-- dump date 20140620_051802 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1124936000001 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1124936000002 homotrimer interaction site [polypeptide binding]; other site 1124936000003 zinc binding site [ion binding]; other site 1124936000004 CDP-binding sites; other site 1124936000005 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1124936000006 substrate binding site; other site 1124936000007 dimer interface; other site 1124936000008 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1124936000009 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1124936000010 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1124936000011 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1124936000012 ligand-binding site [chemical binding]; other site 1124936000013 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1124936000014 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1124936000015 CysD dimerization site [polypeptide binding]; other site 1124936000016 G1 box; other site 1124936000017 putative GEF interaction site [polypeptide binding]; other site 1124936000018 GTP/Mg2+ binding site [chemical binding]; other site 1124936000019 Switch I region; other site 1124936000020 G2 box; other site 1124936000021 G3 box; other site 1124936000022 Switch II region; other site 1124936000023 G4 box; other site 1124936000024 G5 box; other site 1124936000025 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1124936000026 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1124936000027 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1124936000028 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1124936000029 Active Sites [active] 1124936000030 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1124936000031 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1124936000032 metal binding site [ion binding]; metal-binding site 1124936000033 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1124936000034 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1124936000035 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1124936000036 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1124936000037 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1124936000038 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1124936000039 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1124936000040 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1124936000041 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1124936000042 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1124936000043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1124936000044 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 1124936000045 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1124936000046 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1124936000047 Active Sites [active] 1124936000048 sulfite reductase subunit beta; Provisional; Region: PRK13504 1124936000049 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124936000050 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124936000051 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1124936000052 Flavodoxin; Region: Flavodoxin_1; pfam00258 1124936000053 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1124936000054 FAD binding pocket [chemical binding]; other site 1124936000055 FAD binding motif [chemical binding]; other site 1124936000056 catalytic residues [active] 1124936000057 NAD binding pocket [chemical binding]; other site 1124936000058 phosphate binding motif [ion binding]; other site 1124936000059 beta-alpha-beta structure motif; other site 1124936000060 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1124936000061 active site 1124936000062 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1124936000063 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1124936000064 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1124936000065 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1124936000066 enolase; Provisional; Region: eno; PRK00077 1124936000067 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1124936000068 dimer interface [polypeptide binding]; other site 1124936000069 metal binding site [ion binding]; metal-binding site 1124936000070 substrate binding pocket [chemical binding]; other site 1124936000071 CTP synthetase; Validated; Region: pyrG; PRK05380 1124936000072 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1124936000073 Catalytic site [active] 1124936000074 active site 1124936000075 UTP binding site [chemical binding]; other site 1124936000076 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1124936000077 active site 1124936000078 putative oxyanion hole; other site 1124936000079 catalytic triad [active] 1124936000080 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1124936000081 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1124936000082 homodimer interface [polypeptide binding]; other site 1124936000083 metal binding site [ion binding]; metal-binding site 1124936000084 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1124936000085 homodimer interface [polypeptide binding]; other site 1124936000086 active site 1124936000087 putative chemical substrate binding site [chemical binding]; other site 1124936000088 metal binding site [ion binding]; metal-binding site 1124936000089 fimbrial protein SteA; Provisional; Region: PRK15261 1124936000090 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 1124936000091 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936000092 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936000093 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936000094 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 1124936000095 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936000096 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936000097 putative fimbrial protein SteD; Provisional; Region: PRK15275 1124936000098 putative fimbrial subunit SteE; Provisional; Region: PRK15276 1124936000099 fimbrial protein SteF; Provisional; Region: PRK15260 1124936000100 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1124936000101 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1124936000102 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1124936000103 HD domain; Region: HD_4; pfam13328 1124936000104 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1124936000105 synthetase active site [active] 1124936000106 NTP binding site [chemical binding]; other site 1124936000107 metal binding site [ion binding]; metal-binding site 1124936000108 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1124936000109 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1124936000110 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1124936000111 TRAM domain; Region: TRAM; pfam01938 1124936000112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936000113 S-adenosylmethionine binding site [chemical binding]; other site 1124936000114 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1124936000115 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1124936000116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936000117 dimerization interface [polypeptide binding]; other site 1124936000118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936000119 dimer interface [polypeptide binding]; other site 1124936000120 phosphorylation site [posttranslational modification] 1124936000121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936000122 ATP binding site [chemical binding]; other site 1124936000123 Mg2+ binding site [ion binding]; other site 1124936000124 G-X-G motif; other site 1124936000125 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1124936000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936000127 active site 1124936000128 phosphorylation site [posttranslational modification] 1124936000129 intermolecular recognition site; other site 1124936000130 dimerization interface [polypeptide binding]; other site 1124936000131 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124936000132 putative binding surface; other site 1124936000133 active site 1124936000134 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1124936000135 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1124936000136 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1124936000137 active site 1124936000138 tetramer interface [polypeptide binding]; other site 1124936000139 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1124936000140 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1124936000141 active site 1124936000142 tetramer interface [polypeptide binding]; other site 1124936000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000144 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936000145 putative substrate translocation pore; other site 1124936000146 flavodoxin; Provisional; Region: PRK08105 1124936000147 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1124936000148 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1124936000149 probable active site [active] 1124936000150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1124936000151 SecY interacting protein Syd; Provisional; Region: PRK04968 1124936000152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1124936000153 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1124936000154 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1124936000155 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1124936000156 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1124936000157 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124936000158 serine transporter; Region: stp; TIGR00814 1124936000159 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1124936000160 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124936000161 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124936000162 flap endonuclease-like protein; Provisional; Region: PRK09482 1124936000163 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1124936000164 active site 1124936000165 metal binding site 1 [ion binding]; metal-binding site 1124936000166 putative 5' ssDNA interaction site; other site 1124936000167 metal binding site 3; metal-binding site 1124936000168 metal binding site 2 [ion binding]; metal-binding site 1124936000169 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1124936000170 putative DNA binding site [nucleotide binding]; other site 1124936000171 putative metal binding site [ion binding]; other site 1124936000172 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1124936000173 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1124936000174 dimer interface [polypeptide binding]; other site 1124936000175 active site 1124936000176 metal binding site [ion binding]; metal-binding site 1124936000177 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1124936000178 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1124936000179 intersubunit interface [polypeptide binding]; other site 1124936000180 active site 1124936000181 Zn2+ binding site [ion binding]; other site 1124936000182 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1124936000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000184 putative substrate translocation pore; other site 1124936000185 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1124936000186 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1124936000187 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1124936000188 trimer interface [polypeptide binding]; other site 1124936000189 substrate binding site [chemical binding]; other site 1124936000190 Mn binding site [ion binding]; other site 1124936000191 L-fuculokinase; Provisional; Region: PRK10331 1124936000192 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1124936000193 nucleotide binding site [chemical binding]; other site 1124936000194 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1124936000195 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1124936000196 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124936000197 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936000198 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1124936000199 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1124936000200 hypothetical protein; Provisional; Region: PRK10873 1124936000201 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124936000202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936000203 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124936000204 dimerization interface [polypeptide binding]; other site 1124936000205 substrate binding pocket [chemical binding]; other site 1124936000206 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124936000207 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1124936000208 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1124936000209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936000210 catalytic residue [active] 1124936000211 CsdA-binding activator; Provisional; Region: PRK15019 1124936000212 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1124936000213 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1124936000214 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1124936000215 putative ATP binding site [chemical binding]; other site 1124936000216 putative substrate interface [chemical binding]; other site 1124936000217 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1124936000218 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1124936000219 MltA specific insert domain; Region: MltA; pfam03562 1124936000220 3D domain; Region: 3D; pfam06725 1124936000221 AMIN domain; Region: AMIN; pfam11741 1124936000222 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1124936000223 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1124936000224 active site 1124936000225 metal binding site [ion binding]; metal-binding site 1124936000226 N-acetylglutamate synthase; Validated; Region: PRK05279 1124936000227 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1124936000228 putative feedback inhibition sensing region; other site 1124936000229 putative nucleotide binding site [chemical binding]; other site 1124936000230 putative substrate binding site [chemical binding]; other site 1124936000231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936000232 Coenzyme A binding pocket [chemical binding]; other site 1124936000233 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1124936000234 AAA domain; Region: AAA_30; pfam13604 1124936000235 Family description; Region: UvrD_C_2; pfam13538 1124936000236 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1124936000237 protease3; Provisional; Region: PRK15101 1124936000238 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1124936000239 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124936000240 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124936000241 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1124936000242 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1124936000243 hypothetical protein; Provisional; Region: PRK10332 1124936000244 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1124936000245 hypothetical protein; Provisional; Region: PRK11521 1124936000246 hypothetical protein; Provisional; Region: PRK10557 1124936000247 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1124936000248 hypothetical protein; Provisional; Region: PRK10506 1124936000249 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1124936000250 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1124936000251 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1124936000252 dimerization interface [polypeptide binding]; other site 1124936000253 active site 1124936000254 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1124936000255 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1124936000256 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1124936000257 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1124936000258 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124936000259 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124936000260 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1124936000261 putative active site [active] 1124936000262 Ap4A binding site [chemical binding]; other site 1124936000263 nudix motif; other site 1124936000264 putative metal binding site [ion binding]; other site 1124936000265 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1124936000266 putative DNA-binding cleft [nucleotide binding]; other site 1124936000267 putative DNA clevage site; other site 1124936000268 molecular lever; other site 1124936000269 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1124936000270 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124936000271 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936000272 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936000273 active site 1124936000274 catalytic tetrad [active] 1124936000275 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1124936000276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000277 putative substrate translocation pore; other site 1124936000278 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1124936000279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124936000280 putative acyl-acceptor binding pocket; other site 1124936000281 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1124936000282 acyl-activating enzyme (AAE) consensus motif; other site 1124936000283 putative AMP binding site [chemical binding]; other site 1124936000284 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1124936000285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936000286 DNA binding site [nucleotide binding] 1124936000287 domain linker motif; other site 1124936000288 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1124936000289 dimerization interface (closed form) [polypeptide binding]; other site 1124936000290 ligand binding site [chemical binding]; other site 1124936000291 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124936000292 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936000293 DNA binding site [nucleotide binding] 1124936000294 domain linker motif; other site 1124936000295 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1124936000296 dimerization interface (closed form) [polypeptide binding]; other site 1124936000297 ligand binding site [chemical binding]; other site 1124936000298 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1124936000299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1124936000300 active site 1124936000301 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936000302 substrate binding site [chemical binding]; other site 1124936000303 catalytic residues [active] 1124936000304 dimer interface [polypeptide binding]; other site 1124936000305 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1124936000306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936000307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936000308 dimerization interface [polypeptide binding]; other site 1124936000309 putative racemase; Provisional; Region: PRK10200 1124936000310 aspartate racemase; Region: asp_race; TIGR00035 1124936000311 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1124936000312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000313 putative substrate translocation pore; other site 1124936000314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000315 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1124936000316 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1124936000317 NADP binding site [chemical binding]; other site 1124936000318 homodimer interface [polypeptide binding]; other site 1124936000319 active site 1124936000320 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1124936000321 putative acyltransferase; Provisional; Region: PRK05790 1124936000322 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124936000323 dimer interface [polypeptide binding]; other site 1124936000324 active site 1124936000325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936000326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936000327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936000328 dimerization interface [polypeptide binding]; other site 1124936000329 Predicted membrane protein [Function unknown]; Region: COG4125 1124936000330 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1124936000331 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1124936000332 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124936000333 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1124936000334 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1124936000335 putative metal binding site [ion binding]; other site 1124936000336 putative homodimer interface [polypeptide binding]; other site 1124936000337 putative homotetramer interface [polypeptide binding]; other site 1124936000338 putative homodimer-homodimer interface [polypeptide binding]; other site 1124936000339 putative allosteric switch controlling residues; other site 1124936000340 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1124936000341 transcriptional activator SprB; Provisional; Region: PRK15320 1124936000342 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 1124936000343 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1124936000344 potential frameshift: common BLAST hit: gi|386592720|ref|YP_006089120.1| Fimbrial OM outer membrane protein 1124936000345 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1124936000346 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936000347 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936000348 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1124936000349 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936000350 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936000351 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936000352 fimbrial protein StdA; Provisional; Region: PRK15210 1124936000353 hypothetical protein; Provisional; Region: PRK10316 1124936000354 YfdX protein; Region: YfdX; pfam10938 1124936000355 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1124936000356 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1124936000357 tetramer interface [polypeptide binding]; other site 1124936000358 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124936000359 active site 1124936000360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1124936000361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124936000362 NAD(P) binding site [chemical binding]; other site 1124936000363 active site 1124936000364 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1124936000365 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1124936000366 substrate binding site [chemical binding]; other site 1124936000367 hexamer interface [polypeptide binding]; other site 1124936000368 metal binding site [ion binding]; metal-binding site 1124936000369 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1124936000370 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1124936000371 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1124936000372 active site 1124936000373 P-loop; other site 1124936000374 phosphorylation site [posttranslational modification] 1124936000375 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936000376 active site 1124936000377 phosphorylation site [posttranslational modification] 1124936000378 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936000379 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936000380 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936000381 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1124936000382 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1124936000383 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1124936000384 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1124936000385 active site 1124936000386 P-loop; other site 1124936000387 phosphorylation site [posttranslational modification] 1124936000388 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936000389 active site 1124936000390 phosphorylation site [posttranslational modification] 1124936000391 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1124936000392 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1124936000393 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1124936000394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936000395 dimerization interface [polypeptide binding]; other site 1124936000396 putative DNA binding site [nucleotide binding]; other site 1124936000397 putative Zn2+ binding site [ion binding]; other site 1124936000398 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1124936000399 active site 1124936000400 Int/Topo IB signature motif; other site 1124936000401 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936000402 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124936000403 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1124936000404 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1124936000405 active site 1124936000406 metal binding site [ion binding]; metal-binding site 1124936000407 nudix motif; other site 1124936000408 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1124936000409 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1124936000410 dimer interface [polypeptide binding]; other site 1124936000411 putative anticodon binding site; other site 1124936000412 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1124936000413 motif 1; other site 1124936000414 active site 1124936000415 motif 2; other site 1124936000416 motif 3; other site 1124936000417 potential frameshift: common BLAST hit: gi|197363916|ref|YP_002143553.1| peptide chain release factor 2 1124936000418 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1124936000419 DHH family; Region: DHH; pfam01368 1124936000420 DHHA1 domain; Region: DHHA1; pfam02272 1124936000421 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1124936000422 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1124936000423 dimerization domain [polypeptide binding]; other site 1124936000424 dimer interface [polypeptide binding]; other site 1124936000425 catalytic residues [active] 1124936000426 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1124936000427 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1124936000428 active site 1124936000429 Int/Topo IB signature motif; other site 1124936000430 flavodoxin FldB; Provisional; Region: PRK12359 1124936000431 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1124936000432 hypothetical protein; Provisional; Region: PRK10878 1124936000433 putative global regulator; Reviewed; Region: PRK09559 1124936000434 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1124936000435 hemolysin; Provisional; Region: PRK15087 1124936000436 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1124936000437 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1124936000438 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1124936000439 beta-galactosidase; Region: BGL; TIGR03356 1124936000440 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1124936000441 glycine dehydrogenase; Provisional; Region: PRK05367 1124936000442 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1124936000443 tetramer interface [polypeptide binding]; other site 1124936000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936000445 catalytic residue [active] 1124936000446 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1124936000447 tetramer interface [polypeptide binding]; other site 1124936000448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936000449 catalytic residue [active] 1124936000450 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1124936000451 lipoyl attachment site [posttranslational modification]; other site 1124936000452 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1124936000453 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1124936000454 oxidoreductase; Provisional; Region: PRK08013 1124936000455 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1124936000456 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1124936000457 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1124936000458 proline aminopeptidase P II; Provisional; Region: PRK10879 1124936000459 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1124936000460 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1124936000461 active site 1124936000462 hypothetical protein; Reviewed; Region: PRK01736 1124936000463 Z-ring-associated protein; Provisional; Region: PRK10972 1124936000464 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1124936000465 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1124936000466 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1124936000467 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1124936000468 ligand binding site [chemical binding]; other site 1124936000469 NAD binding site [chemical binding]; other site 1124936000470 tetramer interface [polypeptide binding]; other site 1124936000471 catalytic site [active] 1124936000472 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1124936000473 L-serine binding site [chemical binding]; other site 1124936000474 ACT domain interface; other site 1124936000475 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1124936000476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124936000477 active site 1124936000478 dimer interface [polypeptide binding]; other site 1124936000479 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1124936000480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936000481 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1124936000482 putative dimerization interface [polypeptide binding]; other site 1124936000483 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1124936000484 oxidative stress defense protein; Provisional; Region: PRK11087 1124936000485 arginine exporter protein; Provisional; Region: PRK09304 1124936000486 mechanosensitive channel MscS; Provisional; Region: PRK10334 1124936000487 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936000488 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1124936000489 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1124936000490 active site 1124936000491 intersubunit interface [polypeptide binding]; other site 1124936000492 zinc binding site [ion binding]; other site 1124936000493 Na+ binding site [ion binding]; other site 1124936000494 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1124936000495 Phosphoglycerate kinase; Region: PGK; pfam00162 1124936000496 substrate binding site [chemical binding]; other site 1124936000497 hinge regions; other site 1124936000498 ADP binding site [chemical binding]; other site 1124936000499 catalytic site [active] 1124936000500 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1124936000501 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1124936000502 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1124936000503 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1124936000504 trimer interface [polypeptide binding]; other site 1124936000505 putative Zn binding site [ion binding]; other site 1124936000506 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1124936000507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1124936000508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1124936000509 Walker A/P-loop; other site 1124936000510 ATP binding site [chemical binding]; other site 1124936000511 Q-loop/lid; other site 1124936000512 ABC transporter signature motif; other site 1124936000513 Walker B; other site 1124936000514 D-loop; other site 1124936000515 H-loop/switch region; other site 1124936000516 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1124936000517 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1124936000518 Walker A/P-loop; other site 1124936000519 ATP binding site [chemical binding]; other site 1124936000520 Q-loop/lid; other site 1124936000521 ABC transporter signature motif; other site 1124936000522 Walker B; other site 1124936000523 D-loop; other site 1124936000524 H-loop/switch region; other site 1124936000525 transketolase; Reviewed; Region: PRK12753 1124936000526 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1124936000527 TPP-binding site [chemical binding]; other site 1124936000528 dimer interface [polypeptide binding]; other site 1124936000529 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1124936000530 PYR/PP interface [polypeptide binding]; other site 1124936000531 dimer interface [polypeptide binding]; other site 1124936000532 TPP binding site [chemical binding]; other site 1124936000533 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124936000534 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1124936000535 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1124936000536 agmatinase; Region: agmatinase; TIGR01230 1124936000537 oligomer interface [polypeptide binding]; other site 1124936000538 putative active site [active] 1124936000539 Mn binding site [ion binding]; other site 1124936000540 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124936000541 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1124936000542 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1124936000543 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1124936000544 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1124936000545 putative NAD(P) binding site [chemical binding]; other site 1124936000546 catalytic Zn binding site [ion binding]; other site 1124936000547 structural Zn binding site [ion binding]; other site 1124936000548 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1124936000549 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1124936000550 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1124936000551 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1124936000552 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124936000553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936000554 DNA-binding site [nucleotide binding]; DNA binding site 1124936000555 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124936000556 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1124936000557 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1124936000558 dimer interface [polypeptide binding]; other site 1124936000559 active site 1124936000560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936000561 catalytic residues [active] 1124936000562 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1124936000563 Virulence promoting factor; Region: YqgB; pfam11036 1124936000564 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1124936000565 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1124936000566 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1124936000567 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1124936000568 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1124936000569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000570 putative substrate translocation pore; other site 1124936000571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000572 hypothetical protein; Provisional; Region: PRK04860 1124936000573 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1124936000574 DNA-specific endonuclease I; Provisional; Region: PRK15137 1124936000575 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1124936000576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1124936000577 RNA methyltransferase, RsmE family; Region: TIGR00046 1124936000578 glutathione synthetase; Provisional; Region: PRK05246 1124936000579 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1124936000580 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1124936000581 hypothetical protein; Validated; Region: PRK00228 1124936000582 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1124936000583 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1124936000584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124936000585 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1124936000586 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1124936000587 Walker A motif; other site 1124936000588 ATP binding site [chemical binding]; other site 1124936000589 Walker B motif; other site 1124936000590 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1124936000591 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936000592 catalytic residue [active] 1124936000593 YGGT family; Region: YGGT; pfam02325 1124936000594 YGGT family; Region: YGGT; pfam02325 1124936000595 hypothetical protein; Validated; Region: PRK05090 1124936000596 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1124936000597 active site 1124936000598 dimerization interface [polypeptide binding]; other site 1124936000599 HemN family oxidoreductase; Provisional; Region: PRK05660 1124936000600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936000601 FeS/SAM binding site; other site 1124936000602 HemN C-terminal domain; Region: HemN_C; pfam06969 1124936000603 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1124936000604 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1124936000605 homodimer interface [polypeptide binding]; other site 1124936000606 active site 1124936000607 hypothetical protein; Provisional; Region: PRK10626 1124936000608 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1124936000609 hypothetical protein; Provisional; Region: PRK11702 1124936000610 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1124936000611 adenine DNA glycosylase; Provisional; Region: PRK10880 1124936000612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124936000613 minor groove reading motif; other site 1124936000614 helix-hairpin-helix signature motif; other site 1124936000615 substrate binding pocket [chemical binding]; other site 1124936000616 active site 1124936000617 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1124936000618 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1124936000619 DNA binding and oxoG recognition site [nucleotide binding] 1124936000620 oxidative damage protection protein; Provisional; Region: PRK05408 1124936000621 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1124936000622 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1124936000623 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936000624 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936000625 catalytic residue [active] 1124936000626 nucleoside transporter; Region: 2A0110; TIGR00889 1124936000627 ornithine decarboxylase; Provisional; Region: PRK13578 1124936000628 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1124936000629 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1124936000630 homodimer interface [polypeptide binding]; other site 1124936000631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936000632 catalytic residue [active] 1124936000633 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1124936000634 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1124936000635 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1124936000636 dimer interface [polypeptide binding]; other site 1124936000637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124936000638 metal binding site [ion binding]; metal-binding site 1124936000639 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1124936000640 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1124936000641 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1124936000642 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1124936000643 putative active site [active] 1124936000644 putative catalytic site [active] 1124936000645 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1124936000646 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1124936000647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936000648 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1124936000649 putative dimerization interface [polypeptide binding]; other site 1124936000650 putative substrate binding pocket [chemical binding]; other site 1124936000651 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1124936000652 Sulfatase; Region: Sulfatase; pfam00884 1124936000653 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1124936000654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936000655 FeS/SAM binding site; other site 1124936000656 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124936000657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124936000658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936000659 DNA binding residues [nucleotide binding] 1124936000660 dimerization interface [polypeptide binding]; other site 1124936000661 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1124936000662 Amino acid permease; Region: AA_permease_2; pfam13520 1124936000663 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1124936000664 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124936000665 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124936000666 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1124936000667 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124936000668 NAD(P) binding site [chemical binding]; other site 1124936000669 catalytic residues [active] 1124936000670 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1124936000671 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1124936000672 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1124936000673 active site 1124936000674 catalytic site [active] 1124936000675 Zn binding site [ion binding]; other site 1124936000676 tetramer interface [polypeptide binding]; other site 1124936000677 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124936000678 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1124936000679 putative active site [active] 1124936000680 catalytic triad [active] 1124936000681 putative dimer interface [polypeptide binding]; other site 1124936000682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936000683 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936000684 putative substrate translocation pore; other site 1124936000685 mannonate dehydratase; Provisional; Region: PRK03906 1124936000686 mannonate dehydratase; Region: uxuA; TIGR00695 1124936000687 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1124936000688 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1124936000689 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1124936000690 Glucuronate isomerase; Region: UxaC; pfam02614 1124936000691 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1124936000692 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936000693 dimer interface [polypeptide binding]; other site 1124936000694 putative CheW interface [polypeptide binding]; other site 1124936000695 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1124936000696 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1124936000697 CHAP domain; Region: CHAP; pfam05257 1124936000698 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1124936000699 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1124936000700 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1124936000701 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1124936000702 dimer interface [polypeptide binding]; other site 1124936000703 N-terminal domain interface [polypeptide binding]; other site 1124936000704 active site 1124936000705 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1124936000706 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1124936000707 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1124936000708 putative ligand binding residues [chemical binding]; other site 1124936000709 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1124936000710 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1124936000711 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1124936000712 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1124936000713 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1124936000714 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1124936000715 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1124936000716 putative substrate-binding site; other site 1124936000717 nickel binding site [ion binding]; other site 1124936000718 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1124936000719 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1124936000720 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1124936000721 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1124936000722 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1124936000723 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1124936000724 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1124936000725 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1124936000726 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1124936000727 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1124936000728 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1124936000729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936000730 dimerization interface [polypeptide binding]; other site 1124936000731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936000732 dimer interface [polypeptide binding]; other site 1124936000733 putative CheW interface [polypeptide binding]; other site 1124936000734 hypothetical protein; Provisional; Region: PRK05208 1124936000735 oxidoreductase; Provisional; Region: PRK07985 1124936000736 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1124936000737 NAD binding site [chemical binding]; other site 1124936000738 metal binding site [ion binding]; metal-binding site 1124936000739 active site 1124936000740 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1124936000741 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124936000742 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1124936000743 cystathionine beta-lyase; Provisional; Region: PRK08114 1124936000744 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1124936000745 homodimer interface [polypeptide binding]; other site 1124936000746 substrate-cofactor binding pocket; other site 1124936000747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936000748 catalytic residue [active] 1124936000749 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124936000750 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1124936000751 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1124936000752 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124936000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936000754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936000755 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1124936000756 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1124936000757 dimer interface [polypeptide binding]; other site 1124936000758 active site 1124936000759 metal binding site [ion binding]; metal-binding site 1124936000760 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936000761 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936000762 active site 1124936000763 catalytic tetrad [active] 1124936000764 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1124936000765 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1124936000766 transmembrane helices; other site 1124936000767 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1124936000768 nucleotide binding site/active site [active] 1124936000769 catalytic residue [active] 1124936000770 hypothetical protein; Provisional; Region: PRK01254 1124936000771 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1124936000772 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1124936000773 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1124936000774 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1124936000775 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1124936000776 DctM-like transporters; Region: DctM; pfam06808 1124936000777 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1124936000778 FtsI repressor; Provisional; Region: PRK10883 1124936000779 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1124936000780 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1124936000781 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1124936000782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124936000783 putative acyl-acceptor binding pocket; other site 1124936000784 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1124936000785 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1124936000786 CAP-like domain; other site 1124936000787 active site 1124936000788 primary dimer interface [polypeptide binding]; other site 1124936000789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936000790 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936000791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936000792 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1124936000793 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1124936000794 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1124936000795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936000796 active site 1124936000797 phosphorylation site [posttranslational modification] 1124936000798 intermolecular recognition site; other site 1124936000799 dimerization interface [polypeptide binding]; other site 1124936000800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936000801 DNA binding site [nucleotide binding] 1124936000802 sensor protein QseC; Provisional; Region: PRK10337 1124936000803 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1124936000804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936000805 dimer interface [polypeptide binding]; other site 1124936000806 phosphorylation site [posttranslational modification] 1124936000807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936000808 ATP binding site [chemical binding]; other site 1124936000809 Mg2+ binding site [ion binding]; other site 1124936000810 G-X-G motif; other site 1124936000811 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1124936000812 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1124936000813 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1124936000814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936000815 ATP binding site [chemical binding]; other site 1124936000816 Mg2+ binding site [ion binding]; other site 1124936000817 G-X-G motif; other site 1124936000818 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1124936000819 anchoring element; other site 1124936000820 dimer interface [polypeptide binding]; other site 1124936000821 ATP binding site [chemical binding]; other site 1124936000822 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1124936000823 active site 1124936000824 metal binding site [ion binding]; metal-binding site 1124936000825 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1124936000826 esterase YqiA; Provisional; Region: PRK11071 1124936000827 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1124936000828 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124936000829 active site 1124936000830 metal binding site [ion binding]; metal-binding site 1124936000831 hexamer interface [polypeptide binding]; other site 1124936000832 putative dehydrogenase; Provisional; Region: PRK11039 1124936000833 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1124936000834 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124936000835 dimer interface [polypeptide binding]; other site 1124936000836 ADP-ribose binding site [chemical binding]; other site 1124936000837 active site 1124936000838 nudix motif; other site 1124936000839 metal binding site [ion binding]; metal-binding site 1124936000840 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1124936000841 hypothetical protein; Provisional; Region: PRK11653 1124936000842 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1124936000843 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1124936000844 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1124936000845 putative active site [active] 1124936000846 metal binding site [ion binding]; metal-binding site 1124936000847 zinc transporter ZupT; Provisional; Region: PRK04201 1124936000848 ZIP Zinc transporter; Region: Zip; pfam02535 1124936000849 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1124936000850 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1124936000851 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1124936000852 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1124936000853 catalytic residues [active] 1124936000854 hinge region; other site 1124936000855 alpha helical domain; other site 1124936000856 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1124936000857 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1124936000858 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1124936000859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1124936000860 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1124936000861 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1124936000862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1124936000863 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1124936000864 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1124936000865 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1124936000866 putative ribose interaction site [chemical binding]; other site 1124936000867 putative ADP binding site [chemical binding]; other site 1124936000868 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1124936000869 active site 1124936000870 nucleotide binding site [chemical binding]; other site 1124936000871 HIGH motif; other site 1124936000872 KMSKS motif; other site 1124936000873 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1124936000874 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124936000875 metal binding triad; other site 1124936000876 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1124936000877 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124936000878 metal binding triad; other site 1124936000879 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1124936000880 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1124936000881 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1124936000882 putative active site [active] 1124936000883 putative metal binding residues [ion binding]; other site 1124936000884 signature motif; other site 1124936000885 putative triphosphate binding site [ion binding]; other site 1124936000886 CHAD domain; Region: CHAD; cl10506 1124936000887 SH3 domain-containing protein; Provisional; Region: PRK10884 1124936000888 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1124936000889 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1124936000890 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1124936000891 active site 1124936000892 NTP binding site [chemical binding]; other site 1124936000893 metal binding triad [ion binding]; metal-binding site 1124936000894 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1124936000895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124936000896 Zn2+ binding site [ion binding]; other site 1124936000897 Mg2+ binding site [ion binding]; other site 1124936000898 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1124936000899 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1124936000900 homooctamer interface [polypeptide binding]; other site 1124936000901 active site 1124936000902 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1124936000903 UGMP family protein; Validated; Region: PRK09604 1124936000904 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1124936000905 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1124936000906 DNA primase; Validated; Region: dnaG; PRK05667 1124936000907 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1124936000908 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1124936000909 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1124936000910 active site 1124936000911 metal binding site [ion binding]; metal-binding site 1124936000912 interdomain interaction site; other site 1124936000913 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1124936000914 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1124936000915 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1124936000916 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1124936000917 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1124936000918 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1124936000919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124936000920 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1124936000921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124936000922 DNA binding residues [nucleotide binding] 1124936000923 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1124936000924 active site 1124936000925 SUMO-1 interface [polypeptide binding]; other site 1124936000926 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1124936000927 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1124936000928 FAD binding pocket [chemical binding]; other site 1124936000929 FAD binding motif [chemical binding]; other site 1124936000930 phosphate binding motif [ion binding]; other site 1124936000931 NAD binding pocket [chemical binding]; other site 1124936000932 Predicted transcriptional regulators [Transcription]; Region: COG1695 1124936000933 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1124936000934 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124936000935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936000936 dimerization interface [polypeptide binding]; other site 1124936000937 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124936000938 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936000939 dimer interface [polypeptide binding]; other site 1124936000940 putative CheW interface [polypeptide binding]; other site 1124936000941 PAS fold; Region: PAS_3; pfam08447 1124936000942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936000943 putative active site [active] 1124936000944 heme pocket [chemical binding]; other site 1124936000945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124936000946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936000947 dimer interface [polypeptide binding]; other site 1124936000948 putative CheW interface [polypeptide binding]; other site 1124936000949 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1124936000950 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124936000951 inhibitor-cofactor binding pocket; inhibition site 1124936000952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936000953 catalytic residue [active] 1124936000954 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124936000955 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1124936000956 active site 1124936000957 FMN binding site [chemical binding]; other site 1124936000958 2,4-decadienoyl-CoA binding site; other site 1124936000959 catalytic residue [active] 1124936000960 4Fe-4S cluster binding site [ion binding]; other site 1124936000961 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1124936000962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936000963 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1124936000964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936000965 S-adenosylmethionine binding site [chemical binding]; other site 1124936000966 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1124936000967 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1124936000968 putative active site [active] 1124936000969 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124936000970 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124936000971 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1124936000972 serine/threonine transporter SstT; Provisional; Region: PRK13628 1124936000973 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124936000974 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124936000975 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1124936000976 potential frameshift: common BLAST hit: gi|409246947|ref|YP_006887649.1| Uncharacterized protein yqjB 1124936000977 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1124936000978 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1124936000979 Predicted membrane protein [Function unknown]; Region: COG5393 1124936000980 YqjK-like protein; Region: YqjK; pfam13997 1124936000981 Predicted membrane protein [Function unknown]; Region: COG2259 1124936000982 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1124936000983 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1124936000984 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1124936000985 putative dimer interface [polypeptide binding]; other site 1124936000986 N-terminal domain interface [polypeptide binding]; other site 1124936000987 putative substrate binding pocket (H-site) [chemical binding]; other site 1124936000988 Predicted membrane protein [Function unknown]; Region: COG3152 1124936000989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936000990 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1124936000991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936000992 dimerization interface [polypeptide binding]; other site 1124936000993 Pirin-related protein [General function prediction only]; Region: COG1741 1124936000994 Pirin; Region: Pirin; pfam02678 1124936000995 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1124936000996 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124936000997 serine transporter; Region: stp; TIGR00814 1124936000998 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1124936000999 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124936001000 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124936001001 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1124936001002 Pyruvate formate lyase 1; Region: PFL1; cd01678 1124936001003 coenzyme A binding site [chemical binding]; other site 1124936001004 active site 1124936001005 catalytic residues [active] 1124936001006 glycine loop; other site 1124936001007 propionate/acetate kinase; Provisional; Region: PRK12379 1124936001008 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1124936001009 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1124936001010 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124936001011 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1124936001012 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1124936001013 tetramer interface [polypeptide binding]; other site 1124936001014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936001015 catalytic residue [active] 1124936001016 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1124936001017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936001018 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1124936001019 putative substrate binding pocket [chemical binding]; other site 1124936001020 putative dimerization interface [polypeptide binding]; other site 1124936001021 glycerate kinase I; Provisional; Region: PRK10342 1124936001022 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1124936001023 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124936001024 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1124936001025 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1124936001026 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1124936001027 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1124936001028 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1124936001029 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1124936001030 intersubunit interface [polypeptide binding]; other site 1124936001031 active site 1124936001032 zinc binding site [ion binding]; other site 1124936001033 Na+ binding site [ion binding]; other site 1124936001034 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1124936001035 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936001036 active site 1124936001037 phosphorylation site [posttranslational modification] 1124936001038 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1124936001039 active site 1124936001040 P-loop; other site 1124936001041 phosphorylation site [posttranslational modification] 1124936001042 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1124936001043 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1124936001044 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1124936001045 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1124936001046 putative NAD(P) binding site [chemical binding]; other site 1124936001047 catalytic Zn binding site [ion binding]; other site 1124936001048 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936001049 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936001050 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936001051 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1124936001052 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1124936001053 putative SAM binding site [chemical binding]; other site 1124936001054 putative homodimer interface [polypeptide binding]; other site 1124936001055 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1124936001056 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1124936001057 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1124936001058 putative ligand binding site [chemical binding]; other site 1124936001059 TIGR00252 family protein; Region: TIGR00252 1124936001060 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1124936001061 dimer interface [polypeptide binding]; other site 1124936001062 active site 1124936001063 outer membrane lipoprotein; Provisional; Region: PRK11023 1124936001064 BON domain; Region: BON; pfam04972 1124936001065 BON domain; Region: BON; pfam04972 1124936001066 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1124936001067 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1124936001068 NAD binding site [chemical binding]; other site 1124936001069 active site 1124936001070 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1124936001071 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1124936001072 proposed catalytic triad [active] 1124936001073 conserved cys residue [active] 1124936001074 hypothetical protein; Provisional; Region: PRK03467 1124936001075 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1124936001076 GIY-YIG motif/motif A; other site 1124936001077 putative active site [active] 1124936001078 putative metal binding site [ion binding]; other site 1124936001079 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124936001080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936001081 Coenzyme A binding pocket [chemical binding]; other site 1124936001082 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1124936001083 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1124936001084 Peptidase family U32; Region: Peptidase_U32; pfam01136 1124936001085 putative protease; Provisional; Region: PRK15447 1124936001086 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1124936001087 hypothetical protein; Provisional; Region: PRK10508 1124936001088 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1124936001089 tryptophan permease; Provisional; Region: PRK10483 1124936001090 aromatic amino acid transport protein; Region: araaP; TIGR00837 1124936001091 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124936001092 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1124936001093 ATP binding site [chemical binding]; other site 1124936001094 Mg++ binding site [ion binding]; other site 1124936001095 motif III; other site 1124936001096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936001097 nucleotide binding region [chemical binding]; other site 1124936001098 ATP-binding site [chemical binding]; other site 1124936001099 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1124936001100 putative RNA binding site [nucleotide binding]; other site 1124936001101 lipoprotein NlpI; Provisional; Region: PRK11189 1124936001102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124936001103 binding surface 1124936001104 TPR motif; other site 1124936001105 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1124936001106 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1124936001107 RNase E interface [polypeptide binding]; other site 1124936001108 trimer interface [polypeptide binding]; other site 1124936001109 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1124936001110 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1124936001111 RNase E interface [polypeptide binding]; other site 1124936001112 trimer interface [polypeptide binding]; other site 1124936001113 active site 1124936001114 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1124936001115 putative nucleic acid binding region [nucleotide binding]; other site 1124936001116 G-X-X-G motif; other site 1124936001117 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1124936001118 RNA binding site [nucleotide binding]; other site 1124936001119 domain interface; other site 1124936001120 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1124936001121 16S/18S rRNA binding site [nucleotide binding]; other site 1124936001122 S13e-L30e interaction site [polypeptide binding]; other site 1124936001123 25S rRNA binding site [nucleotide binding]; other site 1124936001124 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1124936001125 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1124936001126 RNA binding site [nucleotide binding]; other site 1124936001127 active site 1124936001128 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1124936001129 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1124936001130 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1124936001131 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1124936001132 translation initiation factor IF-2; Region: IF-2; TIGR00487 1124936001133 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1124936001134 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1124936001135 G1 box; other site 1124936001136 putative GEF interaction site [polypeptide binding]; other site 1124936001137 GTP/Mg2+ binding site [chemical binding]; other site 1124936001138 Switch I region; other site 1124936001139 G2 box; other site 1124936001140 G3 box; other site 1124936001141 Switch II region; other site 1124936001142 G4 box; other site 1124936001143 G5 box; other site 1124936001144 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1124936001145 Translation-initiation factor 2; Region: IF-2; pfam11987 1124936001146 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1124936001147 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1124936001148 NusA N-terminal domain; Region: NusA_N; pfam08529 1124936001149 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1124936001150 RNA binding site [nucleotide binding]; other site 1124936001151 homodimer interface [polypeptide binding]; other site 1124936001152 NusA-like KH domain; Region: KH_5; pfam13184 1124936001153 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1124936001154 G-X-X-G motif; other site 1124936001155 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1124936001156 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1124936001157 