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 1.6e-16 550538020797 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 550538020798 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.3e-32 550538020799 PS00057 Ribosomal protein S18 signature. 550538020800 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 550538020801 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 550538020802 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 550538020803 HMMPfam hit to PF01281, Ribosomal protein L9, score 6.5e-27 550538020804 PS00651 Ribosomal protein L9 signature. 550538020805 HMMPfam hit to PF03948, Ribosomal protein L9, score 4.6e-45 550538020806 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 550538020807 EamA-like transporter family; Region: EamA; pfam00892 550538020808 10 probable transmembrane helices predicted for SG4237 by TMHMM2.0 at aa 13-34, 54-72, 85-107, 117-134, 141-163, 173-192, 204-226, 231-253, 258-280 and 284-303 550538020809 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 5.3e-13 550538020810 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 6.9e-12 550538020811 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 550538020812 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 550538020813 HMMPfam hit to PF04225, Opacity-associated protein A, score 1.2e-56 550538020814 HMMPfam hit to PF08525, Opacity-associated protein A, N-terminal, score 1.6e-08 550538020815 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 550538020816 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 550538020817 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 550538020818 HMMPfam hit to PF01346, Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal, score 2.8e-06 550538020819 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 7.9e-47 550538020820 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 550538020821 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 550538020822 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 550538020823 HMMPfam hit to PF00324, Amino acid permease-associated region, score 5.7e-170 550538020824 12 probable transmembrane helices predicted for SG4240 by TMHMM2.0 at aa 27-44, 49-71, 104-126, 136-158, 165-187, 210-232, 252-274, 289-311, 347-369, 374-396, 417-436 and 441-460 550538020825 PS00218 Amino acid permeases signature. 550538020826 DKNYY family; Region: DKNYY; pfam13644 550538020827 1 probable transmembrane helix predicted for SG4242 by TMHMM2.0 at aa 7-29 550538020828 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538020829 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 550538020830 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 550538020831 Hemerythrin-like domain; Region: Hr-like; cd12108 550538020832 Fe binding site [ion binding]; other site 550538020833 HMMPfam hit to PF01814, Hemerythrin HHE cation binding region, score 0.00018 550538020834 HMMPfam hit to PF01814, Hemerythrin HHE cation binding region, score 1.4e-06 550538020835 HMMPfam hit to PF04405, Protein of unknown function DUF542, ScdA N-terminal, score 2.9e-37 550538020836 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 550538020837 EamA-like transporter family; Region: EamA; pfam00892 550538020838 10 probable transmembrane helices predicted for SG4245 by TMHMM2.0 at aa 5-25, 35-52, 64-86, 91-113, 120-142, 152-174, 195-217, 232-254, 259-281 and 286-308 550538020839 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 8.1e-09 550538020840 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 550538020841 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 550538020842 NADP binding site [chemical binding]; other site 550538020843 HMMPfam hit to PF05368, NmrA-like, score 1.6e-09 550538020844 Predicted transcriptional regulators [Transcription]; Region: COG1733 550538020845 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 550538020846 HMMPfam hit to PF01638, Helix-turn-helix, HxlR type, score 6.9e-53 550538020847 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 550538020848 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 550538020849 active site 550538020850 metal binding site [ion binding]; metal-binding site 550538020851 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 550538020852 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 2.5e-64 550538020853 HMMPfam hit to PF00149, Metallophosphoesterase, score 1.9e-19 550538020854 PS00786 5'-nucleotidase signature 2. 550538020855 PS00785 5'-nucleotidase signature 1. 550538020856 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 550538020857 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 550538020858 active site 550538020859 HMMPfam hit to PF00459, Inositol monophosphatase, score 3.9e-75 550538020860 PS00629 Inositol monophosphatase family signature 1. 550538020861 PS00630 Inositol monophosphatase family signature 2. 550538020862 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 550538020863 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 550538020864 HMMPfam hit to PF06526, Protein of unknown function DUF1107, score 2.8e-47 550538020865 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 550538020866 Domain of unknown function DUF21; Region: DUF21; pfam01595 550538020867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 550538020868 Transporter associated domain; Region: CorC_HlyC; smart01091 550538020869 HMMPfam hit to PF03471, Transporter-associated region, score 1.1e-24 550538020870 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.6e-15 550538020871 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 1.4e-71 550538020872 4 probable transmembrane helices predicted for SG4252 by TMHMM2.0 at aa 5-27, 58-80, 100-117 and 144-162 550538020873 methionine sulfoxide reductase A; Provisional; Region: PRK00058 550538020874 HMMPfam hit to PF01625, Methionine sulphoxide reductase A, score 4.2e-106 550538020875 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 550538020876 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 550538020877 Surface antigen; Region: Bac_surface_Ag; pfam01103 550538020878 HMMPfam hit to PF07244, Surface antigen variable number, score 4.3e-11 550538020879 HMMPfam hit to PF01103, Bacterial surface antigen (D15), score 8.4e-80 550538020880 PS00213 Lipocalin signature. 550538020881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 550538020882 Family of unknown function (DUF490); Region: DUF490; pfam04357 550538020883 1 probable transmembrane helix predicted for SG4255 by TMHMM2.0 at aa 7-29 550538020884 PS00213 Lipocalin signature. 550538020885 HMMPfam hit to PF04357, Protein of unknown function DUF490, score 1.3e-164 550538020886 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 550538020887 putative active site pocket [active] 550538020888 dimerization interface [polypeptide binding]; other site 550538020889 putative catalytic residue [active] 550538020890 HMMPfam hit to PF03674, Protein of unknown function UPF0131, score 3.8e-51 550538020891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538020892 D-galactonate transporter; Region: 2A0114; TIGR00893 550538020893 putative substrate translocation pore; other site 550538020894 12 probable transmembrane helices predicted for SG4257 by TMHMM2.0 at aa 7-26, 41-63, 76-93, 97-116, 137-154, 164-186, 215-237, 252-273, 280-302, 307-329, 342-364 and 369-391 550538020895 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 1.3e-54 550538020896 the sequence has been checked and is believed to be correct 550538020897 HMMPfam hit to PF07969, Amidohydrolase 3, score 0.00017 550538020898 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 550538020899 dimer interface [polypeptide binding]; other site 550538020900 substrate binding site [chemical binding]; other site 550538020901 metal binding sites [ion binding]; metal-binding site 550538020902 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 1.4e-61 550538020903 PS00387 Inorganic pyrophosphatase signature. 