-- dump date   	20140620_051637
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1225522000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1225522000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1225522000003	putative catalytic residues [active]
1225522000004	putative nucleotide binding site [chemical binding]; other site
1225522000005	putative aspartate binding site [chemical binding]; other site
1225522000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1225522000007	dimer interface [polypeptide binding]; other site
1225522000008	putative threonine allosteric regulatory site; other site
1225522000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
1225522000010	putative threonine allosteric regulatory site; other site
1225522000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1225522000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1225522000013	homoserine kinase; Provisional; Region: PRK01212
1225522000014	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1225522000015	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1225522000016	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1225522000017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522000018	catalytic residue [active]
1225522000019	hypothetical protein; Validated; Region: PRK02101
1225522000020	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1225522000021	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1225522000022	transaldolase-like protein; Provisional; Region: PTZ00411
1225522000023	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1225522000024	active site
1225522000025	dimer interface [polypeptide binding]; other site
1225522000026	catalytic residue [active]
1225522000027	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1225522000028	MPT binding site; other site
1225522000029	trimer interface [polypeptide binding]; other site
1225522000030	hypothetical protein; Provisional; Region: PRK10659
1225522000031	hypothetical protein; Provisional; Region: PRK10236
1225522000032	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
1225522000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1225522000034	Protein of unknown function (DUF2541); Region: DUF2541; cl08090
1225522000035	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1225522000036	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1225522000037	nucleotide binding site [chemical binding]; other site
1225522000038	chaperone protein DnaJ; Provisional; Region: PRK10767
1225522000039	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1225522000040	HSP70 interaction site [polypeptide binding]; other site
1225522000041	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1225522000042	substrate binding site [polypeptide binding]; other site
1225522000043	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1225522000044	Zn binding sites [ion binding]; other site
1225522000045	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1225522000046	dimer interface [polypeptide binding]; other site
1225522000047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522000048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000049	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1225522000050	substrate binding pocket [chemical binding]; other site
1225522000051	dimerization interface [polypeptide binding]; other site
1225522000052	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
1225522000053	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1225522000054	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1225522000055	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1225522000056	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
1225522000057	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1225522000058	active site
1225522000059	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1225522000060	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1225522000061	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1225522000062	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1225522000063	Helix-turn-helix domain; Region: HTH_36; pfam13730
1225522000064	fimbrial protein BcfA; Provisional; Region: PRK15187
1225522000065	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
1225522000066	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522000067	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522000068	outer membrane usher protein; Provisional; Region: PRK15193
1225522000069	PapC N-terminal domain; Region: PapC_N; pfam13954
1225522000070	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1225522000071	PapC C-terminal domain; Region: PapC_C; pfam13953
1225522000072	fimbrial protein BcfD; Provisional; Region: PRK15189
1225522000073	Fimbrial protein; Region: Fimbrial; cl01416
1225522000074	fimbrial protein BcfF; Provisional; Region: PRK15191
1225522000075	fimbrial chaperone BcfG; Provisional; Region: PRK15192
1225522000076	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522000077	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522000078	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1225522000079	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1225522000080	catalytic residues [active]
1225522000081	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1225522000082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522000083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000084	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522000085	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1225522000086	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
1225522000087	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1225522000088	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1225522000089	active site
1225522000090	metal binding site [ion binding]; metal-binding site
1225522000091	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1225522000092	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
1225522000093	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1225522000094	Sulfatase; Region: Sulfatase; pfam00884
1225522000095	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1225522000096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522000097	FeS/SAM binding site; other site
1225522000098	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1225522000099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1225522000100	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
1225522000101	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1225522000102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000103	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1225522000104	putative dimerization interface [polypeptide binding]; other site
1225522000105	putative alpha-glucosidase; Provisional; Region: PRK10658
1225522000106	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1225522000107	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
1225522000108	putative active site [active]
1225522000109	putative catalytic site [active]
1225522000110	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1225522000111	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
1225522000112	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1225522000113	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1225522000114	active site
1225522000115	Riboflavin kinase; Region: Flavokinase; smart00904
1225522000116	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1225522000117	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1225522000118	active site
1225522000119	HIGH motif; other site
1225522000120	nucleotide binding site [chemical binding]; other site
1225522000121	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1225522000122	active site
1225522000123	KMSKS motif; other site
1225522000124	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1225522000125	tRNA binding surface [nucleotide binding]; other site
1225522000126	anticodon binding site; other site
1225522000127	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1225522000128	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1225522000129	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1225522000130	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1225522000131	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1225522000132	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1225522000133	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1225522000134	active site
1225522000135	tetramer interface [polypeptide binding]; other site
1225522000136	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1225522000137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522000138	active site
1225522000139	phosphorylation site [posttranslational modification]
1225522000140	intermolecular recognition site; other site
1225522000141	dimerization interface [polypeptide binding]; other site
1225522000142	Transcriptional regulator; Region: CitT; pfam12431
1225522000143	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1225522000144	PAS domain; Region: PAS; smart00091
1225522000145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522000146	ATP binding site [chemical binding]; other site
1225522000147	Mg2+ binding site [ion binding]; other site
1225522000148	G-X-G motif; other site
1225522000149	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
1225522000150	oxaloacetate decarboxylase; Provisional; Region: PRK14040
1225522000151	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1225522000152	active site
1225522000153	catalytic residues [active]
1225522000154	metal binding site [ion binding]; metal-binding site
1225522000155	homodimer binding site [polypeptide binding]; other site
1225522000156	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1225522000157	carboxyltransferase (CT) interaction site; other site
1225522000158	biotinylation site [posttranslational modification]; other site
1225522000159	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
1225522000160	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1225522000161	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
1225522000162	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1225522000163	putative active site [active]
1225522000164	(T/H)XGH motif; other site
1225522000165	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
1225522000166	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1225522000167	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1225522000168	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
1225522000169	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
1225522000170	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1225522000171	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1225522000172	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1225522000173	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1225522000174	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1225522000175	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1225522000176	catalytic site [active]
1225522000177	subunit interface [polypeptide binding]; other site
1225522000178	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1225522000179	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1225522000180	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1225522000181	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1225522000182	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1225522000183	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1225522000184	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1225522000185	IMP binding site; other site
1225522000186	dimer interface [polypeptide binding]; other site
1225522000187	interdomain contacts; other site
1225522000188	partial ornithine binding site; other site
1225522000189	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
1225522000190	carnitine operon protein CaiE; Provisional; Region: PRK13627
1225522000191	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
1225522000192	putative trimer interface [polypeptide binding]; other site
1225522000193	putative metal binding site [ion binding]; other site
1225522000194	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
1225522000195	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1225522000196	substrate binding site [chemical binding]; other site
1225522000197	oxyanion hole (OAH) forming residues; other site
1225522000198	trimer interface [polypeptide binding]; other site
1225522000199	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
1225522000200	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
1225522000201	acyl-activating enzyme (AAE) consensus motif; other site
1225522000202	putative AMP binding site [chemical binding]; other site
1225522000203	putative active site [active]
1225522000204	putative CoA binding site [chemical binding]; other site
1225522000205	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
1225522000206	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1225522000207	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
1225522000208	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1225522000209	active site
1225522000210	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
1225522000211	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1225522000212	Ligand binding site [chemical binding]; other site
1225522000213	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1225522000214	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
1225522000215	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
1225522000216	Ligand binding site [chemical binding]; other site
1225522000217	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1225522000218	putative oxidoreductase FixC; Provisional; Region: PRK10157
1225522000219	ferredoxin-like protein FixX; Provisional; Region: PRK15449
1225522000220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522000221	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1225522000222	putative substrate translocation pore; other site
1225522000223	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1225522000224	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522000225	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
1225522000226	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1225522000227	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1225522000228	TrkA-N domain; Region: TrkA_N; pfam02254
1225522000229	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1225522000230	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1225522000231	folate binding site [chemical binding]; other site
1225522000232	NADP+ binding site [chemical binding]; other site
1225522000233	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
1225522000234	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1225522000235	active site
1225522000236	metal binding site [ion binding]; metal-binding site
1225522000237	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1225522000238	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1225522000239	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1225522000240	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1225522000241	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1225522000242	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1225522000243	SurA N-terminal domain; Region: SurA_N; pfam09312
1225522000244	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1225522000245	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1225522000246	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
1225522000247	OstA-like protein; Region: OstA; pfam03968
1225522000248	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1225522000249	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1225522000250	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1225522000251	putative metal binding site [ion binding]; other site
1225522000252	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1225522000253	HSP70 interaction site [polypeptide binding]; other site
1225522000254	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1225522000255	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1225522000256	active site
1225522000257	ATP-dependent helicase HepA; Validated; Region: PRK04914
1225522000258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522000259	ATP binding site [chemical binding]; other site
1225522000260	putative Mg++ binding site [ion binding]; other site
1225522000261	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522000262	nucleotide binding region [chemical binding]; other site
1225522000263	ATP-binding site [chemical binding]; other site
1225522000264	DNA polymerase II; Reviewed; Region: PRK05762
1225522000265	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1225522000266	active site
1225522000267	catalytic site [active]
1225522000268	substrate binding site [chemical binding]; other site
1225522000269	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1225522000270	active site
1225522000271	metal-binding site
1225522000272	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1225522000273	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1225522000274	putative active site [active]
1225522000275	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1225522000276	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1225522000277	intersubunit interface [polypeptide binding]; other site
1225522000278	active site
1225522000279	Zn2+ binding site [ion binding]; other site
1225522000280	L-arabinose isomerase; Provisional; Region: PRK02929
1225522000281	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1225522000282	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1225522000283	trimer interface [polypeptide binding]; other site
1225522000284	putative substrate binding site [chemical binding]; other site
1225522000285	putative metal binding site [ion binding]; other site
1225522000286	ribulokinase; Provisional; Region: PRK04123
1225522000287	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1225522000288	N- and C-terminal domain interface [polypeptide binding]; other site
1225522000289	active site
1225522000290	MgATP binding site [chemical binding]; other site
1225522000291	catalytic site [active]
1225522000292	metal binding site [ion binding]; metal-binding site
1225522000293	carbohydrate binding site [chemical binding]; other site
1225522000294	homodimer interface [polypeptide binding]; other site
1225522000295	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
1225522000296	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1225522000297	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522000298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522000299	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1225522000300	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1225522000301	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
1225522000302	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
1225522000303	Walker A/P-loop; other site
1225522000304	ATP binding site [chemical binding]; other site
1225522000305	Q-loop/lid; other site
1225522000306	ABC transporter signature motif; other site
1225522000307	Walker B; other site
1225522000308	D-loop; other site
1225522000309	H-loop/switch region; other site
1225522000310	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1225522000311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522000312	dimer interface [polypeptide binding]; other site
1225522000313	conserved gate region; other site
1225522000314	putative PBP binding loops; other site
1225522000315	ABC-ATPase subunit interface; other site
1225522000316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522000317	dimer interface [polypeptide binding]; other site
1225522000318	conserved gate region; other site
1225522000319	putative PBP binding loops; other site
1225522000320	ABC-ATPase subunit interface; other site
1225522000321	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1225522000322	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1225522000323	transcriptional regulator SgrR; Provisional; Region: PRK13626
1225522000324	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1225522000325	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1225522000326	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1225522000327	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1225522000328	substrate binding site [chemical binding]; other site
1225522000329	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1225522000330	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1225522000331	substrate binding site [chemical binding]; other site
1225522000332	ligand binding site [chemical binding]; other site
1225522000333	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1225522000334	tartrate dehydrogenase; Region: TTC; TIGR02089
1225522000335	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1225522000336	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000337	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
1225522000338	putative substrate binding pocket [chemical binding]; other site
1225522000339	putative dimerization interface [polypeptide binding]; other site
1225522000340	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1225522000341	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1225522000342	putative valine binding site [chemical binding]; other site
1225522000343	dimer interface [polypeptide binding]; other site
1225522000344	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1225522000345	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1225522000346	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522000347	DNA binding site [nucleotide binding]
1225522000348	domain linker motif; other site
1225522000349	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1225522000350	dimerization interface [polypeptide binding]; other site
1225522000351	ligand binding site [chemical binding]; other site
1225522000352	mraZ protein; Region: TIGR00242
1225522000353	MraZ protein; Region: MraZ; pfam02381
1225522000354	MraZ protein; Region: MraZ; pfam02381
1225522000355	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
1225522000356	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1225522000357	cell division protein FtsL; Provisional; Region: PRK10772
1225522000358	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1225522000359	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1225522000360	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1225522000361	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1225522000362	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1225522000363	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1225522000364	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1225522000365	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
1225522000366	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1225522000367	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1225522000368	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1225522000369	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1225522000370	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1225522000371	Mg++ binding site [ion binding]; other site
1225522000372	putative catalytic motif [active]
1225522000373	putative substrate binding site [chemical binding]; other site
1225522000374	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
1225522000375	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1225522000376	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1225522000377	cell division protein FtsW; Provisional; Region: PRK10774
1225522000378	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1225522000379	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1225522000380	active site
1225522000381	homodimer interface [polypeptide binding]; other site
1225522000382	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1225522000383	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1225522000384	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1225522000385	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1225522000386	cell division protein FtsQ; Provisional; Region: PRK10775
1225522000387	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1225522000388	Cell division protein FtsQ; Region: FtsQ; pfam03799
1225522000389	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
1225522000390	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522000391	Cell division protein FtsA; Region: FtsA; pfam14450
1225522000392	cell division protein FtsZ; Validated; Region: PRK09330
1225522000393	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1225522000394	nucleotide binding site [chemical binding]; other site
1225522000395	SulA interaction site; other site
1225522000396	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
1225522000397	UDP-3-0-acyl N-acetylglucosamine deacetylase; Region: lpxC; TIGR00325
1225522000398	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1225522000399	SecA regulator SecM; Provisional; Region: PRK02943
1225522000400	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1225522000401	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1225522000402	SEC-C motif; Region: SEC-C; pfam02810
1225522000403	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1225522000404	active site
1225522000405	8-oxo-dGMP binding site [chemical binding]; other site
1225522000406	nudix motif; other site
1225522000407	metal binding site [ion binding]; metal-binding site
1225522000408	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522000409	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522000410	active site
1225522000411	catalytic tetrad [active]
1225522000412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522000413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000414	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1225522000415	putative dimerization interface [polypeptide binding]; other site
1225522000416	putative effector binding pocket; other site
1225522000417	DNA gyrase inhibitor; Reviewed; Region: PRK00418
1225522000418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
1225522000419	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1225522000420	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1225522000421	CoA-binding site [chemical binding]; other site
1225522000422	ATP-binding [chemical binding]; other site
1225522000423	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
1225522000424	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1225522000425	active site
1225522000426	type IV pilin biogenesis protein; Provisional; Region: PRK10573
1225522000427	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1225522000428	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1225522000429	hypothetical protein; Provisional; Region: PRK10436
1225522000430	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1225522000431	Walker A motif; other site
1225522000432	ATP binding site [chemical binding]; other site
1225522000433	Walker B motif; other site
1225522000434	putative major pilin subunit; Provisional; Region: PRK10574
1225522000435	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1225522000436	Pilin (bacterial filament); Region: Pilin; pfam00114
1225522000437	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1225522000438	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1225522000439	dimerization interface [polypeptide binding]; other site
1225522000440	active site
1225522000441	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1225522000442	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1225522000443	amidase catalytic site [active]
1225522000444	Zn binding residues [ion binding]; other site
1225522000445	substrate binding site [chemical binding]; other site
1225522000446	regulatory protein AmpE; Provisional; Region: PRK10987
1225522000447	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1225522000448	active site
1225522000449	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1225522000450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522000451	putative substrate translocation pore; other site
1225522000452	aromatic amino acid transporter; Provisional; Region: PRK10238
1225522000453	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1225522000454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522000455	DNA-binding site [nucleotide binding]; DNA binding site
1225522000456	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1225522000457	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1225522000458	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1225522000459	dimer interface [polypeptide binding]; other site
1225522000460	TPP-binding site [chemical binding]; other site
1225522000461	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1225522000462	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1225522000463	E3 interaction surface; other site
1225522000464	lipoyl attachment site [posttranslational modification]; other site
1225522000465	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1225522000466	E3 interaction surface; other site
1225522000467	lipoyl attachment site [posttranslational modification]; other site
1225522000468	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1225522000469	E3 interaction surface; other site
1225522000470	lipoyl attachment site [posttranslational modification]; other site
1225522000471	e3 binding domain; Region: E3_binding; pfam02817
1225522000472	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1225522000473	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1225522000474	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1225522000475	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522000476	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1225522000477	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
1225522000478	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1225522000479	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1225522000480	substrate binding site [chemical binding]; other site
1225522000481	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1225522000482	substrate binding site [chemical binding]; other site
1225522000483	ligand binding site [chemical binding]; other site
1225522000484	putative inner membrane protein; Provisional; Region: PRK09823
1225522000485	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1225522000486	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1225522000487	active site
1225522000488	hypothetical protein; Provisional; Region: PRK05248
1225522000489	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
1225522000490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1225522000491	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1225522000492	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
1225522000493	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522000494	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522000495	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522000496	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1225522000497	spermidine synthase; Provisional; Region: PRK00811
1225522000498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522000499	S-adenosylmethionine binding site [chemical binding]; other site
1225522000500	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1225522000501	multicopper oxidase; Provisional; Region: PRK10965
1225522000502	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1225522000503	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1225522000504	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1225522000505	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1225522000506	Trp docking motif [polypeptide binding]; other site
1225522000507	putative active site [active]
1225522000508	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1225522000509	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522000510	active site
1225522000511	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1225522000512	active site clefts [active]
1225522000513	zinc binding site [ion binding]; other site
1225522000514	dimer interface [polypeptide binding]; other site
1225522000515	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1225522000516	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1225522000517	Walker A/P-loop; other site
1225522000518	ATP binding site [chemical binding]; other site
1225522000519	Q-loop/lid; other site
1225522000520	ABC transporter signature motif; other site
1225522000521	Walker B; other site
1225522000522	D-loop; other site
1225522000523	H-loop/switch region; other site
1225522000524	inner membrane transport permease; Provisional; Region: PRK15066
1225522000525	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1225522000526	putative fimbrial protein StiH; Provisional; Region: PRK15297
1225522000527	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522000528	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522000529	fimbrial protein StiA; Provisional; Region: PRK15300
1225522000530	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1225522000531	active pocket/dimerization site; other site
1225522000532	active site
1225522000533	phosphorylation site [posttranslational modification]
1225522000534	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
1225522000535	putative active site [active]
1225522000536	putative metal binding site [ion binding]; other site
1225522000537	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1225522000538	tetramerization interface [polypeptide binding]; other site
1225522000539	active site
1225522000540	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1225522000541	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1225522000542	active site
1225522000543	ATP-binding site [chemical binding]; other site
1225522000544	pantoate-binding site; other site
1225522000545	HXXH motif; other site
1225522000546	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1225522000547	oligomerization interface [polypeptide binding]; other site
1225522000548	active site
1225522000549	metal binding site [ion binding]; metal-binding site
1225522000550	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1225522000551	catalytic center binding site [active]
1225522000552	ATP binding site [chemical binding]; other site
1225522000553	poly(A) polymerase; Region: pcnB; TIGR01942
1225522000554	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1225522000555	active site
1225522000556	NTP binding site [chemical binding]; other site
1225522000557	metal binding triad [ion binding]; metal-binding site
1225522000558	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1225522000559	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1225522000560	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1225522000561	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1225522000562	active site
1225522000563	nucleotide binding site [chemical binding]; other site
1225522000564	HIGH motif; other site
1225522000565	KMSKS motif; other site
1225522000566	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
1225522000567	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1225522000568	2'-5' RNA ligase; Provisional; Region: PRK15124
1225522000569	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1225522000570	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1225522000571	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
1225522000572	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522000573	ATP binding site [chemical binding]; other site
1225522000574	putative Mg++ binding site [ion binding]; other site
1225522000575	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522000576	nucleotide binding region [chemical binding]; other site
1225522000577	ATP-binding site [chemical binding]; other site
1225522000578	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1225522000579	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
1225522000580	Transglycosylase; Region: Transgly; pfam00912
1225522000581	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1225522000582	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1225522000583	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522000584	N-terminal plug; other site
1225522000585	ligand-binding site [chemical binding]; other site
1225522000586	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
1225522000587	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1225522000588	Walker A/P-loop; other site
1225522000589	ATP binding site [chemical binding]; other site
1225522000590	Q-loop/lid; other site
1225522000591	ABC transporter signature motif; other site
1225522000592	Walker B; other site
1225522000593	D-loop; other site
1225522000594	H-loop/switch region; other site
1225522000595	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1225522000596	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1225522000597	siderophore binding site; other site
1225522000598	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1225522000599	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522000600	ABC-ATPase subunit  interface; other site
1225522000601	dimer interface [polypeptide binding]; other site
1225522000602	putative PBP binding regions; other site
1225522000603	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522000604	ABC-ATPase subunit  interface; other site
1225522000605	dimer interface [polypeptide binding]; other site
1225522000606	putative PBP binding regions; other site
1225522000607	putative fimbrial subunit StfA; Provisional; Region: PRK15283
1225522000608	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
1225522000609	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522000610	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522000611	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
1225522000612	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
1225522000613	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1225522000614	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1225522000615	inhibitor-cofactor binding pocket; inhibition site
1225522000616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522000617	catalytic residue [active]
1225522000618	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1225522000619	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1225522000620	Cl- selectivity filter; other site
1225522000621	Cl- binding residues [ion binding]; other site
1225522000622	pore gating glutamate residue; other site
1225522000623	dimer interface [polypeptide binding]; other site
1225522000624	H+/Cl- coupling transport residue; other site
1225522000625	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1225522000626	hypothetical protein; Provisional; Region: PRK10578
1225522000627	UPF0126 domain; Region: UPF0126; pfam03458
1225522000628	UPF0126 domain; Region: UPF0126; pfam03458
1225522000629	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
1225522000630	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1225522000631	cobalamin binding residues [chemical binding]; other site
1225522000632	putative BtuC binding residues; other site
1225522000633	dimer interface [polypeptide binding]; other site
1225522000634	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1225522000635	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1225522000636	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
1225522000637	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1225522000638	Zn2+ binding site [ion binding]; other site
1225522000639	Mg2+ binding site [ion binding]; other site
1225522000640	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1225522000641	serine endoprotease; Provisional; Region: PRK10942
1225522000642	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1225522000643	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1225522000644	protein binding site [polypeptide binding]; other site
1225522000645	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1225522000646	hypothetical protein; Provisional; Region: PRK13677
1225522000647	shikimate transporter; Provisional; Region: PRK09952
1225522000648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522000649	putative substrate translocation pore; other site
1225522000650	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1225522000651	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1225522000652	trimer interface [polypeptide binding]; other site
1225522000653	active site
1225522000654	substrate binding site [chemical binding]; other site
1225522000655	CoA binding site [chemical binding]; other site
1225522000656	PII uridylyl-transferase; Provisional; Region: PRK05007
1225522000657	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1225522000658	metal binding triad; other site
1225522000659	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1225522000660	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1225522000661	Zn2+ binding site [ion binding]; other site
1225522000662	Mg2+ binding site [ion binding]; other site
1225522000663	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1225522000664	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1225522000665	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1225522000666	active site
1225522000667	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1225522000668	rRNA interaction site [nucleotide binding]; other site
1225522000669	S8 interaction site; other site
1225522000670	putative laminin-1 binding site; other site
1225522000671	elongation factor Ts; Provisional; Region: tsf; PRK09377
1225522000672	UBA/TS-N domain; Region: UBA; pfam00627
1225522000673	Elongation factor TS; Region: EF_TS; pfam00889
1225522000674	Elongation factor TS; Region: EF_TS; pfam00889
1225522000675	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1225522000676	putative nucleotide binding site [chemical binding]; other site
1225522000677	uridine monophosphate binding site [chemical binding]; other site
1225522000678	homohexameric interface [polypeptide binding]; other site
1225522000679	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1225522000680	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1225522000681	hinge region; other site
1225522000682	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1225522000683	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1225522000684	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1225522000685	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1225522000686	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1225522000687	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1225522000688	catalytic residue [active]
1225522000689	putative FPP diphosphate  binding site; other site
1225522000690	putative FPP binding hydrophobic cleft; other site
1225522000691	dimer interface [polypeptide binding]; other site
1225522000692	putative IPP diphosphate binding site; other site
1225522000693	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1225522000694	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1225522000695	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1225522000696	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1225522000697	active site
1225522000698	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1225522000699	protein binding site [polypeptide binding]; other site
1225522000700	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1225522000701	protein binding site [polypeptide binding]; other site
1225522000702	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1225522000703	putative substrate binding region [chemical binding]; other site
1225522000704	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1225522000705	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1225522000706	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1225522000707	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1225522000708	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1225522000709	Surface antigen; Region: Bac_surface_Ag; pfam01103
1225522000710	periplasmic chaperone; Provisional; Region: PRK10780
1225522000711	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1225522000712	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1225522000713	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1225522000714	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1225522000715	trimer interface [polypeptide binding]; other site
1225522000716	active site
1225522000717	UDP-GlcNAc binding site [chemical binding]; other site
1225522000718	lipid binding site [chemical binding]; lipid-binding site
1225522000719	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1225522000720	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1225522000721	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1225522000722	active site
1225522000723	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1225522000724	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1225522000725	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1225522000726	RNA/DNA hybrid binding site [nucleotide binding]; other site
1225522000727	active site
1225522000728	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1225522000729	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1225522000730	putative active site [active]
1225522000731	putative PHP Thumb interface [polypeptide binding]; other site
1225522000732	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1225522000733	generic binding surface II; other site
1225522000734	generic binding surface I; other site
1225522000735	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1225522000736	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1225522000737	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1225522000738	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
1225522000739	putative sugar binding site [chemical binding]; other site
1225522000740	catalytic residues [active]
1225522000741	PKD domain; Region: PKD; pfam00801
1225522000742	lysine decarboxylase LdcC; Provisional; Region: PRK15399
1225522000743	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1225522000744	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1225522000745	homodimer interface [polypeptide binding]; other site
1225522000746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522000747	catalytic residue [active]
1225522000748	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1225522000749	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1225522000750	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1225522000751	putative metal binding site [ion binding]; other site
1225522000752	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1225522000753	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1225522000754	Ligand Binding Site [chemical binding]; other site
1225522000755	TilS substrate binding domain; Region: TilS; pfam09179
1225522000756	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1225522000757	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210
1225522000758	hypothetical protein; Provisional; Region: PRK04964
1225522000759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
1225522000760	hypothetical protein; Provisional; Region: PRK09256
1225522000761	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1225522000762	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
1225522000763	NlpE N-terminal domain; Region: NlpE; pfam04170
1225522000764	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1225522000765	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1225522000766	dimer interface [polypeptide binding]; other site
1225522000767	motif 1; other site
1225522000768	active site
1225522000769	motif 2; other site
1225522000770	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1225522000771	putative deacylase active site [active]
1225522000772	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1225522000773	active site
1225522000774	motif 3; other site
1225522000775	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1225522000776	anticodon binding site; other site
1225522000777	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1225522000778	homodimer interaction site [polypeptide binding]; other site
1225522000779	cofactor binding site; other site
1225522000780	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
1225522000781	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1225522000782	lipoprotein, YaeC family; Region: TIGR00363
1225522000783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522000784	dimer interface [polypeptide binding]; other site
1225522000785	conserved gate region; other site
1225522000786	ABC-ATPase subunit interface; other site
1225522000787	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1225522000788	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1225522000789	Walker A/P-loop; other site
1225522000790	ATP binding site [chemical binding]; other site
1225522000791	Q-loop/lid; other site
1225522000792	ABC transporter signature motif; other site
1225522000793	Walker B; other site
1225522000794	D-loop; other site
1225522000795	H-loop/switch region; other site
1225522000796	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1225522000797	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
1225522000798	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522000799	active site
1225522000800	motif I; other site
1225522000801	motif II; other site
1225522000802	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
1225522000803	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1225522000804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522000805	putative substrate translocation pore; other site
1225522000806	lipoprotein; Provisional; Region: PRK10759
1225522000807	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1225522000808	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1225522000809	domain interface [polypeptide binding]; other site
1225522000810	putative active site [active]
1225522000811	catalytic site [active]
1225522000812	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1225522000813	domain interface [polypeptide binding]; other site
1225522000814	putative active site [active]
1225522000815	catalytic site [active]
1225522000816	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1225522000817	CoA binding domain; Region: CoA_binding_2; pfam13380
1225522000818	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1225522000819	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1225522000820	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1225522000821	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522000822	Coenzyme A binding pocket [chemical binding]; other site
1225522000823	Uncharacterized conserved protein [Function unknown]; Region: COG3148
1225522000824	putative methyltransferase; Provisional; Region: PRK10864
1225522000825	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1225522000826	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1225522000827	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1225522000828	ligand binding site [chemical binding]; other site
1225522000829	active site
1225522000830	UGI interface [polypeptide binding]; other site
1225522000831	catalytic site [active]
1225522000832	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1225522000833	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522000834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000835	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1225522000836	dimerization interface [polypeptide binding]; other site
1225522000837	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1225522000838	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1225522000839	ATP binding site [chemical binding]; other site
1225522000840	Mg++ binding site [ion binding]; other site
1225522000841	motif III; other site
1225522000842	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522000843	nucleotide binding region [chemical binding]; other site
1225522000844	ATP-binding site [chemical binding]; other site
1225522000845	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1225522000846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522000847	S-adenosylmethionine binding site [chemical binding]; other site
1225522000848	L-aspartate oxidase; Provisional; Region: PRK09077
1225522000849	L-aspartate oxidase; Provisional; Region: PRK06175
1225522000850	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1225522000851	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1225522000852	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1225522000853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1225522000854	DNA binding residues [nucleotide binding]
1225522000855	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
1225522000856	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1225522000857	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1225522000858	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1225522000859	MucB/RseB family; Region: MucB_RseB; pfam03888
1225522000860	SoxR reducing system protein RseC; Provisional; Region: PRK10862
1225522000861	GTP-binding protein LepA; Provisional; Region: PRK05433
1225522000862	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1225522000863	G1 box; other site
1225522000864	putative GEF interaction site [polypeptide binding]; other site
1225522000865	GTP/Mg2+ binding site [chemical binding]; other site
1225522000866	Switch I region; other site
1225522000867	G2 box; other site
1225522000868	G3 box; other site
1225522000869	Switch II region; other site
1225522000870	G4 box; other site
1225522000871	G5 box; other site
1225522000872	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1225522000873	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1225522000874	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1225522000875	signal peptidase I; Provisional; Region: PRK10861
1225522000876	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1225522000877	Catalytic site [active]
1225522000878	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1225522000879	ribonuclease III; Reviewed; Region: rnc; PRK00102
1225522000880	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1225522000881	dimerization interface [polypeptide binding]; other site
1225522000882	active site
1225522000883	metal binding site [ion binding]; metal-binding site
1225522000884	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1225522000885	dsRNA binding site [nucleotide binding]; other site
1225522000886	GTPase Era; Reviewed; Region: era; PRK00089
1225522000887	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1225522000888	G1 box; other site
1225522000889	GTP/Mg2+ binding site [chemical binding]; other site
1225522000890	Switch I region; other site
1225522000891	G2 box; other site
1225522000892	Switch II region; other site
1225522000893	G3 box; other site
1225522000894	G4 box; other site
1225522000895	G5 box; other site
1225522000896	KH domain; Region: KH_2; pfam07650
1225522000897	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1225522000898	Recombination protein O N terminal; Region: RecO_N; pfam11967
1225522000899	Recombination protein O C terminal; Region: RecO_C; pfam02565
1225522000900	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1225522000901	active site
1225522000902	hydrophilic channel; other site
1225522000903	dimerization interface [polypeptide binding]; other site
1225522000904	catalytic residues [active]
1225522000905	active site lid [active]
1225522000906	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1225522000907	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1225522000908	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522000909	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522000910	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1225522000911	dimerization interface [polypeptide binding]; other site
1225522000912	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1225522000913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522000914	putative substrate translocation pore; other site
1225522000915	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1225522000916	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1225522000917	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1225522000918	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1225522000919	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1225522000920	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1225522000921	putative active site [active]
1225522000922	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1225522000923	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1225522000924	putative active site [active]
1225522000925	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1225522000926	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1225522000927	active site turn [active]
1225522000928	phosphorylation site [posttranslational modification]
1225522000929	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1225522000930	hypothetical protein; Provisional; Region: PRK11590
1225522000931	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1225522000932	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1225522000933	nucleoside/Zn binding site; other site
1225522000934	dimer interface [polypeptide binding]; other site
1225522000935	catalytic motif [active]
1225522000936	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1225522000937	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522000938	substrate binding pocket [chemical binding]; other site
1225522000939	membrane-bound complex binding site; other site
1225522000940	hinge residues; other site
1225522000941	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1225522000942	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1225522000943	catalytic residue [active]
1225522000944	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1225522000945	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1225522000946	dimerization interface [polypeptide binding]; other site
1225522000947	ATP binding site [chemical binding]; other site
1225522000948	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
1225522000949	dimerization interface [polypeptide binding]; other site
1225522000950	ATP binding site [chemical binding]; other site
1225522000951	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1225522000952	putative active site [active]
1225522000953	catalytic triad [active]
1225522000954	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1225522000955	HAMP domain; Region: HAMP; pfam00672
1225522000956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522000957	dimer interface [polypeptide binding]; other site
1225522000958	phosphorylation site [posttranslational modification]
1225522000959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522000960	ATP binding site [chemical binding]; other site
1225522000961	Mg2+ binding site [ion binding]; other site
1225522000962	G-X-G motif; other site
1225522000963	hypothetical protein; Provisional; Region: PRK10722
1225522000964	response regulator GlrR; Provisional; Region: PRK15115
1225522000965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522000966	active site
1225522000967	phosphorylation site [posttranslational modification]
1225522000968	intermolecular recognition site; other site
1225522000969	dimerization interface [polypeptide binding]; other site
1225522000970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522000971	Walker A motif; other site
1225522000972	ATP binding site [chemical binding]; other site
1225522000973	Walker B motif; other site
1225522000974	arginine finger; other site
1225522000975	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
1225522000976	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1225522000977	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1225522000978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522000979	putative substrate translocation pore; other site
1225522000980	POT family; Region: PTR2; pfam00854
1225522000981	lysine decarboxylase CadA; Provisional; Region: PRK15400
1225522000982	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1225522000983	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1225522000984	homodimer interface [polypeptide binding]; other site
1225522000985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522000986	catalytic residue [active]
1225522000987	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1225522000988	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
1225522000989	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
1225522000990	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522000991	DNA binding site [nucleotide binding]
1225522000992	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1225522000993	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1225522000994	heme-binding site [chemical binding]; other site
1225522000995	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1225522000996	FAD binding pocket [chemical binding]; other site
1225522000997	FAD binding motif [chemical binding]; other site
1225522000998	phosphate binding motif [ion binding]; other site
1225522000999	beta-alpha-beta structure motif; other site
1225522001000	NAD binding pocket [chemical binding]; other site
1225522001001	Heme binding  pocket [chemical binding]; other site
1225522001002	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1225522001003	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1225522001004	dimer interface [polypeptide binding]; other site
1225522001005	active site
1225522001006	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1225522001007	folate binding site [chemical binding]; other site
1225522001008	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1225522001009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522001010	putative substrate translocation pore; other site
1225522001011	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
1225522001012	PRD domain; Region: PRD; pfam00874
1225522001013	PRD domain; Region: PRD; pfam00874
1225522001014	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
1225522001015	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1225522001016	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
1225522001017	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1225522001018	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1225522001019	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
1225522001020	FAD binding pocket [chemical binding]; other site
1225522001021	FAD binding motif [chemical binding]; other site
1225522001022	phosphate binding motif [ion binding]; other site
1225522001023	beta-alpha-beta structure motif; other site
1225522001024	NAD binding pocket [chemical binding]; other site
1225522001025	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1225522001026	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1225522001027	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1225522001028	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1225522001029	active site
1225522001030	dimerization interface [polypeptide binding]; other site
1225522001031	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
1225522001032	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1225522001033	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
1225522001034	Rrf2 family protein; Region: rrf2_super; TIGR00738
1225522001035	cysteine desulfurase; Provisional; Region: PRK14012
1225522001036	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1225522001037	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522001038	catalytic residue [active]
1225522001039	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1225522001040	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1225522001041	trimerization site [polypeptide binding]; other site
1225522001042	active site
1225522001043	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
1225522001044	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1225522001045	DnaJ domain; Region: DnaJ; pfam00226
1225522001046	HSP70 interaction site [polypeptide binding]; other site
1225522001047	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1225522001048	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1225522001049	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1225522001050	nucleotide binding site [chemical binding]; other site
1225522001051	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1225522001052	SBD interface [polypeptide binding]; other site
1225522001053	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1225522001054	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1225522001055	catalytic loop [active]
1225522001056	iron binding site [ion binding]; other site
1225522001057	hypothetical protein; Provisional; Region: PRK10721
1225522001058	aminopeptidase B; Provisional; Region: PRK05015
1225522001059	Peptidase; Region: DUF3663; pfam12404
1225522001060	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1225522001061	interface (dimer of trimers) [polypeptide binding]; other site
1225522001062	Substrate-binding/catalytic site; other site
1225522001063	Zn-binding sites [ion binding]; other site
1225522001064	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
1225522001065	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
1225522001066	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1225522001067	active site residue [active]
1225522001068	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1225522001069	active site residue [active]
1225522001070	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1225522001071	MG2 domain; Region: A2M_N; pfam01835
1225522001072	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1225522001073	surface patch; other site
1225522001074	thioester region; other site
1225522001075	specificity defining residues; other site
1225522001076	penicillin-binding protein 1C; Provisional; Region: PRK11240
1225522001077	Transglycosylase; Region: Transgly; pfam00912
1225522001078	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1225522001079	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1225522001080	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
1225522001081	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1225522001082	putative [Fe4-S4] binding site [ion binding]; other site
1225522001083	putative molybdopterin cofactor binding site [chemical binding]; other site
1225522001084	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1225522001085	putative molybdopterin cofactor binding site; other site
1225522001086	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1225522001087	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522001088	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
1225522001089	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522001090	hydrogenase 4 subunit H; Validated; Region: PRK08222
1225522001091	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1225522001092	active site
1225522001093	multimer interface [polypeptide binding]; other site
1225522001094	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1225522001095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522001096	FeS/SAM binding site; other site
1225522001097	cytoskeletal protein RodZ; Provisional; Region: PRK10856
1225522001098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522001099	non-specific DNA binding site [nucleotide binding]; other site
1225522001100	salt bridge; other site
1225522001101	sequence-specific DNA binding site [nucleotide binding]; other site
1225522001102	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1225522001103	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1225522001104	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1225522001105	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1225522001106	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1225522001107	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1225522001108	dimer interface [polypeptide binding]; other site
1225522001109	motif 1; other site
1225522001110	active site
1225522001111	motif 2; other site
1225522001112	motif 3; other site
1225522001113	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1225522001114	anticodon binding site; other site
1225522001115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1225522001116	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1225522001117	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
1225522001118	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
1225522001119	Trp docking motif [polypeptide binding]; other site
1225522001120	GTP-binding protein Der; Reviewed; Region: PRK00093
1225522001121	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1225522001122	G1 box; other site
1225522001123	GTP/Mg2+ binding site [chemical binding]; other site
1225522001124	Switch I region; other site
1225522001125	G2 box; other site
1225522001126	Switch II region; other site
1225522001127	G3 box; other site
1225522001128	G4 box; other site
1225522001129	G5 box; other site
1225522001130	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1225522001131	G1 box; other site
1225522001132	GTP/Mg2+ binding site [chemical binding]; other site
1225522001133	Switch I region; other site
1225522001134	G2 box; other site
1225522001135	G3 box; other site
1225522001136	Switch II region; other site
1225522001137	G4 box; other site
1225522001138	G5 box; other site
1225522001139	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
1225522001140	intimin-like protein SinH; Provisional; Region: PRK15318
1225522001141	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
1225522001142	intimin-like protein SinH; Provisional; Region: PRK15318
1225522001143	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
1225522001144	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
1225522001145	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
1225522001146	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
1225522001147	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
1225522001148	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
1225522001149	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
1225522001150	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
1225522001151	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
1225522001152	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1225522001153	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1225522001154	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1225522001155	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
1225522001156	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1225522001157	Autotransporter beta-domain; Region: Autotransporter; smart00869
1225522001158	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1225522001159	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1225522001160	generic binding surface II; other site
1225522001161	generic binding surface I; other site
1225522001162	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1225522001163	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1225522001164	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1225522001165	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1225522001166	active site
1225522001167	GMP synthase; Reviewed; Region: guaA; PRK00074
1225522001168	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1225522001169	AMP/PPi binding site [chemical binding]; other site
1225522001170	candidate oxyanion hole; other site
1225522001171	catalytic triad [active]
1225522001172	potential glutamine specificity residues [chemical binding]; other site
1225522001173	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1225522001174	ATP Binding subdomain [chemical binding]; other site
1225522001175	Ligand Binding sites [chemical binding]; other site
1225522001176	Dimerization subdomain; other site
1225522001177	Integrase core domain; Region: rve; pfam00665
1225522001178	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
1225522001179	exopolyphosphatase; Provisional; Region: PRK10854
1225522001180	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522001181	nucleotide binding site [chemical binding]; other site
1225522001182	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
1225522001183	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1225522001184	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1225522001185	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1225522001186	putative active site [active]
1225522001187	catalytic site [active]
1225522001188	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
1225522001189	domain interface [polypeptide binding]; other site
1225522001190	active site
1225522001191	catalytic site [active]
1225522001192	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1225522001193	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1225522001194	active site
1225522001195	substrate binding site [chemical binding]; other site
1225522001196	cosubstrate binding site; other site
1225522001197	catalytic site [active]
1225522001198	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1225522001199	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1225522001200	dimerization interface [polypeptide binding]; other site
1225522001201	putative ATP binding site [chemical binding]; other site
1225522001202	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522001203	active site
1225522001204	uracil transporter; Provisional; Region: PRK10720
1225522001205	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1225522001206	DNA replication initiation factor; Provisional; Region: PRK08084
1225522001207	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1225522001208	ArsC family; Region: ArsC; pfam03960
1225522001209	catalytic residues [active]
1225522001210	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1225522001211	Peptidase family M48; Region: Peptidase_M48; cl12018
1225522001212	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1225522001213	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1225522001214	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1225522001215	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1225522001216	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1225522001217	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1225522001218	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1225522001219	catalytic triad [active]
1225522001220	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
1225522001221	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
1225522001222	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1225522001223	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1225522001224	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1225522001225	dimer interface [polypeptide binding]; other site
1225522001226	active site
1225522001227	catalytic residue [active]
1225522001228	lipoprotein; Provisional; Region: PRK11679
1225522001229	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1225522001230	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1225522001231	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1225522001232	ATP binding site [chemical binding]; other site
1225522001233	active site
1225522001234	substrate binding site [chemical binding]; other site
1225522001235	Predicted metalloprotease [General function prediction only]; Region: COG2321
1225522001236	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1225522001237	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1225522001238	Helicase; Region: Helicase_RecD; pfam05127
1225522001239	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1225522001240	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
1225522001241	hypothetical protein; Provisional; Region: PRK13664
1225522001242	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1225522001243	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1225522001244	metal binding site [ion binding]; metal-binding site
1225522001245	dimer interface [polypeptide binding]; other site
1225522001246	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1225522001247	ArsC family; Region: ArsC; pfam03960
1225522001248	putative catalytic residues [active]
1225522001249	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
1225522001250	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1225522001251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522001252	dimerization interface [polypeptide binding]; other site
1225522001253	Histidine kinase; Region: HisKA_3; pfam07730
1225522001254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522001255	ATP binding site [chemical binding]; other site
1225522001256	Mg2+ binding site [ion binding]; other site
1225522001257	G-X-G motif; other site
1225522001258	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
1225522001259	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522001260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1225522001261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522001262	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1225522001263	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1225522001264	dimer interface [polypeptide binding]; other site
1225522001265	ADP-ribose binding site [chemical binding]; other site
1225522001266	active site
1225522001267	nudix motif; other site
1225522001268	metal binding site [ion binding]; metal-binding site
1225522001269	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1225522001270	transketolase; Reviewed; Region: PRK12753
1225522001271	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1225522001272	TPP-binding site [chemical binding]; other site
1225522001273	dimer interface [polypeptide binding]; other site
1225522001274	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1225522001275	PYR/PP interface [polypeptide binding]; other site
1225522001276	dimer interface [polypeptide binding]; other site
1225522001277	TPP binding site [chemical binding]; other site
1225522001278	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1225522001279	transaldolase-like protein; Provisional; Region: PTZ00411
1225522001280	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1225522001281	active site
1225522001282	dimer interface [polypeptide binding]; other site
1225522001283	catalytic residue [active]
1225522001284	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1225522001285	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1225522001286	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1225522001287	putative NAD(P) binding site [chemical binding]; other site
1225522001288	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1225522001289	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1225522001290	putative hexamer interface [polypeptide binding]; other site
1225522001291	putative hexagonal pore; other site
1225522001292	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1225522001293	G1 box; other site
1225522001294	GTP/Mg2+ binding site [chemical binding]; other site
1225522001295	G2 box; other site
1225522001296	Switch I region; other site
1225522001297	G3 box; other site
1225522001298	Switch II region; other site
1225522001299	G4 box; other site
1225522001300	G5 box; other site
1225522001301	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
1225522001302	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
1225522001303	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
1225522001304	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1225522001305	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1225522001306	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1225522001307	Hexamer interface [polypeptide binding]; other site
1225522001308	Putative hexagonal pore residue; other site
1225522001309	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1225522001310	Hexamer/Pentamer interface [polypeptide binding]; other site
1225522001311	central pore; other site
1225522001312	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
1225522001313	putative catalytic cysteine [active]
1225522001314	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
1225522001315	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522001316	nucleotide binding site [chemical binding]; other site
1225522001317	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
1225522001318	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
1225522001319	active site
1225522001320	metal binding site [ion binding]; metal-binding site
1225522001321	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
1225522001322	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
1225522001323	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
1225522001324	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1225522001325	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
1225522001326	carboxysome structural protein EutK; Provisional; Region: PRK15466
1225522001327	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1225522001328	Hexamer interface [polypeptide binding]; other site
1225522001329	Hexagonal pore residue; other site
1225522001330	transcriptional regulator EutR; Provisional; Region: PRK10130
1225522001331	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522001332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522001333	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
1225522001334	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1225522001335	active site
1225522001336	metal binding site [ion binding]; metal-binding site
1225522001337	putative acetyltransferase; Provisional; Region: PRK03624
1225522001338	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522001339	Coenzyme A binding pocket [chemical binding]; other site
1225522001340	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
1225522001341	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1225522001342	short chain dehydrogenase; Provisional; Region: PRK08226
1225522001343	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
1225522001344	NAD binding site [chemical binding]; other site
1225522001345	homotetramer interface [polypeptide binding]; other site
1225522001346	homodimer interface [polypeptide binding]; other site
1225522001347	active site
1225522001348	thiosulfate transporter subunit; Provisional; Region: PRK10852
1225522001349	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1225522001350	sulfate transport protein; Provisional; Region: cysT; CHL00187
1225522001351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522001352	dimer interface [polypeptide binding]; other site
1225522001353	conserved gate region; other site
1225522001354	putative PBP binding loops; other site
1225522001355	ABC-ATPase subunit interface; other site
1225522001356	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
1225522001357	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1225522001358	Walker A/P-loop; other site
1225522001359	ATP binding site [chemical binding]; other site
1225522001360	Q-loop/lid; other site
1225522001361	ABC transporter signature motif; other site
1225522001362	Walker B; other site
1225522001363	D-loop; other site
1225522001364	H-loop/switch region; other site
1225522001365	TOBE-like domain; Region: TOBE_3; pfam12857
1225522001366	cysteine synthase B; Region: cysM; TIGR01138
1225522001367	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1225522001368	dimer interface [polypeptide binding]; other site
1225522001369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522001370	catalytic residue [active]
1225522001371	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522001372	Sel1-like repeats; Region: SEL1; smart00671
1225522001373	hypothetical protein; Provisional; Region: PRK10318
1225522001374	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1225522001375	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1225522001376	catalytic triad [active]
1225522001377	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
1225522001378	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522001379	DNA-binding site [nucleotide binding]; DNA binding site
1225522001380	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522001381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522001382	homodimer interface [polypeptide binding]; other site
1225522001383	catalytic residue [active]
1225522001384	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1225522001385	dimer interface [polypeptide binding]; other site
1225522001386	pyridoxamine kinase; Validated; Region: PRK05756
1225522001387	pyridoxal binding site [chemical binding]; other site
1225522001388	ATP binding site [chemical binding]; other site
1225522001389	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1225522001390	HPr interaction site; other site
1225522001391	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1225522001392	active site
1225522001393	phosphorylation site [posttranslational modification]
1225522001394	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
1225522001395	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1225522001396	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1225522001397	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1225522001398	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1225522001399	dimerization domain swap beta strand [polypeptide binding]; other site
1225522001400	regulatory protein interface [polypeptide binding]; other site
1225522001401	active site
1225522001402	regulatory phosphorylation site [posttranslational modification]; other site
1225522001403	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1225522001404	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1225522001405	dimer interface [polypeptide binding]; other site
1225522001406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522001407	catalytic residue [active]
1225522001408	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1225522001409	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
1225522001410	cell division protein ZipA; Provisional; Region: PRK03427
1225522001411	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
1225522001412	FtsZ protein binding site [polypeptide binding]; other site
1225522001413	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1225522001414	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1225522001415	nucleotide binding pocket [chemical binding]; other site
1225522001416	K-X-D-G motif; other site
1225522001417	catalytic site [active]
1225522001418	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1225522001419	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1225522001420	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
1225522001421	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1225522001422	Dimer interface [polypeptide binding]; other site
1225522001423	BRCT sequence motif; other site
1225522001424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
1225522001425	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1225522001426	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1225522001427	hypothetical protein; Provisional; Region: PRK11528
1225522001428	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1225522001429	nucleoside transporter; Region: 2A0110; TIGR00889
1225522001430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522001431	putative substrate translocation pore; other site
1225522001432	XapX domain; Region: XapX; TIGR03510
1225522001433	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1225522001434	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522001435	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
1225522001436	putative dimerization interface [polypeptide binding]; other site
1225522001437	putative substrate binding pocket [chemical binding]; other site
1225522001438	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1225522001439	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1225522001440	active site
1225522001441	HIGH motif; other site
1225522001442	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1225522001443	active site
1225522001444	KMSKS motif; other site
1225522001445	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1225522001446	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1225522001447	MASE1; Region: MASE1; pfam05231
1225522001448	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1225522001449	diguanylate cyclase; Region: GGDEF; smart00267
1225522001450	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522001451	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1225522001452	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1225522001453	Nucleoside recognition; Region: Gate; pfam07670
1225522001454	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1225522001455	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
1225522001456	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522001457	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522001458	active site
1225522001459	catalytic tetrad [active]
1225522001460	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
1225522001461	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1225522001462	dimer interface [polypeptide binding]; other site
1225522001463	PYR/PP interface [polypeptide binding]; other site
1225522001464	TPP binding site [chemical binding]; other site
1225522001465	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1225522001466	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1225522001467	TPP-binding site [chemical binding]; other site
1225522001468	dimer interface [polypeptide binding]; other site
1225522001469	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1225522001470	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1225522001471	Cl- selectivity filter; other site
1225522001472	Cl- binding residues [ion binding]; other site
1225522001473	pore gating glutamate residue; other site
1225522001474	dimer interface [polypeptide binding]; other site
1225522001475	glucokinase; Provisional; Region: glk; PRK00292
1225522001476	glucokinase, proteobacterial type; Region: glk; TIGR00749
1225522001477	aminotransferase; Validated; Region: PRK08175
1225522001478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522001479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522001480	homodimer interface [polypeptide binding]; other site
1225522001481	catalytic residue [active]
1225522001482	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1225522001483	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1225522001484	putative acyl-acceptor binding pocket; other site
1225522001485	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
1225522001486	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1225522001487	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1225522001488	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
1225522001489	HAMP domain; Region: HAMP; pfam00672
1225522001490	dimerization interface [polypeptide binding]; other site
1225522001491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522001492	dimer interface [polypeptide binding]; other site
1225522001493	phosphorylation site [posttranslational modification]
1225522001494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522001495	ATP binding site [chemical binding]; other site
1225522001496	Mg2+ binding site [ion binding]; other site
1225522001497	G-X-G motif; other site
1225522001498	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1225522001499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522001500	active site
1225522001501	phosphorylation site [posttranslational modification]
1225522001502	intermolecular recognition site; other site
1225522001503	dimerization interface [polypeptide binding]; other site
1225522001504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1225522001505	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1225522001506	outer membrane protease; Reviewed; Region: PRK10993
1225522001507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
1225522001508	GtrA-like protein; Region: GtrA; pfam04138
1225522001509	Predicted membrane protein [Function unknown]; Region: COG2246
1225522001510	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1225522001511	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
1225522001512	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
1225522001513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
1225522001514	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1225522001515	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1225522001516	dimer interface [polypeptide binding]; other site
1225522001517	active site
1225522001518	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1225522001519	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1225522001520	substrate binding site [chemical binding]; other site
1225522001521	oxyanion hole (OAH) forming residues; other site
1225522001522	trimer interface [polypeptide binding]; other site
1225522001523	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1225522001524	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1225522001525	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1225522001526	catalytic core [active]
1225522001527	hypothetical protein; Provisional; Region: PRK04946
1225522001528	Smr domain; Region: Smr; pfam01713
1225522001529	HemK family putative methylases; Region: hemK_fam; TIGR00536
1225522001530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522001531	S-adenosylmethionine binding site [chemical binding]; other site
1225522001532	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1225522001533	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1225522001534	Tetramer interface [polypeptide binding]; other site
1225522001535	active site
1225522001536	FMN-binding site [chemical binding]; other site
1225522001537	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1225522001538	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1225522001539	hypothetical protein; Provisional; Region: PRK10621
1225522001540	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1225522001541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
1225522001542	YfcL protein; Region: YfcL; pfam08891
1225522001543	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1225522001544	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1225522001545	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1225522001546	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1225522001547	dimer interface [polypeptide binding]; other site
1225522001548	active site
1225522001549	CAAX protease self-immunity; Region: Abi; pfam02517
1225522001550	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
1225522001551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522001552	non-specific DNA binding site [nucleotide binding]; other site
1225522001553	salt bridge; other site
1225522001554	sequence-specific DNA binding site [nucleotide binding]; other site
1225522001555	putative transporter; Provisional; Region: PRK12382
1225522001556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522001557	putative substrate translocation pore; other site
1225522001558	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
1225522001559	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
1225522001560	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1225522001561	ligand binding site [chemical binding]; other site
1225522001562	NAD binding site [chemical binding]; other site
1225522001563	catalytic site [active]
1225522001564	homodimer interface [polypeptide binding]; other site
1225522001565	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
1225522001566	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1225522001567	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
1225522001568	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1225522001569	dimerization interface 3.5A [polypeptide binding]; other site
1225522001570	active site
1225522001571	hypothetical protein; Provisional; Region: PRK10847
1225522001572	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1225522001573	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1225522001574	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1225522001575	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1225522001576	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1225522001577	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1225522001578	cell division protein DedD; Provisional; Region: PRK11633
1225522001579	Sporulation related domain; Region: SPOR; pfam05036
1225522001580	colicin V production protein; Provisional; Region: PRK10845
1225522001581	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1225522001582	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1225522001583	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1225522001584	active site
1225522001585	tetramer interface [polypeptide binding]; other site
1225522001586	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522001587	active site
1225522001588	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1225522001589	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1225522001590	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522001591	catalytic residue [active]
1225522001592	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1225522001593	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1225522001594	dimer interface [polypeptide binding]; other site
1225522001595	active site
1225522001596	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522001597	substrate binding site [chemical binding]; other site
1225522001598	catalytic residue [active]