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1124936001158 Sm and related proteins; Region: Sm_like; cl00259 1124936001159 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1124936001160 putative oligomer interface [polypeptide binding]; other site 1124936001161 putative RNA binding site [nucleotide binding]; other site 1124936001162 argininosuccinate synthase; Validated; Region: PRK05370 1124936001163 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1124936001164 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1124936001165 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1124936001166 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1124936001167 active site 1124936001168 substrate binding site [chemical binding]; other site 1124936001169 metal binding site [ion binding]; metal-binding site 1124936001170 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1124936001171 dihydropteroate synthase; Region: DHPS; TIGR01496 1124936001172 substrate binding pocket [chemical binding]; other site 1124936001173 dimer interface [polypeptide binding]; other site 1124936001174 inhibitor binding site; inhibition site 1124936001175 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1124936001176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936001177 Walker A motif; other site 1124936001178 ATP binding site [chemical binding]; other site 1124936001179 Walker B motif; other site 1124936001180 arginine finger; other site 1124936001181 Peptidase family M41; Region: Peptidase_M41; pfam01434 1124936001182 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1124936001183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936001184 S-adenosylmethionine binding site [chemical binding]; other site 1124936001185 RNA-binding protein YhbY; Provisional; Region: PRK10343 1124936001186 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1124936001187 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1124936001188 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124936001189 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1124936001190 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1124936001191 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1124936001192 GTP1/OBG; Region: GTP1_OBG; pfam01018 1124936001193 Obg GTPase; Region: Obg; cd01898 1124936001194 G1 box; other site 1124936001195 GTP/Mg2+ binding site [chemical binding]; other site 1124936001196 Switch I region; other site 1124936001197 G2 box; other site 1124936001198 G3 box; other site 1124936001199 Switch II region; other site 1124936001200 G4 box; other site 1124936001201 G5 box; other site 1124936001202 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124936001203 EamA-like transporter family; Region: EamA; pfam00892 1124936001204 EamA-like transporter family; Region: EamA; pfam00892 1124936001205 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1124936001206 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1124936001207 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1124936001208 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1124936001209 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1124936001210 substrate binding pocket [chemical binding]; other site 1124936001211 chain length determination region; other site 1124936001212 substrate-Mg2+ binding site; other site 1124936001213 catalytic residues [active] 1124936001214 aspartate-rich region 1; other site 1124936001215 active site lid residues [active] 1124936001216 aspartate-rich region 2; other site 1124936001217 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1124936001218 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1124936001219 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1124936001220 hinge; other site 1124936001221 active site 1124936001222 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1124936001223 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1124936001224 anti sigma factor interaction site; other site 1124936001225 regulatory phosphorylation site [posttranslational modification]; other site 1124936001226 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1124936001227 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1124936001228 mce related protein; Region: MCE; pfam02470 1124936001229 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1124936001230 conserved hypothetical integral membrane protein; Region: TIGR00056 1124936001231 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1124936001232 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1124936001233 Walker A/P-loop; other site 1124936001234 ATP binding site [chemical binding]; other site 1124936001235 Q-loop/lid; other site 1124936001236 ABC transporter signature motif; other site 1124936001237 Walker B; other site 1124936001238 D-loop; other site 1124936001239 H-loop/switch region; other site 1124936001240 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1124936001241 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1124936001242 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1124936001243 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1124936001244 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1124936001245 putative active site [active] 1124936001246 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1124936001247 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1124936001248 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1124936001249 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1124936001250 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1124936001251 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1124936001252 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1124936001253 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1124936001254 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1124936001255 Walker A/P-loop; other site 1124936001256 ATP binding site [chemical binding]; other site 1124936001257 Q-loop/lid; other site 1124936001258 ABC transporter signature motif; other site 1124936001259 Walker B; other site 1124936001260 D-loop; other site 1124936001261 H-loop/switch region; other site 1124936001262 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1124936001263 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1124936001264 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1124936001265 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1124936001266 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1124936001267 30S subunit binding site; other site 1124936001268 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936001269 active site 1124936001270 phosphorylation site [posttranslational modification] 1124936001271 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1124936001272 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124936001273 dimerization domain swap beta strand [polypeptide binding]; other site 1124936001274 regulatory protein interface [polypeptide binding]; other site 1124936001275 active site 1124936001276 regulatory phosphorylation site [posttranslational modification]; other site 1124936001277 hypothetical protein; Provisional; Region: PRK10345 1124936001278 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1124936001279 Transglycosylase; Region: Transgly; cl17702 1124936001280 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1124936001281 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1124936001282 conserved cys residue [active] 1124936001283 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1124936001284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936001285 putative active site [active] 1124936001286 heme pocket [chemical binding]; other site 1124936001287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936001288 dimer interface [polypeptide binding]; other site 1124936001289 phosphorylation site [posttranslational modification] 1124936001290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936001291 ATP binding site [chemical binding]; other site 1124936001292 Mg2+ binding site [ion binding]; other site 1124936001293 G-X-G motif; other site 1124936001294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936001295 active site 1124936001296 phosphorylation site [posttranslational modification] 1124936001297 intermolecular recognition site; other site 1124936001298 dimerization interface [polypeptide binding]; other site 1124936001299 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124936001300 putative binding surface; other site 1124936001301 active site 1124936001302 radical SAM protein, TIGR01212 family; Region: TIGR01212 1124936001303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936001304 FeS/SAM binding site; other site 1124936001305 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1124936001306 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1124936001307 active site 1124936001308 dimer interface [polypeptide binding]; other site 1124936001309 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1124936001310 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1124936001311 active site 1124936001312 FMN binding site [chemical binding]; other site 1124936001313 substrate binding site [chemical binding]; other site 1124936001314 3Fe-4S cluster binding site [ion binding]; other site 1124936001315 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1124936001316 domain interface; other site 1124936001317 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1124936001318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936001319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936001320 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1124936001321 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1124936001322 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1124936001323 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124936001324 Na binding site [ion binding]; other site 1124936001325 putative substrate binding site [chemical binding]; other site 1124936001326 cytosine deaminase; Provisional; Region: PRK09230 1124936001327 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1124936001328 active site 1124936001329 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1124936001330 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1124936001331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936001332 nucleotide binding site [chemical binding]; other site 1124936001333 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1124936001334 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1124936001335 putative active site cavity [active] 1124936001336 putative sialic acid transporter; Provisional; Region: PRK03893 1124936001337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936001338 putative substrate translocation pore; other site 1124936001339 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1124936001340 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1124936001341 inhibitor site; inhibition site 1124936001342 active site 1124936001343 dimer interface [polypeptide binding]; other site 1124936001344 catalytic residue [active] 1124936001345 transcriptional regulator NanR; Provisional; Region: PRK03837 1124936001346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936001347 DNA-binding site [nucleotide binding]; DNA binding site 1124936001348 FCD domain; Region: FCD; pfam07729 1124936001349 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1124936001350 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1124936001351 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1124936001352 C-terminal domain interface [polypeptide binding]; other site 1124936001353 putative GSH binding site (G-site) [chemical binding]; other site 1124936001354 dimer interface [polypeptide binding]; other site 1124936001355 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1124936001356 dimer interface [polypeptide binding]; other site 1124936001357 N-terminal domain interface [polypeptide binding]; other site 1124936001358 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1124936001359 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1124936001360 23S rRNA interface [nucleotide binding]; other site 1124936001361 L3 interface [polypeptide binding]; other site 1124936001362 Predicted ATPase [General function prediction only]; Region: COG1485 1124936001363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1124936001364 hypothetical protein; Provisional; Region: PRK11677 1124936001365 serine endoprotease; Provisional; Region: PRK10139 1124936001366 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1124936001367 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124936001368 protein binding site [polypeptide binding]; other site 1124936001369 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124936001370 serine endoprotease; Provisional; Region: PRK10898 1124936001371 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1124936001372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124936001373 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1124936001374 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1124936001375 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1124936001376 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1124936001377 active site 1124936001378 catalytic residues [active] 1124936001379 metal binding site [ion binding]; metal-binding site 1124936001380 homodimer binding site [polypeptide binding]; other site 1124936001381 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124936001382 carboxyltransferase (CT) interaction site; other site 1124936001383 biotinylation site [posttranslational modification]; other site 1124936001384 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1124936001385 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1124936001386 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1124936001387 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1124936001388 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1124936001389 transmembrane helices; other site 1124936001390 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124936001391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936001392 DNA-binding site [nucleotide binding]; DNA binding site 1124936001393 FCD domain; Region: FCD; pfam07729 1124936001394 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124936001395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936001396 DNA-binding site [nucleotide binding]; DNA binding site 1124936001397 malate dehydrogenase; Provisional; Region: PRK05086 1124936001398 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1124936001399 NAD binding site [chemical binding]; other site 1124936001400 dimerization interface [polypeptide binding]; other site 1124936001401 Substrate binding site [chemical binding]; other site 1124936001402 arginine repressor; Provisional; Region: PRK05066 1124936001403 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1124936001404 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1124936001405 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936001406 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936001407 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1124936001408 RNAase interaction site [polypeptide binding]; other site 1124936001409 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1124936001410 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124936001411 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1124936001412 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936001413 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936001414 efflux system membrane protein; Provisional; Region: PRK11594 1124936001415 transcriptional regulator; Provisional; Region: PRK10632 1124936001416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936001417 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124936001418 putative effector binding pocket; other site 1124936001419 dimerization interface [polypeptide binding]; other site 1124936001420 protease TldD; Provisional; Region: tldD; PRK10735 1124936001421 hypothetical protein; Provisional; Region: PRK10899 1124936001422 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1124936001423 ribonuclease G; Provisional; Region: PRK11712 1124936001424 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1124936001425 homodimer interface [polypeptide binding]; other site 1124936001426 oligonucleotide binding site [chemical binding]; other site 1124936001427 Maf-like protein; Region: Maf; pfam02545 1124936001428 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1124936001429 active site 1124936001430 dimer interface [polypeptide binding]; other site 1124936001431 rod shape-determining protein MreD; Provisional; Region: PRK11060 1124936001432 rod shape-determining protein MreC; Region: mreC; TIGR00219 1124936001433 rod shape-determining protein MreC; Region: MreC; pfam04085 1124936001434 rod shape-determining protein MreB; Provisional; Region: PRK13927 1124936001435 MreB and similar proteins; Region: MreB_like; cd10225 1124936001436 nucleotide binding site [chemical binding]; other site 1124936001437 Mg binding site [ion binding]; other site 1124936001438 putative protofilament interaction site [polypeptide binding]; other site 1124936001439 RodZ interaction site [polypeptide binding]; other site 1124936001440 regulatory protein CsrD; Provisional; Region: PRK11059 1124936001441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936001442 metal binding site [ion binding]; metal-binding site 1124936001443 active site 1124936001444 I-site; other site 1124936001445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936001446 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1124936001447 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1124936001448 NADP binding site [chemical binding]; other site 1124936001449 dimer interface [polypeptide binding]; other site 1124936001450 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1124936001451 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1124936001452 Moco binding site; other site 1124936001453 metal coordination site [ion binding]; other site 1124936001454 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1124936001455 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1124936001456 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124936001457 carboxyltransferase (CT) interaction site; other site 1124936001458 biotinylation site [posttranslational modification]; other site 1124936001459 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1124936001460 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124936001461 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124936001462 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124936001463 hypothetical protein; Provisional; Region: PRK10633 1124936001464 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1124936001465 Na binding site [ion binding]; other site 1124936001466 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1124936001467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124936001468 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1124936001469 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1124936001470 FMN binding site [chemical binding]; other site 1124936001471 active site 1124936001472 catalytic residues [active] 1124936001473 substrate binding site [chemical binding]; other site 1124936001474 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1124936001475 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1124936001476 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1124936001477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936001478 DNA methylase; Region: N6_N4_Mtase; pfam01555 1124936001479 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1124936001480 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1124936001481 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1124936001482 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1124936001483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936001484 metal binding site [ion binding]; metal-binding site 1124936001485 active site 1124936001486 I-site; other site 1124936001487 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936001488 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1124936001489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936001490 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1124936001491 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1124936001492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936001493 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936001494 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1124936001495 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1124936001496 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1124936001497 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1124936001498 trimer interface [polypeptide binding]; other site 1124936001499 putative metal binding site [ion binding]; other site 1124936001500 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1124936001501 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1124936001502 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1124936001503 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1124936001504 shikimate binding site; other site 1124936001505 NAD(P) binding site [chemical binding]; other site 1124936001506 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1124936001507 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124936001508 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1124936001509 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124936001510 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124936001511 hypothetical protein; Validated; Region: PRK03430 1124936001512 hypothetical protein; Provisional; Region: PRK10736 1124936001513 DNA protecting protein DprA; Region: dprA; TIGR00732 1124936001514 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1124936001515 active site 1124936001516 catalytic residues [active] 1124936001517 metal binding site [ion binding]; metal-binding site 1124936001518 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1124936001519 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1124936001520 putative active site [active] 1124936001521 substrate binding site [chemical binding]; other site 1124936001522 putative cosubstrate binding site; other site 1124936001523 catalytic site [active] 1124936001524 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1124936001525 substrate binding site [chemical binding]; other site 1124936001526 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1124936001527 putative RNA binding site [nucleotide binding]; other site 1124936001528 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1124936001529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936001530 S-adenosylmethionine binding site [chemical binding]; other site 1124936001531 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1124936001532 TrkA-N domain; Region: TrkA_N; pfam02254 1124936001533 TrkA-C domain; Region: TrkA_C; pfam02080 1124936001534 TrkA-N domain; Region: TrkA_N; pfam02254 1124936001535 TrkA-C domain; Region: TrkA_C; pfam02080 1124936001536 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1124936001537 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1124936001538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1124936001539 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1124936001540 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1124936001541 DNA binding residues [nucleotide binding] 1124936001542 dimer interface [polypeptide binding]; other site 1124936001543 metal binding site [ion binding]; metal-binding site 1124936001544 hypothetical protein; Provisional; Region: PRK10203 1124936001545 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1124936001546 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1124936001547 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1124936001548 alphaNTD homodimer interface [polypeptide binding]; other site 1124936001549 alphaNTD - beta interaction site [polypeptide binding]; other site 1124936001550 alphaNTD - beta' interaction site [polypeptide binding]; other site 1124936001551 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1124936001552 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1124936001553 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1124936001554 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936001555 RNA binding surface [nucleotide binding]; other site 1124936001556 30S ribosomal protein S11; Validated; Region: PRK05309 1124936001557 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1124936001558 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1124936001559 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1124936001560 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1124936001561 SecY translocase; Region: SecY; pfam00344 1124936001562 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1124936001563 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1124936001564 23S rRNA binding site [nucleotide binding]; other site 1124936001565 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1124936001566 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1124936001567 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1124936001568 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1124936001569 23S rRNA interface [nucleotide binding]; other site 1124936001570 5S rRNA interface [nucleotide binding]; other site 1124936001571 L27 interface [polypeptide binding]; other site 1124936001572 L5 interface [polypeptide binding]; other site 1124936001573 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1124936001574 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1124936001575 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1124936001576 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1124936001577 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1124936001578 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1124936001579 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1124936001580 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1124936001581 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1124936001582 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1124936001583 RNA binding site [nucleotide binding]; other site 1124936001584 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1124936001585 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1124936001586 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1124936001587 23S rRNA interface [nucleotide binding]; other site 1124936001588 putative translocon interaction site; other site 1124936001589 signal recognition particle (SRP54) interaction site; other site 1124936001590 L23 interface [polypeptide binding]; other site 1124936001591 trigger factor interaction site; other site 1124936001592 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1124936001593 23S rRNA interface [nucleotide binding]; other site 1124936001594 5S rRNA interface [nucleotide binding]; other site 1124936001595 putative antibiotic binding site [chemical binding]; other site 1124936001596 L25 interface [polypeptide binding]; other site 1124936001597 L27 interface [polypeptide binding]; other site 1124936001598 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1124936001599 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1124936001600 G-X-X-G motif; other site 1124936001601 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1124936001602 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1124936001603 protein-rRNA interface [nucleotide binding]; other site 1124936001604 putative translocon binding site; other site 1124936001605 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1124936001606 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1124936001607 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1124936001608 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1124936001609 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1124936001610 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1124936001611 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1124936001612 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1124936001613 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1124936001614 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1124936001615 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1124936001616 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1124936001617 heme binding site [chemical binding]; other site 1124936001618 ferroxidase pore; other site 1124936001619 ferroxidase diiron center [ion binding]; other site 1124936001620 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1124936001621 elongation factor Tu; Reviewed; Region: PRK00049 1124936001622 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1124936001623 G1 box; other site 1124936001624 GEF interaction site [polypeptide binding]; other site 1124936001625 GTP/Mg2+ binding site [chemical binding]; other site 1124936001626 Switch I region; other site 1124936001627 G2 box; other site 1124936001628 G3 box; other site 1124936001629 Switch II region; other site 1124936001630 G4 box; other site 1124936001631 G5 box; other site 1124936001632 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1124936001633 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1124936001634 Antibiotic Binding Site [chemical binding]; other site 1124936001635 elongation factor G; Reviewed; Region: PRK00007 1124936001636 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1124936001637 G1 box; other site 1124936001638 putative GEF interaction site [polypeptide binding]; other site 1124936001639 GTP/Mg2+ binding site [chemical binding]; other site 1124936001640 Switch I region; other site 1124936001641 G2 box; other site 1124936001642 G3 box; other site 1124936001643 Switch II region; other site 1124936001644 G4 box; other site 1124936001645 G5 box; other site 1124936001646 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1124936001647 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1124936001648 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1124936001649 30S ribosomal protein S7; Validated; Region: PRK05302 1124936001650 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1124936001651 S17 interaction site [polypeptide binding]; other site 1124936001652 S8 interaction site; other site 1124936001653 16S rRNA interaction site [nucleotide binding]; other site 1124936001654 streptomycin interaction site [chemical binding]; other site 1124936001655 23S rRNA interaction site [nucleotide binding]; other site 1124936001656 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1124936001657 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1124936001658 sulfur relay protein TusC; Validated; Region: PRK00211 1124936001659 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1124936001660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1124936001661 YheO-like PAS domain; Region: PAS_6; pfam08348 1124936001662 HTH domain; Region: HTH_22; pfam13309 1124936001663 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1124936001664 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1124936001665 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124936001666 phi X174 lysis protein; Provisional; Region: PRK02793 1124936001667 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1124936001668 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124936001669 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1124936001670 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1124936001671 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1124936001672 TrkA-N domain; Region: TrkA_N; pfam02254 1124936001673 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1124936001674 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1124936001675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936001676 Walker A/P-loop; other site 1124936001677 ATP binding site [chemical binding]; other site 1124936001678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936001679 ABC transporter signature motif; other site 1124936001680 Walker B; other site 1124936001681 D-loop; other site 1124936001682 ABC transporter; Region: ABC_tran_2; pfam12848 1124936001683 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936001684 putative monooxygenase; Provisional; Region: PRK11118 1124936001685 putative hydrolase; Provisional; Region: PRK10985 1124936001686 hypothetical protein; Provisional; Region: PRK04966 1124936001687 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1124936001688 active site 1124936001689 hypothetical protein; Provisional; Region: PRK10738 1124936001690 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1124936001691 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124936001692 ligand binding site [chemical binding]; other site 1124936001693 flexible hinge region; other site 1124936001694 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1124936001695 putative switch regulator; other site 1124936001696 non-specific DNA interactions [nucleotide binding]; other site 1124936001697 DNA binding site [nucleotide binding] 1124936001698 sequence specific DNA binding site [nucleotide binding]; other site 1124936001699 putative cAMP binding site [chemical binding]; other site 1124936001700 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1124936001701 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1124936001702 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124936001703 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1124936001704 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124936001705 inhibitor-cofactor binding pocket; inhibition site 1124936001706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936001707 catalytic residue [active] 1124936001708 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1124936001709 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1124936001710 glutamine binding [chemical binding]; other site 1124936001711 catalytic triad [active] 1124936001712 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1124936001713 cell filamentation protein Fic; Provisional; Region: PRK10347 1124936001714 hypothetical protein; Provisional; Region: PRK10204 1124936001715 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1124936001716 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1124936001717 substrate binding site [chemical binding]; other site 1124936001718 putative transporter; Provisional; Region: PRK03699 1124936001719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936001720 putative substrate translocation pore; other site 1124936001721 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1124936001722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936001723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124936001724 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124936001725 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124936001726 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1124936001727 nitrite transporter NirC; Provisional; Region: PRK11562 1124936001728 siroheme synthase; Provisional; Region: cysG; PRK10637 1124936001729 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1124936001730 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1124936001731 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1124936001732 active site 1124936001733 SAM binding site [chemical binding]; other site 1124936001734 homodimer interface [polypeptide binding]; other site 1124936001735 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1124936001736 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1124936001737 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1124936001738 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1124936001739 active site 1124936001740 HIGH motif; other site 1124936001741 dimer interface [polypeptide binding]; other site 1124936001742 KMSKS motif; other site 1124936001743 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1124936001744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936001745 motif II; other site 1124936001746 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1124936001747 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1124936001748 substrate binding site [chemical binding]; other site 1124936001749 hexamer interface [polypeptide binding]; other site 1124936001750 metal binding site [ion binding]; metal-binding site 1124936001751 DNA adenine methylase; Provisional; Region: PRK10904 1124936001752 cell division protein DamX; Validated; Region: PRK10905 1124936001753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1124936001754 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1124936001755 active site 1124936001756 dimer interface [polypeptide binding]; other site 1124936001757 metal binding site [ion binding]; metal-binding site 1124936001758 shikimate kinase; Reviewed; Region: aroK; PRK00131 1124936001759 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1124936001760 ADP binding site [chemical binding]; other site 1124936001761 magnesium binding site [ion binding]; other site 1124936001762 putative shikimate binding site; other site 1124936001763 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1124936001764 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124936001765 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1124936001766 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1124936001767 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1124936001768 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1124936001769 Transglycosylase; Region: Transgly; pfam00912 1124936001770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1124936001771 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1124936001772 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124936001773 ADP-ribose binding site [chemical binding]; other site 1124936001774 dimer interface [polypeptide binding]; other site 1124936001775 active site 1124936001776 nudix motif; other site 1124936001777 metal binding site [ion binding]; metal-binding site 1124936001778 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1124936001779 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1124936001780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936001781 motif II; other site 1124936001782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936001783 RNA binding surface [nucleotide binding]; other site 1124936001784 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1124936001785 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1124936001786 dimerization interface [polypeptide binding]; other site 1124936001787 domain crossover interface; other site 1124936001788 redox-dependent activation switch; other site 1124936001789 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1124936001790 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1124936001791 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1124936001792 active site 1124936001793 substrate-binding site [chemical binding]; other site 1124936001794 metal-binding site [ion binding] 1124936001795 ATP binding site [chemical binding]; other site 1124936001796 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1124936001797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936001798 dimerization interface [polypeptide binding]; other site 1124936001799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936001800 dimer interface [polypeptide binding]; other site 1124936001801 phosphorylation site [posttranslational modification] 1124936001802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936001803 ATP binding site [chemical binding]; other site 1124936001804 G-X-G motif; other site 1124936001805 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1124936001806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936001807 active site 1124936001808 phosphorylation site [posttranslational modification] 1124936001809 intermolecular recognition site; other site 1124936001810 dimerization interface [polypeptide binding]; other site 1124936001811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936001812 DNA binding site [nucleotide binding] 1124936001813 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1124936001814 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1124936001815 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124936001816 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1124936001817 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1124936001818 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1124936001819 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1124936001820 RNA binding site [nucleotide binding]; other site 1124936001821 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1124936001822 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1124936001823 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1124936001824 G1 box; other site 1124936001825 GTP/Mg2+ binding site [chemical binding]; other site 1124936001826 Switch I region; other site 1124936001827 G2 box; other site 1124936001828 G3 box; other site 1124936001829 Switch II region; other site 1124936001830 G4 box; other site 1124936001831 G5 box; other site 1124936001832 Nucleoside recognition; Region: Gate; pfam07670 1124936001833 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1124936001834 Nucleoside recognition; Region: Gate; pfam07670 1124936001835 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1124936001836 hypothetical protein; Provisional; Region: PRK09956 1124936001837 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1124936001838 carboxylesterase BioH; Provisional; Region: PRK10349 1124936001839 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1124936001840 DNA utilization protein GntX; Provisional; Region: PRK11595 1124936001841 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936001842 active site 1124936001843 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1124936001844 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1124936001845 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1124936001846 high-affinity gluconate transporter; Provisional; Region: PRK14984 1124936001847 gluconate transporter; Region: gntP; TIGR00791 1124936001848 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1124936001849 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1124936001850 maltodextrin phosphorylase; Provisional; Region: PRK14985 1124936001851 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1124936001852 homodimer interface [polypeptide binding]; other site 1124936001853 active site pocket [active] 1124936001854 transcriptional regulator MalT; Provisional; Region: PRK04841 1124936001855 AAA ATPase domain; Region: AAA_16; pfam13191 1124936001856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936001857 DNA binding residues [nucleotide binding] 1124936001858 dimerization interface [polypeptide binding]; other site 1124936001859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1124936001860 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1124936001861 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1124936001862 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1124936001863 putative active site [active] 1124936001864 adenylation catalytic residue [active] 1124936001865 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1124936001866 hypothetical protein; Reviewed; Region: PRK09588 1124936001867 TROVE domain; Region: TROVE; pfam05731 1124936001868 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1124936001869 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1124936001870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936001871 Walker A motif; other site 1124936001872 ATP binding site [chemical binding]; other site 1124936001873 Walker B motif; other site 1124936001874 arginine finger; other site 1124936001875 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1124936001876 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124936001877 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936001878 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1124936001879 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1124936001880 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1124936001881 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1124936001882 active site residue [active] 1124936001883 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1124936001884 hypothetical protein; Provisional; Region: PRK09781 1124936001885 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1124936001886 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1124936001887 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1124936001888 dimer interface [polypeptide binding]; other site 1124936001889 active site 1124936001890 metal binding site [ion binding]; metal-binding site 1124936001891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936001892 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936001893 putative substrate translocation pore; other site 1124936001894 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 1124936001895 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1124936001896 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1124936001897 inhibitor site; inhibition site 1124936001898 active site 1124936001899 dimer interface [polypeptide binding]; other site 1124936001900 catalytic residue [active] 1124936001901 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124936001902 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124936001903 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124936001904 glycogen phosphorylase; Provisional; Region: PRK14986 1124936001905 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1124936001906 homodimer interface [polypeptide binding]; other site 1124936001907 active site pocket [active] 1124936001908 glycogen synthase; Provisional; Region: glgA; PRK00654 1124936001909 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1124936001910 ADP-binding pocket [chemical binding]; other site 1124936001911 homodimer interface [polypeptide binding]; other site 1124936001912 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1124936001913 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1124936001914 ligand binding site; other site 1124936001915 oligomer interface; other site 1124936001916 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1124936001917 dimer interface [polypeptide binding]; other site 1124936001918 N-terminal domain interface [polypeptide binding]; other site 1124936001919 sulfate 1 binding site; other site 1124936001920 glycogen debranching enzyme; Provisional; Region: PRK03705 1124936001921 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1124936001922 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1124936001923 active site 1124936001924 catalytic site [active] 1124936001925 glycogen branching enzyme; Provisional; Region: PRK05402 1124936001926 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1124936001927 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1124936001928 active site 1124936001929 catalytic site [active] 1124936001930 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1124936001931 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1124936001932 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1124936001933 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1124936001934 low affinity gluconate transporter; Provisional; Region: PRK10472 1124936001935 gluconate transporter; Region: gntP; TIGR00791 1124936001936 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1124936001937 ATP-binding site [chemical binding]; other site 1124936001938 Gluconate-6-phosphate binding site [chemical binding]; other site 1124936001939 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1124936001940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936001941 DNA binding site [nucleotide binding] 1124936001942 domain linker motif; other site 1124936001943 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1124936001944 putative ligand binding site [chemical binding]; other site 1124936001945 putative dimerization interface [polypeptide binding]; other site 1124936001946 Pirin-related protein [General function prediction only]; Region: COG1741 1124936001947 Pirin; Region: Pirin; pfam02678 1124936001948 putative oxidoreductase; Provisional; Region: PRK10206 1124936001949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124936001950 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124936001951 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1124936001952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936001953 Coenzyme A binding pocket [chemical binding]; other site 1124936001954 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936001955 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936001956 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936001957 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1124936001958 substrate binding site [chemical binding]; other site 1124936001959 dimer interface [polypeptide binding]; other site 1124936001960 ATP binding site [chemical binding]; other site 1124936001961 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1124936001962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1124936001963 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1124936001964 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1124936001965 active site 1124936001966 substrate binding pocket [chemical binding]; other site 1124936001967 homodimer interaction site [polypeptide binding]; other site 1124936001968 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1124936001969 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1124936001970 hypothetical protein; Provisional; Region: PRK10350 1124936001971 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1124936001972 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1124936001973 putative active site [active] 1124936001974 catalytic site [active] 1124936001975 putative metal binding site [ion binding]; other site 1124936001976 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1124936001977 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1124936001978 Walker A/P-loop; other site 1124936001979 ATP binding site [chemical binding]; other site 1124936001980 Q-loop/lid; other site 1124936001981 ABC transporter signature motif; other site 1124936001982 Walker B; other site 1124936001983 D-loop; other site 1124936001984 H-loop/switch region; other site 1124936001985 TOBE domain; Region: TOBE_2; pfam08402 1124936001986 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1124936001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936001988 dimer interface [polypeptide binding]; other site 1124936001989 conserved gate region; other site 1124936001990 ABC-ATPase subunit interface; other site 1124936001991 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1124936001992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936001993 dimer interface [polypeptide binding]; other site 1124936001994 conserved gate region; other site 1124936001995 putative PBP binding loops; other site 1124936001996 ABC-ATPase subunit interface; other site 1124936001997 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1124936001998 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1124936001999 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1124936002000 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1124936002001 Walker A/P-loop; other site 1124936002002 ATP binding site [chemical binding]; other site 1124936002003 Q-loop/lid; other site 1124936002004 ABC transporter signature motif; other site 1124936002005 Walker B; other site 1124936002006 D-loop; other site 1124936002007 H-loop/switch region; other site 1124936002008 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1124936002009 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1124936002010 Walker A/P-loop; other site 1124936002011 ATP binding site [chemical binding]; other site 1124936002012 Q-loop/lid; other site 1124936002013 ABC transporter signature motif; other site 1124936002014 Walker B; other site 1124936002015 D-loop; other site 1124936002016 H-loop/switch region; other site 1124936002017 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1124936002018 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1124936002019 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1124936002020 TM-ABC transporter signature motif; other site 1124936002021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124936002022 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1124936002023 TM-ABC transporter signature motif; other site 1124936002024 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1124936002025 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1124936002026 dimerization interface [polypeptide binding]; other site 1124936002027 ligand binding site [chemical binding]; other site 1124936002028 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1124936002029 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1124936002030 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1124936002031 dimerization interface [polypeptide binding]; other site 1124936002032 ligand binding site [chemical binding]; other site 1124936002033 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1124936002034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124936002035 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124936002036 DNA binding residues [nucleotide binding] 1124936002037 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1124936002038 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1124936002039 cell division protein FtsE; Provisional; Region: PRK10908 1124936002040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936002041 Walker A/P-loop; other site 1124936002042 ATP binding site [chemical binding]; other site 1124936002043 Q-loop/lid; other site 1124936002044 ABC transporter signature motif; other site 1124936002045 Walker B; other site 1124936002046 D-loop; other site 1124936002047 H-loop/switch region; other site 1124936002048 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1124936002049 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1124936002050 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1124936002051 P loop; other site 1124936002052 GTP binding site [chemical binding]; other site 1124936002053 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1124936002054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936002055 S-adenosylmethionine binding site [chemical binding]; other site 1124936002056 hypothetical protein; Provisional; Region: PRK10910 1124936002057 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1124936002058 Predicted membrane protein [Function unknown]; Region: COG3714 1124936002059 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1124936002060 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124936002061 metal-binding site [ion binding] 1124936002062 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124936002063 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1124936002064 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1124936002065 dimer interface [polypeptide binding]; other site 1124936002066 ligand binding site [chemical binding]; other site 1124936002067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936002068 dimerization interface [polypeptide binding]; other site 1124936002069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936002070 dimer interface [polypeptide binding]; other site 1124936002071 putative CheW interface [polypeptide binding]; other site 1124936002072 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1124936002073 CPxP motif; other site 1124936002074 hypothetical protein; Provisional; Region: PRK11212 1124936002075 hypothetical protein; Provisional; Region: PRK11615 1124936002076 major facilitator superfamily transporter; Provisional; Region: PRK05122 1124936002077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002078 putative substrate translocation pore; other site 1124936002079 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1124936002080 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124936002081 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1124936002082 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1124936002083 nickel responsive regulator; Provisional; Region: PRK02967 1124936002084 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1124936002085 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124936002086 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124936002087 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124936002088 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1124936002089 Walker A/P-loop; other site 1124936002090 ATP binding site [chemical binding]; other site 1124936002091 Q-loop/lid; other site 1124936002092 ABC transporter signature motif; other site 1124936002093 Walker B; other site 1124936002094 D-loop; other site 1124936002095 H-loop/switch region; other site 1124936002096 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124936002097 Walker A/P-loop; other site 1124936002098 ATP binding site [chemical binding]; other site 1124936002099 Q-loop/lid; other site 1124936002100 ABC transporter signature motif; other site 1124936002101 Walker B; other site 1124936002102 D-loop; other site 1124936002103 H-loop/switch region; other site 1124936002104 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124936002105 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1124936002106 HlyD family secretion protein; Region: HlyD; pfam00529 1124936002107 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936002108 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936002109 Predicted flavoproteins [General function prediction only]; Region: COG2081 1124936002110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936002111 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1124936002112 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1124936002113 universal stress protein UspB; Provisional; Region: PRK04960 1124936002114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124936002115 Ligand Binding Site [chemical binding]; other site 1124936002116 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1124936002117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002118 putative substrate translocation pore; other site 1124936002119 POT family; Region: PTR2; pfam00854 1124936002120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936002121 S-adenosylmethionine binding site [chemical binding]; other site 1124936002122 oligopeptidase A; Provisional; Region: PRK10911 1124936002123 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1124936002124 active site 1124936002125 Zn binding site [ion binding]; other site 1124936002126 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1124936002127 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124936002128 active site 1124936002129 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1124936002130 glutathione reductase; Validated; Region: PRK06116 1124936002131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936002132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936002133 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124936002134 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1124936002135 active site 1124936002136 homodimer interface [polypeptide binding]; other site 1124936002137 homotetramer interface [polypeptide binding]; other site 1124936002138 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1124936002139 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1124936002140 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1124936002141 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936002142 substrate binding site [chemical binding]; other site 1124936002143 ATP binding site [chemical binding]; other site 1124936002144 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1124936002145 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1124936002146 putative active site [active] 1124936002147 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124936002148 dimer interface [polypeptide binding]; other site 1124936002149 active site 1124936002150 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1124936002151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936002152 DNA-binding site [nucleotide binding]; DNA binding site 1124936002153 UTRA domain; Region: UTRA; pfam07702 1124936002154 trehalase; Provisional; Region: treF; PRK13270 1124936002155 Trehalase; Region: Trehalase; pfam01204 1124936002156 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1124936002157 catalytic residue [active] 1124936002158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124936002159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1124936002160 active site 1124936002161 phosphorylation site [posttranslational modification] 1124936002162 dimerization interface [polypeptide binding]; other site 1124936002163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936002164 DNA binding residues [nucleotide binding] 1124936002165 dimerization interface [polypeptide binding]; other site 1124936002166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936002167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936002168 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1124936002169 putative effector binding pocket; other site 1124936002170 putative dimerization interface [polypeptide binding]; other site 1124936002171 inner membrane protein YhjD; Region: TIGR00766 1124936002172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002173 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124936002174 putative substrate translocation pore; other site 1124936002175 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1124936002176 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1124936002177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936002178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936002179 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1124936002180 substrate binding site [chemical binding]; other site 1124936002181 ATP binding site [chemical binding]; other site 1124936002182 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1124936002183 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124936002184 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1124936002185 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124936002186 putative diguanylate cyclase; Provisional; Region: PRK13561 1124936002187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936002188 metal binding site [ion binding]; metal-binding site 1124936002189 active site 1124936002190 I-site; other site 1124936002191 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936002192 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1124936002193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124936002194 TPR motif; other site 1124936002195 binding surface 1124936002196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124936002197 binding surface 1124936002198 TPR motif; other site 1124936002199 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1124936002200 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1124936002201 cellulose synthase regulator protein; Provisional; Region: PRK11114 1124936002202 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1124936002203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936002204 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1124936002205 DXD motif; other site 1124936002206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936002207 PilZ domain; Region: PilZ; pfam07238 1124936002208 cell division protein; Provisional; Region: PRK10037 1124936002209 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1124936002210 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1124936002211 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1124936002212 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1124936002213 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1124936002214 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1124936002215 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1124936002216 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124936002217 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124936002218 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1124936002219 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1124936002220 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936002221 Walker A/P-loop; other site 1124936002222 ATP binding site [chemical binding]; other site 1124936002223 Q-loop/lid; other site 1124936002224 ABC transporter signature motif; other site 1124936002225 Walker B; other site 1124936002226 D-loop; other site 1124936002227 H-loop/switch region; other site 1124936002228 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1124936002229 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1124936002230 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936002231 Walker A/P-loop; other site 1124936002232 ATP binding site [chemical binding]; other site 1124936002233 Q-loop/lid; other site 1124936002234 ABC transporter signature motif; other site 1124936002235 Walker B; other site 1124936002236 D-loop; other site 1124936002237 H-loop/switch region; other site 1124936002238 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1124936002239 dipeptide transporter; Provisional; Region: PRK10913 1124936002240 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1124936002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936002242 dimer interface [polypeptide binding]; other site 1124936002243 conserved gate region; other site 1124936002244 putative PBP binding loops; other site 1124936002245 ABC-ATPase subunit interface; other site 1124936002246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1124936002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936002248 dimer interface [polypeptide binding]; other site 1124936002249 conserved gate region; other site 1124936002250 putative PBP binding loops; other site 1124936002251 ABC-ATPase subunit interface; other site 1124936002252 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1124936002253 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1124936002254 peptide binding site [polypeptide binding]; other site 1124936002255 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1124936002256 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1124936002257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124936002258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936002259 DNA binding site [nucleotide binding] 1124936002260 domain linker motif; other site 1124936002261 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1124936002262 putative dimerization interface [polypeptide binding]; other site 1124936002263 putative ligand binding site [chemical binding]; other site 1124936002264 phosphoethanolamine transferase; Provisional; Region: PRK11560 1124936002265 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1124936002266 Sulfatase; Region: Sulfatase; pfam00884 1124936002267 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1124936002268 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 1124936002269 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 1124936002270 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936002271 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936002272 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936002273 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1124936002274 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936002275 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936002276 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1124936002277 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1124936002278 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1124936002279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936002280 Coenzyme A binding pocket [chemical binding]; other site 1124936002281 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1124936002282 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1124936002283 molybdopterin cofactor binding site [chemical binding]; other site 1124936002284 substrate binding site [chemical binding]; other site 1124936002285 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1124936002286 molybdopterin cofactor binding site; other site 1124936002287 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1124936002288 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124936002289 ligand binding site [chemical binding]; other site 1124936002290 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1124936002291 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1124936002292 dimerization interface [polypeptide binding]; other site 1124936002293 ligand binding site [chemical binding]; other site 1124936002294 NADP binding site [chemical binding]; other site 1124936002295 catalytic site [active] 1124936002296 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1124936002297 Predicted transcriptional regulator [Transcription]; Region: COG2944 1124936002298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936002299 salt bridge; other site 1124936002300 non-specific DNA binding site [nucleotide binding]; other site 1124936002301 sequence-specific DNA binding site [nucleotide binding]; other site 1124936002302 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124936002303 DNA-binding site [nucleotide binding]; DNA binding site 1124936002304 RNA-binding motif; other site 1124936002305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1124936002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1124936002307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124936002308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936002309 Coenzyme A binding pocket [chemical binding]; other site 1124936002310 Integrase core domain; Region: rve; pfam00665 1124936002311 Integrase core domain; Region: rve_2; pfam13333 1124936002312 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1124936002313 DALR anticodon binding domain; Region: DALR_1; pfam05746 1124936002314 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1124936002315 dimer interface [polypeptide binding]; other site 1124936002316 motif 1; other site 1124936002317 active site 1124936002318 motif 2; other site 1124936002319 motif 3; other site 1124936002320 YsaB-like lipoprotein; Region: YsaB; pfam13983 1124936002321 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1124936002322 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1124936002323 Predicted membrane protein [Function unknown]; Region: COG4682 1124936002324 yiaA/B two helix domain; Region: YiaAB; cl01759 1124936002325 yiaA/B two helix domain; Region: YiaAB; cl01759 1124936002326 