550538020904 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 550538020905 AMP binding site [chemical binding]; other site 550538020906 metal binding site [ion binding]; metal-binding site 550538020907 active site 550538020908 HMMPfam hit to PF00316, Inositol phosphatase/fructose-1,6-bisphosphatase, score 1.3e-218 550538020909 PS00124 Fructose-1-6-bisphosphatase active site. 550538020910 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 550538020911 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 550538020912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 550538020913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 550538020914 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 5.4e-31 550538020915 HMMPfam hit to PF08245, Mur ligase, central, score 1.5e-09 550538020916 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 4.2e-07 550538020917 hypothetical protein; Provisional; Region: PRK05255 550538020918 HMMPfam hit to PF04751, Protein of unknown function DUF615, score 2.6e-116 550538020919 peptidase PmbA; Provisional; Region: PRK11040 550538020920 HMMPfam hit to PF01523, Peptidase U62, modulator of DNA gyrase, score 3.7e-101 550538020921 cytochrome b562; Provisional; Region: PRK15058 550538020922 1 probable transmembrane helix predicted for SG4264 by TMHMM2.0 at aa 5-23 550538020923 HMMPfam hit to PF07361, Cytochrome b562, score 3.6e-58 550538020924 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 550538020925 HMMPfam hit to PF00874, PRD, score 2.5e-16 550538020926 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 550538020927 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 550538020928 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 550538020929 6 probable transmembrane helices predicted for SG4268 by TMHMM2.0 at aa 2-24, 55-77, 111-133, 143-165, 177-199 and 214-232 550538020930 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 550538020931 6 probable transmembrane helices predicted for SG4269 by TMHMM2.0 at aa 15-37, 57-74, 84-106, 111-133, 165-187 and 194-213 550538020932 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 550538020933 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 550538020934 active site 550538020935 HMMPfam hit to PF01979, Amidohydrolase 1, score 0.00015 550538020936 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 550538020937 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 550538020938 HMMPfam hit to PF01212, Aromatic amino acid beta-eliminating lyase/threonine aldolase, score 3.9e-05 550538020939 the sequence has been checked and is believed to be correct 550538020940 HMMPfam hit to PF07071, Protein of unknown function DUF1341, score 1.5e-159 550538020941 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 550538020942 HTH domain; Region: HTH_11; pfam08279 550538020943 Mga helix-turn-helix domain; Region: Mga; pfam05043 550538020944 PRD domain; Region: PRD; pfam00874 550538020945 PRD domain; Region: PRD; pfam00874 550538020946 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 550538020947 active site 550538020948 P-loop; other site 550538020949 phosphorylation site [posttranslational modification] 550538020950 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 550538020951 active site 550538020952 phosphorylation site [posttranslational modification] 550538020953 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1.2e-15 550538020954 PS00894 Bacterial regulatory proteins, deoR family signature. 550538020955 HMMPfam hit to PF05043, M trans-acting positive regulator, score 7.4e-06 550538020956 HMMPfam hit to PF00874, PRD, score 1.4e-15 550538020957 HMMPfam hit to PF00874, PRD, score 3.5e-16 550538020958 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 4e-05 550538020959 PS00372 PTS EIIA domains phosphorylation site signature 2. 550538020960 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 550538020961 HMMPfam hit to PF04221, RelB antitoxin, score 9.4e-14 550538020962 PS00215 Mitochondrial energy transfer proteins signature. 550538020963 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 550538020964 HMMPfam hit to PF05016, Plasmid stabilization system, score 1.3e-16 550538020965 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 550538020966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538020967 FeS/SAM binding site; other site 550538020968 PS01087 Radical activating enzymes signature. 550538020969 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 550538020970 ATP cone domain; Region: ATP-cone; pfam03477 550538020971 Class III ribonucleotide reductase; Region: RNR_III; cd01675 550538020972 effector binding site; other site 550538020973 active site 550538020974 Zn binding site [ion binding]; other site 550538020975 glycine loop; other site 550538020976 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 2.5e-57 550538020977 PS00850 Glycine radical signature. 550538020978 HMMPfam hit to PF03477, ATP-cone, score 8.3e-31 550538020979 the sequence has been checked and is believed to be correct 550538020980 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 6.7e-144 550538020981 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 550538020982 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 550538020983 active site turn [active] 550538020984 phosphorylation site [posttranslational modification] 550538020985 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 550538020986 10 probable transmembrane helices predicted for SG4280 by TMHMM2.0 at aa 106-128, 156-178, 185-207, 227-244, 256-278, 298-320, 341-360, 370-392, 405-427 and 437-459 550538020987 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.1e-28 550538020988 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 3.8e-10 550538020989 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 550538020990 trehalose repressor; Provisional; Region: treR; PRK09492 550538020991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538020992 DNA binding site [nucleotide binding] 550538020993 domain linker motif; other site 550538020994 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 550538020995 dimerization interface [polypeptide binding]; other site 550538020996 ligand binding site [chemical binding]; other site 550538020997 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.3e-05 550538020998 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 8.5e-13 550538020999 PS00356 Bacterial regulatory proteins, lacI family signature. 