1225522001599	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1225522001600	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1225522001601	Flavoprotein; Region: Flavoprotein; pfam02441
1225522001602	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1225522001603	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522001604	substrate binding pocket [chemical binding]; other site
1225522001605	membrane-bound complex binding site; other site
1225522001606	hinge residues; other site
1225522001607	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522001608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522001609	dimer interface [polypeptide binding]; other site
1225522001610	conserved gate region; other site
1225522001611	putative PBP binding loops; other site
1225522001612	ABC-ATPase subunit interface; other site
1225522001613	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522001614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522001615	dimer interface [polypeptide binding]; other site
1225522001616	conserved gate region; other site
1225522001617	putative PBP binding loops; other site
1225522001618	ABC-ATPase subunit interface; other site
1225522001619	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
1225522001620	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1225522001621	Walker A/P-loop; other site
1225522001622	ATP binding site [chemical binding]; other site
1225522001623	Q-loop/lid; other site
1225522001624	ABC transporter signature motif; other site
1225522001625	Walker B; other site
1225522001626	D-loop; other site
1225522001627	H-loop/switch region; other site
1225522001628	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1225522001629	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1225522001630	putative NAD(P) binding site [chemical binding]; other site
1225522001631	putative active site [active]
1225522001632	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1225522001633	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1225522001634	C-terminal domain interface [polypeptide binding]; other site
1225522001635	GSH binding site (G-site) [chemical binding]; other site
1225522001636	dimer interface [polypeptide binding]; other site
1225522001637	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1225522001638	N-terminal domain interface [polypeptide binding]; other site
1225522001639	putative dimer interface [polypeptide binding]; other site
1225522001640	active site
1225522001641	glutathione S-transferase; Provisional; Region: PRK15113
1225522001642	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1225522001643	C-terminal domain interface [polypeptide binding]; other site
1225522001644	GSH binding site (G-site) [chemical binding]; other site
1225522001645	dimer interface [polypeptide binding]; other site
1225522001646	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
1225522001647	N-terminal domain interface [polypeptide binding]; other site
1225522001648	putative dimer interface [polypeptide binding]; other site
1225522001649	putative substrate binding pocket (H-site) [chemical binding]; other site
1225522001650	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1225522001651	active site
1225522001652	metal binding site [ion binding]; metal-binding site
1225522001653	homotetramer interface [polypeptide binding]; other site
1225522001654	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
1225522001655	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
1225522001656	nudix motif; other site
1225522001657	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1225522001658	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522001659	DNA binding site [nucleotide binding]
1225522001660	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1225522001661	putative dimerization interface [polypeptide binding]; other site
1225522001662	putative ligand binding site [chemical binding]; other site
1225522001663	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522001664	active site
1225522001665	phosphorylation site [posttranslational modification]
1225522001666	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1225522001667	active site
1225522001668	P-loop; other site
1225522001669	phosphorylation site [posttranslational modification]
1225522001670	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
1225522001671	transketolase; Reviewed; Region: PRK05899
1225522001672	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1225522001673	TPP-binding site [chemical binding]; other site
1225522001674	dimer interface [polypeptide binding]; other site
1225522001675	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1225522001676	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1225522001677	PYR/PP interface [polypeptide binding]; other site
1225522001678	dimer interface [polypeptide binding]; other site
1225522001679	TPP binding site [chemical binding]; other site
1225522001680	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1225522001681	phosphate acetyltransferase; Reviewed; Region: PRK05632
1225522001682	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1225522001683	DRTGG domain; Region: DRTGG; pfam07085
1225522001684	phosphate acetyltransferase; Region: pta; TIGR00651
1225522001685	propionate/acetate kinase; Provisional; Region: PRK12379
1225522001686	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1225522001687	hypothetical protein; Provisional; Region: PRK01816
1225522001688	hypothetical protein; Validated; Region: PRK05445
1225522001689	putative phosphatase; Provisional; Region: PRK11587
1225522001690	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522001691	motif II; other site
1225522001692	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1225522001693	transmembrane helices; other site
1225522001694	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1225522001695	TrkA-C domain; Region: TrkA_C; pfam02080
1225522001696	TrkA-C domain; Region: TrkA_C; pfam02080
1225522001697	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1225522001698	5'-nucleotidase; Provisional; Region: PRK03826
1225522001699	aminotransferase AlaT; Validated; Region: PRK09265
1225522001700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522001701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522001702	homodimer interface [polypeptide binding]; other site
1225522001703	catalytic residue [active]
1225522001704	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
1225522001705	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522001706	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
1225522001707	putative dimerization interface [polypeptide binding]; other site
1225522001708	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1225522001709	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1225522001710	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1225522001711	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1225522001712	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1225522001713	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1225522001714	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1225522001715	putative dimer interface [polypeptide binding]; other site
1225522001716	[2Fe-2S] cluster binding site [ion binding]; other site
1225522001717	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1225522001718	SLBB domain; Region: SLBB; pfam10531
1225522001719	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1225522001720	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
1225522001721	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1225522001722	catalytic loop [active]
1225522001723	iron binding site [ion binding]; other site
1225522001724	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1225522001725	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1225522001726	[4Fe-4S] binding site [ion binding]; other site
1225522001727	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1225522001728	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1225522001729	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1225522001730	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522001731	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522001732	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1225522001733	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1225522001734	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1225522001735	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1225522001736	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1225522001737	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1225522001738	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1225522001739	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1225522001740	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1225522001741	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1225522001742	von Willebrand factor; Region: vWF_A; pfam12450
1225522001743	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1225522001744	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
1225522001745	metal ion-dependent adhesion site (MIDAS); other site
1225522001746	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
1225522001747	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1225522001748	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1225522001749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522001750	active site
1225522001751	phosphorylation site [posttranslational modification]
1225522001752	intermolecular recognition site; other site
1225522001753	dimerization interface [polypeptide binding]; other site
1225522001754	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522001755	Coenzyme A binding pocket [chemical binding]; other site
1225522001756	hypothetical protein; Provisional; Region: PRK10404
1225522001757	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
1225522001758	isochorismate synthases; Region: isochor_syn; TIGR00543
1225522001759	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1225522001760	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1225522001761	dimer interface [polypeptide binding]; other site
1225522001762	tetramer interface [polypeptide binding]; other site
1225522001763	PYR/PP interface [polypeptide binding]; other site
1225522001764	TPP binding site [chemical binding]; other site
1225522001765	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1225522001766	TPP-binding site; other site
1225522001767	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
1225522001768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1225522001769	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1225522001770	substrate binding site [chemical binding]; other site
1225522001771	oxyanion hole (OAH) forming residues; other site
1225522001772	trimer interface [polypeptide binding]; other site
1225522001773	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
1225522001774	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1225522001775	active site
1225522001776	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
1225522001777	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1225522001778	acyl-activating enzyme (AAE) consensus motif; other site
1225522001779	putative AMP binding site [chemical binding]; other site
1225522001780	putative active site [active]
1225522001781	putative CoA binding site [chemical binding]; other site
1225522001782	signal transduction protein PmrD; Provisional; Region: PRK15450
1225522001783	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1225522001784	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1225522001785	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1225522001786	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1225522001787	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1225522001788	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
1225522001789	putative active site [active]
1225522001790	putative catalytic site [active]
1225522001791	putative Zn binding site [ion binding]; other site
1225522001792	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
1225522001793	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1225522001794	active site
1225522001795	substrate binding site [chemical binding]; other site
1225522001796	cosubstrate binding site; other site
1225522001797	catalytic site [active]
1225522001798	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1225522001799	active site
1225522001800	hexamer interface [polypeptide binding]; other site
1225522001801	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1225522001802	NAD binding site [chemical binding]; other site
1225522001803	substrate binding site [chemical binding]; other site
1225522001804	active site
1225522001805	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1225522001806	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1225522001807	Ligand binding site; other site
1225522001808	Putative Catalytic site; other site
1225522001809	DXD motif; other site
1225522001810	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1225522001811	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1225522001812	inhibitor-cofactor binding pocket; inhibition site
1225522001813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522001814	catalytic residue [active]
1225522001815	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1225522001816	catalytic core [active]
1225522001817	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
1225522001818	YfaZ precursor; Region: YfaZ; pfam07437
1225522001819	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
1225522001820	hypothetical protein; Provisional; Region: PRK03673
1225522001821	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1225522001822	putative MPT binding site; other site
1225522001823	Competence-damaged protein; Region: CinA; cl00666
1225522001824	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1225522001825	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1225522001826	Bacterial transcriptional regulator; Region: IclR; pfam01614
1225522001827	L-rhamnonate dehydratase; Provisional; Region: PRK15440
1225522001828	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
1225522001829	putative active site pocket [active]
1225522001830	putative metal binding site [ion binding]; other site
1225522001831	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
1225522001832	hypothetical protein; Provisional; Region: PRK03673
1225522001833	deubiquitinase SseL; Provisional; Region: PRK14848
1225522001834	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
1225522001835	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1225522001836	Cysteine-rich domain; Region: CCG; pfam02754
1225522001837	Cysteine-rich domain; Region: CCG; pfam02754
1225522001838	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
1225522001839	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1225522001840	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
1225522001841	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1225522001842	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1225522001843	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1225522001844	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522001845	putative substrate translocation pore; other site
1225522001846	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1225522001847	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
1225522001848	active site
1225522001849	catalytic site [active]
1225522001850	metal binding site [ion binding]; metal-binding site
1225522001851	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1225522001852	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522001853	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1225522001854	dimerization interface [polypeptide binding]; other site
1225522001855	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522001856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522001857	putative substrate translocation pore; other site
1225522001858	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1225522001859	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1225522001860	catalytic loop [active]
1225522001861	iron binding site [ion binding]; other site
1225522001862	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1225522001863	dimer interface [polypeptide binding]; other site
1225522001864	putative radical transfer pathway; other site
1225522001865	diiron center [ion binding]; other site
1225522001866	tyrosyl radical; other site
1225522001867	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1225522001868	ATP cone domain; Region: ATP-cone; pfam03477
1225522001869	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1225522001870	active site
1225522001871	dimer interface [polypeptide binding]; other site
1225522001872	catalytic residues [active]
1225522001873	effector binding site; other site
1225522001874	R2 peptide binding site; other site
1225522001875	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1225522001876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522001877	S-adenosylmethionine binding site [chemical binding]; other site
1225522001878	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1225522001879	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522001880	DNA-binding site [nucleotide binding]; DNA binding site
1225522001881	FCD domain; Region: FCD; pfam07729
1225522001882	DNA gyrase subunit A; Validated; Region: PRK05560
1225522001883	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1225522001884	CAP-like domain; other site
1225522001885	active site
1225522001886	primary dimer interface [polypeptide binding]; other site
1225522001887	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522001888	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522001889	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522001890	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522001891	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522001892	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522001893	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1225522001894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522001895	dimer interface [polypeptide binding]; other site
1225522001896	phosphorylation site [posttranslational modification]
1225522001897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522001898	ATP binding site [chemical binding]; other site
1225522001899	Mg2+ binding site [ion binding]; other site
1225522001900	G-X-G motif; other site
1225522001901	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
1225522001902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522001903	transcriptional regulator RcsB; Provisional; Region: PRK10840
1225522001904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522001905	active site
1225522001906	phosphorylation site [posttranslational modification]
1225522001907	intermolecular recognition site; other site
1225522001908	dimerization interface [polypeptide binding]; other site
1225522001909	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522001910	DNA binding residues [nucleotide binding]
1225522001911	dimerization interface [polypeptide binding]; other site
1225522001912	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
1225522001913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522001914	ATP binding site [chemical binding]; other site
1225522001915	G-X-G motif; other site
1225522001916	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1225522001917	putative binding surface; other site
1225522001918	active site
1225522001919	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1225522001920	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1225522001921	trimer interface [polypeptide binding]; other site
1225522001922	eyelet of channel; other site
1225522001923	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
1225522001924	ApbE family; Region: ApbE; pfam02424
1225522001925	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1225522001926	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1225522001927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522001928	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1225522001929	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1225522001930	DNA binding site [nucleotide binding]
1225522001931	active site
1225522001932	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
1225522001933	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1225522001934	Walker A/P-loop; other site
1225522001935	ATP binding site [chemical binding]; other site
1225522001936	Q-loop/lid; other site
1225522001937	ABC transporter signature motif; other site
1225522001938	Walker B; other site
1225522001939	D-loop; other site
1225522001940	H-loop/switch region; other site
1225522001941	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
1225522001942	secondary substrate binding site; other site
1225522001943	primary substrate binding site; other site
1225522001944	inhibition loop; other site
1225522001945	dimerization interface [polypeptide binding]; other site
1225522001946	ferredoxin-type protein; Provisional; Region: PRK10194
1225522001947	4Fe-4S binding domain; Region: Fer4; cl02805
1225522001948	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
1225522001949	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1225522001950	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1225522001951	[4Fe-4S] binding site [ion binding]; other site
1225522001952	molybdopterin cofactor binding site; other site
1225522001953	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1225522001954	molybdopterin cofactor binding site; other site
1225522001955	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
1225522001956	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
1225522001957	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1225522001958	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1225522001959	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
1225522001960	cytochrome c-type protein NapC; Provisional; Region: PRK10617
1225522001961	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
1225522001962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522001963	Walker A/P-loop; other site
1225522001964	ATP binding site [chemical binding]; other site
1225522001965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522001966	H-loop/switch region; other site
1225522001967	heme exporter protein CcmB; Region: ccmB; TIGR01190
1225522001968	heme exporter protein CcmC; Region: ccmC; TIGR01191
1225522001969	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1225522001970	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
1225522001971	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
1225522001972	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
1225522001973	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1225522001974	catalytic residues [active]
1225522001975	central insert; other site
1225522001976	transcriptional regulator NarP; Provisional; Region: PRK10403
1225522001977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522001978	active site
1225522001979	phosphorylation site [posttranslational modification]
1225522001980	intermolecular recognition site; other site
1225522001981	dimerization interface [polypeptide binding]; other site
1225522001982	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522001983	DNA binding residues [nucleotide binding]
1225522001984	dimerization interface [polypeptide binding]; other site
1225522001985	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1225522001986	DinI-like family; Region: DinI; cl11630
1225522001987	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
1225522001988	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
1225522001989	Sulfatase; Region: Sulfatase; cl17466
1225522001990	hypothetical protein; Provisional; Region: PRK13689
1225522001991	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1225522001992	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1225522001993	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1225522001994	5S rRNA interface [nucleotide binding]; other site
1225522001995	CTC domain interface [polypeptide binding]; other site
1225522001996	L16 interface [polypeptide binding]; other site
1225522001997	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1225522001998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522001999	ATP binding site [chemical binding]; other site
1225522002000	putative Mg++ binding site [ion binding]; other site
1225522002001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522002002	nucleotide binding region [chemical binding]; other site
1225522002003	ATP-binding site [chemical binding]; other site
1225522002004	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
1225522002005	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1225522002006	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522002007	RNA binding surface [nucleotide binding]; other site
1225522002008	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1225522002009	active site
1225522002010	uracil binding [chemical binding]; other site
1225522002011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002012	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1225522002013	putative substrate translocation pore; other site
1225522002014	hypothetical protein; Provisional; Region: PRK11835
1225522002015	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
1225522002016	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522002017	Walker A/P-loop; other site
1225522002018	ATP binding site [chemical binding]; other site
1225522002019	Q-loop/lid; other site
1225522002020	ABC transporter signature motif; other site
1225522002021	Walker B; other site
1225522002022	D-loop; other site
1225522002023	H-loop/switch region; other site
1225522002024	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1225522002025	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522002026	Walker A/P-loop; other site
1225522002027	ATP binding site [chemical binding]; other site
1225522002028	Q-loop/lid; other site
1225522002029	ABC transporter signature motif; other site
1225522002030	Walker B; other site
1225522002031	D-loop; other site
1225522002032	H-loop/switch region; other site
1225522002033	microcin C ABC transporter permease; Provisional; Region: PRK15021
1225522002034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522002035	dimer interface [polypeptide binding]; other site
1225522002036	conserved gate region; other site
1225522002037	ABC-ATPase subunit interface; other site
1225522002038	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1225522002039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522002040	dimer interface [polypeptide binding]; other site
1225522002041	conserved gate region; other site
1225522002042	putative PBP binding loops; other site
1225522002043	ABC-ATPase subunit interface; other site
1225522002044	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1225522002045	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1225522002046	phage resistance protein; Provisional; Region: PRK10551
1225522002047	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1225522002048	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522002049	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
1225522002050	NlpC/P60 family; Region: NLPC_P60; pfam00877
1225522002051	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1225522002052	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1225522002053	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1225522002054	elongation factor P; Provisional; Region: PRK04542
1225522002055	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1225522002056	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1225522002057	RNA binding site [nucleotide binding]; other site
1225522002058	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1225522002059	RNA binding site [nucleotide binding]; other site
1225522002060	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1225522002061	sugar efflux transporter B; Provisional; Region: PRK15011
1225522002062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002063	putative substrate translocation pore; other site
1225522002064	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1225522002065	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522002066	active site
1225522002067	phosphorylation site [posttranslational modification]
1225522002068	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1225522002069	dimerization domain swap beta strand [polypeptide binding]; other site
1225522002070	regulatory protein interface [polypeptide binding]; other site
1225522002071	active site
1225522002072	regulatory phosphorylation site [posttranslational modification]; other site
1225522002073	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1225522002074	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1225522002075	putative substrate binding site [chemical binding]; other site
1225522002076	putative ATP binding site [chemical binding]; other site
1225522002077	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1225522002078	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
1225522002079	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1225522002080	active site
1225522002081	P-loop; other site
1225522002082	phosphorylation site [posttranslational modification]
1225522002083	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
1225522002084	endonuclease IV; Provisional; Region: PRK01060
1225522002085	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1225522002086	AP (apurinic/apyrimidinic) site pocket; other site
1225522002087	DNA interaction; other site
1225522002088	Metal-binding active site; metal-binding site
1225522002089	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1225522002090	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1225522002091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522002092	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1225522002093	putative dimerization interface [polypeptide binding]; other site
1225522002094	lysine transporter; Provisional; Region: PRK10836
1225522002095	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
1225522002096	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522002097	N-terminal plug; other site
1225522002098	ligand-binding site [chemical binding]; other site
1225522002099	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1225522002100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002101	putative substrate translocation pore; other site
1225522002102	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1225522002103	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1225522002104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522002105	motif II; other site
1225522002106	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1225522002107	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1225522002108	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1225522002109	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1225522002110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522002111	non-specific DNA binding site [nucleotide binding]; other site
1225522002112	salt bridge; other site
1225522002113	sequence-specific DNA binding site [nucleotide binding]; other site
1225522002114	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1225522002115	S-formylglutathione hydrolase; Region: PLN02442
1225522002116	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1225522002117	GTP cyclohydrolase I; Provisional; Region: PLN03044
1225522002118	active site
1225522002119	Predicted membrane protein [Function unknown]; Region: COG2311
1225522002120	hypothetical protein; Provisional; Region: PRK10835
1225522002121	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
1225522002122	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522002123	DNA binding site [nucleotide binding]
1225522002124	domain linker motif; other site
1225522002125	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1225522002126	dimerization interface (closed form) [polypeptide binding]; other site
1225522002127	ligand binding site [chemical binding]; other site
1225522002128	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
1225522002129	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1225522002130	ligand binding site [chemical binding]; other site
1225522002131	calcium binding site [ion binding]; other site
1225522002132	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1225522002133	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1225522002134	TM-ABC transporter signature motif; other site
1225522002135	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1225522002136	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1225522002137	homodimer interface [polypeptide binding]; other site
1225522002138	active site
1225522002139	FMN binding site [chemical binding]; other site
1225522002140	substrate binding site [chemical binding]; other site
1225522002141	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1225522002142	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1225522002143	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522002144	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
1225522002145	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1225522002146	putative active site [active]
1225522002147	cytidine deaminase; Provisional; Region: PRK09027
1225522002148	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1225522002149	active site
1225522002150	catalytic motif [active]
1225522002151	Zn binding site [ion binding]; other site
1225522002152	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1225522002153	active site
1225522002154	catalytic motif [active]
1225522002155	Zn binding site [ion binding]; other site
1225522002156	hypothetical protein; Provisional; Region: PRK10711
1225522002157	hypothetical protein; Provisional; Region: PRK01821
1225522002158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522002159	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522002160	dimerization interface [polypeptide binding]; other site
1225522002161	benzoate transport; Region: 2A0115; TIGR00895
1225522002162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002163	putative substrate translocation pore; other site
1225522002164	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
1225522002165	Cupin domain; Region: Cupin_2; pfam07883
1225522002166	Cupin domain; Region: Cupin_2; pfam07883
1225522002167	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1225522002168	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1225522002169	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1225522002170	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1225522002171	C-terminal domain interface [polypeptide binding]; other site
1225522002172	GSH binding site (G-site) [chemical binding]; other site
1225522002173	putative dimer interface [polypeptide binding]; other site
1225522002174	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1225522002175	dimer interface [polypeptide binding]; other site
1225522002176	N-terminal domain interface [polypeptide binding]; other site
1225522002177	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1225522002178	salicylate hydroxylase; Provisional; Region: PRK08163
1225522002179	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1225522002180	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1225522002181	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1225522002182	FMN binding site [chemical binding]; other site
1225522002183	active site
1225522002184	catalytic residues [active]
1225522002185	substrate binding site [chemical binding]; other site
1225522002186	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
1225522002187	oxidoreductase; Provisional; Region: PRK12743
1225522002188	classical (c) SDRs; Region: SDR_c; cd05233
1225522002189	NAD(P) binding site [chemical binding]; other site
1225522002190	active site
1225522002191	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1225522002192	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1225522002193	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
1225522002194	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
1225522002195	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1225522002196	D-lactate dehydrogenase; Provisional; Region: PRK11183
1225522002197	FAD binding domain; Region: FAD_binding_4; pfam01565
1225522002198	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1225522002199	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1225522002200	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1225522002201	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1225522002202	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1225522002203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522002204	dimer interface [polypeptide binding]; other site
1225522002205	conserved gate region; other site
1225522002206	ABC-ATPase subunit interface; other site
1225522002207	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1225522002208	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1225522002209	Walker A/P-loop; other site
1225522002210	ATP binding site [chemical binding]; other site
1225522002211	Q-loop/lid; other site
1225522002212	ABC transporter signature motif; other site
1225522002213	Walker B; other site
1225522002214	D-loop; other site
1225522002215	H-loop/switch region; other site
1225522002216	CBS domain; Region: CBS; pfam00571
1225522002217	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1225522002218	putative PBP binding loops; other site
1225522002219	ABC-ATPase subunit interface; other site
1225522002220	transcriptional regulator MirA; Provisional; Region: PRK15043
1225522002221	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
1225522002222	DNA binding residues [nucleotide binding]
1225522002223	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1225522002224	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1225522002225	GAF domain; Region: GAF; pfam01590
1225522002226	Histidine kinase; Region: His_kinase; pfam06580
1225522002227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522002228	ATP binding site [chemical binding]; other site
1225522002229	Mg2+ binding site [ion binding]; other site
1225522002230	G-X-G motif; other site
1225522002231	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1225522002232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522002233	active site
1225522002234	phosphorylation site [posttranslational modification]
1225522002235	intermolecular recognition site; other site
1225522002236	dimerization interface [polypeptide binding]; other site
1225522002237	LytTr DNA-binding domain; Region: LytTR; pfam04397
1225522002238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1225522002239	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1225522002240	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1225522002241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1225522002242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1225522002243	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1225522002244	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1225522002245	active site
1225522002246	HIGH motif; other site
1225522002247	KMSKS motif; other site
1225522002248	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1225522002249	tRNA binding surface [nucleotide binding]; other site
1225522002250	anticodon binding site; other site
1225522002251	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1225522002252	dimer interface [polypeptide binding]; other site
1225522002253	putative tRNA-binding site [nucleotide binding]; other site
1225522002254	antiporter inner membrane protein; Provisional; Region: PRK11670
1225522002255	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1225522002256	Walker A motif; other site
1225522002257	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
1225522002258	fimbrial chaperone protein; Provisional; Region: PRK15220
1225522002259	fimbrial chaperone protein PegB; Provisional; Region: PRK15218
1225522002260	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522002261	Predicted integral membrane protein [Function unknown]; Region: COG5455
1225522002262	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1225522002263	substrate binding site [chemical binding]; other site
1225522002264	multimerization interface [polypeptide binding]; other site
1225522002265	ATP binding site [chemical binding]; other site
1225522002266	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1225522002267	dimer interface [polypeptide binding]; other site
1225522002268	substrate binding site [chemical binding]; other site
1225522002269	ATP binding site [chemical binding]; other site
1225522002270	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1225522002271	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522002272	DNA-binding site [nucleotide binding]; DNA binding site
1225522002273	UTRA domain; Region: UTRA; pfam07702
1225522002274	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522002275	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1225522002276	substrate binding site [chemical binding]; other site
1225522002277	ATP binding site [chemical binding]; other site
1225522002278	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
1225522002279	nucleoside transporter; Region: 2A0110; TIGR00889
1225522002280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002281	putative substrate translocation pore; other site
1225522002282	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
1225522002283	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1225522002284	putative active site; other site
1225522002285	catalytic residue [active]
1225522002286	lipid kinase; Reviewed; Region: PRK13054
1225522002287	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1225522002288	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
1225522002289	putative protease; Provisional; Region: PRK15452
1225522002290	Peptidase family U32; Region: Peptidase_U32; pfam01136
1225522002291	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
1225522002292	PcfJ-like protein; Region: PcfJ; pfam14284
1225522002293	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
1225522002294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522002295	active site
1225522002296	phosphorylation site [posttranslational modification]
1225522002297	intermolecular recognition site; other site
1225522002298	dimerization interface [polypeptide binding]; other site
1225522002299	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522002300	DNA binding site [nucleotide binding]
1225522002301	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
1225522002302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522002303	dimerization interface [polypeptide binding]; other site
1225522002304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522002305	dimer interface [polypeptide binding]; other site
1225522002306	phosphorylation site [posttranslational modification]
1225522002307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522002308	ATP binding site [chemical binding]; other site
1225522002309	Mg2+ binding site [ion binding]; other site
1225522002310	G-X-G motif; other site
1225522002311	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1225522002312	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1225522002313	Protein export membrane protein; Region: SecD_SecF; cl14618
1225522002314	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
1225522002315	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522002316	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522002317	putative chaperone; Provisional; Region: PRK11678
1225522002318	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1225522002319	nucleotide binding site [chemical binding]; other site
1225522002320	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1225522002321	SBD interface [polypeptide binding]; other site
1225522002322	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1225522002323	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1225522002324	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1225522002325	minor groove reading motif; other site
1225522002326	helix-hairpin-helix signature motif; other site
1225522002327	substrate binding pocket [chemical binding]; other site
1225522002328	active site
1225522002329	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
1225522002330	PAS domain S-box; Region: sensory_box; TIGR00229
1225522002331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522002332	putative active site [active]
1225522002333	heme pocket [chemical binding]; other site
1225522002334	PAS domain S-box; Region: sensory_box; TIGR00229
1225522002335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522002336	putative active site [active]
1225522002337	heme pocket [chemical binding]; other site
1225522002338	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1225522002339	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522002340	metal binding site [ion binding]; metal-binding site
1225522002341	active site
1225522002342	I-site; other site
1225522002343	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522002344	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1225522002345	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1225522002346	ATP-binding site [chemical binding]; other site
1225522002347	Sugar specificity; other site
1225522002348	Pyrimidine base specificity; other site
1225522002349	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1225522002350	trimer interface [polypeptide binding]; other site
1225522002351	active site
1225522002352	putative assembly protein; Provisional; Region: PRK10833
1225522002353	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1225522002354	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1225522002355	FOG: CBS domain [General function prediction only]; Region: COG0517
1225522002356	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1225522002357	Transporter associated domain; Region: CorC_HlyC; smart01091
1225522002358	polysaccharide export protein Wza; Provisional; Region: PRK15078
1225522002359	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1225522002360	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1225522002361	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1225522002362	active site
1225522002363	tyrosine kinase; Provisional; Region: PRK11519
1225522002364	Chain length determinant protein; Region: Wzz; pfam02706
1225522002365	Chain length determinant protein; Region: Wzz; cl15801
1225522002366	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1225522002367	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1225522002368	putative glycosyl transferase; Provisional; Region: PRK10018
1225522002369	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1225522002370	active site
1225522002371	putative acyl transferase; Provisional; Region: PRK10191
1225522002372	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1225522002373	trimer interface [polypeptide binding]; other site
1225522002374	active site
1225522002375	substrate binding site [chemical binding]; other site
1225522002376	CoA binding site [chemical binding]; other site
1225522002377	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
1225522002378	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1225522002379	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1225522002380	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
1225522002381	putative glycosyl transferase; Provisional; Region: PRK10063
1225522002382	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1225522002383	metal-binding site
1225522002384	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
1225522002385	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1225522002386	putative trimer interface [polypeptide binding]; other site
1225522002387	putative active site [active]
1225522002388	putative substrate binding site [chemical binding]; other site
1225522002389	putative CoA binding site [chemical binding]; other site
1225522002390	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1225522002391	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1225522002392	NADP-binding site; other site
1225522002393	homotetramer interface [polypeptide binding]; other site
1225522002394	substrate binding site [chemical binding]; other site
1225522002395	homodimer interface [polypeptide binding]; other site
1225522002396	active site
1225522002397	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1225522002398	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1225522002399	NADP binding site [chemical binding]; other site
1225522002400	active site
1225522002401	putative substrate binding site [chemical binding]; other site
1225522002402	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
1225522002403	active site
1225522002404	GDP-Mannose binding site [chemical binding]; other site
1225522002405	dimer interface [polypeptide binding]; other site
1225522002406	modified nudix motif
1225522002407	metal binding site [ion binding]; metal-binding site
1225522002408	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
1225522002409	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1225522002410	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
1225522002411	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1225522002412	Substrate binding site; other site
1225522002413	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1225522002414	phosphomannomutase CpsG; Provisional; Region: PRK15414
1225522002415	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1225522002416	active site
1225522002417	substrate binding site [chemical binding]; other site
1225522002418	metal binding site [ion binding]; metal-binding site
1225522002419	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
1225522002420	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1225522002421	colanic acid exporter; Provisional; Region: PRK10459
1225522002422	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1225522002423	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1225522002424	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1225522002425	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
1225522002426	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1225522002427	putative ADP-binding pocket [chemical binding]; other site
1225522002428	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
1225522002429	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1225522002430	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1225522002431	active site
1225522002432	tetramer interface; other site
1225522002433	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
1225522002434	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1225522002435	NAD binding site [chemical binding]; other site
1225522002436	substrate binding site [chemical binding]; other site
1225522002437	homodimer interface [polypeptide binding]; other site
1225522002438	active site
1225522002439	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
1225522002440	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1225522002441	NADP binding site [chemical binding]; other site
1225522002442	active site
1225522002443	putative substrate binding site [chemical binding]; other site
1225522002444	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
1225522002445	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1225522002446	substrate binding site; other site
1225522002447	tetramer interface; other site
1225522002448	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1225522002449	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1225522002450	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1225522002451	catalytic loop [active]
1225522002452	iron binding site [ion binding]; other site
1225522002453	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1225522002454	FAD binding pocket [chemical binding]; other site
1225522002455	FAD binding motif [chemical binding]; other site
1225522002456	phosphate binding motif [ion binding]; other site
1225522002457	beta-alpha-beta structure motif; other site
1225522002458	NAD binding pocket [chemical binding]; other site
1225522002459	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1225522002460	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1225522002461	substrate binding site; other site
1225522002462	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1225522002463	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
1225522002464	NAD binding site [chemical binding]; other site
1225522002465	homotetramer interface [polypeptide binding]; other site
1225522002466	homodimer interface [polypeptide binding]; other site
1225522002467	substrate binding site [chemical binding]; other site
1225522002468	active site
1225522002469	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
1225522002470	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1225522002471	inhibitor-cofactor binding pocket; inhibition site
1225522002472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522002473	catalytic residue [active]
1225522002474	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1225522002475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1225522002476	active site
1225522002477	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
1225522002478	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1225522002479	NAD binding site [chemical binding]; other site
1225522002480	homotetramer interface [polypeptide binding]; other site
1225522002481	homodimer interface [polypeptide binding]; other site
1225522002482	active site
1225522002483	substrate binding site [chemical binding]; other site
1225522002484	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1225522002485	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
1225522002486	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1225522002487	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1225522002488	active site
1225522002489	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1225522002490	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1225522002491	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1225522002492	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1225522002493	active site
1225522002494	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1225522002495	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1225522002496	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1225522002497	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1225522002498	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1225522002499	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
1225522002500	active site
1225522002501	substrate binding site [chemical binding]; other site
1225522002502	metal binding site [ion binding]; metal-binding site
1225522002503	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
1225522002504	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1225522002505	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1225522002506	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1225522002507	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1225522002508	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1225522002509	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1225522002510	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1225522002511	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1225522002512	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1225522002513	chain length determinant protein WzzB; Provisional; Region: PRK15471
1225522002514	Chain length determinant protein; Region: Wzz; cl15801
1225522002515	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1225522002516	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1225522002517	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1225522002518	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1225522002519	metal binding site [ion binding]; metal-binding site
1225522002520	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1225522002521	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1225522002522	substrate binding site [chemical binding]; other site
1225522002523	glutamase interaction surface [polypeptide binding]; other site
1225522002524	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1225522002525	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1225522002526	catalytic residues [active]
1225522002527	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
1225522002528	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1225522002529	putative active site [active]
1225522002530	oxyanion strand; other site
1225522002531	catalytic triad [active]
1225522002532	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
1225522002533	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522002534	active site
1225522002535	motif I; other site
1225522002536	motif II; other site
1225522002537	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1225522002538	putative active site pocket [active]
1225522002539	4-fold oligomerization interface [polypeptide binding]; other site
1225522002540	metal binding residues [ion binding]; metal-binding site
1225522002541	3-fold/trimer interface [polypeptide binding]; other site
1225522002542	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
1225522002543	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522002544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522002545	homodimer interface [polypeptide binding]; other site
1225522002546	catalytic residue [active]
1225522002547	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1225522002548	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1225522002549	NAD binding site [chemical binding]; other site
1225522002550	dimerization interface [polypeptide binding]; other site
1225522002551	product binding site; other site
1225522002552	substrate binding site [chemical binding]; other site
1225522002553	zinc binding site [ion binding]; other site
1225522002554	catalytic residues [active]
1225522002555	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1225522002556	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1225522002557	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1225522002558	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1225522002559	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1225522002560	putative NAD(P) binding site [chemical binding]; other site
1225522002561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522002562	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1225522002563	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522002564	dimerization interface [polypeptide binding]; other site
1225522002565	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1225522002566	exonuclease I; Provisional; Region: sbcB; PRK11779
1225522002567	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1225522002568	active site
1225522002569	catalytic site [active]
1225522002570	substrate binding site [chemical binding]; other site
1225522002571	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1225522002572	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1225522002573	thiosulfate reductase PhsA; Provisional; Region: PRK15488
1225522002574	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
1225522002575	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
1225522002576	putative [Fe4-S4] binding site [ion binding]; other site
1225522002577	putative molybdopterin cofactor binding site [chemical binding]; other site
1225522002578	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1225522002579	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
1225522002580	putative molybdopterin cofactor binding site; other site
1225522002581	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
1225522002582	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
1225522002583	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1225522002584	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
1225522002585	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1225522002586	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1225522002587	DNA gyrase inhibitor; Provisional; Region: PRK10016
1225522002588	Predicted membrane protein [Function unknown]; Region: COG1289
1225522002589	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1225522002590	hypothetical protein; Provisional; Region: PRK05423
1225522002591	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
1225522002592	propionate kinase; Reviewed; Region: PRK12397
1225522002593	propionate/acetate kinase; Provisional; Region: PRK12379
1225522002594	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
1225522002595	G3 box; other site
1225522002596	Switch II region; other site
1225522002597	GTP/Mg2+ binding site [chemical binding]; other site
1225522002598	G4 box; other site
1225522002599	G5 box; other site
1225522002600	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1225522002601	putative hexamer interface [polypeptide binding]; other site
1225522002602	putative hexagonal pore; other site
1225522002603	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
1225522002604	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
1225522002605	putative hexamer interface [polypeptide binding]; other site
1225522002606	putative hexagonal pore; other site
1225522002607	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
1225522002608	putative hexamer interface [polypeptide binding]; other site
1225522002609	putative hexagonal pore; other site
1225522002610	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
1225522002611	SLBB domain; Region: SLBB; pfam10531
1225522002612	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1225522002613	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
1225522002614	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1225522002615	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
1225522002616	putative active site [active]
1225522002617	metal binding site [ion binding]; metal-binding site
1225522002618	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
1225522002619	putative catalytic cysteine [active]
1225522002620	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1225522002621	Hexamer/Pentamer interface [polypeptide binding]; other site
1225522002622	central pore; other site
1225522002623	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
1225522002624	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1225522002625	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1225522002626	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1225522002627	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1225522002628	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
1225522002629	putative hexamer interface [polypeptide binding]; other site
1225522002630	putative hexagonal pore; other site
1225522002631	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1225522002632	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1225522002633	Hexamer interface [polypeptide binding]; other site
1225522002634	Putative hexagonal pore residue; other site
1225522002635	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
1225522002636	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
1225522002637	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
1225522002638	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
1225522002639	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
1225522002640	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
1225522002641	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
1225522002642	alpha-beta subunit interface [polypeptide binding]; other site
1225522002643	alpha-gamma subunit interface [polypeptide binding]; other site
1225522002644	active site
1225522002645	substrate and K+ binding site; other site
1225522002646	K+ binding site [ion binding]; other site
1225522002647	cobalamin binding site [chemical binding]; other site
1225522002648	propanediol utilization protein PduB; Provisional; Region: PRK15415
1225522002649	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
1225522002650	putative hexamer interface [polypeptide binding]; other site
1225522002651	putative hexagonal pore; other site
1225522002652	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
1225522002653	putative hexamer interface [polypeptide binding]; other site
1225522002654	putative hexagonal pore; other site
1225522002655	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1225522002656	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1225522002657	Hexamer interface [polypeptide binding]; other site
1225522002658	Putative hexagonal pore residue; other site
1225522002659	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1225522002660	amphipathic channel; other site
1225522002661	Asn-Pro-Ala signature motifs; other site
1225522002662	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1225522002663	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1225522002664	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1225522002665	catalytic triad [active]
1225522002666	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1225522002667	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
1225522002668	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1225522002669	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1225522002670	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1225522002671	active site
1225522002672	putative homodimer interface [polypeptide binding]; other site
1225522002673	SAM binding site [chemical binding]; other site
1225522002674	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
1225522002675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522002676	S-adenosylmethionine binding site [chemical binding]; other site
1225522002677	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1225522002678	active site
1225522002679	SAM binding site [chemical binding]; other site
1225522002680	homodimer interface [polypeptide binding]; other site
1225522002681	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1225522002682	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1225522002683	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1225522002684	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1225522002685	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1225522002686	homodimer interface [polypeptide binding]; other site
1225522002687	active site
1225522002688	SAM binding site [chemical binding]; other site
1225522002689	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1225522002690	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1225522002691	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
1225522002692	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
1225522002693	active site
1225522002694	C-terminal domain interface [polypeptide binding]; other site
1225522002695	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
1225522002696	active site
1225522002697	N-terminal domain interface [polypeptide binding]; other site
1225522002698	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1225522002699	active site
1225522002700	SAM binding site [chemical binding]; other site
1225522002701	homodimer interface [polypeptide binding]; other site
1225522002702	cobalt transport protein CbiM; Validated; Region: PRK08319
1225522002703	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1225522002704	cobalt transport protein CbiN; Provisional; Region: PRK02898
1225522002705	cobalt transport protein CbiQ; Provisional; Region: PRK15485
1225522002706	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
1225522002707	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1225522002708	Walker A/P-loop; other site
1225522002709	ATP binding site [chemical binding]; other site
1225522002710	Q-loop/lid; other site
1225522002711	ABC transporter signature motif; other site
1225522002712	Walker B; other site
1225522002713	D-loop; other site
1225522002714	H-loop/switch region; other site
1225522002715	cobyric acid synthase; Provisional; Region: PRK00784
1225522002716	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1225522002717	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1225522002718	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1225522002719	catalytic triad [active]
1225522002720	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1225522002721	homotrimer interface [polypeptide binding]; other site
1225522002722	Walker A motif; other site
1225522002723	GTP binding site [chemical binding]; other site
1225522002724	Walker B motif; other site
1225522002725	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1225522002726	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1225522002727	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1225522002728	putative dimer interface [polypeptide binding]; other site
1225522002729	active site pocket [active]
1225522002730	putative cataytic base [active]
1225522002731	L,D-transpeptidase; Provisional; Region: PRK10190
1225522002732	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1225522002733	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
1225522002734	AMP nucleosidase; Provisional; Region: PRK08292
1225522002735	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1225522002736	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1225522002737	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1225522002738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
1225522002739	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522002740	Sel1 repeat; Region: Sel1; pfam08238
1225522002741	Sel1-like repeats; Region: SEL1; smart00671
1225522002742	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
1225522002743	Integrase; Region: Integrase_1; pfam12835
1225522002744	putative protease; Region: PHA00666
1225522002745	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1225522002746	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
1225522002747	active site
1225522002748	NTP binding site [chemical binding]; other site
1225522002749	metal binding triad [ion binding]; metal-binding site
1225522002750	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1225522002751	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1225522002752	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1225522002753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522002754	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
1225522002755	MobA/MobL family; Region: MobA_MobL; pfam03389
1225522002756	PilS N terminal; Region: PilS; pfam08805
1225522002757	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
1225522002758	Phage Tail Collar Domain; Region: Collar; pfam07484
1225522002759	TIR domain; Region: TIR_2; pfam13676
1225522002760	integrase; Provisional; Region: PRK09692
1225522002761	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1225522002762	active site
1225522002763	Int/Topo IB signature motif; other site
1225522002764	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1225522002765	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
1225522002766	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
1225522002767	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1225522002768	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1225522002769	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1225522002770	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1225522002771	DNA-binding interface [nucleotide binding]; DNA binding site
1225522002772	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
1225522002773	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1225522002774	putative ligand binding site [chemical binding]; other site
1225522002775	NAD binding site [chemical binding]; other site
1225522002776	dimerization interface [polypeptide binding]; other site
1225522002777	catalytic site [active]
1225522002778	putative hydrolase; Validated; Region: PRK09248
1225522002779	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
1225522002780	active site
1225522002781	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1225522002782	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
1225522002783	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
1225522002784	curli assembly protein CsgF; Provisional; Region: PRK10050
1225522002785	curli assembly protein CsgE; Provisional; Region: PRK10386
1225522002786	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
1225522002787	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522002788	DNA binding residues [nucleotide binding]
1225522002789	dimerization interface [polypeptide binding]; other site
1225522002790	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
1225522002791	Curlin associated repeat; Region: Curlin_rpt; pfam07012
1225522002792	Curlin associated repeat; Region: Curlin_rpt; pfam07012
1225522002793	major curlin subunit; Provisional; Region: csgA; PRK10051
1225522002794	Curlin associated repeat; Region: Curlin_rpt; pfam07012
1225522002795	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
1225522002796	Fimbrial protein; Region: Fimbrial; cl01416
1225522002797	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1225522002798	putative ADP-ribose binding site [chemical binding]; other site
1225522002799	putative active site [active]
1225522002800	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1225522002801	PLD-like domain; Region: PLDc_2; pfam13091
1225522002802	putative active site [active]
1225522002803	catalytic site [active]
1225522002804	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1225522002805	PLD-like domain; Region: PLDc_2; pfam13091
1225522002806	putative active site [active]
1225522002807	catalytic site [active]
1225522002808	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1225522002809	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1225522002810	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1225522002811	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
1225522002812	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1225522002813	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
1225522002814	Ligand binding site; other site
1225522002815	DXD motif; other site
1225522002816	lipoprotein; Provisional; Region: PRK10175
1225522002817	drug efflux system protein MdtG; Provisional; Region: PRK09874
1225522002818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002819	putative substrate translocation pore; other site
1225522002820	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1225522002821	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1225522002822	putative acyl-acceptor binding pocket; other site
1225522002823	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1225522002824	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1225522002825	active site residue [active]
1225522002826	hypothetical protein; Provisional; Region: PRK03757
1225522002827	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1225522002828	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
1225522002829	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1225522002830	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1225522002831	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
1225522002832	DNA damage-inducible protein I; Provisional; Region: PRK10597
1225522002833	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1225522002834	active site
1225522002835	substrate binding pocket [chemical binding]; other site
1225522002836	dimer interface [polypeptide binding]; other site
1225522002837	lipoprotein; Provisional; Region: PRK10598
1225522002838	glutaredoxin 2; Provisional; Region: PRK10387
1225522002839	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
1225522002840	C-terminal domain interface [polypeptide binding]; other site
1225522002841	GSH binding site (G-site) [chemical binding]; other site
1225522002842	catalytic residues [active]
1225522002843	putative dimer interface [polypeptide binding]; other site
1225522002844	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
1225522002845	N-terminal domain interface [polypeptide binding]; other site
1225522002846	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1225522002847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522002848	putative substrate translocation pore; other site
1225522002849	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
1225522002850	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1225522002851	hypothetical protein; Provisional; Region: PRK11239
1225522002852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
1225522002853	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1225522002854	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1225522002855	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1225522002856	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1225522002857	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1225522002858	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
1225522002859	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
1225522002860	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
1225522002861	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1225522002862	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1225522002863	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1225522002864	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1225522002865	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1225522002866	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1225522002867	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1225522002868	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
1225522002869	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1225522002870	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1225522002871	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1225522002872	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1225522002873	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1225522002874	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1225522002875	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
1225522002876	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1225522002877	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1225522002878	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1225522002879	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1225522002880	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1225522002881	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1225522002882	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1225522002883	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1225522002884	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1225522002885	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
1225522002886	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
1225522002887	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1225522002888	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
1225522002889	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1225522002890	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1225522002891	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1225522002892	homodimer interface [polypeptide binding]; other site
1225522002893	oligonucleotide binding site [chemical binding]; other site
1225522002894	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
1225522002895	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1225522002896	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522002897	RNA binding surface [nucleotide binding]; other site
1225522002898	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1225522002899	active site
1225522002900	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
1225522002901	Maf-like protein; Region: Maf; pfam02545
1225522002902	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1225522002903	active site
1225522002904	dimer interface [polypeptide binding]; other site
1225522002905	hypothetical protein; Provisional; Region: PRK11193
1225522002906	putative phosphate acyltransferase; Provisional; Region: PRK05331
1225522002907	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1225522002908	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1225522002909	dimer interface [polypeptide binding]; other site
1225522002910	active site
1225522002911	CoA binding pocket [chemical binding]; other site
1225522002912	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1225522002913	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1225522002914	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1225522002915	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1225522002916	NAD(P) binding site [chemical binding]; other site
1225522002917	homotetramer interface [polypeptide binding]; other site
1225522002918	homodimer interface [polypeptide binding]; other site
1225522002919	active site
1225522002920	acyl carrier protein; Provisional; Region: acpP; PRK00982
1225522002921	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1225522002922	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1225522002923	dimer interface [polypeptide binding]; other site
1225522002924	active site
1225522002925	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1225522002926	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1225522002927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522002928	catalytic residue [active]
1225522002929	conserved hypothetical protein, YceG family; Region: TIGR00247
1225522002930	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1225522002931	dimerization interface [polypeptide binding]; other site
1225522002932	thymidylate kinase; Validated; Region: tmk; PRK00698
1225522002933	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1225522002934	TMP-binding site; other site
1225522002935	ATP-binding site [chemical binding]; other site
1225522002936	DNA polymerase III subunit delta'; Validated; Region: PRK07993
1225522002937	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1225522002938	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1225522002939	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1225522002940	active site
1225522002941	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
1225522002942	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1225522002943	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1225522002944	active site turn [active]
1225522002945	phosphorylation site [posttranslational modification]
1225522002946	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1225522002947	nucleotide binding site/active site [active]
1225522002948	HIT family signature motif; other site
1225522002949	catalytic residue [active]
1225522002950	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
1225522002951	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
1225522002952	putative dimer interface [polypeptide binding]; other site
1225522002953	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
1225522002954	thiamine kinase; Region: ycfN_thiK; TIGR02721
1225522002955	thiamine kinase; Provisional; Region: thiK; PRK10271
1225522002956	substrate binding site [chemical binding]; other site
1225522002957	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1225522002958	beta-hexosaminidase; Provisional; Region: PRK05337
1225522002959	hypothetical protein; Provisional; Region: PRK04940
1225522002960	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1225522002961	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522002962	hypothetical protein; Provisional; Region: PRK11280
1225522002963	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1225522002964	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522002965	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522002966	L,D-transpeptidase; Provisional; Region: PRK10190
1225522002967	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522002968	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1225522002969	transcription-repair coupling factor; Provisional; Region: PRK10689
1225522002970	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1225522002971	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522002972	ATP binding site [chemical binding]; other site
1225522002973	putative Mg++ binding site [ion binding]; other site
1225522002974	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522002975	nucleotide binding region [chemical binding]; other site
1225522002976	ATP-binding site [chemical binding]; other site
1225522002977	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1225522002978	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
1225522002979	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1225522002980	FtsX-like permease family; Region: FtsX; pfam02687
1225522002981	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
1225522002982	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1225522002983	Walker A/P-loop; other site
1225522002984	ATP binding site [chemical binding]; other site
1225522002985	Q-loop/lid; other site
1225522002986	ABC transporter signature motif; other site
1225522002987	Walker B; other site
1225522002988	D-loop; other site
1225522002989	H-loop/switch region; other site
1225522002990	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
1225522002991	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1225522002992	FtsX-like permease family; Region: FtsX; pfam02687
1225522002993	fructokinase; Reviewed; Region: PRK09557
1225522002994	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522002995	nucleotide binding site [chemical binding]; other site
1225522002996	NAD-dependent deacetylase; Provisional; Region: PRK00481
1225522002997	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1225522002998	NAD+ binding site [chemical binding]; other site
1225522002999	substrate binding site [chemical binding]; other site
1225522003000	Zn binding site [ion binding]; other site
1225522003001	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1225522003002	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1225522003003	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1225522003004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522003005	dimer interface [polypeptide binding]; other site
1225522003006	conserved gate region; other site
1225522003007	putative PBP binding loops; other site
1225522003008	ABC-ATPase subunit interface; other site
1225522003009	Sif protein; Region: Sif; pfam06767
1225522003010	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1225522003011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522003012	dimer interface [polypeptide binding]; other site
1225522003013	conserved gate region; other site
1225522003014	putative PBP binding loops; other site
1225522003015	ABC-ATPase subunit interface; other site
1225522003016	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
1225522003017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522003018	Walker A/P-loop; other site
1225522003019	ATP binding site [chemical binding]; other site
1225522003020	Q-loop/lid; other site
1225522003021	ABC transporter signature motif; other site
1225522003022	Walker B; other site
1225522003023	D-loop; other site
1225522003024	H-loop/switch region; other site
1225522003025	TOBE domain; Region: TOBE_2; pfam08402
1225522003026	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
1225522003027	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1225522003028	metal binding site [ion binding]; metal-binding site
1225522003029	dimer interface [polypeptide binding]; other site
1225522003030	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1225522003031	Cupin domain; Region: Cupin_2; cl17218
1225522003032	sensor protein PhoQ; Provisional; Region: PRK10815
1225522003033	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
1225522003034	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1225522003035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522003036	ATP binding site [chemical binding]; other site
1225522003037	Mg2+ binding site [ion binding]; other site
1225522003038	G-X-G motif; other site
1225522003039	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1225522003040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522003041	active site
1225522003042	phosphorylation site [posttranslational modification]
1225522003043	intermolecular recognition site; other site
1225522003044	dimerization interface [polypeptide binding]; other site
1225522003045	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522003046	DNA binding site [nucleotide binding]
1225522003047	adenylosuccinate lyase; Provisional; Region: PRK09285
1225522003048	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1225522003049	tetramer interface [polypeptide binding]; other site
1225522003050	active site
1225522003051	putative lysogenization regulator; Reviewed; Region: PRK00218
1225522003052	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1225522003053	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1225522003054	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1225522003055	nudix motif; other site
1225522003056	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
1225522003057	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1225522003058	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
1225522003059	pseudouridine synthase; Region: TIGR00093
1225522003060	probable active site [active]
1225522003061	isocitrate dehydrogenase; Validated; Region: PRK07362
1225522003062	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1225522003063	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
1225522003064	DinI-like family; Region: DinI; pfam06183
1225522003065	Ricin-type beta-trefoil; Region: RICIN; smart00458
1225522003066	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1225522003067	putative sugar binding sites [chemical binding]; other site
1225522003068	Q-X-W motif; other site
1225522003069	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1225522003070	lysozyme inhibitor; Provisional; Region: PRK13791
1225522003071	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1225522003072	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1225522003073	putative dimer interface [polypeptide binding]; other site
1225522003074	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1225522003075	BNR repeat-like domain; Region: BNR_2; pfam13088
1225522003076	TRL-like protein family; Region: TRL; pfam13146
1225522003077	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
1225522003078	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1225522003079	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1225522003080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522003081	dimer interface [polypeptide binding]; other site
1225522003082	conserved gate region; other site
1225522003083	ABC-ATPase subunit interface; other site
1225522003084	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1225522003085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522003086	dimer interface [polypeptide binding]; other site
1225522003087	conserved gate region; other site
1225522003088	putative PBP binding loops; other site
1225522003089	ABC-ATPase subunit interface; other site
1225522003090	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522003091	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1225522003092	Walker A/P-loop; other site
1225522003093	ATP binding site [chemical binding]; other site
1225522003094	Q-loop/lid; other site
1225522003095	ABC transporter signature motif; other site
1225522003096	Walker B; other site
1225522003097	D-loop; other site
1225522003098	H-loop/switch region; other site
1225522003099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522003100	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1225522003101	Walker A/P-loop; other site
1225522003102	ATP binding site [chemical binding]; other site
1225522003103	Q-loop/lid; other site
1225522003104	ABC transporter signature motif; other site
1225522003105	Walker B; other site
1225522003106	D-loop; other site
1225522003107	H-loop/switch region; other site
1225522003108	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1225522003109	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522003110	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1225522003111	dimerization interface [polypeptide binding]; other site
1225522003112	zinc/cadmium-binding protein; Provisional; Region: PRK10306
1225522003113	aminoglycoside resistance protein; Provisional; Region: PRK13746
1225522003114	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1225522003115	active site
1225522003116	NTP binding site [chemical binding]; other site
1225522003117	metal binding triad [ion binding]; metal-binding site
1225522003118	antibiotic binding site [chemical binding]; other site
1225522003119	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1225522003120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522003121	DNA binding residues [nucleotide binding]
1225522003122	transcriptional regulator MirA; Provisional; Region: PRK15043
1225522003123	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1225522003124	DNA binding residues [nucleotide binding]
1225522003125	dimer interface [polypeptide binding]; other site
1225522003126	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
1225522003127	chorismate mutase; Provisional; Region: PRK08055
1225522003128	leucine export protein LeuE; Provisional; Region: PRK10958
1225522003129	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1225522003130	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
1225522003131	hypothetical protein; Provisional; Region: PRK10457
1225522003132	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1225522003133	murein hydrolase B; Provisional; Region: PRK10760; cl17906
1225522003134	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1225522003135	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1225522003136	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1225522003137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003138	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522003139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522003140	Predicted membrane protein [Function unknown]; Region: COG2707
1225522003141	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
1225522003142	putative deacylase active site [active]
1225522003143	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522003144	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522003145	active site
1225522003146	catalytic tetrad [active]
1225522003147	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1225522003148	active site
1225522003149	phosphate binding residues; other site
1225522003150	catalytic residues [active]
1225522003151	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
1225522003152	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1225522003153	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1225522003154	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1225522003155	SelR domain; Region: SelR; pfam01641
1225522003156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
1225522003157	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1225522003158	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1225522003159	putative NAD(P) binding site [chemical binding]; other site
1225522003160	catalytic Zn binding site [ion binding]; other site
1225522003161	structural Zn binding site [ion binding]; other site
1225522003162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003164	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1225522003165	intersubunit interface [polypeptide binding]; other site
1225522003166	active site
1225522003167	zinc binding site [ion binding]; other site
1225522003168	Na+ binding site [ion binding]; other site
1225522003169	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1225522003170	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522003171	substrate binding site [chemical binding]; other site
1225522003172	ATP binding site [chemical binding]; other site
1225522003173	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522003174	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522003175	active site
1225522003176	catalytic tetrad [active]
1225522003177	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522003178	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522003179	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522003180	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1225522003181	Isochorismatase family; Region: Isochorismatase; pfam00857
1225522003182	catalytic triad [active]
1225522003183	metal binding site [ion binding]; metal-binding site
1225522003184	conserved cis-peptide bond; other site
1225522003185	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1225522003186	active site
1225522003187	homodimer interface [polypeptide binding]; other site
1225522003188	protease 4; Provisional; Region: PRK10949
1225522003189	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1225522003190	tandem repeat interface [polypeptide binding]; other site
1225522003191	oligomer interface [polypeptide binding]; other site
1225522003192	active site residues [active]
1225522003193	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
1225522003194	tandem repeat interface [polypeptide binding]; other site