xylulokinase; Provisional; Region: PRK15027 1124936002327 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1124936002328 N- and C-terminal domain interface [polypeptide binding]; other site 1124936002329 active site 1124936002330 MgATP binding site [chemical binding]; other site 1124936002331 catalytic site [active] 1124936002332 metal binding site [ion binding]; metal-binding site 1124936002333 xylulose binding site [chemical binding]; other site 1124936002334 homodimer interface [polypeptide binding]; other site 1124936002335 xylose isomerase; Provisional; Region: PRK05474 1124936002336 xylose isomerase; Region: xylose_isom_A; TIGR02630 1124936002337 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1124936002338 putative dimerization interface [polypeptide binding]; other site 1124936002339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124936002340 putative ligand binding site [chemical binding]; other site 1124936002341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936002342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936002343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936002344 hypothetical protein; Provisional; Region: PRK10356 1124936002345 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1124936002346 alpha-amylase; Reviewed; Region: malS; PRK09505 1124936002347 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1124936002348 active site 1124936002349 catalytic site [active] 1124936002350 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1124936002351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936002353 homodimer interface [polypeptide binding]; other site 1124936002354 catalytic residue [active] 1124936002355 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1124936002356 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124936002357 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124936002358 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124936002359 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1124936002360 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1124936002361 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1124936002362 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1124936002363 DctM-like transporters; Region: DctM; pfam06808 1124936002364 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1124936002365 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1124936002366 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1124936002367 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1124936002368 putative N- and C-terminal domain interface [polypeptide binding]; other site 1124936002369 putative active site [active] 1124936002370 MgATP binding site [chemical binding]; other site 1124936002371 catalytic site [active] 1124936002372 metal binding site [ion binding]; metal-binding site 1124936002373 putative xylulose binding site [chemical binding]; other site 1124936002374 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1124936002375 active site 1124936002376 dimer interface [polypeptide binding]; other site 1124936002377 magnesium binding site [ion binding]; other site 1124936002378 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1124936002379 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1124936002380 AP (apurinic/apyrimidinic) site pocket; other site 1124936002381 DNA interaction; other site 1124936002382 Metal-binding active site; metal-binding site 1124936002383 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1124936002384 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1124936002385 intersubunit interface [polypeptide binding]; other site 1124936002386 active site 1124936002387 Zn2+ binding site [ion binding]; other site 1124936002388 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124936002389 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124936002390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936002391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1124936002392 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1124936002393 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1124936002394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124936002395 NAD(P) binding site [chemical binding]; other site 1124936002396 catalytic residues [active] 1124936002397 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1124936002398 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936002399 nucleotide binding site [chemical binding]; other site 1124936002400 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1124936002401 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1124936002402 G1 box; other site 1124936002403 putative GEF interaction site [polypeptide binding]; other site 1124936002404 GTP/Mg2+ binding site [chemical binding]; other site 1124936002405 Switch I region; other site 1124936002406 G2 box; other site 1124936002407 G3 box; other site 1124936002408 Switch II region; other site 1124936002409 G4 box; other site 1124936002410 G5 box; other site 1124936002411 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1124936002412 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1124936002413 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1124936002414 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1124936002415 selenocysteine synthase; Provisional; Region: PRK04311 1124936002416 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1124936002417 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1124936002418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936002419 catalytic residue [active] 1124936002420 putative glutathione S-transferase; Provisional; Region: PRK10357 1124936002421 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1124936002422 putative C-terminal domain interface [polypeptide binding]; other site 1124936002423 putative GSH binding site (G-site) [chemical binding]; other site 1124936002424 putative dimer interface [polypeptide binding]; other site 1124936002425 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1124936002426 dimer interface [polypeptide binding]; other site 1124936002427 N-terminal domain interface [polypeptide binding]; other site 1124936002428 putative substrate binding pocket (H-site) [chemical binding]; other site 1124936002429 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1124936002430 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1124936002431 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1124936002432 active site 1124936002433 P-loop; other site 1124936002434 phosphorylation site [posttranslational modification] 1124936002435 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936002436 active site 1124936002437 phosphorylation site [posttranslational modification] 1124936002438 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1124936002439 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1124936002440 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1124936002441 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1124936002442 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1124936002443 hypothetical protein; Provisional; Region: PRK11020 1124936002444 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1124936002445 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1124936002446 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1124936002447 trimer interface [polypeptide binding]; other site 1124936002448 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1124936002449 Haemagglutinin; Region: HIM; pfam05662 1124936002450 Haemagglutinin; Region: HIM; pfam05662 1124936002451 YadA-like C-terminal region; Region: YadA; pfam03895 1124936002452 L-lactate permease; Provisional; Region: PRK10420 1124936002453 glycolate transporter; Provisional; Region: PRK09695 1124936002454 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1124936002455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936002456 DNA-binding site [nucleotide binding]; DNA binding site 1124936002457 FCD domain; Region: FCD; pfam07729 1124936002458 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1124936002459 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1124936002460 active site 1124936002461 substrate binding site [chemical binding]; other site 1124936002462 FMN binding site [chemical binding]; other site 1124936002463 putative catalytic residues [active] 1124936002464 putative rRNA methylase; Provisional; Region: PRK10358 1124936002465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124936002466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936002467 DNA binding site [nucleotide binding] 1124936002468 domain linker motif; other site 1124936002469 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1124936002470 putative dimerization interface [polypeptide binding]; other site 1124936002471 putative ligand binding site [chemical binding]; other site 1124936002472 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1124936002473 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1124936002474 active site pocket [active] 1124936002475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002476 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936002477 putative substrate translocation pore; other site 1124936002478 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1124936002479 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1124936002480 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1124936002481 trimer interface [polypeptide binding]; other site 1124936002482 active site 1124936002483 substrate binding site [chemical binding]; other site 1124936002484 CoA binding site [chemical binding]; other site 1124936002485 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1124936002486 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1124936002487 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1124936002488 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1124936002489 SecA binding site; other site 1124936002490 Preprotein binding site; other site 1124936002491 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1124936002492 GSH binding site [chemical binding]; other site 1124936002493 catalytic residues [active] 1124936002494 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1124936002495 active site residue [active] 1124936002496 phosphoglyceromutase; Provisional; Region: PRK05434 1124936002497 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1124936002498 AmiB activator; Provisional; Region: PRK11637 1124936002499 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1124936002500 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124936002501 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1124936002502 NodB motif; other site 1124936002503 putative active site [active] 1124936002504 putative catalytic site [active] 1124936002505 Zn binding site [ion binding]; other site 1124936002506 putative glycosyl transferase; Provisional; Region: PRK10073 1124936002507 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1124936002508 active site 1124936002509 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1124936002510 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1124936002511 NAD(P) binding site [chemical binding]; other site 1124936002512 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1124936002513 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1124936002514 substrate-cofactor binding pocket; other site 1124936002515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936002516 catalytic residue [active] 1124936002517 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1124936002518 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1124936002519 NADP binding site [chemical binding]; other site 1124936002520 homopentamer interface [polypeptide binding]; other site 1124936002521 substrate binding site [chemical binding]; other site 1124936002522 active site 1124936002523 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1124936002524 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1124936002525 putative active site [active] 1124936002526 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1124936002527 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1124936002528 putative active site [active] 1124936002529 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1124936002530 O-antigen ligase RfaL; Provisional; Region: PRK15487 1124936002531 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1124936002532 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1124936002533 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1124936002534 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1124936002535 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1124936002536 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1124936002537 Ligand binding site; other site 1124936002538 metal-binding site 1124936002539 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1124936002540 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1124936002541 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1124936002542 Ligand binding site; other site 1124936002543 metal-binding site 1124936002544 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1124936002545 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1124936002546 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1124936002547 putative ADP-binding pocket [chemical binding]; other site 1124936002548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936002549 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1124936002550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124936002551 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1124936002552 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1124936002553 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1124936002554 putative active site [active] 1124936002555 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1124936002556 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1124936002557 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124936002558 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1124936002559 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1124936002560 active site 1124936002561 (T/H)XGH motif; other site 1124936002562 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1124936002563 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1124936002564 DNA binding site [nucleotide binding] 1124936002565 catalytic residue [active] 1124936002566 H2TH interface [polypeptide binding]; other site 1124936002567 putative catalytic residues [active] 1124936002568 turnover-facilitating residue; other site 1124936002569 intercalation triad [nucleotide binding]; other site 1124936002570 8OG recognition residue [nucleotide binding]; other site 1124936002571 putative reading head residues; other site 1124936002572 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1124936002573 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1124936002574 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1124936002575 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1124936002576 hypothetical protein; Reviewed; Region: PRK00024 1124936002577 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1124936002578 MPN+ (JAMM) motif; other site 1124936002579 Zinc-binding site [ion binding]; other site 1124936002580 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1124936002581 Flavoprotein; Region: Flavoprotein; pfam02441 1124936002582 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1124936002583 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1124936002584 trimer interface [polypeptide binding]; other site 1124936002585 active site 1124936002586 division inhibitor protein; Provisional; Region: slmA; PRK09480 1124936002587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936002588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936002589 active site 1124936002590 ribonuclease PH; Reviewed; Region: rph; PRK00173 1124936002591 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1124936002592 hexamer interface [polypeptide binding]; other site 1124936002593 active site 1124936002594 hypothetical protein; Provisional; Region: PRK11820 1124936002595 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1124936002596 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1124936002597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936002598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936002599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936002600 dimerization interface [polypeptide binding]; other site 1124936002601 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1124936002602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124936002603 active site 1124936002604 Predicted membrane protein [Function unknown]; Region: COG2860 1124936002605 UPF0126 domain; Region: UPF0126; pfam03458 1124936002606 UPF0126 domain; Region: UPF0126; pfam03458 1124936002607 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1124936002608 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1124936002609 nucleotide binding pocket [chemical binding]; other site 1124936002610 K-X-D-G motif; other site 1124936002611 catalytic site [active] 1124936002612 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1124936002613 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1124936002614 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1124936002615 catalytic site [active] 1124936002616 G-X2-G-X-G-K; other site 1124936002617 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1124936002618 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1124936002619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124936002620 Zn2+ binding site [ion binding]; other site 1124936002621 Mg2+ binding site [ion binding]; other site 1124936002622 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1124936002623 synthetase active site [active] 1124936002624 NTP binding site [chemical binding]; other site 1124936002625 metal binding site [ion binding]; metal-binding site 1124936002626 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1124936002627 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1124936002628 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1124936002629 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1124936002630 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1124936002631 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1124936002632 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1124936002633 generic binding surface II; other site 1124936002634 ssDNA binding site; other site 1124936002635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936002636 ATP binding site [chemical binding]; other site 1124936002637 putative Mg++ binding site [ion binding]; other site 1124936002638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936002639 nucleotide binding region [chemical binding]; other site 1124936002640 ATP-binding site [chemical binding]; other site 1124936002641 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1124936002642 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1124936002643 AsmA family; Region: AsmA; pfam05170 1124936002644 putative alpha-glucosidase; Provisional; Region: PRK10658 1124936002645 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1124936002646 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1124936002647 active site 1124936002648 homotrimer interface [polypeptide binding]; other site 1124936002649 catalytic site [active] 1124936002650 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1124936002651 putative transporter; Provisional; Region: PRK11462 1124936002652 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1124936002653 integrase; Provisional; Region: PRK09692 1124936002654 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1124936002655 active site 1124936002656 Int/Topo IB signature motif; other site 1124936002657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936002658 ATP binding site [chemical binding]; other site 1124936002659 putative Mg++ binding site [ion binding]; other site 1124936002660 nucleotide binding region [chemical binding]; other site 1124936002661 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1124936002662 ATP-binding site [chemical binding]; other site 1124936002663 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1124936002664 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1124936002665 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1124936002666 Ash protein family; Region: Phage_ASH; pfam10554 1124936002667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1124936002668 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1124936002669 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1124936002670 active site 1124936002671 metal binding site [ion binding]; metal-binding site 1124936002672 interdomain interaction site; other site 1124936002673 D5 N terminal like; Region: D5_N; smart00885 1124936002674 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1124936002675 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1124936002676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936002677 AAA domain; Region: AAA_23; pfam13476 1124936002678 Walker A/P-loop; other site 1124936002679 ATP binding site [chemical binding]; other site 1124936002680 AAA domain; Region: AAA_21; pfam13304 1124936002681 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1124936002682 Virulence protein [General function prediction only]; Region: COG3943 1124936002683 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1124936002684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1124936002685 Transposase; Region: HTH_Tnp_1; pfam01527 1124936002686 autotransport protein MisL; Provisional; Region: PRK15313 1124936002687 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1124936002688 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1124936002689 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1124936002690 DNA binding site [nucleotide binding] 1124936002691 Isochorismatase family; Region: Isochorismatase; pfam00857 1124936002692 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1124936002693 catalytic triad [active] 1124936002694 dimer interface [polypeptide binding]; other site 1124936002695 conserved cis-peptide bond; other site 1124936002696 magnesium-transporting ATPase; Provisional; Region: PRK15122 1124936002697 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1124936002698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124936002699 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1124936002700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936002701 motif II; other site 1124936002702 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1124936002703 magnesium transport protein MgtC; Provisional; Region: PRK15385 1124936002704 MgtC family; Region: MgtC; pfam02308 1124936002705 EamA-like transporter family; Region: EamA; pfam00892 1124936002706 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124936002707 EamA-like transporter family; Region: EamA; pfam00892 1124936002708 hypothetical protein; Provisional; Region: PRK09956 1124936002709 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1124936002710 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1124936002711 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1124936002712 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1124936002713 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1124936002714 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1124936002715 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1124936002716 active site 1124936002717 phosphorylation site [posttranslational modification] 1124936002718 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936002719 active pocket/dimerization site; other site 1124936002720 active site 1124936002721 phosphorylation site [posttranslational modification] 1124936002722 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1124936002723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936002724 Walker A motif; other site 1124936002725 ATP binding site [chemical binding]; other site 1124936002726 Walker B motif; other site 1124936002727 arginine finger; other site 1124936002728 Transcriptional antiterminator [Transcription]; Region: COG3933 1124936002729 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1124936002730 active site 1124936002731 active pocket/dimerization site; other site 1124936002732 phosphorylation site [posttranslational modification] 1124936002733 PRD domain; Region: PRD; pfam00874 1124936002734 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1124936002735 beta-galactosidase; Region: BGL; TIGR03356 1124936002736 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1124936002737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002738 putative substrate translocation pore; other site 1124936002739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1124936002740 Predicted transcriptional regulator [Transcription]; Region: COG2944 1124936002741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936002742 non-specific DNA binding site [nucleotide binding]; other site 1124936002743 salt bridge; other site 1124936002744 sequence-specific DNA binding site [nucleotide binding]; other site 1124936002745 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124936002746 dimerization domain swap beta strand [polypeptide binding]; other site 1124936002747 regulatory protein interface [polypeptide binding]; other site 1124936002748 active site 1124936002749 regulatory phosphorylation site [posttranslational modification]; other site 1124936002750 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1124936002751 intersubunit interface [polypeptide binding]; other site 1124936002752 active site 1124936002753 zinc binding site [ion binding]; other site 1124936002754 Na+ binding site [ion binding]; other site 1124936002755 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1124936002756 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1124936002757 putative N- and C-terminal domain interface [polypeptide binding]; other site 1124936002758 putative active site [active] 1124936002759 putative MgATP binding site [chemical binding]; other site 1124936002760 catalytic site [active] 1124936002761 metal binding site [ion binding]; metal-binding site 1124936002762 putative carbohydrate binding site [chemical binding]; other site 1124936002763 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1124936002764 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1124936002765 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1124936002766 active site 1124936002767 P-loop; other site 1124936002768 phosphorylation site [posttranslational modification] 1124936002769 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936002770 active site 1124936002771 phosphorylation site [posttranslational modification] 1124936002772 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1124936002773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936002774 DNA-binding site [nucleotide binding]; DNA binding site 1124936002775 UTRA domain; Region: UTRA; pfam07702 1124936002776 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1124936002777 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1124936002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002779 putative substrate translocation pore; other site 1124936002780 regulatory protein UhpC; Provisional; Region: PRK11663 1124936002781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002782 putative substrate translocation pore; other site 1124936002783 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1124936002784 MASE1; Region: MASE1; pfam05231 1124936002785 Histidine kinase; Region: HisKA_3; pfam07730 1124936002786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936002787 ATP binding site [chemical binding]; other site 1124936002788 Mg2+ binding site [ion binding]; other site 1124936002789 G-X-G motif; other site 1124936002790 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1124936002791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936002792 active site 1124936002793 phosphorylation site [posttranslational modification] 1124936002794 intermolecular recognition site; other site 1124936002795 dimerization interface [polypeptide binding]; other site 1124936002796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936002797 DNA binding residues [nucleotide binding] 1124936002798 dimerization interface [polypeptide binding]; other site 1124936002799 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1124936002800 active site 1124936002801 catalytic residues [active] 1124936002802 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1124936002803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002804 putative substrate translocation pore; other site 1124936002805 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936002806 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1124936002807 substrate binding site [chemical binding]; other site 1124936002808 dimer interface [polypeptide binding]; other site 1124936002809 ATP binding site [chemical binding]; other site 1124936002810 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1124936002811 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1124936002812 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936002813 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1124936002814 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1124936002815 putative valine binding site [chemical binding]; other site 1124936002816 dimer interface [polypeptide binding]; other site 1124936002817 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1124936002818 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124936002819 PYR/PP interface [polypeptide binding]; other site 1124936002820 dimer interface [polypeptide binding]; other site 1124936002821 TPP binding site [chemical binding]; other site 1124936002822 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124936002823 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1124936002824 TPP-binding site [chemical binding]; other site 1124936002825 dimer interface [polypeptide binding]; other site 1124936002826 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1124936002827 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1124936002828 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1124936002829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002830 putative substrate translocation pore; other site 1124936002831 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1124936002832 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1124936002833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936002834 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124936002835 dimerization interface [polypeptide binding]; other site 1124936002836 substrate binding pocket [chemical binding]; other site 1124936002837 permease DsdX; Provisional; Region: PRK09921 1124936002838 gluconate transporter; Region: gntP; TIGR00791 1124936002839 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1124936002840 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1124936002841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936002842 catalytic residue [active] 1124936002843 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1124936002844 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124936002845 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1124936002846 Predicted membrane protein [Function unknown]; Region: COG2149 1124936002847 putative transporter; Validated; Region: PRK03818 1124936002848 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1124936002849 TrkA-C domain; Region: TrkA_C; pfam02080 1124936002850 TrkA-C domain; Region: TrkA_C; pfam02080 1124936002851 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1124936002852 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1124936002853 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1124936002854 putative dimer interface [polypeptide binding]; other site 1124936002855 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1124936002856 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1124936002857 putative dimer interface [polypeptide binding]; other site 1124936002858 hypothetical protein; Provisional; Region: PRK11616 1124936002859 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1124936002860 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1124936002861 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1124936002862 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1124936002863 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1124936002864 catalytic residues [active] 1124936002865 central insert; other site 1124936002866 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1124936002867 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1124936002868 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1124936002869 heme exporter protein CcmC; Region: ccmC; TIGR01191 1124936002870 heme exporter protein CcmB; Region: ccmB; TIGR01190 1124936002871 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1124936002872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936002873 Walker A/P-loop; other site 1124936002874 ATP binding site [chemical binding]; other site 1124936002875 Q-loop/lid; other site 1124936002876 ABC transporter signature motif; other site 1124936002877 Walker B; other site 1124936002878 D-loop; other site 1124936002879 H-loop/switch region; other site 1124936002880 Haem-binding domain; Region: Haem_bd; pfam14376 1124936002881 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1124936002882 chaperone protein TorD; Validated; Region: torD; PRK04976 1124936002883 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1124936002884 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1124936002885 molybdopterin cofactor binding site [chemical binding]; other site 1124936002886 substrate binding site [chemical binding]; other site 1124936002887 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1124936002888 molybdopterin cofactor binding site; other site 1124936002889 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1124936002890 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1124936002891 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1124936002892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936002893 active site 1124936002894 phosphorylation site [posttranslational modification] 1124936002895 intermolecular recognition site; other site 1124936002896 dimerization interface [polypeptide binding]; other site 1124936002897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936002898 DNA binding site [nucleotide binding] 1124936002899 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1124936002900 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1124936002901 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1124936002902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936002903 dimer interface [polypeptide binding]; other site 1124936002904 phosphorylation site [posttranslational modification] 1124936002905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936002906 ATP binding site [chemical binding]; other site 1124936002907 Mg2+ binding site [ion binding]; other site 1124936002908 G-X-G motif; other site 1124936002909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936002910 active site 1124936002911 phosphorylation site [posttranslational modification] 1124936002912 intermolecular recognition site; other site 1124936002913 dimerization interface [polypeptide binding]; other site 1124936002914 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124936002915 putative binding surface; other site 1124936002916 active site 1124936002917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002918 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936002919 putative substrate translocation pore; other site 1124936002920 galactonate dehydratase; Provisional; Region: PRK14017 1124936002921 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1124936002922 putative active site pocket [active] 1124936002923 putative metal binding site [ion binding]; other site 1124936002924 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1124936002925 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1124936002926 active site 1124936002927 intersubunit interface [polypeptide binding]; other site 1124936002928 catalytic residue [active] 1124936002929 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1124936002930 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1124936002931 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124936002932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936002933 DNA-binding site [nucleotide binding]; DNA binding site 1124936002934 FCD domain; Region: FCD; pfam07729 1124936002935 sugar phosphate phosphatase; Provisional; Region: PRK10513 1124936002936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936002937 active site 1124936002938 motif I; other site 1124936002939 motif II; other site 1124936002940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936002941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002942 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936002943 putative substrate translocation pore; other site 1124936002944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936002945 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1124936002946 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1124936002947 active site pocket [active] 1124936002948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936002949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936002950 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1124936002951 putative dimerization interface [polypeptide binding]; other site 1124936002952 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1124936002953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936002954 Mg2+ binding site [ion binding]; other site 1124936002955 G-X-G motif; other site 1124936002956 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1124936002957 anchoring element; other site 1124936002958 dimer interface [polypeptide binding]; other site 1124936002959 ATP binding site [chemical binding]; other site 1124936002960 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1124936002961 active site 1124936002962 putative metal-binding site [ion binding]; other site 1124936002963 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1124936002964 recF protein; Region: recf; TIGR00611 1124936002965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936002966 Walker A/P-loop; other site 1124936002967 ATP binding site [chemical binding]; other site 1124936002968 Q-loop/lid; other site 1124936002969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936002970 ABC transporter signature motif; other site 1124936002971 Walker B; other site 1124936002972 D-loop; other site 1124936002973 H-loop/switch region; other site 1124936002974 DNA polymerase III subunit beta; Validated; Region: PRK05643 1124936002975 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1124936002976 putative DNA binding surface [nucleotide binding]; other site 1124936002977 dimer interface [polypeptide binding]; other site 1124936002978 beta-clamp/clamp loader binding surface; other site 1124936002979 beta-clamp/translesion DNA polymerase binding surface; other site 1124936002980 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1124936002981 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1124936002982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936002983 Walker A motif; other site 1124936002984 ATP binding site [chemical binding]; other site 1124936002985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1124936002986 Walker B motif; other site 1124936002987 arginine finger; other site 1124936002988 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1124936002989 DnaA box-binding interface [nucleotide binding]; other site 1124936002990 ent-kaur-16-ene synthase; Region: PLN02279 1124936002991 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1124936002992 hypothetical protein; Validated; Region: PRK00041 1124936002993 membrane protein insertase; Provisional; Region: PRK01318 1124936002994 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1124936002995 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1124936002996 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1124936002997 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1124936002998 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1124936002999 G1 box; other site 1124936003000 GTP/Mg2+ binding site [chemical binding]; other site 1124936003001 Switch I region; other site 1124936003002 G2 box; other site 1124936003003 Switch II region; other site 1124936003004 G3 box; other site 1124936003005 G4 box; other site 1124936003006 G5 box; other site 1124936003007 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1124936003008 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1124936003009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936003010 putative substrate translocation pore; other site 1124936003011 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1124936003012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936003013 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124936003014 substrate binding pocket [chemical binding]; other site 1124936003015 dimerization interface [polypeptide binding]; other site 1124936003016 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1124936003017 Predicted flavoprotein [General function prediction only]; Region: COG0431 1124936003018 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124936003019 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1124936003020 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1124936003021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936003022 active site 1124936003023 motif I; other site 1124936003024 motif II; other site 1124936003025 transcriptional regulator PhoU; Provisional; Region: PRK11115 1124936003026 PhoU domain; Region: PhoU; pfam01895 1124936003027 PhoU domain; Region: PhoU; pfam01895 1124936003028 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1124936003029 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1124936003030 Walker A/P-loop; other site 1124936003031 ATP binding site [chemical binding]; other site 1124936003032 Q-loop/lid; other site 1124936003033 ABC transporter signature motif; other site 1124936003034 Walker B; other site 1124936003035 D-loop; other site 1124936003036 H-loop/switch region; other site 1124936003037 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1124936003038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936003039 dimer interface [polypeptide binding]; other site 1124936003040 conserved gate region; other site 1124936003041 putative PBP binding loops; other site 1124936003042 ABC-ATPase subunit interface; other site 1124936003043 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1124936003044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936003045 dimer interface [polypeptide binding]; other site 1124936003046 conserved gate region; other site 1124936003047 putative PBP binding loops; other site 1124936003048 ABC-ATPase subunit interface; other site 1124936003049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936003050 substrate binding pocket [chemical binding]; other site 1124936003051 membrane-bound complex binding site; other site 1124936003052 hinge residues; other site 1124936003053 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1124936003054 active site 1124936003055 P-loop; other site 1124936003056 phosphorylation site [posttranslational modification] 1124936003057 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1124936003058 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1124936003059 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1124936003060 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1124936003061 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1124936003062 shikimate binding site; other site 1124936003063 NAD(P) binding site [chemical binding]; other site 1124936003064 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1124936003065 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1124936003066 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1124936003067 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1124936003068 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1124936003069 glutaminase active site [active] 1124936003070 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1124936003071 dimer interface [polypeptide binding]; other site 1124936003072 active site 1124936003073 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124936003074 dimer interface [polypeptide binding]; other site 1124936003075 active site 1124936003076 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1124936003077 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1124936003078 Substrate binding site; other site 1124936003079 Mg++ binding site; other site 1124936003080 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1124936003081 active site 1124936003082 substrate binding site [chemical binding]; other site 1124936003083 CoA binding site [chemical binding]; other site 1124936003084 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1124936003085 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1124936003086 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1124936003087 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1124936003088 gamma subunit interface [polypeptide binding]; other site 1124936003089 epsilon subunit interface [polypeptide binding]; other site 1124936003090 LBP interface [polypeptide binding]; other site 1124936003091 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1124936003092 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1124936003093 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1124936003094 alpha subunit interaction interface [polypeptide binding]; other site 1124936003095 Walker A motif; other site 1124936003096 ATP binding site [chemical binding]; other site 1124936003097 Walker B motif; other site 1124936003098 inhibitor binding site; inhibition site 1124936003099 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1124936003100 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1124936003101 core domain interface [polypeptide binding]; other site 1124936003102 delta subunit interface [polypeptide binding]; other site 1124936003103 epsilon subunit interface [polypeptide binding]; other site 1124936003104 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1124936003105 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1124936003106 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1124936003107 beta subunit interaction interface [polypeptide binding]; other site 1124936003108 Walker A motif; other site 1124936003109 ATP binding site [chemical binding]; other site 1124936003110 Walker B motif; other site 1124936003111 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1124936003112 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1124936003113 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1124936003114 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1124936003115 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1124936003116 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1124936003117 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1124936003118 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1124936003119 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1124936003120 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1124936003121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936003122 S-adenosylmethionine binding site [chemical binding]; other site 1124936003123 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1124936003124 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1124936003125 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1124936003126 FMN-binding protein MioC; Provisional; Region: PRK09004 1124936003127 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1124936003128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936003129 putative DNA binding site [nucleotide binding]; other site 1124936003130 putative Zn2+ binding site [ion binding]; other site 1124936003131 AsnC family; Region: AsnC_trans_reg; pfam01037 1124936003132 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1124936003133 dimer interface [polypeptide binding]; other site 1124936003134 active site 1124936003135 hypothetical protein; Provisional; Region: yieM; PRK10997 1124936003136 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1124936003137 metal ion-dependent adhesion site (MIDAS); other site 1124936003138 regulatory ATPase RavA; Provisional; Region: PRK13531 1124936003139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936003140 Walker A motif; other site 1124936003141 ATP binding site [chemical binding]; other site 1124936003142 Walker B motif; other site 1124936003143 arginine finger; other site 1124936003144 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1124936003145 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1124936003146 potassium uptake protein; Region: kup; TIGR00794 1124936003147 D-ribose pyranase; Provisional; Region: PRK11797 1124936003148 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1124936003149 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1124936003150 Walker A/P-loop; other site 1124936003151 ATP binding site [chemical binding]; other site 1124936003152 Q-loop/lid; other site 1124936003153 ABC transporter signature motif; other site 1124936003154 Walker B; other site 1124936003155 D-loop; other site 1124936003156 H-loop/switch region; other site 1124936003157 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1124936003158 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124936003159 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1124936003160 TM-ABC transporter signature motif; other site 1124936003161 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1124936003162 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1124936003163 ligand binding site [chemical binding]; other site 1124936003164 dimerization interface [polypeptide binding]; other site 1124936003165 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936003166 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1124936003167 substrate binding site [chemical binding]; other site 1124936003168 dimer interface [polypeptide binding]; other site 1124936003169 ATP binding site [chemical binding]; other site 1124936003170 transcriptional repressor RbsR; Provisional; Region: PRK10423 1124936003171 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936003172 DNA binding site [nucleotide binding] 1124936003173 domain linker motif; other site 1124936003174 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1124936003175 dimerization interface [polypeptide binding]; other site 1124936003176 ligand binding site [chemical binding]; other site 1124936003177 putative transporter; Provisional; Region: PRK10504 1124936003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936003179 putative substrate translocation pore; other site 1124936003180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936003181 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124936003182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936003183 DNA-binding site [nucleotide binding]; DNA binding site 1124936003184 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124936003185 transcriptional regulator HdfR; Provisional; Region: PRK03601 1124936003186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936003187 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1124936003188 dimerization interface [polypeptide binding]; other site 1124936003189 hypothetical protein; Provisional; Region: PRK11027 1124936003190 putative ATP-dependent protease; Provisional; Region: PRK09862 1124936003191 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1124936003192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936003193 Walker A motif; other site 1124936003194 ATP binding site [chemical binding]; other site 1124936003195 Walker B motif; other site 1124936003196 arginine finger; other site 1124936003197 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1124936003198 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1124936003199 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124936003200 PYR/PP interface [polypeptide binding]; other site 1124936003201 dimer interface [polypeptide binding]; other site 1124936003202 TPP binding site [chemical binding]; other site 1124936003203 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124936003204 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1124936003205 TPP-binding site [chemical binding]; other site 1124936003206 dimer interface [polypeptide binding]; other site 1124936003207 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1124936003208 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1124936003209 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1124936003210 homodimer interface [polypeptide binding]; other site 1124936003211 substrate-cofactor binding pocket; other site 1124936003212 catalytic residue [active] 1124936003213 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1124936003214 threonine dehydratase; Reviewed; Region: PRK09224 1124936003215 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1124936003216 tetramer interface [polypeptide binding]; other site 1124936003217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936003218 catalytic residue [active] 1124936003219 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1124936003220 putative Ile/Val binding site [chemical binding]; other site 1124936003221 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1124936003222 putative Ile/Val binding site [chemical binding]; other site 1124936003223 Phage-related protein [Function unknown]; Region: COG4679 1124936003224 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1124936003225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936003226 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1124936003227 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1124936003228 putative dimerization interface [polypeptide binding]; other site 1124936003229 ketol-acid reductoisomerase; Validated; Region: PRK05225 1124936003230 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1124936003231 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1124936003232 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1124936003233 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1124936003234 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1124936003235 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1124936003236 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1124936003237 Part of AAA domain; Region: AAA_19; pfam13245 1124936003238 Family description; Region: UvrD_C_2; pfam13538 1124936003239 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1124936003240 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1124936003241 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1124936003242 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124936003243 ATP binding site [chemical binding]; other site 1124936003244 Mg++ binding site [ion binding]; other site 1124936003245 motif III; other site 1124936003246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936003247 nucleotide binding region [chemical binding]; other site 1124936003248 ATP-binding site [chemical binding]; other site 1124936003249 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1124936003250 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124936003251 catalytic residues [active] 1124936003252 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1124936003253 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1124936003254 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1124936003255 RNA binding site [nucleotide binding]; other site 1124936003256 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1124936003257 multimer interface [polypeptide binding]; other site 1124936003258 Walker A motif; other site 1124936003259 ATP binding site [chemical binding]; other site 1124936003260 Walker B motif; other site 1124936003261 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1124936003262 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1124936003263 Mg++ binding site [ion binding]; other site 1124936003264 putative catalytic motif [active] 1124936003265 substrate binding site [chemical binding]; other site 1124936003266 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1124936003267 Chain length determinant protein; Region: Wzz; pfam02706 1124936003268 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1124936003269 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1124936003270 active site 1124936003271 homodimer interface [polypeptide binding]; other site 1124936003272 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1124936003273 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1124936003274 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1124936003275 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1124936003276 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1124936003277 NAD binding site [chemical binding]; other site 1124936003278 substrate binding site [chemical binding]; other site 1124936003279 homodimer interface [polypeptide binding]; other site 1124936003280 active site 1124936003281 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1124936003282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936003283 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1124936003284 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1124936003285 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124936003286 inhibitor-cofactor binding pocket; inhibition site 1124936003287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936003288 catalytic residue [active] 1124936003289 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1124936003290 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1124936003291 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1124936003292 putative common antigen polymerase; Provisional; Region: PRK02975 1124936003293 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1124936003294 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1124936003295 putative transport protein YifK; Provisional; Region: PRK10746 1124936003296 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1124936003297 HemY protein N-terminus; Region: HemY_N; pfam07219 1124936003298 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1124936003299 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1124936003300 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1124936003301 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1124936003302 active site 1124936003303 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1124936003304 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1124936003305 domain interfaces; other site 1124936003306 active site 1124936003307 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1124936003308 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1124936003309 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1124936003310 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1124936003311 putative iron binding site [ion binding]; other site 1124936003312 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1124936003313 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1124936003314 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1124936003315 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1124936003316 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1124936003317 hypothetical protein; Provisional; Region: PRK10963 1124936003318 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1124936003319 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1124936003320 active site 1124936003321 Int/Topo IB signature motif; other site 1124936003322 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1124936003323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936003324 motif II; other site 1124936003325 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1124936003326 Part of AAA domain; Region: AAA_19; pfam13245 1124936003327 Family description; Region: UvrD_C_2; pfam13538 1124936003328 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1124936003329 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1124936003330 Cl binding site [ion binding]; other site 1124936003331 oligomer interface [polypeptide binding]; other site 1124936003332 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1124936003333 EamA-like transporter family; Region: EamA; cl17759 1124936003334 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124936003335 CoenzymeA binding site [chemical binding]; other site 1124936003336 subunit interaction site [polypeptide binding]; other site 1124936003337 PHB binding site; other site 1124936003338 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1124936003339 dimerization interface [polypeptide binding]; other site 1124936003340 substrate binding site [chemical binding]; other site 1124936003341 active site 1124936003342 calcium binding site [ion binding]; other site 1124936003343 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1124936003344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936003345 ATP binding site [chemical binding]; other site 1124936003346 putative Mg++ binding site [ion binding]; other site 1124936003347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936003348 nucleotide binding region [chemical binding]; other site 1124936003349 ATP-binding site [chemical binding]; other site 1124936003350 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1124936003351 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1124936003352 threonine efflux system; Provisional; Region: PRK10229 1124936003353 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1124936003354 lysophospholipase L2; Provisional; Region: PRK10749 1124936003355 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124936003356 putative hydrolase; Provisional; Region: PRK10976 1124936003357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936003358 active site 1124936003359 motif I; other site 1124936003360 motif II; other site 1124936003361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936003362 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124936003363 EamA-like transporter family; Region: EamA; pfam00892 1124936003364 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1124936003365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936003366 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1124936003367 putative dimerization interface [polypeptide binding]; other site 1124936003368 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1124936003369 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1124936003370 THF binding site; other site 1124936003371 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1124936003372 substrate binding site [chemical binding]; other site 1124936003373 THF binding site; other site 1124936003374 zinc-binding site [ion binding]; other site 1124936003375 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1124936003376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936003377 FeS/SAM binding site; other site 1124936003378 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124936003379 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1124936003380 uridine phosphorylase; Provisional; Region: PRK11178 1124936003381 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1124936003382 DNA recombination protein RmuC; Provisional; Region: PRK10361 1124936003383 RmuC family; Region: RmuC; pfam02646 1124936003384 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1124936003385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936003386 S-adenosylmethionine binding site [chemical binding]; other site 1124936003387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1124936003388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1124936003389 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1124936003390 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1124936003391 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1124936003392 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1124936003393 sec-independent translocase; Provisional; Region: PRK01770 1124936003394 sec-independent translocase; Provisional; Region: tatB; PRK00404 1124936003395 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1124936003396 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1124936003397 active site 1124936003398 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1124936003399 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1124936003400 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1124936003401 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1124936003402 FMN reductase; Validated; Region: fre; PRK08051 1124936003403 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1124936003404 FAD binding pocket [chemical binding]; other site 1124936003405 FAD binding motif [chemical binding]; other site 1124936003406 phosphate binding motif [ion binding]; other site 1124936003407 beta-alpha-beta structure motif; other site 1124936003408 NAD binding pocket [chemical binding]; other site 1124936003409 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1124936003410 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1124936003411 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124936003412 dimer interface [polypeptide binding]; other site 1124936003413 active site 1124936003414 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1124936003415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124936003416 substrate binding site [chemical binding]; other site 1124936003417 oxyanion hole (OAH) forming residues; other site 1124936003418 trimer interface [polypeptide binding]; other site 1124936003419 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124936003420 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124936003421 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124936003422 proline dipeptidase; Provisional; Region: PRK13607 1124936003423 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1124936003424 active site 1124936003425 hypothetical protein; Provisional; Region: PRK11568 1124936003426 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1124936003427 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1124936003428 potassium transporter; Provisional; Region: PRK10750 1124936003429 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1124936003430 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1124936003431 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1124936003432 Walker A motif; other site 1124936003433 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1124936003434 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1124936003435 GTP binding site; other site 1124936003436 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1124936003437 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1124936003438 serine/threonine protein kinase; Provisional; Region: PRK11768 1124936003439 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1124936003440 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1124936003441 catalytic residues [active] 1124936003442 hinge region; other site 1124936003443 alpha helical domain; other site 1124936003444 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124936003445 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1124936003446 putative acyl-acceptor binding pocket; other site 1124936003447 DNA polymerase I; Provisional; Region: PRK05755 1124936003448 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1124936003449 active site 1124936003450 metal binding site 1 [ion binding]; metal-binding site 1124936003451 putative 5' ssDNA interaction site; other site 1124936003452 metal binding site 3; metal-binding site 1124936003453 metal binding site 2 [ion binding]; metal-binding site 1124936003454 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1124936003455 putative DNA binding site [nucleotide binding]; other site 1124936003456 putative metal binding site [ion binding]; other site 1124936003457 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1124936003458 active site 1124936003459 catalytic site [active] 1124936003460 substrate binding site [chemical binding]; other site 1124936003461 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1124936003462 active site 1124936003463 DNA binding site [nucleotide binding] 1124936003464 catalytic site [active] 1124936003465 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1124936003466 G1 box; other site 1124936003467 GTP/Mg2+ binding site [chemical binding]; other site 1124936003468 Switch I region; other site 1124936003469 G2 box; other site 1124936003470 G3 box; other site 1124936003471 Switch II region; other site 1124936003472 G4 box; other site 1124936003473 G5 box; other site 1124936003474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1124936003475 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1124936003476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936003477 FeS/SAM binding site; other site 1124936003478 HemN C-terminal domain; Region: HemN_C; pfam06969 1124936003479 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1124936003480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936003481 active site 1124936003482 phosphorylation site [posttranslational modification] 1124936003483 intermolecular recognition site; other site 1124936003484 dimerization interface [polypeptide binding]; other site 1124936003485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936003486 Walker A motif; other site 1124936003487 ATP binding site [chemical binding]; other site 1124936003488 Walker B motif; other site 1124936003489 arginine finger; other site 1124936003490 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124936003491 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1124936003492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936003493 putative active site [active] 1124936003494 heme pocket [chemical binding]; other site 1124936003495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936003496 dimer interface [polypeptide binding]; other site 1124936003497 phosphorylation site [posttranslational modification] 1124936003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936003499 ATP binding site [chemical binding]; other site 1124936003500 Mg2+ binding site [ion binding]; other site 1124936003501 G-X-G motif; other site 1124936003502 glutamine synthetase; Provisional; Region: glnA; PRK09469 1124936003503 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1124936003504 