550538021000 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 550538021001 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 550538021002 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 550538021003 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 550538021004 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 550538021005 Soluble P-type ATPase [General function prediction only]; Region: COG4087 550538021006 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 550538021007 HMMPfam hit to PF00690, ATPase, P-type cation-transporter, N-terminal, score 6.1e-17 550538021008 8 probable transmembrane helices predicted for SG4282 by TMHMM2.0 at aa 122-141, 295-314, 324-346, 714-736, 773-795, 808-827, 842-864 and 869-891 550538021009 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 5.3e-95 550538021010 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.8e-16 550538021011 PS00154 E1-E2 ATPases phosphorylation site. 550538021012 the sequence has been checked and is believed to be correct 550538021013 HMMPfam hit to PF01527, Transposase IS3/IS911, score 8.9e-06 550538021014 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 550538021015 homotrimer interaction site [polypeptide binding]; other site 550538021016 putative active site [active] 550538021017 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 2.3e-63 550538021018 PS01094 Uncharacterized protein family UPF0076 signature. 550538021019 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 550538021020 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 550538021021 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 550538021022 HMMPfam hit to PF02748, Aspartate transcarbamylase regulatory subunit, score 6e-30 550538021023 HMMPfam hit to PF01948, Aspartate transcarbamylase regulatory subunit, score 9.9e-66 550538021024 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 550538021025 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 550538021026 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 550538021027 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 4.9e-65 550538021028 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 3.6e-78 550538021029 PS00097 Aspartate and ornithine carbamoyltransferases signature. 550538021030 pyrBI operon leader peptide; Provisional; Region: PRK10224 550538021031 HMMPfam hit to PF08052, PyrBI operon leader peptide, score 5.2e-14 550538021032 Arginine repressor [Transcription]; Region: ArgR; COG1438 550538021033 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 550538021034 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 550538021035 HMMPfam hit to PF02863, Arginine repressor, score 9.1e-27 550538021036 HMMPfam hit to PF01316, Arginine repressor, score 3.6e-10 550538021037 Predicted membrane protein [Function unknown]; Region: COG1288 550538021038 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 550538021039 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 9.9e-152 550538021040 11 probable transmembrane helices predicted for SG4289 by TMHMM2.0 at aa 7-29, 76-98, 121-140, 162-184, 205-222, 263-285, 290-307, 322-339, 371-393, 413-435 and 442-464 550538021041 ornithine carbamoyltransferase; Validated; Region: PRK02102 550538021042 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 550538021043 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 550538021044 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 2.5e-86 550538021045 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 3e-78 550538021046 PS00097 Aspartate and ornithine carbamoyltransferases signature. 550538021047 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 550538021048 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 550538021049 putative substrate binding site [chemical binding]; other site 550538021050 nucleotide binding site [chemical binding]; other site 550538021051 nucleotide binding site [chemical binding]; other site 550538021052 homodimer interface [polypeptide binding]; other site 550538021053 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.7e-85 550538021054 the sequence has been checked and is believed to be correct 550538021055 HMMPfam hit to PF02274, Amidinotransferase, score 7.1e-174 550538021056 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 550538021057 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 1e-68 550538021058 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 550538021059 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 550538021060 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 550538021061 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 1.5e-98 550538021062 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 1.6e-82 550538021063 PS00097 Aspartate and ornithine carbamoyltransferases signature. 550538021064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 550538021065 RNase E inhibitor protein; Provisional; Region: PRK11191 550538021066 HMMPfam hit to PF06877, Protein of unknown function DUF1260, score 1.2e-47 550538021067 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 550538021068 active site 550538021069 dinuclear metal binding site [ion binding]; other site 550538021070 dimerization interface [polypeptide binding]; other site 550538021071 HMMPfam hit to PF06175, tRNA--hydroxylase, score 1.9e-194 550538021072 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 550538021073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 550538021074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538021075 Coenzyme A binding pocket [chemical binding]; other site 550538021076 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 9.4e-20 550538021077 Predicted membrane protein [Function unknown]; Region: COG4269 550538021078 HMMPfam hit to PF05987, Protein of unknown function DUF898, transmembrane bacterial, score 5.5e-229 550538021079 8 probable transmembrane helices predicted for SG4299 by TMHMM2.0 at aa 24-46, 67-89, 99-121, 142-164, 169-191, 229-251, 281-303 and 324-346 550538021080 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 550538021081 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 550538021082 HIGH motif; other site 550538021083 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 550538021084 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 550538021085 active site 550538021086 KMSKS motif; other site 550538021087 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 550538021088 tRNA binding surface [nucleotide binding]; other site 550538021089 anticodon binding site; other site 550538021090 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 550538021091 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 6e-68 550538021092 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 0 550538021093 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538021094 DNA polymerase III subunit chi; Validated; Region: PRK05728 550538021095 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 3.1e-78 550538021096 multifunctional aminopeptidase A; Provisional; Region: PRK00913 550538021097 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 550538021098 interface (dimer of trimers) [polypeptide binding]; other site 550538021099 Substrate-binding/catalytic site; other site 550538021100 Zn-binding sites [ion binding]; other site 550538021101 HMMPfam hit to PF00883, Peptidase M17, leucyl aminopeptidase, C-terminal, score 1.9e-208 550538021102 PS00631 Cytosol aminopeptidase signature. 