1225522003195	oligomer interface [polypeptide binding]; other site
1225522003196	active site residues [active]
1225522003197	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1225522003198	putative FMN binding site [chemical binding]; other site
1225522003199	selenophosphate synthetase; Provisional; Region: PRK00943
1225522003200	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1225522003201	dimerization interface [polypeptide binding]; other site
1225522003202	putative ATP binding site [chemical binding]; other site
1225522003203	DNA topoisomerase III; Provisional; Region: PRK07726
1225522003204	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1225522003205	active site
1225522003206	putative interdomain interaction site [polypeptide binding]; other site
1225522003207	putative metal-binding site [ion binding]; other site
1225522003208	putative nucleotide binding site [chemical binding]; other site
1225522003209	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1225522003210	domain I; other site
1225522003211	DNA binding groove [nucleotide binding]
1225522003212	phosphate binding site [ion binding]; other site
1225522003213	domain II; other site
1225522003214	domain III; other site
1225522003215	nucleotide binding site [chemical binding]; other site
1225522003216	catalytic site [active]
1225522003217	domain IV; other site
1225522003218	glutamate dehydrogenase; Provisional; Region: PRK09414
1225522003219	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1225522003220	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1225522003221	NAD(P) binding site [chemical binding]; other site
1225522003222	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
1225522003223	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1225522003224	active site
1225522003225	8-oxo-dGMP binding site [chemical binding]; other site
1225522003226	nudix motif; other site
1225522003227	metal binding site [ion binding]; metal-binding site
1225522003228	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1225522003229	putative catalytic site [active]
1225522003230	putative phosphate binding site [ion binding]; other site
1225522003231	active site
1225522003232	metal binding site A [ion binding]; metal-binding site
1225522003233	DNA binding site [nucleotide binding]
1225522003234	putative AP binding site [nucleotide binding]; other site
1225522003235	putative metal binding site B [ion binding]; other site
1225522003236	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
1225522003237	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1225522003238	inhibitor-cofactor binding pocket; inhibition site
1225522003239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522003240	catalytic residue [active]
1225522003241	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1225522003242	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1225522003243	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1225522003244	NAD(P) binding site [chemical binding]; other site
1225522003245	catalytic residues [active]
1225522003246	succinylarginine dihydrolase; Provisional; Region: PRK13281
1225522003247	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
1225522003248	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1225522003249	putative active site [active]
1225522003250	Zn binding site [ion binding]; other site
1225522003251	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1225522003252	dimer interface [polypeptide binding]; other site
1225522003253	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
1225522003254	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1225522003255	GIY-YIG motif/motif A; other site
1225522003256	active site
1225522003257	catalytic site [active]
1225522003258	putative DNA binding site [nucleotide binding]; other site
1225522003259	metal binding site [ion binding]; metal-binding site
1225522003260	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1225522003261	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1225522003262	homodimer interface [polypeptide binding]; other site
1225522003263	NAD binding pocket [chemical binding]; other site
1225522003264	ATP binding pocket [chemical binding]; other site
1225522003265	Mg binding site [ion binding]; other site
1225522003266	active-site loop [active]
1225522003267	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
1225522003268	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1225522003269	active site
1225522003270	P-loop; other site
1225522003271	phosphorylation site [posttranslational modification]
1225522003272	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
1225522003273	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1225522003274	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1225522003275	methionine cluster; other site
1225522003276	active site
1225522003277	phosphorylation site [posttranslational modification]
1225522003278	metal binding site [ion binding]; metal-binding site
1225522003279	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
1225522003280	Cupin domain; Region: Cupin_2; pfam07883
1225522003281	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522003282	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1225522003283	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1225522003284	NAD binding site [chemical binding]; other site
1225522003285	sugar binding site [chemical binding]; other site
1225522003286	divalent metal binding site [ion binding]; other site
1225522003287	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1225522003288	dimer interface [polypeptide binding]; other site
1225522003289	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
1225522003290	putative active site [active]
1225522003291	YdjC motif; other site
1225522003292	Mg binding site [ion binding]; other site
1225522003293	putative homodimer interface [polypeptide binding]; other site
1225522003294	hydroperoxidase II; Provisional; Region: katE; PRK11249
1225522003295	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1225522003296	tetramer interface [polypeptide binding]; other site
1225522003297	heme binding pocket [chemical binding]; other site
1225522003298	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1225522003299	domain interactions; other site
1225522003300	cell division modulator; Provisional; Region: PRK10113
1225522003301	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1225522003302	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1225522003303	inner membrane protein; Provisional; Region: PRK11648
1225522003304	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
1225522003305	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1225522003306	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522003307	motif II; other site
1225522003308	YniB-like protein; Region: YniB; pfam14002
1225522003309	Phosphotransferase enzyme family; Region: APH; pfam01636
1225522003310	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1225522003311	active site
1225522003312	ATP binding site [chemical binding]; other site
1225522003313	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1225522003314	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
1225522003315	6-phosphofructokinase 2; Provisional; Region: PRK10294
1225522003316	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1225522003317	putative substrate binding site [chemical binding]; other site
1225522003318	putative ATP binding site [chemical binding]; other site
1225522003319	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
1225522003320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
1225522003321	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1225522003322	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1225522003323	active site
1225522003324	substrate binding site [chemical binding]; other site
1225522003325	Mg2+ binding site [ion binding]; other site
1225522003326	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1225522003327	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1225522003328	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1225522003329	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1225522003330	active site
1225522003331	dimer interface [polypeptide binding]; other site
1225522003332	motif 1; other site
1225522003333	motif 2; other site
1225522003334	motif 3; other site
1225522003335	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1225522003336	anticodon binding site; other site
1225522003337	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1225522003338	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1225522003339	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1225522003340	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1225522003341	23S rRNA binding site [nucleotide binding]; other site
1225522003342	L21 binding site [polypeptide binding]; other site
1225522003343	L13 binding site [polypeptide binding]; other site
1225522003344	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1225522003345	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1225522003346	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1225522003347	dimer interface [polypeptide binding]; other site
1225522003348	motif 1; other site
1225522003349	active site
1225522003350	motif 2; other site
1225522003351	motif 3; other site
1225522003352	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1225522003353	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1225522003354	putative tRNA-binding site [nucleotide binding]; other site
1225522003355	B3/4 domain; Region: B3_4; pfam03483
1225522003356	tRNA synthetase B5 domain; Region: B5; smart00874
1225522003357	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1225522003358	dimer interface [polypeptide binding]; other site
1225522003359	motif 1; other site
1225522003360	motif 3; other site
1225522003361	motif 2; other site
1225522003362	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1225522003363	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1225522003364	IHF dimer interface [polypeptide binding]; other site
1225522003365	IHF - DNA interface [nucleotide binding]; other site
1225522003366	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1225522003367	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522003368	ABC-ATPase subunit  interface; other site
1225522003369	dimer interface [polypeptide binding]; other site
1225522003370	putative PBP binding regions; other site
1225522003371	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1225522003372	catalytic residues [active]
1225522003373	dimer interface [polypeptide binding]; other site
1225522003374	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
1225522003375	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1225522003376	Walker A/P-loop; other site
1225522003377	ATP binding site [chemical binding]; other site
1225522003378	Q-loop/lid; other site
1225522003379	ABC transporter signature motif; other site
1225522003380	Walker B; other site
1225522003381	D-loop; other site
1225522003382	H-loop/switch region; other site
1225522003383	NlpC/P60 family; Region: NLPC_P60; pfam00877
1225522003384	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
1225522003385	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1225522003386	hypothetical protein; Validated; Region: PRK00029
1225522003387	hypothetical protein; Provisional; Region: PRK10183
1225522003388	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
1225522003389	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1225522003390	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1225522003391	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
1225522003392	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
1225522003393	acyl-activating enzyme (AAE) consensus motif; other site
1225522003394	putative AMP binding site [chemical binding]; other site
1225522003395	putative active site [active]
1225522003396	putative CoA binding site [chemical binding]; other site
1225522003397	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1225522003398	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
1225522003399	Electron transfer flavoprotein domain; Region: ETF; smart00893
1225522003400	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1225522003401	Cupin domain; Region: Cupin_2; pfam07883
1225522003402	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522003403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522003404	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
1225522003405	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1225522003406	active site
1225522003407	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1225522003408	Coenzyme A transferase; Region: CoA_trans; smart00882
1225522003409	Coenzyme A transferase; Region: CoA_trans; cl17247
1225522003410	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1225522003411	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1225522003412	active site
1225522003413	catalytic residue [active]
1225522003414	dimer interface [polypeptide binding]; other site
1225522003415	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
1225522003416	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1225522003417	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1225522003418	shikimate binding site; other site
1225522003419	NAD(P) binding site [chemical binding]; other site
1225522003420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003421	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522003422	putative substrate translocation pore; other site
1225522003423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003424	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522003425	putative substrate translocation pore; other site
1225522003426	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
1225522003427	putative inner membrane protein; Provisional; Region: PRK10983
1225522003428	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1225522003429	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1225522003430	FAD binding domain; Region: FAD_binding_4; pfam01565
1225522003431	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1225522003432	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1225522003433	CoenzymeA binding site [chemical binding]; other site
1225522003434	subunit interaction site [polypeptide binding]; other site
1225522003435	PHB binding site; other site
1225522003436	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1225522003437	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1225522003438	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
1225522003439	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1225522003440	putative ABC transporter; Region: ycf24; CHL00085
1225522003441	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
1225522003442	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1225522003443	Walker A/P-loop; other site
1225522003444	ATP binding site [chemical binding]; other site
1225522003445	Q-loop/lid; other site
1225522003446	ABC transporter signature motif; other site
1225522003447	Walker B; other site
1225522003448	D-loop; other site
1225522003449	H-loop/switch region; other site
1225522003450	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
1225522003451	FeS assembly protein SufD; Region: sufD; TIGR01981
1225522003452	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1225522003453	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1225522003454	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522003455	catalytic residue [active]
1225522003456	cysteine desufuration protein SufE; Provisional; Region: PRK09296
1225522003457	murein lipoprotein; Provisional; Region: PRK15396
1225522003458	murein lipoprotein; Provisional; Region: PRK15396
1225522003459	pyruvate kinase; Provisional; Region: PRK09206
1225522003460	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1225522003461	domain interfaces; other site
1225522003462	active site
1225522003463	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1225522003464	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522003465	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522003466	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522003467	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1225522003468	substrate binding site [chemical binding]; other site
1225522003469	dimer interface [polypeptide binding]; other site
1225522003470	ATP binding site [chemical binding]; other site
1225522003471	tetrathionate reductase subunit A; Provisional; Region: PRK14991
1225522003472	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
1225522003473	putative [Fe4-S4] binding site [ion binding]; other site
1225522003474	putative molybdopterin cofactor binding site [chemical binding]; other site
1225522003475	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
1225522003476	putative molybdopterin cofactor binding site; other site
1225522003477	tetrathionate reductase subunit C; Provisional; Region: PRK14992
1225522003478	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
1225522003479	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1225522003480	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1225522003481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1225522003482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522003483	dimer interface [polypeptide binding]; other site
1225522003484	phosphorylation site [posttranslational modification]
1225522003485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522003486	ATP binding site [chemical binding]; other site
1225522003487	Mg2+ binding site [ion binding]; other site
1225522003488	G-X-G motif; other site
1225522003489	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1225522003490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522003491	active site
1225522003492	phosphorylation site [posttranslational modification]
1225522003493	intermolecular recognition site; other site
1225522003494	dimerization interface [polypeptide binding]; other site
1225522003495	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522003496	DNA binding residues [nucleotide binding]
1225522003497	dimerization interface [polypeptide binding]; other site
1225522003498	hypothetical protein; Provisional; Region: PRK10292
1225522003499	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1225522003500	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1225522003501	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
1225522003502	transcriptional regulator MirA; Provisional; Region: PRK15043
1225522003503	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1225522003504	DNA binding residues [nucleotide binding]
1225522003505	two component system sensor kinase SsrB; Provisional; Region: PRK15369
1225522003506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522003507	active site
1225522003508	phosphorylation site [posttranslational modification]
1225522003509	intermolecular recognition site; other site
1225522003510	dimerization interface [polypeptide binding]; other site
1225522003511	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522003512	DNA binding residues [nucleotide binding]
1225522003513	dimerization interface [polypeptide binding]; other site
1225522003514	two component system sensor kinase SsrA; Provisional; Region: PRK15347
1225522003515	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522003516	dimerization interface [polypeptide binding]; other site
1225522003517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522003518	dimer interface [polypeptide binding]; other site
1225522003519	phosphorylation site [posttranslational modification]
1225522003520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522003521	ATP binding site [chemical binding]; other site
1225522003522	Mg2+ binding site [ion binding]; other site
1225522003523	G-X-G motif; other site
1225522003524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522003525	active site
1225522003526	phosphorylation site [posttranslational modification]
1225522003527	intermolecular recognition site; other site
1225522003528	dimerization interface [polypeptide binding]; other site
1225522003529	outer membrane secretin SsaC; Provisional; Region: PRK15346
1225522003530	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1225522003531	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1225522003532	type III secretion system protein SsaD; Provisional; Region: PRK15367
1225522003533	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
1225522003534	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
1225522003535	EspA-like secreted protein; Region: EspA; cl04069
1225522003536	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
1225522003537	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
1225522003538	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
1225522003539	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
1225522003540	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
1225522003541	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1225522003542	TPR motif; other site
1225522003543	binding surface
1225522003544	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
1225522003545	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
1225522003546	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
1225522003547	type III secretion system protein SsaH; Provisional; Region: PRK15356
1225522003548	type III secretion system protein SsaI; Provisional; Region: PRK15355
1225522003549	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
1225522003550	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
1225522003551	type III secretion system protein SsaK; Provisional; Region: PRK15354
1225522003552	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
1225522003553	type III secretion system protein SsaL; Provisional; Region: PRK15345
1225522003554	HrpJ-like domain; Region: HrpJ; pfam07201
1225522003555	TyeA; Region: TyeA; cl07611
1225522003556	type III secretion system protein SsaM; Provisional; Region: PRK15353
1225522003557	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
1225522003558	FHIPEP family; Region: FHIPEP; pfam00771
1225522003559	type III secretion system ATPase SsaN; Validated; Region: PRK07594
1225522003560	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1225522003561	Walker A motif; other site
1225522003562	ATP binding site [chemical binding]; other site
1225522003563	Walker B motif; other site
1225522003564	type III secretion system protein SsaO; Provisional; Region: PRK15352
1225522003565	type III secretion system protein SsaP; Provisional; Region: PRK15351
1225522003566	type III secretion system protein SsaQ; Validated; Region: PRK08035
1225522003567	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1225522003568	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
1225522003569	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
1225522003570	type III secretion system protein SsaT; Provisional; Region: PRK15349
1225522003571	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
1225522003572	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1225522003573	multidrug efflux protein; Reviewed; Region: PRK01766
1225522003574	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1225522003575	cation binding site [ion binding]; other site
1225522003576	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
1225522003577	Lumazine binding domain; Region: Lum_binding; pfam00677
1225522003578	Lumazine binding domain; Region: Lum_binding; pfam00677
1225522003579	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
1225522003580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522003581	S-adenosylmethionine binding site [chemical binding]; other site
1225522003582	putative transporter; Provisional; Region: PRK11043
1225522003583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003584	putative substrate translocation pore; other site
1225522003585	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1225522003586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522003587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522003588	dimerization interface [polypeptide binding]; other site
1225522003589	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1225522003590	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522003591	DNA binding site [nucleotide binding]
1225522003592	domain linker motif; other site
1225522003593	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1225522003594	dimerization interface [polypeptide binding]; other site
1225522003595	ligand binding site [chemical binding]; other site
1225522003596	superoxide dismutase; Provisional; Region: PRK10543
1225522003597	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1225522003598	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1225522003599	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1225522003600	NlpC/P60 family; Region: NLPC_P60; pfam00877
1225522003601	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1225522003602	putative GSH binding site [chemical binding]; other site
1225522003603	catalytic residues [active]
1225522003604	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1225522003605	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1225522003606	dimer interface [polypeptide binding]; other site
1225522003607	catalytic site [active]
1225522003608	putative active site [active]
1225522003609	putative substrate binding site [chemical binding]; other site
1225522003610	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1225522003611	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1225522003612	dimer interface [polypeptide binding]; other site
1225522003613	active site
1225522003614	metal binding site [ion binding]; metal-binding site
1225522003615	glutathione binding site [chemical binding]; other site
1225522003616	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1225522003617	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1225522003618	FMN binding site [chemical binding]; other site
1225522003619	active site
1225522003620	substrate binding site [chemical binding]; other site
1225522003621	catalytic residue [active]
1225522003622	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1225522003623	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522003624	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
1225522003625	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522003626	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522003627	active site
1225522003628	catalytic tetrad [active]
1225522003629	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1225522003630	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1225522003631	E-class dimer interface [polypeptide binding]; other site
1225522003632	P-class dimer interface [polypeptide binding]; other site
1225522003633	active site
1225522003634	Cu2+ binding site [ion binding]; other site
1225522003635	Zn2+ binding site [ion binding]; other site
1225522003636	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1225522003637	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1225522003638	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1225522003639	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522003640	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522003641	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1225522003642	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1225522003643	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
1225522003644	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1225522003645	lysozyme inhibitor; Provisional; Region: PRK11372
1225522003646	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1225522003647	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1225522003648	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1225522003649	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1225522003650	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1225522003651	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1225522003652	active site
1225522003653	HIGH motif; other site
1225522003654	dimer interface [polypeptide binding]; other site
1225522003655	KMSKS motif; other site
1225522003656	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522003657	RNA binding surface [nucleotide binding]; other site
1225522003658	pyridoxamine kinase; Validated; Region: PRK05756
1225522003659	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1225522003660	dimer interface [polypeptide binding]; other site
1225522003661	pyridoxal binding site [chemical binding]; other site
1225522003662	ATP binding site [chemical binding]; other site
1225522003663	glutathionine S-transferase; Provisional; Region: PRK10542
1225522003664	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1225522003665	C-terminal domain interface [polypeptide binding]; other site
1225522003666	GSH binding site (G-site) [chemical binding]; other site
1225522003667	dimer interface [polypeptide binding]; other site
1225522003668	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1225522003669	dimer interface [polypeptide binding]; other site
1225522003670	N-terminal domain interface [polypeptide binding]; other site
1225522003671	substrate binding pocket (H-site) [chemical binding]; other site
1225522003672	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1225522003673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003674	putative substrate translocation pore; other site
1225522003675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003676	endonuclease III; Provisional; Region: PRK10702
1225522003677	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1225522003678	minor groove reading motif; other site
1225522003679	helix-hairpin-helix signature motif; other site
1225522003680	substrate binding pocket [chemical binding]; other site
1225522003681	active site
1225522003682	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1225522003683	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1225522003684	electron transport complex protein RnfG; Validated; Region: PRK01908
1225522003685	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
1225522003686	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
1225522003687	SLBB domain; Region: SLBB; pfam10531
1225522003688	electron transport complex protein RnfB; Provisional; Region: PRK05113
1225522003689	Putative Fe-S cluster; Region: FeS; cl17515
1225522003690	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522003691	electron transport complex protein RsxA; Provisional; Region: PRK05151
1225522003692	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
1225522003693	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
1225522003694	putative oxidoreductase; Provisional; Region: PRK11579
1225522003695	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1225522003696	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1225522003697	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1225522003698	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1225522003699	active site
1225522003700	purine riboside binding site [chemical binding]; other site
1225522003701	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1225522003702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
1225522003703	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
1225522003704	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1225522003705	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1225522003706	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1225522003707	fumarate hydratase; Provisional; Region: PRK15389
1225522003708	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1225522003709	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1225522003710	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1225522003711	Class II fumarases; Region: Fumarase_classII; cd01362
1225522003712	active site
1225522003713	tetramer interface [polypeptide binding]; other site
1225522003714	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
1225522003715	sensor protein RstB; Provisional; Region: PRK10604
1225522003716	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522003717	dimerization interface [polypeptide binding]; other site
1225522003718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522003719	dimer interface [polypeptide binding]; other site
1225522003720	phosphorylation site [posttranslational modification]
1225522003721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522003722	ATP binding site [chemical binding]; other site
1225522003723	Mg2+ binding site [ion binding]; other site
1225522003724	G-X-G motif; other site
1225522003725	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1225522003726	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1225522003727	active site
1225522003728	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1225522003729	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1225522003730	trimer interface [polypeptide binding]; other site
1225522003731	eyelet of channel; other site
1225522003732	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1225522003733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522003734	active site
1225522003735	phosphorylation site [posttranslational modification]
1225522003736	intermolecular recognition site; other site
1225522003737	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522003738	DNA binding site [nucleotide binding]
1225522003739	GlpM protein; Region: GlpM; pfam06942
1225522003740	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1225522003741	Spore germination protein; Region: Spore_permease; cl17796
1225522003742	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522003743	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522003744	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522003745	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1225522003746	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1225522003747	ligand binding site [chemical binding]; other site
1225522003748	homodimer interface [polypeptide binding]; other site
1225522003749	NAD(P) binding site [chemical binding]; other site
1225522003750	trimer interface B [polypeptide binding]; other site
1225522003751	trimer interface A [polypeptide binding]; other site
1225522003752	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1225522003753	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
1225522003754	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1225522003755	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
1225522003756	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1225522003757	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
1225522003758	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
1225522003759	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1225522003760	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003761	putative substrate translocation pore; other site
1225522003762	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1225522003763	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522003764	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1225522003765	dimerization interface [polypeptide binding]; other site
1225522003766	substrate binding pocket [chemical binding]; other site
1225522003767	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1225522003768	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1225522003769	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522003770	nucleotide binding site [chemical binding]; other site
1225522003771	putative dithiobiotin synthetase; Provisional; Region: PRK12374
1225522003772	AAA domain; Region: AAA_26; pfam13500
1225522003773	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1225522003774	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1225522003775	Cl- selectivity filter; other site
1225522003776	Cl- binding residues [ion binding]; other site
1225522003777	pore gating glutamate residue; other site
1225522003778	dimer interface [polypeptide binding]; other site
1225522003779	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1225522003780	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1225522003781	Walker A/P-loop; other site
1225522003782	ATP binding site [chemical binding]; other site
1225522003783	Q-loop/lid; other site
1225522003784	ABC transporter signature motif; other site
1225522003785	Walker B; other site
1225522003786	D-loop; other site
1225522003787	H-loop/switch region; other site
1225522003788	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
1225522003789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522003790	dimer interface [polypeptide binding]; other site
1225522003791	conserved gate region; other site
1225522003792	ABC-ATPase subunit interface; other site
1225522003793	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1225522003794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522003795	dimer interface [polypeptide binding]; other site
1225522003796	conserved gate region; other site
1225522003797	putative PBP binding loops; other site
1225522003798	ABC-ATPase subunit interface; other site
1225522003799	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
1225522003800	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1225522003801	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522003802	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
1225522003803	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1225522003804	putative [Fe4-S4] binding site [ion binding]; other site
1225522003805	putative molybdopterin cofactor binding site [chemical binding]; other site
1225522003806	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1225522003807	putative molybdopterin cofactor binding site; other site
1225522003808	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
1225522003809	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1225522003810	putative [Fe4-S4] binding site [ion binding]; other site
1225522003811	putative molybdopterin cofactor binding site [chemical binding]; other site
1225522003812	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1225522003813	putative molybdopterin cofactor binding site; other site
1225522003814	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
1225522003815	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
1225522003816	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
1225522003817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522003818	Coenzyme A binding pocket [chemical binding]; other site
1225522003819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1225522003820	hypothetical protein; Provisional; Region: PRK13659
1225522003821	hypothetical protein; Provisional; Region: PRK02237
1225522003822	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1225522003823	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
1225522003824	putative active site pocket [active]
1225522003825	putative metal binding site [ion binding]; other site
1225522003826	putative oxidoreductase; Provisional; Region: PRK10083
1225522003827	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1225522003828	putative NAD(P) binding site [chemical binding]; other site
1225522003829	catalytic Zn binding site [ion binding]; other site
1225522003830	structural Zn binding site [ion binding]; other site
1225522003831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003832	metabolite-proton symporter; Region: 2A0106; TIGR00883
1225522003833	putative substrate translocation pore; other site
1225522003834	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1225522003835	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1225522003836	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1225522003837	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
1225522003838	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1225522003839	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522003840	DNA-binding site [nucleotide binding]; DNA binding site
1225522003841	FCD domain; Region: FCD; pfam07729
1225522003842	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1225522003843	short chain dehydrogenase; Provisional; Region: PRK06924
1225522003844	putative NAD(P) binding site [chemical binding]; other site
1225522003845	homotetramer interface [polypeptide binding]; other site
1225522003846	homodimer interface [polypeptide binding]; other site
1225522003847	active site
1225522003848	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
1225522003849	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1225522003850	active site
1225522003851	Zn binding site [ion binding]; other site
1225522003852	General stress protein [General function prediction only]; Region: GsiB; COG3729
1225522003853	hypothetical protein; Validated; Region: PRK03657
1225522003854	hypothetical protein; Provisional; Region: PRK10053
1225522003855	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1225522003856	EamA-like transporter family; Region: EamA; pfam00892
1225522003857	MarB protein; Region: MarB; pfam13999
1225522003858	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
1225522003859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522003860	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522003861	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
1225522003862	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1225522003863	inner membrane protein; Provisional; Region: PRK10995
1225522003864	putative arabinose transporter; Provisional; Region: PRK03545
1225522003865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003866	putative substrate translocation pore; other site
1225522003867	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522003868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522003869	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1225522003870	putative dimerization interface [polypeptide binding]; other site
1225522003871	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
1225522003872	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1225522003873	NAD(P) binding site [chemical binding]; other site
1225522003874	catalytic residues [active]
1225522003875	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1225522003876	glutaminase; Provisional; Region: PRK00971
1225522003877	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1225522003878	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1225522003879	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1225522003880	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1225522003881	trimer interface [polypeptide binding]; other site
1225522003882	eyelet of channel; other site
1225522003883	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1225522003884	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
1225522003885	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
1225522003886	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
1225522003887	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
1225522003888	Rubredoxin [Energy production and conversion]; Region: COG1773
1225522003889	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1225522003890	iron binding site [ion binding]; other site
1225522003891	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
1225522003892	HupF/HypC family; Region: HupF_HypC; cl00394
1225522003893	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1225522003894	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1225522003895	putative substrate-binding site; other site
1225522003896	nickel binding site [ion binding]; other site
1225522003897	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1225522003898	hydrogenase 1 large subunit; Provisional; Region: PRK10170
1225522003899	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1225522003900	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1225522003901	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1225522003902	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1225522003903	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1225522003904	active site
1225522003905	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1225522003906	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522003907	DNA-binding site [nucleotide binding]; DNA binding site
1225522003908	FCD domain; Region: FCD; pfam07729
1225522003909	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1225522003910	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1225522003911	putative NAD(P) binding site [chemical binding]; other site
1225522003912	catalytic Zn binding site [ion binding]; other site
1225522003913	structural Zn binding site [ion binding]; other site
1225522003914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003915	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1225522003916	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522003917	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522003918	homodimer interface [polypeptide binding]; other site
1225522003919	catalytic residue [active]
1225522003920	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1225522003921	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1225522003922	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1225522003923	active site
1225522003924	catalytic site [active]
1225522003925	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
1225522003926	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1225522003927	active site
1225522003928	catalytic site [active]
1225522003929	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
1225522003930	acid-resistance protein; Provisional; Region: hdeB; PRK11566
1225522003931	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1225522003932	biofilm-dependent modulation protein; Provisional; Region: PRK11436
1225522003933	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
1225522003934	malate dehydrogenase; Provisional; Region: PRK13529
1225522003935	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1225522003936	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1225522003937	NAD(P) binding site [chemical binding]; other site
1225522003938	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1225522003939	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1225522003940	NAD binding site [chemical binding]; other site
1225522003941	substrate binding site [chemical binding]; other site
1225522003942	catalytic Zn binding site [ion binding]; other site
1225522003943	tetramer interface [polypeptide binding]; other site
1225522003944	structural Zn binding site [ion binding]; other site
1225522003945	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
1225522003946	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1225522003947	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1225522003948	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1225522003949	aromatic amino acid exporter; Provisional; Region: PRK11689
1225522003950	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1225522003951	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1225522003952	trimer interface [polypeptide binding]; other site
1225522003953	eyelet of channel; other site
1225522003954	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1225522003955	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1225522003956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522003957	putative substrate translocation pore; other site
1225522003958	TetR family transcriptional regulator; Provisional; Region: PRK14996
1225522003959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522003960	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1225522003961	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1225522003962	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
1225522003963	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1225522003964	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
1225522003965	L-asparagine permease; Provisional; Region: PRK15049
1225522003966	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1225522003967	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1225522003968	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1225522003969	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522003970	N-terminal plug; other site
1225522003971	ligand-binding site [chemical binding]; other site
1225522003972	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
1225522003973	DNA-binding site [nucleotide binding]; DNA binding site
1225522003974	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1225522003975	FCD domain; Region: FCD; pfam07729
1225522003976	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1225522003977	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1225522003978	NAD(P) binding site [chemical binding]; other site
1225522003979	substrate binding site [chemical binding]; other site
1225522003980	dimer interface [polypeptide binding]; other site
1225522003981	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1225522003982	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1225522003983	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1225522003984	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
1225522003985	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
1225522003986	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
1225522003987	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
1225522003988	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1225522003989	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1225522003990	tetrameric interface [polypeptide binding]; other site
1225522003991	NAD binding site [chemical binding]; other site
1225522003992	catalytic residues [active]
1225522003993	substrate binding site [chemical binding]; other site
1225522003994	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1225522003995	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522003996	DNA-binding site [nucleotide binding]; DNA binding site
1225522003997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522003998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522003999	homodimer interface [polypeptide binding]; other site
1225522004000	catalytic residue [active]
1225522004001	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
1225522004002	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
1225522004003	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1225522004004	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1225522004005	Peptidase family U32; Region: Peptidase_U32; pfam01136
1225522004006	Collagenase; Region: DUF3656; pfam12392
1225522004007	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1225522004008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522004009	non-specific DNA binding site [nucleotide binding]; other site
1225522004010	salt bridge; other site
1225522004011	sequence-specific DNA binding site [nucleotide binding]; other site
1225522004012	Cupin domain; Region: Cupin_2; pfam07883
1225522004013	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1225522004014	tellurite resistance protein TehB; Provisional; Region: PRK11207
1225522004015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004016	S-adenosylmethionine binding site [chemical binding]; other site
1225522004017	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1225522004018	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
1225522004019	gating phenylalanine in ion channel; other site
1225522004020	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1225522004021	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1225522004022	putative trimer interface [polypeptide binding]; other site
1225522004023	putative CoA binding site [chemical binding]; other site
1225522004024	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
1225522004025	putative trimer interface [polypeptide binding]; other site
1225522004026	putative CoA binding site [chemical binding]; other site
1225522004027	ribosomal-protein-L7/L12-serine acetyltransferase; Provisional; Region: PRK10151
1225522004028	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1225522004029	Coenzyme A binding pocket [chemical binding]; other site
1225522004030	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1225522004031	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1225522004032	oligomer interface [polypeptide binding]; other site
1225522004033	active site
1225522004034	metal binding site [ion binding]; metal-binding site
1225522004035	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1225522004036	active site
1225522004037	P-loop; other site
1225522004038	phosphorylation site [posttranslational modification]
1225522004039	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1225522004040	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
1225522004041	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
1225522004042	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522004043	active site
1225522004044	phosphorylation site [posttranslational modification]
1225522004045	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1225522004046	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1225522004047	substrate binding site [chemical binding]; other site
1225522004048	hexamer interface [polypeptide binding]; other site
1225522004049	metal binding site [ion binding]; metal-binding site
1225522004050	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522004051	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1225522004052	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522004053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522004054	Coenzyme A binding pocket [chemical binding]; other site
1225522004055	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1225522004056	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1225522004057	metal binding site [ion binding]; metal-binding site
1225522004058	substrate binding pocket [chemical binding]; other site
1225522004059	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
1225522004060	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1225522004061	NADP binding site [chemical binding]; other site
1225522004062	homodimer interface [polypeptide binding]; other site
1225522004063	active site
1225522004064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522004065	D-galactonate transporter; Region: 2A0114; TIGR00893
1225522004066	putative substrate translocation pore; other site
1225522004067	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1225522004068	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1225522004069	putative NAD(P) binding site [chemical binding]; other site
1225522004070	catalytic Zn binding site [ion binding]; other site
1225522004071	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1225522004072	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522004073	DNA-binding site [nucleotide binding]; DNA binding site
1225522004074	FCD domain; Region: FCD; pfam07729
1225522004075	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1225522004076	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
1225522004077	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
1225522004078	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1225522004079	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1225522004080	substrate binding pocket [chemical binding]; other site
1225522004081	catalytic triad [active]
1225522004082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1225522004083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1225522004084	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1225522004085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522004086	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522004087	dimerization interface [polypeptide binding]; other site
1225522004088	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1225522004089	dimer interface [polypeptide binding]; other site
1225522004090	ligand binding site [chemical binding]; other site
1225522004091	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1225522004092	HAMP domain; Region: HAMP; pfam00672
1225522004093	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522004094	dimer interface [polypeptide binding]; other site
1225522004095	putative CheW interface [polypeptide binding]; other site
1225522004096	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1225522004097	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1225522004098	substrate binding site [chemical binding]; other site
1225522004099	catalytic Zn binding site [ion binding]; other site
1225522004100	NAD binding site [chemical binding]; other site
1225522004101	structural Zn binding site [ion binding]; other site
1225522004102	dimer interface [polypeptide binding]; other site
1225522004103	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1225522004104	putative metal binding site [ion binding]; other site
1225522004105	putative homodimer interface [polypeptide binding]; other site
1225522004106	putative homotetramer interface [polypeptide binding]; other site
1225522004107	putative homodimer-homodimer interface [polypeptide binding]; other site
1225522004108	putative allosteric switch controlling residues; other site
1225522004109	Sif protein; Region: Sif; cl11505
1225522004110	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
1225522004111	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
1225522004112	active site
1225522004113	catalytic triad [active]
1225522004114	oxyanion hole [active]
1225522004115	Predicted membrane protein [Function unknown]; Region: COG3326
1225522004116	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522004117	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1225522004118	substrate binding pocket [chemical binding]; other site
1225522004119	membrane-bound complex binding site; other site
1225522004120	hinge residues; other site
1225522004121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522004122	dimer interface [polypeptide binding]; other site
1225522004123	ABC-ATPase subunit interface; other site
1225522004124	putative PBP binding loops; other site
1225522004125	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522004126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522004127	dimer interface [polypeptide binding]; other site
1225522004128	conserved gate region; other site
1225522004129	putative PBP binding loops; other site
1225522004130	ABC-ATPase subunit interface; other site
1225522004131	Predicted membrane protein [Function unknown]; Region: COG5305
1225522004132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004133	S-adenosylmethionine binding site [chemical binding]; other site
1225522004134	cytochrome b561; Provisional; Region: PRK11513
1225522004135	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1225522004136	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1225522004137	putative active site [active]
1225522004138	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1225522004139	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522004140	ATP binding site [chemical binding]; other site
1225522004141	putative Mg++ binding site [ion binding]; other site
1225522004142	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522004143	nucleotide binding region [chemical binding]; other site
1225522004144	ATP-binding site [chemical binding]; other site
1225522004145	Helicase associated domain (HA2); Region: HA2; pfam04408
1225522004146	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1225522004147	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1225522004148	azoreductase; Reviewed; Region: PRK00170
1225522004149	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1225522004150	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1225522004151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
1225522004152	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
1225522004153	hypothetical protein; Provisional; Region: PRK10695
1225522004154	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1225522004155	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1225522004156	putative ligand binding site [chemical binding]; other site
1225522004157	putative NAD binding site [chemical binding]; other site
1225522004158	catalytic site [active]
1225522004159	heat-inducible protein; Provisional; Region: PRK10449
1225522004160	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1225522004161	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1225522004162	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1225522004163	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1225522004164	dimer interface [polypeptide binding]; other site
1225522004165	PYR/PP interface [polypeptide binding]; other site
1225522004166	TPP binding site [chemical binding]; other site
1225522004167	substrate binding site [chemical binding]; other site
1225522004168	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1225522004169	Domain of unknown function; Region: EKR; smart00890
1225522004170	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1225522004171	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522004172	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1225522004173	TPP-binding site [chemical binding]; other site
1225522004174	dimer interface [polypeptide binding]; other site
1225522004175	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1225522004176	Ligand Binding Site [chemical binding]; other site
1225522004177	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1225522004178	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1225522004179	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1225522004180	Ligand Binding Site [chemical binding]; other site
1225522004181	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1225522004182	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1225522004183	ATP binding site [chemical binding]; other site
1225522004184	Mg++ binding site [ion binding]; other site
1225522004185	motif III; other site
1225522004186	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522004187	nucleotide binding region [chemical binding]; other site
1225522004188	ATP-binding site [chemical binding]; other site
1225522004189	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1225522004190	putative RNA binding site [nucleotide binding]; other site
1225522004191	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1225522004192	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1225522004193	Cl binding site [ion binding]; other site
1225522004194	oligomer interface [polypeptide binding]; other site
1225522004195	HAMP domain; Region: HAMP; pfam00672
1225522004196	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1225522004197	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522004198	dimer interface [polypeptide binding]; other site
1225522004199	putative CheW interface [polypeptide binding]; other site
1225522004200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1225522004201	Smr domain; Region: Smr; pfam01713
1225522004202	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
1225522004203	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1225522004204	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1225522004205	DNA binding site [nucleotide binding]
1225522004206	active site
1225522004207	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1225522004208	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1225522004209	ligand binding site [chemical binding]; other site
1225522004210	flexible hinge region; other site
1225522004211	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1225522004212	putative switch regulator; other site
1225522004213	non-specific DNA interactions [nucleotide binding]; other site
1225522004214	DNA binding site [nucleotide binding]
1225522004215	sequence specific DNA binding site [nucleotide binding]; other site
1225522004216	putative cAMP binding site [chemical binding]; other site
1225522004217	universal stress protein UspE; Provisional; Region: PRK11175
1225522004218	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1225522004219	Ligand Binding Site [chemical binding]; other site
1225522004220	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1225522004221	Ligand Binding Site [chemical binding]; other site
1225522004222	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
1225522004223	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1225522004224	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522004225	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522004226	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522004227	active site
1225522004228	catalytic tetrad [active]
1225522004229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522004230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522004231	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1225522004232	putative effector binding pocket; other site
1225522004233	putative dimerization interface [polypeptide binding]; other site
1225522004234	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1225522004235	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1225522004236	peptide binding site [polypeptide binding]; other site
1225522004237	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1225522004238	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
1225522004239	putative active site [active]
1225522004240	Zn binding site [ion binding]; other site
1225522004241	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1225522004242	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1225522004243	active site
1225522004244	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1225522004245	dimer interface [polypeptide binding]; other site
1225522004246	catalytic triad [active]
1225522004247	peroxidatic and resolving cysteines [active]
1225522004248	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
1225522004249	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
1225522004250	putative aromatic amino acid binding site; other site
1225522004251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522004252	Walker A motif; other site
1225522004253	ATP binding site [chemical binding]; other site
1225522004254	Walker B motif; other site
1225522004255	arginine finger; other site
1225522004256	hypothetical protein; Provisional; Region: PRK05415
1225522004257	TIGR01620 family protein; Region: hyp_HI0043
1225522004258	Predicted ATPase [General function prediction only]; Region: COG3106
1225522004259	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1225522004260	active site residue [active]
1225522004261	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
1225522004262	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
1225522004263	phage shock protein C; Region: phageshock_pspC; TIGR02978
1225522004264	phage shock protein B; Provisional; Region: pspB; PRK09458
1225522004265	phage shock protein PspA; Provisional; Region: PRK10698
1225522004266	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
1225522004267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522004268	Walker A motif; other site
1225522004269	ATP binding site [chemical binding]; other site
1225522004270	Walker B motif; other site
1225522004271	arginine finger; other site
1225522004272	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1225522004273	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1225522004274	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1225522004275	peptide binding site [polypeptide binding]; other site
1225522004276	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
1225522004277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522004278	dimer interface [polypeptide binding]; other site
1225522004279	conserved gate region; other site
1225522004280	putative PBP binding loops; other site
1225522004281	ABC-ATPase subunit interface; other site
1225522004282	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
1225522004283	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1225522004284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522004285	dimer interface [polypeptide binding]; other site
1225522004286	conserved gate region; other site
1225522004287	putative PBP binding loops; other site
1225522004288	ABC-ATPase subunit interface; other site
1225522004289	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
1225522004290	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522004291	Walker A/P-loop; other site
1225522004292	ATP binding site [chemical binding]; other site
1225522004293	Q-loop/lid; other site
1225522004294	ABC transporter signature motif; other site
1225522004295	Walker B; other site
1225522004296	D-loop; other site
1225522004297	H-loop/switch region; other site
1225522004298	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1225522004299	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
1225522004300	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522004301	Walker A/P-loop; other site
1225522004302	ATP binding site [chemical binding]; other site
1225522004303	Q-loop/lid; other site
1225522004304	ABC transporter signature motif; other site
1225522004305	Walker B; other site
1225522004306	D-loop; other site
1225522004307	H-loop/switch region; other site
1225522004308	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1225522004309	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
1225522004310	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1225522004311	NAD binding site [chemical binding]; other site
1225522004312	homotetramer interface [polypeptide binding]; other site
1225522004313	homodimer interface [polypeptide binding]; other site
1225522004314	substrate binding site [chemical binding]; other site
1225522004315	active site
1225522004316	exoribonuclease II; Provisional; Region: PRK05054
1225522004317	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1225522004318	RNB domain; Region: RNB; pfam00773
1225522004319	S1 RNA binding domain; Region: S1; pfam00575
1225522004320	RNase II stability modulator; Provisional; Region: PRK10060
1225522004321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522004322	putative active site [active]
1225522004323	heme pocket [chemical binding]; other site
1225522004324	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522004325	metal binding site [ion binding]; metal-binding site
1225522004326	active site
1225522004327	I-site; other site
1225522004328	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522004329	hypothetical protein; Provisional; Region: PRK13658
1225522004330	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522004331	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522004332	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522004333	lipoprotein; Provisional; Region: PRK10540
1225522004334	translation initiation factor Sui1; Validated; Region: PRK06824
1225522004335	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1225522004336	putative rRNA binding site [nucleotide binding]; other site
1225522004337	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1225522004338	active site
1225522004339	dimer interface [polypeptide binding]; other site
1225522004340	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
1225522004341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1225522004342	binding surface
1225522004343	TPR motif; other site
1225522004344	Predicted membrane protein [Function unknown]; Region: COG3771
1225522004345	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1225522004346	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1225522004347	active site
1225522004348	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1225522004349	dimerization interface [polypeptide binding]; other site
1225522004350	active site
1225522004351	aconitate hydratase; Validated; Region: PRK09277
1225522004352	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1225522004353	substrate binding site [chemical binding]; other site
1225522004354	ligand binding site [chemical binding]; other site
1225522004355	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1225522004356	substrate binding site [chemical binding]; other site
1225522004357	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1225522004358	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
1225522004359	substrate binding site [chemical binding]; other site
1225522004360	putative dimerization interface [polypeptide binding]; other site
1225522004361	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1225522004362	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1225522004363	active site
1225522004364	interdomain interaction site; other site
1225522004365	putative metal-binding site [ion binding]; other site
1225522004366	nucleotide binding site [chemical binding]; other site
1225522004367	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1225522004368	domain I; other site
1225522004369	DNA binding groove [nucleotide binding]
1225522004370	phosphate binding site [ion binding]; other site
1225522004371	domain II; other site
1225522004372	domain III; other site
1225522004373	nucleotide binding site [chemical binding]; other site
1225522004374	catalytic site [active]
1225522004375	domain IV; other site
1225522004376	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1225522004377	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1225522004378	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1225522004379	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1225522004380	hypothetical protein; Provisional; Region: PRK11037
1225522004381	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1225522004382	putative inner membrane peptidase; Provisional; Region: PRK11778
1225522004383	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1225522004384	tandem repeat interface [polypeptide binding]; other site
1225522004385	oligomer interface [polypeptide binding]; other site
1225522004386	active site residues [active]
1225522004387	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1225522004388	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
1225522004389	NADP binding site [chemical binding]; other site
1225522004390	homodimer interface [polypeptide binding]; other site
1225522004391	active site
1225522004392	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1225522004393	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
1225522004394	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1225522004395	homodimer interface [polypeptide binding]; other site
1225522004396	Walker A motif; other site
1225522004397	ATP binding site [chemical binding]; other site
1225522004398	hydroxycobalamin binding site [chemical binding]; other site
1225522004399	Walker B motif; other site
1225522004400	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1225522004401	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522004402	RNA binding surface [nucleotide binding]; other site
1225522004403	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1225522004404	probable active site [active]
1225522004405	hypothetical protein; Provisional; Region: PRK11630
1225522004406	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1225522004407	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1225522004408	active site
1225522004409	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1225522004410	anthranilate synthase component I; Provisional; Region: PRK13564
1225522004411	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1225522004412	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1225522004413	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
1225522004414	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1225522004415	glutamine binding [chemical binding]; other site
1225522004416	catalytic triad [active]
1225522004417	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1225522004418	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1225522004419	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1225522004420	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1225522004421	active site
1225522004422	ribulose/triose binding site [chemical binding]; other site
1225522004423	phosphate binding site [ion binding]; other site
1225522004424	substrate (anthranilate) binding pocket [chemical binding]; other site
1225522004425	product (indole) binding pocket [chemical binding]; other site
1225522004426	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1225522004427	active site
1225522004428	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1225522004429	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1225522004430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522004431	catalytic residue [active]
1225522004432	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1225522004433	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1225522004434	substrate binding site [chemical binding]; other site
1225522004435	active site
1225522004436	catalytic residues [active]
1225522004437	heterodimer interface [polypeptide binding]; other site
1225522004438	General stress protein [General function prediction only]; Region: GsiB; COG3729
1225522004439	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1225522004440	dimerization interface [polypeptide binding]; other site
1225522004441	metal binding site [ion binding]; metal-binding site
1225522004442	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1225522004443	dinuclear metal binding motif [ion binding]; other site
1225522004444	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1225522004445	dimanganese center [ion binding]; other site
1225522004446	outer membrane protein W; Provisional; Region: PRK10959
1225522004447	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1225522004448	hypothetical protein; Provisional; Region: PRK02868
1225522004449	intracellular septation protein A; Reviewed; Region: PRK00259
1225522004450	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1225522004451	transport protein TonB; Provisional; Region: PRK10819
1225522004452	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1225522004453	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1225522004454	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1225522004455	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1225522004456	putative active site [active]
1225522004457	catalytic site [active]
1225522004458	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1225522004459	putative active site [active]
1225522004460	catalytic site [active]
1225522004461	dsDNA-mimic protein; Reviewed; Region: PRK05094
1225522004462	Ion transport protein; Region: Ion_trans; pfam00520
1225522004463	Ion channel; Region: Ion_trans_2; pfam07885
1225522004464	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1225522004465	Double zinc ribbon; Region: DZR; pfam12773
1225522004466	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1225522004467	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522004468	Walker A/P-loop; other site
1225522004469	ATP binding site [chemical binding]; other site
1225522004470	Q-loop/lid; other site
1225522004471	ABC transporter signature motif; other site
1225522004472	Walker B; other site
1225522004473	D-loop; other site
1225522004474	H-loop/switch region; other site
1225522004475	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1225522004476	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1225522004477	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522004478	Walker A/P-loop; other site
1225522004479	ATP binding site [chemical binding]; other site
1225522004480	Q-loop/lid; other site
1225522004481	ABC transporter signature motif; other site
1225522004482	Walker B; other site
1225522004483	D-loop; other site
1225522004484	H-loop/switch region; other site
1225522004485	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1225522004486	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1225522004487	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1225522004488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522004489	dimer interface [polypeptide binding]; other site
1225522004490	conserved gate region; other site
1225522004491	ABC-ATPase subunit interface; other site
1225522004492	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1225522004493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522004494	dimer interface [polypeptide binding]; other site
1225522004495	conserved gate region; other site
1225522004496	putative PBP binding loops; other site
1225522004497	ABC-ATPase subunit interface; other site
1225522004498	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1225522004499	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1225522004500	peptide binding site [polypeptide binding]; other site
1225522004501	hypothetical protein; Provisional; Region: PRK11111
1225522004502	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1225522004503	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1225522004504	putative catalytic cysteine [active]
1225522004505	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1225522004506	putative active site [active]
1225522004507	metal binding site [ion binding]; metal-binding site
1225522004508	thymidine kinase; Provisional; Region: PRK04296
1225522004509	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1225522004510	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1225522004511	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1225522004512	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1225522004513	active site
1225522004514	tetramer interface; other site
1225522004515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522004516	active site
1225522004517	response regulator of RpoS; Provisional; Region: PRK10693
1225522004518	phosphorylation site [posttranslational modification]
1225522004519	intermolecular recognition site; other site
1225522004520	dimerization interface [polypeptide binding]; other site
1225522004521	hypothetical protein; Provisional; Region: PRK01617
1225522004522	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1225522004523	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1225522004524	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1225522004525	putative active site [active]
1225522004526	putative substrate binding site [chemical binding]; other site
1225522004527	putative cosubstrate binding site; other site
1225522004528	catalytic site [active]
1225522004529	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1225522004530	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1225522004531	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1225522004532	4Fe-4S binding domain; Region: Fer4; cl02805
1225522004533	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
1225522004534	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1225522004535	[4Fe-4S] binding site [ion binding]; other site
1225522004536	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1225522004537	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1225522004538	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1225522004539	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1225522004540	molybdopterin cofactor binding site; other site
1225522004541	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1225522004542	transcriptional regulator NarL; Provisional; Region: PRK10651
1225522004543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522004544	active site
1225522004545	phosphorylation site [posttranslational modification]
1225522004546	intermolecular recognition site; other site
1225522004547	dimerization interface [polypeptide binding]; other site
1225522004548	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522004549	DNA binding residues [nucleotide binding]
1225522004550	dimerization interface [polypeptide binding]; other site
1225522004551	putative invasin; Provisional; Region: PRK10177
1225522004552	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
1225522004553	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
1225522004554	cation transport regulator; Reviewed; Region: chaB; PRK09582
1225522004555	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
1225522004556	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1225522004557	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
1225522004558	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1225522004559	hypothetical protein; Provisional; Region: PRK10941
1225522004560	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1225522004561	hypothetical protein; Provisional; Region: PRK10278
1225522004562	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1225522004563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004564	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1225522004565	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1225522004566	RF-1 domain; Region: RF-1; pfam00472
1225522004567	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
1225522004568	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1225522004569	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1225522004570	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1225522004571	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1225522004572	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1225522004573	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522004574	active site
1225522004575	putative transporter; Provisional; Region: PRK11660
1225522004576	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1225522004577	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1225522004578	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1225522004579	hypothetical protein; Provisional; Region: PRK10692
1225522004580	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1225522004581	putative active site [active]
1225522004582	catalytic residue [active]
1225522004583	GTP-binding protein YchF; Reviewed; Region: PRK09601
1225522004584	YchF GTPase; Region: YchF; cd01900
1225522004585	G1 box; other site
1225522004586	GTP/Mg2+ binding site [chemical binding]; other site
1225522004587	Switch I region; other site
1225522004588	G2 box; other site
1225522004589	Switch II region; other site
1225522004590	G3 box; other site
1225522004591	G4 box; other site
1225522004592	G5 box; other site
1225522004593	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1225522004594	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
1225522004595	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
1225522004596	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1225522004597	hydrogenase 1 large subunit; Provisional; Region: PRK10170
1225522004598	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1225522004599	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
1225522004600	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1225522004601	putative substrate-binding site; other site
1225522004602	nickel binding site [ion binding]; other site
1225522004603	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
1225522004604	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
1225522004605	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
1225522004606	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
1225522004607	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1225522004608	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
1225522004609	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1225522004610	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1225522004611	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1225522004612	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1225522004613	NAD(P) binding site [chemical binding]; other site
1225522004614	trehalase; Provisional; Region: treA; PRK13271
1225522004615	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
1225522004616	hypothetical protein; Provisional; Region: PRK10457
1225522004617	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1225522004618	Flagellar regulator YcgR; Region: YcgR; pfam07317
1225522004619	PilZ domain; Region: PilZ; pfam07238
1225522004620	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
1225522004621	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1225522004622	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1225522004623	catalytic residue [active]
1225522004624	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1225522004625	dimer interface [polypeptide binding]; other site
1225522004626	catalytic triad [active]
1225522004627	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
1225522004628	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1225522004629	TrkA-C domain; Region: TrkA_C; pfam02080
1225522004630	Transporter associated domain; Region: CorC_HlyC; smart01091
1225522004631	alanine racemase; Reviewed; Region: dadX; PRK03646
1225522004632	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1225522004633	active site
1225522004634	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522004635	substrate binding site [chemical binding]; other site
1225522004636	catalytic residues [active]
1225522004637	dimer interface [polypeptide binding]; other site
1225522004638	SpoVR family protein; Provisional; Region: PRK11767
1225522004639	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1225522004640	fatty acid metabolism regulator; Provisional; Region: PRK04984
1225522004641	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522004642	DNA-binding site [nucleotide binding]; DNA binding site
1225522004643	FadR C-terminal domain; Region: FadR_C; pfam07840
1225522004644	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1225522004645	transmembrane helices; other site
1225522004646	disulfide bond formation protein B; Provisional; Region: PRK01749
1225522004647	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1225522004648	GnsA/GnsB family; Region: GnsAB; pfam08178
1225522004649	hypothetical protein; Provisional; Region: PRK05170
1225522004650	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1225522004651	hypothetical protein; Provisional; Region: PRK10691
1225522004652	YcgL domain; Region: YcgL; cl01189
1225522004653	septum formation inhibitor; Reviewed; Region: minC; PRK03511
1225522004654	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1225522004655	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1225522004656	cell division inhibitor MinD; Provisional; Region: PRK10818
1225522004657	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1225522004658	Switch I; other site
1225522004659	Switch II; other site
1225522004660	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1225522004661	ribonuclease D; Provisional; Region: PRK10829
1225522004662	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1225522004663	catalytic site [active]
1225522004664	putative active site [active]
1225522004665	putative substrate binding site [chemical binding]; other site
1225522004666	HRDC domain; Region: HRDC; cl02578
1225522004667	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1225522004668	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1225522004669	acyl-activating enzyme (AAE) consensus motif; other site
1225522004670	putative AMP binding site [chemical binding]; other site
1225522004671	putative active site [active]
1225522004672	putative CoA binding site [chemical binding]; other site
1225522004673	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
1225522004674	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1225522004675	Glycoprotease family; Region: Peptidase_M22; pfam00814
1225522004676	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1225522004677	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1225522004678	DEAD_2; Region: DEAD_2; pfam06733
1225522004679	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1225522004680	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1225522004681	homotrimer interaction site [polypeptide binding]; other site
1225522004682	putative active site [active]
1225522004683	hypothetical protein; Provisional; Region: PRK05114
1225522004684	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
1225522004685	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1225522004686	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
1225522004687	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1225522004688	putative active site [active]
1225522004689	putative CoA binding site [chemical binding]; other site
1225522004690	nudix motif; other site
1225522004691	metal binding site [ion binding]; metal-binding site
1225522004692	L-serine deaminase; Provisional; Region: PRK15023
1225522004693	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1225522004694	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1225522004695	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1225522004696	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522004697	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1225522004698	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1225522004699	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1225522004700	Transporter associated domain; Region: CorC_HlyC; smart01091
1225522004701	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1225522004702	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1225522004703	active pocket/dimerization site; other site
1225522004704	active site
1225522004705	phosphorylation site [posttranslational modification]
1225522004706	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1225522004707	active site
1225522004708	phosphorylation site [posttranslational modification]
1225522004709	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1225522004710	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
1225522004711	hypothetical protein; Provisional; Region: PRK11469
1225522004712	Domain of unknown function DUF; Region: DUF204; pfam02659
1225522004713	Domain of unknown function DUF; Region: DUF204; pfam02659
1225522004714	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1225522004715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004716	S-adenosylmethionine binding site [chemical binding]; other site
1225522004717	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1225522004718	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1225522004719	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1225522004720	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1225522004721	DNA-binding site [nucleotide binding]; DNA binding site
1225522004722	RNA-binding motif; other site
1225522004723	PhoPQ regulatory protein; Provisional; Region: PRK10299
1225522004724	YobH-like protein; Region: YobH; pfam13996
1225522004725	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
1225522004726	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522004727	dimerization interface [polypeptide binding]; other site
1225522004728	putative Zn2+ binding site [ion binding]; other site
1225522004729	putative DNA binding site [nucleotide binding]; other site
1225522004730	Bacterial transcriptional regulator; Region: IclR; pfam01614
1225522004731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522004732	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522004733	putative substrate translocation pore; other site
1225522004734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522004735	heat shock protein HtpX; Provisional; Region: PRK05457
1225522004736	carboxy-terminal protease; Provisional; Region: PRK11186
1225522004737	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1225522004738	protein binding site [polypeptide binding]; other site
1225522004739	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1225522004740	Catalytic dyad [active]
1225522004741	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1225522004742	ProP expression regulator; Provisional; Region: PRK04950
1225522004743	ProQ/FINO family; Region: ProQ; pfam04352
1225522004744	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1225522004745	GAF domain; Region: GAF_2; pfam13185
1225522004746	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1225522004747	Paraquat-inducible protein A; Region: PqiA; pfam04403
1225522004748	Paraquat-inducible protein A; Region: PqiA; pfam04403
1225522004749	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1225522004750	mce related protein; Region: MCE; pfam02470
1225522004751	mce related protein; Region: MCE; pfam02470
1225522004752	mce related protein; Region: MCE; pfam02470
1225522004753	mce related protein; Region: MCE; pfam02470
1225522004754	mce related protein; Region: MCE; pfam02470
1225522004755	mce related protein; Region: MCE; pfam02470
1225522004756	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1225522004757	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1225522004758	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1225522004759	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
1225522004760	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
1225522004761	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
1225522004762	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1225522004763	type III secretion protein SopE2; Provisional; Region: PRK15280
1225522004764	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
1225522004765	SopE GEF domain; Region: SopE_GEF; pfam07487
1225522004766	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
1225522004767	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1225522004768	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1225522004769	EamA-like transporter family; Region: EamA; pfam00892
1225522004770	EamA-like transporter family; Region: EamA; pfam00892
1225522004771	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