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124936003505 GTP-binding protein; Provisional; Region: PRK10218 1124936003506 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1124936003507 G1 box; other site 1124936003508 putative GEF interaction site [polypeptide binding]; other site 1124936003509 GTP/Mg2+ binding site [chemical binding]; other site 1124936003510 Switch I region; other site 1124936003511 G2 box; other site 1124936003512 G3 box; other site 1124936003513 Switch II region; other site 1124936003514 G4 box; other site 1124936003515 G5 box; other site 1124936003516 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1124936003517 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1124936003518 outer membrane porin L; Provisional; Region: ompL; PRK09980 1124936003519 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1124936003520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936003521 putative substrate translocation pore; other site 1124936003522 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1124936003523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936003524 putative substrate translocation pore; other site 1124936003525 alpha-glucosidase; Provisional; Region: PRK10426 1124936003526 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1124936003527 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1124936003528 putative active site [active] 1124936003529 putative catalytic site [active] 1124936003530 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124936003531 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1124936003532 active site 1124936003533 catalytic residues [active] 1124936003534 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1124936003535 dimerization interface [polypeptide binding]; other site 1124936003536 putative active cleft [active] 1124936003537 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1124936003538 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1124936003539 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124936003540 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936003541 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1124936003542 substrate binding site [chemical binding]; other site 1124936003543 ATP binding site [chemical binding]; other site 1124936003544 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936003545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936003546 putative DNA binding site [nucleotide binding]; other site 1124936003547 putative Zn2+ binding site [ion binding]; other site 1124936003548 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936003549 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1124936003550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936003551 motif II; other site 1124936003552 hypothetical protein; Reviewed; Region: PRK01637 1124936003553 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1124936003554 putative active site [active] 1124936003555 dimerization interface [polypeptide binding]; other site 1124936003556 putative tRNAtyr binding site [nucleotide binding]; other site 1124936003557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936003558 Coenzyme A binding pocket [chemical binding]; other site 1124936003559 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1124936003560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936003561 non-specific DNA binding site [nucleotide binding]; other site 1124936003562 salt bridge; other site 1124936003563 sequence-specific DNA binding site [nucleotide binding]; other site 1124936003564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1124936003565 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1124936003566 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1124936003567 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1124936003568 Predicted transcriptional regulator [Transcription]; Region: COG2944 1124936003569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936003570 non-specific DNA binding site [nucleotide binding]; other site 1124936003571 salt bridge; other site 1124936003572 sequence-specific DNA binding site [nucleotide binding]; other site 1124936003573 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1124936003574 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1124936003575 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1124936003576 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1124936003577 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1124936003578 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1124936003579 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936003580 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1124936003581 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1124936003582 molybdopterin cofactor binding site; other site 1124936003583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936003584 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1124936003585 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1124936003586 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1124936003587 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1124936003588 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1124936003589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936003590 non-specific DNA binding site [nucleotide binding]; other site 1124936003591 salt bridge; other site 1124936003592 sequence-specific DNA binding site [nucleotide binding]; other site 1124936003593 Cupin domain; Region: Cupin_2; cl17218 1124936003594 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1124936003595 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1124936003596 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1124936003597 dimer interface [polypeptide binding]; other site 1124936003598 active site 1124936003599 metal binding site [ion binding]; metal-binding site 1124936003600 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1124936003601 intersubunit interface [polypeptide binding]; other site 1124936003602 active site 1124936003603 Zn2+ binding site [ion binding]; other site 1124936003604 L-rhamnose isomerase; Provisional; Region: PRK01076 1124936003605 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1124936003606 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1124936003607 N- and C-terminal domain interface [polypeptide binding]; other site 1124936003608 active site 1124936003609 putative catalytic site [active] 1124936003610 metal binding site [ion binding]; metal-binding site 1124936003611 ATP binding site [chemical binding]; other site 1124936003612 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1124936003613 carbohydrate binding site [chemical binding]; other site 1124936003614 transcriptional activator RhaS; Provisional; Region: PRK13503 1124936003615 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124936003616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936003617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936003618 transcriptional activator RhaR; Provisional; Region: PRK13502 1124936003619 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124936003620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936003621 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 1124936003622 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1124936003623 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1124936003624 DctM-like transporters; Region: DctM; pfam06808 1124936003625 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1124936003626 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1124936003627 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1124936003628 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1124936003629 superoxide dismutase; Provisional; Region: PRK10925 1124936003630 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1124936003631 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1124936003632 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1124936003633 MOSC domain; Region: MOSC; pfam03473 1124936003634 3-alpha domain; Region: 3-alpha; pfam03475 1124936003635 SnoaL-like domain; Region: SnoaL_2; pfam12680 1124936003636 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1124936003637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936003638 dimerization interface [polypeptide binding]; other site 1124936003639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936003640 dimer interface [polypeptide binding]; other site 1124936003641 phosphorylation site [posttranslational modification] 1124936003642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936003643 ATP binding site [chemical binding]; other site 1124936003644 Mg2+ binding site [ion binding]; other site 1124936003645 G-X-G motif; other site 1124936003646 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1124936003647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936003648 active site 1124936003649 intermolecular recognition site; other site 1124936003650 dimerization interface [polypeptide binding]; other site 1124936003651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936003652 DNA binding site [nucleotide binding] 1124936003653 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1124936003654 dimer interface [polypeptide binding]; other site 1124936003655 integrase; Provisional; Region: int; PHA02601 1124936003656 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936003657 active site 1124936003658 DNA binding site [nucleotide binding] 1124936003659 Int/Topo IB signature motif; other site 1124936003660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936003661 non-specific DNA binding site [nucleotide binding]; other site 1124936003662 salt bridge; other site 1124936003663 sequence-specific DNA binding site [nucleotide binding]; other site 1124936003664 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 1124936003665 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1124936003666 DksA-like zinc finger domain containing protein; Region: PHA00080 1124936003667 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1124936003668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936003669 AAA domain; Region: AAA_13; pfam13166 1124936003670 Walker A/P-loop; other site 1124936003671 ATP binding site [chemical binding]; other site 1124936003672 portal vertex protein; Provisional; Region: Q; PHA02536 1124936003673 Phage portal protein; Region: Phage_portal; pfam04860 1124936003674 terminase ATPase subunit; Provisional; Region: P; PHA02535 1124936003675 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1124936003676 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1124936003677 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 1124936003678 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1124936003679 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1124936003680 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1124936003681 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1124936003682 Phage holin family 2; Region: Phage_holin_2; pfam04550 1124936003683 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1124936003684 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936003685 catalytic residue [active] 1124936003686 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1124936003687 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1124936003688 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1124936003689 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1124936003690 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1124936003691 baseplate wedge subunit; Provisional; Region: W; PHA02516 1124936003692 baseplate assembly protein; Provisional; Region: J; PHA02568 1124936003693 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1124936003694 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1124936003695 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1124936003696 SopE GEF domain; Region: SopE_GEF; pfam07487 1124936003697 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1124936003698 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1124936003699 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1124936003700 catalytic residues [active] 1124936003701 catalytic nucleophile [active] 1124936003702 Presynaptic Site I dimer interface [polypeptide binding]; other site 1124936003703 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1124936003704 Synaptic Flat tetramer interface [polypeptide binding]; other site 1124936003705 Synaptic Site I dimer interface [polypeptide binding]; other site 1124936003706 DNA binding site [nucleotide binding] 1124936003707 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1124936003708 DNA-binding interface [nucleotide binding]; DNA binding site 1124936003709 major tail sheath protein; Provisional; Region: FI; PHA02560 1124936003710 major tail tube protein; Provisional; Region: FII; PHA02600 1124936003711 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1124936003712 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1124936003713 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1124936003714 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1124936003715 tail protein; Provisional; Region: D; PHA02561 1124936003716 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1124936003717 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1124936003718 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1124936003719 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1124936003720 potential frameshift: common BLAST hit: gi|409247740|ref|YP_006888435.1| 6-phosphofructokinase 1124936003721 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1124936003722 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936003723 substrate binding pocket [chemical binding]; other site 1124936003724 membrane-bound complex binding site; other site 1124936003725 hinge residues; other site 1124936003726 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1124936003727 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1124936003728 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1124936003729 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936003730 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1124936003731 putative substrate binding site [chemical binding]; other site 1124936003732 putative ATP binding site [chemical binding]; other site 1124936003733 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1124936003734 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1124936003735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936003736 DNA-binding site [nucleotide binding]; DNA binding site 1124936003737 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 1124936003738 UTRA domain; Region: UTRA; pfam07702 1124936003739 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1124936003740 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1124936003741 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1124936003742 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1124936003743 putative N- and C-terminal domain interface [polypeptide binding]; other site 1124936003744 putative active site [active] 1124936003745 putative MgATP binding site [chemical binding]; other site 1124936003746 catalytic site [active] 1124936003747 metal binding site [ion binding]; metal-binding site 1124936003748 putative carbohydrate binding site [chemical binding]; other site 1124936003749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1124936003750 transcriptional regulator LsrR; Provisional; Region: PRK15418 1124936003751 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1124936003752 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1124936003753 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1124936003754 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1124936003755 Walker A/P-loop; other site 1124936003756 ATP binding site [chemical binding]; other site 1124936003757 Q-loop/lid; other site 1124936003758 ABC transporter signature motif; other site 1124936003759 Walker B; other site 1124936003760 D-loop; other site 1124936003761 H-loop/switch region; other site 1124936003762 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1124936003763 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124936003764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1124936003765 TM-ABC transporter signature motif; other site 1124936003766 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124936003767 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1124936003768 TM-ABC transporter signature motif; other site 1124936003769 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1124936003770 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1124936003771 ligand binding site [chemical binding]; other site 1124936003772 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1124936003773 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1124936003774 putative active site; other site 1124936003775 catalytic residue [active] 1124936003776 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1124936003777 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1124936003778 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1124936003779 substrate binding site [chemical binding]; other site 1124936003780 hexamer interface [polypeptide binding]; other site 1124936003781 metal binding site [ion binding]; metal-binding site 1124936003782 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1124936003783 triosephosphate isomerase; Provisional; Region: PRK14567 1124936003784 substrate binding site [chemical binding]; other site 1124936003785 dimer interface [polypeptide binding]; other site 1124936003786 catalytic triad [active] 1124936003787 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1124936003788 Predicted membrane protein [Function unknown]; Region: COG3152 1124936003789 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1124936003790 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1124936003791 FAD binding pocket [chemical binding]; other site 1124936003792 FAD binding motif [chemical binding]; other site 1124936003793 phosphate binding motif [ion binding]; other site 1124936003794 beta-alpha-beta structure motif; other site 1124936003795 NAD binding pocket [chemical binding]; other site 1124936003796 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1124936003797 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1124936003798 putative active site [active] 1124936003799 glycerol kinase; Provisional; Region: glpK; PRK00047 1124936003800 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1124936003801 N- and C-terminal domain interface [polypeptide binding]; other site 1124936003802 active site 1124936003803 MgATP binding site [chemical binding]; other site 1124936003804 catalytic site [active] 1124936003805 metal binding site [ion binding]; metal-binding site 1124936003806 glycerol binding site [chemical binding]; other site 1124936003807 homotetramer interface [polypeptide binding]; other site 1124936003808 homodimer interface [polypeptide binding]; other site 1124936003809 FBP binding site [chemical binding]; other site 1124936003810 protein IIAGlc interface [polypeptide binding]; other site 1124936003811 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1124936003812 amphipathic channel; other site 1124936003813 Asn-Pro-Ala signature motifs; other site 1124936003814 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1124936003815 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1124936003816 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1124936003817 UbiA prenyltransferase family; Region: UbiA; pfam01040 1124936003818 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1124936003819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936003820 Walker A motif; other site 1124936003821 ATP binding site [chemical binding]; other site 1124936003822 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1124936003823 Walker B motif; other site 1124936003824 arginine finger; other site 1124936003825 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124936003826 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1124936003827 active site 1124936003828 HslU subunit interaction site [polypeptide binding]; other site 1124936003829 essential cell division protein FtsN; Provisional; Region: PRK10927 1124936003830 cell division protein FtsN; Provisional; Region: PRK12757 1124936003831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936003832 DNA binding site [nucleotide binding] 1124936003833 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1124936003834 domain linker motif; other site 1124936003835 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1124936003836 dimerization interface [polypeptide binding]; other site 1124936003837 ligand binding site [chemical binding]; other site 1124936003838 primosome assembly protein PriA; Validated; Region: PRK05580 1124936003839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936003840 ATP binding site [chemical binding]; other site 1124936003841 putative Mg++ binding site [ion binding]; other site 1124936003842 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1124936003843 ATP-binding site [chemical binding]; other site 1124936003844 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1124936003845 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 1124936003846 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1124936003847 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1124936003848 dimerization interface [polypeptide binding]; other site 1124936003849 DNA binding site [nucleotide binding] 1124936003850 corepressor binding sites; other site 1124936003851 cystathionine gamma-synthase; Provisional; Region: PRK08045 1124936003852 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1124936003853 homodimer interface [polypeptide binding]; other site 1124936003854 substrate-cofactor binding pocket; other site 1124936003855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936003856 catalytic residue [active] 1124936003857 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1124936003858 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1124936003859 putative catalytic residues [active] 1124936003860 putative nucleotide binding site [chemical binding]; other site 1124936003861 putative aspartate binding site [chemical binding]; other site 1124936003862 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1124936003863 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1124936003864 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1124936003865 mechanosensitive channel MscS; Provisional; Region: PRK10334 1124936003866 Conserved TM helix; Region: TM_helix; pfam05552 1124936003867 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936003868 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1124936003869 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1124936003870 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1124936003871 active site 1124936003872 metal binding site [ion binding]; metal-binding site 1124936003873 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1124936003874 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1124936003875 FAD binding site [chemical binding]; other site 1124936003876 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1124936003877 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1124936003878 heme binding site [chemical binding]; other site 1124936003879 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1124936003880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1124936003881 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1124936003882 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1124936003883 dimer interface [polypeptide binding]; other site 1124936003884 active site 1124936003885 metal binding site [ion binding]; metal-binding site 1124936003886 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1124936003887 active site 1124936003888 intersubunit interactions; other site 1124936003889 catalytic residue [active] 1124936003890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936003891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936003892 hypothetical protein; Provisional; Region: PRK10649 1124936003893 Sulfatase; Region: Sulfatase; pfam00884 1124936003894 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1124936003895 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1124936003896 acetylornithine deacetylase; Provisional; Region: PRK05111 1124936003897 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1124936003898 metal binding site [ion binding]; metal-binding site 1124936003899 putative dimer interface [polypeptide binding]; other site 1124936003900 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1124936003901 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1124936003902 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1124936003903 nucleotide binding site [chemical binding]; other site 1124936003904 N-acetyl-L-glutamate binding site [chemical binding]; other site 1124936003905 argininosuccinate lyase; Provisional; Region: PRK04833 1124936003906 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1124936003907 active sites [active] 1124936003908 tetramer interface [polypeptide binding]; other site 1124936003909 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1124936003910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936003911 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1124936003912 dimerization interface [polypeptide binding]; other site 1124936003913 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1124936003914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936003915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124936003916 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1124936003917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936003918 hypothetical protein; Provisional; Region: PRK11056 1124936003919 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1124936003920 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1124936003921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936003922 S-adenosylmethionine binding site [chemical binding]; other site 1124936003923 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1124936003924 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936003925 N-terminal plug; other site 1124936003926 ligand-binding site [chemical binding]; other site 1124936003927 glutamate racemase; Provisional; Region: PRK00865 1124936003928 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1124936003929 FAD binding domain; Region: FAD_binding_4; pfam01565 1124936003930 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1124936003931 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1124936003932 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1124936003933 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1124936003934 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1124936003935 pantothenate kinase; Provisional; Region: PRK05439 1124936003936 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1124936003937 ATP-binding site [chemical binding]; other site 1124936003938 CoA-binding site [chemical binding]; other site 1124936003939 Mg2+-binding site [ion binding]; other site 1124936003940 elongation factor Tu; Reviewed; Region: PRK00049 1124936003941 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1124936003942 G1 box; other site 1124936003943 GEF interaction site [polypeptide binding]; other site 1124936003944 GTP/Mg2+ binding site [chemical binding]; other site 1124936003945 Switch I region; other site 1124936003946 G2 box; other site 1124936003947 G3 box; other site 1124936003948 Switch II region; other site 1124936003949 G4 box; other site 1124936003950 G5 box; other site 1124936003951 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1124936003952 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1124936003953 Antibiotic Binding Site [chemical binding]; other site 1124936003954 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1124936003955 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1124936003956 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1124936003957 putative homodimer interface [polypeptide binding]; other site 1124936003958 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1124936003959 heterodimer interface [polypeptide binding]; other site 1124936003960 homodimer interface [polypeptide binding]; other site 1124936003961 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1124936003962 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1124936003963 23S rRNA interface [nucleotide binding]; other site 1124936003964 L7/L12 interface [polypeptide binding]; other site 1124936003965 putative thiostrepton binding site; other site 1124936003966 L25 interface [polypeptide binding]; other site 1124936003967 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1124936003968 mRNA/rRNA interface [nucleotide binding]; other site 1124936003969 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1124936003970 23S rRNA interface [nucleotide binding]; other site 1124936003971 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1124936003972 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1124936003973 core dimer interface [polypeptide binding]; other site 1124936003974 peripheral dimer interface [polypeptide binding]; other site 1124936003975 L10 interface [polypeptide binding]; other site 1124936003976 L11 interface [polypeptide binding]; other site 1124936003977 putative EF-Tu interaction site [polypeptide binding]; other site 1124936003978 putative EF-G interaction site [polypeptide binding]; other site 1124936003979 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1124936003980 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1124936003981 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1124936003982 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1124936003983 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1124936003984 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1124936003985 RPB3 interaction site [polypeptide binding]; other site 1124936003986 RPB1 interaction site [polypeptide binding]; other site 1124936003987 RPB11 interaction site [polypeptide binding]; other site 1124936003988 RPB10 interaction site [polypeptide binding]; other site 1124936003989 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1124936003990 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1124936003991 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1124936003992 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1124936003993 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1124936003994 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1124936003995 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1124936003996 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1124936003997 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1124936003998 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1124936003999 DNA binding site [nucleotide binding] 1124936004000 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1124936004001 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1124936004002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936004003 FeS/SAM binding site; other site 1124936004004 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1124936004005 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1124936004006 ThiS interaction site; other site 1124936004007 putative active site [active] 1124936004008 tetramer interface [polypeptide binding]; other site 1124936004009 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1124936004010 thiS-thiF/thiG interaction site; other site 1124936004011 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1124936004012 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1124936004013 ATP binding site [chemical binding]; other site 1124936004014 substrate interface [chemical binding]; other site 1124936004015 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1124936004016 thiamine phosphate binding site [chemical binding]; other site 1124936004017 active site 1124936004018 pyrophosphate binding site [ion binding]; other site 1124936004019 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1124936004020 ThiC-associated domain; Region: ThiC-associated; pfam13667 1124936004021 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1124936004022 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1124936004023 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1124936004024 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1124936004025 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1124936004026 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1124936004027 putative NADH binding site [chemical binding]; other site 1124936004028 putative active site [active] 1124936004029 nudix motif; other site 1124936004030 putative metal binding site [ion binding]; other site 1124936004031 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1124936004032 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1124936004033 substrate binding site [chemical binding]; other site 1124936004034 active site 1124936004035 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1124936004036 Active_site [active] 1124936004037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1124936004038 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124936004039 IHF dimer interface [polypeptide binding]; other site 1124936004040 IHF - DNA interface [nucleotide binding]; other site 1124936004041 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1124936004042 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1124936004043 dimer interface [polypeptide binding]; other site 1124936004044 sensor protein ZraS; Provisional; Region: PRK10364 1124936004045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936004046 dimer interface [polypeptide binding]; other site 1124936004047 phosphorylation site [posttranslational modification] 1124936004048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936004049 ATP binding site [chemical binding]; other site 1124936004050 Mg2+ binding site [ion binding]; other site 1124936004051 G-X-G motif; other site 1124936004052 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1124936004053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936004054 active site 1124936004055 phosphorylation site [posttranslational modification] 1124936004056 intermolecular recognition site; other site 1124936004057 dimerization interface [polypeptide binding]; other site 1124936004058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936004059 Walker A motif; other site 1124936004060 ATP binding site [chemical binding]; other site 1124936004061 Walker B motif; other site 1124936004062 arginine finger; other site 1124936004063 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124936004064 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1124936004065 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1124936004066 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1124936004067 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1124936004068 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1124936004069 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1124936004070 purine monophosphate binding site [chemical binding]; other site 1124936004071 dimer interface [polypeptide binding]; other site 1124936004072 putative catalytic residues [active] 1124936004073 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1124936004074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124936004075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936004076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124936004077 Coenzyme A binding pocket [chemical binding]; other site 1124936004078 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1124936004079 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1124936004080 proposed active site lysine [active] 1124936004081 conserved cys residue [active] 1124936004082 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1124936004083 malate synthase A; Region: malate_syn_A; TIGR01344 1124936004084 active site 1124936004085 isocitrate lyase; Provisional; Region: PRK15063 1124936004086 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124936004087 tetramer interface [polypeptide binding]; other site 1124936004088 active site 1124936004089 Mg2+/Mn2+ binding site [ion binding]; other site 1124936004090 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1124936004091 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1124936004092 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1124936004093 transcriptional repressor IclR; Provisional; Region: PRK11569 1124936004094 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124936004095 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124936004096 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1124936004097 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1124936004098 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1124936004099 substrate binding pocket [chemical binding]; other site 1124936004100 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1124936004101 B12 binding site [chemical binding]; other site 1124936004102 cobalt ligand [ion binding]; other site 1124936004103 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1124936004104 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1124936004105 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1124936004106 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1124936004107 active site pocket [active] 1124936004108 oxyanion hole [active] 1124936004109 catalytic triad [active] 1124936004110 active site nucleophile [active] 1124936004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1124936004112 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1124936004113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936004114 RNA binding surface [nucleotide binding]; other site 1124936004115 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1124936004116 probable active site [active] 1124936004117 hypothetical protein; Provisional; Region: PRK10515 1124936004118 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1124936004119 Sodium Bile acid symporter family; Region: SBF; pfam01758 1124936004120 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1124936004121 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1124936004122 trimer interface [polypeptide binding]; other site 1124936004123 active site 1124936004124 substrate binding site [chemical binding]; other site 1124936004125 CoA binding site [chemical binding]; other site 1124936004126 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1124936004127 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1124936004128 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1124936004129 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1124936004130 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1124936004131 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 1124936004132 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1124936004133 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1124936004134 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1124936004135 Ligand binding site; other site 1124936004136 Putative Catalytic site; other site 1124936004137 DXD motif; other site 1124936004138 Predicted membrane protein [Function unknown]; Region: COG2246 1124936004139 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1124936004140 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1124936004141 Phage protein D [General function prediction only]; Region: COG3500 1124936004142 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1124936004143 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1124936004144 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1124936004145 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1124936004146 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1124936004147 Phage tail tube protein FII [General function prediction only]; Region: COG3498 1124936004148 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1124936004149 Gp37 protein; Region: Gp37; pfam09646 1124936004150 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1124936004151 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936004152 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936004153 catalytic residue [active] 1124936004154 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1124936004155 Mor transcription activator family; Region: Mor; pfam08765 1124936004156 aspartate kinase III; Validated; Region: PRK09084 1124936004157 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1124936004158 nucleotide binding site [chemical binding]; other site 1124936004159 substrate binding site [chemical binding]; other site 1124936004160 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1124936004161 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1124936004162 dimer interface [polypeptide binding]; other site 1124936004163 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1124936004164 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1124936004165 active site 1124936004166 dimer interface [polypeptide binding]; other site 1124936004167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1124936004168 dimer interface [polypeptide binding]; other site 1124936004169 active site 1124936004170 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 1124936004171 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1124936004172 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1124936004173 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1124936004174 Predicted membrane protein [Function unknown]; Region: COG3223 1124936004175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1124936004176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936004177 dimer interface [polypeptide binding]; other site 1124936004178 conserved gate region; other site 1124936004179 putative PBP binding loops; other site 1124936004180 ABC-ATPase subunit interface; other site 1124936004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936004182 dimer interface [polypeptide binding]; other site 1124936004183 conserved gate region; other site 1124936004184 putative PBP binding loops; other site 1124936004185 ABC-ATPase subunit interface; other site 1124936004186 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1124936004187 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1124936004188 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1124936004189 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1124936004190 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1124936004191 Walker A/P-loop; other site 1124936004192 ATP binding site [chemical binding]; other site 1124936004193 Q-loop/lid; other site 1124936004194 ABC transporter signature motif; other site 1124936004195 Walker B; other site 1124936004196 D-loop; other site 1124936004197 H-loop/switch region; other site 1124936004198 TOBE domain; Region: TOBE_2; pfam08402 1124936004199 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1124936004200 trimer interface; other site 1124936004201 sugar binding site [chemical binding]; other site 1124936004202 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1124936004203 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1124936004204 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1124936004205 UbiA prenyltransferase family; Region: UbiA; pfam01040 1124936004206 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1124936004207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1124936004208 putative acyl-acceptor binding pocket; other site 1124936004209 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1124936004210 LexA repressor; Validated; Region: PRK00215 1124936004211 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1124936004212 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124936004213 Catalytic site [active] 1124936004214 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1124936004215 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1124936004216 hypothetical protein; Provisional; Region: PRK10428 1124936004217 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1124936004218 metal binding site 2 [ion binding]; metal-binding site 1124936004219 putative DNA binding helix; other site 1124936004220 metal binding site 1 [ion binding]; metal-binding site 1124936004221 dimer interface [polypeptide binding]; other site 1124936004222 structural Zn2+ binding site [ion binding]; other site 1124936004223 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1124936004224 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1124936004225 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1124936004226 FMN binding site [chemical binding]; other site 1124936004227 active site 1124936004228 catalytic residues [active] 1124936004229 substrate binding site [chemical binding]; other site 1124936004230 phage shock protein G; Reviewed; Region: pspG; PRK09459 1124936004231 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1124936004232 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1124936004233 NADP binding site [chemical binding]; other site 1124936004234 dimer interface [polypeptide binding]; other site 1124936004235 replicative DNA helicase; Provisional; Region: PRK08006 1124936004236 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1124936004237 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1124936004238 Walker A motif; other site 1124936004239 ATP binding site [chemical binding]; other site 1124936004240 Walker B motif; other site 1124936004241 DNA binding loops [nucleotide binding] 1124936004242 alanine racemase; Reviewed; Region: alr; PRK00053 1124936004243 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1124936004244 active site 1124936004245 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936004246 substrate binding site [chemical binding]; other site 1124936004247 catalytic residues [active] 1124936004248 dimer interface [polypeptide binding]; other site 1124936004249 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1124936004250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936004251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936004252 homodimer interface [polypeptide binding]; other site 1124936004253 catalytic residue [active] 1124936004254 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1124936004255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936004256 active site 1124936004257 motif I; other site 1124936004258 motif II; other site 1124936004259 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1124936004260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1124936004261 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1124936004262 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1124936004263 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1124936004264 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1124936004265 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1124936004266 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1124936004267 dimer interface [polypeptide binding]; other site 1124936004268 ssDNA binding site [nucleotide binding]; other site 1124936004269 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124936004270 hypothetical protein; Validated; Region: PRK09039 1124936004271 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1124936004272 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124936004273 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1124936004274 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936004275 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936004276 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936004277 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004278 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004279 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004280 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004281 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004282 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004283 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936004284 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004285 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004286 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004287 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004288 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936004289 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004290 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004291 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936004292 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004293 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004294 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004295 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004296 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936004297 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004298 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004299 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004300 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004301 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004302 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004303 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124936004304 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004305 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004306 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004307 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004308 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004309 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004310 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936004311 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004312 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 1124936004313 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004314 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004315 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936004316 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1124936004317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936004318 Walker A/P-loop; other site 1124936004319 ATP binding site [chemical binding]; other site 1124936004320 Q-loop/lid; other site 1124936004321 ABC transporter signature motif; other site 1124936004322 Walker B; other site 1124936004323 D-loop; other site 1124936004324 H-loop/switch region; other site 1124936004325 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1124936004326 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124936004327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936004328 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1124936004329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936004330 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1124936004331 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1124936004332 DNA binding residues [nucleotide binding] 1124936004333 dimer interface [polypeptide binding]; other site 1124936004334 [2Fe-2S] cluster binding site [ion binding]; other site 1124936004335 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124936004336 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1124936004337 putative C-terminal domain interface [polypeptide binding]; other site 1124936004338 putative GSH binding site (G-site) [chemical binding]; other site 1124936004339 putative dimer interface [polypeptide binding]; other site 1124936004340 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1124936004341 putative N-terminal domain interface [polypeptide binding]; other site 1124936004342 putative dimer interface [polypeptide binding]; other site 1124936004343 putative substrate binding pocket (H-site) [chemical binding]; other site 1124936004344 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1124936004345 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1124936004346 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1124936004347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936004348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936004349 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1124936004350 putative dimerization interface [polypeptide binding]; other site 1124936004351 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1124936004352 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1124936004353 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1124936004354 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1124936004355 Na binding site [ion binding]; other site 1124936004356 Predicted membrane protein [Function unknown]; Region: COG3162 1124936004357 acetyl-CoA synthetase; Provisional; Region: PRK00174 1124936004358 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1124936004359 active site 1124936004360 CoA binding site [chemical binding]; other site 1124936004361 acyl-activating enzyme (AAE) consensus motif; other site 1124936004362 AMP binding site [chemical binding]; other site 1124936004363 acetate binding site [chemical binding]; other site 1124936004364 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1124936004365 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1124936004366 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1124936004367 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1124936004368 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1124936004369 heme lyase subunit NrfE; Provisional; Region: PRK10369 1124936004370 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1124936004371 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1124936004372 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1124936004373 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124936004374 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936004375 Sel1-like repeats; Region: SEL1; smart00671 1124936004376 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936004377 molybdopterin cofactor binding site; other site 1124936004378 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1124936004379 molybdopterin cofactor binding site; other site 1124936004380 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936004381 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1124936004382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936004383 Coenzyme A binding pocket [chemical binding]; other site 1124936004384 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1124936004385 dimer interface [polypeptide binding]; other site 1124936004386 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124936004387 hypothetical protein; Provisional; Region: PRK10220 1124936004388 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1124936004389 PhnA protein; Region: PhnA; pfam03831 1124936004390 proline/glycine betaine transporter; Provisional; Region: PRK10642 1124936004391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936004392 putative substrate translocation pore; other site 1124936004393 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1124936004394 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1124936004395 HAMP domain; Region: HAMP; pfam00672 1124936004396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936004397 dimer interface [polypeptide binding]; other site 1124936004398 phosphorylation site [posttranslational modification] 1124936004399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936004400 ATP binding site [chemical binding]; other site 1124936004401 Mg2+ binding site [ion binding]; other site 1124936004402 G-X-G motif; other site 1124936004403 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1124936004404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936004405 active site 1124936004406 phosphorylation site [posttranslational modification] 1124936004407 intermolecular recognition site; other site 1124936004408 dimerization interface [polypeptide binding]; other site 1124936004409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936004410 DNA binding site [nucleotide binding] 1124936004411 putative metal dependent hydrolase; Provisional; Region: PRK11598 1124936004412 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1124936004413 Sulfatase; Region: Sulfatase; pfam00884 1124936004414 arginine:agmatin antiporter; Provisional; Region: PRK10644 1124936004415 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1124936004416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936004417 arginine decarboxylase; Provisional; Region: PRK15029 1124936004418 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1124936004419 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1124936004420 homodimer interface [polypeptide binding]; other site 1124936004421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936004422 catalytic residue [active] 1124936004423 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1124936004424 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1124936004425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936004426 alpha-galactosidase; Provisional; Region: PRK15076 1124936004427 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1124936004428 NAD binding site [chemical binding]; other site 1124936004429 sugar binding site [chemical binding]; other site 1124936004430 divalent metal binding site [ion binding]; other site 1124936004431 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124936004432 dimer interface [polypeptide binding]; other site 1124936004433 melibiose:sodium symporter; Provisional; Region: PRK10429 1124936004434 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1124936004435 fumarate hydratase; Provisional; Region: PRK15389 1124936004436 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1124936004437 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1124936004438 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1124936004439 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1124936004440 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1124936004441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936004442 active site 1124936004443 phosphorylation site [posttranslational modification] 1124936004444 intermolecular recognition site; other site 1124936004445 dimerization interface [polypeptide binding]; other site 1124936004446 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1124936004447 PAS domain; Region: PAS; smart00091 1124936004448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936004449 ATP binding site [chemical binding]; other site 1124936004450 Mg2+ binding site [ion binding]; other site 1124936004451 G-X-G motif; other site 1124936004452 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1124936004453 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1124936004454 putative [Fe4-S4] binding site [ion binding]; other site 1124936004455 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936004456 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1124936004457 putative molybdopterin cofactor binding site; other site 1124936004458 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1124936004459 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1124936004460 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1124936004461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1124936004462 SdiA-regulated; Region: SdiA-regulated; cd09971 1124936004463 putative active site [active] 1124936004464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124936004465 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936004466 DNA binding residues [nucleotide binding] 1124936004467 dimerization interface [polypeptide binding]; other site 1124936004468 AraC family transcriptional regulator; Provisional; Region: PRK15186 1124936004469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936004470 Integrase core domain; Region: rve; pfam00665 1124936004471 Integrase core domain; Region: rve_2; pfam13333 1124936004472 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1124936004473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1124936004474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1124936004475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1124936004476 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124936004477 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1124936004478 active site 1124936004479 putative transcriptional regulator; Provisional; Region: PRK11640 1124936004480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936004481 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1124936004482 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1124936004483 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1124936004484 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1124936004485 DsbD alpha interface [polypeptide binding]; other site 1124936004486 catalytic residues [active] 1124936004487 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1124936004488 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1124936004489 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1124936004490 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1124936004491 Aspartase; Region: Aspartase; cd01357 1124936004492 active sites [active] 1124936004493 tetramer interface [polypeptide binding]; other site 1124936004494 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1124936004495 putative transporter; Provisional; Region: PRK11021 1124936004496 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1124936004497 oligomerisation interface [polypeptide binding]; other site 1124936004498 mobile loop; other site 1124936004499 roof hairpin; other site 1124936004500 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1124936004501 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1124936004502 ring oligomerisation interface [polypeptide binding]; other site 1124936004503 ATP/Mg binding site [chemical binding]; other site 1124936004504 stacking interactions; other site 1124936004505 hinge regions; other site 1124936004506 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1124936004507 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1124936004508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936004509 FeS/SAM binding site; other site 1124936004510 elongation factor P; Validated; Region: PRK00529 1124936004511 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1124936004512 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1124936004513 RNA binding site [nucleotide binding]; other site 1124936004514 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1124936004515 RNA binding site [nucleotide binding]; other site 1124936004516 Predicted small secreted protein [Function unknown]; Region: COG5510 1124936004517 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1124936004518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124936004519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936004520 DNA binding residues [nucleotide binding] 1124936004521 dimerization interface [polypeptide binding]; other site 1124936004522 multidrug efflux system protein; Provisional; Region: PRK11431 1124936004523 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1124936004524 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1124936004525 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1124936004526 Iron-sulfur protein interface; other site 1124936004527 proximal quinone binding site [chemical binding]; other site 1124936004528 C-subunit interface; other site 1124936004529 distal quinone binding site; other site 1124936004530 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1124936004531 D-subunit interface [polypeptide binding]; other site 1124936004532 Iron-sulfur protein interface; other site 1124936004533 proximal quinone binding site [chemical binding]; other site 1124936004534 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1124936004535 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1124936004536 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1124936004537 L-aspartate oxidase; Provisional; Region: PRK06175 1124936004538 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1124936004539 poxB regulator PoxA; Provisional; Region: PRK09350 1124936004540 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1124936004541 motif 1; other site 1124936004542 dimer interface [polypeptide binding]; other site 1124936004543 active site 1124936004544 motif 2; other site 1124936004545 motif 3; other site 1124936004546 inner membrane transporter YjeM; Provisional; Region: PRK15238 1124936004547 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1124936004548 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1124936004549 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936004550 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1124936004551 GTPase RsgA; Reviewed; Region: PRK12288 1124936004552 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1124936004553 RNA binding site [nucleotide binding]; other site 1124936004554 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1124936004555 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1124936004556 GTP/Mg2+ binding site [chemical binding]; other site 1124936004557 G4 box; other site 1124936004558 G5 box; other site 1124936004559 G1 box; other site 1124936004560 Switch I region; other site 1124936004561 G2 box; other site 1124936004562 G3 box; other site 1124936004563 Switch II region; other site 1124936004564 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1124936004565 catalytic site [active] 1124936004566 putative active site [active] 1124936004567 putative substrate binding site [chemical binding]; other site 1124936004568 dimer interface [polypeptide binding]; other site 1124936004569 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1124936004570 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936004571 substrate binding pocket [chemical binding]; other site 1124936004572 membrane-bound complex binding site; other site 1124936004573 hinge residues; other site 1124936004574 epoxyqueuosine reductase; Region: TIGR00276 1124936004575 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1124936004576 putative carbohydrate kinase; Provisional; Region: PRK10565 1124936004577 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1124936004578 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1124936004579 putative substrate binding site [chemical binding]; other site 1124936004580 putative ATP binding site [chemical binding]; other site 1124936004581 ADP-binding protein; Provisional; Region: PRK10646 1124936004582 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1124936004583 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1124936004584 active site 1124936004585 metal binding site [ion binding]; metal-binding site 1124936004586 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1124936004587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936004588 ATP binding site [chemical binding]; other site 1124936004589 Mg2+ binding site [ion binding]; other site 1124936004590 G-X-G motif; other site 1124936004591 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1124936004592 ATP binding site [chemical binding]; other site 1124936004593 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1124936004594 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1124936004595 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1124936004596 bacterial Hfq-like; Region: Hfq; cd01716 1124936004597 hexamer interface [polypeptide binding]; other site 1124936004598 Sm1 motif; other site 1124936004599 RNA binding site [nucleotide binding]; other site 1124936004600 Sm2 motif; other site 1124936004601 GTPase HflX; Provisional; Region: PRK11058 1124936004602 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1124936004603 HflX GTPase family; Region: HflX; cd01878 1124936004604 G1 box; other site 1124936004605 GTP/Mg2+ binding site [chemical binding]; other site 1124936004606 Switch I region; other site 1124936004607 G2 box; other site 1124936004608 G3 box; other site 1124936004609 Switch II region; other site 1124936004610 G4 box; other site 1124936004611 G5 box; other site 1124936004612 FtsH protease regulator HflK; Provisional; Region: PRK10930 1124936004613 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1124936004614 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1124936004615 FtsH protease regulator HflC; Provisional; Region: PRK11029 1124936004616 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1124936004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1124936004618 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1124936004619 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1124936004620 GDP-binding site [chemical binding]; other site 1124936004621 ACT binding site; other site 1124936004622 IMP binding site; other site 1124936004623 Predicted transcriptional regulator [Transcription]; Region: COG1959 1124936004624 transcriptional repressor NsrR; Provisional; Region: PRK11014 1124936004625 exoribonuclease R; Provisional; Region: PRK11642 1124936004626 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1124936004627 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1124936004628 RNB domain; Region: RNB; pfam00773 1124936004629 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1124936004630 RNA binding site [nucleotide binding]; other site 1124936004631 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1124936004632 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1124936004633 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1124936004634 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1124936004635 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1124936004636 Ion channel; Region: Ion_trans_2; pfam07885 1124936004637 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1124936004638 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1124936004639 Predicted membrane protein [Function unknown]; Region: COG3766 1124936004640 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1124936004641 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1124936004642 Predicted integral membrane protein [Function unknown]; Region: COG5463 1124936004643 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1124936004644 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1124936004645 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1124936004646 FAD binding site [chemical binding]; other site 1124936004647 substrate binding site [chemical binding]; other site 1124936004648 catalytic residues [active] 1124936004649 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936004650 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1124936004651 esterase; Provisional; Region: PRK10566 1124936004652 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124936004653 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124936004654 