550538021103 HMMPfam hit to PF02789, Peptidase M17, leucyl aminopeptidase, N-terminal, score 1.1e-43 550538021104 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 550538021105 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 550538021106 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ, score 4.2e-77 550538021107 6 probable transmembrane helices predicted for SG4303 by TMHMM2.0 at aa 17-39, 54-76, 97-119, 267-289, 296-313 and 328-348 550538021108 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 550538021109 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 550538021110 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ, score 2.1e-93 550538021111 6 probable transmembrane helices predicted for SG4304 by TMHMM2.0 at aa 10-32, 64-83, 103-125, 279-301, 305-322 and 329-351 550538021112 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 550538021113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 550538021114 DNA binding site [nucleotide binding] 550538021115 domain linker motif; other site 550538021116 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 550538021117 putative dimerization interface [polypeptide binding]; other site 550538021118 putative ligand binding site [chemical binding]; other site 550538021119 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.6e-08 550538021120 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4.7e-11 550538021121 PS00356 Bacterial regulatory proteins, lacI family signature. 550538021122 gluconate transporter; Region: gntP; TIGR00791 550538021123 fructuronate transporter; Provisional; Region: PRK10034; cl15264 550538021124 11 probable transmembrane helices predicted for SG4306 by TMHMM2.0 at aa 20-42, 66-88, 92-114, 138-160, 186-208, 221-243, 258-279, 291-313, 317-339, 346-368 and 383-405 550538021125 HMMPfam hit to PF02447, Gluconate transporter, score 3.2e-246 550538021126 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 550538021127 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 550538021128 NADP binding site [chemical binding]; other site 550538021129 homodimer interface [polypeptide binding]; other site 550538021130 active site 550538021131 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 8.1e-34 550538021132 PS00061 Short-chain dehydrogenases/reductases family signature. 550538021133 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 550538021134 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 550538021135 putative NAD(P) binding site [chemical binding]; other site 550538021136 catalytic Zn binding site [ion binding]; other site 550538021137 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 5.1e-33 550538021138 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 5.9e-42 550538021139 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 550538021140 ATP-binding site [chemical binding]; other site 550538021141 Gluconate-6-phosphate binding site [chemical binding]; other site 550538021142 Shikimate kinase; Region: SKI; pfam01202 550538021143 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021144 HMMPfam hit to PF01202, Shikimate kinase, score 3.1e-06 550538021145 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 550538021146 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 550538021147 putative NAD(P) binding site [chemical binding]; other site 550538021148 putative substrate binding site [chemical binding]; other site 550538021149 catalytic Zn binding site [ion binding]; other site 550538021150 structural Zn binding site [ion binding]; other site 550538021151 dimer interface [polypeptide binding]; other site 550538021152 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 2.5e-33 550538021153 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 550538021154 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.3e-39 550538021155 PS00059 Zinc-containing alcohol dehydrogenases signature. 550538021156 PS00190 Cytochrome c family heme-binding site signature. 550538021157 Salmonella Pathogenicity Island 10: SPI-10 degenerate 550538021159 Note this CDS carries a premature stop codon and appears to have suffered a deletion event removing the C-terminal region 550538021160 Predicted transcriptional regulator [Transcription]; Region: COG3905 550538021161 HMMPfam hit to PF01402, CopG-like DNA-binding, score 1.6e-06 550538021162 PS00018 EF-hand calcium-binding domain. 550538021163 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 550538021164 HMMPfam hit to PF07362, Post-segregation antitoxin CcdA, score 4.1e-19 550538021165 CcdB protein; Region: CcdB; pfam01845 550538021166 HMMPfam hit to PF01845, CcdB protein, score 2.1e-18 550538021168 the sequence has been checked and is believed to be correct 550538021169 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.7e-42 550538021170 fimbrial operon sef 550538021171 fimbrial protein SefA; Provisional; Region: PRK15228 550538021172 HMMPfam hit to PF06443, SEF14-like adhesin, score 3.8e-124 550538021173 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 550538021174 1 probable transmembrane helix predicted for SG4318 by TMHMM2.0 at aa 7-26 550538021175 putative fimbrial chaperone protein SefB; Provisional; Region: PRK15233 550538021176 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 550538021177 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 550538021178 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1.5e-67 550538021179 PS00635 Gram-negative pili assembly chaperone signature. 550538021180 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 7.3e-26 550538021181 the sequence has been checked and is believed to be correct 550538021182 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538021183 the sequence has been checked and is believed to be correct 550538021184 HMMPfam hit to PF05775, Enterobacteria AfaD invasin, score 1e-81 550538021185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 550538021186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538021187 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.1e-09 550538021188 PS00041 Bacterial regulatory proteins, araC family signature. 550538021189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538021190 DNA binding residues [nucleotide binding] 550538021191 dimerization interface [polypeptide binding]; other site 550538021192 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.3e-06 550538021193 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 550538021194 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 550538021195 catalytic residues [active] 550538021196 hinge region; other site 550538021197 alpha helical domain; other site 550538021198 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.1e-41 550538021199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 550538021200 SdiA-regulated; Region: SdiA-regulated; cd09971 550538021201 putative active site [active] 550538021202 1 probable transmembrane helix predicted for SG4325 by TMHMM2.0 at aa 12-34 550538021203 HMMPfam hit to PF06977, SdiA-regulated, score 5e-42 550538021204 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 550538021205 DNA-binding interface [nucleotide binding]; DNA binding site 550538021206 HMMPfam hit to PF01527, Transposase IS3/IS911, score 9.2e-28 550538021207 Note appears