1225522004772	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1225522004773	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
1225522004774	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
1225522004775	ADP-ribose binding site [chemical binding]; other site
1225522004776	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
1225522004777	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
1225522004778	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
1225522004779	Fibronectin type III protein; Region: DUF3672; pfam12421
1225522004780	Phage-related protein, tail component [Function unknown]; Region: COG4733
1225522004781	Putative phage tail protein; Region: Phage-tail_3; pfam13550
1225522004782	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1225522004783	Interdomain contacts; other site
1225522004784	Cytokine receptor motif; other site
1225522004785	Phage-related protein, tail component [Function unknown]; Region: COG4723
1225522004786	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
1225522004787	MPN+ (JAMM) motif; other site
1225522004788	Zinc-binding site [ion binding]; other site
1225522004789	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1225522004790	NlpC/P60 family; Region: NLPC_P60; cl17555
1225522004791	Phage-related protein [Function unknown]; Region: gp18; COG4672
1225522004792	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891
1225522004793	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1225522004794	active site
1225522004795	Cu2+ binding site [ion binding]; other site
1225522004796	Zn2+ binding site [ion binding]; other site
1225522004797	P-class dimer interface [polypeptide binding]; other site
1225522004798	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1225522004799	Phage-related protein [Function unknown]; Region: COG4718
1225522004800	Phage-related minor tail protein [Function unknown]; Region: COG5281
1225522004801	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
1225522004802	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
1225522004803	Minor tail protein T; Region: Phage_tail_T; cl05636
1225522004804	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
1225522004805	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1225522004806	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
1225522004807	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
1225522004808	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
1225522004809	Uncharacterized conserved protein [Function unknown]; Region: COG5471
1225522004810	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1225522004811	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1225522004812	oligomer interface [polypeptide binding]; other site
1225522004813	active site residues [active]
1225522004814	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
1225522004815	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
1225522004816	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
1225522004817	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
1225522004818	Domain of unknown function (DUF1859); Region: DUF1859; pfam08948
1225522004819	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
1225522004820	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
1225522004821	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1225522004822	catalytic residues [active]
1225522004823	phage holin, lambda family; Region: holin_lambda; TIGR01594
1225522004824	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
1225522004825	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
1225522004826	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
1225522004827	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1225522004828	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1225522004829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1225522004830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522004831	metal binding site [ion binding]; metal-binding site
1225522004832	active site
1225522004833	I-site; other site
1225522004834	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
1225522004835	Replication protein P; Region: Phage_lambda_P; pfam06992
1225522004836	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
1225522004837	primosomal protein DnaI; Provisional; Region: PRK02854
1225522004838	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
1225522004839	transcriptional repressor DicA; Reviewed; Region: PRK09706
1225522004840	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
1225522004841	exonuclease VIII; Reviewed; Region: PRK09709
1225522004842	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
1225522004843	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
1225522004844	recombination and repair protein RecT; Reviewed; Region: recT; PRK09846
1225522004845	hypothetical protein; Provisional; Region: PRK09750
1225522004846	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
1225522004847	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1225522004848	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
1225522004849	dimer interface [polypeptide binding]; other site
1225522004850	active site
1225522004851	Int/Topo IB signature motif; other site
1225522004852	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
1225522004853	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1225522004854	hypothetical protein; Provisional; Region: PRK10301
1225522004855	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
1225522004856	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1225522004857	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
1225522004858	exodeoxyribonuclease X; Provisional; Region: PRK07983
1225522004859	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1225522004860	active site
1225522004861	catalytic site [active]
1225522004862	substrate binding site [chemical binding]; other site
1225522004863	protease 2; Provisional; Region: PRK10115
1225522004864	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1225522004865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
1225522004866	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1225522004867	putative metal binding site [ion binding]; other site
1225522004868	hypothetical protein; Provisional; Region: PRK13680
1225522004869	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
1225522004870	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1225522004871	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1225522004872	ATP-grasp domain; Region: ATP-grasp; pfam02222
1225522004873	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1225522004874	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1225522004875	active site
1225522004876	intersubunit interface [polypeptide binding]; other site
1225522004877	catalytic residue [active]
1225522004878	phosphogluconate dehydratase; Validated; Region: PRK09054
1225522004879	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1225522004880	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1225522004881	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1225522004882	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1225522004883	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1225522004884	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1225522004885	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1225522004886	putative active site [active]
1225522004887	pyruvate kinase; Provisional; Region: PRK05826
1225522004888	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1225522004889	domain interfaces; other site
1225522004890	active site
1225522004891	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1225522004892	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1225522004893	putative acyl-acceptor binding pocket; other site
1225522004894	putative peptidase; Provisional; Region: PRK11649
1225522004895	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1225522004896	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522004897	Peptidase family M23; Region: Peptidase_M23; pfam01551
1225522004898	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
1225522004899	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1225522004900	metal binding site [ion binding]; metal-binding site
1225522004901	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1225522004902	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1225522004903	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1225522004904	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522004905	ABC-ATPase subunit  interface; other site
1225522004906	dimer interface [polypeptide binding]; other site
1225522004907	putative PBP binding regions; other site
1225522004908	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1225522004909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522004910	Walker A motif; other site
1225522004911	ATP binding site [chemical binding]; other site
1225522004912	Walker B motif; other site
1225522004913	arginine finger; other site
1225522004914	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1225522004915	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1225522004916	RuvA N terminal domain; Region: RuvA_N; pfam01330
1225522004917	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1225522004918	hypothetical protein; Provisional; Region: PRK11470
1225522004919	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1225522004920	active site
1225522004921	putative DNA-binding cleft [nucleotide binding]; other site
1225522004922	dimer interface [polypeptide binding]; other site
1225522004923	hypothetical protein; Validated; Region: PRK00110
1225522004924	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1225522004925	nudix motif; other site
1225522004926	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1225522004927	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1225522004928	dimer interface [polypeptide binding]; other site
1225522004929	anticodon binding site; other site
1225522004930	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1225522004931	homodimer interface [polypeptide binding]; other site
1225522004932	motif 1; other site
1225522004933	active site
1225522004934	motif 2; other site
1225522004935	GAD domain; Region: GAD; pfam02938
1225522004936	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1225522004937	active site
1225522004938	motif 3; other site
1225522004939	hypothetical protein; Provisional; Region: PRK10302
1225522004940	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
1225522004941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004942	S-adenosylmethionine binding site [chemical binding]; other site
1225522004943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004944	S-adenosylmethionine binding site [chemical binding]; other site
1225522004945	copper homeostasis protein CutC; Provisional; Region: PRK11572
1225522004946	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
1225522004947	putative metal binding site [ion binding]; other site
1225522004948	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1225522004949	arginyl-tRNA synthetase; Region: argS; TIGR00456
1225522004950	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1225522004951	active site
1225522004952	HIGH motif; other site
1225522004953	KMSK motif region; other site
1225522004954	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1225522004955	tRNA binding surface [nucleotide binding]; other site
1225522004956	anticodon binding site; other site
1225522004957	penicillin-binding protein 2; Provisional; Region: PRK10795
1225522004958	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1225522004959	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1225522004960	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1225522004961	Flagellar protein FlhE; Region: FlhE; pfam06366
1225522004962	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1225522004963	FHIPEP family; Region: FHIPEP; pfam00771
1225522004964	chemotaxis regulator CheZ; Provisional; Region: PRK11166
1225522004965	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1225522004966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522004967	active site
1225522004968	phosphorylation site [posttranslational modification]
1225522004969	intermolecular recognition site; other site
1225522004970	dimerization interface [polypeptide binding]; other site
1225522004971	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1225522004972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522004973	active site
1225522004974	phosphorylation site [posttranslational modification]
1225522004975	intermolecular recognition site; other site
1225522004976	dimerization interface [polypeptide binding]; other site
1225522004977	CheB methylesterase; Region: CheB_methylest; pfam01339
1225522004978	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
1225522004979	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1225522004980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522004981	S-adenosylmethionine binding site [chemical binding]; other site
1225522004982	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
1225522004983	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1225522004984	dimer interface [polypeptide binding]; other site
1225522004985	ligand binding site [chemical binding]; other site
1225522004986	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522004987	dimerization interface [polypeptide binding]; other site
1225522004988	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522004989	dimer interface [polypeptide binding]; other site
1225522004990	putative CheW interface [polypeptide binding]; other site
1225522004991	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1225522004992	putative CheA interaction surface; other site
1225522004993	chemotaxis protein CheA; Provisional; Region: PRK10547
1225522004994	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1225522004995	putative binding surface; other site
1225522004996	active site
1225522004997	CheY binding; Region: CheY-binding; pfam09078
1225522004998	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1225522004999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522005000	ATP binding site [chemical binding]; other site
1225522005001	Mg2+ binding site [ion binding]; other site
1225522005002	G-X-G motif; other site
1225522005003	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1225522005004	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1225522005005	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1225522005006	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1225522005007	ligand binding site [chemical binding]; other site
1225522005008	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1225522005009	flagellar motor protein MotA; Validated; Region: PRK09110
1225522005010	transcriptional activator FlhC; Provisional; Region: PRK12722
1225522005011	transcriptional activator FlhD; Provisional; Region: PRK02909
1225522005012	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1225522005013	Ligand Binding Site [chemical binding]; other site
1225522005014	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1225522005015	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1225522005016	active site
1225522005017	homotetramer interface [polypeptide binding]; other site
1225522005018	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
1225522005019	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1225522005020	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1225522005021	DJ-1 family protein; Region: not_thiJ; TIGR01383
1225522005022	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1225522005023	conserved cys residue [active]
1225522005024	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1225522005025	Ferritin-like domain; Region: Ferritin; pfam00210
1225522005026	ferroxidase diiron center [ion binding]; other site
1225522005027	hypothetical protein; Provisional; Region: PRK09273
1225522005028	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
1225522005029	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
1225522005030	YecR-like lipoprotein; Region: YecR; pfam13992
1225522005031	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1225522005032	Ferritin-like domain; Region: Ferritin; pfam00210
1225522005033	ferroxidase diiron center [ion binding]; other site
1225522005034	probable metal-binding protein; Region: matur_matur; TIGR03853
1225522005035	tyrosine transporter TyrP; Provisional; Region: PRK15132
1225522005036	aromatic amino acid transport protein; Region: araaP; TIGR00837
1225522005037	hypothetical protein; Provisional; Region: PRK10396
1225522005038	yecA family protein; Region: ygfB_yecA; TIGR02292
1225522005039	SEC-C motif; Region: SEC-C; pfam02810
1225522005040	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
1225522005041	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1225522005042	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
1225522005043	NlpC/P60 family; Region: NLPC_P60; cl17555
1225522005044	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
1225522005045	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1225522005046	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1225522005047	GIY-YIG motif/motif A; other site
1225522005048	active site
1225522005049	catalytic site [active]
1225522005050	putative DNA binding site [nucleotide binding]; other site
1225522005051	metal binding site [ion binding]; metal-binding site
1225522005052	UvrB/uvrC motif; Region: UVR; pfam02151
1225522005053	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1225522005054	Helix-hairpin-helix motif; Region: HHH; pfam00633
1225522005055	response regulator; Provisional; Region: PRK09483
1225522005056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522005057	active site
1225522005058	phosphorylation site [posttranslational modification]
1225522005059	intermolecular recognition site; other site
1225522005060	dimerization interface [polypeptide binding]; other site
1225522005061	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522005062	DNA binding residues [nucleotide binding]
1225522005063	dimerization interface [polypeptide binding]; other site
1225522005064	hypothetical protein; Provisional; Region: PRK10613
1225522005065	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1225522005066	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1225522005067	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522005068	DNA binding residues [nucleotide binding]
1225522005069	dimerization interface [polypeptide binding]; other site
1225522005070	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
1225522005071	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1225522005072	Walker A/P-loop; other site
1225522005073	ATP binding site [chemical binding]; other site
1225522005074	Q-loop/lid; other site
1225522005075	ABC transporter signature motif; other site
1225522005076	Walker B; other site
1225522005077	D-loop; other site
1225522005078	H-loop/switch region; other site
1225522005079	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1225522005080	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522005081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005082	dimer interface [polypeptide binding]; other site
1225522005083	conserved gate region; other site
1225522005084	putative PBP binding loops; other site
1225522005085	ABC-ATPase subunit interface; other site
1225522005086	D-cysteine desulfhydrase; Validated; Region: PRK03910
1225522005087	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1225522005088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522005089	catalytic residue [active]
1225522005090	cystine transporter subunit; Provisional; Region: PRK11260
1225522005091	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522005092	substrate binding pocket [chemical binding]; other site
1225522005093	membrane-bound complex binding site; other site
1225522005094	hinge residues; other site
1225522005095	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
1225522005096	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1225522005097	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1225522005098	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1225522005099	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1225522005100	DNA binding residues [nucleotide binding]
1225522005101	flagellin; Validated; Region: PRK08026
1225522005102	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1225522005103	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1225522005104	flagellar capping protein; Reviewed; Region: fliD; PRK08032
1225522005105	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1225522005106	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1225522005107	flagellar protein FliS; Validated; Region: fliS; PRK05685
1225522005108	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
1225522005109	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1225522005110	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1225522005111	active site
1225522005112	Na/Ca binding site [ion binding]; other site
1225522005113	catalytic site [active]
1225522005114	lipoprotein; Provisional; Region: PRK10397
1225522005115	putative inner membrane protein; Provisional; Region: PRK11099
1225522005116	Sulphur transport; Region: Sulf_transp; pfam04143
1225522005117	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
1225522005118	CPxP  motif; other site
1225522005119	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
1225522005120	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1225522005121	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1225522005122	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1225522005123	flagellar motor switch protein FliG; Region: fliG; TIGR00207
1225522005124	FliG C-terminal domain; Region: FliG_C; pfam01706
1225522005125	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1225522005126	Flagellar assembly protein FliH; Region: FliH; pfam02108
1225522005127	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
1225522005128	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1225522005129	Walker A motif/ATP binding site; other site
1225522005130	Walker B motif; other site
1225522005131	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
1225522005132	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
1225522005133	flagellar hook-length control protein; Provisional; Region: PRK10118
1225522005134	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
1225522005135	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
1225522005136	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1225522005137	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1225522005138	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
1225522005139	flagellar motor switch protein; Validated; Region: fliN; PRK05698
1225522005140	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
1225522005141	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1225522005142	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1225522005143	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1225522005144	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
1225522005145	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522005146	DNA binding residues [nucleotide binding]
1225522005147	dimerization interface [polypeptide binding]; other site
1225522005148	hypothetical protein; Provisional; Region: PRK10708
1225522005149	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
1225522005150	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
1225522005151	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522005152	active site
1225522005153	motif I; other site
1225522005154	motif II; other site
1225522005155	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
1225522005156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522005157	metal binding site [ion binding]; metal-binding site
1225522005158	active site
1225522005159	I-site; other site
1225522005160	Uncharacterized small protein [Function unknown]; Region: COG5475
1225522005161	hypothetical protein; Provisional; Region: PRK10062
1225522005162	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1225522005163	EamA-like transporter family; Region: EamA; pfam00892
1225522005164	EamA-like transporter family; Region: EamA; pfam00892
1225522005165	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
1225522005166	additional DNA contacts [nucleotide binding]; other site
1225522005167	mismatch recognition site; other site
1225522005168	active site
1225522005169	zinc binding site [ion binding]; other site
1225522005170	DNA intercalation site [nucleotide binding]; other site
1225522005171	DNA cytosine methylase; Provisional; Region: PRK10458
1225522005172	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1225522005173	cofactor binding site; other site
1225522005174	DNA binding site [nucleotide binding]
1225522005175	substrate interaction site [chemical binding]; other site
1225522005176	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1225522005177	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1225522005178	Zn2+ binding site [ion binding]; other site
1225522005179	Mg2+ binding site [ion binding]; other site
1225522005180	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1225522005181	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1225522005182	trimer interface [polypeptide binding]; other site
1225522005183	eyelet of channel; other site
1225522005184	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1225522005185	DNA-binding site [nucleotide binding]; DNA binding site
1225522005186	RNA-binding motif; other site
1225522005187	dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965
1225522005188	Integrase core domain; Region: rve; pfam00665
1225522005189	Integrase core domain; Region: rve_2; pfam13333
1225522005190	HTH-like domain; Region: HTH_21; pfam13276
1225522005191	Transposase; Region: HTH_Tnp_1; cl17663
1225522005192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1225522005193	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522005194	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522005195	Sel1-like repeats; Region: SEL1; smart00671
1225522005196	PAAR motif; Region: PAAR_motif; cl15808
1225522005197	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1225522005198	RHS Repeat; Region: RHS_repeat; pfam05593
1225522005199	RHS Repeat; Region: RHS_repeat; pfam05593
1225522005200	RHS Repeat; Region: RHS_repeat; pfam05593
1225522005201	RHS Repeat; Region: RHS_repeat; cl11982
1225522005202	RHS Repeat; Region: RHS_repeat; pfam05593
1225522005203	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1225522005204	RHS Repeat; Region: RHS_repeat; pfam05593
1225522005205	RHS Repeat; Region: RHS_repeat; pfam05593
1225522005206	RHS Repeat; Region: RHS_repeat; cl11982
1225522005207	RHS protein; Region: RHS; pfam03527
1225522005208	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1225522005209	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1225522005210	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1225522005211	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1225522005212	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1225522005213	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1225522005214	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1225522005215	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1225522005216	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1225522005217	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1225522005218	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1225522005219	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1225522005220	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1225522005221	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
1225522005222	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
1225522005223	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
1225522005224	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
1225522005225	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1225522005226	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
1225522005227	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1225522005228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522005229	Walker A motif; other site
1225522005230	ATP binding site [chemical binding]; other site
1225522005231	Walker B motif; other site
1225522005232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522005233	Walker A motif; other site
1225522005234	ATP binding site [chemical binding]; other site
1225522005235	Walker B motif; other site
1225522005236	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1225522005237	type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360
1225522005238	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1225522005239	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1225522005240	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
1225522005241	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1225522005242	AAA domain; Region: AAA_17; pfam13207
1225522005243	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1225522005244	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1225522005245	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
1225522005246	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1225522005247	ImpA domain protein; Region: DUF3702; pfam12486
1225522005248	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1225522005249	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522005250	YCII-related domain; Region: YCII; cl00999
1225522005251	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1225522005252	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1225522005253	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1225522005254	putative sialic acid transporter; Provisional; Region: PRK12307
1225522005255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522005256	putative substrate translocation pore; other site
1225522005257	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
1225522005258	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
1225522005259	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
1225522005260	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1225522005261	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1225522005262	putative active site cavity [active]
1225522005263	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1225522005264	Na binding site [ion binding]; other site
1225522005265	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1225522005266	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1225522005267	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1225522005268	putative active site [active]
1225522005269	hypothetical protein; Provisional; Region: PRK10536
1225522005270	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1225522005271	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1225522005272	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1225522005273	Na binding site [ion binding]; other site
1225522005274	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
1225522005275	Predicted transcriptional regulator [Transcription]; Region: COG3905
1225522005276	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1225522005277	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1225522005278	Glutamate binding site [chemical binding]; other site
1225522005279	NAD binding site [chemical binding]; other site
1225522005280	catalytic residues [active]
1225522005281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
1225522005282	General stress protein [General function prediction only]; Region: GsiB; COG3729
1225522005283	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
1225522005284	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1225522005285	hypothetical protein; Provisional; Region: PRK10174
1225522005286	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
1225522005287	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1225522005288	catalytic core [active]
1225522005289	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1225522005290	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1225522005291	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1225522005292	catalytic residues [active]
1225522005293	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
1225522005294	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1225522005295	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1225522005296	catalytic residues [active]
1225522005297	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
1225522005298	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1225522005299	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1225522005300	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1225522005301	DsbD alpha interface [polypeptide binding]; other site
1225522005302	catalytic residues [active]
1225522005303	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1225522005304	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1225522005305	HSP70 interaction site [polypeptide binding]; other site
1225522005306	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1225522005307	substrate binding site [polypeptide binding]; other site
1225522005308	dimer interface [polypeptide binding]; other site
1225522005309	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
1225522005310	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
1225522005311	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1225522005312	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1225522005313	Cupin domain; Region: Cupin_2; pfam07883
1225522005314	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522005315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522005316	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1225522005317	putative substrate translocation pore; other site
1225522005318	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1225522005319	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
1225522005320	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1225522005321	putative substrate binding pocket [chemical binding]; other site
1225522005322	trimer interface [polypeptide binding]; other site
1225522005323	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
1225522005324	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1225522005325	putative active site [active]
1225522005326	putative metal binding site [ion binding]; other site
1225522005327	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1225522005328	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1225522005329	NAD binding site [chemical binding]; other site
1225522005330	catalytic residues [active]
1225522005331	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
1225522005332	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1225522005333	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1225522005334	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
1225522005335	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1225522005336	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
1225522005337	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1225522005338	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
1225522005339	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1225522005340	active site
1225522005341	homotetramer interface [polypeptide binding]; other site
1225522005342	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
1225522005343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522005344	active site
1225522005345	phosphorylation site [posttranslational modification]
1225522005346	intermolecular recognition site; other site
1225522005347	dimerization interface [polypeptide binding]; other site
1225522005348	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522005349	DNA binding site [nucleotide binding]
1225522005350	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1225522005351	HAMP domain; Region: HAMP; pfam00672
1225522005352	dimerization interface [polypeptide binding]; other site
1225522005353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522005354	dimer interface [polypeptide binding]; other site
1225522005355	phosphorylation site [posttranslational modification]
1225522005356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522005357	ATP binding site [chemical binding]; other site
1225522005358	Mg2+ binding site [ion binding]; other site
1225522005359	G-X-G motif; other site
1225522005360	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
1225522005361	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
1225522005362	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
1225522005363	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
1225522005364	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
1225522005365	secreted effector protein PipB; Provisional; Region: PRK15197
1225522005366	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522005367	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522005368	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522005369	PipA protein; Region: PipA; pfam07108
1225522005370	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1225522005371	YccA-like proteins; Region: YccA_like; cd10433
1225522005372	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1225522005373	sulfur transfer protein TusE; Provisional; Region: PRK11508
1225522005374	acylphosphatase; Provisional; Region: PRK14426
1225522005375	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522005376	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522005377	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1225522005378	substrate binding site [chemical binding]; other site
1225522005379	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
1225522005380	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1225522005381	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1225522005382	putative RNA binding site [nucleotide binding]; other site
1225522005383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522005384	S-adenosylmethionine binding site [chemical binding]; other site
1225522005385	heat shock protein HspQ; Provisional; Region: PRK14129
1225522005386	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1225522005387	hypothetical protein; Provisional; Region: PRK03641
1225522005388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
1225522005389	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1225522005390	active site
1225522005391	dimer interfaces [polypeptide binding]; other site
1225522005392	catalytic residues [active]
1225522005393	DNA helicase IV; Provisional; Region: helD; PRK11054
1225522005394	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
1225522005395	Part of AAA domain; Region: AAA_19; pfam13245
1225522005396	Family description; Region: UvrD_C_2; pfam13538
1225522005397	Predicted membrane protein [Function unknown]; Region: COG3304
1225522005398	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1225522005399	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1225522005400	TIGR01666 family membrane protein; Region: YCCS
1225522005401	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1225522005402	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1225522005403	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
1225522005404	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1225522005405	cell division inhibitor SulA; Region: sula; TIGR00623
1225522005406	outer membrane protein A; Reviewed; Region: PRK10808
1225522005407	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1225522005408	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1225522005409	ligand binding site [chemical binding]; other site
1225522005410	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
1225522005411	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
1225522005412	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1225522005413	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1225522005414	active site 1 [active]
1225522005415	dimer interface [polypeptide binding]; other site
1225522005416	active site 2 [active]
1225522005417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1225522005418	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1225522005419	paraquat-inducible protein B; Provisional; Region: PRK10807
1225522005420	mce related protein; Region: MCE; pfam02470
1225522005421	mce related protein; Region: MCE; pfam02470
1225522005422	mce related protein; Region: MCE; pfam02470
1225522005423	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
1225522005424	Paraquat-inducible protein A; Region: PqiA; pfam04403
1225522005425	Paraquat-inducible protein A; Region: PqiA; pfam04403
1225522005426	ABC transporter ATPase component; Reviewed; Region: PRK11147
1225522005427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005428	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005429	Walker A/P-loop; other site
1225522005430	Walker A/P-loop; other site
1225522005431	ATP binding site [chemical binding]; other site
1225522005432	ATP binding site [chemical binding]; other site
1225522005433	Q-loop/lid; other site
1225522005434	Q-loop/lid; other site
1225522005435	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522005436	ABC transporter signature motif; other site
1225522005437	Walker B; other site
1225522005438	D-loop; other site
1225522005439	ABC transporter; Region: ABC_tran_2; pfam12848
1225522005440	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522005441	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1225522005442	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1225522005443	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1225522005444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522005445	S-adenosylmethionine binding site [chemical binding]; other site
1225522005446	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1225522005447	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1225522005448	MOSC domain; Region: MOSC; pfam03473
1225522005449	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1225522005450	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1225522005451	catalytic loop [active]
1225522005452	iron binding site [ion binding]; other site
1225522005453	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
1225522005454	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1225522005455	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1225522005456	quinone interaction residues [chemical binding]; other site
1225522005457	active site
1225522005458	catalytic residues [active]
1225522005459	FMN binding site [chemical binding]; other site
1225522005460	substrate binding site [chemical binding]; other site
1225522005461	aminopeptidase N; Provisional; Region: pepN; PRK14015
1225522005462	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1225522005463	active site
1225522005464	Zn binding site [ion binding]; other site
1225522005465	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1225522005466	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1225522005467	active site
1225522005468	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1225522005469	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1225522005470	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1225522005471	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1225522005472	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522005473	catalytic residue [active]
1225522005474	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1225522005475	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522005476	putative DNA binding site [nucleotide binding]; other site
1225522005477	putative Zn2+ binding site [ion binding]; other site
1225522005478	AsnC family; Region: AsnC_trans_reg; pfam01037
1225522005479	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1225522005480	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1225522005481	putative dimer interface [polypeptide binding]; other site
1225522005482	putative anticodon binding site; other site
1225522005483	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1225522005484	homodimer interface [polypeptide binding]; other site
1225522005485	motif 1; other site
1225522005486	motif 2; other site
1225522005487	active site
1225522005488	motif 3; other site
1225522005489	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1225522005490	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1225522005491	trimer interface [polypeptide binding]; other site
1225522005492	eyelet of channel; other site
1225522005493	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1225522005494	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522005495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522005496	homodimer interface [polypeptide binding]; other site
1225522005497	catalytic residue [active]
1225522005498	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1225522005499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1225522005500	Peptidase M15; Region: Peptidase_M15_3; cl01194
1225522005501	murein L,D-transpeptidase; Provisional; Region: PRK10594
1225522005502	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1225522005503	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1225522005504	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1225522005505	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
1225522005506	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1225522005507	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1225522005508	condesin subunit E; Provisional; Region: PRK05256
1225522005509	condesin subunit F; Provisional; Region: PRK05260
1225522005510	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1225522005511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522005512	S-adenosylmethionine binding site [chemical binding]; other site
1225522005513	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1225522005514	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1225522005515	putative active site [active]
1225522005516	hypothetical protein; Provisional; Region: PRK10593
1225522005517	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1225522005518	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1225522005519	Ligand binding site; other site
1225522005520	oligomer interface; other site
1225522005521	hypothetical protein; Provisional; Region: PRK11827
1225522005522	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1225522005523	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
1225522005524	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
1225522005525	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522005526	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1225522005527	Walker A/P-loop; other site
1225522005528	ATP binding site [chemical binding]; other site
1225522005529	Q-loop/lid; other site
1225522005530	ABC transporter signature motif; other site
1225522005531	Walker B; other site
1225522005532	D-loop; other site
1225522005533	H-loop/switch region; other site
1225522005534	ComEC family competence protein; Provisional; Region: PRK11539
1225522005535	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1225522005536	Competence protein; Region: Competence; pfam03772
1225522005537	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1225522005538	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1225522005539	IHF dimer interface [polypeptide binding]; other site
1225522005540	IHF - DNA interface [nucleotide binding]; other site
1225522005541	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1225522005542	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1225522005543	RNA binding site [nucleotide binding]; other site
1225522005544	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1225522005545	RNA binding site [nucleotide binding]; other site
1225522005546	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1225522005547	RNA binding site [nucleotide binding]; other site
1225522005548	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1225522005549	RNA binding site [nucleotide binding]; other site
1225522005550	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1225522005551	RNA binding site [nucleotide binding]; other site
1225522005552	cytidylate kinase; Provisional; Region: cmk; PRK00023
1225522005553	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1225522005554	CMP-binding site; other site
1225522005555	The sites determining sugar specificity; other site
1225522005556	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1225522005557	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1225522005558	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
1225522005559	putative active site [active]
1225522005560	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1225522005561	homodimer interface [polypeptide binding]; other site
1225522005562	substrate-cofactor binding pocket; other site
1225522005563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522005564	catalytic residue [active]
1225522005565	Predicted membrane protein [Function unknown]; Region: COG2323
1225522005566	uncharacterized domain; Region: TIGR00702
1225522005567	YcaO-like family; Region: YcaO; pfam02624
1225522005568	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1225522005569	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1225522005570	Pyruvate formate lyase 1; Region: PFL1; cd01678
1225522005571	coenzyme A binding site [chemical binding]; other site
1225522005572	active site
1225522005573	catalytic residues [active]
1225522005574	glycine loop; other site
1225522005575	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
1225522005576	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
1225522005577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522005578	FeS/SAM binding site; other site
1225522005579	inner membrane transporter YjeM; Provisional; Region: PRK15238
1225522005580	putative MFS family transporter protein; Provisional; Region: PRK03633
1225522005581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522005582	putative substrate translocation pore; other site
1225522005583	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
1225522005584	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1225522005585	4Fe-4S binding domain; Region: Fer4; pfam00037
1225522005586	seryl-tRNA synthetase; Provisional; Region: PRK05431
1225522005587	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1225522005588	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1225522005589	dimer interface [polypeptide binding]; other site
1225522005590	active site
1225522005591	motif 1; other site
1225522005592	motif 2; other site
1225522005593	motif 3; other site
1225522005594	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1225522005595	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1225522005596	DNA translocase FtsK; Provisional; Region: PRK10263
1225522005597	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1225522005598	DNA translocase FtsK; Provisional; Region: PRK10263
1225522005599	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1225522005600	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1225522005601	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1225522005602	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522005603	putative DNA binding site [nucleotide binding]; other site
1225522005604	putative Zn2+ binding site [ion binding]; other site
1225522005605	AsnC family; Region: AsnC_trans_reg; pfam01037
1225522005606	thioredoxin reductase; Provisional; Region: PRK10262
1225522005607	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522005608	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522005609	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1225522005610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522005611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005612	Walker A/P-loop; other site
1225522005613	ATP binding site [chemical binding]; other site
1225522005614	Q-loop/lid; other site
1225522005615	ABC transporter signature motif; other site
1225522005616	Walker B; other site
1225522005617	D-loop; other site
1225522005618	H-loop/switch region; other site
1225522005619	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1225522005620	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522005621	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005622	Walker A/P-loop; other site
1225522005623	ATP binding site [chemical binding]; other site
1225522005624	Q-loop/lid; other site
1225522005625	ABC transporter signature motif; other site
1225522005626	Walker B; other site
1225522005627	D-loop; other site
1225522005628	H-loop/switch region; other site
1225522005629	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1225522005630	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1225522005631	rRNA binding site [nucleotide binding]; other site
1225522005632	predicted 30S ribosome binding site; other site
1225522005633	LysR family transcriptional regulator; Provisional; Region: PRK14997
1225522005634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522005635	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1225522005636	putative effector binding pocket; other site
1225522005637	putative dimerization interface [polypeptide binding]; other site
1225522005638	Pirin-related protein [General function prediction only]; Region: COG1741
1225522005639	Pirin; Region: Pirin; pfam02678
1225522005640	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1225522005641	Isochorismatase family; Region: Isochorismatase; pfam00857
1225522005642	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1225522005643	catalytic triad [active]
1225522005644	dimer interface [polypeptide binding]; other site
1225522005645	conserved cis-peptide bond; other site
1225522005646	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1225522005647	Clp amino terminal domain; Region: Clp_N; pfam02861
1225522005648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522005649	Walker A motif; other site
1225522005650	ATP binding site [chemical binding]; other site
1225522005651	Walker B motif; other site
1225522005652	arginine finger; other site
1225522005653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522005654	Walker A motif; other site
1225522005655	ATP binding site [chemical binding]; other site
1225522005656	Walker B motif; other site
1225522005657	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1225522005658	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1225522005659	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1225522005660	DNA-binding site [nucleotide binding]; DNA binding site
1225522005661	RNA-binding motif; other site
1225522005662	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1225522005663	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1225522005664	Walker A/P-loop; other site
1225522005665	ATP binding site [chemical binding]; other site
1225522005666	Q-loop/lid; other site
1225522005667	ABC transporter signature motif; other site
1225522005668	Walker B; other site
1225522005669	D-loop; other site
1225522005670	H-loop/switch region; other site
1225522005671	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1225522005672	FtsX-like permease family; Region: FtsX; pfam02687
1225522005673	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1225522005674	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522005675	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522005676	Protein of unknown function (DUF535); Region: DUF535; pfam04393
1225522005677	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1225522005678	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1225522005679	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1225522005680	putative active site [active]
1225522005681	putative metal-binding site [ion binding]; other site
1225522005682	Predicted membrane protein [Function unknown]; Region: COG2431
1225522005683	hybrid cluster protein; Provisional; Region: PRK05290
1225522005684	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1225522005685	ACS interaction site; other site
1225522005686	CODH interaction site; other site
1225522005687	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
1225522005688	hybrid metal cluster; other site
1225522005689	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
1225522005690	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1225522005691	FAD binding pocket [chemical binding]; other site
1225522005692	FAD binding motif [chemical binding]; other site
1225522005693	phosphate binding motif [ion binding]; other site
1225522005694	beta-alpha-beta structure motif; other site
1225522005695	NAD binding pocket [chemical binding]; other site
1225522005696	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1225522005697	catalytic loop [active]
1225522005698	iron binding site [ion binding]; other site
1225522005699	pyruvate dehydrogenase; Provisional; Region: PRK09124
1225522005700	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1225522005701	PYR/PP interface [polypeptide binding]; other site
1225522005702	dimer interface [polypeptide binding]; other site
1225522005703	tetramer interface [polypeptide binding]; other site
1225522005704	TPP binding site [chemical binding]; other site
1225522005705	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1225522005706	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1225522005707	TPP-binding site [chemical binding]; other site
1225522005708	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1225522005709	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1225522005710	tetramer interface [polypeptide binding]; other site
1225522005711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522005712	catalytic residue [active]
1225522005713	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1225522005714	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
1225522005715	putative NAD(P) binding site [chemical binding]; other site
1225522005716	putative active site [active]
1225522005717	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1225522005718	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1225522005719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1225522005720	NAD(P) binding site [chemical binding]; other site
1225522005721	active site
1225522005722	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1225522005723	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1225522005724	amidase catalytic site [active]
1225522005725	Zn binding residues [ion binding]; other site
1225522005726	substrate binding site [chemical binding]; other site
1225522005727	putative lipoprotein; Provisional; Region: PRK10533
1225522005728	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
1225522005729	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005730	Walker A/P-loop; other site
1225522005731	ATP binding site [chemical binding]; other site
1225522005732	Q-loop/lid; other site
1225522005733	ABC transporter signature motif; other site
1225522005734	Walker B; other site
1225522005735	D-loop; other site
1225522005736	H-loop/switch region; other site
1225522005737	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1225522005738	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522005739	substrate binding pocket [chemical binding]; other site
1225522005740	membrane-bound complex binding site; other site
1225522005741	hinge residues; other site
1225522005742	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522005743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005744	dimer interface [polypeptide binding]; other site
1225522005745	conserved gate region; other site
1225522005746	putative PBP binding loops; other site
1225522005747	ABC-ATPase subunit interface; other site
1225522005748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005749	dimer interface [polypeptide binding]; other site
1225522005750	conserved gate region; other site
1225522005751	putative PBP binding loops; other site
1225522005752	ABC-ATPase subunit interface; other site
1225522005753	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1225522005754	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522005755	substrate binding pocket [chemical binding]; other site
1225522005756	membrane-bound complex binding site; other site
1225522005757	hinge residues; other site
1225522005758	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1225522005759	Sulfatase; Region: Sulfatase; cl17466
1225522005760	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1225522005761	active site
1225522005762	P-loop; other site
1225522005763	phosphorylation site [posttranslational modification]
1225522005764	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1225522005765	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
1225522005766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522005767	S-adenosylmethionine binding site [chemical binding]; other site
1225522005768	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
1225522005769	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1225522005770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005771	dimer interface [polypeptide binding]; other site
1225522005772	conserved gate region; other site
1225522005773	putative PBP binding loops; other site
1225522005774	ABC-ATPase subunit interface; other site
1225522005775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005776	dimer interface [polypeptide binding]; other site
1225522005777	conserved gate region; other site
1225522005778	putative PBP binding loops; other site
1225522005779	ABC-ATPase subunit interface; other site
1225522005780	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1225522005781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005782	Walker A/P-loop; other site
1225522005783	ATP binding site [chemical binding]; other site
1225522005784	Q-loop/lid; other site
1225522005785	ABC transporter signature motif; other site
1225522005786	Walker B; other site
1225522005787	D-loop; other site
1225522005788	H-loop/switch region; other site
1225522005789	TOBE domain; Region: TOBE_2; pfam08402
1225522005790	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1225522005791	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1225522005792	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1225522005793	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1225522005794	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1225522005795	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1225522005796	dimer interface [polypeptide binding]; other site
1225522005797	FMN binding site [chemical binding]; other site
1225522005798	NADPH bind site [chemical binding]; other site
1225522005799	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
1225522005800	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1225522005801	GSH binding site [chemical binding]; other site
1225522005802	catalytic residues [active]
1225522005803	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
1225522005804	putative transporter; Provisional; Region: PRK04972
1225522005805	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1225522005806	TrkA-C domain; Region: TrkA_C; pfam02080
1225522005807	TrkA-C domain; Region: TrkA_C; pfam02080
1225522005808	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1225522005809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1225522005810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522005811	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1225522005812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522005813	putative substrate translocation pore; other site
1225522005814	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522005815	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1225522005816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522005817	active site
1225522005818	motif I; other site
1225522005819	motif II; other site
1225522005820	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522005821	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
1225522005822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522005823	putative substrate translocation pore; other site
1225522005824	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1225522005825	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1225522005826	active site
1225522005827	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1225522005828	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1225522005829	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522005830	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1225522005831	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1225522005832	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1225522005833	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1225522005834	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1225522005835	putative C-terminal domain interface [polypeptide binding]; other site
1225522005836	putative GSH binding site (G-site) [chemical binding]; other site
1225522005837	putative dimer interface [polypeptide binding]; other site
1225522005838	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1225522005839	putative N-terminal domain interface [polypeptide binding]; other site
1225522005840	putative dimer interface [polypeptide binding]; other site
1225522005841	putative substrate binding pocket (H-site) [chemical binding]; other site
1225522005842	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1225522005843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522005844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522005845	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1225522005846	putative dimerization interface [polypeptide binding]; other site
1225522005847	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1225522005848	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522005849	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1225522005850	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1225522005851	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1225522005852	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1225522005853	active site
1225522005854	Uncharacterized conserved protein [Function unknown]; Region: COG3777
1225522005855	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1225522005856	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1225522005857	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1225522005858	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1225522005859	Ligand binding site [chemical binding]; other site
1225522005860	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1225522005861	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1225522005862	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
1225522005863	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1225522005864	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1225522005865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522005866	FeS/SAM binding site; other site
1225522005867	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1225522005868	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1225522005869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005870	dimer interface [polypeptide binding]; other site
1225522005871	conserved gate region; other site
1225522005872	putative PBP binding loops; other site
1225522005873	ABC-ATPase subunit interface; other site
1225522005874	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1225522005875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005876	dimer interface [polypeptide binding]; other site
1225522005877	conserved gate region; other site
1225522005878	putative PBP binding loops; other site
1225522005879	ABC-ATPase subunit interface; other site
1225522005880	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
1225522005881	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1225522005882	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1225522005883	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522005884	Walker A/P-loop; other site
1225522005885	ATP binding site [chemical binding]; other site
1225522005886	Q-loop/lid; other site
1225522005887	ABC transporter signature motif; other site
1225522005888	Walker B; other site
1225522005889	D-loop; other site
1225522005890	H-loop/switch region; other site
1225522005891	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1225522005892	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522005893	Walker A/P-loop; other site
1225522005894	ATP binding site [chemical binding]; other site
1225522005895	Q-loop/lid; other site
1225522005896	ABC transporter signature motif; other site
1225522005897	Walker B; other site
1225522005898	D-loop; other site
1225522005899	H-loop/switch region; other site
1225522005900	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1225522005901	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
1225522005902	catalytic nucleophile [active]
1225522005903	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1225522005904	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1225522005905	dimer interface [polypeptide binding]; other site
1225522005906	putative functional site; other site
1225522005907	putative MPT binding site; other site
1225522005908	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1225522005909	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1225522005910	ATP binding site [chemical binding]; other site
1225522005911	substrate interface [chemical binding]; other site
1225522005912	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1225522005913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522005914	FeS/SAM binding site; other site
1225522005915	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
1225522005916	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1225522005917	dimer interface [polypeptide binding]; other site
1225522005918	active site
1225522005919	glycine loop; other site
1225522005920	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1225522005921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522005922	active site
1225522005923	motif I; other site
1225522005924	motif II; other site
1225522005925	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522005926	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
1225522005927	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1225522005928	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522005929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522005930	Walker A/P-loop; other site
1225522005931	ATP binding site [chemical binding]; other site
1225522005932	ABC transporter signature motif; other site
1225522005933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522005934	Walker B; other site
1225522005935	ABC transporter; Region: ABC_tran_2; pfam12848
1225522005936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522005937	L,D-transpeptidase; Provisional; Region: PRK10260
1225522005938	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1225522005939	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
1225522005940	transmembrane helices; other site
1225522005941	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1225522005942	manganese transport regulator MntR; Provisional; Region: PRK11050
1225522005943	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1225522005944	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1225522005945	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1225522005946	Sulfatase; Region: Sulfatase; pfam00884
1225522005947	outer membrane protein X; Provisional; Region: ompX; PRK09408
1225522005948	threonine and homoserine efflux system; Provisional; Region: PRK10532
1225522005949	EamA-like transporter family; Region: EamA; pfam00892
1225522005950	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1225522005951	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1225522005952	dimerization interface [polypeptide binding]; other site
1225522005953	DPS ferroxidase diiron center [ion binding]; other site
1225522005954	ion pore; other site
1225522005955	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
1225522005956	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522005957	substrate binding pocket [chemical binding]; other site
1225522005958	membrane-bound complex binding site; other site
1225522005959	hinge residues; other site
1225522005960	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522005961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522005962	dimer interface [polypeptide binding]; other site
1225522005963	conserved gate region; other site
1225522005964	putative PBP binding loops; other site
1225522005965	ABC-ATPase subunit interface; other site
1225522005966	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
1225522005967	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1225522005968	Walker A/P-loop; other site
1225522005969	ATP binding site [chemical binding]; other site
1225522005970	Q-loop/lid; other site
1225522005971	ABC transporter signature motif; other site
1225522005972	Walker B; other site
1225522005973	D-loop; other site
1225522005974	H-loop/switch region; other site
1225522005975	putative mechanosensitive channel protein; Provisional; Region: PRK11465
1225522005976	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522005977	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
1225522005978	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
1225522005979	hypothetical protein; Provisional; Region: PRK11019
1225522005980	hypothetical protein; Provisional; Region: PRK10259
1225522005981	glycosyl transferase family protein; Provisional; Region: PRK08136
1225522005982	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1225522005983	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1225522005984	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1225522005985	ATP binding site [chemical binding]; other site
1225522005986	Mg++ binding site [ion binding]; other site
1225522005987	motif III; other site
1225522005988	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522005989	nucleotide binding region [chemical binding]; other site
1225522005990	ATP-binding site [chemical binding]; other site
1225522005991	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
1225522005992	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522005993	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1225522005994	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1225522005995	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1225522005996	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522005997	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1225522005998	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1225522005999	Walker A/P-loop; other site
1225522006000	ATP binding site [chemical binding]; other site
1225522006001	Q-loop/lid; other site
1225522006002	ABC transporter signature motif; other site
1225522006003	Walker B; other site
1225522006004	D-loop; other site
1225522006005	H-loop/switch region; other site
1225522006006	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1225522006007	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1225522006008	Walker A/P-loop; other site
1225522006009	ATP binding site [chemical binding]; other site
1225522006010	Q-loop/lid; other site
1225522006011	ABC transporter signature motif; other site
1225522006012	Walker B; other site
1225522006013	D-loop; other site
1225522006014	H-loop/switch region; other site
1225522006015	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1225522006016	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1225522006017	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1225522006018	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1225522006019	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
1225522006020	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
1225522006021	putative catalytic site [active]
1225522006022	putative metal binding site [ion binding]; other site
1225522006023	putative phosphate binding site [ion binding]; other site
1225522006024	cardiolipin synthase 2; Provisional; Region: PRK11263
1225522006025	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1225522006026	putative active site [active]
1225522006027	catalytic site [active]
1225522006028	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1225522006029	putative active site [active]
1225522006030	catalytic site [active]
1225522006031	Predicted integral membrane protein [Function unknown]; Region: COG0392
1225522006032	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
1225522006033	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1225522006034	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1225522006035	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1225522006036	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1225522006037	MoaE homodimer interface [polypeptide binding]; other site
1225522006038	MoaD interaction [polypeptide binding]; other site
1225522006039	active site residues [active]
1225522006040	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1225522006041	MoaE interaction surface [polypeptide binding]; other site
1225522006042	MoeB interaction surface [polypeptide binding]; other site
1225522006043	thiocarboxylated glycine; other site
1225522006044	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1225522006045	trimer interface [polypeptide binding]; other site
1225522006046	dimer interface [polypeptide binding]; other site
1225522006047	putative active site [active]
1225522006048	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1225522006049	MPT binding site; other site
1225522006050	trimer interface [polypeptide binding]; other site
1225522006051	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1225522006052	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522006053	FeS/SAM binding site; other site
1225522006054	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1225522006055	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1225522006056	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1225522006057	putative substrate binding pocket [chemical binding]; other site
1225522006058	dimer interface [polypeptide binding]; other site
1225522006059	phosphate binding site [ion binding]; other site
1225522006060	excinuclease ABC subunit B; Provisional; Region: PRK05298
1225522006061	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522006062	ATP binding site [chemical binding]; other site
1225522006063	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522006064	nucleotide binding region [chemical binding]; other site
1225522006065	ATP-binding site [chemical binding]; other site
1225522006066	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1225522006067	UvrB/uvrC motif; Region: UVR; pfam02151
1225522006068	AAA domain; Region: AAA_26; pfam13500
1225522006069	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1225522006070	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1225522006071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522006072	S-adenosylmethionine binding site [chemical binding]; other site
1225522006073	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1225522006074	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1225522006075	substrate-cofactor binding pocket; other site
1225522006076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522006077	catalytic residue [active]
1225522006078	biotin synthase; Provisional; Region: PRK15108
1225522006079	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522006080	FeS/SAM binding site; other site
1225522006081	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1225522006082	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
1225522006083	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1225522006084	inhibitor-cofactor binding pocket; inhibition site
1225522006085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522006086	catalytic residue [active]
1225522006087	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1225522006088	substrate binding site [chemical binding]; other site
1225522006089	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1225522006090	active sites [active]
1225522006091	tetramer interface [polypeptide binding]; other site
1225522006092	urocanate hydratase; Provisional; Region: PRK05414
1225522006093	histidine utilization repressor; Provisional; Region: PRK14999
1225522006094	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522006095	DNA-binding site [nucleotide binding]; DNA binding site
1225522006096	UTRA domain; Region: UTRA; pfam07702
1225522006097	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1225522006098	putative active site [active]
1225522006099	putative metal binding site [ion binding]; other site
1225522006100	imidazolonepropionase; Validated; Region: PRK09356
1225522006101	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1225522006102	active site
1225522006103	acyl-CoA thioesterase; Provisional; Region: PRK10531
1225522006104	putative pectinesterase; Region: PLN02432; cl01911
1225522006105	6-phosphogluconolactonase; Provisional; Region: PRK11028
1225522006106	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
1225522006107	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522006108	active site
1225522006109	motif I; other site
1225522006110	motif II; other site
1225522006111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522006112	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
1225522006113	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522006114	Walker A/P-loop; other site
1225522006115	ATP binding site [chemical binding]; other site
1225522006116	Q-loop/lid; other site
1225522006117	ABC transporter signature motif; other site
1225522006118	Walker B; other site
1225522006119	D-loop; other site
1225522006120	H-loop/switch region; other site
1225522006121	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1225522006122	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1225522006123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522006124	dimer interface [polypeptide binding]; other site
1225522006125	conserved gate region; other site
1225522006126	putative PBP binding loops; other site
1225522006127	ABC-ATPase subunit interface; other site
1225522006128	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1225522006129	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522006130	substrate binding pocket [chemical binding]; other site
1225522006131	membrane-bound complex binding site; other site
1225522006132	hinge residues; other site
1225522006133	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
1225522006134	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1225522006135	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1225522006136	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1225522006137	TOBE domain; Region: TOBE; pfam03459
1225522006138	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
1225522006139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522006140	Walker A/P-loop; other site
1225522006141	ATP binding site [chemical binding]; other site
1225522006142	Q-loop/lid; other site
1225522006143	ABC transporter signature motif; other site
1225522006144	Walker B; other site
1225522006145	D-loop; other site
1225522006146	H-loop/switch region; other site
1225522006147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522006148	Walker A/P-loop; other site
1225522006149	ATP binding site [chemical binding]; other site
1225522006150	Q-loop/lid; other site
1225522006151	ABC transporter signature motif; other site
1225522006152	Walker B; other site
1225522006153	D-loop; other site
1225522006154	H-loop/switch region; other site
1225522006155	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
1225522006156	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
1225522006157	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1225522006158	NAD binding site [chemical binding]; other site
1225522006159	homodimer interface [polypeptide binding]; other site
1225522006160	active site
1225522006161	substrate binding site [chemical binding]; other site
1225522006162	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
1225522006163	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1225522006164	dimer interface [polypeptide binding]; other site
1225522006165	active site
1225522006166	galactokinase; Provisional; Region: PRK05101
1225522006167	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1225522006168	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1225522006169	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1225522006170	active site
1225522006171	catalytic residues [active]
1225522006172	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1225522006173	catalytic core [active]
1225522006174	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1225522006175	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1225522006176	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1225522006177	Walker A/P-loop; other site
1225522006178	ATP binding site [chemical binding]; other site
1225522006179	Q-loop/lid; other site
1225522006180	ABC transporter signature motif; other site
1225522006181	Walker B; other site
1225522006182	D-loop; other site
1225522006183	H-loop/switch region; other site
1225522006184	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1225522006185	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522006186	dimer interface [polypeptide binding]; other site
1225522006187	putative PBP binding regions; other site
1225522006188	ABC-ATPase subunit  interface; other site
1225522006189	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
1225522006190	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
1225522006191	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
1225522006192	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1225522006193	active site
1225522006194	catalytic residues [active]
1225522006195	metal binding site [ion binding]; metal-binding site
1225522006196	homodimer binding site [polypeptide binding]; other site
1225522006197	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1225522006198	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1225522006199	transmembrane helices; other site
1225522006200	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522006201	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522006202	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1225522006203	dimerization interface [polypeptide binding]; other site
1225522006204	fumarate hydratase; Provisional; Region: PRK06246
1225522006205	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
1225522006206	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1225522006207	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1225522006208	YbgS-like protein; Region: YbgS; pfam13985
1225522006209	zinc transporter ZitB; Provisional; Region: PRK03557
1225522006210	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
1225522006211	quinolinate synthetase; Provisional; Region: PRK09375
1225522006212	tol-pal system protein YbgF; Provisional; Region: PRK10803
1225522006213	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1225522006214	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1225522006215	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1225522006216	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1225522006217	ligand binding site [chemical binding]; other site
1225522006218	translocation protein TolB; Provisional; Region: tolB; PRK03629
1225522006219	TolB amino-terminal domain; Region: TolB_N; pfam04052
1225522006220	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1225522006221	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1225522006222	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1225522006223	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1225522006224	TolA C-terminal; Region: TolA; pfam06519
1225522006225	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1225522006226	colicin uptake protein TolR; Provisional; Region: PRK11024
1225522006227	colicin uptake protein TolQ; Provisional; Region: PRK10801
1225522006228	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1225522006229	active site
1225522006230	hypothetical protein; Provisional; Region: PRK10588
1225522006231	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
1225522006232	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
1225522006233	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1225522006234	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1225522006235	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1225522006236	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1225522006237	CoA binding domain; Region: CoA_binding; smart00881
1225522006238	CoA-ligase; Region: Ligase_CoA; pfam00549
1225522006239	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1225522006240	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1225522006241	CoA-ligase; Region: Ligase_CoA; pfam00549
1225522006242	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1225522006243	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1225522006244	E3 interaction surface; other site
1225522006245	lipoyl attachment site [posttranslational modification]; other site
1225522006246	e3 binding domain; Region: E3_binding; pfam02817
1225522006247	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1225522006248	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1225522006249	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1225522006250	TPP-binding site [chemical binding]; other site
1225522006251	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1225522006252	dimer interface [polypeptide binding]; other site
1225522006253	PYR/PP interface [polypeptide binding]; other site
1225522006254	TPP binding site [chemical binding]; other site
1225522006255	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1225522006256	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1225522006257	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
1225522006258	L-aspartate oxidase; Provisional; Region: PRK06175
1225522006259	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1225522006260	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1225522006261	SdhC subunit interface [polypeptide binding]; other site
1225522006262	proximal heme binding site [chemical binding]; other site
1225522006263	cardiolipin binding site; other site
1225522006264	Iron-sulfur protein interface; other site
1225522006265	proximal quinone binding site [chemical binding]; other site
1225522006266	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1225522006267	Iron-sulfur protein interface; other site
1225522006268	proximal quinone binding site [chemical binding]; other site
1225522006269	SdhD (CybS) interface [polypeptide binding]; other site
1225522006270	proximal heme binding site [chemical binding]; other site
1225522006271	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1225522006272	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1225522006273	dimer interface [polypeptide binding]; other site
1225522006274	active site
1225522006275	citrylCoA binding site [chemical binding]; other site
1225522006276	NADH binding [chemical binding]; other site
1225522006277	cationic pore residues; other site
1225522006278	oxalacetate/citrate binding site [chemical binding]; other site
1225522006279	coenzyme A binding site [chemical binding]; other site
1225522006280	catalytic triad [active]
1225522006281	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1225522006282	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1225522006283	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1225522006284	endonuclease VIII; Provisional; Region: PRK10445
1225522006285	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
1225522006286	DNA binding site [nucleotide binding]
1225522006287	catalytic residue [active]
1225522006288	putative catalytic residues [active]
1225522006289	H2TH interface [polypeptide binding]; other site
1225522006290	intercalation triad [nucleotide binding]; other site
1225522006291	substrate specificity determining residue; other site
1225522006292	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1225522006293	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1225522006294	LamB/YcsF family protein; Provisional; Region: PRK05406
1225522006295	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1225522006296	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1225522006297	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1225522006298	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1225522006299	metal-binding protein; Provisional; Region: PRK10799
1225522006300	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1225522006301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522006302	putative substrate translocation pore; other site
1225522006303	POT family; Region: PTR2; pfam00854
1225522006304	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
1225522006305	DNA photolyase; Region: DNA_photolyase; pfam00875
1225522006306	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
1225522006307	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1225522006308	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1225522006309	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1225522006310	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1225522006311	sensor protein KdpD; Provisional; Region: PRK10490
1225522006312	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1225522006313	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1225522006314	Ligand Binding Site [chemical binding]; other site
1225522006315	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1225522006316	GAF domain; Region: GAF_3; pfam13492
1225522006317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522006318	dimer interface [polypeptide binding]; other site
1225522006319	phosphorylation site [posttranslational modification]
1225522006320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522006321	ATP binding site [chemical binding]; other site
1225522006322	Mg2+ binding site [ion binding]; other site
1225522006323	G-X-G motif; other site
1225522006324	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1225522006325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522006326	active site
1225522006327	phosphorylation site [posttranslational modification]
1225522006328	intermolecular recognition site; other site
1225522006329	dimerization interface [polypeptide binding]; other site
1225522006330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522006331	DNA binding site [nucleotide binding]
1225522006332	ornithine decarboxylase; Provisional; Region: PRK13578
1225522006333	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1225522006334	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1225522006335	homodimer interface [polypeptide binding]; other site
1225522006336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522006337	catalytic residue [active]
1225522006338	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1225522006339	putrescine transporter; Provisional; Region: potE; PRK10655
1225522006340	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1225522006341	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1225522006342	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1225522006343	active site
1225522006344	substrate binding site [chemical binding]; other site
1225522006345	metal binding site [ion binding]; metal-binding site
1225522006346	replication initiation regulator SeqA; Provisional; Region: PRK11187
1225522006347	acyl-CoA esterase; Provisional; Region: PRK10673
1225522006348	PGAP1-like protein; Region: PGAP1; pfam07819
1225522006349	LexA regulated protein; Provisional; Region: PRK11675
1225522006350	flavodoxin FldA; Validated; Region: PRK09267
1225522006351	ferric uptake regulator; Provisional; Region: fur; PRK09462
1225522006352	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1225522006353	metal binding site 2 [ion binding]; metal-binding site
1225522006354	putative DNA binding helix; other site
1225522006355	metal binding site 1 [ion binding]; metal-binding site
1225522006356	dimer interface [polypeptide binding]; other site
1225522006357	structural Zn2+ binding site [ion binding]; other site
1225522006358	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522006359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522006360	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1225522006361	putative dimerization interface [polypeptide binding]; other site
1225522006362	tricarballylate dehydrogenase; Validated; Region: PRK08274
1225522006363	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522006364	tricarballylate utilization protein B; Provisional; Region: PRK15033
1225522006365	citrate-proton symporter; Provisional; Region: PRK15075
1225522006366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522006367	putative substrate translocation pore; other site
1225522006368	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1225522006369	YbfN-like lipoprotein; Region: YbfN; pfam13982
1225522006370	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1225522006371	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1225522006372	active site
1225522006373	HIGH motif; other site
1225522006374	nucleotide binding site [chemical binding]; other site
1225522006375	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1225522006376	KMSKS motif; other site