transcriptional repressor UlaR; Provisional; Region: PRK13509 1124936004655 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124936004656 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936004657 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1124936004658 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1124936004659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1124936004660 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1124936004661 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1124936004662 active site 1124936004663 P-loop; other site 1124936004664 phosphorylation site [posttranslational modification] 1124936004665 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936004666 active site 1124936004667 phosphorylation site [posttranslational modification] 1124936004668 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1124936004669 active site 1124936004670 dimer interface [polypeptide binding]; other site 1124936004671 magnesium binding site [ion binding]; other site 1124936004672 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1124936004673 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1124936004674 AP (apurinic/apyrimidinic) site pocket; other site 1124936004675 DNA interaction; other site 1124936004676 Metal-binding active site; metal-binding site 1124936004677 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1124936004678 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1124936004679 intersubunit interface [polypeptide binding]; other site 1124936004680 active site 1124936004681 Zn2+ binding site [ion binding]; other site 1124936004682 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936004683 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1124936004684 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1124936004685 dimer interface [polypeptide binding]; other site 1124936004686 ssDNA binding site [nucleotide binding]; other site 1124936004687 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124936004688 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1124936004689 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1124936004690 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1124936004691 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1124936004692 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124936004693 EamA-like transporter family; Region: EamA; pfam00892 1124936004694 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1124936004695 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1124936004696 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1124936004697 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1124936004698 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124936004699 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1124936004700 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1124936004701 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1124936004702 Hemerythrin-like domain; Region: Hr-like; cd12108 1124936004703 Fe binding site [ion binding]; other site 1124936004704 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124936004705 EamA-like transporter family; Region: EamA; pfam00892 1124936004706 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1124936004707 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1124936004708 NADP binding site [chemical binding]; other site 1124936004709 Predicted transcriptional regulators [Transcription]; Region: COG1733 1124936004710 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1124936004711 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1124936004712 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1124936004713 active site 1124936004714 metal binding site [ion binding]; metal-binding site 1124936004715 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1124936004716 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1124936004717 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1124936004718 active site 1124936004719 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1124936004720 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1124936004721 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1124936004722 Domain of unknown function DUF21; Region: DUF21; pfam01595 1124936004723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124936004724 Transporter associated domain; Region: CorC_HlyC; smart01091 1124936004725 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1124936004726 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1124936004727 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124936004728 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124936004729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1124936004730 Family of unknown function (DUF490); Region: DUF490; pfam04357 1124936004731 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1124936004732 putative active site pocket [active] 1124936004733 dimerization interface [polypeptide binding]; other site 1124936004734 putative catalytic residue [active] 1124936004735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936004736 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936004737 putative substrate translocation pore; other site 1124936004738 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1124936004739 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1124936004740 active site 1124936004741 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1124936004742 dimer interface [polypeptide binding]; other site 1124936004743 substrate binding site [chemical binding]; other site 1124936004744 metal binding sites [ion binding]; metal-binding site 1124936004745 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1124936004746 AMP binding site [chemical binding]; other site 1124936004747 metal binding site [ion binding]; metal-binding site 1124936004748 active site 1124936004749 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1124936004750 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124936004751 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124936004752 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124936004753 hypothetical protein; Provisional; Region: PRK05255 1124936004754 peptidase PmbA; Provisional; Region: PRK11040 1124936004755 cytochrome b562; Provisional; Region: PRK15058 1124936004756 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1124936004757 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1124936004758 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1124936004759 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1124936004760 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1124936004761 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1124936004762 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1124936004763 active site 1124936004764 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1124936004765 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1124936004766 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1124936004767 HTH domain; Region: HTH_11; pfam08279 1124936004768 Mga helix-turn-helix domain; Region: Mga; pfam05043 1124936004769 PRD domain; Region: PRD; pfam00874 1124936004770 PRD domain; Region: PRD; pfam00874 1124936004771 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1124936004772 active site 1124936004773 P-loop; other site 1124936004774 phosphorylation site [posttranslational modification] 1124936004775 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936004776 active site 1124936004777 phosphorylation site [posttranslational modification] 1124936004778 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1124936004779 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1124936004780 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1124936004781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936004782 FeS/SAM binding site; other site 1124936004783 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1124936004784 ATP cone domain; Region: ATP-cone; pfam03477 1124936004785 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1124936004786 effector binding site; other site 1124936004787 active site 1124936004788 Zn binding site [ion binding]; other site 1124936004789 glycine loop; other site 1124936004790 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1124936004791 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1124936004792 Ca binding site [ion binding]; other site 1124936004793 active site 1124936004794 catalytic site [active] 1124936004795 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1124936004796 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1124936004797 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124936004798 active site turn [active] 1124936004799 phosphorylation site [posttranslational modification] 1124936004800 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124936004801 trehalose repressor; Provisional; Region: treR; PRK09492 1124936004802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936004803 DNA binding site [nucleotide binding] 1124936004804 domain linker motif; other site 1124936004805 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1124936004806 dimerization interface [polypeptide binding]; other site 1124936004807 ligand binding site [chemical binding]; other site 1124936004808 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1124936004809 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1124936004810 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124936004811 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1124936004812 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1124936004813 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1124936004814 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1124936004815 Transposase; Region: HTH_Tnp_1; cl17663 1124936004816 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1124936004817 homotrimer interaction site [polypeptide binding]; other site 1124936004818 putative active site [active] 1124936004819 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1124936004820 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1124936004821 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1124936004822 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1124936004823 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1124936004824 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1124936004825 pyrBI operon leader peptide; Provisional; Region: PRK10224 1124936004826 Arginine repressor [Transcription]; Region: ArgR; COG1438 1124936004827 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1124936004828 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1124936004829 Predicted membrane protein [Function unknown]; Region: COG1288 1124936004830 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1124936004831 ornithine carbamoyltransferase; Validated; Region: PRK02102 1124936004832 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1124936004833 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1124936004834 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1124936004835 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1124936004836 putative substrate binding site [chemical binding]; other site 1124936004837 nucleotide binding site [chemical binding]; other site 1124936004838 nucleotide binding site [chemical binding]; other site 1124936004839 homodimer interface [polypeptide binding]; other site 1124936004840 arginine deiminase; Provisional; Region: PRK01388 1124936004841 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1124936004842 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1124936004843 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1124936004844 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1124936004845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1124936004846 RNase E inhibitor protein; Provisional; Region: PRK11191 1124936004847 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1124936004848 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1124936004849 active site 1124936004850 dinuclear metal binding site [ion binding]; other site 1124936004851 dimerization interface [polypeptide binding]; other site 1124936004852 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1124936004853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124936004854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936004855 Coenzyme A binding pocket [chemical binding]; other site 1124936004856 Predicted membrane protein [Function unknown]; Region: COG4269 1124936004857 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1124936004858 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1124936004859 HIGH motif; other site 1124936004860 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1124936004861 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1124936004862 active site 1124936004863 KMSKS motif; other site 1124936004864 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1124936004865 tRNA binding surface [nucleotide binding]; other site 1124936004866 anticodon binding site; other site 1124936004867 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1124936004868 DNA polymerase III subunit chi; Validated; Region: PRK05728 1124936004869 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1124936004870 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1124936004871 interface (dimer of trimers) [polypeptide binding]; other site 1124936004872 Substrate-binding/catalytic site; other site 1124936004873 Zn-binding sites [ion binding]; other site 1124936004874 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1124936004875 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1124936004876 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1124936004877 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1124936004878 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1124936004879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936004880 DNA binding site [nucleotide binding] 1124936004881 domain linker motif; other site 1124936004882 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1124936004883 putative dimerization interface [polypeptide binding]; other site 1124936004884 putative ligand binding site [chemical binding]; other site 1124936004885 gluconate transporter; Region: gntP; TIGR00791 1124936004886 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124936004887 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1124936004888 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1124936004889 NADP binding site [chemical binding]; other site 1124936004890 homodimer interface [polypeptide binding]; other site 1124936004891 active site 1124936004892 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1124936004893 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1124936004894 putative NAD(P) binding site [chemical binding]; other site 1124936004895 catalytic Zn binding site [ion binding]; other site 1124936004896 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1124936004897 ATP-binding site [chemical binding]; other site 1124936004898 Gluconate-6-phosphate binding site [chemical binding]; other site 1124936004899 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1124936004900 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1124936004901 putative NAD(P) binding site [chemical binding]; other site 1124936004902 putative substrate binding site [chemical binding]; other site 1124936004903 catalytic Zn binding site [ion binding]; other site 1124936004904 structural Zn binding site [ion binding]; other site 1124936004905 dimer interface [polypeptide binding]; other site 1124936004906 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1124936004907 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1124936004908 HNH endonuclease; Region: HNH_2; pfam13391 1124936004909 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1124936004910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936004911 ATP binding site [chemical binding]; other site 1124936004912 putative Mg++ binding site [ion binding]; other site 1124936004913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936004914 nucleotide binding region [chemical binding]; other site 1124936004915 ATP-binding site [chemical binding]; other site 1124936004916 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1124936004917 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1124936004918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936004919 ATP binding site [chemical binding]; other site 1124936004920 putative Mg++ binding site [ion binding]; other site 1124936004921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936004922 ATP-binding site [chemical binding]; other site 1124936004923 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1124936004924 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1124936004925 Part of AAA domain; Region: AAA_19; pfam13245 1124936004926 Family description; Region: UvrD_C_2; pfam13538 1124936004927 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1124936004928 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1124936004929 dimer interface [polypeptide binding]; other site 1124936004930 Mn binding site [ion binding]; other site 1124936004931 K binding site [ion binding]; other site 1124936004932 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1124936004933 HNH endonuclease; Region: HNH_2; pfam13391 1124936004934 hypothetical protein; Provisional; Region: PRK12378 1124936004935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936004936 S-adenosylmethionine binding site [chemical binding]; other site 1124936004937 hypothetical protein; Provisional; Region: PRK13687 1124936004938 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1124936004939 Protein of unknown function DUF91; Region: DUF91; cl00709 1124936004940 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1124936004941 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1124936004942 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1124936004943 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1124936004944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936004945 DNA-binding site [nucleotide binding]; DNA binding site 1124936004946 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124936004947 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1124936004948 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1124936004949 active site 1124936004950 HIGH motif; other site 1124936004951 dimer interface [polypeptide binding]; other site 1124936004952 KMSKS motif; other site 1124936004953 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1124936004954 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1124936004955 aspartate racemase; Region: asp_race; TIGR00035 1124936004956 cell density-dependent motility repressor; Provisional; Region: PRK10082 1124936004957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936004958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936004959 dimerization interface [polypeptide binding]; other site 1124936004960 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1124936004961 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1124936004962 dimer interface [polypeptide binding]; other site 1124936004963 active site 1124936004964 hypothetical protein; Provisional; Region: PRK10519 1124936004965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1124936004966 Nucleoside recognition; Region: Gate; pfam07670 1124936004967 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1124936004968 Predicted membrane protein [Function unknown]; Region: COG2733 1124936004969 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1124936004970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936004971 putative substrate translocation pore; other site 1124936004972 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1124936004973 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1124936004974 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1124936004975 NAD(P) binding site [chemical binding]; other site 1124936004976 catalytic residues [active] 1124936004977 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1124936004978 endoribonuclease SymE; Provisional; Region: PRK13605 1124936004979 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1124936004980 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1124936004981 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1124936004982 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1124936004983 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1124936004984 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1124936004985 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1124936004986 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1124936004987 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1124936004988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936004989 ATP binding site [chemical binding]; other site 1124936004990 putative Mg++ binding site [ion binding]; other site 1124936004991 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1124936004992 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1124936004993 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 1124936004994 Restriction endonuclease; Region: Mrr_cat; pfam04471 1124936004995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1124936004996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1124936004997 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1124936004998 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1124936004999 P-loop, Walker A motif; other site 1124936005000 Base recognition motif; other site 1124936005001 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1124936005002 Uncharacterized small protein [Function unknown]; Region: COG2879 1124936005003 carbon starvation protein A; Provisional; Region: PRK15015 1124936005004 Carbon starvation protein CstA; Region: CstA; pfam02554 1124936005005 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1124936005006 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1124936005007 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1124936005008 dimer interface [polypeptide binding]; other site 1124936005009 ligand binding site [chemical binding]; other site 1124936005010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936005011 dimerization interface [polypeptide binding]; other site 1124936005012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936005013 dimer interface [polypeptide binding]; other site 1124936005014 putative CheW interface [polypeptide binding]; other site 1124936005015 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1124936005016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936005017 Walker A motif; other site 1124936005018 ATP binding site [chemical binding]; other site 1124936005019 Walker B motif; other site 1124936005020 arginine finger; other site 1124936005021 Transcriptional antiterminator [Transcription]; Region: COG3933 1124936005022 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936005023 active pocket/dimerization site; other site 1124936005024 active site 1124936005025 phosphorylation site [posttranslational modification] 1124936005026 PRD domain; Region: PRD; pfam00874 1124936005027 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936005028 active pocket/dimerization site; other site 1124936005029 active site 1124936005030 phosphorylation site [posttranslational modification] 1124936005031 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1124936005032 active site 1124936005033 phosphorylation site [posttranslational modification] 1124936005034 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1124936005035 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1124936005036 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1124936005037 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1124936005038 dimer interface [polypeptide binding]; other site 1124936005039 active site 1124936005040 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124936005041 dimer interface [polypeptide binding]; other site 1124936005042 active site 1124936005043 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1124936005044 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1124936005045 putative active site [active] 1124936005046 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1124936005047 phosphoglycerol transferase I; Provisional; Region: PRK03776 1124936005048 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1124936005049 hypothetical protein; Provisional; Region: PRK11667 1124936005050 DNA replication protein DnaC; Validated; Region: PRK07952 1124936005051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936005052 Walker A motif; other site 1124936005053 ATP binding site [chemical binding]; other site 1124936005054 Walker B motif; other site 1124936005055 primosomal protein DnaI; Provisional; Region: PRK02854 1124936005056 hypothetical protein; Provisional; Region: PRK09917 1124936005057 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1124936005058 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1124936005059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124936005060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936005061 DNA binding residues [nucleotide binding] 1124936005062 dimerization interface [polypeptide binding]; other site 1124936005063 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1124936005064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936005065 DNA binding residues [nucleotide binding] 1124936005066 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1124936005067 putative deacylase active site [active] 1124936005068 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1124936005069 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1124936005070 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1124936005071 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124936005072 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936005073 metal binding site [ion binding]; metal-binding site 1124936005074 active site 1124936005075 I-site; other site 1124936005076 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1124936005077 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1124936005078 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1124936005079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936005080 S-adenosylmethionine binding site [chemical binding]; other site 1124936005081 DNA polymerase III subunit psi; Validated; Region: PRK06856 1124936005082 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1124936005083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936005084 Coenzyme A binding pocket [chemical binding]; other site 1124936005085 dUMP phosphatase; Provisional; Region: PRK09449 1124936005086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936005087 motif II; other site 1124936005088 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1124936005089 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1124936005090 G1 box; other site 1124936005091 putative GEF interaction site [polypeptide binding]; other site 1124936005092 GTP/Mg2+ binding site [chemical binding]; other site 1124936005093 Switch I region; other site 1124936005094 G2 box; other site 1124936005095 G3 box; other site 1124936005096 Switch II region; other site 1124936005097 G4 box; other site 1124936005098 G5 box; other site 1124936005099 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1124936005100 periplasmic protein; Provisional; Region: PRK10568 1124936005101 BON domain; Region: BON; pfam04972 1124936005102 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1124936005103 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1124936005104 active site 1124936005105 nucleophile elbow; other site 1124936005106 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1124936005107 active site 1124936005108 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1124936005109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936005110 FeS/SAM binding site; other site 1124936005111 hypothetical protein; Provisional; Region: PRK10977 1124936005112 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1124936005113 intersubunit interface [polypeptide binding]; other site 1124936005114 active site 1124936005115 catalytic residue [active] 1124936005116 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1124936005117 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1124936005118 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1124936005119 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1124936005120 phosphopentomutase; Provisional; Region: PRK05362 1124936005121 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1124936005122 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1124936005123 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1124936005124 hypothetical protein; Provisional; Region: PRK15301 1124936005125 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1124936005126 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936005127 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936005128 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936005129 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1124936005130 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005131 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005132 hypothetical protein; Provisional; Region: PRK15302 1124936005133 hypothetical protein; Provisional; Region: PRK15303 1124936005134 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1124936005135 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1124936005136 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1124936005137 hypothetical protein; Provisional; Region: PRK11246 1124936005138 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1124936005139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936005140 motif II; other site 1124936005141 DNA repair protein RadA; Region: sms; TIGR00416 1124936005142 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1124936005143 Walker A motif/ATP binding site; other site 1124936005144 ATP binding site [chemical binding]; other site 1124936005145 Walker B motif; other site 1124936005146 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1124936005147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936005148 non-specific DNA binding site [nucleotide binding]; other site 1124936005149 salt bridge; other site 1124936005150 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1124936005151 sequence-specific DNA binding site [nucleotide binding]; other site 1124936005152 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1124936005153 active site 1124936005154 (T/H)XGH motif; other site 1124936005155 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1124936005156 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1124936005157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936005158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936005159 ABC transporter; Region: ABC_tran_2; pfam12848 1124936005160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936005161 lytic murein transglycosylase; Provisional; Region: PRK11619 1124936005162 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936005163 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936005164 catalytic residue [active] 1124936005165 Trp operon repressor; Provisional; Region: PRK01381 1124936005166 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1124936005167 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124936005168 catalytic core [active] 1124936005169 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1124936005170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936005171 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1124936005172 hypothetical protein; Provisional; Region: PRK10756 1124936005173 CreA protein; Region: CreA; pfam05981 1124936005174 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1124936005175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936005176 active site 1124936005177 phosphorylation site [posttranslational modification] 1124936005178 intermolecular recognition site; other site 1124936005179 dimerization interface [polypeptide binding]; other site 1124936005180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936005181 DNA binding site [nucleotide binding] 1124936005182 sensory histidine kinase CreC; Provisional; Region: PRK11100 1124936005183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124936005184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936005185 dimer interface [polypeptide binding]; other site 1124936005186 phosphorylation site [posttranslational modification] 1124936005187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936005188 ATP binding site [chemical binding]; other site 1124936005189 Mg2+ binding site [ion binding]; other site 1124936005190 G-X-G motif; other site 1124936005191 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1124936005192 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1124936005193 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1124936005194 putative fimbrial protein SthD; Provisional; Region: PRK15293 1124936005195 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 1124936005196 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936005197 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936005198 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936005199 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1124936005200 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005201 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005202 putative fimbrial protein SthA; Provisional; Region: PRK15296 1124936005203 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1124936005204 Helix-turn-helix domain; Region: HTH_36; pfam13730 1124936005205 two-component response regulator; Provisional; Region: PRK11173 1124936005206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936005207 active site 1124936005208 phosphorylation site [posttranslational modification] 1124936005209 intermolecular recognition site; other site 1124936005210 dimerization interface [polypeptide binding]; other site 1124936005211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936005212 DNA binding site [nucleotide binding] 1124936005213 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1124936005214 putative RNA methyltransferase; Provisional; Region: PRK10433 1124936005215 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1124936005216 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1124936005217 putative catalytic residues [active] 1124936005218 putative nucleotide binding site [chemical binding]; other site 1124936005219 putative aspartate binding site [chemical binding]; other site 1124936005220 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1124936005221 dimer interface [polypeptide binding]; other site 1124936005222 putative threonine allosteric regulatory site; other site 1124936005223 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1124936005224 putative threonine allosteric regulatory site; other site 1124936005225 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1124936005226 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1124936005227 homoserine kinase; Provisional; Region: PRK01212 1124936005228 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1124936005229 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1124936005230 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1124936005231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936005232 catalytic residue [active] 1124936005233 hypothetical protein; Validated; Region: PRK02101 1124936005234 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1124936005235 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1124936005236 transaldolase-like protein; Provisional; Region: PTZ00411 1124936005237 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1124936005238 active site 1124936005239 dimer interface [polypeptide binding]; other site 1124936005240 catalytic residue [active] 1124936005241 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1124936005242 MPT binding site; other site 1124936005243 trimer interface [polypeptide binding]; other site 1124936005244 hypothetical protein; Provisional; Region: PRK10659 1124936005245 hypothetical protein; Provisional; Region: PRK10236 1124936005246 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1124936005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1124936005248 hypothetical protein; Provisional; Region: PRK10154 1124936005249 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1124936005250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1124936005251 nucleotide binding site [chemical binding]; other site 1124936005252 chaperone protein DnaJ; Provisional; Region: PRK10767 1124936005253 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124936005254 HSP70 interaction site [polypeptide binding]; other site 1124936005255 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1124936005256 substrate binding site [polypeptide binding]; other site 1124936005257 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1124936005258 Zn binding sites [ion binding]; other site 1124936005259 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1124936005260 dimer interface [polypeptide binding]; other site 1124936005261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936005262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936005263 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124936005264 substrate binding pocket [chemical binding]; other site 1124936005265 dimerization interface [polypeptide binding]; other site 1124936005266 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1124936005267 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1124936005268 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1124936005269 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1124936005270 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1124936005271 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1124936005272 active site 1124936005273 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1124936005274 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1124936005275 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1124936005276 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1124936005277 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1124936005278 Helix-turn-helix domain; Region: HTH_36; pfam13730 1124936005279 fimbrial protein BcfA; Provisional; Region: PRK15187 1124936005280 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 1124936005281 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005282 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005283 outer membrane usher protein; Provisional; Region: PRK15193 1124936005284 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936005285 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936005286 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936005287 fimbrial protein BcfD; Provisional; Region: PRK15189 1124936005288 fimbrial protein BcfE; Provisional; Region: PRK15190 1124936005289 fimbrial protein BcfF; Provisional; Region: PRK15191 1124936005290 fimbrial chaperone BcfG; Provisional; Region: PRK15192 1124936005291 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005292 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005293 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1124936005294 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1124936005295 catalytic residues [active] 1124936005296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1124936005297 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1124936005298 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 1124936005299 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1124936005300 Sulfatase; Region: Sulfatase; pfam00884 1124936005301 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1124936005302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936005303 FeS/SAM binding site; other site 1124936005304 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124936005305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1124936005306 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1124936005307 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1124936005308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936005309 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1124936005310 putative dimerization interface [polypeptide binding]; other site 1124936005311 putative alpha-glucosidase; Provisional; Region: PRK10658 1124936005312 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1124936005313 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1124936005314 putative active site [active] 1124936005315 putative catalytic site [active] 1124936005316 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1124936005317 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1124936005318 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1124936005319 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 1124936005320 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1124936005321 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1124936005322 active site 1124936005323 Riboflavin kinase; Region: Flavokinase; smart00904 1124936005324 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1124936005325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124936005326 active site 1124936005327 HIGH motif; other site 1124936005328 nucleotide binding site [chemical binding]; other site 1124936005329 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1124936005330 active site 1124936005331 KMSKS motif; other site 1124936005332 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1124936005333 tRNA binding surface [nucleotide binding]; other site 1124936005334 anticodon binding site; other site 1124936005335 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1124936005336 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1124936005337 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1124936005338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124936005339 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1124936005340 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1124936005341 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1124936005342 active site 1124936005343 tetramer interface [polypeptide binding]; other site 1124936005344 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1124936005345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936005346 active site 1124936005347 phosphorylation site [posttranslational modification] 1124936005348 intermolecular recognition site; other site 1124936005349 dimerization interface [polypeptide binding]; other site 1124936005350 Transcriptional regulator; Region: CitT; pfam12431 1124936005351 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1124936005352 PAS domain; Region: PAS; smart00091 1124936005353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936005354 ATP binding site [chemical binding]; other site 1124936005355 Mg2+ binding site [ion binding]; other site 1124936005356 G-X-G motif; other site 1124936005357 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1124936005358 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1124936005359 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1124936005360 active site 1124936005361 catalytic residues [active] 1124936005362 metal binding site [ion binding]; metal-binding site 1124936005363 homodimer binding site [polypeptide binding]; other site 1124936005364 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124936005365 carboxyltransferase (CT) interaction site; other site 1124936005366 biotinylation site [posttranslational modification]; other site 1124936005367 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1124936005368 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1124936005369 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1124936005370 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1124936005371 putative active site [active] 1124936005372 (T/H)XGH motif; other site 1124936005373 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1124936005374 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1124936005375 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1124936005376 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1124936005377 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1124936005378 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1124936005379 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1124936005380 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1124936005381 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1124936005382 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1124936005383 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1124936005384 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1124936005385 catalytic site [active] 1124936005386 subunit interface [polypeptide binding]; other site 1124936005387 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1124936005388 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124936005389 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124936005390 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1124936005391 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124936005392 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124936005393 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1124936005394 IMP binding site; other site 1124936005395 dimer interface [polypeptide binding]; other site 1124936005396 interdomain contacts; other site 1124936005397 partial ornithine binding site; other site 1124936005398 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1124936005399 carnitine operon protein CaiE; Provisional; Region: PRK13627 1124936005400 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1124936005401 putative trimer interface [polypeptide binding]; other site 1124936005402 putative metal binding site [ion binding]; other site 1124936005403 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1124936005404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124936005405 substrate binding site [chemical binding]; other site 1124936005406 oxyanion hole (OAH) forming residues; other site 1124936005407 trimer interface [polypeptide binding]; other site 1124936005408 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1124936005409 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1124936005410 acyl-activating enzyme (AAE) consensus motif; other site 1124936005411 putative AMP binding site [chemical binding]; other site 1124936005412 putative active site [active] 1124936005413 putative CoA binding site [chemical binding]; other site 1124936005414 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1124936005415 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124936005416 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1124936005417 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1124936005418 active site 1124936005419 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1124936005420 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1124936005421 Ligand binding site [chemical binding]; other site 1124936005422 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1124936005423 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1124936005424 Electron transfer flavoprotein domain; Region: ETF; smart00893 1124936005425 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1124936005426 putative oxidoreductase FixC; Provisional; Region: PRK10157 1124936005427 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1124936005428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936005429 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1124936005430 putative substrate translocation pore; other site 1124936005431 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124936005432 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936005433 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1124936005434 Sulfatase; Region: Sulfatase; cl17466 1124936005435 Sulfatase; Region: Sulfatase; cl17466 1124936005436 Sulfatase; Region: Sulfatase; cl17466 1124936005437 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1124936005438 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1124936005439 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1124936005440 TrkA-N domain; Region: TrkA_N; pfam02254 1124936005441 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1124936005442 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1124936005443 folate binding site [chemical binding]; other site 1124936005444 NADP+ binding site [chemical binding]; other site 1124936005445 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1124936005446 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1124936005447 active site 1124936005448 metal binding site [ion binding]; metal-binding site 1124936005449 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1124936005450 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1124936005451 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1124936005452 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1124936005453 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1124936005454 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1124936005455 SurA N-terminal domain; Region: SurA_N; pfam09312 1124936005456 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1124936005457 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1124936005458 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1124936005459 OstA-like protein; Region: OstA; pfam03968 1124936005460 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1124936005461 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1124936005462 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1124936005463 putative metal binding site [ion binding]; other site 1124936005464 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124936005465 HSP70 interaction site [polypeptide binding]; other site 1124936005466 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1124936005467 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1124936005468 active site 1124936005469 ATP-dependent helicase HepA; Validated; Region: PRK04914 1124936005470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936005471 ATP binding site [chemical binding]; other site 1124936005472 putative Mg++ binding site [ion binding]; other site 1124936005473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936005474 nucleotide binding region [chemical binding]; other site 1124936005475 ATP-binding site [chemical binding]; other site 1124936005476 DNA polymerase II; Reviewed; Region: PRK05762 1124936005477 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1124936005478 active site 1124936005479 catalytic site [active] 1124936005480 substrate binding site [chemical binding]; other site 1124936005481 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1124936005482 active site 1124936005483 metal-binding site 1124936005484 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1124936005485 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1124936005486 putative active site [active] 1124936005487 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1124936005488 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1124936005489 intersubunit interface [polypeptide binding]; other site 1124936005490 active site 1124936005491 Zn2+ binding site [ion binding]; other site 1124936005492 L-arabinose isomerase; Provisional; Region: PRK02929 1124936005493 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1124936005494 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1124936005495 trimer interface [polypeptide binding]; other site 1124936005496 putative substrate binding site [chemical binding]; other site 1124936005497 putative metal binding site [ion binding]; other site 1124936005498 ribulokinase; Provisional; Region: PRK04123 1124936005499 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1124936005500 N- and C-terminal domain interface [polypeptide binding]; other site 1124936005501 active site 1124936005502 MgATP binding site [chemical binding]; other site 1124936005503 catalytic site [active] 1124936005504 metal binding site [ion binding]; metal-binding site 1124936005505 carbohydrate binding site [chemical binding]; other site 1124936005506 homodimer interface [polypeptide binding]; other site 1124936005507 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1124936005508 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124936005509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936005510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936005511 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124936005512 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1124936005513 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1124936005514 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1124936005515 Walker A/P-loop; other site 1124936005516 ATP binding site [chemical binding]; other site 1124936005517 Q-loop/lid; other site 1124936005518 ABC transporter signature motif; other site 1124936005519 Walker B; other site 1124936005520 D-loop; other site 1124936005521 H-loop/switch region; other site 1124936005522 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1124936005523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936005524 dimer interface [polypeptide binding]; other site 1124936005525 conserved gate region; other site 1124936005526 putative PBP binding loops; other site 1124936005527 ABC-ATPase subunit interface; other site 1124936005528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936005529 dimer interface [polypeptide binding]; other site 1124936005530 conserved gate region; other site 1124936005531 putative PBP binding loops; other site 1124936005532 ABC-ATPase subunit interface; other site 1124936005533 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1124936005534 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1124936005535 transcriptional regulator SgrR; Provisional; Region: PRK13626 1124936005536 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1124936005537 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1124936005538 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1124936005539 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1124936005540 substrate binding site [chemical binding]; other site 1124936005541 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1124936005542 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1124936005543 substrate binding site [chemical binding]; other site 1124936005544 ligand binding site [chemical binding]; other site 1124936005545 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1124936005546 tartrate dehydrogenase; Region: TTC; TIGR02089 1124936005547 2-isopropylmalate synthase; Validated; Region: PRK00915 1124936005548 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1124936005549 active site 1124936005550 catalytic residues [active] 1124936005551 metal binding site [ion binding]; metal-binding site 1124936005552 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1124936005553 leu operon leader peptide; Provisional; Region: PRK14744 1124936005554 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1124936005555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936005556 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1124936005557 putative substrate binding pocket [chemical binding]; other site 1124936005558 putative dimerization interface [polypeptide binding]; other site 1124936005559 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1124936005560 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124936005561 PYR/PP interface [polypeptide binding]; other site 1124936005562 dimer interface [polypeptide binding]; other site 1124936005563 TPP binding site [chemical binding]; other site 1124936005564 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124936005565 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1124936005566 TPP-binding site [chemical binding]; other site 1124936005567 dimer interface [polypeptide binding]; other site 1124936005568 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1124936005569 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1124936005570 putative valine binding site [chemical binding]; other site 1124936005571 dimer interface [polypeptide binding]; other site 1124936005572 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1124936005573 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1124936005574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936005575 DNA binding site [nucleotide binding] 1124936005576 domain linker motif; other site 1124936005577 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1124936005578 dimerization interface [polypeptide binding]; other site 1124936005579 ligand binding site [chemical binding]; other site 1124936005580 mraZ protein; Region: TIGR00242 1124936005581 MraZ protein; Region: MraZ; pfam02381 1124936005582 MraZ protein; Region: MraZ; pfam02381 1124936005583 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1124936005584 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1124936005585 cell division protein FtsL; Provisional; Region: PRK10772 1124936005586 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1124936005587 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124936005588 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124936005589 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1124936005590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124936005591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124936005592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124936005593 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1124936005594 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124936005595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124936005596 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124936005597 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1124936005598 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1124936005599 Mg++ binding site [ion binding]; other site 1124936005600 putative catalytic motif [active] 1124936005601 putative substrate binding site [chemical binding]; other site 1124936005602 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1124936005603 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124936005604 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124936005605 cell division protein FtsW; Provisional; Region: PRK10774 1124936005606 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1124936005607 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1124936005608 active site 1124936005609 homodimer interface [polypeptide binding]; other site 1124936005610 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1124936005611 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124936005612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124936005613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124936005614 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1124936005615 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1124936005616 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1124936005617 cell division protein FtsQ; Provisional; Region: PRK10775 1124936005618 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1124936005619 Cell division protein FtsQ; Region: FtsQ; pfam03799 1124936005620 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1124936005621 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936005622 Cell division protein FtsA; Region: FtsA; pfam14450 1124936005623 cell division protein FtsZ; Validated; Region: PRK09330 1124936005624 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1124936005625 nucleotide binding site [chemical binding]; other site 1124936005626 SulA interaction site; other site 1124936005627 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1124936005628 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1124936005629 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1124936005630 SecA regulator SecM; Provisional; Region: PRK02943 1124936005631 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1124936005632 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1124936005633 SEC-C motif; Region: SEC-C; pfam02810 1124936005634 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1124936005635 active site 1124936005636 8-oxo-dGMP binding site [chemical binding]; other site 1124936005637 nudix motif; other site 1124936005638 metal binding site [ion binding]; metal-binding site 1124936005639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1124936005640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936005641 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1124936005642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1124936005643 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1124936005644 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1124936005645 CoA-binding site [chemical binding]; other site 1124936005646 ATP-binding [chemical binding]; other site 1124936005647 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1124936005648 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1124936005649 active site 1124936005650 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1124936005651 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124936005652 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124936005653 hypothetical protein; Provisional; Region: PRK10436 1124936005654 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1124936005655 Walker A motif; other site 1124936005656 ATP binding site [chemical binding]; other site 1124936005657 Walker B motif; other site 1124936005658 putative major pilin subunit; Provisional; Region: PRK10574 1124936005659 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1124936005660 Pilin (bacterial filament); Region: Pilin; pfam00114 1124936005661 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1124936005662 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1124936005663 dimerization interface [polypeptide binding]; other site 1124936005664 active site 1124936005665 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1124936005666 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1124936005667 amidase catalytic site [active] 1124936005668 Zn binding residues [ion binding]; other site 1124936005669 substrate binding site [chemical binding]; other site 1124936005670 regulatory protein AmpE; Provisional; Region: PRK10987 1124936005671 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1124936005672 active site 1124936005673 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1124936005674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936005675 putative substrate translocation pore; other site 1124936005676 aromatic amino acid transporter; Provisional; Region: PRK10238 1124936005677 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1124936005678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936005679 DNA-binding site [nucleotide binding]; DNA binding site 1124936005680 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124936005681 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1124936005682 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1124936005683 dimer interface [polypeptide binding]; other site 1124936005684 TPP-binding site [chemical binding]; other site 1124936005685 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1124936005686 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124936005687 E3 interaction surface; other site 1124936005688 lipoyl attachment site [posttranslational modification]; other site 1124936005689 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124936005690 E3 interaction surface; other site 1124936005691 lipoyl attachment site [posttranslational modification]; other site 1124936005692 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124936005693 E3 interaction surface; other site 1124936005694 lipoyl attachment site [posttranslational modification]; other site 1124936005695 e3 binding domain; Region: E3_binding; pfam02817 1124936005696 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1124936005697 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1124936005698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124936005699 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936005700 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124936005701 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1124936005702 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1124936005703 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1124936005704 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1124936005705 substrate binding site [chemical binding]; other site 1124936005706 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1124936005707 substrate binding site [chemical binding]; other site 1124936005708 ligand binding site [chemical binding]; other site 1124936005709 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1124936005710 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1124936005711 aconitate hydratase 2; Provisional; Region: PLN00094 1124936005712 putative inner membrane protein; Provisional; Region: PRK09823 1124936005713 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1124936005714 active site 1124936005715 hypothetical protein; Provisional; Region: PRK05248 1124936005716 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1124936005717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1124936005718 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1124936005719 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1124936005720 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1124936005721 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936005722 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936005723 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936005724 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1124936005725 spermidine synthase; Provisional; Region: PRK00811 1124936005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936005727 S-adenosylmethionine binding site [chemical binding]; other site 1124936005728 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1124936005729 multicopper oxidase; Provisional; Region: PRK10965 1124936005730 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1124936005731 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1124936005732 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1124936005733 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1124936005734 Trp docking motif [polypeptide binding]; other site 1124936005735 putative active site [active] 1124936005736 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1124936005737 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936005738 active site 1124936005739 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1124936005740 active site clefts [active] 1124936005741 zinc binding site [ion binding]; other site 1124936005742 dimer interface [polypeptide binding]; other site 1124936005743 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1124936005744 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124936005745 Walker A/P-loop; other site 1124936005746 ATP binding site [chemical binding]; other site 1124936005747 Q-loop/lid; other site 1124936005748 ABC transporter signature motif; other site 1124936005749 Walker B; other site 1124936005750 D-loop; other site 1124936005751 H-loop/switch region; other site 1124936005752 inner membrane transport permease; Provisional; Region: PRK15066 1124936005753 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124936005754 putative fimbrial protein StiH; Provisional; Region: PRK15297 1124936005755 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 1124936005756 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936005757 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936005758 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936005759 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 1124936005760 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005761 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005762 fimbrial protein StiA; Provisional; Region: PRK15300 1124936005763 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936005764 active pocket/dimerization site; other site 1124936005765 active site 1124936005766 phosphorylation site [posttranslational modification] 1124936005767 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1124936005768 putative active site [active] 1124936005769 putative metal binding site [ion binding]; other site 1124936005770 putative fimbrial protein StkG; Provisional; Region: PRK15305 1124936005771 putative fimbrial protein StaF; Provisional; Region: PRK15262 1124936005772 putative fimbrial protein StaE; Provisional; Region: PRK15263 1124936005773 putative fimbrial protein StkD; Provisional; Region: PRK15306 1124936005774 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1124936005775 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936005776 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936005777 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936005778 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1124936005779 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005780 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005781 major fimbrial protein StkA; Provisional; Region: PRK15307 1124936005782 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1124936005783 tetramerization interface [polypeptide binding]; other site 1124936005784 active site 1124936005785 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1124936005786 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1124936005787 active site 1124936005788 ATP-binding site [chemical binding]; other site 1124936005789 pantoate-binding site; other site 1124936005790 HXXH motif; other site 1124936005791 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1124936005792 oligomerization interface [polypeptide binding]; other site 1124936005793 active site 1124936005794 metal binding site [ion binding]; metal-binding site 1124936005795 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1124936005796 catalytic center binding site [active] 1124936005797 ATP binding site [chemical binding]; other site 1124936005798 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1124936005799 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1124936005800 active site 1124936005801 NTP binding site [chemical binding]; other site 1124936005802 metal binding triad [ion binding]; metal-binding site 1124936005803 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1124936005804 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1124936005805 