to have lost the very N-terminal region and carries a premature stop codon 550538021208 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.2e-29 550538021209 the sequence has been checked and is believed to be correct 550538021210 hypothetical protein; Provisional; Region: PRK12378 550538021211 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 6e-124 550538021212 Methyltransferase domain; Region: Methyltransf_23; pfam13489 550538021213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538021214 S-adenosylmethionine binding site [chemical binding]; other site 550538021215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538021216 S-adenosylmethionine binding site [chemical binding]; other site 550538021217 HMMPfam hit to PF08242, Methyltransferase type 12, score 1.7e-10 550538021218 HMMPfam hit to PF08241, Methyltransferase type 11, score 8.1e-21 550538021219 hypothetical protein; Provisional; Region: PRK13687 550538021220 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 550538021221 HMMPfam hit to PF06353, Protein of unknown function DUF1062, score 8.6e-116 550538021222 the sequence has been checked and is believed to be correct 550538021223 the sequence has been checked and is believed to be correct 550538021224 HMMPfam hit to PF03625, Protein of unknown function DUF302, score 9e-20 550538021225 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 550538021226 HMMPfam hit to PF01738, Dienelactone hydrolase, score 3.1e-06 550538021227 PS00120 Lipases, serine active site. 550538021228 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 550538021229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 550538021230 DNA-binding site [nucleotide binding]; DNA binding site 550538021231 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 550538021232 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 9.2e-31 550538021233 PS00043 Bacterial regulatory proteins, gntR family signature. 550538021234 HMMPfam hit to PF07729, GntR, C-terminal, score 6.8e-38 550538021235 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 550538021236 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 550538021237 active site 550538021238 HIGH motif; other site 550538021239 dimer interface [polypeptide binding]; other site 550538021240 KMSKS motif; other site 550538021241 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 4.6e-69 550538021242 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 550538021243 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 550538021244 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 1.3e-51 550538021245 aspartate racemase; Region: asp_race; TIGR00035 550538021246 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 550538021247 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 3.7e-23 550538021248 PS00923 Aspartate and glutamate racemases signature 1. 550538021249 PS00924 Aspartate and glutamate racemases signature 2. 550538021250 cell density-dependent motility repressor; Provisional; Region: PRK10082 550538021251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 550538021252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 550538021253 dimerization interface [polypeptide binding]; other site 550538021254 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-23 550538021255 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.9e-13 550538021256 PS00044 Bacterial regulatory proteins, lysR family signature. 550538021257 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 550538021258 isoaspartyl dipeptidase; Provisional; Region: PRK10657 550538021259 dimer interface [polypeptide binding]; other site 550538021260 active site 550538021261 HMMPfam hit to PF01979, Amidohydrolase 1, score 6.1e-06 550538021262 hypothetical protein; Provisional; Region: PRK10519 550538021263 3 probable transmembrane helices predicted for SG4343 by TMHMM2.0 at aa 20-42, 68-90 and 130-152 550538021264 HMMPfam hit to PF07670, Nucleoside recognition, score 1e-14 550538021265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 550538021266 Nucleoside recognition; Region: Gate; pfam07670 550538021267 HMMPfam hit to PF07670, Nucleoside recognition, score 8e-15 550538021268 5 probable transmembrane helices predicted for SG4344 by TMHMM2.0 at aa 17-39, 72-94, 126-145, 160-182 and 226-248 550538021269 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 550538021270 12 probable transmembrane helices predicted for SG4345 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130, 137-159, 169-191, 212-234, 244-266, 271-293, 297-319, 331-353 and 358-380 550538021271 HMMPfam hit to PF06779, Protein of unknown function DUF1228, score 1.3e-49 550538021272 Predicted membrane protein [Function unknown]; Region: COG2733 550538021273 3 probable transmembrane helices predicted for SG4346 by TMHMM2.0 at aa 13-32, 42-62 and 398-420 550538021274 HMMPfam hit to PF04286, Protein of unknown function DUF445, transmembrane, score 5.9e-153 550538021275 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 550538021276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 550538021277 putative substrate translocation pore; other site 550538021278 12 probable transmembrane helices predicted for SG4347 by TMHMM2.0 at aa 13-35, 50-72, 84-103, 107-129, 141-163, 167-189, 219-241, 256-278, 290-312, 316-338, 350-372 and 376-398 550538021279 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5e-30 550538021280 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 550538021281 PS00216 Sugar transport proteins signature 1. 550538021282 hypothetical protein; Provisional; Region: PRK09956 550538021283 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 550538021284 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 5e-196 550538021286 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 5.4e-26 550538021287 Imigration control region; ROD40 550538021289 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N terminus, score 1.8e-58 550538021290 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 550538021291 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 1.5e-17 550538021292 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 2.6e-29 550538021293 HsdM N-terminal domain; Region: HsdM_N; pfam12161 550538021294 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 550538021295 Methyltransferase domain; Region: Methyltransf_26; pfam13659 550538021296 HMMPfam hit to PF02384, N-6 DNA methylase, score 2.9e-200 550538021297 PS00092 N-6 Adenine-specific DNA methylases signature. 550538021298 the sequence has been checked and is believed to be correct 550538021299 HMMPfam hit to PF02384, N-6 DNA methylase, score 1.2e-38 550538021300 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 550538021301 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 2.8e-06 550538021302 PS00435 Peroxidases proximal heme-ligand signature. 