1225522006377	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1225522006378	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
1225522006379	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1225522006380	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1225522006381	active site turn [active]
1225522006382	phosphorylation site [posttranslational modification]
1225522006383	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1225522006384	HPr interaction site; other site
1225522006385	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1225522006386	active site
1225522006387	phosphorylation site [posttranslational modification]
1225522006388	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1225522006389	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1225522006390	active site
1225522006391	trimer interface [polypeptide binding]; other site
1225522006392	allosteric site; other site
1225522006393	active site lid [active]
1225522006394	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1225522006395	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1225522006396	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1225522006397	active site
1225522006398	dimer interface [polypeptide binding]; other site
1225522006399	MarR family; Region: MarR; pfam01047
1225522006400	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1225522006401	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522006402	nucleotide binding site [chemical binding]; other site
1225522006403	UMP phosphatase; Provisional; Region: PRK10444
1225522006404	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522006405	active site
1225522006406	motif I; other site
1225522006407	motif II; other site
1225522006408	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522006409	asparagine synthetase B; Provisional; Region: asnB; PRK09431
1225522006410	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1225522006411	active site
1225522006412	dimer interface [polypeptide binding]; other site
1225522006413	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1225522006414	Ligand Binding Site [chemical binding]; other site
1225522006415	Molecular Tunnel; other site
1225522006416	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
1225522006417	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1225522006418	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1225522006419	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1225522006420	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522006421	FeS/SAM binding site; other site
1225522006422	TRAM domain; Region: TRAM; pfam01938
1225522006423	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1225522006424	PhoH-like protein; Region: PhoH; pfam02562
1225522006425	metal-binding heat shock protein; Provisional; Region: PRK00016
1225522006426	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
1225522006427	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1225522006428	Transporter associated domain; Region: CorC_HlyC; smart01091
1225522006429	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1225522006430	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1225522006431	putative active site [active]
1225522006432	catalytic triad [active]
1225522006433	putative dimer interface [polypeptide binding]; other site
1225522006434	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1225522006435	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522006436	substrate binding pocket [chemical binding]; other site
1225522006437	membrane-bound complex binding site; other site
1225522006438	hinge residues; other site
1225522006439	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522006440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522006441	dimer interface [polypeptide binding]; other site
1225522006442	conserved gate region; other site
1225522006443	putative PBP binding loops; other site
1225522006444	ABC-ATPase subunit interface; other site
1225522006445	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1225522006446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522006447	dimer interface [polypeptide binding]; other site
1225522006448	conserved gate region; other site
1225522006449	putative PBP binding loops; other site
1225522006450	ABC-ATPase subunit interface; other site
1225522006451	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1225522006452	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1225522006453	Walker A/P-loop; other site
1225522006454	ATP binding site [chemical binding]; other site
1225522006455	Q-loop/lid; other site
1225522006456	ABC transporter signature motif; other site
1225522006457	Walker B; other site
1225522006458	D-loop; other site
1225522006459	H-loop/switch region; other site
1225522006460	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1225522006461	active site
1225522006462	tetramer interface [polypeptide binding]; other site
1225522006463	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1225522006464	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
1225522006465	nucleotide binding site [chemical binding]; other site
1225522006466	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1225522006467	SBD interface [polypeptide binding]; other site
1225522006468	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
1225522006469	HSP70 interaction site [polypeptide binding]; other site
1225522006470	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
1225522006471	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1225522006472	HSP70 interaction site [polypeptide binding]; other site
1225522006473	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
1225522006474	hypothetical protein; Provisional; Region: PRK11032
1225522006475	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1225522006476	Propionate catabolism activator; Region: PrpR_N; pfam06506
1225522006477	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1225522006478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522006479	Walker A motif; other site
1225522006480	ATP binding site [chemical binding]; other site
1225522006481	Walker B motif; other site
1225522006482	arginine finger; other site
1225522006483	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1225522006484	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1225522006485	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1225522006486	HIGH motif; other site
1225522006487	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1225522006488	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1225522006489	active site
1225522006490	KMSKS motif; other site
1225522006491	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1225522006492	tRNA binding surface [nucleotide binding]; other site
1225522006493	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
1225522006494	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1225522006495	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1225522006496	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1225522006497	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1225522006498	active site
1225522006499	(T/H)XGH motif; other site
1225522006500	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
1225522006501	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522006502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522006503	homodimer interface [polypeptide binding]; other site
1225522006504	catalytic residue [active]
1225522006505	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1225522006506	catalytic core [active]
1225522006507	ribosome-associated protein; Provisional; Region: PRK11538
1225522006508	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
1225522006509	penicillin-binding protein 2; Provisional; Region: PRK10795
1225522006510	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1225522006511	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1225522006512	cell wall shape-determining protein; Provisional; Region: PRK10794
1225522006513	rare lipoprotein A; Provisional; Region: PRK10672
1225522006514	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1225522006515	Sporulation related domain; Region: SPOR; pfam05036
1225522006516	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
1225522006517	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1225522006518	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1225522006519	hypothetical protein; Provisional; Region: PRK04998
1225522006520	lipoate-protein ligase B; Provisional; Region: PRK14342
1225522006521	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
1225522006522	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522006523	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1225522006524	substrate binding pocket [chemical binding]; other site
1225522006525	dimerization interface [polypeptide binding]; other site
1225522006526	lipoyl synthase; Provisional; Region: PRK05481
1225522006527	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522006528	FeS/SAM binding site; other site
1225522006529	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
1225522006530	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1225522006531	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1225522006532	putative active site [active]
1225522006533	catalytic triad [active]
1225522006534	putative dimer interface [polypeptide binding]; other site
1225522006535	chromosome condensation membrane protein; Provisional; Region: PRK14196
1225522006536	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1225522006537	DNA-binding site [nucleotide binding]; DNA binding site
1225522006538	RNA-binding motif; other site
1225522006539	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
1225522006540	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
1225522006541	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1225522006542	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
1225522006543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522006544	active site
1225522006545	phosphorylation site [posttranslational modification]
1225522006546	intermolecular recognition site; other site
1225522006547	dimerization interface [polypeptide binding]; other site
1225522006548	Transcriptional regulator; Region: CitT; pfam12431
1225522006549	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
1225522006550	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522006551	putative active site [active]
1225522006552	heme pocket [chemical binding]; other site
1225522006553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522006554	ATP binding site [chemical binding]; other site
1225522006555	Mg2+ binding site [ion binding]; other site
1225522006556	G-X-G motif; other site
1225522006557	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
1225522006558	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1225522006559	putative active site [active]
1225522006560	(T/H)XGH motif; other site
1225522006561	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
1225522006562	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1225522006563	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1225522006564	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1225522006565	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
1225522006566	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
1225522006567	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1225522006568	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1225522006569	transmembrane helices; other site
1225522006570	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1225522006571	B1 nucleotide binding pocket [chemical binding]; other site
1225522006572	B2 nucleotide binding pocket [chemical binding]; other site
1225522006573	CAS motifs; other site
1225522006574	active site
1225522006575	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1225522006576	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1225522006577	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1225522006578	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1225522006579	NAD binding site [chemical binding]; other site
1225522006580	catalytic Zn binding site [ion binding]; other site
1225522006581	structural Zn binding site [ion binding]; other site
1225522006582	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1225522006583	Ligand Binding Site [chemical binding]; other site
1225522006584	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
1225522006585	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
1225522006586	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1225522006587	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1225522006588	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1225522006589	putative molybdopterin cofactor binding site [chemical binding]; other site
1225522006590	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
1225522006591	molybdopterin cofactor binding site; other site
1225522006592	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1225522006593	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1225522006594	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1225522006595	catalytic residue [active]
1225522006596	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1225522006597	catalytic residues [active]
1225522006598	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522006599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522006600	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
1225522006601	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1225522006602	dimer interface [polypeptide binding]; other site
1225522006603	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1225522006604	catalytic triad [active]
1225522006605	peroxidatic and resolving cysteines [active]
1225522006606	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
1225522006607	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1225522006608	dimerization domain [polypeptide binding]; other site
1225522006609	dimer interface [polypeptide binding]; other site
1225522006610	catalytic residues [active]
1225522006611	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
1225522006612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522006613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522006614	dimerization interface [polypeptide binding]; other site
1225522006615	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1225522006616	ParB-like nuclease domain; Region: ParBc; pfam02195
1225522006617	methionine aminotransferase; Validated; Region: PRK09082
1225522006618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522006619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522006620	homodimer interface [polypeptide binding]; other site
1225522006621	catalytic residue [active]
1225522006622	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1225522006623	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1225522006624	putative active site [active]
1225522006625	metal binding site [ion binding]; metal-binding site
1225522006626	Uncharacterized small protein [Function unknown]; Region: COG2879
1225522006627	carbon starvation protein A; Provisional; Region: PRK15015
1225522006628	Carbon starvation protein CstA; Region: CstA; pfam02554
1225522006629	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1225522006630	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1225522006631	CoenzymeA binding site [chemical binding]; other site
1225522006632	subunit interaction site [polypeptide binding]; other site
1225522006633	PHB binding site; other site
1225522006634	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1225522006635	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1225522006636	putative NAD(P) binding site [chemical binding]; other site
1225522006637	active site
1225522006638	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1225522006639	hydrophobic substrate binding pocket; other site
1225522006640	Isochorismatase family; Region: Isochorismatase; pfam00857
1225522006641	active site
1225522006642	conserved cis-peptide bond; other site
1225522006643	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1225522006644	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
1225522006645	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1225522006646	acyl-activating enzyme (AAE) consensus motif; other site
1225522006647	active site
1225522006648	AMP binding site [chemical binding]; other site
1225522006649	substrate binding site [chemical binding]; other site
1225522006650	isochorismate synthase EntC; Provisional; Region: PRK15016
1225522006651	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1225522006652	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
1225522006653	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1225522006654	siderophore binding site; other site
1225522006655	enterobactin exporter EntS; Provisional; Region: PRK10489
1225522006656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522006657	putative substrate translocation pore; other site
1225522006658	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1225522006659	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522006660	ABC-ATPase subunit  interface; other site
1225522006661	dimer interface [polypeptide binding]; other site
1225522006662	putative PBP binding regions; other site
1225522006663	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1225522006664	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522006665	ABC-ATPase subunit  interface; other site
1225522006666	dimer interface [polypeptide binding]; other site
1225522006667	putative PBP binding regions; other site
1225522006668	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
1225522006669	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1225522006670	Walker A/P-loop; other site
1225522006671	ATP binding site [chemical binding]; other site
1225522006672	Q-loop/lid; other site
1225522006673	ABC transporter signature motif; other site
1225522006674	Walker B; other site
1225522006675	D-loop; other site
1225522006676	H-loop/switch region; other site
1225522006677	LPS O-antigen length regulator; Provisional; Region: PRK10381
1225522006678	Chain length determinant protein; Region: Wzz; pfam02706
1225522006679	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1225522006680	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1225522006681	acyl-activating enzyme (AAE) consensus motif; other site
1225522006682	AMP binding site [chemical binding]; other site
1225522006683	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1225522006684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1225522006685	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
1225522006686	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1225522006687	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1225522006688	outer membrane receptor FepA; Provisional; Region: PRK13524
1225522006689	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522006690	N-terminal plug; other site
1225522006691	ligand-binding site [chemical binding]; other site
1225522006692	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
1225522006693	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1225522006694	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
1225522006695	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1225522006696	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
1225522006697	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1225522006698	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522006699	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1225522006700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522006701	hypothetical protein; Provisional; Region: PRK10250
1225522006702	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1225522006703	dimer interface [polypeptide binding]; other site
1225522006704	FMN binding site [chemical binding]; other site
1225522006705	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
1225522006706	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1225522006707	active site
1225522006708	oxyanion hole [active]
1225522006709	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1225522006710	catalytic triad [active]
1225522006711	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
1225522006712	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1225522006713	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522006714	phenylalanine transporter; Provisional; Region: PRK10249
1225522006715	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1225522006716	Predicted membrane protein [Function unknown]; Region: COG3059
1225522006717	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522006718	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
1225522006719	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522006720	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1225522006721	Cupin; Region: Cupin_6; pfam12852
1225522006722	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1225522006723	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522006724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522006725	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1225522006726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522006727	ATP binding site [chemical binding]; other site
1225522006728	Mg2+ binding site [ion binding]; other site
1225522006729	G-X-G motif; other site
1225522006730	Predicted membrane protein [Function unknown]; Region: COG2246
1225522006731	GtrA-like protein; Region: GtrA; pfam04138
1225522006732	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1225522006733	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1225522006734	Ligand binding site; other site
1225522006735	Putative Catalytic site; other site
1225522006736	DXD motif; other site
1225522006737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1225522006738	Transposase; Region: HTH_Tnp_1; pfam01527
1225522006739	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
1225522006740	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522006741	DNA binding residues [nucleotide binding]
1225522006742	dimerization interface [polypeptide binding]; other site
1225522006743	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1225522006744	transcriptional regulator FimZ; Provisional; Region: PRK09935
1225522006745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522006746	active site
1225522006747	phosphorylation site [posttranslational modification]
1225522006748	intermolecular recognition site; other site
1225522006749	dimerization interface [polypeptide binding]; other site
1225522006750	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522006751	DNA binding residues [nucleotide binding]
1225522006752	dimerization interface [polypeptide binding]; other site
1225522006753	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
1225522006754	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
1225522006755	outer membrane usher protein FimD; Provisional; Region: PRK15198
1225522006756	PapC N-terminal domain; Region: PapC_N; pfam13954
1225522006757	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1225522006758	PapC C-terminal domain; Region: PapC_C; pfam13953
1225522006759	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
1225522006760	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522006761	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522006762	fimbrial protein FimI; Provisional; Region: PRK15200
1225522006763	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1225522006764	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1225522006765	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1225522006766	homodimer interface [polypeptide binding]; other site
1225522006767	NADP binding site [chemical binding]; other site
1225522006768	substrate binding site [chemical binding]; other site
1225522006769	ribosome-associated protein; Provisional; Region: PRK11507
1225522006770	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1225522006771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
1225522006772	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
1225522006773	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1225522006774	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1225522006775	active site
1225522006776	HIGH motif; other site
1225522006777	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1225522006778	KMSKS motif; other site
1225522006779	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1225522006780	tRNA binding surface [nucleotide binding]; other site
1225522006781	anticodon binding site; other site
1225522006782	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1225522006783	substrate binding site [chemical binding]; other site
1225522006784	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1225522006785	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1225522006786	putative active site [active]
1225522006787	putative metal binding site [ion binding]; other site
1225522006788	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1225522006789	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1225522006790	ATP-grasp domain; Region: ATP-grasp; pfam02222
1225522006791	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
1225522006792	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1225522006793	putative substrate binding site [chemical binding]; other site
1225522006794	nucleotide binding site [chemical binding]; other site
1225522006795	nucleotide binding site [chemical binding]; other site
1225522006796	homodimer interface [polypeptide binding]; other site
1225522006797	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
1225522006798	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
1225522006799	membrane protein FdrA; Validated; Region: PRK06091
1225522006800	CoA binding domain; Region: CoA_binding; pfam02629
1225522006801	CoA-ligase; Region: Ligase_CoA; pfam00549
1225522006802	allantoate amidohydrolase; Region: AllC; TIGR03176
1225522006803	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1225522006804	active site
1225522006805	metal binding site [ion binding]; metal-binding site
1225522006806	dimer interface [polypeptide binding]; other site
1225522006807	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
1225522006808	Mif2/CENP-C like; Region: Mif2; pfam11699
1225522006809	Cupin domain; Region: Cupin_2; pfam07883
1225522006810	glycerate kinase II; Provisional; Region: PRK09932
1225522006811	allantoinase; Provisional; Region: PRK08044
1225522006812	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1225522006813	active site
1225522006814	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
1225522006815	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1225522006816	Na binding site [ion binding]; other site
1225522006817	putative substrate binding site [chemical binding]; other site
1225522006818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522006819	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522006820	putative substrate translocation pore; other site
1225522006821	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1225522006822	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1225522006823	hydroxypyruvate isomerase; Provisional; Region: PRK09997
1225522006824	glyoxylate carboligase; Provisional; Region: PRK11269
1225522006825	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1225522006826	PYR/PP interface [polypeptide binding]; other site
1225522006827	dimer interface [polypeptide binding]; other site
1225522006828	TPP binding site [chemical binding]; other site
1225522006829	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1225522006830	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
1225522006831	TPP-binding site [chemical binding]; other site
1225522006832	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
1225522006833	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1225522006834	Bacterial transcriptional regulator; Region: IclR; pfam01614
1225522006835	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1225522006836	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1225522006837	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
1225522006838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522006839	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522006840	dimerization interface [polypeptide binding]; other site
1225522006841	Predicted ATPase [General function prediction only]; Region: COG2603
1225522006842	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
1225522006843	active site residue [active]
1225522006844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522006845	dimer interface [polypeptide binding]; other site
1225522006846	conserved gate region; other site
1225522006847	ABC-ATPase subunit interface; other site
1225522006848	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1225522006849	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1225522006850	Walker A/P-loop; other site
1225522006851	ATP binding site [chemical binding]; other site
1225522006852	Q-loop/lid; other site
1225522006853	ABC transporter signature motif; other site
1225522006854	Walker B; other site
1225522006855	D-loop; other site
1225522006856	H-loop/switch region; other site
1225522006857	NIL domain; Region: NIL; pfam09383
1225522006858	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1225522006859	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1225522006860	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1225522006861	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1225522006862	FtsX-like permease family; Region: FtsX; pfam02687
1225522006863	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
1225522006864	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1225522006865	Walker A/P-loop; other site
1225522006866	ATP binding site [chemical binding]; other site
1225522006867	Q-loop/lid; other site
1225522006868	ABC transporter signature motif; other site
1225522006869	Walker B; other site
1225522006870	D-loop; other site
1225522006871	H-loop/switch region; other site
1225522006872	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1225522006873	active site
1225522006874	catalytic triad [active]
1225522006875	oxyanion hole [active]
1225522006876	switch loop; other site
1225522006877	oxidoreductase; Provisional; Region: PRK08017
1225522006878	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1225522006879	NADP binding site [chemical binding]; other site
1225522006880	active site
1225522006881	steroid binding site; other site
1225522006882	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1225522006883	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
1225522006884	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1225522006885	Walker A/P-loop; other site
1225522006886	ATP binding site [chemical binding]; other site
1225522006887	Q-loop/lid; other site
1225522006888	ABC transporter signature motif; other site
1225522006889	Walker B; other site
1225522006890	D-loop; other site
1225522006891	H-loop/switch region; other site
1225522006892	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1225522006893	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1225522006894	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1225522006895	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
1225522006896	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1225522006897	DNA binding residues [nucleotide binding]
1225522006898	dimer interface [polypeptide binding]; other site
1225522006899	copper binding site [ion binding]; other site
1225522006900	copper exporting ATPase; Provisional; Region: copA; PRK10671
1225522006901	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1225522006902	metal-binding site [ion binding]
1225522006903	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1225522006904	metal-binding site [ion binding]
1225522006905	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1225522006906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522006907	motif II; other site
1225522006908	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1225522006909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
1225522006910	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1225522006911	putative deacylase active site [active]
1225522006912	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
1225522006913	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
1225522006914	active site
1225522006915	metal binding site [ion binding]; metal-binding site
1225522006916	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1225522006917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522006918	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522006919	putative substrate translocation pore; other site
1225522006920	putative cation:proton antiport protein; Provisional; Region: PRK10669
1225522006921	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1225522006922	TrkA-N domain; Region: TrkA_N; pfam02254
1225522006923	inosine/guanosine kinase; Provisional; Region: PRK15074
1225522006924	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522006925	ferrochelatase; Reviewed; Region: hemH; PRK00035
1225522006926	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1225522006927	C-terminal domain interface [polypeptide binding]; other site
1225522006928	active site
1225522006929	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1225522006930	active site
1225522006931	N-terminal domain interface [polypeptide binding]; other site
1225522006932	adenylate kinase; Reviewed; Region: adk; PRK00279
1225522006933	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1225522006934	AMP-binding site [chemical binding]; other site
1225522006935	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1225522006936	heat shock protein 90; Provisional; Region: PRK05218
1225522006937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522006938	ATP binding site [chemical binding]; other site
1225522006939	Mg2+ binding site [ion binding]; other site
1225522006940	G-X-G motif; other site
1225522006941	recombination protein RecR; Reviewed; Region: recR; PRK00076
1225522006942	RecR protein; Region: RecR; pfam02132
1225522006943	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1225522006944	putative active site [active]
1225522006945	putative metal-binding site [ion binding]; other site
1225522006946	tetramer interface [polypeptide binding]; other site
1225522006947	hypothetical protein; Validated; Region: PRK00153
1225522006948	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1225522006949	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522006950	Walker A motif; other site
1225522006951	ATP binding site [chemical binding]; other site
1225522006952	Walker B motif; other site
1225522006953	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1225522006954	arginine finger; other site
1225522006955	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1225522006956	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
1225522006957	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1225522006958	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522006959	active site
1225522006960	hypothetical protein; Provisional; Region: PRK10527
1225522006961	primosomal replication protein N''; Provisional; Region: PRK10093
1225522006962	hypothetical protein; Provisional; Region: PRK11038
1225522006963	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1225522006964	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1225522006965	hypothetical protein; Provisional; Region: PRK11281
1225522006966	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1225522006967	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1225522006968	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522006969	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1225522006970	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522006971	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1225522006972	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1225522006973	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522006974	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1225522006975	Protein export membrane protein; Region: SecD_SecF; cl14618
1225522006976	Protein export membrane protein; Region: SecD_SecF; cl14618
1225522006977	Hha toxicity attenuator; Provisional; Region: PRK10667
1225522006978	gene expression modulator; Provisional; Region: PRK10945
1225522006979	maltose O-acetyltransferase; Provisional; Region: PRK10092
1225522006980	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1225522006981	active site
1225522006982	substrate binding site [chemical binding]; other site
1225522006983	trimer interface [polypeptide binding]; other site
1225522006984	CoA binding site [chemical binding]; other site
1225522006985	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1225522006986	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1225522006987	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1225522006988	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1225522006989	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522006990	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1225522006991	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1225522006992	DNA binding site [nucleotide binding]
1225522006993	active site
1225522006994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
1225522006995	acyl-CoA thioesterase II; Provisional; Region: PRK10526
1225522006996	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1225522006997	active site
1225522006998	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1225522006999	catalytic triad [active]
1225522007000	dimer interface [polypeptide binding]; other site
1225522007001	ammonium transporter; Provisional; Region: PRK10666
1225522007002	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
1225522007003	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1225522007004	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
1225522007005	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522007006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007007	Walker A/P-loop; other site
1225522007008	ATP binding site [chemical binding]; other site
1225522007009	Q-loop/lid; other site
1225522007010	ABC transporter signature motif; other site
1225522007011	Walker B; other site
1225522007012	D-loop; other site
1225522007013	H-loop/switch region; other site
1225522007014	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1225522007015	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522007016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007017	Walker A/P-loop; other site
1225522007018	ATP binding site [chemical binding]; other site
1225522007019	Q-loop/lid; other site
1225522007020	ABC transporter signature motif; other site
1225522007021	Walker B; other site
1225522007022	D-loop; other site
1225522007023	H-loop/switch region; other site
1225522007024	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1225522007025	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522007026	putative DNA binding site [nucleotide binding]; other site
1225522007027	putative Zn2+ binding site [ion binding]; other site
1225522007028	AsnC family; Region: AsnC_trans_reg; pfam01037
1225522007029	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1225522007030	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1225522007031	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522007032	catalytic residue [active]
1225522007033	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
1225522007034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522007035	active site
1225522007036	motif I; other site
1225522007037	motif II; other site
1225522007038	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1225522007039	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1225522007040	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1225522007041	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1225522007042	Ligand Binding Site [chemical binding]; other site
1225522007043	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1225522007044	active site
1225522007045	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
1225522007046	periplasmic folding chaperone; Provisional; Region: PRK10788
1225522007047	SurA N-terminal domain; Region: SurA_N_3; cl07813
1225522007048	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1225522007049	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1225522007050	IHF dimer interface [polypeptide binding]; other site
1225522007051	IHF - DNA interface [nucleotide binding]; other site
1225522007052	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
1225522007053	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1225522007054	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1225522007055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007056	Walker A motif; other site
1225522007057	ATP binding site [chemical binding]; other site
1225522007058	Walker B motif; other site
1225522007059	arginine finger; other site
1225522007060	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1225522007061	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1225522007062	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1225522007063	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007064	Walker A motif; other site
1225522007065	ATP binding site [chemical binding]; other site
1225522007066	Walker B motif; other site
1225522007067	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1225522007068	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1225522007069	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1225522007070	oligomer interface [polypeptide binding]; other site
1225522007071	active site residues [active]
1225522007072	trigger factor; Provisional; Region: tig; PRK01490
1225522007073	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1225522007074	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1225522007075	transcriptional regulator BolA; Provisional; Region: PRK11628
1225522007076	hypothetical protein; Provisional; Region: PRK11627
1225522007077	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
1225522007078	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1225522007079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007080	putative substrate translocation pore; other site
1225522007081	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
1225522007082	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1225522007083	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1225522007084	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1225522007085	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1225522007086	D-pathway; other site
1225522007087	Putative ubiquinol binding site [chemical binding]; other site
1225522007088	Low-spin heme (heme b) binding site [chemical binding]; other site
1225522007089	Putative water exit pathway; other site
1225522007090	Binuclear center (heme o3/CuB) [ion binding]; other site
1225522007091	K-pathway; other site
1225522007092	Putative proton exit pathway; other site
1225522007093	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1225522007094	Subunit I/III interface [polypeptide binding]; other site
1225522007095	Subunit III/IV interface [polypeptide binding]; other site
1225522007096	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
1225522007097	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
1225522007098	UbiA prenyltransferase family; Region: UbiA; pfam01040
1225522007099	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522007100	Sel1-like repeats; Region: SEL1; smart00671
1225522007101	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522007102	Sel1-like repeats; Region: SEL1; smart00671
1225522007103	Sel1-like repeats; Region: SEL1; smart00671
1225522007104	Sel1-like repeats; Region: SEL1; smart00671
1225522007105	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522007106	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522007107	Sel1-like repeats; Region: SEL1; smart00671
1225522007108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007109	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522007110	putative substrate translocation pore; other site
1225522007111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1225522007112	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1225522007113	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1225522007114	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1225522007115	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1225522007116	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
1225522007117	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1225522007118	conserved cys residue [active]
1225522007119	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1225522007120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522007121	motif II; other site
1225522007122	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
1225522007123	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522007124	catalytic residue [active]
1225522007125	transcriptional regulator protein; Region: phnR; TIGR03337
1225522007126	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522007127	DNA-binding site [nucleotide binding]; DNA binding site
1225522007128	UTRA domain; Region: UTRA; pfam07702
1225522007129	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1225522007130	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1225522007131	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
1225522007132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007133	Walker A/P-loop; other site
1225522007134	ATP binding site [chemical binding]; other site
1225522007135	Q-loop/lid; other site
1225522007136	ABC transporter signature motif; other site
1225522007137	Walker B; other site
1225522007138	D-loop; other site
1225522007139	H-loop/switch region; other site
1225522007140	TOBE domain; Region: TOBE_2; pfam08402
1225522007141	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1225522007142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522007143	dimer interface [polypeptide binding]; other site
1225522007144	conserved gate region; other site
1225522007145	putative PBP binding loops; other site
1225522007146	ABC-ATPase subunit interface; other site
1225522007147	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1225522007148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522007149	dimer interface [polypeptide binding]; other site
1225522007150	conserved gate region; other site
1225522007151	putative PBP binding loops; other site
1225522007152	ABC-ATPase subunit interface; other site
1225522007153	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1225522007154	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1225522007155	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1225522007156	Ligand Binding Site [chemical binding]; other site
1225522007157	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1225522007158	active site residue [active]
1225522007159	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1225522007160	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1225522007161	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1225522007162	substrate binding pocket [chemical binding]; other site
1225522007163	chain length determination region; other site
1225522007164	substrate-Mg2+ binding site; other site
1225522007165	catalytic residues [active]
1225522007166	aspartate-rich region 1; other site
1225522007167	active site lid residues [active]
1225522007168	aspartate-rich region 2; other site
1225522007169	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
1225522007170	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1225522007171	TPP-binding site; other site
1225522007172	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1225522007173	PYR/PP interface [polypeptide binding]; other site
1225522007174	dimer interface [polypeptide binding]; other site
1225522007175	TPP binding site [chemical binding]; other site
1225522007176	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1225522007177	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522007178	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522007179	active site
1225522007180	catalytic tetrad [active]
1225522007181	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1225522007182	tetramer interfaces [polypeptide binding]; other site
1225522007183	binuclear metal-binding site [ion binding]; other site
1225522007184	thiamine monophosphate kinase; Provisional; Region: PRK05731
1225522007185	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1225522007186	ATP binding site [chemical binding]; other site
1225522007187	dimerization interface [polypeptide binding]; other site
1225522007188	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1225522007189	putative RNA binding site [nucleotide binding]; other site
1225522007190	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1225522007191	homopentamer interface [polypeptide binding]; other site
1225522007192	active site
1225522007193	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1225522007194	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1225522007195	catalytic motif [active]
1225522007196	Zn binding site [ion binding]; other site
1225522007197	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
1225522007198	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1225522007199	ATP cone domain; Region: ATP-cone; pfam03477
1225522007200	hypothetical protein; Provisional; Region: PRK11530
1225522007201	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
1225522007202	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
1225522007203	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1225522007204	active site
1225522007205	Predicted transcriptional regulator [Transcription]; Region: COG2378
1225522007206	HTH domain; Region: HTH_11; pfam08279
1225522007207	WYL domain; Region: WYL; pfam13280
1225522007208	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1225522007209	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1225522007210	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1225522007211	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1225522007212	Protein export membrane protein; Region: SecD_SecF; pfam02355
1225522007213	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1225522007214	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1225522007215	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1225522007216	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1225522007217	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1225522007218	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1225522007219	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
1225522007220	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1225522007221	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1225522007222	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
1225522007223	peroxidase; Provisional; Region: PRK15000
1225522007224	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1225522007225	dimer interface [polypeptide binding]; other site
1225522007226	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1225522007227	catalytic triad [active]
1225522007228	peroxidatic and resolving cysteines [active]
1225522007229	maltodextrin glucosidase; Provisional; Region: PRK10785
1225522007230	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1225522007231	homodimer interface [polypeptide binding]; other site
1225522007232	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1225522007233	active site
1225522007234	homodimer interface [polypeptide binding]; other site
1225522007235	catalytic site [active]
1225522007236	putative proline-specific permease; Provisional; Region: proY; PRK10580
1225522007237	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
1225522007238	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
1225522007239	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1225522007240	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522007241	putative active site [active]
1225522007242	heme pocket [chemical binding]; other site
1225522007243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522007244	dimer interface [polypeptide binding]; other site
1225522007245	phosphorylation site [posttranslational modification]
1225522007246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522007247	ATP binding site [chemical binding]; other site
1225522007248	Mg2+ binding site [ion binding]; other site
1225522007249	G-X-G motif; other site
1225522007250	transcriptional regulator PhoB; Provisional; Region: PRK10161
1225522007251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522007252	active site
1225522007253	phosphorylation site [posttranslational modification]
1225522007254	intermolecular recognition site; other site
1225522007255	dimerization interface [polypeptide binding]; other site
1225522007256	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522007257	DNA binding site [nucleotide binding]
1225522007258	exonuclease subunit SbcD; Provisional; Region: PRK10966
1225522007259	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1225522007260	active site
1225522007261	metal binding site [ion binding]; metal-binding site
1225522007262	DNA binding site [nucleotide binding]
1225522007263	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1225522007264	exonuclease subunit SbcC; Provisional; Region: PRK10246
1225522007265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007266	Walker A/P-loop; other site
1225522007267	ATP binding site [chemical binding]; other site
1225522007268	Q-loop/lid; other site
1225522007269	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007270	ABC transporter signature motif; other site
1225522007271	Walker B; other site
1225522007272	D-loop; other site
1225522007273	H-loop/switch region; other site
1225522007274	MFS transport protein AraJ; Provisional; Region: PRK10091
1225522007275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007276	putative substrate translocation pore; other site
1225522007277	fructokinase; Reviewed; Region: PRK09557
1225522007278	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522007279	nucleotide binding site [chemical binding]; other site
1225522007280	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
1225522007281	hypothetical protein; Provisional; Region: PRK10579
1225522007282	hypothetical protein; Provisional; Region: PRK10481
1225522007283	hypothetical protein; Provisional; Region: PRK10380
1225522007284	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1225522007285	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1225522007286	ADP binding site [chemical binding]; other site
1225522007287	magnesium binding site [ion binding]; other site
1225522007288	putative shikimate binding site; other site
1225522007289	hypothetical protein; Validated; Region: PRK00124
1225522007290	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1225522007291	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1225522007292	MASE2 domain; Region: MASE2; pfam05230
1225522007293	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1225522007294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522007295	metal binding site [ion binding]; metal-binding site
1225522007296	active site
1225522007297	I-site; other site
1225522007298	hypothetical protein; Provisional; Region: PRK11505
1225522007299	psiF repeat; Region: PsiF_repeat; pfam07769
1225522007300	psiF repeat; Region: PsiF_repeat; pfam07769
1225522007301	anti-RssB factor; Provisional; Region: PRK10244
1225522007302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007303	putative substrate translocation pore; other site
1225522007304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
1225522007305	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1225522007306	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1225522007307	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1225522007308	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1225522007309	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
1225522007310	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
1225522007311	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
1225522007312	microcin B17 transporter; Reviewed; Region: PRK11098
1225522007313	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
1225522007314	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1225522007315	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1225522007316	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1225522007317	ligand binding site [chemical binding]; other site
1225522007318	flexible hinge region; other site
1225522007319	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
1225522007320	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1225522007321	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1225522007322	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1225522007323	dimer interface [polypeptide binding]; other site
1225522007324	active site
1225522007325	Schiff base residues; other site
1225522007326	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1225522007327	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1225522007328	acyl-activating enzyme (AAE) consensus motif; other site
1225522007329	AMP binding site [chemical binding]; other site
1225522007330	active site
1225522007331	CoA binding site [chemical binding]; other site
1225522007332	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1225522007333	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1225522007334	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1225522007335	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
1225522007336	dimer interface [polypeptide binding]; other site
1225522007337	active site
1225522007338	citrylCoA binding site [chemical binding]; other site
1225522007339	oxalacetate/citrate binding site [chemical binding]; other site
1225522007340	coenzyme A binding site [chemical binding]; other site
1225522007341	catalytic triad [active]
1225522007342	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1225522007343	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1225522007344	tetramer interface [polypeptide binding]; other site
1225522007345	active site
1225522007346	Mg2+/Mn2+ binding site [ion binding]; other site
1225522007347	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
1225522007348	Propionate catabolism activator; Region: PrpR_N; pfam06506
1225522007349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007350	Walker A motif; other site
1225522007351	ATP binding site [chemical binding]; other site
1225522007352	Walker B motif; other site
1225522007353	arginine finger; other site
1225522007354	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1225522007355	hypothetical protein; Provisional; Region: PRK09929
1225522007356	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
1225522007357	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1225522007358	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522007359	N-terminal plug; other site
1225522007360	ligand-binding site [chemical binding]; other site
1225522007361	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1225522007362	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1225522007363	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1225522007364	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1225522007365	putative sialic acid transporter; Region: 2A0112; TIGR00891
1225522007366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007367	putative substrate translocation pore; other site
1225522007368	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1225522007369	metal-binding site [ion binding]
1225522007370	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1225522007371	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1225522007372	DNA binding residues [nucleotide binding]
1225522007373	dimer interface [polypeptide binding]; other site
1225522007374	copper binding site [ion binding]; other site
1225522007375	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1225522007376	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1225522007377	metal-binding site [ion binding]
1225522007378	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1225522007379	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522007380	motif II; other site
1225522007381	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1225522007382	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522007383	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522007384	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1225522007385	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
1225522007386	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
1225522007387	DNA binding residues [nucleotide binding]
1225522007388	dimerization interface [polypeptide binding]; other site
1225522007389	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1225522007390	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1225522007391	DNA binding site [nucleotide binding]
1225522007392	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1225522007393	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522007394	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1225522007395	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522007396	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522007397	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
1225522007398	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
1225522007399	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522007400	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522007401	transcriptional activator TtdR; Provisional; Region: PRK09801
1225522007402	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522007403	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1225522007404	putative effector binding pocket; other site
1225522007405	putative dimerization interface [polypeptide binding]; other site
1225522007406	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1225522007407	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1225522007408	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1225522007409	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1225522007410	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1225522007411	substrate binding site [chemical binding]; other site
1225522007412	ligand binding site [chemical binding]; other site
1225522007413	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1225522007414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007415	putative substrate translocation pore; other site
1225522007416	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
1225522007417	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1225522007418	Transposase; Region: HTH_Tnp_1; cl17663
1225522007419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1225522007420	HTH-like domain; Region: HTH_21; pfam13276
1225522007421	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1225522007422	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1225522007423	putative catalytic cysteine [active]
1225522007424	gamma-glutamyl kinase; Provisional; Region: PRK05429
1225522007425	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1225522007426	nucleotide binding site [chemical binding]; other site
1225522007427	homotetrameric interface [polypeptide binding]; other site
1225522007428	putative phosphate binding site [ion binding]; other site
1225522007429	putative allosteric binding site; other site
1225522007430	PUA domain; Region: PUA; pfam01472
1225522007431	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
1225522007432	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
1225522007433	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522007434	active site
1225522007435	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1225522007436	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1225522007437	metal binding site [ion binding]; metal-binding site
1225522007438	dimer interface [polypeptide binding]; other site
1225522007439	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
1225522007440	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1225522007441	hypothetical protein; Reviewed; Region: PRK09588
1225522007442	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
1225522007443	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1225522007444	active site
1225522007445	DNA polymerase IV; Validated; Region: PRK02406
1225522007446	DNA binding site [nucleotide binding]
1225522007447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1225522007448	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1225522007449	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1225522007450	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1225522007451	putative active site [active]
1225522007452	putative dimer interface [polypeptide binding]; other site
1225522007453	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1225522007454	dimer interface [polypeptide binding]; other site
1225522007455	active site
1225522007456	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1225522007457	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1225522007458	active site
1225522007459	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1225522007460	C-N hydrolase family amidase; Provisional; Region: PRK10438
1225522007461	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1225522007462	putative active site [active]
1225522007463	catalytic triad [active]
1225522007464	dimer interface [polypeptide binding]; other site
1225522007465	multimer interface [polypeptide binding]; other site
1225522007466	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1225522007467	dimer interface [polypeptide binding]; other site
1225522007468	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1225522007469	PerC transcriptional activator; Region: PerC; pfam06069
1225522007470	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1225522007471	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
1225522007472	putative active site [active]
1225522007473	putative metal binding site [ion binding]; other site
1225522007474	putative pilin structural protein SafD; Provisional; Region: PRK15222
1225522007475	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
1225522007476	PapC N-terminal domain; Region: PapC_N; pfam13954
1225522007477	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1225522007478	PapC C-terminal domain; Region: PapC_C; pfam13953
1225522007479	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
1225522007480	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522007481	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522007482	Saf-pilin pilus formation protein; Region: Saf-Nte_pilin; cl09697
1225522007483	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1225522007484	Integrase core domain; Region: rve_3; pfam13683
1225522007485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007486	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1225522007487	Walker A motif; other site
1225522007488	ATP binding site [chemical binding]; other site
1225522007489	Walker B motif; other site
1225522007490	arginine finger; other site
1225522007491	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1225522007492	RHS protein; Region: RHS; pfam03527
1225522007493	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1225522007494	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1225522007495	Part of AAA domain; Region: AAA_19; pfam13245
1225522007496	AAA domain; Region: AAA_30; pfam13604
1225522007497	AAA domain; Region: AAA_12; pfam13087
1225522007498	Nuclease-related domain; Region: NERD; pfam08378
1225522007499	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1225522007500	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1225522007501	active site
1225522007502	ATP binding site [chemical binding]; other site
1225522007503	Predicted GTPase [General function prediction only]; Region: COG3596
1225522007504	YfjP GTPase; Region: YfjP; cd11383
1225522007505	G1 box; other site
1225522007506	GTP/Mg2+ binding site [chemical binding]; other site
1225522007507	Switch I region; other site
1225522007508	G2 box; other site
1225522007509	Switch II region; other site
1225522007510	G3 box; other site
1225522007511	G4 box; other site
1225522007512	G5 box; other site
1225522007513	Stage III sporulation protein D; Region: SpoIIID; cl17560
1225522007514	WYL domain; Region: WYL; cl14852
1225522007515	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
1225522007516	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
1225522007517	Domain of unknown function (DUF932); Region: DUF932; pfam06067
1225522007518	Antirestriction protein; Region: Antirestrict; pfam03230
1225522007519	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1225522007520	MPN+ (JAMM) motif; other site
1225522007521	Zinc-binding site [ion binding]; other site
1225522007522	Protein of unknown function (DUF987); Region: DUF987; pfam06174
1225522007523	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
1225522007524	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
1225522007525	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
1225522007526	Methyltransferase domain; Region: Methyltransf_27; pfam13708
1225522007527	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1225522007528	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1225522007529	active site
1225522007530	catalytic site [active]
1225522007531	substrate binding site [chemical binding]; other site
1225522007532	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1225522007533	RNA/DNA hybrid binding site [nucleotide binding]; other site
1225522007534	active site
1225522007535	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1225522007536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522007537	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
1225522007538	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1225522007539	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1225522007540	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1225522007541	catalytic residue [active]
1225522007542	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1225522007543	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522007544	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1225522007545	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522007546	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1225522007547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522007548	S-adenosylmethionine binding site [chemical binding]; other site
1225522007549	hypothetical protein; Provisional; Region: PRK05421
1225522007550	putative catalytic site [active]
1225522007551	putative metal binding site [ion binding]; other site
1225522007552	putative phosphate binding site [ion binding]; other site
1225522007553	putative catalytic site [active]
1225522007554	putative phosphate binding site [ion binding]; other site
1225522007555	putative metal binding site [ion binding]; other site
1225522007556	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1225522007557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007558	putative substrate translocation pore; other site
1225522007559	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522007560	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522007561	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
1225522007562	putative effector binding pocket; other site
1225522007563	dimerization interface [polypeptide binding]; other site
1225522007564	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522007565	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522007566	active site
1225522007567	catalytic tetrad [active]
1225522007568	protein disaggregation chaperone; Provisional; Region: PRK10865
1225522007569	Clp amino terminal domain; Region: Clp_N; pfam02861
1225522007570	Clp amino terminal domain; Region: Clp_N; pfam02861
1225522007571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007572	Walker A motif; other site
1225522007573	ATP binding site [chemical binding]; other site
1225522007574	Walker B motif; other site
1225522007575	arginine finger; other site
1225522007576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007577	Walker A motif; other site
1225522007578	ATP binding site [chemical binding]; other site
1225522007579	Walker B motif; other site
1225522007580	arginine finger; other site
1225522007581	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1225522007582	hypothetical protein; Provisional; Region: PRK10723
1225522007583	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1225522007584	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1225522007585	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522007586	RNA binding surface [nucleotide binding]; other site
1225522007587	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1225522007588	active site
1225522007589	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
1225522007590	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
1225522007591	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1225522007592	30S subunit binding site; other site
1225522007593	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
1225522007594	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
1225522007595	Prephenate dehydratase; Region: PDT; pfam00800
1225522007596	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1225522007597	putative L-Phe binding site [chemical binding]; other site
1225522007598	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1225522007599	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
1225522007600	Chorismate mutase type II; Region: CM_2; cl00693
1225522007601	prephenate dehydrogenase; Validated; Region: PRK08507
1225522007602	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1225522007603	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1225522007604	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1225522007605	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
1225522007606	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522007607	metal binding site [ion binding]; metal-binding site
1225522007608	active site
1225522007609	I-site; other site
1225522007610	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1225522007611	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1225522007612	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1225522007613	RimM N-terminal domain; Region: RimM; pfam01782
1225522007614	PRC-barrel domain; Region: PRC; pfam05239
1225522007615	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1225522007616	signal recognition particle protein; Provisional; Region: PRK10867
1225522007617	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1225522007618	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1225522007619	P loop; other site
1225522007620	GTP binding site [chemical binding]; other site
1225522007621	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1225522007622	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1225522007623	hypothetical protein; Provisional; Region: PRK11573
1225522007624	Domain of unknown function DUF21; Region: DUF21; pfam01595
1225522007625	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1225522007626	Transporter associated domain; Region: CorC_HlyC; smart01091
1225522007627	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1225522007628	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1225522007629	dimer interface [polypeptide binding]; other site
1225522007630	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1225522007631	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
1225522007632	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1225522007633	recombination and repair protein; Provisional; Region: PRK10869
1225522007634	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1225522007635	Walker A/P-loop; other site
1225522007636	ATP binding site [chemical binding]; other site
1225522007637	Q-loop/lid; other site
1225522007638	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1225522007639	ABC transporter signature motif; other site
1225522007640	Walker B; other site
1225522007641	D-loop; other site
1225522007642	H-loop/switch region; other site
1225522007643	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
1225522007644	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1225522007645	hypothetical protein; Validated; Region: PRK01777
1225522007646	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1225522007647	putative coenzyme Q binding site [chemical binding]; other site
1225522007648	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1225522007649	SmpB-tmRNA interface; other site
1225522007650	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1225522007651	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1225522007652	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522007653	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1225522007654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1225522007655	Integrase core domain; Region: rve; pfam00665
1225522007656	Integrase core domain; Region: rve_3; pfam13683
1225522007657	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1225522007658	DNA-binding interface [nucleotide binding]; DNA binding site
1225522007659	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1225522007660	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1225522007661	homodimer interface [polypeptide binding]; other site
1225522007662	active site
1225522007663	TDP-binding site; other site
1225522007664	acceptor substrate-binding pocket; other site
1225522007665	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522007666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007667	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1225522007668	Walker A/P-loop; other site
1225522007669	ATP binding site [chemical binding]; other site
1225522007670	Q-loop/lid; other site
1225522007671	ABC transporter signature motif; other site
1225522007672	Walker B; other site
1225522007673	D-loop; other site
1225522007674	H-loop/switch region; other site
1225522007675	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1225522007676	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1225522007677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522007678	Walker A/P-loop; other site
1225522007679	ATP binding site [chemical binding]; other site
1225522007680	Q-loop/lid; other site
1225522007681	ABC transporter signature motif; other site
1225522007682	Walker B; other site
1225522007683	D-loop; other site
1225522007684	H-loop/switch region; other site
1225522007685	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1225522007686	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1225522007687	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1225522007688	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1225522007689	outer membrane receptor FepA; Provisional; Region: PRK13528
1225522007690	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522007691	N-terminal plug; other site
1225522007692	ligand-binding site [chemical binding]; other site
1225522007693	secreted effector protein PipB2; Provisional; Region: PRK15196
1225522007694	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522007695	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522007696	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522007697	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522007698	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1225522007699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
1225522007700	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
1225522007701	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1225522007702	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1225522007703	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1225522007704	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1225522007705	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1225522007706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522007707	dimer interface [polypeptide binding]; other site
1225522007708	phosphorylation site [posttranslational modification]
1225522007709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522007710	ATP binding site [chemical binding]; other site
1225522007711	Mg2+ binding site [ion binding]; other site
1225522007712	G-X-G motif; other site
1225522007713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1225522007714	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1225522007715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1225522007716	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
1225522007717	substrate binding pocket [chemical binding]; other site
1225522007718	active site
1225522007719	iron coordination sites [ion binding]; other site
1225522007720	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
1225522007721	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1225522007722	tetramerization interface [polypeptide binding]; other site
1225522007723	NAD(P) binding site [chemical binding]; other site
1225522007724	catalytic residues [active]
1225522007725	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
1225522007726	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
1225522007727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522007728	DNA-binding site [nucleotide binding]; DNA binding site
1225522007729	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1225522007730	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1225522007731	bacterial OsmY and nodulation domain; Region: BON; smart00749
1225522007732	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522007733	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
1225522007734	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522007735	dimerization interface [polypeptide binding]; other site
1225522007736	putative DNA binding site [nucleotide binding]; other site
1225522007737	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1225522007738	putative Zn2+ binding site [ion binding]; other site
1225522007739	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1225522007740	active site residue [active]
1225522007741	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1225522007742	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
1225522007743	hypothetical protein; Provisional; Region: PRK10556
1225522007744	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1225522007745	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1225522007746	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1225522007747	catalytic residues [active]
1225522007748	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1225522007749	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1225522007750	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1225522007751	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1225522007752	active site
1225522007753	dimer interface [polypeptide binding]; other site
1225522007754	catalytic residues [active]
1225522007755	effector binding site; other site
1225522007756	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1225522007757	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1225522007758	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1225522007759	dimer interface [polypeptide binding]; other site
1225522007760	putative radical transfer pathway; other site
1225522007761	diiron center [ion binding]; other site
1225522007762	tyrosyl radical; other site
1225522007763	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
1225522007764	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1225522007765	Walker A/P-loop; other site
1225522007766	ATP binding site [chemical binding]; other site
1225522007767	Q-loop/lid; other site
1225522007768	ABC transporter signature motif; other site
1225522007769	Walker B; other site
1225522007770	D-loop; other site
1225522007771	H-loop/switch region; other site
1225522007772	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1225522007773	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
1225522007774	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1225522007775	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1225522007776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007777	transcriptional repressor MprA; Provisional; Region: PRK10870
1225522007778	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1225522007779	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1225522007780	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522007781	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522007782	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1225522007783	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1225522007784	glutamate--cysteine ligase; Provisional; Region: PRK02107
1225522007785	Predicted membrane protein [Function unknown]; Region: COG1238
1225522007786	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
1225522007787	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522007788	motif II; other site
1225522007789	carbon storage regulator; Provisional; Region: PRK01712
1225522007790	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1225522007791	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1225522007792	motif 1; other site
1225522007793	active site
1225522007794	motif 2; other site
1225522007795	motif 3; other site
1225522007796	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1225522007797	DHHA1 domain; Region: DHHA1; pfam02272
1225522007798	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1225522007799	recombinase A; Provisional; Region: recA; PRK09354
1225522007800	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1225522007801	hexamer interface [polypeptide binding]; other site
1225522007802	Walker A motif; other site
1225522007803	ATP binding site [chemical binding]; other site
1225522007804	Walker B motif; other site
1225522007805	hypothetical protein; Validated; Region: PRK03661
1225522007806	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
1225522007807	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
1225522007808	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1225522007809	Nucleoside recognition; Region: Gate; pfam07670
1225522007810	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1225522007811	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
1225522007812	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
1225522007813	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
1225522007814	putative NAD(P) binding site [chemical binding]; other site
1225522007815	active site
1225522007816	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
1225522007817	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1225522007818	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1225522007819	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522007820	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
1225522007821	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1225522007822	putative active site [active]
1225522007823	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1225522007824	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1225522007825	GAF domain; Region: GAF; pfam01590
1225522007826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007827	Walker A motif; other site
1225522007828	ATP binding site [chemical binding]; other site
1225522007829	Walker B motif; other site
1225522007830	arginine finger; other site
1225522007831	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
1225522007832	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1225522007833	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1225522007834	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1225522007835	iron binding site [ion binding]; other site
1225522007836	Acylphosphatase; Region: Acylphosphatase; pfam00708
1225522007837	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1225522007838	HypF finger; Region: zf-HYPF; pfam07503
1225522007839	HypF finger; Region: zf-HYPF; pfam07503
1225522007840	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1225522007841	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1225522007842	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1225522007843	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
1225522007844	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1225522007845	nickel binding site [ion binding]; other site
1225522007846	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
1225522007847	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1225522007848	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
1225522007849	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1225522007850	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
1225522007851	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1225522007852	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1225522007853	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1225522007854	NADH dehydrogenase; Region: NADHdh; cl00469
1225522007855	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
1225522007856	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1225522007857	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
1225522007858	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
1225522007859	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
1225522007860	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
1225522007861	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
1225522007862	hydrogenase assembly chaperone; Provisional; Region: PRK10409
1225522007863	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1225522007864	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1225522007865	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1225522007866	dimerization interface [polypeptide binding]; other site
1225522007867	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1225522007868	ATP binding site [chemical binding]; other site
1225522007869	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
1225522007870	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1225522007871	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1225522007872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522007873	Walker A motif; other site
1225522007874	ATP binding site [chemical binding]; other site
1225522007875	Walker B motif; other site
1225522007876	arginine finger; other site
1225522007877	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1225522007878	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
1225522007879	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1225522007880	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1225522007881	metal binding site [ion binding]; metal-binding site
1225522007882	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
1225522007883	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1225522007884	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1225522007885	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522007886	ABC-ATPase subunit  interface; other site
1225522007887	dimer interface [polypeptide binding]; other site
1225522007888	putative PBP binding regions; other site
1225522007889	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1225522007890	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1225522007891	ABC-ATPase subunit  interface; other site
1225522007892	dimer interface [polypeptide binding]; other site
1225522007893	putative PBP binding regions; other site
1225522007894	effector protein YopJ; Provisional; Region: PRK15371
1225522007895	transcriptional activator SprB; Provisional; Region: PRK15320
1225522007896	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
1225522007897	transcriptional regulator SirC; Provisional; Region: PRK15044
1225522007898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522007899	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
1225522007900	invasion protein OrgB; Provisional; Region: PRK15322
1225522007901	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
1225522007902	invasion protein OrgA; Provisional; Region: PRK15323
1225522007903	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
1225522007904	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
1225522007905	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
1225522007906	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
1225522007907	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
1225522007908	transcriptional regulator HilD; Provisional; Region: PRK15185
1225522007909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522007910	invasion protein regulator; Provisional; Region: PRK12370
1225522007911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522007912	DNA binding site [nucleotide binding]
1225522007913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1225522007914	binding surface
1225522007915	TPR motif; other site
1225522007916	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1225522007917	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1225522007918	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1225522007919	catalytic residue [active]
1225522007920	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
1225522007921	SicP binding; Region: SicP-binding; pfam09119
1225522007922	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
1225522007923	switch II binding region; other site
1225522007924	Rac1 P-loop interaction site [polypeptide binding]; other site
1225522007925	GTP binding residues [chemical binding]; other site
1225522007926	switch I binding region; other site
1225522007927	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
1225522007928	active site
1225522007929	chaperone protein SicP; Provisional; Region: PRK15329
1225522007930	putative acyl carrier protein IacP; Validated; Region: PRK08172
1225522007931	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
1225522007932	cell invasion protein SipD; Provisional; Region: PRK15330
1225522007933	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
1225522007934	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
1225522007935	chaperone protein SicA; Provisional; Region: PRK15331
1225522007936	Tetratricopeptide repeat; Region: TPR_3; pfam07720
1225522007937	Tetratricopeptide repeat; Region: TPR_3; pfam07720
1225522007938	type III secretion system protein SpaS; Validated; Region: PRK08156
1225522007939	type III secretion system protein SpaR; Provisional; Region: PRK15332
1225522007940	type III secretion system protein SpaQ; Provisional; Region: PRK15333
1225522007941	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
1225522007942	type III secretion system protein SpaO; Validated; Region: PRK08158
1225522007943	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1225522007944	antigen presentation protein SpaN; Provisional; Region: PRK15334
1225522007945	Surface presentation of antigens protein; Region: SPAN; pfam02510
1225522007946	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
1225522007947	ATP synthase SpaL; Validated; Region: PRK08149
1225522007948	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1225522007949	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1225522007950	Walker A motif; other site
1225522007951	ATP binding site [chemical binding]; other site
1225522007952	Walker B motif; other site
1225522007953	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
1225522007954	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
1225522007955	type III secretion system protein InvA; Provisional; Region: PRK15337
1225522007956	type III secretion system regulator InvE; Provisional; Region: PRK15338
1225522007957	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
1225522007958	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
1225522007959	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1225522007960	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1225522007961	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1225522007962	transcriptional regulator InvF; Provisional; Region: PRK15340
1225522007963	InvH outer membrane lipoprotein; Region: InvH; pfam04741
1225522007964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1225522007965	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
1225522007966	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1225522007967	active site
1225522007968	metal binding site [ion binding]; metal-binding site
1225522007969	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1225522007970	MutS domain I; Region: MutS_I; pfam01624
1225522007971	MutS domain II; Region: MutS_II; pfam05188
1225522007972	MutS domain III; Region: MutS_III; pfam05192
1225522007973	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1225522007974	Walker A/P-loop; other site
1225522007975	ATP binding site [chemical binding]; other site
1225522007976	Q-loop/lid; other site
1225522007977	ABC transporter signature motif; other site
1225522007978	Walker B; other site
1225522007979	D-loop; other site
1225522007980	H-loop/switch region; other site
1225522007981	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
1225522007982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522007983	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1225522007984	putative substrate translocation pore; other site