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1124936005806 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1124936005807 active site 1124936005808 nucleotide binding site [chemical binding]; other site 1124936005809 HIGH motif; other site 1124936005810 KMSKS motif; other site 1124936005811 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1124936005812 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1124936005813 2'-5' RNA ligase; Provisional; Region: PRK15124 1124936005814 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1124936005815 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1124936005816 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1124936005817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936005818 ATP binding site [chemical binding]; other site 1124936005819 putative Mg++ binding site [ion binding]; other site 1124936005820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936005821 nucleotide binding region [chemical binding]; other site 1124936005822 ATP-binding site [chemical binding]; other site 1124936005823 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1124936005824 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1124936005825 Transglycosylase; Region: Transgly; pfam00912 1124936005826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1124936005827 potential frameshift: common BLAST hit: gi|197250727|ref|YP_002145194.1| ferrichrome outer membrane transporter 1124936005828 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1124936005829 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124936005830 Walker A/P-loop; other site 1124936005831 ATP binding site [chemical binding]; other site 1124936005832 Q-loop/lid; other site 1124936005833 ABC transporter signature motif; other site 1124936005834 Walker B; other site 1124936005835 D-loop; other site 1124936005836 H-loop/switch region; other site 1124936005837 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1124936005838 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1124936005839 siderophore binding site; other site 1124936005840 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124936005841 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936005842 ABC-ATPase subunit interface; other site 1124936005843 dimer interface [polypeptide binding]; other site 1124936005844 putative PBP binding regions; other site 1124936005845 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936005846 ABC-ATPase subunit interface; other site 1124936005847 dimer interface [polypeptide binding]; other site 1124936005848 putative PBP binding regions; other site 1124936005849 putative fimbrial subunit StfA; Provisional; Region: PRK15283 1124936005850 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1124936005851 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936005852 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936005853 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936005854 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1124936005855 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936005856 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936005857 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 1124936005858 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 1124936005859 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 1124936005860 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1124936005861 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1124936005862 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124936005863 inhibitor-cofactor binding pocket; inhibition site 1124936005864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936005865 catalytic residue [active] 1124936005866 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1124936005867 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1124936005868 Cl- selectivity filter; other site 1124936005869 Cl- binding residues [ion binding]; other site 1124936005870 pore gating glutamate residue; other site 1124936005871 dimer interface [polypeptide binding]; other site 1124936005872 H+/Cl- coupling transport residue; other site 1124936005873 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1124936005874 hypothetical protein; Provisional; Region: PRK10578 1124936005875 UPF0126 domain; Region: UPF0126; pfam03458 1124936005876 UPF0126 domain; Region: UPF0126; pfam03458 1124936005877 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1124936005878 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1124936005879 cobalamin binding residues [chemical binding]; other site 1124936005880 putative BtuC binding residues; other site 1124936005881 dimer interface [polypeptide binding]; other site 1124936005882 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1124936005883 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1124936005884 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1124936005885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124936005886 Zn2+ binding site [ion binding]; other site 1124936005887 Mg2+ binding site [ion binding]; other site 1124936005888 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1124936005889 serine endoprotease; Provisional; Region: PRK10942 1124936005890 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1124936005891 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124936005892 protein binding site [polypeptide binding]; other site 1124936005893 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124936005894 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1124936005895 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1124936005896 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1124936005897 hypothetical protein; Provisional; Region: PRK13677 1124936005898 shikimate transporter; Provisional; Region: PRK09952 1124936005899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936005900 putative substrate translocation pore; other site 1124936005901 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1124936005902 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1124936005903 trimer interface [polypeptide binding]; other site 1124936005904 active site 1124936005905 substrate binding site [chemical binding]; other site 1124936005906 CoA binding site [chemical binding]; other site 1124936005907 PII uridylyl-transferase; Provisional; Region: PRK05007 1124936005908 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124936005909 metal binding triad; other site 1124936005910 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1124936005911 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124936005912 Zn2+ binding site [ion binding]; other site 1124936005913 Mg2+ binding site [ion binding]; other site 1124936005914 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1124936005915 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1124936005916 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1124936005917 active site 1124936005918 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1124936005919 rRNA interaction site [nucleotide binding]; other site 1124936005920 S8 interaction site; other site 1124936005921 putative laminin-1 binding site; other site 1124936005922 elongation factor Ts; Provisional; Region: tsf; PRK09377 1124936005923 UBA/TS-N domain; Region: UBA; pfam00627 1124936005924 Elongation factor TS; Region: EF_TS; pfam00889 1124936005925 Elongation factor TS; Region: EF_TS; pfam00889 1124936005926 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1124936005927 putative nucleotide binding site [chemical binding]; other site 1124936005928 uridine monophosphate binding site [chemical binding]; other site 1124936005929 homohexameric interface [polypeptide binding]; other site 1124936005930 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1124936005931 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1124936005932 hinge region; other site 1124936005933 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1124936005934 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1124936005935 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1124936005936 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1124936005937 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1124936005938 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1124936005939 catalytic residue [active] 1124936005940 putative FPP diphosphate binding site; other site 1124936005941 putative FPP binding hydrophobic cleft; other site 1124936005942 dimer interface [polypeptide binding]; other site 1124936005943 putative IPP diphosphate binding site; other site 1124936005944 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1124936005945 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1124936005946 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1124936005947 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1124936005948 active site 1124936005949 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1124936005950 protein binding site [polypeptide binding]; other site 1124936005951 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1124936005952 protein binding site [polypeptide binding]; other site 1124936005953 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1124936005954 putative substrate binding region [chemical binding]; other site 1124936005955 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1124936005956 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124936005957 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124936005958 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124936005959 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124936005960 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124936005961 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124936005962 periplasmic chaperone; Provisional; Region: PRK10780 1124936005963 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1124936005964 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1124936005965 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1124936005966 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1124936005967 trimer interface [polypeptide binding]; other site 1124936005968 active site 1124936005969 UDP-GlcNAc binding site [chemical binding]; other site 1124936005970 lipid binding site [chemical binding]; lipid-binding site 1124936005971 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1124936005972 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1124936005973 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1124936005974 active site 1124936005975 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1124936005976 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1124936005977 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1124936005978 RNA/DNA hybrid binding site [nucleotide binding]; other site 1124936005979 active site 1124936005980 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1124936005981 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1124936005982 putative active site [active] 1124936005983 putative PHP Thumb interface [polypeptide binding]; other site 1124936005984 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1124936005985 generic binding surface II; other site 1124936005986 generic binding surface I; other site 1124936005987 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1124936005988 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1124936005989 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1124936005990 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1124936005991 putative sugar binding site [chemical binding]; other site 1124936005992 catalytic residues [active] 1124936005993 PKD domain; Region: PKD; pfam00801 1124936005994 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1124936005995 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1124936005996 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1124936005997 homodimer interface [polypeptide binding]; other site 1124936005998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936005999 catalytic residue [active] 1124936006000 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1124936006001 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1124936006002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124936006003 putative metal binding site [ion binding]; other site 1124936006004 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1124936006005 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1124936006006 Ligand Binding Site [chemical binding]; other site 1124936006007 TilS substrate binding domain; Region: TilS; pfam09179 1124936006008 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1124936006009 Rho-binding antiterminator; Provisional; Region: PRK11625 1124936006010 hypothetical protein; Provisional; Region: PRK04964 1124936006011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1124936006012 hypothetical protein; Provisional; Region: PRK09256 1124936006013 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1124936006014 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1124936006015 NlpE N-terminal domain; Region: NlpE; pfam04170 1124936006016 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1124936006017 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1124936006018 dimer interface [polypeptide binding]; other site 1124936006019 motif 1; other site 1124936006020 active site 1124936006021 motif 2; other site 1124936006022 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1124936006023 putative deacylase active site [active] 1124936006024 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1124936006025 active site 1124936006026 motif 3; other site 1124936006027 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1124936006028 anticodon binding site; other site 1124936006029 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1124936006030 homodimer interaction site [polypeptide binding]; other site 1124936006031 cofactor binding site; other site 1124936006032 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1124936006033 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1124936006034 lipoprotein, YaeC family; Region: TIGR00363 1124936006035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936006036 dimer interface [polypeptide binding]; other site 1124936006037 conserved gate region; other site 1124936006038 ABC-ATPase subunit interface; other site 1124936006039 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1124936006040 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1124936006041 Walker A/P-loop; other site 1124936006042 ATP binding site [chemical binding]; other site 1124936006043 Q-loop/lid; other site 1124936006044 ABC transporter signature motif; other site 1124936006045 Walker B; other site 1124936006046 D-loop; other site 1124936006047 H-loop/switch region; other site 1124936006048 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1124936006049 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1124936006050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936006051 active site 1124936006052 motif I; other site 1124936006053 motif II; other site 1124936006054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936006055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936006056 active site 1124936006057 catalytic tetrad [active] 1124936006058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936006059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936006060 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1124936006061 putative effector binding pocket; other site 1124936006062 dimerization interface [polypeptide binding]; other site 1124936006063 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124936006064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006065 putative substrate translocation pore; other site 1124936006066 hypothetical protein; Provisional; Region: PRK05421 1124936006067 putative catalytic site [active] 1124936006068 putative metal binding site [ion binding]; other site 1124936006069 putative phosphate binding site [ion binding]; other site 1124936006070 putative catalytic site [active] 1124936006071 putative phosphate binding site [ion binding]; other site 1124936006072 putative metal binding site [ion binding]; other site 1124936006073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936006074 S-adenosylmethionine binding site [chemical binding]; other site 1124936006075 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1124936006076 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936006077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936006078 catalytic residue [active] 1124936006079 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936006080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936006081 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1124936006082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936006083 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1124936006084 RNA/DNA hybrid binding site [nucleotide binding]; other site 1124936006085 active site 1124936006086 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1124936006087 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1124936006088 active site 1124936006089 catalytic site [active] 1124936006090 substrate binding site [chemical binding]; other site 1124936006091 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1124936006092 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1124936006093 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1124936006094 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1124936006095 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1124936006096 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1124936006097 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1124936006098 ImpE protein; Region: ImpE; pfam07024 1124936006099 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1124936006100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936006101 Walker A motif; other site 1124936006102 ATP binding site [chemical binding]; other site 1124936006103 Walker B motif; other site 1124936006104 arginine finger; other site 1124936006105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936006106 Walker A motif; other site 1124936006107 ATP binding site [chemical binding]; other site 1124936006108 Walker B motif; other site 1124936006109 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124936006110 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1124936006111 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1124936006112 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1124936006113 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1124936006114 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1124936006115 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1124936006116 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1124936006117 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1124936006118 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1124936006119 hypothetical protein; Provisional; Region: PRK08126 1124936006120 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1124936006121 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124936006122 ligand binding site [chemical binding]; other site 1124936006123 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1124936006124 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1124936006125 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1124936006126 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1124936006127 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1124936006128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 1124936006129 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1124936006130 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1124936006131 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1124936006132 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1124936006133 PAAR motif; Region: PAAR_motif; pfam05488 1124936006134 RHS Repeat; Region: RHS_repeat; cl11982 1124936006135 RHS Repeat; Region: RHS_repeat; cl11982 1124936006136 RHS Repeat; Region: RHS_repeat; cl11982 1124936006137 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006138 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006139 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1124936006140 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006141 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006142 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006143 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006144 RHS Repeat; Region: RHS_repeat; pfam05593 1124936006145 RHS protein; Region: RHS; pfam03527 1124936006146 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1124936006147 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1124936006148 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1124936006149 Transposase; Region: HTH_Tnp_1; cl17663 1124936006150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1124936006151 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1124936006152 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1124936006153 putative fimbrial subunit TcfB; Provisional; Region: PRK15309 1124936006154 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1124936006155 putative fimbrial protein TcfD; Provisional; Region: PRK15311 1124936006156 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124936006157 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1124936006158 AsnC family; Region: AsnC_trans_reg; pfam01037 1124936006159 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1124936006160 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1124936006161 dimer interface [polypeptide binding]; other site 1124936006162 C-N hydrolase family amidase; Provisional; Region: PRK10438 1124936006163 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1124936006164 putative active site [active] 1124936006165 catalytic triad [active] 1124936006166 dimer interface [polypeptide binding]; other site 1124936006167 multimer interface [polypeptide binding]; other site 1124936006168 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1124936006169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124936006170 active site 1124936006171 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1124936006172 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1124936006173 dimer interface [polypeptide binding]; other site 1124936006174 active site 1124936006175 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1124936006176 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1124936006177 putative active site [active] 1124936006178 putative dimer interface [polypeptide binding]; other site 1124936006179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1124936006180 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936006181 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1124936006182 active site 1124936006183 DNA polymerase IV; Validated; Region: PRK02406 1124936006184 DNA binding site [nucleotide binding] 1124936006185 hypothetical protein; Reviewed; Region: PRK09588 1124936006186 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1124936006187 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1124936006188 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1124936006189 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1124936006190 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1124936006191 metal binding site [ion binding]; metal-binding site 1124936006192 dimer interface [polypeptide binding]; other site 1124936006193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936006194 active site 1124936006195 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1124936006196 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1124936006197 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936006198 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936006199 trimer interface [polypeptide binding]; other site 1124936006200 eyelet of channel; other site 1124936006201 gamma-glutamyl kinase; Provisional; Region: PRK05429 1124936006202 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1124936006203 nucleotide binding site [chemical binding]; other site 1124936006204 homotetrameric interface [polypeptide binding]; other site 1124936006205 putative phosphate binding site [ion binding]; other site 1124936006206 putative allosteric binding site; other site 1124936006207 PUA domain; Region: PUA; pfam01472 1124936006208 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1124936006209 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1124936006210 putative catalytic cysteine [active] 1124936006211 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1124936006212 Int/Topo IB signature motif; other site 1124936006213 hypothetical protein; Region: PHA00626 1124936006214 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1124936006215 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1124936006216 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1124936006217 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1124936006218 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 1124936006219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1124936006220 ERF superfamily; Region: ERF; pfam04404 1124936006221 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 1124936006222 hypothetical protein; Region: PHA01516 1124936006223 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1124936006224 Antirestriction protein Ral; Region: Ral; pfam11058 1124936006225 Superinfection exclusion protein B; Region: SieB; pfam14163 1124936006226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936006227 sequence-specific DNA binding site [nucleotide binding]; other site 1124936006228 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1124936006229 salt bridge; other site 1124936006230 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124936006231 Catalytic site [active] 1124936006232 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1124936006233 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1124936006234 Protein of unknown function (DUF2740); Region: DUF2740; pfam10872 1124936006235 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1124936006236 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1124936006237 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1124936006238 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1124936006239 Walker A motif; other site 1124936006240 ATP binding site [chemical binding]; other site 1124936006241 Walker B motif; other site 1124936006242 DNA binding loops [nucleotide binding] 1124936006243 NinB protein; Region: NinB; pfam05772 1124936006244 NINE Protein; Region: NinE; pfam05322 1124936006245 hypothetical protein; Region: PHA01519 1124936006246 NinF protein; Region: NinF; pfam05810 1124936006247 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1124936006248 Phage NinH protein; Region: Phage_NinH; pfam06322 1124936006249 Antitermination protein; Region: Antiterm; pfam03589 1124936006250 Antitermination protein; Region: Antiterm; pfam03589 1124936006251 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1124936006252 catalytic residues [active] 1124936006253 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1124936006254 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1124936006255 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1124936006256 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 1124936006257 hypothetical protein; Region: PHA00781 1124936006258 Terminase-like family; Region: Terminase_6; pfam03237 1124936006259 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1124936006260 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 1124936006261 coat protein; Region: PHA01511 1124936006262 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1124936006263 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 1124936006264 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 1124936006265 Protein of unknown function (DUF812); Region: DUF812; pfam05667 1124936006266 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 1124936006267 Arc-like DNA binding domain; Region: Arc; pfam03869 1124936006268 Head binding; Region: Head_binding; pfam09008 1124936006269 Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251 1124936006270 O-antigen conversion protein C; Region: PHA01514 1124936006271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124936006272 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1124936006273 Ligand binding site; other site 1124936006274 Putative Catalytic site; other site 1124936006275 DXD motif; other site 1124936006276 Predicted membrane protein [Function unknown]; Region: COG2246 1124936006277 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1124936006278 Integrase core domain; Region: rve; pfam00665 1124936006279 Integrase core domain; Region: rve_2; pfam13333 1124936006280 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1124936006281 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1124936006282 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124936006283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006284 putative substrate translocation pore; other site 1124936006285 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1124936006286 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1124936006287 substrate binding site [chemical binding]; other site 1124936006288 ligand binding site [chemical binding]; other site 1124936006289 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 1124936006290 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1124936006291 hypothetical protein; Provisional; Region: PRK14812 1124936006292 substrate binding site [chemical binding]; other site 1124936006293 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1124936006294 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1124936006295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124936006296 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124936006297 transcriptional activator TtdR; Provisional; Region: PRK09801 1124936006298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936006299 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1124936006300 putative effector binding pocket; other site 1124936006301 putative dimerization interface [polypeptide binding]; other site 1124936006302 YjzC-like protein; Region: YjzC; pfam14168 1124936006303 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1124936006304 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936006305 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936006306 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 1124936006307 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 1124936006308 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936006309 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936006310 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936006311 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 1124936006312 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936006313 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936006314 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1124936006315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1124936006316 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124936006317 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936006318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1124936006319 DNA binding site [nucleotide binding] 1124936006320 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1124936006321 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1124936006322 DNA binding residues [nucleotide binding] 1124936006323 dimerization interface [polypeptide binding]; other site 1124936006324 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1124936006325 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1124936006326 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1124936006327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124936006328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936006329 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936006330 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1124936006331 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124936006332 metal-binding site [ion binding] 1124936006333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124936006334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936006335 motif II; other site 1124936006336 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1124936006337 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1124936006338 DNA binding residues [nucleotide binding] 1124936006339 dimer interface [polypeptide binding]; other site 1124936006340 copper binding site [ion binding]; other site 1124936006341 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124936006342 metal-binding site [ion binding] 1124936006343 putative sialic acid transporter; Region: 2A0112; TIGR00891 1124936006344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006345 putative substrate translocation pore; other site 1124936006346 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1124936006347 DNA methylase; Region: N6_N4_Mtase; cl17433 1124936006348 DNA methylase; Region: N6_N4_Mtase; pfam01555 1124936006349 potential frameshift: common BLAST hit: gi|194442308|ref|YP_002039596.1| type III restriction-modification system StyLTI enzyme res 1124936006350 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1124936006351 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1124936006352 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1124936006353 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1124936006354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936006355 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1124936006356 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936006357 N-terminal plug; other site 1124936006358 ligand-binding site [chemical binding]; other site 1124936006359 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1124936006360 hypothetical protein; Provisional; Region: PRK09929 1124936006361 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1124936006362 Propionate catabolism activator; Region: PrpR_N; pfam06506 1124936006363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936006364 Walker A motif; other site 1124936006365 ATP binding site [chemical binding]; other site 1124936006366 Walker B motif; other site 1124936006367 arginine finger; other site 1124936006368 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124936006369 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1124936006370 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124936006371 tetramer interface [polypeptide binding]; other site 1124936006372 active site 1124936006373 Mg2+/Mn2+ binding site [ion binding]; other site 1124936006374 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1124936006375 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1124936006376 dimer interface [polypeptide binding]; other site 1124936006377 active site 1124936006378 citrylCoA binding site [chemical binding]; other site 1124936006379 oxalacetate/citrate binding site [chemical binding]; other site 1124936006380 coenzyme A binding site [chemical binding]; other site 1124936006381 catalytic triad [active] 1124936006382 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1124936006383 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1124936006384 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1124936006385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124936006386 acyl-activating enzyme (AAE) consensus motif; other site 1124936006387 AMP binding site [chemical binding]; other site 1124936006388 active site 1124936006389 CoA binding site [chemical binding]; other site 1124936006390 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1124936006391 dimer interface [polypeptide binding]; other site 1124936006392 active site 1124936006393 Schiff base residues; other site 1124936006394 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1124936006395 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1124936006396 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1124936006397 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1124936006398 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124936006399 ligand binding site [chemical binding]; other site 1124936006400 flexible hinge region; other site 1124936006401 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1124936006402 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124936006403 microcin B17 transporter; Reviewed; Region: PRK11098 1124936006404 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1124936006405 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1124936006406 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1124936006407 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1124936006408 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1124936006409 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1124936006410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1124936006411 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1124936006412 drug efflux system protein MdtG; Provisional; Region: PRK09874 1124936006413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006414 putative substrate translocation pore; other site 1124936006415 anti-RssB factor; Provisional; Region: PRK10244 1124936006416 hypothetical protein; Provisional; Region: PRK11505 1124936006417 psiF repeat; Region: PsiF_repeat; pfam07769 1124936006418 psiF repeat; Region: PsiF_repeat; pfam07769 1124936006419 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1124936006420 MASE2 domain; Region: MASE2; pfam05230 1124936006421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936006422 metal binding site [ion binding]; metal-binding site 1124936006423 active site 1124936006424 I-site; other site 1124936006425 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1124936006426 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1124936006427 hypothetical protein; Validated; Region: PRK00124 1124936006428 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1124936006429 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1124936006430 ADP binding site [chemical binding]; other site 1124936006431 magnesium binding site [ion binding]; other site 1124936006432 putative shikimate binding site; other site 1124936006433 hypothetical protein; Provisional; Region: PRK10380 1124936006434 hypothetical protein; Provisional; Region: PRK10481 1124936006435 hypothetical protein; Provisional; Region: PRK10579 1124936006436 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1124936006437 fructokinase; Reviewed; Region: PRK09557 1124936006438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936006439 nucleotide binding site [chemical binding]; other site 1124936006440 MFS transport protein AraJ; Provisional; Region: PRK10091 1124936006441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006442 putative substrate translocation pore; other site 1124936006443 exonuclease subunit SbcC; Provisional; Region: PRK10246 1124936006444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936006445 Walker A/P-loop; other site 1124936006446 ATP binding site [chemical binding]; other site 1124936006447 Q-loop/lid; other site 1124936006448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936006449 ABC transporter signature motif; other site 1124936006450 Walker B; other site 1124936006451 D-loop; other site 1124936006452 H-loop/switch region; other site 1124936006453 exonuclease subunit SbcD; Provisional; Region: PRK10966 1124936006454 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1124936006455 active site 1124936006456 metal binding site [ion binding]; metal-binding site 1124936006457 DNA binding site [nucleotide binding] 1124936006458 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1124936006459 transcriptional regulator PhoB; Provisional; Region: PRK10161 1124936006460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936006461 active site 1124936006462 phosphorylation site [posttranslational modification] 1124936006463 intermolecular recognition site; other site 1124936006464 dimerization interface [polypeptide binding]; other site 1124936006465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936006466 DNA binding site [nucleotide binding] 1124936006467 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1124936006468 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1124936006469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936006470 putative active site [active] 1124936006471 heme pocket [chemical binding]; other site 1124936006472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936006473 dimer interface [polypeptide binding]; other site 1124936006474 phosphorylation site [posttranslational modification] 1124936006475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936006476 ATP binding site [chemical binding]; other site 1124936006477 Mg2+ binding site [ion binding]; other site 1124936006478 G-X-G motif; other site 1124936006479 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1124936006480 putative proline-specific permease; Provisional; Region: proY; PRK10580 1124936006481 maltodextrin glucosidase; Provisional; Region: PRK10785 1124936006482 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1124936006483 homodimer interface [polypeptide binding]; other site 1124936006484 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1124936006485 active site 1124936006486 homodimer interface [polypeptide binding]; other site 1124936006487 catalytic site [active] 1124936006488 peroxidase; Provisional; Region: PRK15000 1124936006489 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1124936006490 dimer interface [polypeptide binding]; other site 1124936006491 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1124936006492 catalytic triad [active] 1124936006493 peroxidatic and resolving cysteines [active] 1124936006494 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1124936006495 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1124936006496 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1124936006497 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1124936006498 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1124936006499 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1124936006500 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1124936006501 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1124936006502 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1124936006503 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1124936006504 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1124936006505 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1124936006506 Protein export membrane protein; Region: SecD_SecF; pfam02355 1124936006507 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1124936006508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124936006509 Predicted transcriptional regulator [Transcription]; Region: COG2378 1124936006510 HTH domain; Region: HTH_11; pfam08279 1124936006511 WYL domain; Region: WYL; pfam13280 1124936006512 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1124936006513 active site 1124936006514 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1124936006515 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1124936006516 hypothetical protein; Provisional; Region: PRK11530 1124936006517 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1124936006518 ATP cone domain; Region: ATP-cone; pfam03477 1124936006519 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1124936006520 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1124936006521 catalytic motif [active] 1124936006522 Zn binding site [ion binding]; other site 1124936006523 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1124936006524 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1124936006525 homopentamer interface [polypeptide binding]; other site 1124936006526 active site 1124936006527 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1124936006528 putative RNA binding site [nucleotide binding]; other site 1124936006529 thiamine monophosphate kinase; Provisional; Region: PRK05731 1124936006530 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1124936006531 ATP binding site [chemical binding]; other site 1124936006532 dimerization interface [polypeptide binding]; other site 1124936006533 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1124936006534 tetramer interfaces [polypeptide binding]; other site 1124936006535 binuclear metal-binding site [ion binding]; other site 1124936006536 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936006537 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936006538 active site 1124936006539 catalytic tetrad [active] 1124936006540 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1124936006541 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1124936006542 TPP-binding site; other site 1124936006543 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1124936006544 PYR/PP interface [polypeptide binding]; other site 1124936006545 dimer interface [polypeptide binding]; other site 1124936006546 TPP binding site [chemical binding]; other site 1124936006547 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124936006548 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1124936006549 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1124936006550 substrate binding pocket [chemical binding]; other site 1124936006551 chain length determination region; other site 1124936006552 substrate-Mg2+ binding site; other site 1124936006553 catalytic residues [active] 1124936006554 aspartate-rich region 1; other site 1124936006555 active site lid residues [active] 1124936006556 aspartate-rich region 2; other site 1124936006557 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1124936006558 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1124936006559 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1124936006560 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1124936006561 Ligand Binding Site [chemical binding]; other site 1124936006562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1124936006563 active site residue [active] 1124936006564 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124936006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936006566 dimer interface [polypeptide binding]; other site 1124936006567 conserved gate region; other site 1124936006568 putative PBP binding loops; other site 1124936006569 ABC-ATPase subunit interface; other site 1124936006570 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1124936006571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936006572 dimer interface [polypeptide binding]; other site 1124936006573 conserved gate region; other site 1124936006574 putative PBP binding loops; other site 1124936006575 ABC-ATPase subunit interface; other site 1124936006576 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1124936006577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936006578 Walker A/P-loop; other site 1124936006579 ATP binding site [chemical binding]; other site 1124936006580 Q-loop/lid; other site 1124936006581 ABC transporter signature motif; other site 1124936006582 Walker B; other site 1124936006583 D-loop; other site 1124936006584 H-loop/switch region; other site 1124936006585 TOBE domain; Region: TOBE_2; pfam08402 1124936006586 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1124936006587 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124936006588 transcriptional regulator protein; Region: phnR; TIGR03337 1124936006589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936006590 DNA-binding site [nucleotide binding]; DNA binding site 1124936006591 UTRA domain; Region: UTRA; pfam07702 1124936006592 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 1124936006593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936006594 catalytic residue [active] 1124936006595 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1124936006596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936006597 motif II; other site 1124936006598 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1124936006599 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1124936006600 conserved cys residue [active] 1124936006601 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1124936006602 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1124936006603 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1124936006604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1124936006605 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1124936006606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936006608 putative substrate translocation pore; other site 1124936006609 Sel1-like repeats; Region: SEL1; smart00671 1124936006610 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936006611 Sel1 repeat; Region: Sel1; pfam08238 1124936006612 Sel1-like repeats; Region: SEL1; smart00671 1124936006613 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936006614 Sel1-like repeats; Region: SEL1; smart00671 1124936006615 Sel1-like repeats; Region: SEL1; smart00671 1124936006616 Sel1-like repeats; Region: SEL1; smart00671 1124936006617 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1124936006618 UbiA prenyltransferase family; Region: UbiA; pfam01040 1124936006619 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1124936006620 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1124936006621 Subunit I/III interface [polypeptide binding]; other site 1124936006622 Subunit III/IV interface [polypeptide binding]; other site 1124936006623 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1124936006624 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1124936006625 D-pathway; other site 1124936006626 Putative ubiquinol binding site [chemical binding]; other site 1124936006627 Low-spin heme (heme b) binding site [chemical binding]; other site 1124936006628 Putative water exit pathway; other site 1124936006629 Binuclear center (heme o3/CuB) [ion binding]; other site 1124936006630 K-pathway; other site 1124936006631 Putative proton exit pathway; other site 1124936006632 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1124936006633 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1124936006634 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1124936006635 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1124936006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006637 putative substrate translocation pore; other site 1124936006638 hypothetical protein; Provisional; Region: PRK11627 1124936006639 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1124936006640 transcriptional regulator BolA; Provisional; Region: PRK11628 1124936006641 trigger factor; Provisional; Region: tig; PRK01490 1124936006642 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124936006643 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1124936006644 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1124936006645 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1124936006646 oligomer interface [polypeptide binding]; other site 1124936006647 active site residues [active] 1124936006648 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1124936006649 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1124936006650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936006651 Walker A motif; other site 1124936006652 ATP binding site [chemical binding]; other site 1124936006653 Walker B motif; other site 1124936006654 Iron permease FTR1 family; Region: FTR1; cl00475 1124936006655 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124936006656 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1124936006657 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1124936006658 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1124936006659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936006660 Walker A motif; other site 1124936006661 ATP binding site [chemical binding]; other site 1124936006662 Walker B motif; other site 1124936006663 arginine finger; other site 1124936006664 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1124936006665 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124936006666 IHF dimer interface [polypeptide binding]; other site 1124936006667 IHF - DNA interface [nucleotide binding]; other site 1124936006668 periplasmic folding chaperone; Provisional; Region: PRK10788 1124936006669 SurA N-terminal domain; Region: SurA_N_3; cl07813 1124936006670 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1124936006671 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1124936006672 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124936006673 active site 1124936006674 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1124936006675 Ligand Binding Site [chemical binding]; other site 1124936006676 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1124936006677 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1124936006678 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1124936006679 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1124936006680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936006681 active site 1124936006682 motif I; other site 1124936006683 motif II; other site 1124936006684 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1124936006685 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1124936006686 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936006687 catalytic residue [active] 1124936006688 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124936006689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936006690 putative DNA binding site [nucleotide binding]; other site 1124936006691 putative Zn2+ binding site [ion binding]; other site 1124936006692 AsnC family; Region: AsnC_trans_reg; pfam01037 1124936006693 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1124936006694 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936006695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936006696 Walker A/P-loop; other site 1124936006697 ATP binding site [chemical binding]; other site 1124936006698 Q-loop/lid; other site 1124936006699 ABC transporter signature motif; other site 1124936006700 Walker B; other site 1124936006701 D-loop; other site 1124936006702 H-loop/switch region; other site 1124936006703 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1124936006704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936006705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936006706 Walker A/P-loop; other site 1124936006707 ATP binding site [chemical binding]; other site 1124936006708 Q-loop/lid; other site 1124936006709 ABC transporter signature motif; other site 1124936006710 Walker B; other site 1124936006711 D-loop; other site 1124936006712 H-loop/switch region; other site 1124936006713 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1124936006714 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1124936006715 ammonium transporter; Provisional; Region: PRK10666 1124936006716 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1124936006717 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1124936006718 active site 1124936006719 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1124936006720 catalytic triad [active] 1124936006721 dimer interface [polypeptide binding]; other site 1124936006722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1124936006723 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1124936006724 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124936006725 DNA binding site [nucleotide binding] 1124936006726 active site 1124936006727 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1124936006728 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124936006729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936006730 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1124936006731 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1124936006732 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1124936006733 maltose O-acetyltransferase; Provisional; Region: PRK10092 1124936006734 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1124936006735 active site 1124936006736 substrate binding site [chemical binding]; other site 1124936006737 trimer interface [polypeptide binding]; other site 1124936006738 CoA binding site [chemical binding]; other site 1124936006739 gene expression modulator; Provisional; Region: PRK10945 1124936006740 Hha toxicity attenuator; Provisional; Region: PRK10667 1124936006741 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1124936006742 Protein export membrane protein; Region: SecD_SecF; cl14618 1124936006743 Protein export membrane protein; Region: SecD_SecF; cl14618 1124936006744 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1124936006745 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936006746 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1124936006747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936006748 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1124936006749 hypothetical protein; Provisional; Region: PRK11281 1124936006750 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1124936006751 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1124936006752 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936006753 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1124936006754 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1124936006755 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1124936006756 hypothetical protein; Provisional; Region: PRK11038 1124936006757 primosomal replication protein N''; Provisional; Region: PRK10093 1124936006758 hypothetical protein; Provisional; Region: PRK10527 1124936006759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936006760 active site 1124936006761 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1124936006762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936006763 Walker A motif; other site 1124936006764 ATP binding site [chemical binding]; other site 1124936006765 Walker B motif; other site 1124936006766 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1124936006767 arginine finger; other site 1124936006768 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1124936006769 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1124936006770 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1124936006771 hypothetical protein; Validated; Region: PRK00153 1124936006772 recombination protein RecR; Reviewed; Region: recR; PRK00076 1124936006773 RecR protein; Region: RecR; pfam02132 1124936006774 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1124936006775 putative active site [active] 1124936006776 putative metal-binding site [ion binding]; other site 1124936006777 tetramer interface [polypeptide binding]; other site 1124936006778 heat shock protein 90; Provisional; Region: PRK05218 1124936006779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936006780 ATP binding site [chemical binding]; other site 1124936006781 Mg2+ binding site [ion binding]; other site 1124936006782 G-X-G motif; other site 1124936006783 adenylate kinase; Reviewed; Region: adk; PRK00279 1124936006784 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1124936006785 AMP-binding site [chemical binding]; other site 1124936006786 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1124936006787 ferrochelatase; Reviewed; Region: hemH; PRK00035 1124936006788 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1124936006789 C-terminal domain interface [polypeptide binding]; other site 1124936006790 active site 1124936006791 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1124936006792 active site 1124936006793 N-terminal domain interface [polypeptide binding]; other site 1124936006794 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1124936006795 acetyl esterase; Provisional; Region: PRK10162 1124936006796 inosine/guanosine kinase; Provisional; Region: PRK15074 1124936006797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936006798 putative cation:proton antiport protein; Provisional; Region: PRK10669 1124936006799 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1124936006800 TrkA-N domain; Region: TrkA_N; pfam02254 1124936006801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936006803 putative substrate translocation pore; other site 1124936006804 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1124936006805 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1124936006806 active site 1124936006807 metal binding site [ion binding]; metal-binding site 1124936006808 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1124936006809 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1124936006810 putative deacylase active site [active] 1124936006811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1124936006812 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1124936006813 copper exporting ATPase; Provisional; Region: copA; PRK10671 1124936006814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124936006815 metal-binding site [ion binding] 1124936006816 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124936006817 metal-binding site [ion binding] 1124936006818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124936006819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936006820 motif II; other site 1124936006821 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1124936006822 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1124936006823 DNA binding residues [nucleotide binding] 1124936006824 dimer interface [polypeptide binding]; other site 1124936006825 copper binding site [ion binding]; other site 1124936006826 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1124936006827 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1124936006828 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1124936006829 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1124936006830 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1124936006831 Walker A/P-loop; other site 1124936006832 ATP binding site [chemical binding]; other site 1124936006833 Q-loop/lid; other site 1124936006834 ABC transporter signature motif; other site 1124936006835 Walker B; other site 1124936006836 D-loop; other site 1124936006837 H-loop/switch region; other site 1124936006838 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1124936006839 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1124936006840 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1124936006841 oxidoreductase; Provisional; Region: PRK08017 1124936006842 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1124936006843 NADP binding site [chemical binding]; other site 1124936006844 active site 1124936006845 steroid binding site; other site 1124936006846 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1124936006847 active site 1124936006848 catalytic triad [active] 1124936006849 oxyanion hole [active] 1124936006850 switch loop; other site 1124936006851 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1124936006852 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124936006853 Walker A/P-loop; other site 1124936006854 ATP binding site [chemical binding]; other site 1124936006855 Q-loop/lid; other site 1124936006856 ABC transporter signature motif; other site 1124936006857 Walker B; other site 1124936006858 D-loop; other site 1124936006859 H-loop/switch region; other site 1124936006860 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1124936006861 FtsX-like permease family; Region: FtsX; pfam02687 1124936006862 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936006863 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124936006864 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1124936006865 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1124936006866 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1124936006867 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1124936006868 Walker A/P-loop; other site 1124936006869 ATP binding site [chemical binding]; other site 1124936006870 Q-loop/lid; other site 1124936006871 ABC transporter signature motif; other site 1124936006872 Walker B; other site 1124936006873 D-loop; other site 1124936006874 H-loop/switch region; other site 1124936006875 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1124936006876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936006877 dimer interface [polypeptide binding]; other site 1124936006878 conserved gate region; other site 1124936006879 ABC-ATPase subunit interface; other site 1124936006880 Predicted ATPase [General function prediction only]; Region: COG2603 1124936006881 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1124936006882 active site residue [active] 1124936006883 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1124936006884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936006885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936006886 dimerization interface [polypeptide binding]; other site 1124936006887 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1124936006888 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1124936006889 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1124936006890 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124936006891 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124936006892 glyoxylate carboligase; Provisional; Region: PRK11269 1124936006893 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124936006894 PYR/PP interface [polypeptide binding]; other site 1124936006895 dimer interface [polypeptide binding]; other site 1124936006896 TPP binding site [chemical binding]; other site 1124936006897 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124936006898 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1124936006899 TPP-binding site [chemical binding]; other site 1124936006900 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1124936006901 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1124936006902 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124936006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936006904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936006905 putative substrate translocation pore; other site 1124936006906 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1124936006907 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124936006908 Na binding site [ion binding]; other site 1124936006909 putative substrate binding site [chemical binding]; other site 1124936006910 allantoinase; Provisional; Region: PRK08044 1124936006911 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1124936006912 active site 1124936006913 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1124936006914 glycerate kinase II; Provisional; Region: PRK09932 1124936006915 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1124936006916 Mif2/CENP-C like; Region: Mif2; pfam11699 1124936006917 Cupin domain; Region: Cupin_2; pfam07883 1124936006918 allantoate amidohydrolase; Region: AllC; TIGR03176 1124936006919 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1124936006920 active site 1124936006921 metal binding site [ion binding]; metal-binding site 1124936006922 dimer interface [polypeptide binding]; other site 1124936006923 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1124936006924 membrane protein FdrA; Validated; Region: PRK06091 1124936006925 CoA binding domain; Region: CoA_binding; pfam02629 1124936006926 CoA-ligase; Region: Ligase_CoA; pfam00549 1124936006927 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1124936006928 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1124936006929 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1124936006930 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1124936006931 putative substrate binding site [chemical binding]; other site 1124936006932 nucleotide binding site [chemical binding]; other site 1124936006933 nucleotide binding site [chemical binding]; other site 1124936006934 homodimer interface [polypeptide binding]; other site 1124936006935 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1124936006936 ATP-grasp domain; Region: ATP-grasp; pfam02222 1124936006937 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1124936006938 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1124936006939 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124936006940 putative active site [active] 1124936006941 putative metal binding site [ion binding]; other site 1124936006942 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1124936006943 substrate binding site [chemical binding]; other site 1124936006944 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1124936006945 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1124936006946 active site 1124936006947 HIGH motif; other site 1124936006948 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1124936006949 KMSKS motif; other site 1124936006950 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1124936006951 tRNA binding surface [nucleotide binding]; other site 1124936006952 anticodon binding site; other site 1124936006953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 1124936006954 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 1124936006955 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1124936006956 ribosome-associated protein; Provisional; Region: PRK11507 1124936006957 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1124936006958 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1124936006959 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1124936006960 homodimer interface [polypeptide binding]; other site 1124936006961 NADP binding site [chemical binding]; other site 1124936006962 substrate binding site [chemical binding]; other site 1124936006963 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1124936006964 fimbrial protein FimI; Provisional; Region: PRK15200 1124936006965 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1124936006966 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936006967 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936006968 outer membrane usher protein FimD; Provisional; Region: PRK15198 1124936006969 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936006970 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936006971 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936006972 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1124936006973 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1124936006974 transcriptional regulator FimZ; Provisional; Region: PRK09935 1124936006975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936006976 active site 1124936006977 phosphorylation site [posttranslational modification] 1124936006978 intermolecular recognition site; other site 1124936006979 dimerization interface [polypeptide binding]; other site 1124936006980 