550538021303 Nuclease-related domain; Region: NERD; pfam08378 550538021304 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 550538021305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 550538021306 Family description; Region: UvrD_C_2; pfam13538 550538021307 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 550538021309 HMMPfam hit to PF04365, Protein of unknown function DUF497, score 5.8e-20 550538021310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 550538021311 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 550538021312 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 550538021313 P-loop, Walker A motif; other site 550538021314 Base recognition motif; other site 550538021315 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 550538021316 HMMPfam hit to PF07683, Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal, score 1.6e-34 550538021317 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 4.1e-76 550538021318 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021319 Uncharacterized small protein [Function unknown]; Region: COG2879 550538021320 HMMPfam hit to PF04328, Protein of unknown function DUF466, score 1.6e-46 550538021321 carbon starvation protein A; Provisional; Region: PRK15015 550538021322 Carbon starvation protein CstA; Region: CstA; pfam02554 550538021323 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 550538021324 16 probable transmembrane helices predicted for SG4362 by TMHMM2.0 at aa 12-29, 34-56, 89-111, 121-140, 161-183, 193-215, 220-242, 257-279, 286-305, 325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 662-684 550538021325 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 3.7e-287 550538021326 methyl-accepting protein IV; Provisional; Region: PRK09793 550538021327 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 550538021328 dimer interface [polypeptide binding]; other site 550538021329 ligand binding site [chemical binding]; other site 550538021330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 550538021331 dimerization interface [polypeptide binding]; other site 550538021332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 550538021333 dimer interface [polypeptide binding]; other site 550538021334 putative CheW interface [polypeptide binding]; other site 550538021335 2 probable transmembrane helices predicted for SG4363 by TMHMM2.0 at aa 7-29 and 192-214 550538021336 HMMPfam hit to PF02203, Ligand binding Tar, score 1.2e-56 550538021337 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.8e-16 550538021338 PS00538 Bacterial chemotaxis sensory transducers signature. 550538021339 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 4.6e-122 550538021340 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 550538021341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538021342 Walker A motif; other site 550538021343 ATP binding site [chemical binding]; other site 550538021344 Walker B motif; other site 550538021345 arginine finger; other site 550538021346 Transcriptional antiterminator [Transcription]; Region: COG3933 550538021347 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 550538021348 active pocket/dimerization site; other site 550538021349 active site 550538021350 phosphorylation site [posttranslational modification] 550538021351 PRD domain; Region: PRD; pfam00874 550538021352 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 6e-65 550538021353 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 550538021354 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021355 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 550538021356 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 550538021357 HMMPfam hit to PF00874, PRD, score 7.5e-16 550538021358 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 550538021359 active pocket/dimerization site; other site 550538021360 active site 550538021361 phosphorylation site [posttranslational modification] 550538021362 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 8.6e-08 550538021363 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 550538021364 active site 550538021365 phosphorylation site [posttranslational modification] 550538021366 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 1.6e-44 550538021367 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 550538021368 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 1.3e-53 550538021369 7 probable transmembrane helices predicted for SG4367 by TMHMM2.0 at aa 7-29, 44-63, 70-92, 96-118, 138-160, 180-199 and 206-237 550538021370 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 550538021371 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 7e-115 550538021372 6 probable transmembrane helices predicted for SG4368 by TMHMM2.0 at aa 69-91, 111-133, 146-168, 197-219, 231-253 and 258-277 550538021373 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 550538021374 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 550538021375 dimer interface [polypeptide binding]; other site 550538021376 active site 550538021377 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 550538021378 dimer interface [polypeptide binding]; other site 550538021379 active site 550538021380 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 9.9e-10 550538021381 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021382 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.013 550538021383 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 550538021384 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 550538021385 putative active site [active] 550538021386 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 550538021387 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.5e-11 550538021388 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.013 550538021389 phosphoglycerol transferase I; Provisional; Region: PRK03776 550538021390 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 550538021391 HMMPfam hit to PF00884, Sulphatase, score 1.8e-20 550538021392 2 probable transmembrane helices predicted for SG4371 by TMHMM2.0 at aa 43-65 and 77-99 550538021393 hypothetical protein; Provisional; Region: PRK11667 550538021394 1 probable transmembrane helix predicted for SG4372 by TMHMM2.0 at aa 7-29 550538021395 DNA replication protein DnaC; Validated; Region: PRK07952 550538021396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 550538021397 Walker A motif; other site 550538021398 ATP binding site [chemical binding]; other site 550538021399 Walker B motif; other site 550538021400 primosomal protein DnaI; Provisional; Region: PRK02854 550538021401 hypothetical protein; Provisional; Region: PRK09917 550538021402 4 probable transmembrane helices predicted for SG4375 by TMHMM2.0 at aa 7-29, 53-75, 87-109 and 129-151 550538021403 Uncharacterized conserved protein [Function unknown]; Region: COG2966 550538021404 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 550538021405 4 probable transmembrane helices predicted for SG4376 by TMHMM2.0 at aa 184-201, 214-236, 241-263 and 276-298 550538021406 HMMPfam hit to PF06738, Protein of unknown function DUF1212, score 9.3e-75 550538021407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 550538021408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538021409 DNA binding residues [nucleotide binding] 550538021410 dimerization interface [polypeptide binding]; other site 550538021411 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.3e-07 550538021412 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 550538021413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 550538021414 DNA binding residues [nucleotide binding] 550538021415 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 6.5e-15 550538021416 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 550538021417 putative deacylase active site [active] 550538021418 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 2.3e-44 550538021419 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 550538021420 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 550538021421 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 550538021422 HMMPfam hit to PF06276, Ferric iron reductase, score 6.5e-147 550538021423 PS00294 Prenyl group binding site (CAAX box). 