1225522007985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522007986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522007987	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1225522007988	putative effector binding pocket; other site
1225522007989	dimerization interface [polypeptide binding]; other site
1225522007990	GntP family permease; Region: GntP_permease; pfam02447
1225522007991	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1225522007992	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1225522007993	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1225522007994	putative NAD(P) binding site [chemical binding]; other site
1225522007995	active site
1225522007996	putative substrate binding site [chemical binding]; other site
1225522007997	hypothetical protein; Provisional; Region: PRK09989
1225522007998	putative aldolase; Validated; Region: PRK08130
1225522007999	intersubunit interface [polypeptide binding]; other site
1225522008000	active site
1225522008001	Zn2+ binding site [ion binding]; other site
1225522008002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1225522008003	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1225522008004	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1225522008005	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522008006	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522008007	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522008008	MarR family; Region: MarR_2; cl17246
1225522008009	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1225522008010	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1225522008011	Flavoprotein; Region: Flavoprotein; pfam02441
1225522008012	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1225522008013	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
1225522008014	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522008015	Peptidase family M23; Region: Peptidase_M23; pfam01551
1225522008016	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1225522008017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522008018	S-adenosylmethionine binding site [chemical binding]; other site
1225522008019	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1225522008020	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
1225522008021	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1225522008022	Permutation of conserved domain; other site
1225522008023	active site
1225522008024	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1225522008025	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1225522008026	homotrimer interaction site [polypeptide binding]; other site
1225522008027	zinc binding site [ion binding]; other site
1225522008028	CDP-binding sites; other site
1225522008029	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1225522008030	substrate binding site; other site
1225522008031	dimer interface; other site
1225522008032	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1225522008033	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1225522008034	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1225522008035	ligand-binding site [chemical binding]; other site
1225522008036	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1225522008037	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1225522008038	CysD dimerization site [polypeptide binding]; other site
1225522008039	G1 box; other site
1225522008040	putative GEF interaction site [polypeptide binding]; other site
1225522008041	GTP/Mg2+ binding site [chemical binding]; other site
1225522008042	Switch I region; other site
1225522008043	G2 box; other site
1225522008044	G3 box; other site
1225522008045	Switch II region; other site
1225522008046	G4 box; other site
1225522008047	G5 box; other site
1225522008048	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1225522008049	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1225522008050	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1225522008051	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1225522008052	Active Sites [active]
1225522008053	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
1225522008054	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1225522008055	metal binding site [ion binding]; metal-binding site
1225522008056	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
1225522008057	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
1225522008058	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1225522008059	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
1225522008060	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
1225522008061	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
1225522008062	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
1225522008063	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
1225522008064	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
1225522008065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1225522008066	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
1225522008067	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1225522008068	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1225522008069	Active Sites [active]
1225522008070	sulfite reductase subunit beta; Provisional; Region: PRK13504
1225522008071	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1225522008072	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1225522008073	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
1225522008074	Flavodoxin; Region: Flavodoxin_1; pfam00258
1225522008075	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1225522008076	FAD binding pocket [chemical binding]; other site
1225522008077	FAD binding motif [chemical binding]; other site
1225522008078	catalytic residues [active]
1225522008079	NAD binding pocket [chemical binding]; other site
1225522008080	phosphate binding motif [ion binding]; other site
1225522008081	beta-alpha-beta structure motif; other site
1225522008082	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1225522008083	active site
1225522008084	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
1225522008085	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1225522008086	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1225522008087	enolase; Provisional; Region: eno; PRK00077
1225522008088	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1225522008089	dimer interface [polypeptide binding]; other site
1225522008090	metal binding site [ion binding]; metal-binding site
1225522008091	substrate binding pocket [chemical binding]; other site
1225522008092	CTP synthetase; Validated; Region: pyrG; PRK05380
1225522008093	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1225522008094	Catalytic site [active]
1225522008095	active site
1225522008096	UTP binding site [chemical binding]; other site
1225522008097	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1225522008098	active site
1225522008099	putative oxyanion hole; other site
1225522008100	catalytic triad [active]
1225522008101	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1225522008102	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1225522008103	homodimer interface [polypeptide binding]; other site
1225522008104	metal binding site [ion binding]; metal-binding site
1225522008105	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1225522008106	homodimer interface [polypeptide binding]; other site
1225522008107	active site
1225522008108	putative chemical substrate binding site [chemical binding]; other site
1225522008109	metal binding site [ion binding]; metal-binding site
1225522008110	fimbrial protein SteA; Provisional; Region: PRK15261
1225522008111	putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274
1225522008112	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522008113	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522008114	putative fimbrial protein SteD; Provisional; Region: PRK15275
1225522008115	putative fimbrial subunit SteE; Provisional; Region: PRK15276
1225522008116	fimbrial protein SteF; Provisional; Region: PRK15260
1225522008117	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
1225522008118	HD domain; Region: HD_4; pfam13328
1225522008119	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1225522008120	synthetase active site [active]
1225522008121	NTP binding site [chemical binding]; other site
1225522008122	metal binding site [ion binding]; metal-binding site
1225522008123	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1225522008124	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1225522008125	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
1225522008126	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
1225522008127	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522008128	dimerization interface [polypeptide binding]; other site
1225522008129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522008130	dimer interface [polypeptide binding]; other site
1225522008131	phosphorylation site [posttranslational modification]
1225522008132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522008133	ATP binding site [chemical binding]; other site
1225522008134	Mg2+ binding site [ion binding]; other site
1225522008135	G-X-G motif; other site
1225522008136	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
1225522008137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522008138	active site
1225522008139	phosphorylation site [posttranslational modification]
1225522008140	intermolecular recognition site; other site
1225522008141	dimerization interface [polypeptide binding]; other site
1225522008142	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1225522008143	putative binding surface; other site
1225522008144	active site
1225522008145	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1225522008146	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1225522008147	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1225522008148	active site
1225522008149	tetramer interface [polypeptide binding]; other site
1225522008150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008151	D-galactonate transporter; Region: 2A0114; TIGR00893
1225522008152	putative substrate translocation pore; other site
1225522008153	flavodoxin; Provisional; Region: PRK08105
1225522008154	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1225522008155	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1225522008156	probable active site [active]
1225522008157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
1225522008158	SecY interacting protein Syd; Provisional; Region: PRK04968
1225522008159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1225522008160	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1225522008161	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1225522008162	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1225522008163	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1225522008164	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1225522008165	serine transporter; Region: stp; TIGR00814
1225522008166	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1225522008167	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1225522008168	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1225522008169	flap endonuclease-like protein; Provisional; Region: PRK09482
1225522008170	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1225522008171	active site
1225522008172	metal binding site 1 [ion binding]; metal-binding site
1225522008173	putative 5' ssDNA interaction site; other site
1225522008174	metal binding site 3; metal-binding site
1225522008175	metal binding site 2 [ion binding]; metal-binding site
1225522008176	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1225522008177	putative DNA binding site [nucleotide binding]; other site
1225522008178	putative metal binding site [ion binding]; other site
1225522008179	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
1225522008180	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1225522008181	dimer interface [polypeptide binding]; other site
1225522008182	active site
1225522008183	metal binding site [ion binding]; metal-binding site
1225522008184	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1225522008185	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1225522008186	intersubunit interface [polypeptide binding]; other site
1225522008187	active site
1225522008188	Zn2+ binding site [ion binding]; other site
1225522008189	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1225522008190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008191	putative substrate translocation pore; other site
1225522008192	L-fucose isomerase; Provisional; Region: fucI; PRK10991
1225522008193	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
1225522008194	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1225522008195	trimer interface [polypeptide binding]; other site
1225522008196	substrate binding site [chemical binding]; other site
1225522008197	Mn binding site [ion binding]; other site
1225522008198	L-fuculokinase; Provisional; Region: PRK10331
1225522008199	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1225522008200	nucleotide binding site [chemical binding]; other site
1225522008201	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
1225522008202	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
1225522008203	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1225522008204	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522008205	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1225522008206	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1225522008207	hypothetical protein; Provisional; Region: PRK10873
1225522008208	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1225522008209	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008210	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1225522008211	dimerization interface [polypeptide binding]; other site
1225522008212	substrate binding pocket [chemical binding]; other site
1225522008213	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1225522008214	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1225522008215	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1225522008216	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522008217	catalytic residue [active]
1225522008218	CsdA-binding activator; Provisional; Region: PRK15019
1225522008219	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1225522008220	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
1225522008221	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1225522008222	putative ATP binding site [chemical binding]; other site
1225522008223	putative substrate interface [chemical binding]; other site
1225522008224	murein transglycosylase A; Provisional; Region: mltA; PRK11162
1225522008225	murein hydrolase B; Provisional; Region: PRK10760; cl17906
1225522008226	MltA specific insert domain; Region: MltA; pfam03562
1225522008227	3D domain; Region: 3D; pfam06725
1225522008228	AMIN domain; Region: AMIN; pfam11741
1225522008229	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1225522008230	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1225522008231	active site
1225522008232	metal binding site [ion binding]; metal-binding site
1225522008233	N-acetylglutamate synthase; Validated; Region: PRK05279
1225522008234	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1225522008235	putative feedback inhibition sensing region; other site
1225522008236	putative nucleotide binding site [chemical binding]; other site
1225522008237	putative substrate binding site [chemical binding]; other site
1225522008238	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522008239	Coenzyme A binding pocket [chemical binding]; other site
1225522008240	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1225522008241	AAA domain; Region: AAA_30; pfam13604
1225522008242	Family description; Region: UvrD_C_2; pfam13538
1225522008243	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1225522008244	protease3; Provisional; Region: PRK15101
1225522008245	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1225522008246	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1225522008247	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1225522008248	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
1225522008249	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1225522008250	hypothetical protein; Provisional; Region: PRK10332
1225522008251	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
1225522008252	hypothetical protein; Provisional; Region: PRK11521
1225522008253	hypothetical protein; Provisional; Region: PRK10557
1225522008254	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1225522008255	hypothetical protein; Provisional; Region: PRK10506
1225522008256	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1225522008257	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1225522008258	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1225522008259	dimerization interface [polypeptide binding]; other site
1225522008260	active site
1225522008261	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1225522008262	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
1225522008263	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1225522008264	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1225522008265	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1225522008266	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1225522008267	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1225522008268	putative active site [active]
1225522008269	Ap4A binding site [chemical binding]; other site
1225522008270	nudix motif; other site
1225522008271	putative metal binding site [ion binding]; other site
1225522008272	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
1225522008273	putative DNA-binding cleft [nucleotide binding]; other site
1225522008274	putative DNA clevage site; other site
1225522008275	molecular lever; other site
1225522008276	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1225522008277	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1225522008278	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522008279	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522008280	active site
1225522008281	catalytic tetrad [active]
1225522008282	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1225522008283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008284	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
1225522008285	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1225522008286	putative acyl-acceptor binding pocket; other site
1225522008287	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
1225522008288	acyl-activating enzyme (AAE) consensus motif; other site
1225522008289	putative AMP binding site [chemical binding]; other site
1225522008290	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
1225522008291	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522008292	DNA binding site [nucleotide binding]
1225522008293	domain linker motif; other site
1225522008294	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1225522008295	dimerization interface (closed form) [polypeptide binding]; other site
1225522008296	ligand binding site [chemical binding]; other site
1225522008297	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1225522008298	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522008299	DNA binding site [nucleotide binding]
1225522008300	domain linker motif; other site
1225522008301	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1225522008302	dimerization interface (closed form) [polypeptide binding]; other site
1225522008303	ligand binding site [chemical binding]; other site
1225522008304	diaminopimelate decarboxylase; Provisional; Region: PRK11165
1225522008305	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1225522008306	active site
1225522008307	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522008308	substrate binding site [chemical binding]; other site
1225522008309	catalytic residues [active]
1225522008310	dimer interface [polypeptide binding]; other site
1225522008311	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1225522008312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008313	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522008314	dimerization interface [polypeptide binding]; other site
1225522008315	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1225522008316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008317	putative substrate translocation pore; other site
1225522008318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008319	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
1225522008320	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1225522008321	NADP binding site [chemical binding]; other site
1225522008322	homodimer interface [polypeptide binding]; other site
1225522008323	active site
1225522008324	putative acyltransferase; Provisional; Region: PRK05790
1225522008325	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1225522008326	dimer interface [polypeptide binding]; other site
1225522008327	active site
1225522008328	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522008329	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008330	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1225522008331	dimerization interface [polypeptide binding]; other site
1225522008332	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
1225522008333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1225522008334	Peptidase family M23; Region: Peptidase_M23; pfam01551
1225522008335	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1225522008336	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1225522008337	active site
1225522008338	metal binding site [ion binding]; metal-binding site
1225522008339	nudix motif; other site
1225522008340	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
1225522008341	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1225522008342	dimer interface [polypeptide binding]; other site
1225522008343	putative anticodon binding site; other site
1225522008344	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1225522008345	motif 1; other site
1225522008346	active site
1225522008347	motif 2; other site
1225522008348	motif 3; other site
1225522008349	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1225522008350	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1225522008351	RF-1 domain; Region: RF-1; pfam00472
1225522008352	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1225522008353	DHH family; Region: DHH; pfam01368
1225522008354	DHHA1 domain; Region: DHHA1; pfam02272
1225522008355	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1225522008356	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1225522008357	dimerization domain [polypeptide binding]; other site
1225522008358	dimer interface [polypeptide binding]; other site
1225522008359	catalytic residues [active]
1225522008360	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1225522008361	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1225522008362	active site
1225522008363	Int/Topo IB signature motif; other site
1225522008364	flavodoxin FldB; Provisional; Region: PRK12359
1225522008365	hypothetical protein; Provisional; Region: PRK10878
1225522008366	putative global regulator; Reviewed; Region: PRK09559
1225522008367	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1225522008368	hemolysin; Provisional; Region: PRK15087
1225522008369	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1225522008370	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1225522008371	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
1225522008372	beta-galactosidase; Region: BGL; TIGR03356
1225522008373	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
1225522008374	glycine dehydrogenase; Provisional; Region: PRK05367
1225522008375	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1225522008376	tetramer interface [polypeptide binding]; other site
1225522008377	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522008378	catalytic residue [active]
1225522008379	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1225522008380	tetramer interface [polypeptide binding]; other site
1225522008381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522008382	catalytic residue [active]
1225522008383	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1225522008384	lipoyl attachment site [posttranslational modification]; other site
1225522008385	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1225522008386	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1225522008387	oxidoreductase; Provisional; Region: PRK08013
1225522008388	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1225522008389	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1225522008390	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1225522008391	proline aminopeptidase P II; Provisional; Region: PRK10879
1225522008392	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1225522008393	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1225522008394	active site
1225522008395	hypothetical protein; Reviewed; Region: PRK01736
1225522008396	Z-ring-associated protein; Provisional; Region: PRK10972
1225522008397	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
1225522008398	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1225522008399	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1225522008400	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1225522008401	ligand binding site [chemical binding]; other site
1225522008402	NAD binding site [chemical binding]; other site
1225522008403	tetramer interface [polypeptide binding]; other site
1225522008404	catalytic site [active]
1225522008405	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1225522008406	L-serine binding site [chemical binding]; other site
1225522008407	ACT domain interface; other site
1225522008408	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1225522008409	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1225522008410	active site
1225522008411	dimer interface [polypeptide binding]; other site
1225522008412	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1225522008413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008414	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
1225522008415	putative dimerization interface [polypeptide binding]; other site
1225522008416	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1225522008417	oxidative stress defense protein; Provisional; Region: PRK11087
1225522008418	arginine exporter protein; Provisional; Region: PRK09304
1225522008419	mechanosensitive channel MscS; Provisional; Region: PRK10334
1225522008420	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522008421	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1225522008422	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1225522008423	active site
1225522008424	intersubunit interface [polypeptide binding]; other site
1225522008425	zinc binding site [ion binding]; other site
1225522008426	Na+ binding site [ion binding]; other site
1225522008427	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1225522008428	Phosphoglycerate kinase; Region: PGK; pfam00162
1225522008429	substrate binding site [chemical binding]; other site
1225522008430	hinge regions; other site
1225522008431	ADP binding site [chemical binding]; other site
1225522008432	catalytic site [active]
1225522008433	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
1225522008434	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1225522008435	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1225522008436	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1225522008437	trimer interface [polypeptide binding]; other site
1225522008438	putative Zn binding site [ion binding]; other site
1225522008439	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1225522008440	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1225522008441	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1225522008442	Walker A/P-loop; other site
1225522008443	ATP binding site [chemical binding]; other site
1225522008444	Q-loop/lid; other site
1225522008445	ABC transporter signature motif; other site
1225522008446	Walker B; other site
1225522008447	D-loop; other site
1225522008448	H-loop/switch region; other site
1225522008449	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1225522008450	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1225522008451	Walker A/P-loop; other site
1225522008452	ATP binding site [chemical binding]; other site
1225522008453	Q-loop/lid; other site
1225522008454	ABC transporter signature motif; other site
1225522008455	Walker B; other site
1225522008456	D-loop; other site
1225522008457	H-loop/switch region; other site
1225522008458	transketolase; Reviewed; Region: PRK12753
1225522008459	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1225522008460	TPP-binding site [chemical binding]; other site
1225522008461	dimer interface [polypeptide binding]; other site
1225522008462	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1225522008463	PYR/PP interface [polypeptide binding]; other site
1225522008464	dimer interface [polypeptide binding]; other site
1225522008465	TPP binding site [chemical binding]; other site
1225522008466	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1225522008467	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1225522008468	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1225522008469	agmatinase; Region: agmatinase; TIGR01230
1225522008470	oligomer interface [polypeptide binding]; other site
1225522008471	putative active site [active]
1225522008472	Mn binding site [ion binding]; other site
1225522008473	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1225522008474	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1225522008475	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1225522008476	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1225522008477	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1225522008478	putative NAD(P) binding site [chemical binding]; other site
1225522008479	catalytic Zn binding site [ion binding]; other site
1225522008480	structural Zn binding site [ion binding]; other site
1225522008481	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1225522008482	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1225522008483	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1225522008484	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1225522008485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522008486	DNA-binding site [nucleotide binding]; DNA binding site
1225522008487	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1225522008488	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
1225522008489	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
1225522008490	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1225522008491	dimer interface [polypeptide binding]; other site
1225522008492	active site
1225522008493	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522008494	catalytic residues [active]
1225522008495	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1225522008496	Virulence promoting factor; Region: YqgB; pfam11036
1225522008497	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1225522008498	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1225522008499	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1225522008500	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1225522008501	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1225522008502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008503	putative substrate translocation pore; other site
1225522008504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008505	hypothetical protein; Provisional; Region: PRK04860
1225522008506	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1225522008507	DNA-specific endonuclease I; Provisional; Region: PRK15137
1225522008508	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
1225522008509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1225522008510	RNA methyltransferase, RsmE family; Region: TIGR00046
1225522008511	glutathione synthetase; Provisional; Region: PRK05246
1225522008512	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1225522008513	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1225522008514	hypothetical protein; Validated; Region: PRK00228
1225522008515	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1225522008516	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1225522008517	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1225522008518	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1225522008519	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1225522008520	Walker A motif; other site
1225522008521	ATP binding site [chemical binding]; other site
1225522008522	Walker B motif; other site
1225522008523	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1225522008524	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522008525	catalytic residue [active]
1225522008526	YGGT family; Region: YGGT; pfam02325
1225522008527	YGGT family; Region: YGGT; pfam02325
1225522008528	hypothetical protein; Validated; Region: PRK05090
1225522008529	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1225522008530	active site
1225522008531	dimerization interface [polypeptide binding]; other site
1225522008532	HemN family oxidoreductase; Provisional; Region: PRK05660
1225522008533	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522008534	FeS/SAM binding site; other site
1225522008535	HemN C-terminal domain; Region: HemN_C; pfam06969
1225522008536	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
1225522008537	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
1225522008538	homodimer interface [polypeptide binding]; other site
1225522008539	active site
1225522008540	hypothetical protein; Provisional; Region: PRK10626
1225522008541	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
1225522008542	hypothetical protein; Provisional; Region: PRK11702
1225522008543	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1225522008544	adenine DNA glycosylase; Provisional; Region: PRK10880
1225522008545	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1225522008546	minor groove reading motif; other site
1225522008547	helix-hairpin-helix signature motif; other site
1225522008548	substrate binding pocket [chemical binding]; other site
1225522008549	active site
1225522008550	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1225522008551	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1225522008552	DNA binding and oxoG recognition site [nucleotide binding]
1225522008553	oxidative damage protection protein; Provisional; Region: PRK05408
1225522008554	murein transglycosylase C; Provisional; Region: mltC; PRK11671
1225522008555	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
1225522008556	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1225522008557	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1225522008558	catalytic residue [active]
1225522008559	nucleoside transporter; Region: 2A0110; TIGR00889
1225522008560	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
1225522008561	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
1225522008562	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1225522008563	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1225522008564	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1225522008565	putative active site [active]
1225522008566	putative catalytic site [active]
1225522008567	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1225522008568	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1225522008569	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008570	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1225522008571	putative dimerization interface [polypeptide binding]; other site
1225522008572	putative substrate binding pocket [chemical binding]; other site
1225522008573	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1225522008574	Sulfatase; Region: Sulfatase; pfam00884
1225522008575	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1225522008576	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522008577	FeS/SAM binding site; other site
1225522008578	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1225522008579	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1225522008580	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522008581	DNA binding residues [nucleotide binding]
1225522008582	dimerization interface [polypeptide binding]; other site
1225522008583	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
1225522008584	Amino acid permease; Region: AA_permease_2; pfam13520
1225522008585	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1225522008586	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1225522008587	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1225522008588	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
1225522008589	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1225522008590	NAD(P) binding site [chemical binding]; other site
1225522008591	catalytic residues [active]
1225522008592	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
1225522008593	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
1225522008594	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
1225522008595	active site
1225522008596	catalytic site [active]
1225522008597	Zn binding site [ion binding]; other site
1225522008598	tetramer interface [polypeptide binding]; other site
1225522008599	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1225522008600	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1225522008601	putative active site [active]
1225522008602	catalytic triad [active]
1225522008603	putative dimer interface [polypeptide binding]; other site
1225522008604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522008605	D-galactonate transporter; Region: 2A0114; TIGR00893
1225522008606	putative substrate translocation pore; other site
1225522008607	mannonate dehydratase; Provisional; Region: PRK03906
1225522008608	mannonate dehydratase; Region: uxuA; TIGR00695
1225522008609	D-mannonate oxidoreductase; Provisional; Region: PRK15037
1225522008610	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1225522008611	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1225522008612	Glucuronate isomerase; Region: UxaC; pfam02614
1225522008613	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1225522008614	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522008615	dimer interface [polypeptide binding]; other site
1225522008616	putative CheW interface [polypeptide binding]; other site
1225522008617	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1225522008618	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
1225522008619	CHAP domain; Region: CHAP; pfam05257
1225522008620	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1225522008621	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1225522008622	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
1225522008623	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
1225522008624	putative ligand binding residues [chemical binding]; other site
1225522008625	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1225522008626	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
1225522008627	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1225522008628	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
1225522008629	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
1225522008630	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1225522008631	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1225522008632	putative substrate-binding site; other site
1225522008633	nickel binding site [ion binding]; other site
1225522008634	hydrogenase 2 large subunit; Provisional; Region: PRK10467
1225522008635	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1225522008636	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
1225522008637	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
1225522008638	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
1225522008639	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1225522008640	hydrogenase 2 small subunit; Provisional; Region: PRK10468
1225522008641	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
1225522008642	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1225522008643	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
1225522008644	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
1225522008645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522008646	dimerization interface [polypeptide binding]; other site
1225522008647	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522008648	dimer interface [polypeptide binding]; other site
1225522008649	putative CheW interface [polypeptide binding]; other site
1225522008650	hypothetical protein; Provisional; Region: PRK05208
1225522008651	oxidoreductase; Provisional; Region: PRK07985
1225522008652	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1225522008653	NAD binding site [chemical binding]; other site
1225522008654	metal binding site [ion binding]; metal-binding site
1225522008655	active site
1225522008656	biopolymer transport protein ExbD; Provisional; Region: PRK11267
1225522008657	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1225522008658	biopolymer transport protein ExbB; Provisional; Region: PRK10414
1225522008659	cystathionine beta-lyase; Provisional; Region: PRK08114
1225522008660	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1225522008661	homodimer interface [polypeptide binding]; other site
1225522008662	substrate-cofactor binding pocket; other site
1225522008663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522008664	catalytic residue [active]
1225522008665	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1225522008666	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1225522008667	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1225522008668	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1225522008669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522008670	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522008671	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1225522008672	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1225522008673	dimer interface [polypeptide binding]; other site
1225522008674	active site
1225522008675	metal binding site [ion binding]; metal-binding site
1225522008676	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1225522008677	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1225522008678	active site
1225522008679	catalytic tetrad [active]
1225522008680	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1225522008681	nucleotide binding site/active site [active]
1225522008682	catalytic residue [active]
1225522008683	hypothetical protein; Provisional; Region: PRK01254
1225522008684	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1225522008685	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1225522008686	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1225522008687	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1225522008688	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1225522008689	DctM-like transporters; Region: DctM; pfam06808
1225522008690	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
1225522008691	FtsI repressor; Provisional; Region: PRK10883
1225522008692	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1225522008693	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1225522008694	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
1225522008695	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1225522008696	putative acyl-acceptor binding pocket; other site
1225522008697	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
1225522008698	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1225522008699	CAP-like domain; other site
1225522008700	active site
1225522008701	primary dimer interface [polypeptide binding]; other site
1225522008702	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1225522008703	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522008704	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522008705	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
1225522008706	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
1225522008707	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1225522008708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522008709	active site
1225522008710	phosphorylation site [posttranslational modification]
1225522008711	intermolecular recognition site; other site
1225522008712	dimerization interface [polypeptide binding]; other site
1225522008713	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522008714	DNA binding site [nucleotide binding]
1225522008715	sensor protein QseC; Provisional; Region: PRK10337
1225522008716	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
1225522008717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522008718	dimer interface [polypeptide binding]; other site
1225522008719	phosphorylation site [posttranslational modification]
1225522008720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522008721	ATP binding site [chemical binding]; other site
1225522008722	Mg2+ binding site [ion binding]; other site
1225522008723	G-X-G motif; other site
1225522008724	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1225522008725	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1225522008726	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
1225522008727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522008728	ATP binding site [chemical binding]; other site
1225522008729	Mg2+ binding site [ion binding]; other site
1225522008730	G-X-G motif; other site
1225522008731	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1225522008732	anchoring element; other site
1225522008733	dimer interface [polypeptide binding]; other site
1225522008734	ATP binding site [chemical binding]; other site
1225522008735	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1225522008736	active site
1225522008737	metal binding site [ion binding]; metal-binding site
1225522008738	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1225522008739	esterase YqiA; Provisional; Region: PRK11071
1225522008740	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1225522008741	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1225522008742	active site
1225522008743	metal binding site [ion binding]; metal-binding site
1225522008744	hexamer interface [polypeptide binding]; other site
1225522008745	putative dehydrogenase; Provisional; Region: PRK11039
1225522008746	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1225522008747	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1225522008748	dimer interface [polypeptide binding]; other site
1225522008749	ADP-ribose binding site [chemical binding]; other site
1225522008750	active site
1225522008751	nudix motif; other site
1225522008752	metal binding site [ion binding]; metal-binding site
1225522008753	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
1225522008754	hypothetical protein; Provisional; Region: PRK11653
1225522008755	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1225522008756	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1225522008757	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1225522008758	putative active site [active]
1225522008759	metal binding site [ion binding]; metal-binding site
1225522008760	zinc transporter ZupT; Provisional; Region: PRK04201
1225522008761	ZIP Zinc transporter; Region: Zip; pfam02535
1225522008762	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
1225522008763	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
1225522008764	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1225522008765	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1225522008766	catalytic residues [active]
1225522008767	hinge region; other site
1225522008768	alpha helical domain; other site
1225522008769	putative disulfide oxidoreductase; Provisional; Region: PRK04307
1225522008770	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1225522008771	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1225522008772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1225522008773	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
1225522008774	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
1225522008775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1225522008776	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1225522008777	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1225522008778	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1225522008779	putative ribose interaction site [chemical binding]; other site
1225522008780	putative ADP binding site [chemical binding]; other site
1225522008781	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1225522008782	active site
1225522008783	nucleotide binding site [chemical binding]; other site
1225522008784	HIGH motif; other site
1225522008785	KMSKS motif; other site
1225522008786	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1225522008787	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1225522008788	metal binding triad; other site
1225522008789	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1225522008790	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1225522008791	metal binding triad; other site
1225522008792	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1225522008793	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1225522008794	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1225522008795	putative active site [active]
1225522008796	putative metal binding residues [ion binding]; other site
1225522008797	signature motif; other site
1225522008798	putative triphosphate binding site [ion binding]; other site
1225522008799	CHAD domain; Region: CHAD; pfam05235
1225522008800	SH3 domain-containing protein; Provisional; Region: PRK10884
1225522008801	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1225522008802	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1225522008803	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1225522008804	active site
1225522008805	NTP binding site [chemical binding]; other site
1225522008806	metal binding triad [ion binding]; metal-binding site
1225522008807	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1225522008808	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1225522008809	Zn2+ binding site [ion binding]; other site
1225522008810	Mg2+ binding site [ion binding]; other site
1225522008811	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1225522008812	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1225522008813	homooctamer interface [polypeptide binding]; other site
1225522008814	active site
1225522008815	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1225522008816	UGMP family protein; Validated; Region: PRK09604
1225522008817	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1225522008818	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1225522008819	DNA primase; Validated; Region: dnaG; PRK05667
1225522008820	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1225522008821	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1225522008822	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1225522008823	active site
1225522008824	metal binding site [ion binding]; metal-binding site
1225522008825	interdomain interaction site; other site
1225522008826	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1225522008827	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1225522008828	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1225522008829	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1225522008830	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1225522008831	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1225522008832	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1225522008833	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1225522008834	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1225522008835	DNA binding residues [nucleotide binding]
1225522008836	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1225522008837	active site
1225522008838	SUMO-1 interface [polypeptide binding]; other site
1225522008839	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1225522008840	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1225522008841	FAD binding pocket [chemical binding]; other site
1225522008842	FAD binding motif [chemical binding]; other site
1225522008843	phosphate binding motif [ion binding]; other site
1225522008844	NAD binding pocket [chemical binding]; other site
1225522008845	Predicted transcriptional regulators [Transcription]; Region: COG1695
1225522008846	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1225522008847	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1225522008848	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522008849	dimerization interface [polypeptide binding]; other site
1225522008850	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1225522008851	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522008852	dimer interface [polypeptide binding]; other site
1225522008853	putative CheW interface [polypeptide binding]; other site
1225522008854	PAS fold; Region: PAS_3; pfam08447
1225522008855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522008856	putative active site [active]
1225522008857	heme pocket [chemical binding]; other site
1225522008858	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1225522008859	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1225522008860	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522008861	dimer interface [polypeptide binding]; other site
1225522008862	putative CheW interface [polypeptide binding]; other site
1225522008863	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
1225522008864	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1225522008865	inhibitor-cofactor binding pocket; inhibition site
1225522008866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522008867	catalytic residue [active]
1225522008868	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1225522008869	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1225522008870	active site
1225522008871	FMN binding site [chemical binding]; other site
1225522008872	2,4-decadienoyl-CoA binding site; other site
1225522008873	catalytic residue [active]
1225522008874	4Fe-4S cluster binding site [ion binding]; other site
1225522008875	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1225522008876	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522008877	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
1225522008878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522008879	S-adenosylmethionine binding site [chemical binding]; other site
1225522008880	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1225522008881	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1225522008882	putative active site [active]
1225522008883	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1225522008884	serine/threonine transporter SstT; Provisional; Region: PRK13628
1225522008885	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1225522008886	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1225522008887	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1225522008888	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
1225522008889	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
1225522008890	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
1225522008891	Predicted membrane protein [Function unknown]; Region: COG5393
1225522008892	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1225522008893	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1225522008894	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1225522008895	putative dimer interface [polypeptide binding]; other site
1225522008896	N-terminal domain interface [polypeptide binding]; other site
1225522008897	putative substrate binding pocket (H-site) [chemical binding]; other site
1225522008898	Predicted membrane protein [Function unknown]; Region: COG3152
1225522008899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008900	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1225522008901	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522008902	dimerization interface [polypeptide binding]; other site
1225522008903	Pirin-related protein [General function prediction only]; Region: COG1741
1225522008904	Pirin; Region: Pirin; pfam02678
1225522008905	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1225522008906	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1225522008907	Pyruvate formate lyase 1; Region: PFL1; cd01678
1225522008908	coenzyme A binding site [chemical binding]; other site
1225522008909	active site
1225522008910	catalytic residues [active]
1225522008911	glycine loop; other site
1225522008912	propionate/acetate kinase; Provisional; Region: PRK12379
1225522008913	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
1225522008914	threonine/serine transporter TdcC; Provisional; Region: PRK13629
1225522008915	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1225522008916	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1225522008917	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1225522008918	tetramer interface [polypeptide binding]; other site
1225522008919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522008920	catalytic residue [active]
1225522008921	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
1225522008922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522008923	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
1225522008924	putative substrate binding pocket [chemical binding]; other site
1225522008925	putative dimerization interface [polypeptide binding]; other site
1225522008926	glycerate kinase I; Provisional; Region: PRK10342
1225522008927	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
1225522008928	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1225522008929	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
1225522008930	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1225522008931	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1225522008932	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1225522008933	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1225522008934	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1225522008935	intersubunit interface [polypeptide binding]; other site
1225522008936	active site
1225522008937	zinc binding site [ion binding]; other site
1225522008938	Na+ binding site [ion binding]; other site
1225522008939	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
1225522008940	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522008941	active site
1225522008942	phosphorylation site [posttranslational modification]
1225522008943	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1225522008944	active site
1225522008945	P-loop; other site
1225522008946	phosphorylation site [posttranslational modification]
1225522008947	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1225522008948	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1225522008949	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
1225522008950	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1225522008951	putative NAD(P) binding site [chemical binding]; other site
1225522008952	catalytic Zn binding site [ion binding]; other site
1225522008953	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522008954	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522008955	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522008956	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
1225522008957	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1225522008958	putative SAM binding site [chemical binding]; other site
1225522008959	putative homodimer interface [polypeptide binding]; other site
1225522008960	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1225522008961	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
1225522008962	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1225522008963	putative ligand binding site [chemical binding]; other site
1225522008964	TIGR00252 family protein; Region: TIGR00252
1225522008965	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1225522008966	dimer interface [polypeptide binding]; other site
1225522008967	active site
1225522008968	outer membrane lipoprotein; Provisional; Region: PRK11023
1225522008969	BON domain; Region: BON; pfam04972
1225522008970	BON domain; Region: BON; pfam04972
1225522008971	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1225522008972	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1225522008973	NAD binding site [chemical binding]; other site
1225522008974	active site
1225522008975	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1225522008976	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1225522008977	proposed catalytic triad [active]
1225522008978	conserved cys residue [active]
1225522008979	hypothetical protein; Provisional; Region: PRK03467
1225522008980	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1225522008981	GIY-YIG motif/motif A; other site
1225522008982	putative active site [active]
1225522008983	putative metal binding site [ion binding]; other site
1225522008984	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1225522008985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522008986	Coenzyme A binding pocket [chemical binding]; other site
1225522008987	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1225522008988	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1225522008989	Peptidase family U32; Region: Peptidase_U32; pfam01136
1225522008990	putative protease; Provisional; Region: PRK15447
1225522008991	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1225522008992	hypothetical protein; Provisional; Region: PRK10508
1225522008993	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1225522008994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1225522008995	tryptophan permease; Provisional; Region: PRK10483
1225522008996	aromatic amino acid transport protein; Region: araaP; TIGR00837
1225522008997	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1225522008998	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1225522008999	ATP binding site [chemical binding]; other site
1225522009000	Mg++ binding site [ion binding]; other site
1225522009001	motif III; other site
1225522009002	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522009003	nucleotide binding region [chemical binding]; other site
1225522009004	ATP-binding site [chemical binding]; other site
1225522009005	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1225522009006	putative RNA binding site [nucleotide binding]; other site
1225522009007	lipoprotein NlpI; Provisional; Region: PRK11189
1225522009008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1225522009009	binding surface
1225522009010	TPR motif; other site
1225522009011	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1225522009012	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1225522009013	RNase E interface [polypeptide binding]; other site
1225522009014	trimer interface [polypeptide binding]; other site
1225522009015	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1225522009016	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1225522009017	RNase E interface [polypeptide binding]; other site
1225522009018	trimer interface [polypeptide binding]; other site
1225522009019	active site
1225522009020	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1225522009021	putative nucleic acid binding region [nucleotide binding]; other site
1225522009022	G-X-X-G motif; other site
1225522009023	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1225522009024	RNA binding site [nucleotide binding]; other site
1225522009025	domain interface; other site
1225522009026	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1225522009027	16S/18S rRNA binding site [nucleotide binding]; other site
1225522009028	S13e-L30e interaction site [polypeptide binding]; other site
1225522009029	25S rRNA binding site [nucleotide binding]; other site
1225522009030	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1225522009031	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1225522009032	RNA binding site [nucleotide binding]; other site
1225522009033	active site
1225522009034	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1225522009035	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1225522009036	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1225522009037	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1225522009038	translation initiation factor IF-2; Region: IF-2; TIGR00487
1225522009039	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1225522009040	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1225522009041	G1 box; other site
1225522009042	putative GEF interaction site [polypeptide binding]; other site
1225522009043	GTP/Mg2+ binding site [chemical binding]; other site
1225522009044	Switch I region; other site
1225522009045	G2 box; other site
1225522009046	G3 box; other site
1225522009047	Switch II region; other site
1225522009048	G4 box; other site
1225522009049	G5 box; other site
1225522009050	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1225522009051	Translation-initiation factor 2; Region: IF-2; pfam11987
1225522009052	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1225522009053	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1225522009054	NusA N-terminal domain; Region: NusA_N; pfam08529
1225522009055	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1225522009056	RNA binding site [nucleotide binding]; other site
1225522009057	homodimer interface [polypeptide binding]; other site
1225522009058	NusA-like KH domain; Region: KH_5; pfam13184
1225522009059	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1225522009060	G-X-X-G motif; other site
1225522009061	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1225522009062	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1225522009063	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1225522009064	hypothetical protein; Provisional; Region: PRK14641
1225522009065	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1225522009066	putative oligomer interface [polypeptide binding]; other site
1225522009067	putative RNA binding site [nucleotide binding]; other site
1225522009068	argininosuccinate synthase; Validated; Region: PRK05370
1225522009069	argininosuccinate synthase; Provisional; Region: PRK13820
1225522009070	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1225522009071	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1225522009072	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1225522009073	active site
1225522009074	substrate binding site [chemical binding]; other site
1225522009075	metal binding site [ion binding]; metal-binding site
1225522009076	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1225522009077	dihydropteroate synthase; Region: DHPS; TIGR01496
1225522009078	substrate binding pocket [chemical binding]; other site
1225522009079	dimer interface [polypeptide binding]; other site
1225522009080	inhibitor binding site; inhibition site
1225522009081	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1225522009082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522009083	Walker A motif; other site
1225522009084	ATP binding site [chemical binding]; other site
1225522009085	Walker B motif; other site
1225522009086	arginine finger; other site
1225522009087	Peptidase family M41; Region: Peptidase_M41; pfam01434
1225522009088	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1225522009089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522009090	S-adenosylmethionine binding site [chemical binding]; other site
1225522009091	RNA-binding protein YhbY; Provisional; Region: PRK10343
1225522009092	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1225522009093	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1225522009094	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1225522009095	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
1225522009096	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1225522009097	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1225522009098	GTP1/OBG; Region: GTP1_OBG; pfam01018
1225522009099	Obg GTPase; Region: Obg; cd01898
1225522009100	G1 box; other site
1225522009101	GTP/Mg2+ binding site [chemical binding]; other site
1225522009102	Switch I region; other site
1225522009103	G2 box; other site
1225522009104	G3 box; other site
1225522009105	Switch II region; other site
1225522009106	G4 box; other site
1225522009107	G5 box; other site
1225522009108	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1225522009109	EamA-like transporter family; Region: EamA; pfam00892
1225522009110	EamA-like transporter family; Region: EamA; pfam00892
1225522009111	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1225522009112	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1225522009113	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1225522009114	substrate binding pocket [chemical binding]; other site
1225522009115	chain length determination region; other site
1225522009116	substrate-Mg2+ binding site; other site
1225522009117	catalytic residues [active]
1225522009118	aspartate-rich region 1; other site
1225522009119	active site lid residues [active]
1225522009120	aspartate-rich region 2; other site
1225522009121	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
1225522009122	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1225522009123	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1225522009124	hinge; other site
1225522009125	active site
1225522009126	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1225522009127	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1225522009128	anti sigma factor interaction site; other site
1225522009129	regulatory phosphorylation site [posttranslational modification]; other site
1225522009130	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
1225522009131	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1225522009132	mce related protein; Region: MCE; pfam02470
1225522009133	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1225522009134	conserved hypothetical integral membrane protein; Region: TIGR00056
1225522009135	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1225522009136	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1225522009137	Walker A/P-loop; other site
1225522009138	ATP binding site [chemical binding]; other site
1225522009139	Q-loop/lid; other site
1225522009140	ABC transporter signature motif; other site
1225522009141	Walker B; other site
1225522009142	D-loop; other site
1225522009143	H-loop/switch region; other site
1225522009144	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
1225522009145	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1225522009146	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1225522009147	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1225522009148	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1225522009149	putative active site [active]
1225522009150	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1225522009151	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
1225522009152	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1225522009153	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
1225522009154	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1225522009155	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
1225522009156	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1225522009157	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
1225522009158	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1225522009159	Walker A/P-loop; other site
1225522009160	ATP binding site [chemical binding]; other site
1225522009161	Q-loop/lid; other site
1225522009162	ABC transporter signature motif; other site
1225522009163	Walker B; other site
1225522009164	D-loop; other site
1225522009165	H-loop/switch region; other site
1225522009166	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1225522009167	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1225522009168	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1225522009169	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1225522009170	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1225522009171	30S subunit binding site; other site
1225522009172	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522009173	active site
1225522009174	phosphorylation site [posttranslational modification]
1225522009175	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
1225522009176	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1225522009177	dimerization domain swap beta strand [polypeptide binding]; other site
1225522009178	regulatory protein interface [polypeptide binding]; other site
1225522009179	active site
1225522009180	regulatory phosphorylation site [posttranslational modification]; other site
1225522009181	hypothetical protein; Provisional; Region: PRK10345
1225522009182	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1225522009183	Transglycosylase; Region: Transgly; cl17702
1225522009184	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1225522009185	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1225522009186	conserved cys residue [active]
1225522009187	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
1225522009188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522009189	putative active site [active]
1225522009190	heme pocket [chemical binding]; other site
1225522009191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522009192	dimer interface [polypeptide binding]; other site
1225522009193	phosphorylation site [posttranslational modification]
1225522009194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522009195	ATP binding site [chemical binding]; other site
1225522009196	Mg2+ binding site [ion binding]; other site
1225522009197	G-X-G motif; other site
1225522009198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522009199	active site
1225522009200	phosphorylation site [posttranslational modification]
1225522009201	intermolecular recognition site; other site
1225522009202	dimerization interface [polypeptide binding]; other site
1225522009203	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1225522009204	putative binding surface; other site
1225522009205	active site
1225522009206	radical SAM protein, TIGR01212 family; Region: TIGR01212
1225522009207	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522009208	FeS/SAM binding site; other site
1225522009209	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1225522009210	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1225522009211	active site
1225522009212	dimer interface [polypeptide binding]; other site
1225522009213	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1225522009214	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1225522009215	active site
1225522009216	FMN binding site [chemical binding]; other site
1225522009217	substrate binding site [chemical binding]; other site
1225522009218	3Fe-4S cluster binding site [ion binding]; other site
1225522009219	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1225522009220	domain interface; other site
1225522009221	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1225522009222	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522009223	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522009224	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1225522009225	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1225522009226	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
1225522009227	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1225522009228	Na binding site [ion binding]; other site
1225522009229	putative substrate binding site [chemical binding]; other site
1225522009230	cytosine deaminase; Provisional; Region: PRK09230
1225522009231	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1225522009232	active site
1225522009233	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1225522009234	N-acetylmannosamine kinase; Provisional; Region: PRK05082
1225522009235	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522009236	nucleotide binding site [chemical binding]; other site
1225522009237	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
1225522009238	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1225522009239	putative active site cavity [active]
1225522009240	putative sialic acid transporter; Provisional; Region: PRK03893
1225522009241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522009242	putative substrate translocation pore; other site
1225522009243	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1225522009244	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1225522009245	inhibitor site; inhibition site
1225522009246	active site
1225522009247	dimer interface [polypeptide binding]; other site
1225522009248	catalytic residue [active]
1225522009249	transcriptional regulator NanR; Provisional; Region: PRK03837
1225522009250	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522009251	DNA-binding site [nucleotide binding]; DNA binding site
1225522009252	FCD domain; Region: FCD; pfam07729
1225522009253	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
1225522009254	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1225522009255	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1225522009256	C-terminal domain interface [polypeptide binding]; other site
1225522009257	putative GSH binding site (G-site) [chemical binding]; other site
1225522009258	dimer interface [polypeptide binding]; other site
1225522009259	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1225522009260	dimer interface [polypeptide binding]; other site
1225522009261	N-terminal domain interface [polypeptide binding]; other site
1225522009262	Family of unknown function (DUF695); Region: DUF695; pfam05117
1225522009263	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
1225522009264	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1225522009265	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1225522009266	23S rRNA interface [nucleotide binding]; other site
1225522009267	L3 interface [polypeptide binding]; other site
1225522009268	Predicted ATPase [General function prediction only]; Region: COG1485
1225522009269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
1225522009270	hypothetical protein; Provisional; Region: PRK11677
1225522009271	serine endoprotease; Provisional; Region: PRK10139
1225522009272	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1225522009273	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1225522009274	protein binding site [polypeptide binding]; other site
1225522009275	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1225522009276	serine endoprotease; Provisional; Region: PRK10898
1225522009277	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1225522009278	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1225522009279	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
1225522009280	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
1225522009281	oxaloacetate decarboxylase; Provisional; Region: PRK14040
1225522009282	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1225522009283	active site
1225522009284	catalytic residues [active]
1225522009285	metal binding site [ion binding]; metal-binding site
1225522009286	homodimer binding site [polypeptide binding]; other site
1225522009287	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1225522009288	carboxyltransferase (CT) interaction site; other site
1225522009289	biotinylation site [posttranslational modification]; other site
1225522009290	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
1225522009291	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
1225522009292	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
1225522009293	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1225522009294	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1225522009295	transmembrane helices; other site
1225522009296	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1225522009297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522009298	DNA-binding site [nucleotide binding]; DNA binding site
1225522009299	FCD domain; Region: FCD; pfam07729
1225522009300	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1225522009301	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522009302	DNA-binding site [nucleotide binding]; DNA binding site
1225522009303	malate dehydrogenase; Provisional; Region: PRK05086
1225522009304	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
1225522009305	NAD binding site [chemical binding]; other site
1225522009306	dimerization interface [polypeptide binding]; other site
1225522009307	Substrate binding site [chemical binding]; other site
1225522009308	arginine repressor; Provisional; Region: PRK05066
1225522009309	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1225522009310	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1225522009311	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522009312	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522009313	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1225522009314	RNAase interaction site [polypeptide binding]; other site
1225522009315	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
1225522009316	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1225522009317	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1225522009318	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522009319	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522009320	efflux system membrane protein; Provisional; Region: PRK11594
1225522009321	transcriptional regulator; Provisional; Region: PRK10632
1225522009322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522009323	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1225522009324	putative effector binding pocket; other site
1225522009325	dimerization interface [polypeptide binding]; other site
1225522009326	protease TldD; Provisional; Region: tldD; PRK10735
1225522009327	hypothetical protein; Provisional; Region: PRK10899
1225522009328	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1225522009329	ribonuclease G; Provisional; Region: PRK11712
1225522009330	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1225522009331	homodimer interface [polypeptide binding]; other site
1225522009332	oligonucleotide binding site [chemical binding]; other site
1225522009333	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1225522009334	Maf-like protein; Region: Maf; pfam02545
1225522009335	active site
1225522009336	dimer interface [polypeptide binding]; other site
1225522009337	rod shape-determining protein MreD; Provisional; Region: PRK11060
1225522009338	rod shape-determining protein MreC; Region: mreC; TIGR00219
1225522009339	rod shape-determining protein MreC; Region: MreC; pfam04085
1225522009340	rod shape-determining protein MreB; Provisional; Region: PRK13927
1225522009341	MreB and similar proteins; Region: MreB_like; cd10225
1225522009342	nucleotide binding site [chemical binding]; other site
1225522009343	Mg binding site [ion binding]; other site
1225522009344	putative protofilament interaction site [polypeptide binding]; other site
1225522009345	RodZ interaction site [polypeptide binding]; other site
1225522009346	regulatory protein CsrD; Provisional; Region: PRK11059
1225522009347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522009348	metal binding site [ion binding]; metal-binding site
1225522009349	active site
1225522009350	I-site; other site
1225522009351	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522009352	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1225522009353	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1225522009354	NADP binding site [chemical binding]; other site
1225522009355	dimer interface [polypeptide binding]; other site
1225522009356	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1225522009357	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
1225522009358	Moco binding site; other site
1225522009359	metal coordination site [ion binding]; other site
1225522009360	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1225522009361	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1225522009362	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1225522009363	carboxyltransferase (CT) interaction site; other site
1225522009364	biotinylation site [posttranslational modification]; other site
1225522009365	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1225522009366	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1225522009367	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1225522009368	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1225522009369	hypothetical protein; Provisional; Region: PRK10633
1225522009370	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1225522009371	Na binding site [ion binding]; other site
1225522009372	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
1225522009373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1225522009374	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
1225522009375	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1225522009376	FMN binding site [chemical binding]; other site
1225522009377	active site
1225522009378	catalytic residues [active]
1225522009379	substrate binding site [chemical binding]; other site
1225522009380	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
1225522009381	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1225522009382	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1225522009383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522009384	DNA methylase; Region: N6_N4_Mtase; pfam01555
1225522009385	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
1225522009386	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1225522009387	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1225522009388	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1225522009389	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522009390	metal binding site [ion binding]; metal-binding site
1225522009391	active site
1225522009392	I-site; other site
1225522009393	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522009394	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
1225522009395	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522009396	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1225522009397	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1225522009398	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522009399	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522009400	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1225522009401	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1225522009402	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1225522009403	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1225522009404	purine monophosphate binding site [chemical binding]; other site
1225522009405	dimer interface [polypeptide binding]; other site
1225522009406	putative catalytic residues [active]
1225522009407	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1225522009408	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1225522009409	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1225522009410	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1225522009411	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1225522009412	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
1225522009413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522009414	active site
1225522009415	phosphorylation site [posttranslational modification]
1225522009416	intermolecular recognition site; other site
1225522009417	dimerization interface [polypeptide binding]; other site
1225522009418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522009419	Walker A motif; other site
1225522009420	ATP binding site [chemical binding]; other site
1225522009421	Walker B motif; other site
1225522009422	arginine finger; other site
1225522009423	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1225522009424	sensor protein ZraS; Provisional; Region: PRK10364
1225522009425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522009426	dimer interface [polypeptide binding]; other site
1225522009427	phosphorylation site [posttranslational modification]
1225522009428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522009429	ATP binding site [chemical binding]; other site
1225522009430	Mg2+ binding site [ion binding]; other site
1225522009431	G-X-G motif; other site
1225522009432	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1225522009433	dimer interface [polypeptide binding]; other site
1225522009434	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1225522009435	IHF dimer interface [polypeptide binding]; other site
1225522009436	IHF - DNA interface [nucleotide binding]; other site
1225522009437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
1225522009438	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1225522009439	Active_site [active]
1225522009440	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1225522009441	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1225522009442	substrate binding site [chemical binding]; other site
1225522009443	active site
1225522009444	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
1225522009445	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1225522009446	ThiC-associated domain; Region: ThiC-associated; pfam13667
1225522009447	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1225522009448	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1225522009449	thiamine phosphate binding site [chemical binding]; other site
1225522009450	active site
1225522009451	pyrophosphate binding site [ion binding]; other site
1225522009452	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1225522009453	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
1225522009454	ATP binding site [chemical binding]; other site
1225522009455	substrate interface [chemical binding]; other site
1225522009456	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1225522009457	thiS-thiF/thiG interaction site; other site
1225522009458	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1225522009459	ThiS interaction site; other site
1225522009460	putative active site [active]
1225522009461	tetramer interface [polypeptide binding]; other site
1225522009462	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
1225522009463	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522009464	FeS/SAM binding site; other site
1225522009465	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1225522009466	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1225522009467	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1225522009468	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1225522009469	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1225522009470	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1225522009471	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1225522009472	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1225522009473	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1225522009474	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1225522009475	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1225522009476	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1225522009477	DNA binding site [nucleotide binding]
1225522009478	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1225522009479	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1225522009480	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1225522009481	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1225522009482	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1225522009483	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1225522009484	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1225522009485	RPB3 interaction site [polypeptide binding]; other site
1225522009486	RPB1 interaction site [polypeptide binding]; other site
1225522009487	RPB11 interaction site [polypeptide binding]; other site
1225522009488	RPB10 interaction site [polypeptide binding]; other site
1225522009489	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1225522009490	core dimer interface [polypeptide binding]; other site
1225522009491	peripheral dimer interface [polypeptide binding]; other site
1225522009492	L10 interface [polypeptide binding]; other site
1225522009493	L11 interface [polypeptide binding]; other site
1225522009494	putative EF-Tu interaction site [polypeptide binding]; other site
1225522009495	putative EF-G interaction site [polypeptide binding]; other site
1225522009496	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1225522009497	23S rRNA interface [nucleotide binding]; other site
1225522009498	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1225522009499	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1225522009500	mRNA/rRNA interface [nucleotide binding]; other site
1225522009501	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1225522009502	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1225522009503	L7/L12 interface [polypeptide binding]; other site
1225522009504	23S rRNA interface [nucleotide binding]; other site
1225522009505	L25 interface [polypeptide binding]; other site
1225522009506	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1225522009507	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1225522009508	putative homodimer interface [polypeptide binding]; other site
1225522009509	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1225522009510	heterodimer interface [polypeptide binding]; other site
1225522009511	homodimer interface [polypeptide binding]; other site
1225522009512	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1225522009513	elongation factor Tu; Reviewed; Region: PRK00049
1225522009514	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1225522009515	G1 box; other site
1225522009516	GEF interaction site [polypeptide binding]; other site
1225522009517	GTP/Mg2+ binding site [chemical binding]; other site
1225522009518	Switch I region; other site
1225522009519	G2 box; other site
1225522009520	G3 box; other site
1225522009521	Switch II region; other site
1225522009522	G4 box; other site
1225522009523	G5 box; other site
1225522009524	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1225522009525	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1225522009526	Antibiotic Binding Site [chemical binding]; other site
1225522009527	pantothenate kinase; Provisional; Region: PRK05439
1225522009528	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1225522009529	ATP-binding site [chemical binding]; other site
1225522009530	CoA-binding site [chemical binding]; other site
1225522009531	Mg2+-binding site [ion binding]; other site
1225522009532	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1225522009533	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1225522009534	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1225522009535	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1225522009536	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1225522009537	FAD binding domain; Region: FAD_binding_4; pfam01565
1225522009538	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1225522009539	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
1225522009540	potassium transporter; Provisional; Region: PRK10750
1225522009541	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1225522009542	hypothetical protein; Provisional; Region: PRK11568
1225522009543	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1225522009544	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1225522009545	proline dipeptidase; Provisional; Region: PRK13607
1225522009546	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1225522009547	active site
1225522009548	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1225522009549	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1225522009550	substrate binding site [chemical binding]; other site
1225522009551	oxyanion hole (OAH) forming residues; other site
1225522009552	trimer interface [polypeptide binding]; other site
1225522009553	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1225522009554	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1225522009555	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1225522009556	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1225522009557	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1225522009558	dimer interface [polypeptide binding]; other site
1225522009559	active site
1225522009560	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
1225522009561	FMN reductase; Validated; Region: fre; PRK08051
1225522009562	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1225522009563	FAD binding pocket [chemical binding]; other site
1225522009564	FAD binding motif [chemical binding]; other site
1225522009565	phosphate binding motif [ion binding]; other site
1225522009566	beta-alpha-beta structure motif; other site