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936006981 DNA binding residues [nucleotide binding] 1124936006982 dimerization interface [polypeptide binding]; other site 1124936006983 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 1124936006984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936006985 DNA binding residues [nucleotide binding] 1124936006986 dimerization interface [polypeptide binding]; other site 1124936006987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936006988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1124936006989 Transposase; Region: HTH_Tnp_1; pfam01527 1124936006990 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124936006991 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1124936006992 Ligand binding site; other site 1124936006993 Putative Catalytic site; other site 1124936006994 DXD motif; other site 1124936006995 Predicted membrane protein [Function unknown]; Region: COG2246 1124936006996 GtrA-like protein; Region: GtrA; pfam04138 1124936006997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936006998 ATP binding site [chemical binding]; other site 1124936006999 Mg2+ binding site [ion binding]; other site 1124936007000 G-X-G motif; other site 1124936007001 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1124936007002 Cupin; Region: Cupin_6; pfam12852 1124936007003 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124936007004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936007005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936007006 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1124936007007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936007008 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124936007009 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936007010 Predicted membrane protein [Function unknown]; Region: COG3059 1124936007011 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1124936007012 phenylalanine transporter; Provisional; Region: PRK10249 1124936007013 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124936007014 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936007015 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1124936007016 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1124936007017 active site 1124936007018 oxyanion hole [active] 1124936007019 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1124936007020 catalytic triad [active] 1124936007021 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1124936007022 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1124936007023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936007024 ATP binding site [chemical binding]; other site 1124936007025 Walker B motif; other site 1124936007026 arginine finger; other site 1124936007027 Transcriptional antiterminator [Transcription]; Region: COG3933 1124936007028 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936007029 active pocket/dimerization site; other site 1124936007030 active site 1124936007031 phosphorylation site [posttranslational modification] 1124936007032 PRD domain; Region: PRD; pfam00874 1124936007033 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1124936007034 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1124936007035 putative active site [active] 1124936007036 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124936007037 dimer interface [polypeptide binding]; other site 1124936007038 active site 1124936007039 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1124936007040 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1124936007041 dimer interface [polypeptide binding]; other site 1124936007042 active site 1124936007043 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124936007044 dimer interface [polypeptide binding]; other site 1124936007045 active site 1124936007046 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1124936007047 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1124936007048 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1124936007049 active site 1124936007050 phosphorylation site [posttranslational modification] 1124936007051 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936007052 active pocket/dimerization site; other site 1124936007053 active site 1124936007054 phosphorylation site [posttranslational modification] 1124936007055 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1124936007056 dimer interface [polypeptide binding]; other site 1124936007057 FMN binding site [chemical binding]; other site 1124936007058 hypothetical protein; Provisional; Region: PRK10250 1124936007059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124936007060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936007061 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1124936007062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936007063 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1124936007064 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1124936007065 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1124936007066 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1124936007067 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1124936007068 outer membrane receptor FepA; Provisional; Region: PRK13524 1124936007069 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936007070 N-terminal plug; other site 1124936007071 ligand-binding site [chemical binding]; other site 1124936007072 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1124936007073 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1124936007074 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1124936007075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1124936007076 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1124936007077 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124936007078 acyl-activating enzyme (AAE) consensus motif; other site 1124936007079 AMP binding site [chemical binding]; other site 1124936007080 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124936007081 LPS O-antigen length regulator; Provisional; Region: PRK10381 1124936007082 Chain length determinant protein; Region: Wzz; pfam02706 1124936007083 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1124936007084 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124936007085 Walker A/P-loop; other site 1124936007086 ATP binding site [chemical binding]; other site 1124936007087 Q-loop/lid; other site 1124936007088 ABC transporter signature motif; other site 1124936007089 Walker B; other site 1124936007090 D-loop; other site 1124936007091 H-loop/switch region; other site 1124936007092 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1124936007093 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936007094 ABC-ATPase subunit interface; other site 1124936007095 dimer interface [polypeptide binding]; other site 1124936007096 putative PBP binding regions; other site 1124936007097 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124936007098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936007099 ABC-ATPase subunit interface; other site 1124936007100 dimer interface [polypeptide binding]; other site 1124936007101 putative PBP binding regions; other site 1124936007102 enterobactin exporter EntS; Provisional; Region: PRK10489 1124936007103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936007104 putative substrate translocation pore; other site 1124936007105 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1124936007106 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1124936007107 siderophore binding site; other site 1124936007108 isochorismate synthase EntC; Provisional; Region: PRK15016 1124936007109 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1124936007110 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1124936007111 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1124936007112 acyl-activating enzyme (AAE) consensus motif; other site 1124936007113 active site 1124936007114 AMP binding site [chemical binding]; other site 1124936007115 substrate binding site [chemical binding]; other site 1124936007116 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1124936007117 hydrophobic substrate binding pocket; other site 1124936007118 Isochorismatase family; Region: Isochorismatase; pfam00857 1124936007119 active site 1124936007120 conserved cis-peptide bond; other site 1124936007121 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1124936007122 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1124936007123 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1124936007124 putative NAD(P) binding site [chemical binding]; other site 1124936007125 active site 1124936007126 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124936007127 CoenzymeA binding site [chemical binding]; other site 1124936007128 subunit interaction site [polypeptide binding]; other site 1124936007129 PHB binding site; other site 1124936007130 carbon starvation protein A; Provisional; Region: PRK15015 1124936007131 Carbon starvation protein CstA; Region: CstA; pfam02554 1124936007132 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1124936007133 Uncharacterized small protein [Function unknown]; Region: COG2879 1124936007134 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1124936007135 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1124936007136 putative active site [active] 1124936007137 metal binding site [ion binding]; metal-binding site 1124936007138 methionine aminotransferase; Validated; Region: PRK09082 1124936007139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936007140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936007141 homodimer interface [polypeptide binding]; other site 1124936007142 catalytic residue [active] 1124936007143 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1124936007144 ParB-like nuclease domain; Region: ParBc; pfam02195 1124936007145 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1124936007146 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1124936007147 Active Sites [active] 1124936007148 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1124936007149 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1124936007150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936007151 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936007152 dimerization interface [polypeptide binding]; other site 1124936007153 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1124936007154 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1124936007155 dimerization domain [polypeptide binding]; other site 1124936007156 dimer interface [polypeptide binding]; other site 1124936007157 catalytic residues [active] 1124936007158 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1124936007159 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1124936007160 dimer interface [polypeptide binding]; other site 1124936007161 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1124936007162 catalytic triad [active] 1124936007163 peroxidatic and resolving cysteines [active] 1124936007164 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1124936007165 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1124936007166 catalytic residue [active] 1124936007167 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1124936007168 catalytic residues [active] 1124936007169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936007170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936007171 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1124936007172 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1124936007173 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1124936007174 putative [4Fe-4S] binding site [ion binding]; other site 1124936007175 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936007176 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1124936007177 molybdopterin cofactor binding site; other site 1124936007178 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1124936007179 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1124936007180 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1124936007181 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124936007182 Ligand Binding Site [chemical binding]; other site 1124936007183 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1124936007184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1124936007185 NAD binding site [chemical binding]; other site 1124936007186 catalytic Zn binding site [ion binding]; other site 1124936007187 structural Zn binding site [ion binding]; other site 1124936007188 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1124936007189 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124936007190 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1124936007191 B1 nucleotide binding pocket [chemical binding]; other site 1124936007192 B2 nucleotide binding pocket [chemical binding]; other site 1124936007193 CAS motifs; other site 1124936007194 active site 1124936007195 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1124936007196 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1124936007197 transmembrane helices; other site 1124936007198 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1124936007199 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1124936007200 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1124936007201 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1124936007202 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1124936007203 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1124936007204 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1124936007205 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1124936007206 putative active site [active] 1124936007207 (T/H)XGH motif; other site 1124936007208 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1124936007209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936007210 putative active site [active] 1124936007211 heme pocket [chemical binding]; other site 1124936007212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936007213 ATP binding site [chemical binding]; other site 1124936007214 Mg2+ binding site [ion binding]; other site 1124936007215 G-X-G motif; other site 1124936007216 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1124936007217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936007218 active site 1124936007219 phosphorylation site [posttranslational modification] 1124936007220 intermolecular recognition site; other site 1124936007221 dimerization interface [polypeptide binding]; other site 1124936007222 Transcriptional regulator; Region: CitT; pfam12431 1124936007223 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1124936007224 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1124936007225 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1124936007226 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124936007227 DNA-binding site [nucleotide binding]; DNA binding site 1124936007228 RNA-binding motif; other site 1124936007229 chromosome condensation membrane protein; Provisional; Region: PRK14196 1124936007230 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124936007231 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1124936007232 putative active site [active] 1124936007233 catalytic triad [active] 1124936007234 putative dimer interface [polypeptide binding]; other site 1124936007235 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1124936007236 lipoyl synthase; Provisional; Region: PRK05481 1124936007237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936007238 FeS/SAM binding site; other site 1124936007239 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1124936007240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936007241 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124936007242 substrate binding pocket [chemical binding]; other site 1124936007243 dimerization interface [polypeptide binding]; other site 1124936007244 lipoate-protein ligase B; Provisional; Region: PRK14342 1124936007245 hypothetical protein; Provisional; Region: PRK04998 1124936007246 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1124936007247 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1124936007248 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1124936007249 rare lipoprotein A; Provisional; Region: PRK10672 1124936007250 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1124936007251 Sporulation related domain; Region: SPOR; pfam05036 1124936007252 cell wall shape-determining protein; Provisional; Region: PRK10794 1124936007253 penicillin-binding protein 2; Provisional; Region: PRK10795 1124936007254 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124936007255 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124936007256 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1124936007257 ribosome-associated protein; Provisional; Region: PRK11538 1124936007258 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124936007259 catalytic core [active] 1124936007260 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1124936007261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936007262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936007263 homodimer interface [polypeptide binding]; other site 1124936007264 catalytic residue [active] 1124936007265 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1124936007266 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1124936007267 active site 1124936007268 (T/H)XGH motif; other site 1124936007269 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1124936007270 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1124936007271 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1124936007272 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1124936007273 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1124936007274 HIGH motif; other site 1124936007275 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1124936007276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124936007277 active site 1124936007278 KMSKS motif; other site 1124936007279 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1124936007280 tRNA binding surface [nucleotide binding]; other site 1124936007281 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1124936007282 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1124936007283 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1124936007284 Propionate catabolism activator; Region: PrpR_N; pfam06506 1124936007285 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1124936007286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936007287 Walker A motif; other site 1124936007288 ATP binding site [chemical binding]; other site 1124936007289 Walker B motif; other site 1124936007290 arginine finger; other site 1124936007291 hypothetical protein; Provisional; Region: PRK11032 1124936007292 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1124936007293 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936007294 Sel1-like repeats; Region: SEL1; smart00671 1124936007295 Sel1-like repeats; Region: SEL1; smart00671 1124936007296 Sel1-like repeats; Region: SEL1; smart00671 1124936007297 Sel1-like repeats; Region: SEL1; smart00671 1124936007298 Sel1-like repeats; Region: SEL1; smart00671 1124936007299 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1124936007300 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1124936007301 HSP70 interaction site [polypeptide binding]; other site 1124936007302 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1124936007303 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1124936007304 HSP70 interaction site [polypeptide binding]; other site 1124936007305 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1124936007306 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1124936007307 nucleotide binding site [chemical binding]; other site 1124936007308 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1124936007309 SBD interface [polypeptide binding]; other site 1124936007310 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1124936007311 active site 1124936007312 tetramer interface [polypeptide binding]; other site 1124936007313 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124936007314 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124936007315 Walker A/P-loop; other site 1124936007316 ATP binding site [chemical binding]; other site 1124936007317 Q-loop/lid; other site 1124936007318 ABC transporter signature motif; other site 1124936007319 Walker B; other site 1124936007320 D-loop; other site 1124936007321 H-loop/switch region; other site 1124936007322 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936007323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936007324 dimer interface [polypeptide binding]; other site 1124936007325 conserved gate region; other site 1124936007326 putative PBP binding loops; other site 1124936007327 ABC-ATPase subunit interface; other site 1124936007328 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936007329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936007330 dimer interface [polypeptide binding]; other site 1124936007331 conserved gate region; other site 1124936007332 putative PBP binding loops; other site 1124936007333 ABC-ATPase subunit interface; other site 1124936007334 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1124936007335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936007336 substrate binding pocket [chemical binding]; other site 1124936007337 membrane-bound complex binding site; other site 1124936007338 hinge residues; other site 1124936007339 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1124936007340 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1124936007341 putative active site [active] 1124936007342 catalytic triad [active] 1124936007343 putative dimer interface [polypeptide binding]; other site 1124936007344 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1124936007345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124936007346 Transporter associated domain; Region: CorC_HlyC; smart01091 1124936007347 metal-binding heat shock protein; Provisional; Region: PRK00016 1124936007348 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1124936007349 PhoH-like protein; Region: PhoH; pfam02562 1124936007350 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1124936007351 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1124936007352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936007353 FeS/SAM binding site; other site 1124936007354 TRAM domain; Region: TRAM; pfam01938 1124936007355 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1124936007356 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124936007357 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1124936007358 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1124936007359 active site 1124936007360 dimer interface [polypeptide binding]; other site 1124936007361 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1124936007362 Ligand Binding Site [chemical binding]; other site 1124936007363 Molecular Tunnel; other site 1124936007364 UMP phosphatase; Provisional; Region: PRK10444 1124936007365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007366 active site 1124936007367 motif I; other site 1124936007368 motif II; other site 1124936007369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007370 MarR family; Region: MarR; pfam01047 1124936007371 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1124936007372 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936007373 nucleotide binding site [chemical binding]; other site 1124936007374 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1124936007375 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1124936007376 active site 1124936007377 dimer interface [polypeptide binding]; other site 1124936007378 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1124936007379 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1124936007380 active site 1124936007381 trimer interface [polypeptide binding]; other site 1124936007382 allosteric site; other site 1124936007383 active site lid [active] 1124936007384 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1124936007385 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1124936007386 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124936007387 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124936007388 active site turn [active] 1124936007389 phosphorylation site [posttranslational modification] 1124936007390 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1124936007391 HPr interaction site; other site 1124936007392 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1124936007393 active site 1124936007394 phosphorylation site [posttranslational modification] 1124936007395 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1124936007396 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124936007397 active site 1124936007398 HIGH motif; other site 1124936007399 nucleotide binding site [chemical binding]; other site 1124936007400 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1124936007401 KMSKS motif; other site 1124936007402 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1124936007403 outer membrane porin, OprD family; Region: OprD; pfam03573 1124936007404 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1124936007405 YbfN-like lipoprotein; Region: YbfN; pfam13982 1124936007406 citrate-proton symporter; Provisional; Region: PRK15075 1124936007407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936007408 putative substrate translocation pore; other site 1124936007409 tricarballylate utilization protein B; Provisional; Region: PRK15033 1124936007410 tricarballylate dehydrogenase; Validated; Region: PRK08274 1124936007411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936007412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936007413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936007414 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1124936007415 putative dimerization interface [polypeptide binding]; other site 1124936007416 ferric uptake regulator; Provisional; Region: fur; PRK09462 1124936007417 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1124936007418 metal binding site 2 [ion binding]; metal-binding site 1124936007419 putative DNA binding helix; other site 1124936007420 metal binding site 1 [ion binding]; metal-binding site 1124936007421 dimer interface [polypeptide binding]; other site 1124936007422 structural Zn2+ binding site [ion binding]; other site 1124936007423 flavodoxin FldA; Validated; Region: PRK09267 1124936007424 LexA regulated protein; Provisional; Region: PRK11675 1124936007425 acyl-CoA esterase; Provisional; Region: PRK10673 1124936007426 PGAP1-like protein; Region: PGAP1; pfam07819 1124936007427 replication initiation regulator SeqA; Provisional; Region: PRK11187 1124936007428 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1124936007429 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1124936007430 active site 1124936007431 substrate binding site [chemical binding]; other site 1124936007432 metal binding site [ion binding]; metal-binding site 1124936007433 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1124936007434 putrescine transporter; Provisional; Region: potE; PRK10655 1124936007435 ornithine decarboxylase; Provisional; Region: PRK13578 1124936007436 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1124936007437 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1124936007438 homodimer interface [polypeptide binding]; other site 1124936007439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936007440 catalytic residue [active] 1124936007441 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1124936007442 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1124936007443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936007444 active site 1124936007445 phosphorylation site [posttranslational modification] 1124936007446 intermolecular recognition site; other site 1124936007447 dimerization interface [polypeptide binding]; other site 1124936007448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936007449 DNA binding site [nucleotide binding] 1124936007450 sensor protein KdpD; Provisional; Region: PRK10490 1124936007451 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1124936007452 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1124936007453 Ligand Binding Site [chemical binding]; other site 1124936007454 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1124936007455 GAF domain; Region: GAF_3; pfam13492 1124936007456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936007457 dimer interface [polypeptide binding]; other site 1124936007458 phosphorylation site [posttranslational modification] 1124936007459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936007460 ATP binding site [chemical binding]; other site 1124936007461 Mg2+ binding site [ion binding]; other site 1124936007462 G-X-G motif; other site 1124936007463 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1124936007464 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1124936007465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124936007466 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1124936007467 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1124936007468 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1124936007469 DNA photolyase; Region: DNA_photolyase; pfam00875 1124936007470 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1124936007471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936007472 putative substrate translocation pore; other site 1124936007473 POT family; Region: PTR2; pfam00854 1124936007474 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1124936007475 metal-binding protein; Provisional; Region: PRK10799 1124936007476 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1124936007477 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1124936007478 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1124936007479 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1124936007480 putative active site [active] 1124936007481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936007482 active site 1124936007483 DNA binding site [nucleotide binding] 1124936007484 Int/Topo IB signature motif; other site 1124936007485 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1124936007486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124936007487 UDP-galactopyranose mutase; Region: GLF; pfam03275 1124936007488 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1124936007489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936007490 active site 1124936007491 potential frameshift: common BLAST hit: gi|409249161|ref|YP_006884996.1| Amylovoran biosynthesis glycosyltransferase amsK 1124936007492 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1124936007493 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124936007494 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1124936007495 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1124936007496 Walker A/P-loop; other site 1124936007497 ATP binding site [chemical binding]; other site 1124936007498 Q-loop/lid; other site 1124936007499 ABC transporter signature motif; other site 1124936007500 Walker B; other site 1124936007501 D-loop; other site 1124936007502 H-loop/switch region; other site 1124936007503 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1124936007504 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936007505 active site 1124936007506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1124936007507 active site 1124936007508 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1124936007509 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1124936007510 endonuclease VIII; Provisional; Region: PRK10445 1124936007511 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1124936007512 DNA binding site [nucleotide binding] 1124936007513 catalytic residue [active] 1124936007514 putative catalytic residues [active] 1124936007515 H2TH interface [polypeptide binding]; other site 1124936007516 intercalation triad [nucleotide binding]; other site 1124936007517 substrate specificity determining residue; other site 1124936007518 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1124936007519 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1124936007520 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1124936007521 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1124936007522 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1124936007523 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1124936007524 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1124936007525 dimer interface [polypeptide binding]; other site 1124936007526 active site 1124936007527 citrylCoA binding site [chemical binding]; other site 1124936007528 NADH binding [chemical binding]; other site 1124936007529 cationic pore residues; other site 1124936007530 oxalacetate/citrate binding site [chemical binding]; other site 1124936007531 coenzyme A binding site [chemical binding]; other site 1124936007532 catalytic triad [active] 1124936007533 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1124936007534 Iron-sulfur protein interface; other site 1124936007535 proximal quinone binding site [chemical binding]; other site 1124936007536 SdhD (CybS) interface [polypeptide binding]; other site 1124936007537 proximal heme binding site [chemical binding]; other site 1124936007538 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1124936007539 SdhC subunit interface [polypeptide binding]; other site 1124936007540 proximal heme binding site [chemical binding]; other site 1124936007541 cardiolipin binding site; other site 1124936007542 Iron-sulfur protein interface; other site 1124936007543 proximal quinone binding site [chemical binding]; other site 1124936007544 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1124936007545 L-aspartate oxidase; Provisional; Region: PRK06175 1124936007546 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1124936007547 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1124936007548 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1124936007549 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1124936007550 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1124936007551 TPP-binding site [chemical binding]; other site 1124936007552 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1124936007553 dimer interface [polypeptide binding]; other site 1124936007554 PYR/PP interface [polypeptide binding]; other site 1124936007555 TPP binding site [chemical binding]; other site 1124936007556 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1124936007557 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124936007558 E3 interaction surface; other site 1124936007559 lipoyl attachment site [posttranslational modification]; other site 1124936007560 e3 binding domain; Region: E3_binding; pfam02817 1124936007561 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1124936007562 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1124936007563 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1124936007564 CoA-ligase; Region: Ligase_CoA; pfam00549 1124936007565 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1124936007566 CoA binding domain; Region: CoA_binding; smart00881 1124936007567 CoA-ligase; Region: Ligase_CoA; pfam00549 1124936007568 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1124936007569 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1124936007570 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1124936007571 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1124936007572 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 1124936007573 hypothetical protein; Provisional; Region: PRK10588 1124936007574 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124936007575 active site 1124936007576 colicin uptake protein TolQ; Provisional; Region: PRK10801 1124936007577 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124936007578 colicin uptake protein TolR; Provisional; Region: PRK11024 1124936007579 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1124936007580 TolA C-terminal; Region: TolA; pfam06519 1124936007581 translocation protein TolB; Provisional; Region: tolB; PRK03629 1124936007582 TolB amino-terminal domain; Region: TolB_N; pfam04052 1124936007583 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1124936007584 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1124936007585 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1124936007586 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1124936007587 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124936007588 ligand binding site [chemical binding]; other site 1124936007589 tol-pal system protein YbgF; Provisional; Region: PRK10803 1124936007590 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1124936007591 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1124936007592 quinolinate synthetase; Provisional; Region: PRK09375 1124936007593 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1124936007594 zinc transporter ZitB; Provisional; Region: PRK03557 1124936007595 YbgS-like protein; Region: YbgS; pfam13985 1124936007596 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1124936007597 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124936007598 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 1124936007599 fumarate hydratase; Provisional; Region: PRK06246 1124936007600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936007601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936007602 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936007603 dimerization interface [polypeptide binding]; other site 1124936007604 cell density-dependent motility repressor; Provisional; Region: PRK10082 1124936007605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936007606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936007607 dimerization interface [polypeptide binding]; other site 1124936007608 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1124936007609 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1124936007610 transmembrane helices; other site 1124936007611 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1124936007612 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1124936007613 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1124936007614 active site 1124936007615 catalytic residues [active] 1124936007616 metal binding site [ion binding]; metal-binding site 1124936007617 homodimer binding site [polypeptide binding]; other site 1124936007618 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124936007619 carboxyltransferase (CT) interaction site; other site 1124936007620 biotinylation site [posttranslational modification]; other site 1124936007621 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1124936007622 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1124936007623 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124936007624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936007625 dimer interface [polypeptide binding]; other site 1124936007626 putative PBP binding regions; other site 1124936007627 ABC-ATPase subunit interface; other site 1124936007628 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1124936007629 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124936007630 Walker A/P-loop; other site 1124936007631 ATP binding site [chemical binding]; other site 1124936007632 Q-loop/lid; other site 1124936007633 ABC transporter signature motif; other site 1124936007634 Walker B; other site 1124936007635 D-loop; other site 1124936007636 H-loop/switch region; other site 1124936007637 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124936007638 catalytic core [active] 1124936007639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124936007640 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1124936007641 active site 1124936007642 catalytic residues [active] 1124936007643 galactokinase; Provisional; Region: PRK05101 1124936007644 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1124936007645 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1124936007646 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1124936007647 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1124936007648 dimer interface [polypeptide binding]; other site 1124936007649 active site 1124936007650 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1124936007651 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1124936007652 NAD binding site [chemical binding]; other site 1124936007653 homodimer interface [polypeptide binding]; other site 1124936007654 active site 1124936007655 substrate binding site [chemical binding]; other site 1124936007656 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 1124936007657 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1124936007658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936007659 Walker A/P-loop; other site 1124936007660 ATP binding site [chemical binding]; other site 1124936007661 Q-loop/lid; other site 1124936007662 ABC transporter signature motif; other site 1124936007663 Walker B; other site 1124936007664 D-loop; other site 1124936007665 H-loop/switch region; other site 1124936007666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936007667 Walker A/P-loop; other site 1124936007668 ATP binding site [chemical binding]; other site 1124936007669 Q-loop/lid; other site 1124936007670 ABC transporter signature motif; other site 1124936007671 Walker B; other site 1124936007672 D-loop; other site 1124936007673 H-loop/switch region; other site 1124936007674 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1124936007675 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1124936007676 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1124936007677 TOBE domain; Region: TOBE; pfam03459 1124936007678 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1124936007679 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1124936007680 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936007681 substrate binding pocket [chemical binding]; other site 1124936007682 membrane-bound complex binding site; other site 1124936007683 hinge residues; other site 1124936007684 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1124936007685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936007686 dimer interface [polypeptide binding]; other site 1124936007687 conserved gate region; other site 1124936007688 putative PBP binding loops; other site 1124936007689 ABC-ATPase subunit interface; other site 1124936007690 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1124936007691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936007692 Walker A/P-loop; other site 1124936007693 ATP binding site [chemical binding]; other site 1124936007694 Q-loop/lid; other site 1124936007695 ABC transporter signature motif; other site 1124936007696 Walker B; other site 1124936007697 D-loop; other site 1124936007698 H-loop/switch region; other site 1124936007699 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1124936007700 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1124936007701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007702 active site 1124936007703 motif I; other site 1124936007704 motif II; other site 1124936007705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007706 6-phosphogluconolactonase; Provisional; Region: PRK11028 1124936007707 acyl-CoA thioesterase; Provisional; Region: PRK10531 1124936007708 putative pectinesterase; Region: PLN02432; cl01911 1124936007709 potential frameshift: common BLAST hit: gi|386590696|ref|YP_006087096.1| Imidazolonepropionase 1124936007710 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1124936007711 putative active site [active] 1124936007712 putative metal binding site [ion binding]; other site 1124936007713 histidine utilization repressor; Provisional; Region: PRK14999 1124936007714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936007715 DNA-binding site [nucleotide binding]; DNA binding site 1124936007716 UTRA domain; Region: UTRA; pfam07702 1124936007717 urocanate hydratase; Provisional; Region: PRK05414 1124936007718 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1124936007719 active sites [active] 1124936007720 tetramer interface [polypeptide binding]; other site 1124936007721 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1124936007722 substrate binding site [chemical binding]; other site 1124936007723 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1124936007724 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124936007725 inhibitor-cofactor binding pocket; inhibition site 1124936007726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936007727 catalytic residue [active] 1124936007728 biotin synthase; Provisional; Region: PRK15108 1124936007729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936007730 FeS/SAM binding site; other site 1124936007731 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1124936007732 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1124936007733 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1124936007734 substrate-cofactor binding pocket; other site 1124936007735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936007736 catalytic residue [active] 1124936007737 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1124936007738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936007739 S-adenosylmethionine binding site [chemical binding]; other site 1124936007740 AAA domain; Region: AAA_26; pfam13500 1124936007741 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1124936007742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936007743 ATP binding site [chemical binding]; other site 1124936007744 excinuclease ABC subunit B; Provisional; Region: PRK05298 1124936007745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936007746 nucleotide binding region [chemical binding]; other site 1124936007747 ATP-binding site [chemical binding]; other site 1124936007748 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1124936007749 UvrB/uvrC motif; Region: UVR; pfam02151 1124936007750 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1124936007751 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1124936007752 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1124936007753 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1124936007754 Leucine-rich repeats; other site 1124936007755 Substrate binding site [chemical binding]; other site 1124936007756 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1124936007757 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1124936007758 putative substrate binding pocket [chemical binding]; other site 1124936007759 dimer interface [polypeptide binding]; other site 1124936007760 phosphate binding site [ion binding]; other site 1124936007761 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1124936007762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936007763 FeS/SAM binding site; other site 1124936007764 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1124936007765 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1124936007766 MPT binding site; other site 1124936007767 trimer interface [polypeptide binding]; other site 1124936007768 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1124936007769 trimer interface [polypeptide binding]; other site 1124936007770 dimer interface [polypeptide binding]; other site 1124936007771 putative active site [active] 1124936007772 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1124936007773 MoaE interaction surface [polypeptide binding]; other site 1124936007774 MoeB interaction surface [polypeptide binding]; other site 1124936007775 thiocarboxylated glycine; other site 1124936007776 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1124936007777 MoaE homodimer interface [polypeptide binding]; other site 1124936007778 MoaD interaction [polypeptide binding]; other site 1124936007779 active site residues [active] 1124936007780 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1124936007781 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1124936007782 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1124936007783 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1124936007784 Predicted integral membrane protein [Function unknown]; Region: COG0392 1124936007785 cardiolipin synthase 2; Provisional; Region: PRK11263 1124936007786 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1124936007787 putative active site [active] 1124936007788 catalytic site [active] 1124936007789 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1124936007790 putative active site [active] 1124936007791 catalytic site [active] 1124936007792 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1124936007793 putative catalytic site [active] 1124936007794 putative metal binding site [ion binding]; other site 1124936007795 putative phosphate binding site [ion binding]; other site 1124936007796 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1124936007797 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124936007798 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124936007799 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124936007800 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1124936007801 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1124936007802 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124936007803 Walker A/P-loop; other site 1124936007804 ATP binding site [chemical binding]; other site 1124936007805 Q-loop/lid; other site 1124936007806 ABC transporter signature motif; other site 1124936007807 Walker B; other site 1124936007808 D-loop; other site 1124936007809 H-loop/switch region; other site 1124936007810 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1124936007811 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124936007812 Walker A/P-loop; other site 1124936007813 ATP binding site [chemical binding]; other site 1124936007814 Q-loop/lid; other site 1124936007815 ABC transporter signature motif; other site 1124936007816 Walker B; other site 1124936007817 D-loop; other site 1124936007818 H-loop/switch region; other site 1124936007819 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1124936007820 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936007821 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936007822 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1124936007823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936007824 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1124936007825 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1124936007826 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124936007827 ATP binding site [chemical binding]; other site 1124936007828 Mg++ binding site [ion binding]; other site 1124936007829 motif III; other site 1124936007830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936007831 nucleotide binding region [chemical binding]; other site 1124936007832 ATP-binding site [chemical binding]; other site 1124936007833 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1124936007834 DEAD_2; Region: DEAD_2; pfam06733 1124936007835 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1124936007836 glycosyl transferase family protein; Provisional; Region: PRK08136 1124936007837 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1124936007838 hypothetical protein; Provisional; Region: PRK10259 1124936007839 hypothetical protein; Provisional; Region: PRK11019 1124936007840 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1124936007841 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1124936007842 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1124936007843 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936007844 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1124936007845 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124936007846 Walker A/P-loop; other site 1124936007847 ATP binding site [chemical binding]; other site 1124936007848 Q-loop/lid; other site 1124936007849 ABC transporter signature motif; other site 1124936007850 Walker B; other site 1124936007851 D-loop; other site 1124936007852 H-loop/switch region; other site 1124936007853 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936007854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936007855 dimer interface [polypeptide binding]; other site 1124936007856 conserved gate region; other site 1124936007857 putative PBP binding loops; other site 1124936007858 ABC-ATPase subunit interface; other site 1124936007859 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1124936007860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936007861 substrate binding pocket [chemical binding]; other site 1124936007862 membrane-bound complex binding site; other site 1124936007863 hinge residues; other site 1124936007864 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1124936007865 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1124936007866 dimerization interface [polypeptide binding]; other site 1124936007867 DPS ferroxidase diiron center [ion binding]; other site 1124936007868 ion pore; other site 1124936007869 threonine and homoserine efflux system; Provisional; Region: PRK10532 1124936007870 EamA-like transporter family; Region: EamA; pfam00892 1124936007871 outer membrane protein X; Provisional; Region: ompX; PRK09408 1124936007872 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1124936007873 Sulfatase; Region: Sulfatase; pfam00884 1124936007874 manganese transport regulator MntR; Provisional; Region: PRK11050 1124936007875 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1124936007876 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1124936007877 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1124936007878 transmembrane helices; other site 1124936007879 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1124936007880 L,D-transpeptidase; Provisional; Region: PRK10260 1124936007881 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936007882 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1124936007883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936007884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936007885 Walker A/P-loop; other site 1124936007886 ATP binding site [chemical binding]; other site 1124936007887 ABC transporter signature motif; other site 1124936007888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936007889 Walker B; other site 1124936007890 ABC transporter; Region: ABC_tran_2; pfam12848 1124936007891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936007892 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1124936007893 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1124936007894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007895 active site 1124936007896 motif I; other site 1124936007897 motif II; other site 1124936007898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007899 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1124936007900 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1124936007901 dimer interface [polypeptide binding]; other site 1124936007902 active site 1124936007903 glycine loop; other site 1124936007904 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1124936007905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936007906 FeS/SAM binding site; other site 1124936007907 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1124936007908 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1124936007909 ATP binding site [chemical binding]; other site 1124936007910 substrate interface [chemical binding]; other site 1124936007911 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1124936007912 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1124936007913 dimer interface [polypeptide binding]; other site 1124936007914 putative functional site; other site 1124936007915 putative MPT binding site; other site 1124936007916 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1124936007917 catalytic nucleophile [active] 1124936007918 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1124936007919 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936007920 Walker A/P-loop; other site 1124936007921 ATP binding site [chemical binding]; other site 1124936007922 Q-loop/lid; other site 1124936007923 ABC transporter signature motif; other site 1124936007924 Walker B; other site 1124936007925 D-loop; other site 1124936007926 H-loop/switch region; other site 1124936007927 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124936007928 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936007929 Walker A/P-loop; other site 1124936007930 ATP binding site [chemical binding]; other site 1124936007931 Q-loop/lid; other site 1124936007932 ABC transporter signature motif; other site 1124936007933 Walker B; other site 1124936007934 D-loop; other site 1124936007935 H-loop/switch region; other site 1124936007936 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1124936007937 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1124936007938 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1124936007939 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1124936007940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936007941 dimer interface [polypeptide binding]; other site 1124936007942 conserved gate region; other site 1124936007943 putative PBP binding loops; other site 1124936007944 ABC-ATPase subunit interface; other site 1124936007945 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1124936007946 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1124936007947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936007948 dimer interface [polypeptide binding]; other site 1124936007949 conserved gate region; other site 1124936007950 putative PBP binding loops; other site 1124936007951 ABC-ATPase subunit interface; other site 1124936007952 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1124936007953 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1124936007954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936007955 FeS/SAM binding site; other site 1124936007956 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1124936007957 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1124936007958 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1124936007959 Ligand binding site [chemical binding]; other site 1124936007960 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1124936007961 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1124936007962 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1124936007963 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1124936007964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124936007965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124936007966 active site 1124936007967 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1124936007968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936007969 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1124936007970 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1124936007971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936007972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936007973 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1124936007974 putative dimerization interface [polypeptide binding]; other site 1124936007975 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1124936007976 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124936007977 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1124936007978 putative C-terminal domain interface [polypeptide binding]; other site 1124936007979 putative GSH binding site (G-site) [chemical binding]; other site 1124936007980 putative dimer interface [polypeptide binding]; other site 1124936007981 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1124936007982 putative N-terminal domain interface [polypeptide binding]; other site 1124936007983 putative dimer interface [polypeptide binding]; other site 1124936007984 putative substrate binding pocket (H-site) [chemical binding]; other site 1124936007985 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1124936007986 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1124936007987 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1124936007988 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1124936007989 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124936007990 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936007991 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124936007992 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1124936007993 active site 1124936007994 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1124936007995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936007996 putative substrate translocation pore; other site 1124936007997 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1124936007998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936007999 active site 1124936008000 motif I; other site 1124936008001 motif II; other site 1124936008002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936008003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936008004 putative substrate translocation pore; other site 1124936008005 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936008006 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1124936008007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936008008 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1124936008009 putative transporter; Provisional; Region: PRK04972 1124936008010 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1124936008011 TrkA-C domain; Region: TrkA_C; pfam02080 1124936008012 TrkA-C domain; Region: TrkA_C; pfam02080 1124936008013 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1124936008014 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1124936008015 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1124936008016 GSH binding site [chemical binding]; other site 1124936008017 catalytic residues [active] 1124936008018 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1124936008019 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1124936008020 dimer interface [polypeptide binding]; other site 1124936008021 FMN binding site [chemical binding]; other site 1124936008022 NADPH bind site [chemical binding]; other site 1124936008023 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1124936008024 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1124936008025 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1124936008026 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124936008027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124936008028 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1124936008029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008030 Walker A/P-loop; other site 1124936008031 ATP binding site [chemical binding]; other site 1124936008032 Q-loop/lid; other site 1124936008033 ABC transporter signature motif; other site 1124936008034 Walker B; other site 1124936008035 D-loop; other site 1124936008036 H-loop/switch region; other site 1124936008037 TOBE domain; Region: TOBE_2; pfam08402 1124936008038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936008039 dimer interface [polypeptide binding]; other site 1124936008040 conserved gate region; other site 1124936008041 putative PBP binding loops; other site 1124936008042 ABC-ATPase subunit interface; other site 1124936008043 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124936008044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936008045 dimer interface [polypeptide binding]; other site 1124936008046 conserved gate region; other site 1124936008047 putative PBP binding loops; other site 1124936008048 ABC-ATPase subunit interface; other site 1124936008049 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1124936008050 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1124936008051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936008052 S-adenosylmethionine binding site [chemical binding]; other site 1124936008053 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1124936008054 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1124936008055 active site 1124936008056 P-loop; other site 1124936008057 phosphorylation site [posttranslational modification] 1124936008058 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1124936008059 Sulfatase; Region: Sulfatase; cl17466 1124936008060 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1124936008061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936008062 substrate binding pocket [chemical binding]; other site 1124936008063 membrane-bound complex binding site; other site 1124936008064 hinge residues; other site 1124936008065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936008066 dimer interface [polypeptide binding]; other site 1124936008067 conserved gate region; other site 1124936008068 putative PBP binding loops; other site 1124936008069 ABC-ATPase subunit interface; other site 1124936008070 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936008071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936008072 dimer interface [polypeptide binding]; other site 1124936008073 conserved gate region; other site 1124936008074 putative PBP binding loops; other site 1124936008075 ABC-ATPase subunit interface; other site 1124936008076 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1124936008077 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936008078 substrate binding pocket [chemical binding]; other site 1124936008079 membrane-bound complex binding site; other site 1124936008080 hinge residues; other site 1124936008081 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1124936008082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008083 Walker A/P-loop; other site 1124936008084 ATP binding site [chemical binding]; other site 1124936008085 Q-loop/lid; other site 1124936008086 ABC transporter signature motif; other site 1124936008087 Walker B; other site 1124936008088 D-loop; other site 1124936008089 H-loop/switch region; other site 1124936008090 putative lipoprotein; Provisional; Region: PRK10533 1124936008091 hypothetical protein; Provisional; Region: PRK02877 1124936008092 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1124936008093 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1124936008094 amidase catalytic site [active] 1124936008095 Zn binding residues [ion binding]; other site 1124936008096 substrate binding site [chemical binding]; other site 1124936008097 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124936008098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124936008099 NAD(P) binding site [chemical binding]; other site 1124936008100 active site 1124936008101 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1124936008102 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1124936008103 putative NAD(P) binding site [chemical binding]; other site 1124936008104 putative active site [active] 1124936008105 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1124936008106 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1124936008107 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1124936008108 tetramer interface [polypeptide binding]; other site 1124936008109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936008110 catalytic residue [active] 1124936008111 pyruvate dehydrogenase; Provisional; Region: PRK09124 1124936008112 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1124936008113 PYR/PP interface [polypeptide binding]; other site 1124936008114 dimer interface [polypeptide binding]; other site 1124936008115 tetramer interface [polypeptide binding]; other site 1124936008116 TPP binding site [chemical binding]; other site 1124936008117 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124936008118 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1124936008119 TPP-binding site [chemical binding]; other site 1124936008120 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1124936008121 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1124936008122 FAD binding pocket [chemical binding]; other site 1124936008123 FAD binding motif [chemical binding]; other site 1124936008124 phosphate binding motif [ion binding]; other site 1124936008125 beta-alpha-beta structure motif; other site 1124936008126 NAD binding pocket [chemical binding]; other site 1124936008127 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124936008128 catalytic loop [active] 1124936008129 iron binding site [ion binding]; other site 1124936008130 hybrid cluster protein; Provisional; Region: PRK05290 1124936008131 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936008132 ACS interaction site; other site 1124936008133 CODH interaction site; other site 1124936008134 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1124936008135 hybrid metal cluster; other site 1124936008136 Predicted membrane protein [Function unknown]; Region: COG2431 1124936008137 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1124936008138 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1124936008139 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1124936008140 putative active site [active] 1124936008141 putative metal-binding site [ion binding]; other site 1124936008142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1124936008143 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1124936008144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936008145 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936008146 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1124936008147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124936008148 Walker A/P-loop; other site 1124936008149 ATP binding site [chemical binding]; other site 1124936008150 Q-loop/lid; other site 1124936008151 ABC transporter signature motif; other site 1124936008152 Walker B; other site 1124936008153 D-loop; other site 1124936008154 H-loop/switch region; other site 1124936008155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124936008156 FtsX-like permease family; Region: FtsX; pfam02687 1124936008157 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124936008158 DNA-binding site [nucleotide binding]; DNA binding site 1124936008159 RNA-binding motif; other site 1124936008160 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1124936008161 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1124936008162 Clp amino terminal domain; Region: Clp_N; pfam02861 1124936008163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936008164 Walker A motif; other site 1124936008165 ATP binding site [chemical binding]; other site 1124936008166 Walker B motif; other site 1124936008167 arginine finger; other site 1124936008168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936008169 Walker A motif; other site 1124936008170 ATP binding site [chemical binding]; other