550538021424 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 550538021425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 550538021426 metal binding site [ion binding]; metal-binding site 550538021427 active site 550538021428 I-site; other site 550538021429 HMMPfam hit to PF00990, GGDEF, score 1.1e-62 550538021430 5 probable transmembrane helices predicted for SG4381 by TMHMM2.0 at aa 21-40, 45-62, 69-86, 101-123 and 144-163 550538021431 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 550538021432 HMMPfam hit to PF07256, Protein of unknown function DUF1435, score 2.9e-55 550538021433 3 probable transmembrane helices predicted for SG4382 by TMHMM2.0 at aa 5-27, 31-48 and 55-72 550538021434 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 550538021435 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 550538021436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 550538021437 S-adenosylmethionine binding site [chemical binding]; other site 550538021438 HMMPfam hit to PF05175, Methyltransferase small, score 7.5e-100 550538021439 PS00092 N-6 Adenine-specific DNA methylases signature. 550538021440 HMMPfam hit to PF08468, Methyltransferase small, N-terminal, score 2.2e-91 550538021441 DNA polymerase III subunit psi; Validated; Region: PRK06856 550538021442 HMMPfam hit to PF03603, DNA polymerase III, psi subunit, score 1.4e-52 550538021443 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 550538021444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 550538021445 Coenzyme A binding pocket [chemical binding]; other site 550538021446 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.4e-22 550538021447 dUMP phosphatase; Provisional; Region: PRK09449 550538021448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538021449 motif II; other site 550538021450 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 3.1e-30 550538021451 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 550538021452 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 550538021453 G1 box; other site 550538021454 putative GEF interaction site [polypeptide binding]; other site 550538021455 GTP/Mg2+ binding site [chemical binding]; other site 550538021456 Switch I region; other site 550538021457 G2 box; other site 550538021458 G3 box; other site 550538021459 Switch II region; other site 550538021460 G4 box; other site 550538021461 G5 box; other site 550538021462 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 550538021463 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 6.2e-60 550538021464 PS00301 GTP-binding elongation factors signature. 550538021465 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3e-12 550538021466 periplasmic protein; Provisional; Region: PRK10568 550538021467 BON domain; Region: BON; pfam04972 550538021468 HMMPfam hit to PF04972, Transport-associated, score 1e-15 550538021469 HMMPfam hit to PF04972, Transport-associated, score 1.2e-14 550538021470 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 550538021471 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 550538021472 active site 550538021473 nucleophile elbow; other site 550538021474 HMMPfam hit to PF01734, Patatin, score 1.2e-22 550538021475 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 550538021476 active site 550538021477 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 2e-101 550538021478 PS01137 Uncharacterized protein family UPF0006 signature 1. 550538021479 PS01090 Uncharacterized protein family UPF0006 signature 2. 550538021480 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 550538021481 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 550538021482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 550538021483 FeS/SAM binding site; other site 550538021484 HMMPfam hit to PF04055, Radical SAM, score 9.6e-09 550538021485 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0036 550538021486 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538021487 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.2e-05 550538021488 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 550538021489 PS01087 Radical activating enzymes signature. 550538021490 PS00190 Cytochrome c family heme-binding site signature. 550538021491 hypothetical protein; Provisional; Region: PRK10977 550538021492 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 550538021493 intersubunit interface [polypeptide binding]; other site 550538021494 active site 550538021495 catalytic residue [active] 550538021496 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 1.7e-83 550538021497 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 550538021498 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 550538021499 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 550538021500 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 550538021501 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 4.3e-26 550538021502 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 5.4e-85 550538021503 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 550538021504 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase, C-terminal, score 4.5e-31 550538021505 phosphopentomutase; Provisional; Region: PRK05362 550538021506 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 550538021507 HMMPfam hit to PF08342, Phosphopentomutase N-terminal, score 5.9e-68 550538021508 HMMPfam hit to PF01676, Metalloenzyme, score 5.4e-48 550538021509 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 550538021510 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 550538021511 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 9.6e-113 550538021512 PS01232 Purine and other phosphorylases family 1 signature. 550538021513 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 550538021514 the sequence has been checked and is believed to be correct 550538021515 HMMPfam hit to PF07805, HipA-like, N-terminal, score 5.1e-11 550538021516 HMMPfam hit to PF07804, HipA-like, C-terminal, score 4e-05 550538021517 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 550538021518 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 550538021519 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 550538021520 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 1.3e-18 550538021521 hypothetical protein; Provisional; Region: PRK11246 550538021522 2 probable transmembrane helices predicted for SG4399 by TMHMM2.0 at aa 13-32 and 162-184 550538021523 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 550538021524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 550538021525 motif II; other site 550538021526 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 3.9e-26 550538021527 DNA repair protein RadA; Region: sms; TIGR00416 550538021528 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 550538021529 Walker A motif/ATP binding site; other site 550538021530 ATP binding site [chemical binding]; other site 550538021531 Walker B motif; other site 550538021532 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 550538021533 PS00190 Cytochrome c family heme-binding site signature. 