1225522009567	NAD binding pocket [chemical binding]; other site
1225522009568	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
1225522009569	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
1225522009570	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
1225522009571	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
1225522009572	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1225522009573	active site
1225522009574	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
1225522009575	sec-independent translocase; Provisional; Region: PRK01770
1225522009576	sec-independent translocase; Provisional; Region: tatB; PRK00404
1225522009577	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
1225522009578	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1225522009579	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1225522009580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1225522009581	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1225522009582	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1225522009583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522009584	S-adenosylmethionine binding site [chemical binding]; other site
1225522009585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1225522009586	DNA recombination protein RmuC; Provisional; Region: PRK10361
1225522009587	RmuC family; Region: RmuC; pfam02646
1225522009588	uridine phosphorylase; Provisional; Region: PRK11178
1225522009589	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
1225522009590	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1225522009591	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1225522009592	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522009593	FeS/SAM binding site; other site
1225522009594	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1225522009595	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1225522009596	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1225522009597	THF binding site; other site
1225522009598	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1225522009599	substrate binding site [chemical binding]; other site
1225522009600	THF binding site; other site
1225522009601	zinc-binding site [ion binding]; other site
1225522009602	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1225522009603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522009604	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1225522009605	putative dimerization interface [polypeptide binding]; other site
1225522009606	putative hydrolase; Provisional; Region: PRK10976
1225522009607	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522009608	active site
1225522009609	motif I; other site
1225522009610	motif II; other site
1225522009611	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522009612	lysophospholipase L2; Provisional; Region: PRK10749
1225522009613	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1225522009614	threonine efflux system; Provisional; Region: PRK10229
1225522009615	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
1225522009616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522009617	ATP binding site [chemical binding]; other site
1225522009618	putative Mg++ binding site [ion binding]; other site
1225522009619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522009620	nucleotide binding region [chemical binding]; other site
1225522009621	ATP-binding site [chemical binding]; other site
1225522009622	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1225522009623	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1225522009624	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1225522009625	dimerization interface [polypeptide binding]; other site
1225522009626	substrate binding site [chemical binding]; other site
1225522009627	active site
1225522009628	calcium binding site [ion binding]; other site
1225522009629	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1225522009630	CoenzymeA binding site [chemical binding]; other site
1225522009631	subunit interaction site [polypeptide binding]; other site
1225522009632	PHB binding site; other site
1225522009633	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
1225522009634	EamA-like transporter family; Region: EamA; cl17759
1225522009635	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1225522009636	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1225522009637	Cl binding site [ion binding]; other site
1225522009638	oligomer interface [polypeptide binding]; other site
1225522009639	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1225522009640	Part of AAA domain; Region: AAA_19; pfam13245
1225522009641	Family description; Region: UvrD_C_2; pfam13538
1225522009642	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1225522009643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522009644	motif II; other site
1225522009645	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
1225522009646	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1225522009647	active site
1225522009648	Int/Topo IB signature motif; other site
1225522009649	hypothetical protein; Provisional; Region: PRK10963
1225522009650	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1225522009651	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1225522009652	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1225522009653	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
1225522009654	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1225522009655	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
1225522009656	putative iron binding site [ion binding]; other site
1225522009657	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
1225522009658	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1225522009659	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1225522009660	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1225522009661	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1225522009662	domain interfaces; other site
1225522009663	active site
1225522009664	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1225522009665	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1225522009666	active site
1225522009667	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1225522009668	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
1225522009669	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
1225522009670	HemY protein N-terminus; Region: HemY_N; pfam07219
1225522009671	putative transport protein YifK; Provisional; Region: PRK10746
1225522009672	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1225522009673	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1225522009674	putative common antigen polymerase; Provisional; Region: PRK02975
1225522009675	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
1225522009676	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1225522009677	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
1225522009678	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1225522009679	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1225522009680	inhibitor-cofactor binding pocket; inhibition site
1225522009681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522009682	catalytic residue [active]
1225522009683	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
1225522009684	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1225522009685	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1225522009686	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
1225522009687	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1225522009688	NAD binding site [chemical binding]; other site
1225522009689	substrate binding site [chemical binding]; other site
1225522009690	homodimer interface [polypeptide binding]; other site
1225522009691	active site
1225522009692	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
1225522009693	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1225522009694	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1225522009695	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1225522009696	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1225522009697	homodimer interface [polypeptide binding]; other site
1225522009698	active site
1225522009699	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
1225522009700	Chain length determinant protein; Region: Wzz; pfam02706
1225522009701	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
1225522009702	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1225522009703	Mg++ binding site [ion binding]; other site
1225522009704	putative catalytic motif [active]
1225522009705	substrate binding site [chemical binding]; other site
1225522009706	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1225522009707	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1225522009708	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1225522009709	RNA binding site [nucleotide binding]; other site
1225522009710	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1225522009711	multimer interface [polypeptide binding]; other site
1225522009712	Walker A motif; other site
1225522009713	ATP binding site [chemical binding]; other site
1225522009714	Walker B motif; other site
1225522009715	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1225522009716	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1225522009717	catalytic residues [active]
1225522009718	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1225522009719	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1225522009720	ATP binding site [chemical binding]; other site
1225522009721	Mg++ binding site [ion binding]; other site
1225522009722	motif III; other site
1225522009723	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522009724	nucleotide binding region [chemical binding]; other site
1225522009725	ATP-binding site [chemical binding]; other site
1225522009726	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
1225522009727	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1225522009728	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
1225522009729	Part of AAA domain; Region: AAA_19; pfam13245
1225522009730	Family description; Region: UvrD_C_2; pfam13538
1225522009731	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
1225522009732	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1225522009733	ketol-acid reductoisomerase; Validated; Region: PRK05225
1225522009734	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1225522009735	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1225522009736	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1225522009737	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522009738	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
1225522009739	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
1225522009740	putative dimerization interface [polypeptide binding]; other site
1225522009741	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
1225522009742	Phage-related protein [Function unknown]; Region: COG4679
1225522009743	threonine dehydratase; Reviewed; Region: PRK09224
1225522009744	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1225522009745	tetramer interface [polypeptide binding]; other site
1225522009746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522009747	catalytic residue [active]
1225522009748	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1225522009749	putative Ile/Val binding site [chemical binding]; other site
1225522009750	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1225522009751	putative Ile/Val binding site [chemical binding]; other site
1225522009752	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1225522009753	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1225522009754	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1225522009755	homodimer interface [polypeptide binding]; other site
1225522009756	substrate-cofactor binding pocket; other site
1225522009757	catalytic residue [active]
1225522009758	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
1225522009759	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
1225522009760	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1225522009761	PYR/PP interface [polypeptide binding]; other site
1225522009762	dimer interface [polypeptide binding]; other site
1225522009763	TPP binding site [chemical binding]; other site
1225522009764	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1225522009765	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1225522009766	TPP-binding site [chemical binding]; other site
1225522009767	dimer interface [polypeptide binding]; other site
1225522009768	putative ATP-dependent protease; Provisional; Region: PRK09862
1225522009769	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1225522009770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522009771	Walker A motif; other site
1225522009772	ATP binding site [chemical binding]; other site
1225522009773	Walker B motif; other site
1225522009774	arginine finger; other site
1225522009775	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1225522009776	hypothetical protein; Provisional; Region: PRK11027
1225522009777	transcriptional regulator HdfR; Provisional; Region: PRK03601
1225522009778	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522009779	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1225522009780	dimerization interface [polypeptide binding]; other site
1225522009781	glutamate racemase; Provisional; Region: PRK00865
1225522009782	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
1225522009783	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1225522009784	N-terminal plug; other site
1225522009785	ligand-binding site [chemical binding]; other site
1225522009786	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1225522009787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522009788	S-adenosylmethionine binding site [chemical binding]; other site
1225522009789	hypothetical protein; Provisional; Region: PRK11056
1225522009790	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1225522009791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522009792	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1225522009793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522009794	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1225522009795	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1225522009796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522009797	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1225522009798	dimerization interface [polypeptide binding]; other site
1225522009799	argininosuccinate lyase; Provisional; Region: PRK04833
1225522009800	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1225522009801	active sites [active]
1225522009802	tetramer interface [polypeptide binding]; other site
1225522009803	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
1225522009804	nucleotide binding site [chemical binding]; other site
1225522009805	N-acetyl-L-glutamate binding site [chemical binding]; other site
1225522009806	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1225522009807	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1225522009808	acetylornithine deacetylase; Provisional; Region: PRK05111
1225522009809	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1225522009810	metal binding site [ion binding]; metal-binding site
1225522009811	putative dimer interface [polypeptide binding]; other site
1225522009812	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1225522009813	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1225522009814	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522009815	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522009816	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1225522009817	active site
1225522009818	P-loop; other site
1225522009819	phosphorylation site [posttranslational modification]
1225522009820	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522009821	FeS/SAM binding site; other site
1225522009822	pyruvate formate lyase II activase; Provisional; Region: PRK10076
1225522009823	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
1225522009824	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1225522009825	dimer interface [polypeptide binding]; other site
1225522009826	active site
1225522009827	glycine loop; other site
1225522009828	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1225522009829	active site
1225522009830	P-loop; other site
1225522009831	phosphorylation site [posttranslational modification]
1225522009832	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
1225522009833	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1225522009834	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1225522009835	dimerization domain swap beta strand [polypeptide binding]; other site
1225522009836	regulatory protein interface [polypeptide binding]; other site
1225522009837	active site
1225522009838	regulatory phosphorylation site [posttranslational modification]; other site
1225522009839	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1225522009840	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1225522009841	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1225522009842	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1225522009843	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522009844	active site
1225522009845	phosphorylation site [posttranslational modification]
1225522009846	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1225522009847	active site
1225522009848	intersubunit interactions; other site
1225522009849	catalytic residue [active]
1225522009850	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1225522009851	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1225522009852	dimer interface [polypeptide binding]; other site
1225522009853	active site
1225522009854	metal binding site [ion binding]; metal-binding site
1225522009855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
1225522009856	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1225522009857	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1225522009858	heme binding site [chemical binding]; other site
1225522009859	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1225522009860	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1225522009861	FAD binding site [chemical binding]; other site
1225522009862	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1225522009863	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522009864	DNA-binding site [nucleotide binding]; DNA binding site
1225522009865	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522009866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522009867	homodimer interface [polypeptide binding]; other site
1225522009868	catalytic residue [active]
1225522009869	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
1225522009870	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1225522009871	dimer interface [polypeptide binding]; other site
1225522009872	active site
1225522009873	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1225522009874	folate binding site [chemical binding]; other site
1225522009875	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1225522009876	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1225522009877	active site
1225522009878	metal binding site [ion binding]; metal-binding site
1225522009879	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1225522009880	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1225522009881	mechanosensitive channel MscS; Provisional; Region: PRK10334
1225522009882	Conserved TM helix; Region: TM_helix; pfam05552
1225522009883	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522009884	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
1225522009885	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1225522009886	putative catalytic residues [active]
1225522009887	putative nucleotide binding site [chemical binding]; other site
1225522009888	putative aspartate binding site [chemical binding]; other site
1225522009889	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
1225522009890	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1225522009891	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1225522009892	cystathionine gamma-synthase; Provisional; Region: PRK08045
1225522009893	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1225522009894	homodimer interface [polypeptide binding]; other site
1225522009895	substrate-cofactor binding pocket; other site
1225522009896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522009897	catalytic residue [active]
1225522009898	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
1225522009899	dimerization interface [polypeptide binding]; other site
1225522009900	DNA binding site [nucleotide binding]
1225522009901	corepressor binding sites; other site
1225522009902	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
1225522009903	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
1225522009904	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1225522009905	primosome assembly protein PriA; Validated; Region: PRK05580
1225522009906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522009907	ATP binding site [chemical binding]; other site
1225522009908	putative Mg++ binding site [ion binding]; other site
1225522009909	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1225522009910	ATP-binding site [chemical binding]; other site
1225522009911	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522009912	DNA binding site [nucleotide binding]
1225522009913	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1225522009914	domain linker motif; other site
1225522009915	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1225522009916	dimerization interface [polypeptide binding]; other site
1225522009917	ligand binding site [chemical binding]; other site
1225522009918	essential cell division protein FtsN; Provisional; Region: PRK10927
1225522009919	cell division protein FtsN; Provisional; Region: PRK12757
1225522009920	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1225522009921	active site
1225522009922	HslU subunit interaction site [polypeptide binding]; other site
1225522009923	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1225522009924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522009925	Walker A motif; other site
1225522009926	ATP binding site [chemical binding]; other site
1225522009927	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1225522009928	Walker B motif; other site
1225522009929	arginine finger; other site
1225522009930	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1225522009931	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
1225522009932	UbiA prenyltransferase family; Region: UbiA; pfam01040
1225522009933	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1225522009934	septal ring assembly protein ZapB; Provisional; Region: PRK15422
1225522009935	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1225522009936	amphipathic channel; other site
1225522009937	Asn-Pro-Ala signature motifs; other site
1225522009938	glycerol kinase; Provisional; Region: glpK; PRK00047
1225522009939	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1225522009940	N- and C-terminal domain interface [polypeptide binding]; other site
1225522009941	active site
1225522009942	MgATP binding site [chemical binding]; other site
1225522009943	catalytic site [active]
1225522009944	metal binding site [ion binding]; metal-binding site
1225522009945	glycerol binding site [chemical binding]; other site
1225522009946	homotetramer interface [polypeptide binding]; other site
1225522009947	homodimer interface [polypeptide binding]; other site
1225522009948	FBP binding site [chemical binding]; other site
1225522009949	protein IIAGlc interface [polypeptide binding]; other site
1225522009950	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1225522009951	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1225522009952	putative active site [active]
1225522009953	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1225522009954	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1225522009955	FAD binding pocket [chemical binding]; other site
1225522009956	FAD binding motif [chemical binding]; other site
1225522009957	phosphate binding motif [ion binding]; other site
1225522009958	beta-alpha-beta structure motif; other site
1225522009959	NAD binding pocket [chemical binding]; other site
1225522009960	Predicted membrane protein [Function unknown]; Region: COG3152
1225522009961	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
1225522009962	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1225522009963	triosephosphate isomerase; Provisional; Region: PRK14567
1225522009964	substrate binding site [chemical binding]; other site
1225522009965	dimer interface [polypeptide binding]; other site
1225522009966	catalytic triad [active]
1225522009967	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1225522009968	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1225522009969	substrate binding site [chemical binding]; other site
1225522009970	hexamer interface [polypeptide binding]; other site
1225522009971	metal binding site [ion binding]; metal-binding site
1225522009972	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
1225522009973	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
1225522009974	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1225522009975	putative active site; other site
1225522009976	catalytic residue [active]
1225522009977	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
1225522009978	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1225522009979	ligand binding site [chemical binding]; other site
1225522009980	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1225522009981	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1225522009982	TM-ABC transporter signature motif; other site
1225522009983	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1225522009984	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1225522009985	TM-ABC transporter signature motif; other site
1225522009986	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
1225522009987	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1225522009988	Walker A/P-loop; other site
1225522009989	ATP binding site [chemical binding]; other site
1225522009990	Q-loop/lid; other site
1225522009991	ABC transporter signature motif; other site
1225522009992	Walker B; other site
1225522009993	D-loop; other site
1225522009994	H-loop/switch region; other site
1225522009995	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1225522009996	transcriptional regulator LsrR; Provisional; Region: PRK15418
1225522009997	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1225522009998	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1225522009999	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1225522010000	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
1225522010001	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1225522010002	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522010003	DNA-binding site [nucleotide binding]; DNA binding site
1225522010004	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
1225522010005	UTRA domain; Region: UTRA; pfam07702
1225522010006	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
1225522010007	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522010008	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1225522010009	putative substrate binding site [chemical binding]; other site
1225522010010	putative ATP binding site [chemical binding]; other site
1225522010011	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1225522010012	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1225522010013	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
1225522010014	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1225522010015	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522010016	substrate binding pocket [chemical binding]; other site
1225522010017	membrane-bound complex binding site; other site
1225522010018	hinge residues; other site
1225522010019	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1225522010020	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1225522010021	active site
1225522010022	ADP/pyrophosphate binding site [chemical binding]; other site
1225522010023	dimerization interface [polypeptide binding]; other site
1225522010024	allosteric effector site; other site
1225522010025	fructose-1,6-bisphosphate binding site; other site
1225522010026	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
1225522010027	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1225522010028	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1225522010029	dimer interface [polypeptide binding]; other site
1225522010030	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
1225522010031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522010032	active site
1225522010033	intermolecular recognition site; other site
1225522010034	dimerization interface [polypeptide binding]; other site
1225522010035	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522010036	DNA binding site [nucleotide binding]
1225522010037	two-component sensor protein; Provisional; Region: cpxA; PRK09470
1225522010038	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522010039	dimerization interface [polypeptide binding]; other site
1225522010040	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522010041	dimer interface [polypeptide binding]; other site
1225522010042	phosphorylation site [posttranslational modification]
1225522010043	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522010044	ATP binding site [chemical binding]; other site
1225522010045	Mg2+ binding site [ion binding]; other site
1225522010046	G-X-G motif; other site
1225522010047	SnoaL-like domain; Region: SnoaL_2; pfam12680
1225522010048	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
1225522010049	MOSC domain; Region: MOSC; pfam03473
1225522010050	3-alpha domain; Region: 3-alpha; pfam03475
1225522010051	superoxide dismutase; Provisional; Region: PRK10925
1225522010052	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1225522010053	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1225522010054	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1225522010055	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1225522010056	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1225522010057	DctM-like transporters; Region: DctM; pfam06808
1225522010058	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1225522010059	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
1225522010060	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
1225522010061	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
1225522010062	transcriptional activator RhaR; Provisional; Region: PRK13502
1225522010063	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1225522010064	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522010065	transcriptional activator RhaS; Provisional; Region: PRK13503
1225522010066	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1225522010067	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522010068	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522010069	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1225522010070	N- and C-terminal domain interface [polypeptide binding]; other site
1225522010071	active site
1225522010072	putative catalytic site [active]
1225522010073	metal binding site [ion binding]; metal-binding site
1225522010074	ATP binding site [chemical binding]; other site
1225522010075	rhamnulokinase; Provisional; Region: rhaB; PRK10640
1225522010076	carbohydrate binding site [chemical binding]; other site
1225522010077	L-rhamnose isomerase; Provisional; Region: PRK01076
1225522010078	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1225522010079	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1225522010080	intersubunit interface [polypeptide binding]; other site
1225522010081	active site
1225522010082	Zn2+ binding site [ion binding]; other site
1225522010083	lactaldehyde reductase; Region: lactal_redase; TIGR02638
1225522010084	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1225522010085	dimer interface [polypeptide binding]; other site
1225522010086	active site
1225522010087	metal binding site [ion binding]; metal-binding site
1225522010088	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
1225522010089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522010090	non-specific DNA binding site [nucleotide binding]; other site
1225522010091	salt bridge; other site
1225522010092	sequence-specific DNA binding site [nucleotide binding]; other site
1225522010093	Cupin domain; Region: Cupin_2; cl17218
1225522010094	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1225522010095	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1225522010096	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
1225522010097	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1225522010098	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1225522010099	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1225522010100	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
1225522010101	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1225522010102	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
1225522010103	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
1225522010104	Predicted transcriptional regulator [Transcription]; Region: COG2944
1225522010105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522010106	non-specific DNA binding site [nucleotide binding]; other site
1225522010107	salt bridge; other site
1225522010108	sequence-specific DNA binding site [nucleotide binding]; other site
1225522010109	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1225522010110	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1225522010111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
1225522010112	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522010113	non-specific DNA binding site [nucleotide binding]; other site
1225522010114	salt bridge; other site
1225522010115	sequence-specific DNA binding site [nucleotide binding]; other site
1225522010116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522010117	Coenzyme A binding pocket [chemical binding]; other site
1225522010118	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1225522010119	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1225522010120	putative active site [active]
1225522010121	dimerization interface [polypeptide binding]; other site
1225522010122	putative tRNAtyr binding site [nucleotide binding]; other site
1225522010123	hypothetical protein; Reviewed; Region: PRK01637
1225522010124	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1225522010125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010126	motif II; other site
1225522010127	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522010128	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522010129	putative DNA binding site [nucleotide binding]; other site
1225522010130	putative Zn2+ binding site [ion binding]; other site
1225522010131	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522010132	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522010133	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
1225522010134	substrate binding site [chemical binding]; other site
1225522010135	ATP binding site [chemical binding]; other site
1225522010136	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
1225522010137	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1225522010138	Class I aldolases; Region: Aldolase_Class_I; cl17187
1225522010139	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1225522010140	dimerization interface [polypeptide binding]; other site
1225522010141	putative active cleft [active]
1225522010142	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1225522010143	active site
1225522010144	catalytic residues [active]
1225522010145	alpha-glucosidase; Provisional; Region: PRK10426
1225522010146	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1225522010147	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
1225522010148	putative active site [active]
1225522010149	putative catalytic site [active]
1225522010150	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1225522010151	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1225522010152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010153	putative substrate translocation pore; other site
1225522010154	outer membrane porin L; Provisional; Region: ompL; PRK09980
1225522010155	Sulfatase; Region: Sulfatase; cl17466
1225522010156	coproporphyrinogen III oxidase; Validated; Region: PRK08208
1225522010157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522010158	FeS/SAM binding site; other site
1225522010159	HemN C-terminal domain; Region: HemN_C; pfam06969
1225522010160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010161	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1225522010162	active site
1225522010163	motif I; other site
1225522010164	motif II; other site
1225522010165	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010166	GTP-binding protein; Provisional; Region: PRK10218
1225522010167	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1225522010168	G1 box; other site
1225522010169	putative GEF interaction site [polypeptide binding]; other site
1225522010170	GTP/Mg2+ binding site [chemical binding]; other site
1225522010171	Switch I region; other site
1225522010172	G2 box; other site
1225522010173	G3 box; other site
1225522010174	Switch II region; other site
1225522010175	G4 box; other site
1225522010176	G5 box; other site
1225522010177	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1225522010178	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1225522010179	glutamine synthetase; Provisional; Region: glnA; PRK09469
1225522010180	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1225522010181	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1225522010182	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
1225522010183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1225522010184	putative active site [active]
1225522010185	heme pocket [chemical binding]; other site
1225522010186	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522010187	dimer interface [polypeptide binding]; other site
1225522010188	phosphorylation site [posttranslational modification]
1225522010189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522010190	ATP binding site [chemical binding]; other site
1225522010191	Mg2+ binding site [ion binding]; other site
1225522010192	G-X-G motif; other site
1225522010193	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
1225522010194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522010195	active site
1225522010196	phosphorylation site [posttranslational modification]
1225522010197	intermolecular recognition site; other site
1225522010198	dimerization interface [polypeptide binding]; other site
1225522010199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522010200	Walker A motif; other site
1225522010201	ATP binding site [chemical binding]; other site
1225522010202	Walker B motif; other site
1225522010203	arginine finger; other site
1225522010204	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1225522010205	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1225522010206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522010207	FeS/SAM binding site; other site
1225522010208	HemN C-terminal domain; Region: HemN_C; pfam06969
1225522010209	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1225522010210	G1 box; other site
1225522010211	GTP/Mg2+ binding site [chemical binding]; other site
1225522010212	Switch I region; other site
1225522010213	G2 box; other site
1225522010214	G3 box; other site
1225522010215	Switch II region; other site
1225522010216	G4 box; other site
1225522010217	G5 box; other site
1225522010218	DNA polymerase I; Provisional; Region: PRK05755
1225522010219	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1225522010220	active site
1225522010221	metal binding site 1 [ion binding]; metal-binding site
1225522010222	putative 5' ssDNA interaction site; other site
1225522010223	metal binding site 3; metal-binding site
1225522010224	metal binding site 2 [ion binding]; metal-binding site
1225522010225	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1225522010226	putative DNA binding site [nucleotide binding]; other site
1225522010227	putative metal binding site [ion binding]; other site
1225522010228	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1225522010229	active site
1225522010230	catalytic site [active]
1225522010231	substrate binding site [chemical binding]; other site
1225522010232	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1225522010233	active site
1225522010234	DNA binding site [nucleotide binding]
1225522010235	catalytic site [active]
1225522010236	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1225522010237	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1225522010238	putative acyl-acceptor binding pocket; other site
1225522010239	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1225522010240	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1225522010241	catalytic residues [active]
1225522010242	hinge region; other site
1225522010243	alpha helical domain; other site
1225522010244	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1225522010245	serine/threonine protein kinase; Provisional; Region: PRK11768
1225522010246	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
1225522010247	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1225522010248	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1225522010249	GTP binding site; other site
1225522010250	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1225522010251	Walker A motif; other site
1225522010252	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1225522010253	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522010254	DNA-binding site [nucleotide binding]; DNA binding site
1225522010255	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1225522010256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010257	transcriptional repressor RbsR; Provisional; Region: PRK10423
1225522010258	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522010259	DNA binding site [nucleotide binding]
1225522010260	domain linker motif; other site
1225522010261	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1225522010262	dimerization interface [polypeptide binding]; other site
1225522010263	ligand binding site [chemical binding]; other site
1225522010264	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522010265	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1225522010266	substrate binding site [chemical binding]; other site
1225522010267	dimer interface [polypeptide binding]; other site
1225522010268	ATP binding site [chemical binding]; other site
1225522010269	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1225522010270	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1225522010271	ligand binding site [chemical binding]; other site
1225522010272	dimerization interface [polypeptide binding]; other site
1225522010273	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1225522010274	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1225522010275	TM-ABC transporter signature motif; other site
1225522010276	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
1225522010277	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1225522010278	Walker A/P-loop; other site
1225522010279	ATP binding site [chemical binding]; other site
1225522010280	Q-loop/lid; other site
1225522010281	ABC transporter signature motif; other site
1225522010282	Walker B; other site
1225522010283	D-loop; other site
1225522010284	H-loop/switch region; other site
1225522010285	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1225522010286	D-ribose pyranase; Provisional; Region: PRK11797
1225522010287	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
1225522010288	potassium uptake protein; Region: kup; TIGR00794
1225522010289	regulatory ATPase RavA; Provisional; Region: PRK13531
1225522010290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522010291	Walker A motif; other site
1225522010292	ATP binding site [chemical binding]; other site
1225522010293	Walker B motif; other site
1225522010294	arginine finger; other site
1225522010295	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
1225522010296	hypothetical protein; Provisional; Region: yieM; PRK10997
1225522010297	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
1225522010298	metal ion-dependent adhesion site (MIDAS); other site
1225522010299	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1225522010300	dimer interface [polypeptide binding]; other site
1225522010301	active site
1225522010302	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1225522010303	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1225522010304	putative DNA binding site [nucleotide binding]; other site
1225522010305	putative Zn2+ binding site [ion binding]; other site
1225522010306	AsnC family; Region: AsnC_trans_reg; pfam01037
1225522010307	FMN-binding protein MioC; Provisional; Region: PRK09004
1225522010308	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1225522010309	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1225522010310	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1225522010311	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1225522010312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522010313	S-adenosylmethionine binding site [chemical binding]; other site
1225522010314	ATP synthase I chain; Region: ATP_synt_I; cl09170
1225522010315	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1225522010316	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1225522010317	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1225522010318	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1225522010319	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1225522010320	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1225522010321	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1225522010322	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1225522010323	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1225522010324	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1225522010325	beta subunit interaction interface [polypeptide binding]; other site
1225522010326	Walker A motif; other site
1225522010327	ATP binding site [chemical binding]; other site
1225522010328	Walker B motif; other site
1225522010329	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1225522010330	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1225522010331	core domain interface [polypeptide binding]; other site
1225522010332	delta subunit interface [polypeptide binding]; other site
1225522010333	epsilon subunit interface [polypeptide binding]; other site
1225522010334	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1225522010335	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1225522010336	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1225522010337	alpha subunit interaction interface [polypeptide binding]; other site
1225522010338	Walker A motif; other site
1225522010339	ATP binding site [chemical binding]; other site
1225522010340	Walker B motif; other site
1225522010341	inhibitor binding site; inhibition site
1225522010342	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1225522010343	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1225522010344	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1225522010345	gamma subunit interface [polypeptide binding]; other site
1225522010346	epsilon subunit interface [polypeptide binding]; other site
1225522010347	LBP interface [polypeptide binding]; other site
1225522010348	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1225522010349	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1225522010350	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
1225522010351	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1225522010352	Substrate binding site; other site
1225522010353	Mg++ binding site; other site
1225522010354	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1225522010355	active site
1225522010356	substrate binding site [chemical binding]; other site
1225522010357	CoA binding site [chemical binding]; other site
1225522010358	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1225522010359	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1225522010360	glutaminase active site [active]
1225522010361	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1225522010362	dimer interface [polypeptide binding]; other site
1225522010363	active site
1225522010364	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1225522010365	dimer interface [polypeptide binding]; other site
1225522010366	active site
1225522010367	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1225522010368	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1225522010369	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1225522010370	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1225522010371	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1225522010372	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1225522010373	shikimate binding site; other site
1225522010374	NAD(P) binding site [chemical binding]; other site
1225522010375	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1225522010376	active site
1225522010377	P-loop; other site
1225522010378	phosphorylation site [posttranslational modification]
1225522010379	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
1225522010380	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1225522010381	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522010382	substrate binding pocket [chemical binding]; other site
1225522010383	membrane-bound complex binding site; other site
1225522010384	hinge residues; other site
1225522010385	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
1225522010386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522010387	dimer interface [polypeptide binding]; other site
1225522010388	conserved gate region; other site
1225522010389	putative PBP binding loops; other site
1225522010390	ABC-ATPase subunit interface; other site
1225522010391	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1225522010392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522010393	dimer interface [polypeptide binding]; other site
1225522010394	conserved gate region; other site
1225522010395	putative PBP binding loops; other site
1225522010396	ABC-ATPase subunit interface; other site
1225522010397	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1225522010398	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1225522010399	Walker A/P-loop; other site
1225522010400	ATP binding site [chemical binding]; other site
1225522010401	Q-loop/lid; other site
1225522010402	ABC transporter signature motif; other site
1225522010403	Walker B; other site
1225522010404	D-loop; other site
1225522010405	H-loop/switch region; other site
1225522010406	transcriptional regulator PhoU; Provisional; Region: PRK11115
1225522010407	PhoU domain; Region: PhoU; pfam01895
1225522010408	PhoU domain; Region: PhoU; pfam01895
1225522010409	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
1225522010410	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010411	active site
1225522010412	motif I; other site
1225522010413	motif II; other site
1225522010414	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1225522010415	Predicted flavoprotein [General function prediction only]; Region: COG0431
1225522010416	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1225522010417	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1225522010418	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
1225522010419	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522010420	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1225522010421	substrate binding pocket [chemical binding]; other site
1225522010422	dimerization interface [polypeptide binding]; other site
1225522010423	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
1225522010424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010425	putative substrate translocation pore; other site
1225522010426	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1225522010427	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1225522010428	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1225522010429	G1 box; other site
1225522010430	GTP/Mg2+ binding site [chemical binding]; other site
1225522010431	Switch I region; other site
1225522010432	G2 box; other site
1225522010433	Switch II region; other site
1225522010434	G3 box; other site
1225522010435	G4 box; other site
1225522010436	G5 box; other site
1225522010437	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1225522010438	membrane protein insertase; Provisional; Region: PRK01318
1225522010439	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1225522010440	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1225522010441	ribonuclease P; Reviewed; Region: rnpA; PRK01732
1225522010442	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1225522010443	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1225522010444	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1225522010445	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522010446	Walker A motif; other site
1225522010447	ATP binding site [chemical binding]; other site
1225522010448	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1225522010449	Walker B motif; other site
1225522010450	arginine finger; other site
1225522010451	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1225522010452	DnaA box-binding interface [nucleotide binding]; other site
1225522010453	DNA polymerase III subunit beta; Validated; Region: PRK05643
1225522010454	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1225522010455	putative DNA binding surface [nucleotide binding]; other site
1225522010456	dimer interface [polypeptide binding]; other site
1225522010457	beta-clamp/clamp loader binding surface; other site
1225522010458	beta-clamp/translesion DNA polymerase binding surface; other site
1225522010459	recF protein; Region: recf; TIGR00611
1225522010460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522010461	Walker A/P-loop; other site
1225522010462	ATP binding site [chemical binding]; other site
1225522010463	Q-loop/lid; other site
1225522010464	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522010465	ABC transporter signature motif; other site
1225522010466	Walker B; other site
1225522010467	D-loop; other site
1225522010468	H-loop/switch region; other site
1225522010469	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1225522010470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522010471	Mg2+ binding site [ion binding]; other site
1225522010472	G-X-G motif; other site
1225522010473	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1225522010474	anchoring element; other site
1225522010475	dimer interface [polypeptide binding]; other site
1225522010476	ATP binding site [chemical binding]; other site
1225522010477	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1225522010478	active site
1225522010479	putative metal-binding site [ion binding]; other site
1225522010480	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1225522010481	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522010482	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522010483	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1225522010484	putative dimerization interface [polypeptide binding]; other site
1225522010485	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1225522010486	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1225522010487	active site pocket [active]
1225522010488	sugar phosphate phosphatase; Provisional; Region: PRK10513
1225522010489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010490	active site
1225522010491	motif I; other site
1225522010492	motif II; other site
1225522010493	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010494	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1225522010495	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522010496	DNA-binding site [nucleotide binding]; DNA binding site
1225522010497	FCD domain; Region: FCD; pfam07729
1225522010498	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1225522010499	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1225522010500	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1225522010501	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1225522010502	active site
1225522010503	intersubunit interface [polypeptide binding]; other site
1225522010504	catalytic residue [active]
1225522010505	galactonate dehydratase; Provisional; Region: PRK14017
1225522010506	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1225522010507	putative active site pocket [active]
1225522010508	putative metal binding site [ion binding]; other site
1225522010509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010510	D-galactonate transporter; Region: 2A0114; TIGR00893
1225522010511	putative substrate translocation pore; other site
1225522010512	chaperone protein TorD; Validated; Region: torD; PRK04976
1225522010513	Haem-binding domain; Region: Haem_bd; pfam14376
1225522010514	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1225522010515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522010516	Walker A/P-loop; other site
1225522010517	ATP binding site [chemical binding]; other site
1225522010518	Q-loop/lid; other site
1225522010519	ABC transporter signature motif; other site
1225522010520	Walker B; other site
1225522010521	D-loop; other site
1225522010522	H-loop/switch region; other site
1225522010523	heme exporter protein CcmB; Region: ccmB; TIGR01190
1225522010524	heme exporter protein CcmC; Region: ccmC; TIGR01191
1225522010525	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1225522010526	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
1225522010527	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
1225522010528	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
1225522010529	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1225522010530	catalytic residues [active]
1225522010531	central insert; other site
1225522010532	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
1225522010533	hypothetical protein; Provisional; Region: PRK11616
1225522010534	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1225522010535	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1225522010536	putative dimer interface [polypeptide binding]; other site
1225522010537	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1225522010538	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1225522010539	putative dimer interface [polypeptide binding]; other site
1225522010540	putative transporter; Validated; Region: PRK03818
1225522010541	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1225522010542	TrkA-C domain; Region: TrkA_C; pfam02080
1225522010543	TrkA-C domain; Region: TrkA_C; pfam02080
1225522010544	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1225522010545	Predicted membrane protein [Function unknown]; Region: COG2149
1225522010546	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1225522010547	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
1225522010548	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
1225522010549	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1225522010550	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1225522010551	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522010552	catalytic residue [active]
1225522010553	permease DsdX; Provisional; Region: PRK09921
1225522010554	gluconate transporter; Region: gntP; TIGR00791
1225522010555	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
1225522010556	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522010557	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1225522010558	dimerization interface [polypeptide binding]; other site
1225522010559	substrate binding pocket [chemical binding]; other site
1225522010560	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
1225522010561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010562	putative substrate translocation pore; other site
1225522010563	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1225522010564	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1225522010565	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
1225522010566	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1225522010567	PYR/PP interface [polypeptide binding]; other site
1225522010568	dimer interface [polypeptide binding]; other site
1225522010569	TPP binding site [chemical binding]; other site
1225522010570	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1225522010571	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1225522010572	TPP-binding site [chemical binding]; other site
1225522010573	dimer interface [polypeptide binding]; other site
1225522010574	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1225522010575	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1225522010576	putative valine binding site [chemical binding]; other site
1225522010577	dimer interface [polypeptide binding]; other site
1225522010578	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1225522010579	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1225522010580	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522010581	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522010582	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1225522010583	substrate binding site [chemical binding]; other site
1225522010584	dimer interface [polypeptide binding]; other site
1225522010585	ATP binding site [chemical binding]; other site
1225522010586	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1225522010587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010588	putative substrate translocation pore; other site
1225522010589	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
1225522010590	active site
1225522010591	catalytic residues [active]
1225522010592	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1225522010593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522010594	active site
1225522010595	phosphorylation site [posttranslational modification]
1225522010596	intermolecular recognition site; other site
1225522010597	dimerization interface [polypeptide binding]; other site
1225522010598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522010599	DNA binding residues [nucleotide binding]
1225522010600	dimerization interface [polypeptide binding]; other site
1225522010601	sensory histidine kinase UhpB; Provisional; Region: PRK11644
1225522010602	MASE1; Region: MASE1; pfam05231
1225522010603	Histidine kinase; Region: HisKA_3; pfam07730
1225522010604	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522010605	ATP binding site [chemical binding]; other site
1225522010606	Mg2+ binding site [ion binding]; other site
1225522010607	G-X-G motif; other site
1225522010608	regulatory protein UhpC; Provisional; Region: PRK11663
1225522010609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010610	putative substrate translocation pore; other site
1225522010611	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1225522010612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522010613	putative substrate translocation pore; other site
1225522010614	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
1225522010615	Predicted transcriptional regulator [Transcription]; Region: COG2944
1225522010616	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522010617	non-specific DNA binding site [nucleotide binding]; other site
1225522010618	salt bridge; other site
1225522010619	sequence-specific DNA binding site [nucleotide binding]; other site
1225522010620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
1225522010621	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1225522010622	beta-galactosidase; Region: BGL; TIGR03356
1225522010623	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1225522010624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522010625	Walker A motif; other site
1225522010626	ATP binding site [chemical binding]; other site
1225522010627	Walker B motif; other site
1225522010628	arginine finger; other site
1225522010629	Transcriptional antiterminator [Transcription]; Region: COG3933
1225522010630	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1225522010631	active site
1225522010632	active pocket/dimerization site; other site
1225522010633	phosphorylation site [posttranslational modification]
1225522010634	PRD domain; Region: PRD; pfam00874
1225522010635	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1225522010636	active pocket/dimerization site; other site
1225522010637	active site
1225522010638	phosphorylation site [posttranslational modification]
1225522010639	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1225522010640	active site
1225522010641	phosphorylation site [posttranslational modification]
1225522010642	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1225522010643	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1225522010644	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1225522010645	hypothetical protein; Provisional; Region: PRK09956
1225522010646	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1225522010647	EamA-like transporter family; Region: EamA; pfam00892
1225522010648	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1225522010649	EamA-like transporter family; Region: EamA; pfam00892
1225522010650	magnesium transport protein MgtC; Provisional; Region: PRK15385
1225522010651	MgtC family; Region: MgtC; pfam02308
1225522010652	magnesium-transporting ATPase; Provisional; Region: PRK15122
1225522010653	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1225522010654	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1225522010655	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1225522010656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522010657	motif II; other site
1225522010658	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1225522010659	Isochorismatase family; Region: Isochorismatase; pfam00857
1225522010660	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1225522010661	catalytic triad [active]
1225522010662	dimer interface [polypeptide binding]; other site
1225522010663	conserved cis-peptide bond; other site
1225522010664	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1225522010665	DNA binding site [nucleotide binding]
1225522010666	autotransport protein MisL; Provisional; Region: PRK15313
1225522010667	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
1225522010668	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1225522010669	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1225522010670	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1225522010671	Transposase; Region: HTH_Tnp_1; pfam01527
1225522010672	Virulence protein [General function prediction only]; Region: COG3943
1225522010673	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
1225522010674	Methyltransferase domain; Region: Methyltransf_27; pfam13708
1225522010675	putative alpha-glucosidase; Provisional; Region: PRK10658
1225522010676	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1225522010677	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1225522010678	active site
1225522010679	homotrimer interface [polypeptide binding]; other site
1225522010680	catalytic site [active]
1225522010681	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1225522010682	AsmA family; Region: AsmA; pfam05170
1225522010683	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1225522010684	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1225522010685	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1225522010686	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1225522010687	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1225522010688	generic binding surface II; other site
1225522010689	ssDNA binding site; other site
1225522010690	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1225522010691	ATP binding site [chemical binding]; other site
1225522010692	putative Mg++ binding site [ion binding]; other site
1225522010693	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1225522010694	nucleotide binding region [chemical binding]; other site
1225522010695	ATP-binding site [chemical binding]; other site
1225522010696	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
1225522010697	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1225522010698	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
1225522010699	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1225522010700	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1225522010701	Zn2+ binding site [ion binding]; other site
1225522010702	Mg2+ binding site [ion binding]; other site
1225522010703	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1225522010704	synthetase active site [active]
1225522010705	NTP binding site [chemical binding]; other site
1225522010706	metal binding site [ion binding]; metal-binding site
1225522010707	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1225522010708	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1225522010709	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1225522010710	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1225522010711	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1225522010712	catalytic site [active]
1225522010713	G-X2-G-X-G-K; other site
1225522010714	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
1225522010715	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
1225522010716	nucleotide binding pocket [chemical binding]; other site
1225522010717	K-X-D-G motif; other site
1225522010718	catalytic site [active]
1225522010719	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1225522010720	Predicted membrane protein [Function unknown]; Region: COG2860
1225522010721	UPF0126 domain; Region: UPF0126; pfam03458
1225522010722	UPF0126 domain; Region: UPF0126; pfam03458
1225522010723	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1225522010724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522010725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522010726	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1225522010727	dimerization interface [polypeptide binding]; other site
1225522010728	hypothetical protein; Provisional; Region: PRK11820
1225522010729	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1225522010730	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1225522010731	ribonuclease PH; Reviewed; Region: rph; PRK00173
1225522010732	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1225522010733	hexamer interface [polypeptide binding]; other site
1225522010734	active site
1225522010735	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522010736	active site
1225522010737	division inhibitor protein; Provisional; Region: slmA; PRK09480
1225522010738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522010739	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1225522010740	trimer interface [polypeptide binding]; other site
1225522010741	active site
1225522010742	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1225522010743	Flavoprotein; Region: Flavoprotein; pfam02441
1225522010744	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1225522010745	hypothetical protein; Reviewed; Region: PRK00024
1225522010746	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1225522010747	MPN+ (JAMM) motif; other site
1225522010748	Zinc-binding site [ion binding]; other site
1225522010749	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1225522010750	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1225522010751	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1225522010752	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1225522010753	DNA binding site [nucleotide binding]
1225522010754	catalytic residue [active]
1225522010755	H2TH interface [polypeptide binding]; other site
1225522010756	putative catalytic residues [active]
1225522010757	turnover-facilitating residue; other site
1225522010758	intercalation triad [nucleotide binding]; other site
1225522010759	8OG recognition residue [nucleotide binding]; other site
1225522010760	putative reading head residues; other site
1225522010761	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1225522010762	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1225522010763	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1225522010764	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1225522010765	active site
1225522010766	(T/H)XGH motif; other site
1225522010767	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
1225522010768	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1225522010769	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1225522010770	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
1225522010771	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1225522010772	putative active site [active]
1225522010773	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1225522010774	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1225522010775	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
1225522010776	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1225522010777	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
1225522010778	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1225522010779	putative ADP-binding pocket [chemical binding]; other site
1225522010780	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
1225522010781	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1225522010782	Ligand binding site; other site
1225522010783	metal-binding site
1225522010784	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
1225522010785	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1225522010786	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1225522010787	Ligand binding site; other site
1225522010788	metal-binding site
1225522010789	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
1225522010790	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
1225522010791	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
1225522010792	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
1225522010793	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1225522010794	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1225522010795	O-antigen ligase RfaL; Provisional; Region: PRK15487
1225522010796	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1225522010797	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
1225522010798	putative active site [active]
1225522010799	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1225522010800	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1225522010801	putative active site [active]
1225522010802	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1225522010803	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
1225522010804	NADP binding site [chemical binding]; other site
1225522010805	homopentamer interface [polypeptide binding]; other site
1225522010806	substrate binding site [chemical binding]; other site
1225522010807	active site
1225522010808	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1225522010809	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1225522010810	substrate-cofactor binding pocket; other site
1225522010811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522010812	catalytic residue [active]
1225522010813	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1225522010814	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1225522010815	NAD(P) binding site [chemical binding]; other site
1225522010816	putative glycosyl transferase; Provisional; Region: PRK10073
1225522010817	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1225522010818	active site
1225522010819	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1225522010820	NodB motif; other site
1225522010821	putative active site [active]
1225522010822	putative catalytic site [active]
1225522010823	Zn binding site [ion binding]; other site
1225522010824	AmiB activator; Provisional; Region: PRK11637
1225522010825	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1225522010826	Peptidase family M23; Region: Peptidase_M23; pfam01551
1225522010827	phosphoglyceromutase; Provisional; Region: PRK05434
1225522010828	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
1225522010829	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1225522010830	active site residue [active]
1225522010831	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1225522010832	GSH binding site [chemical binding]; other site
1225522010833	catalytic residues [active]
1225522010834	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1225522010835	SecA binding site; other site
1225522010836	Preprotein binding site; other site
1225522010837	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1225522010838	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1225522010839	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1225522010840	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1225522010841	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1225522010842	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1225522010843	trimer interface [polypeptide binding]; other site
1225522010844	active site
1225522010845	substrate binding site [chemical binding]; other site
1225522010846	CoA binding site [chemical binding]; other site
1225522010847	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1225522010848	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1225522010849	active site pocket [active]
1225522010850	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1225522010851	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522010852	DNA binding site [nucleotide binding]
1225522010853	domain linker motif; other site
1225522010854	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1225522010855	putative dimerization interface [polypeptide binding]; other site
1225522010856	putative ligand binding site [chemical binding]; other site
1225522010857	putative rRNA methylase; Provisional; Region: PRK10358
1225522010858	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1225522010859	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1225522010860	active site
1225522010861	substrate binding site [chemical binding]; other site
1225522010862	FMN binding site [chemical binding]; other site
1225522010863	putative catalytic residues [active]
1225522010864	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
1225522010865	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522010866	DNA-binding site [nucleotide binding]; DNA binding site
1225522010867	FCD domain; Region: FCD; pfam07729
1225522010868	L-lactate permease; Provisional; Region: PRK10420
1225522010869	glycolate transporter; Provisional; Region: PRK09695
1225522010870	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
1225522010871	hypothetical protein; Provisional; Region: PRK11020
1225522010872	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
1225522010873	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
1225522010874	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1225522010875	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1225522010876	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1225522010877	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1225522010878	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1225522010879	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1225522010880	active site
1225522010881	P-loop; other site
1225522010882	phosphorylation site [posttranslational modification]
1225522010883	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522010884	active site
1225522010885	phosphorylation site [posttranslational modification]
1225522010886	putative glutathione S-transferase; Provisional; Region: PRK10357
1225522010887	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1225522010888	putative C-terminal domain interface [polypeptide binding]; other site
1225522010889	putative GSH binding site (G-site) [chemical binding]; other site
1225522010890	putative dimer interface [polypeptide binding]; other site
1225522010891	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1225522010892	dimer interface [polypeptide binding]; other site
1225522010893	N-terminal domain interface [polypeptide binding]; other site
1225522010894	putative substrate binding pocket (H-site) [chemical binding]; other site
1225522010895	selenocysteine synthase; Provisional; Region: PRK04311
1225522010896	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1225522010897	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1225522010898	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1225522010899	catalytic residue [active]
1225522010900	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
1225522010901	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1225522010902	G1 box; other site
1225522010903	putative GEF interaction site [polypeptide binding]; other site
1225522010904	GTP/Mg2+ binding site [chemical binding]; other site
1225522010905	Switch I region; other site
1225522010906	G2 box; other site
1225522010907	G3 box; other site
1225522010908	Switch II region; other site
1225522010909	G4 box; other site
1225522010910	G5 box; other site
1225522010911	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1225522010912	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1225522010913	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
1225522010914	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1225522010915	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1225522010916	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1225522010917	nucleotide binding site [chemical binding]; other site
1225522010918	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1225522010919	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1225522010920	NAD(P) binding site [chemical binding]; other site
1225522010921	catalytic residues [active]
1225522010922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1225522010923	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1225522010924	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1225522010925	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1225522010926	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522010927	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1225522010928	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1225522010929	intersubunit interface [polypeptide binding]; other site
1225522010930	active site
1225522010931	Zn2+ binding site [ion binding]; other site
1225522010932	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
1225522010933	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1225522010934	AP (apurinic/apyrimidinic) site pocket; other site
1225522010935	DNA interaction; other site
1225522010936	Metal-binding active site; metal-binding site
1225522010937	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1225522010938	active site
1225522010939	dimer interface [polypeptide binding]; other site
1225522010940	magnesium binding site [ion binding]; other site
1225522010941	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1225522010942	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1225522010943	putative N- and C-terminal domain interface [polypeptide binding]; other site
1225522010944	putative active site [active]
1225522010945	MgATP binding site [chemical binding]; other site
1225522010946	catalytic site [active]
1225522010947	metal binding site [ion binding]; metal-binding site
1225522010948	putative xylulose binding site [chemical binding]; other site
1225522010949	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1225522010950	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
1225522010951	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
1225522010952	DctM-like transporters; Region: DctM; pfam06808
1225522010953	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
1225522010954	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1225522010955	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
1225522010956	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1225522010957	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1225522010958	Bacterial transcriptional regulator; Region: IclR; pfam01614
1225522010959	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1225522010960	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1225522010961	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522010962	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522010963	homodimer interface [polypeptide binding]; other site
1225522010964	catalytic residue [active]
1225522010965	alpha-amylase; Reviewed; Region: malS; PRK09505
1225522010966	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1225522010967	active site
1225522010968	catalytic site [active]
1225522010969	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
1225522010970	hypothetical protein; Provisional; Region: PRK10356
1225522010971	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1225522010972	putative dimerization interface [polypeptide binding]; other site
1225522010973	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1225522010974	putative ligand binding site [chemical binding]; other site
1225522010975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522010976	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522010977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522010978	xylose isomerase; Provisional; Region: PRK05474
1225522010979	xylose isomerase; Region: xylose_isom_A; TIGR02630
1225522010980	xylulokinase; Provisional; Region: PRK15027
1225522010981	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1225522010982	N- and C-terminal domain interface [polypeptide binding]; other site
1225522010983	active site
1225522010984	MgATP binding site [chemical binding]; other site
1225522010985	catalytic site [active]
1225522010986	metal binding site [ion binding]; metal-binding site
1225522010987	xylulose binding site [chemical binding]; other site
1225522010988	homodimer interface [polypeptide binding]; other site
1225522010989	Predicted membrane protein [Function unknown]; Region: COG4682
1225522010990	yiaA/B two helix domain; Region: YiaAB; cl01759
1225522010991	yiaA/B two helix domain; Region: YiaAB; cl01759
1225522010992	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1225522010993	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1225522010994	YsaB-like lipoprotein; Region: YsaB; pfam13983
1225522010995	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1225522010996	dimer interface [polypeptide binding]; other site
1225522010997	motif 1; other site
1225522010998	active site
1225522010999	motif 2; other site
1225522011000	motif 3; other site
1225522011001	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1225522011002	DALR anticodon binding domain; Region: DALR_1; pfam05746
1225522011003	Integrase core domain; Region: rve; pfam00665
1225522011004	Integrase core domain; Region: rve; pfam00665
1225522011005	Integrase core domain; Region: rve_2; pfam13333
1225522011006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1225522011007	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1225522011008	DNA-binding site [nucleotide binding]; DNA binding site
1225522011009	RNA-binding motif; other site
1225522011010	Predicted transcriptional regulator [Transcription]; Region: COG2944
1225522011011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522011012	salt bridge; other site
1225522011013	non-specific DNA binding site [nucleotide binding]; other site
1225522011014	sequence-specific DNA binding site [nucleotide binding]; other site
1225522011015	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
1225522011016	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1225522011017	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1225522011018	dimerization interface [polypeptide binding]; other site
1225522011019	ligand binding site [chemical binding]; other site
1225522011020	NADP binding site [chemical binding]; other site
1225522011021	catalytic site [active]
1225522011022	putative outer membrane lipoprotein; Provisional; Region: PRK10510
1225522011023	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1225522011024	ligand binding site [chemical binding]; other site
1225522011025	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1225522011026	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1225522011027	molybdopterin cofactor binding site [chemical binding]; other site
1225522011028	substrate binding site [chemical binding]; other site
1225522011029	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1225522011030	molybdopterin cofactor binding site; other site
1225522011031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522011032	Coenzyme A binding pocket [chemical binding]; other site
1225522011033	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
1225522011034	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
1225522011035	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
1225522011036	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
1225522011037	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1225522011038	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1225522011039	long polar fimbrial protein LpfD; Provisional; Region: PRK15206
1225522011040	phosphoethanolamine transferase; Provisional; Region: PRK11560
1225522011041	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1225522011042	Sulfatase; Region: Sulfatase; pfam00884
1225522011043	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1225522011044	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522011045	DNA binding site [nucleotide binding]
1225522011046	domain linker motif; other site
1225522011047	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
1225522011048	putative dimerization interface [polypeptide binding]; other site
1225522011049	putative ligand binding site [chemical binding]; other site
1225522011050	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
1225522011051	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1225522011052	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1225522011053	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1225522011054	peptide binding site [polypeptide binding]; other site
1225522011055	dipeptide transporter; Provisional; Region: PRK10913
1225522011056	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1225522011057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522011058	dimer interface [polypeptide binding]; other site
1225522011059	conserved gate region; other site
1225522011060	putative PBP binding loops; other site
1225522011061	ABC-ATPase subunit interface; other site
1225522011062	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1225522011063	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522011064	Walker A/P-loop; other site
1225522011065	ATP binding site [chemical binding]; other site
1225522011066	Q-loop/lid; other site
1225522011067	ABC transporter signature motif; other site
1225522011068	Walker B; other site
1225522011069	D-loop; other site
1225522011070	H-loop/switch region; other site
1225522011071	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1225522011072	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1225522011073	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1225522011074	Walker A/P-loop; other site
1225522011075	ATP binding site [chemical binding]; other site
1225522011076	Q-loop/lid; other site
1225522011077	ABC transporter signature motif; other site
1225522011078	Walker B; other site
1225522011079	D-loop; other site
1225522011080	H-loop/switch region; other site
1225522011081	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1225522011082	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1225522011083	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1225522011084	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1225522011085	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1225522011086	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
1225522011087	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
1225522011088	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
1225522011089	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
1225522011090	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
1225522011091	cell division protein; Provisional; Region: PRK10037
1225522011092	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
1225522011093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1225522011094	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1225522011095	DXD motif; other site
1225522011096	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1225522011097	PilZ domain; Region: PilZ; pfam07238
1225522011098	cellulose synthase regulator protein; Provisional; Region: PRK11114
1225522011099	endo-1,4-D-glucanase; Provisional; Region: PRK11097
1225522011100	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1225522011101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1225522011102	TPR motif; other site
1225522011103	binding surface
1225522011104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1225522011105	TPR motif; other site
1225522011106	binding surface
1225522011107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1225522011108	binding surface
1225522011109	TPR motif; other site
1225522011110	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1225522011111	putative diguanylate cyclase; Provisional; Region: PRK13561
1225522011112	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522011113	metal binding site [ion binding]; metal-binding site
1225522011114	active site
1225522011115	I-site; other site
1225522011116	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522011117	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1225522011118	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1225522011119	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1225522011120	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1225522011121	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522011122	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1225522011123	substrate binding site [chemical binding]; other site
1225522011124	ATP binding site [chemical binding]; other site
1225522011125	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1225522011126	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1225522011127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522011128	metabolite-proton symporter; Region: 2A0106; TIGR00883
1225522011129	putative substrate translocation pore; other site
1225522011130	inner membrane protein YhjD; Region: TIGR00766
1225522011131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522011132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522011133	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1225522011134	putative effector binding pocket; other site
1225522011135	putative dimerization interface [polypeptide binding]; other site
1225522011136	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1225522011137	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522011138	DNA binding residues [nucleotide binding]
1225522011139	dimerization interface [polypeptide binding]; other site
1225522011140	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
1225522011141	catalytic residue [active]
1225522011142	trehalase; Provisional; Region: treF; PRK13270
1225522011143	Trehalase; Region: Trehalase; pfam01204
1225522011144	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1225522011145	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522011146	DNA-binding site [nucleotide binding]; DNA binding site
1225522011147	UTRA domain; Region: UTRA; pfam07702
1225522011148	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1225522011149	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1225522011150	putative active site [active]
1225522011151	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1225522011152	dimer interface [polypeptide binding]; other site
1225522011153	active site
1225522011154	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
1225522011155	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1225522011156	substrate binding site [chemical binding]; other site
1225522011157	ATP binding site [chemical binding]; other site
1225522011158	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1225522011159	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1225522011160	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1225522011161	active site
1225522011162	homodimer interface [polypeptide binding]; other site
1225522011163	homotetramer interface [polypeptide binding]; other site
1225522011164	glutathione reductase; Validated; Region: PRK06116
1225522011165	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522011166	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522011167	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1225522011168	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1225522011169	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1225522011170	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1225522011171	active site