550538021534 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 550538021536 non-specific DNA binding site [nucleotide binding]; other site 550538021537 salt bridge; other site 550538021538 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 550538021539 sequence-specific DNA binding site [nucleotide binding]; other site 550538021540 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 550538021541 active site 550538021542 (T/H)XGH motif; other site 550538021543 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 550538021544 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 4.5e-10 550538021545 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021546 PS00687 Aldehyde dehydrogenases glutamic acid active site. 550538021547 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 550538021548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538021549 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538021550 ABC transporter; Region: ABC_tran_2; pfam12848 550538021551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 550538021552 HMMPfam hit to PF00005, ABC transporter related, score 7.7e-56 550538021553 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021554 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-62 550538021555 PS00211 ABC transporters family signature. 550538021556 PS00017 ATP/GTP-binding site motif A (P-loop). 550538021557 lytic murein transglycosylase; Provisional; Region: PRK11619 550538021558 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 550538021559 N-acetyl-D-glucosamine binding site [chemical binding]; other site 550538021560 catalytic residue [active] 550538021561 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1.6e-44 550538021562 PS00922 Prokaryotic transglycosylases signature. 550538021563 Trp operon repressor; Provisional; Region: PRK01381 550538021564 HMMPfam hit to PF01371, Trp repressor, score 3.7e-41 550538021565 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 550538021566 HMMPfam hit to PF01931, Protein of unknown function DUF84, score 3.9e-108 550538021567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 550538021568 catalytic core [active] 550538021569 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 7.1e-50 550538021570 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 550538021571 1 probable transmembrane helix predicted for SG4407 by TMHMM2.0 at aa 146-168 550538021572 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 550538021573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 550538021574 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 550538021575 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 4.8e-23 550538021576 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.8e-09 550538021577 PS00041 Bacterial regulatory proteins, araC family signature. 550538021578 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.5e-11 550538021579 hypothetical protein; Provisional; Region: PRK10756 550538021580 CreA protein; Region: CreA; pfam05981 550538021581 HMMPfam hit to PF05981, CreA, score 2.8e-95 550538021582 DNA-binding response regulator CreB; Provisional; Region: PRK11083 550538021583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538021584 active site 550538021585 phosphorylation site [posttranslational modification] 550538021586 intermolecular recognition site; other site 550538021587 dimerization interface [polypeptide binding]; other site 550538021588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538021589 DNA binding site [nucleotide binding] 550538021590 HMMPfam hit to PF00072, Response regulator receiver, score 1.7e-25 550538021591 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2.5e-20 550538021592 sensory histidine kinase CreC; Provisional; Region: PRK11100 550538021593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 550538021594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 550538021595 dimer interface [polypeptide binding]; other site 550538021596 phosphorylation site [posttranslational modification] 550538021597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 550538021598 ATP binding site [chemical binding]; other site 550538021599 Mg2+ binding site [ion binding]; other site 550538021600 G-X-G motif; other site 550538021601 2 probable transmembrane helices predicted for SG4411 by TMHMM2.0 at aa 5-27 and 184-206 550538021602 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.8e-10 550538021603 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.3e-15 550538021604 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.4e-31 550538021605 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 550538021606 PS00430 TonB-dependent receptor proteins signature 1. 550538021607 HMMPfam hit to PF06123, Inner membrane CreD, score 5.1e-270 550538021608 6 probable transmembrane helices predicted for SG4412 by TMHMM2.0 at aa 10-32, 298-317, 321-343, 350-372, 377-396 and 403-420 550538021609 fimbrial operon sth 550538021610 the sequence has been checked and is believed to be correct 550538021611 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 3.6e-05 550538021612 putative fimbrial protein SthD; Provisional; Region: PRK15293 550538021613 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.1e-11 550538021614 1 probable transmembrane helix predicted for SG4414 by TMHMM2.0 at aa 7-29 550538021615 the sequence has been checked and is believed to be correct 550538021616 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 550538021617 the sequence has been checked and is believed to be correct 550538021618 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 8.7e-14 550538021619 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 8.7e-45 550538021620 putative fimbrial protein SthA; Provisional; Region: PRK15296 550538021621 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 3.1e-20 550538021622 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 550538021623 Helix-turn-helix domain; Region: HTH_36; pfam13730 550538021624 1 probable transmembrane helix predicted for SG4419 by TMHMM2.0 at aa 7-29 550538021625 two-component response regulator; Provisional; Region: PRK11173 550538021626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 550538021627 active site 550538021628 phosphorylation site [posttranslational modification] 550538021629 intermolecular recognition site; other site 550538021630 dimerization interface [polypeptide binding]; other site 550538021631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 550538021632 DNA binding site [nucleotide binding] 550538021633 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3.6e-18 550538021634 HMMPfam hit to PF00072, Response regulator receiver, score 1.8e-36 550538021635 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 550538021636 putative RNA methyltransferase; Provisional; Region: PRK10433 550538021637 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 4.2e-36