1225522011172	oligopeptidase A; Provisional; Region: PRK10911
1225522011173	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1225522011174	active site
1225522011175	Zn binding site [ion binding]; other site
1225522011176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522011177	S-adenosylmethionine binding site [chemical binding]; other site
1225522011178	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1225522011179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522011180	putative substrate translocation pore; other site
1225522011181	POT family; Region: PTR2; pfam00854
1225522011182	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1225522011183	Ligand Binding Site [chemical binding]; other site
1225522011184	universal stress protein UspB; Provisional; Region: PRK04960
1225522011185	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1225522011186	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1225522011187	Predicted flavoproteins [General function prediction only]; Region: COG2081
1225522011188	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1225522011189	HlyD family secretion protein; Region: HlyD; pfam00529
1225522011190	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522011191	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522011192	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1225522011193	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1225522011194	nickel responsive regulator; Provisional; Region: PRK02967
1225522011195	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1225522011196	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
1225522011197	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1225522011198	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1225522011199	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1225522011200	major facilitator superfamily transporter; Provisional; Region: PRK05122
1225522011201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522011202	putative substrate translocation pore; other site
1225522011203	hypothetical protein; Provisional; Region: PRK11615
1225522011204	hypothetical protein; Provisional; Region: PRK11212
1225522011205	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1225522011206	CPxP  motif; other site
1225522011207	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
1225522011208	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1225522011209	dimer interface [polypeptide binding]; other site
1225522011210	ligand binding site [chemical binding]; other site
1225522011211	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522011212	dimerization interface [polypeptide binding]; other site
1225522011213	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522011214	dimer interface [polypeptide binding]; other site
1225522011215	putative CheW interface [polypeptide binding]; other site
1225522011216	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
1225522011217	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1225522011218	metal-binding site [ion binding]
1225522011219	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1225522011220	Predicted membrane protein [Function unknown]; Region: COG3714
1225522011221	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
1225522011222	hypothetical protein; Provisional; Region: PRK10910
1225522011223	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1225522011224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522011225	S-adenosylmethionine binding site [chemical binding]; other site
1225522011226	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1225522011227	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1225522011228	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1225522011229	P loop; other site
1225522011230	GTP binding site [chemical binding]; other site
1225522011231	cell division protein FtsE; Provisional; Region: PRK10908
1225522011232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522011233	Walker A/P-loop; other site
1225522011234	ATP binding site [chemical binding]; other site
1225522011235	Q-loop/lid; other site
1225522011236	ABC transporter signature motif; other site
1225522011237	Walker B; other site
1225522011238	D-loop; other site
1225522011239	H-loop/switch region; other site
1225522011240	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
1225522011241	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1225522011242	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1225522011243	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1225522011244	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1225522011245	DNA binding residues [nucleotide binding]
1225522011246	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1225522011247	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1225522011248	dimerization interface [polypeptide binding]; other site
1225522011249	ligand binding site [chemical binding]; other site
1225522011250	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
1225522011251	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1225522011252	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1225522011253	dimerization interface [polypeptide binding]; other site
1225522011254	ligand binding site [chemical binding]; other site
1225522011255	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1225522011256	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1225522011257	TM-ABC transporter signature motif; other site
1225522011258	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1225522011259	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1225522011260	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1225522011261	TM-ABC transporter signature motif; other site
1225522011262	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1225522011263	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1225522011264	Walker A/P-loop; other site
1225522011265	ATP binding site [chemical binding]; other site
1225522011266	Q-loop/lid; other site
1225522011267	ABC transporter signature motif; other site
1225522011268	Walker B; other site
1225522011269	D-loop; other site
1225522011270	H-loop/switch region; other site
1225522011271	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
1225522011272	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1225522011273	Walker A/P-loop; other site
1225522011274	ATP binding site [chemical binding]; other site
1225522011275	Q-loop/lid; other site
1225522011276	ABC transporter signature motif; other site
1225522011277	Walker B; other site
1225522011278	D-loop; other site
1225522011279	H-loop/switch region; other site
1225522011280	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1225522011281	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
1225522011282	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
1225522011283	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1225522011284	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1225522011285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522011286	dimer interface [polypeptide binding]; other site
1225522011287	conserved gate region; other site
1225522011288	putative PBP binding loops; other site
1225522011289	ABC-ATPase subunit interface; other site
1225522011290	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1225522011291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522011292	dimer interface [polypeptide binding]; other site
1225522011293	conserved gate region; other site
1225522011294	ABC-ATPase subunit interface; other site
1225522011295	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1225522011296	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1225522011297	Walker A/P-loop; other site
1225522011298	ATP binding site [chemical binding]; other site
1225522011299	Q-loop/lid; other site
1225522011300	ABC transporter signature motif; other site
1225522011301	Walker B; other site
1225522011302	D-loop; other site
1225522011303	H-loop/switch region; other site
1225522011304	TOBE domain; Region: TOBE_2; pfam08402
1225522011305	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
1225522011306	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1225522011307	putative active site [active]
1225522011308	catalytic site [active]
1225522011309	putative metal binding site [ion binding]; other site
1225522011310	hypothetical protein; Provisional; Region: PRK10350
1225522011311	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
1225522011312	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1225522011313	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1225522011314	active site
1225522011315	substrate binding pocket [chemical binding]; other site
1225522011316	homodimer interaction site [polypeptide binding]; other site
1225522011317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1225522011318	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1225522011319	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1225522011320	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1225522011321	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522011322	Coenzyme A binding pocket [chemical binding]; other site
1225522011323	putative oxidoreductase; Provisional; Region: PRK10206
1225522011324	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1225522011325	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1225522011326	Pirin-related protein [General function prediction only]; Region: COG1741
1225522011327	Pirin; Region: Pirin; pfam02678
1225522011328	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1225522011329	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522011330	DNA binding site [nucleotide binding]
1225522011331	domain linker motif; other site
1225522011332	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1225522011333	putative ligand binding site [chemical binding]; other site
1225522011334	putative dimerization interface [polypeptide binding]; other site
1225522011335	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1225522011336	low affinity gluconate transporter; Provisional; Region: PRK10472
1225522011337	gluconate transporter; Region: gntP; TIGR00791
1225522011338	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1225522011339	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1225522011340	glycogen debranching enzyme; Provisional; Region: PRK03705
1225522011341	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1225522011342	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1225522011343	active site
1225522011344	catalytic site [active]
1225522011345	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1225522011346	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1225522011347	ligand binding site; other site
1225522011348	oligomer interface; other site
1225522011349	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1225522011350	dimer interface [polypeptide binding]; other site
1225522011351	N-terminal domain interface [polypeptide binding]; other site
1225522011352	sulfate 1 binding site; other site
1225522011353	glycogen phosphorylase; Provisional; Region: PRK14986
1225522011354	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1225522011355	homodimer interface [polypeptide binding]; other site
1225522011356	active site pocket [active]
1225522011357	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1225522011358	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1225522011359	Bacterial transcriptional regulator; Region: IclR; pfam01614
1225522011360	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1225522011361	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1225522011362	inhibitor site; inhibition site
1225522011363	active site
1225522011364	dimer interface [polypeptide binding]; other site
1225522011365	catalytic residue [active]
1225522011366	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
1225522011367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522011368	D-galactonate transporter; Region: 2A0114; TIGR00893
1225522011369	putative substrate translocation pore; other site
1225522011370	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1225522011371	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1225522011372	dimer interface [polypeptide binding]; other site
1225522011373	active site
1225522011374	metal binding site [ion binding]; metal-binding site
1225522011375	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
1225522011376	hypothetical protein; Provisional; Region: PRK09781
1225522011377	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1225522011378	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1225522011379	active site residue [active]
1225522011380	intramembrane serine protease GlpG; Provisional; Region: PRK10907
1225522011381	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
1225522011382	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1225522011383	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1225522011384	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1225522011385	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522011386	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
1225522011387	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
1225522011388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522011389	Walker A motif; other site
1225522011390	ATP binding site [chemical binding]; other site
1225522011391	Walker B motif; other site
1225522011392	arginine finger; other site
1225522011393	TROVE domain; Region: TROVE; pfam05731
1225522011394	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1225522011395	hypothetical protein; Reviewed; Region: PRK09588
1225522011396	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
1225522011397	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
1225522011398	putative active site [active]
1225522011399	adenylation catalytic residue [active]
1225522011400	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
1225522011401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
1225522011402	transcriptional regulator MalT; Provisional; Region: PRK04841
1225522011403	AAA ATPase domain; Region: AAA_16; pfam13191
1225522011404	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522011405	DNA binding residues [nucleotide binding]
1225522011406	dimerization interface [polypeptide binding]; other site
1225522011407	maltodextrin phosphorylase; Provisional; Region: PRK14985
1225522011408	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1225522011409	homodimer interface [polypeptide binding]; other site
1225522011410	active site pocket [active]
1225522011411	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1225522011412	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1225522011413	gluconate transporter; Region: gntP; TIGR00791
1225522011414	high-affinity gluconate transporter; Provisional; Region: PRK14984
1225522011415	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
1225522011416	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1225522011417	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1225522011418	DNA utilization protein GntX; Provisional; Region: PRK11595
1225522011419	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1225522011420	active site
1225522011421	carboxylesterase BioH; Provisional; Region: PRK10349
1225522011422	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1225522011423	hypothetical protein; Provisional; Region: PRK09956
1225522011424	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1225522011425	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
1225522011426	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
1225522011427	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1225522011428	G1 box; other site
1225522011429	GTP/Mg2+ binding site [chemical binding]; other site
1225522011430	Switch I region; other site
1225522011431	G2 box; other site
1225522011432	G3 box; other site
1225522011433	Switch II region; other site
1225522011434	G4 box; other site
1225522011435	G5 box; other site
1225522011436	Nucleoside recognition; Region: Gate; pfam07670
1225522011437	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1225522011438	Nucleoside recognition; Region: Gate; pfam07670
1225522011439	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
1225522011440	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1225522011441	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1225522011442	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1225522011443	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1225522011444	RNA binding site [nucleotide binding]; other site
1225522011445	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1225522011446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522011447	active site
1225522011448	phosphorylation site [posttranslational modification]
1225522011449	intermolecular recognition site; other site
1225522011450	dimerization interface [polypeptide binding]; other site
1225522011451	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522011452	DNA binding site [nucleotide binding]
1225522011453	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1225522011454	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522011455	dimerization interface [polypeptide binding]; other site
1225522011456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522011457	dimer interface [polypeptide binding]; other site
1225522011458	phosphorylation site [posttranslational modification]
1225522011459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522011460	ATP binding site [chemical binding]; other site
1225522011461	G-X-G motif; other site
1225522011462	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1225522011463	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1225522011464	active site
1225522011465	substrate-binding site [chemical binding]; other site
1225522011466	metal-binding site [ion binding]
1225522011467	ATP binding site [chemical binding]; other site
1225522011468	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1225522011469	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1225522011470	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1225522011471	dimerization interface [polypeptide binding]; other site
1225522011472	domain crossover interface; other site
1225522011473	redox-dependent activation switch; other site
1225522011474	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522011475	RNA binding surface [nucleotide binding]; other site
1225522011476	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1225522011477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522011478	motif II; other site
1225522011479	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
1225522011480	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1225522011481	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1225522011482	ADP-ribose binding site [chemical binding]; other site
1225522011483	dimer interface [polypeptide binding]; other site
1225522011484	active site
1225522011485	nudix motif; other site
1225522011486	metal binding site [ion binding]; metal-binding site
1225522011487	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1225522011488	Transglycosylase; Region: Transgly; pfam00912
1225522011489	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1225522011490	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1225522011491	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1225522011492	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
1225522011493	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
1225522011494	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1225522011495	shikimate kinase; Reviewed; Region: aroK; PRK00131
1225522011496	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1225522011497	ADP binding site [chemical binding]; other site
1225522011498	magnesium binding site [ion binding]; other site
1225522011499	putative shikimate binding site; other site
1225522011500	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1225522011501	active site
1225522011502	dimer interface [polypeptide binding]; other site
1225522011503	metal binding site [ion binding]; metal-binding site
1225522011504	cell division protein DamX; Validated; Region: PRK10905
1225522011505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
1225522011506	DNA adenine methylase; Provisional; Region: PRK10904
1225522011507	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1225522011508	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1225522011509	substrate binding site [chemical binding]; other site
1225522011510	hexamer interface [polypeptide binding]; other site
1225522011511	metal binding site [ion binding]; metal-binding site
1225522011512	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1225522011513	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522011514	motif II; other site
1225522011515	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1225522011516	active site
1225522011517	dimer interface [polypeptide binding]; other site
1225522011518	KMSKS motif; other site
1225522011519	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
1225522011520	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1225522011521	siroheme synthase; Provisional; Region: cysG; PRK10637
1225522011522	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1225522011523	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1225522011524	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1225522011525	active site
1225522011526	SAM binding site [chemical binding]; other site
1225522011527	homodimer interface [polypeptide binding]; other site
1225522011528	nitrite transporter NirC; Provisional; Region: PRK11562
1225522011529	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1225522011530	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1225522011531	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1225522011532	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1225522011533	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1225522011534	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1225522011535	putative transporter; Provisional; Region: PRK03699
1225522011536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522011537	putative substrate translocation pore; other site
1225522011538	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1225522011539	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1225522011540	substrate binding site [chemical binding]; other site
1225522011541	hypothetical protein; Provisional; Region: PRK10204
1225522011542	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
1225522011543	cell filamentation protein Fic; Provisional; Region: PRK10347
1225522011544	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1225522011545	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1225522011546	glutamine binding [chemical binding]; other site
1225522011547	catalytic triad [active]
1225522011548	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1225522011549	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1225522011550	inhibitor-cofactor binding pocket; inhibition site
1225522011551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522011552	catalytic residue [active]
1225522011553	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
1225522011554	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1225522011555	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1225522011556	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1225522011557	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1225522011558	ligand binding site [chemical binding]; other site
1225522011559	flexible hinge region; other site
1225522011560	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1225522011561	putative switch regulator; other site
1225522011562	non-specific DNA interactions [nucleotide binding]; other site
1225522011563	DNA binding site [nucleotide binding]
1225522011564	sequence specific DNA binding site [nucleotide binding]; other site
1225522011565	putative cAMP binding site [chemical binding]; other site
1225522011566	hypothetical protein; Provisional; Region: PRK10738
1225522011567	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
1225522011568	active site
1225522011569	hypothetical protein; Provisional; Region: PRK04966
1225522011570	putative hydrolase; Provisional; Region: PRK10985
1225522011571	putative monooxygenase; Provisional; Region: PRK11118
1225522011572	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1225522011573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522011574	Walker A/P-loop; other site
1225522011575	ATP binding site [chemical binding]; other site
1225522011576	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522011577	ABC transporter signature motif; other site
1225522011578	Walker B; other site
1225522011579	D-loop; other site
1225522011580	ABC transporter; Region: ABC_tran_2; pfam12848
1225522011581	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522011582	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
1225522011583	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
1225522011584	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1225522011585	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1225522011586	phi X174 lysis protein; Provisional; Region: PRK02793
1225522011587	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
1225522011588	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1225522011589	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1225522011590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1225522011591	YheO-like PAS domain; Region: PAS_6; pfam08348
1225522011592	HTH domain; Region: HTH_22; pfam13309
1225522011593	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1225522011594	sulfur relay protein TusC; Validated; Region: PRK00211
1225522011595	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
1225522011596	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1225522011597	S17 interaction site [polypeptide binding]; other site
1225522011598	S8 interaction site; other site
1225522011599	16S rRNA interaction site [nucleotide binding]; other site
1225522011600	streptomycin interaction site [chemical binding]; other site
1225522011601	23S rRNA interaction site [nucleotide binding]; other site
1225522011602	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1225522011603	30S ribosomal protein S7; Validated; Region: PRK05302
1225522011604	elongation factor G; Reviewed; Region: PRK00007
1225522011605	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1225522011606	G1 box; other site
1225522011607	putative GEF interaction site [polypeptide binding]; other site
1225522011608	GTP/Mg2+ binding site [chemical binding]; other site
1225522011609	Switch I region; other site
1225522011610	G2 box; other site
1225522011611	G3 box; other site
1225522011612	Switch II region; other site
1225522011613	G4 box; other site
1225522011614	G5 box; other site
1225522011615	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1225522011616	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1225522011617	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1225522011618	elongation factor Tu; Reviewed; Region: PRK00049
1225522011619	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1225522011620	G1 box; other site
1225522011621	GEF interaction site [polypeptide binding]; other site
1225522011622	GTP/Mg2+ binding site [chemical binding]; other site
1225522011623	Switch I region; other site
1225522011624	G2 box; other site
1225522011625	G3 box; other site
1225522011626	Switch II region; other site
1225522011627	G4 box; other site
1225522011628	G5 box; other site
1225522011629	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1225522011630	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1225522011631	Antibiotic Binding Site [chemical binding]; other site
1225522011632	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
1225522011633	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1225522011634	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1225522011635	heme binding site [chemical binding]; other site
1225522011636	ferroxidase pore; other site
1225522011637	ferroxidase diiron center [ion binding]; other site
1225522011638	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1225522011639	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1225522011640	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1225522011641	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
1225522011642	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1225522011643	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1225522011644	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1225522011645	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1225522011646	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1225522011647	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1225522011648	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1225522011649	protein-rRNA interface [nucleotide binding]; other site
1225522011650	putative translocon binding site; other site
1225522011651	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1225522011652	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1225522011653	G-X-X-G motif; other site
1225522011654	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1225522011655	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1225522011656	23S rRNA interface [nucleotide binding]; other site
1225522011657	5S rRNA interface [nucleotide binding]; other site
1225522011658	putative antibiotic binding site [chemical binding]; other site
1225522011659	L25 interface [polypeptide binding]; other site
1225522011660	L27 interface [polypeptide binding]; other site
1225522011661	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1225522011662	23S rRNA interface [nucleotide binding]; other site
1225522011663	putative translocon interaction site; other site
1225522011664	signal recognition particle (SRP54) interaction site; other site
1225522011665	L23 interface [polypeptide binding]; other site
1225522011666	trigger factor interaction site; other site
1225522011667	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1225522011668	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1225522011669	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1225522011670	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1225522011671	RNA binding site [nucleotide binding]; other site
1225522011672	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1225522011673	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1225522011674	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1225522011675	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1225522011676	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1225522011677	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1225522011678	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1225522011679	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1225522011680	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1225522011681	23S rRNA interface [nucleotide binding]; other site
1225522011682	5S rRNA interface [nucleotide binding]; other site
1225522011683	L27 interface [polypeptide binding]; other site
1225522011684	L5 interface [polypeptide binding]; other site
1225522011685	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1225522011686	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1225522011687	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1225522011688	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1225522011689	23S rRNA binding site [nucleotide binding]; other site
1225522011690	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1225522011691	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1225522011692	SecY translocase; Region: SecY; pfam00344
1225522011693	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1225522011694	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1225522011695	30S ribosomal protein S11; Validated; Region: PRK05309
1225522011696	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1225522011697	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1225522011698	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522011699	RNA binding surface [nucleotide binding]; other site
1225522011700	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1225522011701	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1225522011702	alphaNTD homodimer interface [polypeptide binding]; other site
1225522011703	alphaNTD - beta interaction site [polypeptide binding]; other site
1225522011704	alphaNTD - beta' interaction site [polypeptide binding]; other site
1225522011705	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1225522011706	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1225522011707	hypothetical protein; Provisional; Region: PRK10203
1225522011708	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1225522011709	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1225522011710	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1225522011711	TrkA-N domain; Region: TrkA_N; pfam02254
1225522011712	TrkA-C domain; Region: TrkA_C; pfam02080
1225522011713	TrkA-N domain; Region: TrkA_N; pfam02254
1225522011714	TrkA-C domain; Region: TrkA_C; pfam02080
1225522011715	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1225522011716	putative RNA binding site [nucleotide binding]; other site
1225522011717	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1225522011718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522011719	S-adenosylmethionine binding site [chemical binding]; other site
1225522011720	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1225522011721	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1225522011722	putative active site [active]
1225522011723	substrate binding site [chemical binding]; other site
1225522011724	putative cosubstrate binding site; other site
1225522011725	catalytic site [active]
1225522011726	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1225522011727	substrate binding site [chemical binding]; other site
1225522011728	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1225522011729	active site
1225522011730	catalytic residues [active]
1225522011731	metal binding site [ion binding]; metal-binding site
1225522011732	hypothetical protein; Validated; Region: PRK03430
1225522011733	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1225522011734	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1225522011735	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1225522011736	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1225522011737	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
1225522011738	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1225522011739	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1225522011740	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1225522011741	shikimate binding site; other site
1225522011742	NAD(P) binding site [chemical binding]; other site
1225522011743	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1225522011744	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1225522011745	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1225522011746	trimer interface [polypeptide binding]; other site
1225522011747	putative metal binding site [ion binding]; other site
1225522011748	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1225522011749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522011750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1225522011751	Coenzyme A binding pocket [chemical binding]; other site
1225522011752	homoserine O-succinyltransferase; Provisional; Region: PRK05368
1225522011753	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1225522011754	proposed active site lysine [active]
1225522011755	conserved cys residue [active]
1225522011756	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1225522011757	malate synthase A; Region: malate_syn_A; TIGR01344
1225522011758	active site
1225522011759	isocitrate lyase; Provisional; Region: PRK15063
1225522011760	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1225522011761	tetramer interface [polypeptide binding]; other site
1225522011762	active site
1225522011763	Mg2+/Mn2+ binding site [ion binding]; other site
1225522011764	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1225522011765	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
1225522011766	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1225522011767	transcriptional repressor IclR; Provisional; Region: PRK11569
1225522011768	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1225522011769	Bacterial transcriptional regulator; Region: IclR; pfam01614
1225522011770	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1225522011771	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1225522011772	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1225522011773	substrate binding pocket [chemical binding]; other site
1225522011774	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1225522011775	B12 binding site [chemical binding]; other site
1225522011776	cobalt ligand [ion binding]; other site
1225522011777	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1225522011778	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1225522011779	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1225522011780	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1225522011781	active site pocket [active]
1225522011782	oxyanion hole [active]
1225522011783	catalytic triad [active]
1225522011784	active site nucleophile [active]
1225522011785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
1225522011786	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
1225522011787	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1225522011788	RNA binding surface [nucleotide binding]; other site
1225522011789	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1225522011790	probable active site [active]
1225522011791	hypothetical protein; Provisional; Region: PRK10515
1225522011792	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1225522011793	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1225522011794	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522011795	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1225522011796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522011797	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1225522011798	phosphate binding site [ion binding]; other site
1225522011799	Mor transcription activator family; Region: Mor; pfam08765
1225522011800	aspartate kinase III; Validated; Region: PRK09084
1225522011801	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1225522011802	nucleotide binding site [chemical binding]; other site
1225522011803	substrate binding site [chemical binding]; other site
1225522011804	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1225522011805	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
1225522011806	dimer interface [polypeptide binding]; other site
1225522011807	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1225522011808	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1225522011809	active site
1225522011810	dimer interface [polypeptide binding]; other site
1225522011811	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1225522011812	dimer interface [polypeptide binding]; other site
1225522011813	active site
1225522011814	Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106
1225522011815	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
1225522011816	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
1225522011817	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
1225522011818	Predicted membrane protein [Function unknown]; Region: COG3223
1225522011819	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1225522011820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522011821	dimer interface [polypeptide binding]; other site
1225522011822	conserved gate region; other site
1225522011823	putative PBP binding loops; other site
1225522011824	ABC-ATPase subunit interface; other site
1225522011825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1225522011826	dimer interface [polypeptide binding]; other site
1225522011827	conserved gate region; other site
1225522011828	putative PBP binding loops; other site
1225522011829	ABC-ATPase subunit interface; other site
1225522011830	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
1225522011831	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1225522011832	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1225522011833	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1225522011834	Walker A/P-loop; other site
1225522011835	ATP binding site [chemical binding]; other site
1225522011836	Q-loop/lid; other site
1225522011837	ABC transporter signature motif; other site
1225522011838	Walker B; other site
1225522011839	D-loop; other site
1225522011840	H-loop/switch region; other site
1225522011841	TOBE domain; Region: TOBE_2; pfam08402
1225522011842	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1225522011843	trimer interface; other site
1225522011844	sugar binding site [chemical binding]; other site
1225522011845	maltose regulon periplasmic protein; Provisional; Region: PRK10564
1225522011846	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
1225522011847	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1225522011848	UbiA prenyltransferase family; Region: UbiA; pfam01040
1225522011849	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1225522011850	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1225522011851	putative acyl-acceptor binding pocket; other site
1225522011852	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1225522011853	LexA repressor; Validated; Region: PRK00215
1225522011854	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1225522011855	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1225522011856	Catalytic site [active]
1225522011857	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1225522011858	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1225522011859	hypothetical protein; Provisional; Region: PRK10428
1225522011860	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1225522011861	metal binding site 2 [ion binding]; metal-binding site
1225522011862	putative DNA binding helix; other site
1225522011863	metal binding site 1 [ion binding]; metal-binding site
1225522011864	dimer interface [polypeptide binding]; other site
1225522011865	structural Zn2+ binding site [ion binding]; other site
1225522011866	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
1225522011867	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1225522011868	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1225522011869	FMN binding site [chemical binding]; other site
1225522011870	active site
1225522011871	catalytic residues [active]
1225522011872	substrate binding site [chemical binding]; other site
1225522011873	phage shock protein G; Reviewed; Region: pspG; PRK09459
1225522011874	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1225522011875	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1225522011876	NADP binding site [chemical binding]; other site
1225522011877	dimer interface [polypeptide binding]; other site
1225522011878	replicative DNA helicase; Provisional; Region: PRK08006
1225522011879	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1225522011880	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1225522011881	Walker A motif; other site
1225522011882	ATP binding site [chemical binding]; other site
1225522011883	Walker B motif; other site
1225522011884	DNA binding loops [nucleotide binding]
1225522011885	alanine racemase; Reviewed; Region: alr; PRK00053
1225522011886	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1225522011887	active site
1225522011888	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1225522011889	substrate binding site [chemical binding]; other site
1225522011890	catalytic residues [active]
1225522011891	dimer interface [polypeptide binding]; other site
1225522011892	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1225522011893	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1225522011894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522011895	homodimer interface [polypeptide binding]; other site
1225522011896	catalytic residue [active]
1225522011897	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
1225522011898	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
1225522011899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1225522011900	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1225522011901	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1225522011902	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1225522011903	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1225522011904	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1225522011905	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1225522011906	dimer interface [polypeptide binding]; other site
1225522011907	ssDNA binding site [nucleotide binding]; other site
1225522011908	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1225522011909	hypothetical protein; Validated; Region: PRK09039
1225522011910	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
1225522011911	Outer membrane efflux protein; Region: OEP; pfam02321
1225522011912	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1225522011913	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1225522011914	HlyD family secretion protein; Region: HlyD_3; pfam13437
1225522011915	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011916	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1225522011917	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011918	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011919	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011920	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1225522011921	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1225522011922	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011923	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1225522011924	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011925	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1225522011926	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1225522011927	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011928	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1225522011929	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1225522011930	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011931	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1225522011932	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1225522011933	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1225522011934	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1225522011935	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1225522011936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1225522011937	Walker A/P-loop; other site
1225522011938	ATP binding site [chemical binding]; other site
1225522011939	Q-loop/lid; other site
1225522011940	ABC transporter signature motif; other site
1225522011941	Walker B; other site
1225522011942	D-loop; other site
1225522011943	H-loop/switch region; other site
1225522011944	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1225522011945	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1225522011946	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1225522011947	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1225522011948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522011949	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
1225522011950	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1225522011951	DNA binding residues [nucleotide binding]
1225522011952	dimer interface [polypeptide binding]; other site
1225522011953	[2Fe-2S] cluster binding site [ion binding]; other site
1225522011954	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1225522011955	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1225522011956	putative C-terminal domain interface [polypeptide binding]; other site
1225522011957	putative GSH binding site (G-site) [chemical binding]; other site
1225522011958	putative dimer interface [polypeptide binding]; other site
1225522011959	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1225522011960	putative N-terminal domain interface [polypeptide binding]; other site
1225522011961	putative dimer interface [polypeptide binding]; other site
1225522011962	putative substrate binding pocket (H-site) [chemical binding]; other site
1225522011963	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1225522011964	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1225522011965	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1225522011966	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1225522011967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1225522011968	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1225522011969	putative dimerization interface [polypeptide binding]; other site
1225522011970	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1225522011971	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1225522011972	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1225522011973	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1225522011974	Na binding site [ion binding]; other site
1225522011975	Predicted membrane protein [Function unknown]; Region: COG3162
1225522011976	acetyl-CoA synthetase; Provisional; Region: PRK00174
1225522011977	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1225522011978	active site
1225522011979	CoA binding site [chemical binding]; other site
1225522011980	acyl-activating enzyme (AAE) consensus motif; other site
1225522011981	AMP binding site [chemical binding]; other site
1225522011982	acetate binding site [chemical binding]; other site
1225522011983	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
1225522011984	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
1225522011985	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
1225522011986	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
1225522011987	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
1225522011988	heme lyase subunit NrfE; Provisional; Region: PRK10369
1225522011989	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
1225522011990	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
1225522011991	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1225522011992	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1225522011993	Sel1-like repeats; Region: SEL1; smart00671
1225522011994	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1225522011995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522011996	Coenzyme A binding pocket [chemical binding]; other site
1225522011997	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1225522011998	dimer interface [polypeptide binding]; other site
1225522011999	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1225522012000	hypothetical protein; Provisional; Region: PRK10220
1225522012001	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1225522012002	PhnA protein; Region: PhnA; pfam03831
1225522012003	proline/glycine betaine transporter; Provisional; Region: PRK10642
1225522012004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522012005	putative substrate translocation pore; other site
1225522012006	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
1225522012007	sensor protein BasS/PmrB; Provisional; Region: PRK10755
1225522012008	HAMP domain; Region: HAMP; pfam00672
1225522012009	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522012010	dimer interface [polypeptide binding]; other site
1225522012011	phosphorylation site [posttranslational modification]
1225522012012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522012013	ATP binding site [chemical binding]; other site
1225522012014	Mg2+ binding site [ion binding]; other site
1225522012015	G-X-G motif; other site
1225522012016	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1225522012017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522012018	active site
1225522012019	phosphorylation site [posttranslational modification]
1225522012020	intermolecular recognition site; other site
1225522012021	dimerization interface [polypeptide binding]; other site
1225522012022	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522012023	DNA binding site [nucleotide binding]
1225522012024	putative metal dependent hydrolase; Provisional; Region: PRK11598
1225522012025	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1225522012026	Sulfatase; Region: Sulfatase; pfam00884
1225522012027	arginine:agmatin antiporter; Provisional; Region: PRK10644
1225522012028	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
1225522012029	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522012030	arginine decarboxylase; Provisional; Region: PRK15029
1225522012031	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1225522012032	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1225522012033	homodimer interface [polypeptide binding]; other site
1225522012034	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1225522012035	catalytic residue [active]
1225522012036	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1225522012037	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
1225522012038	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522012039	alpha-galactosidase; Provisional; Region: PRK15076
1225522012040	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1225522012041	NAD binding site [chemical binding]; other site
1225522012042	sugar binding site [chemical binding]; other site
1225522012043	divalent metal binding site [ion binding]; other site
1225522012044	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1225522012045	dimer interface [polypeptide binding]; other site
1225522012046	fumarate hydratase; Provisional; Region: PRK15389
1225522012047	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1225522012048	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1225522012049	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1225522012050	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1225522012051	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
1225522012052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522012053	active site
1225522012054	phosphorylation site [posttranslational modification]
1225522012055	intermolecular recognition site; other site
1225522012056	dimerization interface [polypeptide binding]; other site
1225522012057	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1225522012058	PAS domain; Region: PAS; smart00091
1225522012059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522012060	ATP binding site [chemical binding]; other site
1225522012061	Mg2+ binding site [ion binding]; other site
1225522012062	G-X-G motif; other site
1225522012063	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1225522012064	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
1225522012065	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1225522012066	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
1225522012067	SdiA-regulated; Region: SdiA-regulated; pfam06977
1225522012068	SdiA-regulated; Region: SdiA-regulated; cd09971
1225522012069	putative active site [active]
1225522012070	AraC family transcriptional regulator; Provisional; Region: PRK15186
1225522012071	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522012072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1225522012073	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522012074	Coenzyme A binding pocket [chemical binding]; other site
1225522012075	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1225522012076	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1225522012077	active site
1225522012078	putative transcriptional regulator; Provisional; Region: PRK11640
1225522012079	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1225522012080	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1225522012081	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1225522012082	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1225522012083	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1225522012084	DsbD alpha interface [polypeptide binding]; other site
1225522012085	catalytic residues [active]
1225522012086	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
1225522012087	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1225522012088	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1225522012089	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1225522012090	Aspartase; Region: Aspartase; cd01357
1225522012091	active sites [active]
1225522012092	tetramer interface [polypeptide binding]; other site
1225522012093	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1225522012094	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1225522012095	oligomerisation interface [polypeptide binding]; other site
1225522012096	mobile loop; other site
1225522012097	roof hairpin; other site
1225522012098	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1225522012099	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1225522012100	ring oligomerisation interface [polypeptide binding]; other site
1225522012101	ATP/Mg binding site [chemical binding]; other site
1225522012102	stacking interactions; other site
1225522012103	hinge regions; other site
1225522012104	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
1225522012105	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
1225522012106	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522012107	FeS/SAM binding site; other site
1225522012108	elongation factor P; Validated; Region: PRK00529
1225522012109	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1225522012110	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1225522012111	RNA binding site [nucleotide binding]; other site
1225522012112	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1225522012113	RNA binding site [nucleotide binding]; other site
1225522012114	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1225522012115	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522012116	DNA binding residues [nucleotide binding]
1225522012117	dimerization interface [polypeptide binding]; other site
1225522012118	multidrug efflux system protein; Provisional; Region: PRK11431
1225522012119	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1225522012120	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1225522012121	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1225522012122	Iron-sulfur protein interface; other site
1225522012123	proximal quinone binding site [chemical binding]; other site
1225522012124	C-subunit interface; other site
1225522012125	distal quinone binding site; other site
1225522012126	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1225522012127	D-subunit interface [polypeptide binding]; other site
1225522012128	Iron-sulfur protein interface; other site
1225522012129	proximal quinone binding site [chemical binding]; other site
1225522012130	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1225522012131	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1225522012132	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
1225522012133	L-aspartate oxidase; Provisional; Region: PRK06175
1225522012134	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1225522012135	poxB regulator PoxA; Provisional; Region: PRK09350
1225522012136	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1225522012137	motif 1; other site
1225522012138	dimer interface [polypeptide binding]; other site
1225522012139	active site
1225522012140	motif 2; other site
1225522012141	motif 3; other site
1225522012142	inner membrane transporter YjeM; Provisional; Region: PRK15238
1225522012143	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
1225522012144	putative mechanosensitive channel protein; Provisional; Region: PRK10929
1225522012145	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1225522012146	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1225522012147	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1225522012148	GTPase RsgA; Reviewed; Region: PRK12288
1225522012149	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1225522012150	RNA binding site [nucleotide binding]; other site
1225522012151	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1225522012152	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1225522012153	GTP/Mg2+ binding site [chemical binding]; other site
1225522012154	G4 box; other site
1225522012155	G5 box; other site
1225522012156	G1 box; other site
1225522012157	Switch I region; other site
1225522012158	G2 box; other site
1225522012159	G3 box; other site
1225522012160	Switch II region; other site
1225522012161	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1225522012162	catalytic site [active]
1225522012163	putative active site [active]
1225522012164	putative substrate binding site [chemical binding]; other site
1225522012165	dimer interface [polypeptide binding]; other site
1225522012166	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1225522012167	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1225522012168	substrate binding pocket [chemical binding]; other site
1225522012169	membrane-bound complex binding site; other site
1225522012170	hinge residues; other site
1225522012171	epoxyqueuosine reductase; Region: TIGR00276
1225522012172	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1225522012173	putative carbohydrate kinase; Provisional; Region: PRK10565
1225522012174	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1225522012175	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1225522012176	putative substrate binding site [chemical binding]; other site
1225522012177	putative ATP binding site [chemical binding]; other site
1225522012178	ADP-binding protein; Provisional; Region: PRK10646
1225522012179	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
1225522012180	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1225522012181	active site
1225522012182	metal binding site [ion binding]; metal-binding site
1225522012183	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1225522012184	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1225522012185	bacterial Hfq-like; Region: Hfq; cd01716
1225522012186	hexamer interface [polypeptide binding]; other site
1225522012187	Sm1 motif; other site
1225522012188	RNA binding site [nucleotide binding]; other site
1225522012189	Sm2 motif; other site
1225522012190	GTPase HflX; Provisional; Region: PRK11058
1225522012191	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1225522012192	HflX GTPase family; Region: HflX; cd01878
1225522012193	G1 box; other site
1225522012194	GTP/Mg2+ binding site [chemical binding]; other site
1225522012195	Switch I region; other site
1225522012196	G2 box; other site
1225522012197	G3 box; other site
1225522012198	Switch II region; other site
1225522012199	G4 box; other site
1225522012200	G5 box; other site
1225522012201	FtsH protease regulator HflK; Provisional; Region: PRK10930
1225522012202	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1225522012203	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1225522012204	FtsH protease regulator HflC; Provisional; Region: PRK11029
1225522012205	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1225522012206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
1225522012207	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1225522012208	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1225522012209	GDP-binding site [chemical binding]; other site
1225522012210	ACT binding site; other site
1225522012211	IMP binding site; other site
1225522012212	Predicted transcriptional regulator [Transcription]; Region: COG1959
1225522012213	transcriptional repressor NsrR; Provisional; Region: PRK11014
1225522012214	exoribonuclease R; Provisional; Region: PRK11642
1225522012215	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1225522012216	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1225522012217	RNB domain; Region: RNB; pfam00773
1225522012218	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1225522012219	RNA binding site [nucleotide binding]; other site
1225522012220	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1225522012221	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1225522012222	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1225522012223	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
1225522012224	Ion channel; Region: Ion_trans_2; pfam07885
1225522012225	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1225522012226	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
1225522012227	Predicted membrane protein [Function unknown]; Region: COG3766
1225522012228	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1225522012229	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1225522012230	Predicted integral membrane protein [Function unknown]; Region: COG5463
1225522012231	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1225522012232	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1225522012233	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
1225522012234	FAD binding site [chemical binding]; other site
1225522012235	substrate binding site [chemical binding]; other site
1225522012236	catalytic residues [active]
1225522012237	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522012238	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
1225522012239	esterase; Provisional; Region: PRK10566
1225522012240	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1225522012241	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1225522012242	transcriptional repressor UlaR; Provisional; Region: PRK13509
1225522012243	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1225522012244	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1225522012245	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1225522012246	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1225522012247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
1225522012248	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
1225522012249	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1225522012250	active site
1225522012251	P-loop; other site
1225522012252	phosphorylation site [posttranslational modification]
1225522012253	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522012254	active site
1225522012255	phosphorylation site [posttranslational modification]
1225522012256	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1225522012257	active site
1225522012258	dimer interface [polypeptide binding]; other site
1225522012259	magnesium binding site [ion binding]; other site
1225522012260	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
1225522012261	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1225522012262	AP (apurinic/apyrimidinic) site pocket; other site
1225522012263	DNA interaction; other site
1225522012264	Metal-binding active site; metal-binding site
1225522012265	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1225522012266	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1225522012267	intersubunit interface [polypeptide binding]; other site
1225522012268	active site
1225522012269	Zn2+ binding site [ion binding]; other site
1225522012270	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1225522012271	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1225522012272	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1225522012273	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1225522012274	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1225522012275	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1225522012276	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1225522012277	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1225522012278	EamA-like transporter family; Region: EamA; pfam00892
1225522012279	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
1225522012280	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1225522012281	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1225522012282	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
1225522012283	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1225522012284	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1225522012285	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1225522012286	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
1225522012287	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1225522012288	Hemerythrin-like domain; Region: Hr-like; cd12108
1225522012289	Fe binding site [ion binding]; other site
1225522012290	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1225522012291	EamA-like transporter family; Region: EamA; pfam00892
1225522012292	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1225522012293	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1225522012294	NADP binding site [chemical binding]; other site
1225522012295	Predicted transcriptional regulators [Transcription]; Region: COG1733
1225522012296	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1225522012297	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1225522012298	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1225522012299	active site
1225522012300	metal binding site [ion binding]; metal-binding site
1225522012301	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1225522012302	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1225522012303	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1225522012304	active site
1225522012305	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
1225522012306	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
1225522012307	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1225522012308	Domain of unknown function DUF21; Region: DUF21; pfam01595
1225522012309	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1225522012310	Transporter associated domain; Region: CorC_HlyC; smart01091
1225522012311	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1225522012312	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1225522012313	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1225522012314	Surface antigen; Region: Bac_surface_Ag; pfam01103
1225522012315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1225522012316	Family of unknown function (DUF490); Region: DUF490; pfam04357
1225522012317	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1225522012318	dimerization interface [polypeptide binding]; other site
1225522012319	putative active site pocket [active]
1225522012320	putative catalytic residue [active]
1225522012321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522012322	D-galactonate transporter; Region: 2A0114; TIGR00893
1225522012323	putative substrate translocation pore; other site
1225522012324	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
1225522012325	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1225522012326	active site
1225522012327	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1225522012328	dimer interface [polypeptide binding]; other site
1225522012329	substrate binding site [chemical binding]; other site
1225522012330	metal binding sites [ion binding]; metal-binding site
1225522012331	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1225522012332	AMP binding site [chemical binding]; other site
1225522012333	metal binding site [ion binding]; metal-binding site
1225522012334	active site
1225522012335	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1225522012336	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1225522012337	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1225522012338	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1225522012339	hypothetical protein; Provisional; Region: PRK05255
1225522012340	peptidase PmbA; Provisional; Region: PRK11040
1225522012341	cytochrome b562; Provisional; Region: PRK15058
1225522012342	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1225522012343	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
1225522012344	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
1225522012345	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
1225522012346	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
1225522012347	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
1225522012348	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1225522012349	active site
1225522012350	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1225522012351	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1225522012352	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1225522012353	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1225522012354	HTH domain; Region: HTH_11; pfam08279
1225522012355	Mga helix-turn-helix domain; Region: Mga; pfam05043
1225522012356	PRD domain; Region: PRD; pfam00874
1225522012357	PRD domain; Region: PRD; pfam00874
1225522012358	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1225522012359	active site
1225522012360	P-loop; other site
1225522012361	phosphorylation site [posttranslational modification]
1225522012362	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1225522012363	active site
1225522012364	phosphorylation site [posttranslational modification]
1225522012365	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
1225522012366	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1225522012367	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1225522012368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1225522012369	FeS/SAM binding site; other site
1225522012370	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1225522012371	ATP cone domain; Region: ATP-cone; pfam03477
1225522012372	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1225522012373	effector binding site; other site
1225522012374	active site
1225522012375	Zn binding site [ion binding]; other site
1225522012376	glycine loop; other site
1225522012377	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
1225522012378	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1225522012379	Ca binding site [ion binding]; other site
1225522012380	active site
1225522012381	catalytic site [active]
1225522012382	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
1225522012383	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1225522012384	active site turn [active]
1225522012385	phosphorylation site [posttranslational modification]
1225522012386	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1225522012387	trehalose repressor; Provisional; Region: treR; PRK09492
1225522012388	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522012389	DNA binding site [nucleotide binding]
1225522012390	domain linker motif; other site
1225522012391	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1225522012392	dimerization interface [polypeptide binding]; other site
1225522012393	ligand binding site [chemical binding]; other site
1225522012394	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
1225522012395	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1225522012396	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1225522012397	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1225522012398	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1225522012399	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1225522012400	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1225522012401	Transposase; Region: HTH_Tnp_1; cl17663
1225522012402	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1225522012403	homotrimer interaction site [polypeptide binding]; other site
1225522012404	putative active site [active]
1225522012405	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
1225522012406	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
1225522012407	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
1225522012408	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
1225522012409	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1225522012410	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1225522012411	Arginine repressor [Transcription]; Region: ArgR; COG1438
1225522012412	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1225522012413	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1225522012414	Predicted membrane protein [Function unknown]; Region: COG1288
1225522012415	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1225522012416	ornithine carbamoyltransferase; Validated; Region: PRK02102
1225522012417	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1225522012418	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1225522012419	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
1225522012420	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1225522012421	putative substrate binding site [chemical binding]; other site
1225522012422	nucleotide binding site [chemical binding]; other site
1225522012423	nucleotide binding site [chemical binding]; other site
1225522012424	homodimer interface [polypeptide binding]; other site
1225522012425	arginine deiminase; Provisional; Region: PRK01388
1225522012426	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1225522012427	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
1225522012428	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1225522012429	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1225522012430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
1225522012431	RNase E inhibitor protein; Provisional; Region: PRK11191
1225522012432	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1225522012433	active site
1225522012434	dinuclear metal binding site [ion binding]; other site
1225522012435	dimerization interface [polypeptide binding]; other site
1225522012436	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
1225522012437	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1225522012438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522012439	Coenzyme A binding pocket [chemical binding]; other site
1225522012440	Predicted membrane protein [Function unknown]; Region: COG4269
1225522012441	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1225522012442	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1225522012443	HIGH motif; other site
1225522012444	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1225522012445	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1225522012446	active site
1225522012447	KMSKS motif; other site
1225522012448	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1225522012449	tRNA binding surface [nucleotide binding]; other site
1225522012450	anticodon binding site; other site
1225522012451	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1225522012452	DNA polymerase III subunit chi; Validated; Region: PRK05728
1225522012453	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1225522012454	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1225522012455	interface (dimer of trimers) [polypeptide binding]; other site
1225522012456	Substrate-binding/catalytic site; other site
1225522012457	Zn-binding sites [ion binding]; other site
1225522012458	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
1225522012459	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1225522012460	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
1225522012461	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1225522012462	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1225522012463	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1225522012464	DNA binding site [nucleotide binding]
1225522012465	domain linker motif; other site
1225522012466	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1225522012467	putative dimerization interface [polypeptide binding]; other site
1225522012468	putative ligand binding site [chemical binding]; other site
1225522012469	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1225522012470	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1225522012471	putative NAD(P) binding site [chemical binding]; other site
1225522012472	catalytic Zn binding site [ion binding]; other site
1225522012473	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1225522012474	ATP-binding site [chemical binding]; other site
1225522012475	Gluconate-6-phosphate binding site [chemical binding]; other site
1225522012476	Shikimate kinase; Region: SKI; pfam01202
1225522012477	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1225522012478	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1225522012479	putative NAD(P) binding site [chemical binding]; other site
1225522012480	putative substrate binding site [chemical binding]; other site
1225522012481	catalytic Zn binding site [ion binding]; other site
1225522012482	structural Zn binding site [ion binding]; other site
1225522012483	dimer interface [polypeptide binding]; other site
1225522012484	Winged helix-turn helix; Region: HTH_29; pfam13551
1225522012485	Homeodomain-like domain; Region: HTH_23; pfam13384
1225522012486	Homeodomain-like domain; Region: HTH_32; pfam13565
1225522012487	Methyltransferase domain; Region: Methyltransf_27; pfam13708
1225522012488	Predicted transcriptional regulator [Transcription]; Region: COG3905
1225522012489	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
1225522012490	CcdB protein; Region: CcdB; pfam01845
1225522012491	Integrase core domain; Region: rve; pfam00665
1225522012492	Integrase core domain; Region: rve_2; pfam13333
1225522012493	HTH-like domain; Region: HTH_21; pfam13276
1225522012494	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1225522012495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522012496	FaeA-like protein; Region: FaeA; pfam04703
1225522012497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522012498	DNA binding residues [nucleotide binding]
1225522012499	dimerization interface [polypeptide binding]; other site
1225522012500	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1225522012501	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1225522012502	catalytic residues [active]
1225522012503	hinge region; other site
1225522012504	alpha helical domain; other site
1225522012505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
1225522012506	SdiA-regulated; Region: SdiA-regulated; cd09971
1225522012507	putative active site [active]
1225522012508	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1225522012509	DNA-binding interface [nucleotide binding]; DNA binding site
1225522012510	hypothetical protein; Provisional; Region: PRK12378
1225522012511	hypothetical protein; Provisional; Region: PRK13687
1225522012512	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
1225522012513	Uncharacterized conserved protein [Function unknown]; Region: COG3439
1225522012514	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1225522012515	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
1225522012516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1225522012517	DNA-binding site [nucleotide binding]; DNA binding site
1225522012518	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1225522012519	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1225522012520	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1225522012521	active site
1225522012522	HIGH motif; other site
1225522012523	dimer interface [polypeptide binding]; other site
1225522012524	KMSKS motif; other site
1225522012525	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
1225522012526	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1225522012527	aspartate racemase; Region: asp_race; TIGR00035
1225522012528	isoaspartyl dipeptidase; Provisional; Region: PRK10657
1225522012529	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1225522012530	active site
1225522012531	hypothetical protein; Provisional; Region: PRK10519
1225522012532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1225522012533	Nucleoside recognition; Region: Gate; pfam07670
1225522012534	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
1225522012535	Predicted membrane protein [Function unknown]; Region: COG2733
1225522012536	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
1225522012537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1225522012538	putative substrate translocation pore; other site
1225522012539	putative transposase; Provisional; Region: PRK09857
1225522012540	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1225522012541	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1225522012542	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1225522012543	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1225522012544	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1225522012545	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1225522012546	Nuclease-related domain; Region: NERD; pfam08378
1225522012547	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
1225522012548	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1225522012549	ATP binding site [chemical binding]; other site
1225522012550	putative Mg++ binding site [ion binding]; other site
1225522012551	Family description; Region: UvrD_C_2; pfam13538
1225522012552	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
1225522012553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
1225522012554	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
1225522012555	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1225522012556	P-loop, Walker A motif; other site
1225522012557	Base recognition motif; other site
1225522012558	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1225522012559	Uncharacterized small protein [Function unknown]; Region: COG2879
1225522012560	carbon starvation protein A; Provisional; Region: PRK15015
1225522012561	Carbon starvation protein CstA; Region: CstA; pfam02554
1225522012562	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1225522012563	methyl-accepting protein IV; Provisional; Region: PRK09793
1225522012564	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1225522012565	dimer interface [polypeptide binding]; other site
1225522012566	ligand binding site [chemical binding]; other site
1225522012567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1225522012568	dimerization interface [polypeptide binding]; other site
1225522012569	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1225522012570	dimer interface [polypeptide binding]; other site
1225522012571	putative CheW interface [polypeptide binding]; other site
1225522012572	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1225522012573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522012574	Walker A motif; other site
1225522012575	ATP binding site [chemical binding]; other site
1225522012576	Walker B motif; other site
1225522012577	arginine finger; other site
1225522012578	Transcriptional antiterminator [Transcription]; Region: COG3933
1225522012579	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1225522012580	active pocket/dimerization site; other site
1225522012581	active site
1225522012582	phosphorylation site [posttranslational modification]
1225522012583	PRD domain; Region: PRD; pfam00874
1225522012584	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1225522012585	active pocket/dimerization site; other site
1225522012586	active site
1225522012587	phosphorylation site [posttranslational modification]
1225522012588	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1225522012589	active site
1225522012590	phosphorylation site [posttranslational modification]
1225522012591	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1225522012592	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1225522012593	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1225522012594	dimer interface [polypeptide binding]; other site
1225522012595	active site
1225522012596	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1225522012597	dimer interface [polypeptide binding]; other site
1225522012598	active site
1225522012599	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1225522012600	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1225522012601	putative active site [active]
1225522012602	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1225522012603	phosphoglycerol transferase I; Provisional; Region: PRK03776
1225522012604	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1225522012605	hypothetical protein; Provisional; Region: PRK11667
1225522012606	DNA replication protein DnaC; Validated; Region: PRK07952
1225522012607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1225522012608	Walker A motif; other site
1225522012609	ATP binding site [chemical binding]; other site
1225522012610	Walker B motif; other site
1225522012611	primosomal protein DnaI; Provisional; Region: PRK02854
1225522012612	hypothetical protein; Provisional; Region: PRK09917
1225522012613	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1225522012614	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1225522012615	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1225522012616	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522012617	DNA binding residues [nucleotide binding]
1225522012618	dimerization interface [polypeptide binding]; other site
1225522012619	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
1225522012620	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1225522012621	DNA binding residues [nucleotide binding]
1225522012622	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1225522012623	putative deacylase active site [active]
1225522012624	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
1225522012625	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1225522012626	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1225522012627	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1225522012628	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1225522012629	metal binding site [ion binding]; metal-binding site
1225522012630	active site
1225522012631	I-site; other site
1225522012632	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
1225522012633	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1225522012634	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1225522012635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1225522012636	S-adenosylmethionine binding site [chemical binding]; other site
1225522012637	DNA polymerase III subunit psi; Validated; Region: PRK06856
1225522012638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1225522012639	Coenzyme A binding pocket [chemical binding]; other site
1225522012640	dUMP phosphatase; Provisional; Region: PRK09449
1225522012641	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522012642	motif II; other site
1225522012643	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1225522012644	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1225522012645	G1 box; other site
1225522012646	putative GEF interaction site [polypeptide binding]; other site
1225522012647	GTP/Mg2+ binding site [chemical binding]; other site
1225522012648	Switch I region; other site
1225522012649	G2 box; other site
1225522012650	G3 box; other site
1225522012651	Switch II region; other site
1225522012652	G4 box; other site
1225522012653	G5 box; other site
1225522012654	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1225522012655	periplasmic protein; Provisional; Region: PRK10568
1225522012656	BON domain; Region: BON; pfam04972
1225522012657	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1225522012658	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1225522012659	active site
1225522012660	nucleophile elbow; other site
1225522012661	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1225522012662	active site
1225522012663	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1225522012664	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1225522012665	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
1225522012666	hypothetical protein; Provisional; Region: PRK10977
1225522012667	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1225522012668	intersubunit interface [polypeptide binding]; other site
1225522012669	active site
1225522012670	catalytic residue [active]
1225522012671	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1225522012672	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1225522012673	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1225522012674	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1225522012675	phosphopentomutase; Provisional; Region: PRK05362
1225522012676	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1225522012677	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1225522012678	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1225522012679	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
1225522012680	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1225522012681	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
1225522012682	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1225522012683	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1225522012684	hypothetical protein; Provisional; Region: PRK11246
1225522012685	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
1225522012686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1225522012687	motif II; other site
1225522012688	DNA repair protein RadA; Region: sms; TIGR00416
1225522012689	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1225522012690	Walker A motif/ATP binding site; other site
1225522012691	ATP binding site [chemical binding]; other site
1225522012692	Walker B motif; other site
1225522012693	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1225522012694	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1225522012695	non-specific DNA binding site [nucleotide binding]; other site
1225522012696	salt bridge; other site
1225522012697	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
1225522012698	sequence-specific DNA binding site [nucleotide binding]; other site
1225522012699	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
1225522012700	active site
1225522012701	(T/H)XGH motif; other site
1225522012702	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1225522012703	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1225522012704	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522012705	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522012706	ABC transporter; Region: ABC_tran_2; pfam12848
1225522012707	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1225522012708	lytic murein transglycosylase; Provisional; Region: PRK11619
1225522012709	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1225522012710	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1225522012711	catalytic residue [active]
1225522012712	Trp operon repressor; Provisional; Region: PRK01381
1225522012713	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
1225522012714	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1225522012715	catalytic core [active]
1225522012716	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
1225522012717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1225522012718	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1225522012719	hypothetical protein; Provisional; Region: PRK10756
1225522012720	CreA protein; Region: CreA; pfam05981
1225522012721	DNA-binding response regulator CreB; Provisional; Region: PRK11083
1225522012722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522012723	active site
1225522012724	phosphorylation site [posttranslational modification]
1225522012725	intermolecular recognition site; other site
1225522012726	dimerization interface [polypeptide binding]; other site
1225522012727	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522012728	DNA binding site [nucleotide binding]
1225522012729	sensory histidine kinase CreC; Provisional; Region: PRK11100
1225522012730	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1225522012731	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1225522012732	dimer interface [polypeptide binding]; other site
1225522012733	phosphorylation site [posttranslational modification]
1225522012734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1225522012735	ATP binding site [chemical binding]; other site
1225522012736	Mg2+ binding site [ion binding]; other site
1225522012737	G-X-G motif; other site
1225522012738	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
1225522012739	putative fimbrial protein SthD; Provisional; Region: PRK15293
1225522012740	putative fimbrial protein SthA; Provisional; Region: PRK15296
1225522012741	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1225522012742	Helix-turn-helix domain; Region: HTH_36; pfam13730
1225522012743	two-component response regulator; Provisional; Region: PRK11173
1225522012744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1225522012745	active site
1225522012746	phosphorylation site [posttranslational modification]
1225522012747	intermolecular recognition site; other site
1225522012748	dimerization interface [polypeptide binding]; other site
1225522012749	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1225522012750	DNA binding site [nucleotide binding]
1225522012751	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1225522012752	putative RNA methyltransferase; Provisional; Region: PRK10433