site 1124936008171 Walker B motif; other site 1124936008172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1124936008173 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1124936008174 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936008175 DNA binding site [nucleotide binding] 1124936008176 active site 1124936008177 Int/Topo IB signature motif; other site 1124936008178 Isochorismatase family; Region: Isochorismatase; pfam00857 1124936008179 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1124936008180 catalytic triad [active] 1124936008181 dimer interface [polypeptide binding]; other site 1124936008182 conserved cis-peptide bond; other site 1124936008183 Pirin-related protein [General function prediction only]; Region: COG1741 1124936008184 Pirin; Region: Pirin; pfam02678 1124936008185 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1124936008186 LysR family transcriptional regulator; Provisional; Region: PRK14997 1124936008187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936008188 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1124936008189 putative effector binding pocket; other site 1124936008190 putative dimerization interface [polypeptide binding]; other site 1124936008191 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1124936008192 rRNA binding site [nucleotide binding]; other site 1124936008193 predicted 30S ribosome binding site; other site 1124936008194 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1124936008195 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1124936008196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936008197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008198 Walker A/P-loop; other site 1124936008199 ATP binding site [chemical binding]; other site 1124936008200 Q-loop/lid; other site 1124936008201 ABC transporter signature motif; other site 1124936008202 Walker B; other site 1124936008203 D-loop; other site 1124936008204 H-loop/switch region; other site 1124936008205 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1124936008206 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936008207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008208 Walker A/P-loop; other site 1124936008209 ATP binding site [chemical binding]; other site 1124936008210 Q-loop/lid; other site 1124936008211 ABC transporter signature motif; other site 1124936008212 Walker B; other site 1124936008213 D-loop; other site 1124936008214 H-loop/switch region; other site 1124936008215 thioredoxin reductase; Provisional; Region: PRK10262 1124936008216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936008217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936008218 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1124936008219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936008220 putative DNA binding site [nucleotide binding]; other site 1124936008221 putative Zn2+ binding site [ion binding]; other site 1124936008222 AsnC family; Region: AsnC_trans_reg; pfam01037 1124936008223 DNA translocase FtsK; Provisional; Region: PRK10263 1124936008224 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1124936008225 DNA translocase FtsK; Provisional; Region: PRK10263 1124936008226 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1124936008227 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1124936008228 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1124936008229 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1124936008230 recombination factor protein RarA; Reviewed; Region: PRK13342 1124936008231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936008232 Walker A motif; other site 1124936008233 ATP binding site [chemical binding]; other site 1124936008234 Walker B motif; other site 1124936008235 arginine finger; other site 1124936008236 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1124936008237 seryl-tRNA synthetase; Provisional; Region: PRK05431 1124936008238 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1124936008239 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1124936008240 dimer interface [polypeptide binding]; other site 1124936008241 active site 1124936008242 motif 1; other site 1124936008243 motif 2; other site 1124936008244 motif 3; other site 1124936008245 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1124936008246 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1124936008247 putative [Fe4-S4] binding site [ion binding]; other site 1124936008248 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936008249 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1124936008250 putative molybdopterin cofactor binding site; other site 1124936008251 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1124936008252 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936008253 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1124936008254 putative MFS family transporter protein; Provisional; Region: PRK03633 1124936008255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936008256 putative substrate translocation pore; other site 1124936008257 inner membrane transporter YjeM; Provisional; Region: PRK15238 1124936008258 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1124936008259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936008260 FeS/SAM binding site; other site 1124936008261 integrase; Provisional; Region: int; PHA02601 1124936008262 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 1124936008263 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1124936008264 Pyruvate formate lyase 1; Region: PFL1; cd01678 1124936008265 coenzyme A binding site [chemical binding]; other site 1124936008266 active site 1124936008267 catalytic residues [active] 1124936008268 glycine loop; other site 1124936008269 formate transporter; Provisional; Region: PRK10805 1124936008270 uncharacterized domain; Region: TIGR00702 1124936008271 YcaO-like family; Region: YcaO; pfam02624 1124936008272 Predicted membrane protein [Function unknown]; Region: COG2323 1124936008273 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1124936008274 homodimer interface [polypeptide binding]; other site 1124936008275 substrate-cofactor binding pocket; other site 1124936008276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936008277 catalytic residue [active] 1124936008278 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1124936008279 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1124936008280 hinge; other site 1124936008281 active site 1124936008282 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1124936008283 cytidylate kinase; Provisional; Region: cmk; PRK00023 1124936008284 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1124936008285 CMP-binding site; other site 1124936008286 The sites determining sugar specificity; other site 1124936008287 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1124936008288 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1124936008289 RNA binding site [nucleotide binding]; other site 1124936008290 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1124936008291 RNA binding site [nucleotide binding]; other site 1124936008292 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1124936008293 RNA binding site [nucleotide binding]; other site 1124936008294 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1124936008295 RNA binding site [nucleotide binding]; other site 1124936008296 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1124936008297 RNA binding site [nucleotide binding]; other site 1124936008298 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124936008299 IHF dimer interface [polypeptide binding]; other site 1124936008300 IHF - DNA interface [nucleotide binding]; other site 1124936008301 ComEC family competence protein; Provisional; Region: PRK11539 1124936008302 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1124936008303 Competence protein; Region: Competence; pfam03772 1124936008304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1124936008305 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1124936008306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936008307 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1124936008308 Walker A/P-loop; other site 1124936008309 ATP binding site [chemical binding]; other site 1124936008310 Q-loop/lid; other site 1124936008311 ABC transporter signature motif; other site 1124936008312 Walker B; other site 1124936008313 D-loop; other site 1124936008314 H-loop/switch region; other site 1124936008315 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1124936008316 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1124936008317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1124936008318 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1124936008319 hypothetical protein; Provisional; Region: PRK11827 1124936008320 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1124936008321 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1124936008322 Ligand binding site; other site 1124936008323 oligomer interface; other site 1124936008324 hypothetical protein; Provisional; Region: PRK10593 1124936008325 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1124936008326 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1124936008327 putative active site [active] 1124936008328 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1124936008329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936008330 S-adenosylmethionine binding site [chemical binding]; other site 1124936008331 condesin subunit F; Provisional; Region: PRK05260 1124936008332 condesin subunit E; Provisional; Region: PRK05256 1124936008333 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1124936008334 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1124936008335 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1124936008336 murein L,D-transpeptidase; Provisional; Region: PRK10594 1124936008337 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1124936008338 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936008339 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936008340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1124936008341 Peptidase M15; Region: Peptidase_M15_3; cl01194 1124936008342 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1124936008343 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1124936008344 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936008345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936008346 homodimer interface [polypeptide binding]; other site 1124936008347 catalytic residue [active] 1124936008348 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936008349 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936008350 trimer interface [polypeptide binding]; other site 1124936008351 eyelet of channel; other site 1124936008352 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1124936008353 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1124936008354 putative dimer interface [polypeptide binding]; other site 1124936008355 putative anticodon binding site; other site 1124936008356 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1124936008357 homodimer interface [polypeptide binding]; other site 1124936008358 motif 1; other site 1124936008359 motif 2; other site 1124936008360 active site 1124936008361 motif 3; other site 1124936008362 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124936008363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936008364 putative DNA binding site [nucleotide binding]; other site 1124936008365 putative Zn2+ binding site [ion binding]; other site 1124936008366 AsnC family; Region: AsnC_trans_reg; pfam01037 1124936008367 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1124936008368 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1124936008369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936008370 catalytic residue [active] 1124936008371 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1124936008372 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1124936008373 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1124936008374 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1124936008375 active site 1124936008376 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1124936008377 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1124936008378 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1124936008379 Int/Topo IB signature motif; other site 1124936008380 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1124936008381 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1124936008382 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1124936008383 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1124936008384 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1124936008385 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1124936008386 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1124936008387 Tetrahydromethanopterin S-methyltransferase, subunit G; Region: MtrG; cl01679 1124936008388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936008389 transcriptional repressor DicA; Reviewed; Region: PRK09706 1124936008390 non-specific DNA binding site [nucleotide binding]; other site 1124936008391 salt bridge; other site 1124936008392 sequence-specific DNA binding site [nucleotide binding]; other site 1124936008393 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1124936008394 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1124936008395 Replication protein P; Region: Phage_lambda_P; pfam06992 1124936008396 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1124936008397 DinI-like family; Region: DinI; pfam06183 1124936008398 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1124936008399 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1124936008400 Antitermination protein; Region: Antiterm; pfam03589 1124936008401 Antitermination protein; Region: Antiterm; pfam03589 1124936008402 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1124936008403 catalytic residues [active] 1124936008404 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1124936008405 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1124936008406 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1124936008407 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 1124936008408 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1124936008409 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1124936008410 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1124936008411 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1124936008412 oligomer interface [polypeptide binding]; other site 1124936008413 active site residues [active] 1124936008414 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1124936008415 Uncharacterized conserved protein [Function unknown]; Region: COG5471 1124936008416 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1124936008417 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1124936008418 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1124936008419 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1124936008420 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1124936008421 Minor tail protein T; Region: Phage_tail_T; cl05636 1124936008422 Phage-related minor tail protein [Function unknown]; Region: COG5281 1124936008423 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1124936008424 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1124936008425 Phage-related protein [Function unknown]; Region: COG4718 1124936008426 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1124936008427 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1124936008428 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1124936008429 E-class dimer interface [polypeptide binding]; other site 1124936008430 P-class dimer interface [polypeptide binding]; other site 1124936008431 active site 1124936008432 Cu2+ binding site [ion binding]; other site 1124936008433 Zn2+ binding site [ion binding]; other site 1124936008434 Phage-related protein [Function unknown]; Region: gp18; COG4672 1124936008435 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1124936008436 MPN+ (JAMM) motif; other site 1124936008437 Zinc-binding site [ion binding]; other site 1124936008438 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1124936008439 NlpC/P60 family; Region: NLPC_P60; cl17555 1124936008440 Phage-related protein, tail component [Function unknown]; Region: COG4723 1124936008441 Phage-related protein, tail component [Function unknown]; Region: COG4733 1124936008442 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1124936008443 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1124936008444 Interdomain contacts; other site 1124936008445 Cytokine receptor motif; other site 1124936008446 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1124936008447 Fibronectin type III protein; Region: DUF3672; pfam12421 1124936008448 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1124936008449 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1124936008450 Phage Tail Collar Domain; Region: Collar; pfam07484 1124936008451 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1124936008452 ADP-ribose binding site [chemical binding]; other site 1124936008453 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1124936008454 type III secretion protein SopE; Provisional; Region: PRK15279 1124936008455 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1124936008456 SopE GEF domain; Region: SopE_GEF; pfam07487 1124936008457 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1124936008458 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1124936008459 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1124936008460 DNA-binding interface [nucleotide binding]; DNA binding site 1124936008461 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1124936008462 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1124936008463 aminopeptidase N; Provisional; Region: pepN; PRK14015 1124936008464 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1124936008465 active site 1124936008466 Zn binding site [ion binding]; other site 1124936008467 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1124936008468 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1124936008469 quinone interaction residues [chemical binding]; other site 1124936008470 active site 1124936008471 catalytic residues [active] 1124936008472 FMN binding site [chemical binding]; other site 1124936008473 substrate binding site [chemical binding]; other site 1124936008474 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1124936008475 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1124936008476 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1124936008477 MOSC domain; Region: MOSC; pfam03473 1124936008478 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1124936008479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124936008480 catalytic loop [active] 1124936008481 iron binding site [ion binding]; other site 1124936008482 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1124936008483 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1124936008484 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1124936008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936008486 S-adenosylmethionine binding site [chemical binding]; other site 1124936008487 ABC transporter ATPase component; Reviewed; Region: PRK11147 1124936008488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008490 Walker A/P-loop; other site 1124936008491 Walker A/P-loop; other site 1124936008492 ATP binding site [chemical binding]; other site 1124936008493 ATP binding site [chemical binding]; other site 1124936008494 Q-loop/lid; other site 1124936008495 Q-loop/lid; other site 1124936008496 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936008497 ABC transporter signature motif; other site 1124936008498 Walker B; other site 1124936008499 D-loop; other site 1124936008500 ABC transporter; Region: ABC_tran_2; pfam12848 1124936008501 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124936008502 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1124936008503 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124936008504 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124936008505 paraquat-inducible protein B; Provisional; Region: PRK10807 1124936008506 mce related protein; Region: MCE; pfam02470 1124936008507 mce related protein; Region: MCE; pfam02470 1124936008508 mce related protein; Region: MCE; pfam02470 1124936008509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1124936008510 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1124936008511 ribosome modulation factor; Provisional; Region: PRK14563 1124936008512 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1124936008513 active site 1 [active] 1124936008514 dimer interface [polypeptide binding]; other site 1124936008515 active site 2 [active] 1124936008516 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1124936008517 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1124936008518 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1124936008519 outer membrane protein A; Reviewed; Region: PRK10808 1124936008520 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1124936008521 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124936008522 ligand binding site [chemical binding]; other site 1124936008523 cell division inhibitor SulA; Region: sula; TIGR00623 1124936008524 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1124936008525 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1124936008526 TIGR01666 family membrane protein; Region: YCCS 1124936008527 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1124936008528 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124936008529 Predicted membrane protein [Function unknown]; Region: COG3304 1124936008530 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1124936008531 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1124936008532 DNA helicase IV; Provisional; Region: helD; PRK11054 1124936008533 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1124936008534 Part of AAA domain; Region: AAA_19; pfam13245 1124936008535 Family description; Region: UvrD_C_2; pfam13538 1124936008536 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1124936008537 active site 1124936008538 dimer interfaces [polypeptide binding]; other site 1124936008539 catalytic residues [active] 1124936008540 hypothetical protein; Provisional; Region: PRK03641 1124936008541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1124936008542 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1124936008543 heat shock protein HspQ; Provisional; Region: PRK14129 1124936008544 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1124936008545 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1124936008546 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1124936008547 putative RNA binding site [nucleotide binding]; other site 1124936008548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936008549 S-adenosylmethionine binding site [chemical binding]; other site 1124936008550 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1124936008551 substrate binding site [chemical binding]; other site 1124936008552 Cupin domain; Region: Cupin_2; cl17218 1124936008553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936008554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936008555 acylphosphatase; Provisional; Region: PRK14426 1124936008556 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1124936008557 sulfur transfer protein TusE; Provisional; Region: PRK11508 1124936008558 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1124936008559 YccA-like proteins; Region: YccA_like; cd10433 1124936008560 PipA protein; Region: PipA; pfam07108 1124936008561 secreted effector protein PipB; Provisional; Region: PRK15197 1124936008562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936008563 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936008564 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936008565 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 1124936008566 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 1124936008567 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 1124936008568 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1124936008569 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1124936008570 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1124936008571 HAMP domain; Region: HAMP; pfam00672 1124936008572 dimerization interface [polypeptide binding]; other site 1124936008573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936008574 dimer interface [polypeptide binding]; other site 1124936008575 phosphorylation site [posttranslational modification] 1124936008576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936008577 ATP binding site [chemical binding]; other site 1124936008578 Mg2+ binding site [ion binding]; other site 1124936008579 G-X-G motif; other site 1124936008580 Response regulator receiver domain; Region: Response_reg; pfam00072 1124936008581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936008582 active site 1124936008583 phosphorylation site [posttranslational modification] 1124936008584 intermolecular recognition site; other site 1124936008585 dimerization interface [polypeptide binding]; other site 1124936008586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1124936008587 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1124936008588 active site 1124936008589 homotetramer interface [polypeptide binding]; other site 1124936008590 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1124936008591 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1124936008592 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1124936008593 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1124936008594 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124936008595 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1124936008596 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1124936008597 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1124936008598 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1124936008599 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1124936008600 NAD binding site [chemical binding]; other site 1124936008601 catalytic residues [active] 1124936008602 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1124936008603 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1124936008604 putative active site [active] 1124936008605 putative metal binding site [ion binding]; other site 1124936008606 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1124936008607 putative substrate binding pocket [chemical binding]; other site 1124936008608 trimer interface [polypeptide binding]; other site 1124936008609 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1124936008610 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1124936008611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936008612 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1124936008613 putative substrate translocation pore; other site 1124936008614 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1124936008615 Cupin domain; Region: Cupin_2; pfam07883 1124936008616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936008617 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1124936008618 anti-adapter protein IraM; Provisional; Region: PRK09919 1124936008619 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1124936008620 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1124936008621 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1124936008622 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124936008623 HSP70 interaction site [polypeptide binding]; other site 1124936008624 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1124936008625 substrate binding site [polypeptide binding]; other site 1124936008626 dimer interface [polypeptide binding]; other site 1124936008627 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1124936008628 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1124936008629 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1124936008630 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1124936008631 DsbD alpha interface [polypeptide binding]; other site 1124936008632 catalytic residues [active] 1124936008633 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1124936008634 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1124936008635 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1124936008636 catalytic residues [active] 1124936008637 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1124936008638 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124936008639 catalytic residues [active] 1124936008640 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1124936008641 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1124936008642 catalytic core [active] 1124936008643 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1124936008644 hypothetical protein; Provisional; Region: PRK10174 1124936008645 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1124936008646 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124936008647 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1124936008648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936008649 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1124936008650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1124936008651 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1124936008652 Predicted transcriptional regulator [Transcription]; Region: COG3905 1124936008653 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1124936008654 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1124936008655 Glutamate binding site [chemical binding]; other site 1124936008656 NAD binding site [chemical binding]; other site 1124936008657 catalytic residues [active] 1124936008658 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1124936008659 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1124936008660 Na binding site [ion binding]; other site 1124936008661 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1124936008662 hypothetical protein; Provisional; Region: PRK10536 1124936008663 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1124936008664 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124936008665 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124936008666 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124936008667 putative active site [active] 1124936008668 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1124936008669 Na binding site [ion binding]; other site 1124936008670 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1124936008671 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1124936008672 putative active site cavity [active] 1124936008673 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1124936008674 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1124936008675 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1124936008676 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1124936008677 putative sialic acid transporter; Provisional; Region: PRK12307 1124936008678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936008679 putative substrate translocation pore; other site 1124936008680 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124936008681 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124936008682 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124936008683 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1124936008684 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1124936008685 putative ligand binding site [chemical binding]; other site 1124936008686 NAD binding site [chemical binding]; other site 1124936008687 dimerization interface [polypeptide binding]; other site 1124936008688 catalytic site [active] 1124936008689 putative hydrolase; Validated; Region: PRK09248 1124936008690 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1124936008691 active site 1124936008692 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1124936008693 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1124936008694 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1124936008695 curli assembly protein CsgF; Provisional; Region: PRK10050 1124936008696 curli assembly protein CsgE; Provisional; Region: PRK10386 1124936008697 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1124936008698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936008699 DNA binding residues [nucleotide binding] 1124936008700 dimerization interface [polypeptide binding]; other site 1124936008701 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1124936008702 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1124936008703 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1124936008704 major curlin subunit; Provisional; Region: csgA; PRK10051 1124936008705 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1124936008706 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1124936008707 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1124936008708 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1124936008709 putative ADP-ribose binding site [chemical binding]; other site 1124936008710 putative active site [active] 1124936008711 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1124936008712 PLD-like domain; Region: PLDc_2; pfam13091 1124936008713 putative active site [active] 1124936008714 catalytic site [active] 1124936008715 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1124936008716 PLD-like domain; Region: PLDc_2; pfam13091 1124936008717 putative active site [active] 1124936008718 catalytic site [active] 1124936008719 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1124936008720 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1124936008721 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1124936008722 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1124936008723 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124936008724 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1124936008725 Ligand binding site; other site 1124936008726 DXD motif; other site 1124936008727 lipoprotein; Provisional; Region: PRK10175 1124936008728 MsyB protein; Region: MsyB; cl08181 1124936008729 drug efflux system protein MdtG; Provisional; Region: PRK09874 1124936008730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936008731 putative substrate translocation pore; other site 1124936008732 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1124936008733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1124936008734 putative acyl-acceptor binding pocket; other site 1124936008735 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1124936008736 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1124936008737 active site residue [active] 1124936008738 hypothetical protein; Provisional; Region: PRK03757 1124936008739 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1124936008740 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1124936008741 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1124936008742 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124936008743 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1124936008744 DNA damage-inducible protein I; Provisional; Region: PRK10597 1124936008745 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1124936008746 active site 1124936008747 substrate binding pocket [chemical binding]; other site 1124936008748 dimer interface [polypeptide binding]; other site 1124936008749 lipoprotein; Provisional; Region: PRK10598 1124936008750 glutaredoxin 2; Provisional; Region: PRK10387 1124936008751 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1124936008752 C-terminal domain interface [polypeptide binding]; other site 1124936008753 GSH binding site (G-site) [chemical binding]; other site 1124936008754 catalytic residues [active] 1124936008755 putative dimer interface [polypeptide binding]; other site 1124936008756 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1124936008757 N-terminal domain interface [polypeptide binding]; other site 1124936008758 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1124936008759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936008760 putative substrate translocation pore; other site 1124936008761 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1124936008762 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1124936008763 hypothetical protein; Provisional; Region: PRK11239 1124936008764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1124936008765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124936008766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124936008767 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124936008768 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1124936008769 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1124936008770 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1124936008771 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1124936008772 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1124936008773 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1124936008774 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1124936008775 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1124936008776 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1124936008777 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1124936008778 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124936008779 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1124936008780 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1124936008781 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1124936008782 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1124936008783 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1124936008784 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124936008785 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1124936008786 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1124936008787 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1124936008788 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124936008789 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1124936008790 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1124936008791 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124936008792 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1124936008793 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1124936008794 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1124936008795 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1124936008796 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1124936008797 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1124936008798 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1124936008799 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1124936008800 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1124936008801 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1124936008802 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1124936008803 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1124936008804 ribonuclease E; Reviewed; Region: rne; PRK10811 1124936008805 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1124936008806 homodimer interface [polypeptide binding]; other site 1124936008807 oligonucleotide binding site [chemical binding]; other site 1124936008808 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1124936008809 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 1124936008810 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1124936008811 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936008812 RNA binding surface [nucleotide binding]; other site 1124936008813 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1124936008814 active site 1124936008815 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1124936008816 Maf-like protein; Region: Maf; pfam02545 1124936008817 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1124936008818 active site 1124936008819 dimer interface [polypeptide binding]; other site 1124936008820 hypothetical protein; Provisional; Region: PRK11193 1124936008821 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1124936008822 putative phosphate acyltransferase; Provisional; Region: PRK05331 1124936008823 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1124936008824 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1124936008825 dimer interface [polypeptide binding]; other site 1124936008826 active site 1124936008827 CoA binding pocket [chemical binding]; other site 1124936008828 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1124936008829 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1124936008830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1124936008831 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1124936008832 NAD(P) binding site [chemical binding]; other site 1124936008833 homotetramer interface [polypeptide binding]; other site 1124936008834 homodimer interface [polypeptide binding]; other site 1124936008835 active site 1124936008836 acyl carrier protein; Provisional; Region: acpP; PRK00982 1124936008837 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1124936008838 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124936008839 dimer interface [polypeptide binding]; other site 1124936008840 active site 1124936008841 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1124936008842 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1124936008843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936008844 catalytic residue [active] 1124936008845 conserved hypothetical protein, YceG family; Region: TIGR00247 1124936008846 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1124936008847 dimerization interface [polypeptide binding]; other site 1124936008848 thymidylate kinase; Validated; Region: tmk; PRK00698 1124936008849 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1124936008850 TMP-binding site; other site 1124936008851 ATP-binding site [chemical binding]; other site 1124936008852 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1124936008853 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1124936008854 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1124936008855 active site 1124936008856 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1124936008857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124936008858 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124936008859 active site turn [active] 1124936008860 phosphorylation site [posttranslational modification] 1124936008861 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1124936008862 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936008863 N-terminal plug; other site 1124936008864 ligand-binding site [chemical binding]; other site 1124936008865 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1124936008866 nucleotide binding site/active site [active] 1124936008867 HIT family signature motif; other site 1124936008868 catalytic residue [active] 1124936008869 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1124936008870 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1124936008871 putative dimer interface [polypeptide binding]; other site 1124936008872 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1124936008873 thiamine kinase; Region: ycfN_thiK; TIGR02721 1124936008874 thiamine kinase; Provisional; Region: thiK; PRK10271 1124936008875 substrate binding site [chemical binding]; other site 1124936008876 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1124936008877 beta-hexosaminidase; Provisional; Region: PRK05337 1124936008878 hypothetical protein; Provisional; Region: PRK04940 1124936008879 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1124936008880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936008881 hypothetical protein; Provisional; Region: PRK11280 1124936008882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124936008883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936008884 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936008885 L,D-transpeptidase; Provisional; Region: PRK10190 1124936008886 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936008887 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936008888 transcription-repair coupling factor; Provisional; Region: PRK10689 1124936008889 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1124936008890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936008891 ATP binding site [chemical binding]; other site 1124936008892 putative Mg++ binding site [ion binding]; other site 1124936008893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936008894 nucleotide binding region [chemical binding]; other site 1124936008895 ATP-binding site [chemical binding]; other site 1124936008896 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1124936008897 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1124936008898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124936008899 FtsX-like permease family; Region: FtsX; pfam02687 1124936008900 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1124936008901 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124936008902 Walker A/P-loop; other site 1124936008903 ATP binding site [chemical binding]; other site 1124936008904 Q-loop/lid; other site 1124936008905 ABC transporter signature motif; other site 1124936008906 Walker B; other site 1124936008907 D-loop; other site 1124936008908 H-loop/switch region; other site 1124936008909 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1124936008910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124936008911 FtsX-like permease family; Region: FtsX; pfam02687 1124936008912 fructokinase; Reviewed; Region: PRK09557 1124936008913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936008914 nucleotide binding site [chemical binding]; other site 1124936008915 NAD-dependent deacetylase; Provisional; Region: PRK00481 1124936008916 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1124936008917 NAD+ binding site [chemical binding]; other site 1124936008918 substrate binding site [chemical binding]; other site 1124936008919 Zn binding site [ion binding]; other site 1124936008920 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1124936008921 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1124936008922 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124936008923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936008924 dimer interface [polypeptide binding]; other site 1124936008925 conserved gate region; other site 1124936008926 putative PBP binding loops; other site 1124936008927 ABC-ATPase subunit interface; other site 1124936008928 Sif protein; Region: Sif; pfam06767 1124936008929 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1124936008930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936008931 dimer interface [polypeptide binding]; other site 1124936008932 conserved gate region; other site 1124936008933 putative PBP binding loops; other site 1124936008934 ABC-ATPase subunit interface; other site 1124936008935 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1124936008936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936008937 Walker A/P-loop; other site 1124936008938 ATP binding site [chemical binding]; other site 1124936008939 Q-loop/lid; other site 1124936008940 ABC transporter signature motif; other site 1124936008941 Walker B; other site 1124936008942 D-loop; other site 1124936008943 H-loop/switch region; other site 1124936008944 TOBE domain; Region: TOBE_2; pfam08402 1124936008945 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1124936008946 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1124936008947 metal binding site [ion binding]; metal-binding site 1124936008948 dimer interface [polypeptide binding]; other site 1124936008949 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1124936008950 Cupin-like domain; Region: Cupin_8; pfam13621 1124936008951 sensor protein PhoQ; Provisional; Region: PRK10815 1124936008952 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1124936008953 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1124936008954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936008955 ATP binding site [chemical binding]; other site 1124936008956 Mg2+ binding site [ion binding]; other site 1124936008957 G-X-G motif; other site 1124936008958 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1124936008959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936008960 active site 1124936008961 phosphorylation site [posttranslational modification] 1124936008962 intermolecular recognition site; other site 1124936008963 dimerization interface [polypeptide binding]; other site 1124936008964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936008965 DNA binding site [nucleotide binding] 1124936008966 adenylosuccinate lyase; Provisional; Region: PRK09285 1124936008967 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1124936008968 tetramer interface [polypeptide binding]; other site 1124936008969 active site 1124936008970 putative lysogenization regulator; Reviewed; Region: PRK00218 1124936008971 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1124936008972 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1124936008973 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1124936008974 nudix motif; other site 1124936008975 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1124936008976 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1124936008977 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1124936008978 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1124936008979 probable active site [active] 1124936008980 isocitrate dehydrogenase; Validated; Region: PRK07362 1124936008981 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1124936008982 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1124936008983 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1124936008984 DinI-like family; Region: DinI; pfam06183 1124936008985 Ricin-type beta-trefoil; Region: RICIN; smart00458 1124936008986 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1124936008987 putative sugar binding sites [chemical binding]; other site 1124936008988 Q-X-W motif; other site 1124936008989 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124936008990 DNA-binding site [nucleotide binding]; DNA binding site 1124936008991 RNA-binding motif; other site 1124936008992 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1124936008993 lysozyme inhibitor; Provisional; Region: PRK13791 1124936008994 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1124936008995 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1124936008996 putative dimer interface [polypeptide binding]; other site 1124936008997 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1124936008998 BNR repeat-like domain; Region: BNR_2; pfam13088 1124936008999 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1124936009000 TRL-like protein family; Region: TRL; pfam13146 1124936009001 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1124936009002 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1124936009003 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1124936009004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936009005 dimer interface [polypeptide binding]; other site 1124936009006 conserved gate region; other site 1124936009007 ABC-ATPase subunit interface; other site 1124936009008 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1124936009009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936009010 dimer interface [polypeptide binding]; other site 1124936009011 conserved gate region; other site 1124936009012 putative PBP binding loops; other site 1124936009013 ABC-ATPase subunit interface; other site 1124936009014 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936009015 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1124936009016 Walker A/P-loop; other site 1124936009017 ATP binding site [chemical binding]; other site 1124936009018 Q-loop/lid; other site 1124936009019 ABC transporter signature motif; other site 1124936009020 Walker B; other site 1124936009021 D-loop; other site 1124936009022 H-loop/switch region; other site 1124936009023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936009024 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1124936009025 Walker A/P-loop; other site 1124936009026 ATP binding site [chemical binding]; other site 1124936009027 Q-loop/lid; other site 1124936009028 ABC transporter signature motif; other site 1124936009029 Walker B; other site 1124936009030 D-loop; other site 1124936009031 H-loop/switch region; other site 1124936009032 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124936009033 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936009034 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1124936009035 dimerization interface [polypeptide binding]; other site 1124936009036 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1124936009037 aminoglycoside resistance protein; Provisional; Region: PRK13746 1124936009038 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1124936009039 active site 1124936009040 NTP binding site [chemical binding]; other site 1124936009041 metal binding triad [ion binding]; metal-binding site 1124936009042 antibiotic binding site [chemical binding]; other site 1124936009043 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1124936009044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936009045 DNA binding residues [nucleotide binding] 1124936009046 transcriptional regulator MirA; Provisional; Region: PRK15043 1124936009047 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1124936009048 DNA binding residues [nucleotide binding] 1124936009049 dimer interface [polypeptide binding]; other site 1124936009050 Pleckstrin homology-like domain; Region: PH-like; cl17171 1124936009051 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1124936009052 chorismate mutase; Provisional; Region: PRK08055 1124936009053 leucine export protein LeuE; Provisional; Region: PRK10958 1124936009054 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1124936009055 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1124936009056 hypothetical protein; Provisional; Region: PRK10457 1124936009057 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1124936009058 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1124936009059 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1124936009060 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1124936009061 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1124936009062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009063 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936009064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936009065 Predicted membrane protein [Function unknown]; Region: COG2707 1124936009066 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1124936009067 putative deacylase active site [active] 1124936009068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124936009069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936009070 metal binding site [ion binding]; metal-binding site 1124936009071 active site 1124936009072 I-site; other site 1124936009073 hypothetical protein; Provisional; Region: PRK05325 1124936009074 PrkA family serine protein kinase; Provisional; Region: PRK15455 1124936009075 AAA ATPase domain; Region: AAA_16; pfam13191 1124936009076 Walker A motif; other site 1124936009077 ATP binding site [chemical binding]; other site 1124936009078 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1124936009079 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1124936009080 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1124936009081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936009082 FeS/SAM binding site; other site 1124936009083 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124936009084 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936009085 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936009086 active site 1124936009087 catalytic tetrad [active] 1124936009088 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1124936009089 active site 1124936009090 phosphate binding residues; other site 1124936009091 catalytic residues [active] 1124936009092 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1124936009093 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1124936009094 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1124936009095 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1124936009096 SelR domain; Region: SelR; pfam01641 1124936009097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1124936009098 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1124936009099 Isochorismatase family; Region: Isochorismatase; pfam00857 1124936009100 catalytic triad [active] 1124936009101 metal binding site [ion binding]; metal-binding site 1124936009102 conserved cis-peptide bond; other site 1124936009103 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1124936009104 active site 1124936009105 homodimer interface [polypeptide binding]; other site 1124936009106 protease 4; Provisional; Region: PRK10949 1124936009107 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1124936009108 tandem repeat interface [polypeptide binding]; other site 1124936009109 oligomer interface [polypeptide binding]; other site 1124936009110 active site residues [active] 1124936009111 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1124936009112 tandem repeat interface [polypeptide binding]; other site 1124936009113 oligomer interface [polypeptide binding]; other site 1124936009114 active site residues [active] 1124936009115 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1124936009116 putative FMN binding site [chemical binding]; other site 1124936009117 selenophosphate synthetase; Provisional; Region: PRK00943 1124936009118 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1124936009119 dimerization interface [polypeptide binding]; other site 1124936009120 putative ATP binding site [chemical binding]; other site 1124936009121 DNA topoisomerase III; Provisional; Region: PRK07726 1124936009122 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1124936009123 active site 1124936009124 putative interdomain interaction site [polypeptide binding]; other site 1124936009125 putative metal-binding site [ion binding]; other site 1124936009126 putative nucleotide binding site [chemical binding]; other site 1124936009127 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1124936009128 domain I; other site 1124936009129 DNA binding groove [nucleotide binding] 1124936009130 phosphate binding site [ion binding]; other site 1124936009131 domain II; other site 1124936009132 domain III; other site 1124936009133 nucleotide binding site [chemical binding]; other site 1124936009134 catalytic site [active] 1124936009135 domain IV; other site 1124936009136 glutamate dehydrogenase; Provisional; Region: PRK09414 1124936009137 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1124936009138 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1124936009139 NAD(P) binding site [chemical binding]; other site 1124936009140 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1124936009141 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1124936009142 active site 1124936009143 8-oxo-dGMP binding site [chemical binding]; other site 1124936009144 nudix motif; other site 1124936009145 metal binding site [ion binding]; metal-binding site 1124936009146 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1124936009147 putative catalytic site [active] 1124936009148 putative phosphate binding site [ion binding]; other site 1124936009149 active site 1124936009150 metal binding site A [ion binding]; metal-binding site 1124936009151 DNA binding site [nucleotide binding] 1124936009152 putative AP binding site [nucleotide binding]; other site 1124936009153 putative metal binding site B [ion binding]; other site 1124936009154 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1124936009155 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124936009156 inhibitor-cofactor binding pocket; inhibition site 1124936009157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936009158 catalytic residue [active] 1124936009159 arginine succinyltransferase; Provisional; Region: PRK10456 1124936009160 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1124936009161 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1124936009162 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1124936009163 NAD(P) binding site [chemical binding]; other site 1124936009164 catalytic residues [active] 1124936009165 succinylarginine dihydrolase; Provisional; Region: PRK13281 1124936009166 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1124936009167 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1124936009168 putative active site [active] 1124936009169 Zn binding site [ion binding]; other site 1124936009170 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1124936009171 dimer interface [polypeptide binding]; other site 1124936009172 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1124936009173 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1124936009174 GIY-YIG motif/motif A; other site 1124936009175 active site 1124936009176 catalytic site [active] 1124936009177 putative DNA binding site [nucleotide binding]; other site 1124936009178 metal binding site [ion binding]; metal-binding site 1124936009179 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1124936009180 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1124936009181 homodimer interface [polypeptide binding]; other site 1124936009182 NAD binding pocket [chemical binding]; other site 1124936009183 ATP binding pocket [chemical binding]; other site 1124936009184 Mg binding site [ion binding]; other site 1124936009185 active-site loop [active] 1124936009186 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1124936009187 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1124936009188 active site 1124936009189 P-loop; other site 1124936009190 phosphorylation site [posttranslational modification] 1124936009191 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1124936009192 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1124936009193 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1124936009194 methionine cluster; other site 1124936009195 active site 1124936009196 phosphorylation site [posttranslational modification] 1124936009197 metal binding site [ion binding]; metal-binding site 1124936009198 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1124936009199 Cupin domain; Region: Cupin_2; pfam07883 1124936009200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936009201 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1124936009202 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1124936009203 NAD binding site [chemical binding]; other site 1124936009204 sugar binding site [chemical binding]; other site 1124936009205 divalent metal binding site [ion binding]; other site 1124936009206 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124936009207 dimer interface [polypeptide binding]; other site 1124936009208 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1124936009209 putative active site [active] 1124936009210 YdjC motif; other site 1124936009211 Mg binding site [ion binding]; other site 1124936009212 putative homodimer interface [polypeptide binding]; other site 1124936009213 hydroperoxidase II; Provisional; Region: katE; PRK11249 1124936009214 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1124936009215 tetramer interface [polypeptide binding]; other site 1124936009216 heme binding pocket [chemical binding]; other site 1124936009217 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1124936009218 domain interactions; other site 1124936009219 cell division modulator; Provisional; Region: PRK10113 1124936009220 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1124936009221 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124936009222 inner membrane protein; Provisional; Region: PRK11648 1124936009223 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1124936009224 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124936009225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936009226 motif II; other site 1124936009227 YniB-like protein; Region: YniB; pfam14002 1124936009228 Phosphotransferase enzyme family; Region: APH; pfam01636 1124936009229 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1124936009230 active site 1124936009231 ATP binding site [chemical binding]; other site 1124936009232 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1124936009233 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1124936009234 6-phosphofructokinase 2; Provisional; Region: PRK10294 1124936009235 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1124936009236 putative substrate binding site [chemical binding]; other site 1124936009237 putative ATP binding site [chemical binding]; other site 1124936009238 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1124936009239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1124936009240 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1124936009241 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1124936009242 active site 1124936009243 substrate binding site [chemical binding]; other site 1124936009244 Mg2+ binding site [ion binding]; other site 1124936009245 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1124936009246 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1124936009247 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1124936009248 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1124936009249 active site 1124936009250 dimer interface [polypeptide binding]; other site 1124936009251 motif 1; other site 1124936009252 motif 2; other site 1124936009253 motif 3; other site 1124936009254 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1124936009255 anticodon binding site; other site 1124936009256 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1124936009257 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1124936009258 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1124936009259 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1124936009260 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1124936009261 23S rRNA binding site [nucleotide binding]; other site 1124936009262 L21 binding site [polypeptide binding]; other site 1124936009263 L13 binding site [polypeptide binding]; other site 1124936009264 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1124936009265 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1124936009266 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1124936009267 dimer interface [polypeptide binding]; other site 1124936009268 motif 1; other site 1124936009269 active site 1124936009270 motif 2; other site 1124936009271 motif 3; other site 1124936009272 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1124936009273 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1124936009274 putative tRNA-binding site [nucleotide binding]; other site 1124936009275 B3/4 domain; Region: B3_4; pfam03483 1124936009276 tRNA synthetase B5 domain; Region: B5; smart00874 1124936009277 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1124936009278 dimer interface [polypeptide binding]; other site 1124936009279 motif 1; other site 1124936009280 motif 3; other site 1124936009281 motif 2; other site 1124936009282 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1124936009283 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124936009284 IHF dimer interface [polypeptide binding]; other site 1124936009285 IHF - DNA interface [nucleotide binding]; other site 1124936009286 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124936009287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936009288 ABC-ATPase subunit interface; other site 1124936009289 dimer interface [polypeptide binding]; other site 1124936009290 putative PBP binding regions; other site 1124936009291 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1124936009292 catalytic residues [active] 1124936009293 dimer interface [polypeptide binding]; other site 1124936009294 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 1124936009295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124936009296 Walker A/P-loop; other site 1124936009297 ATP binding site [chemical binding]; other site 1124936009298 Q-loop/lid; other site 1124936009299 ABC transporter signature motif; other site 1124936009300 Walker B; other site 1124936009301 D-loop; other site 1124936009302 H-loop/switch region; other site 1124936009303 NlpC/P60 family; Region: NLPC_P60; pfam00877 1124936009304 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1124936009305 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1124936009306 hypothetical protein; Validated; Region: PRK00029 1124936009307 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1124936009308 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1124936009309 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124936009310 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1124936009311 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1124936009312 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1124936009313 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124936009314 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124936009315 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1124936009316 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1124936009317 acyl-activating enzyme (AAE) consensus motif; other site 1124936009318 putative AMP binding site [chemical binding]; other site 1124936009319 putative active site [active] 1124936009320 putative CoA binding site [chemical binding]; other site 1124936009321 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1124936009322 oxidoreductase; Provisional; Region: PRK10015 1124936009323 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1124936009324 Electron transfer flavoprotein domain; Region: ETF; smart00893 1124936009325 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1124936009326 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1124936009327 Ligand binding site [chemical binding]; other site 1124936009328 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1124936009329 Cupin domain; Region: Cupin_2; pfam07883 1124936009330 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936009331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936009332 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1124936009333 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1124936009334 active site 1124936009335 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1124936009336 Coenzyme A transferase; Region: CoA_trans; smart00882 1124936009337 Coenzyme A transferase; Region: CoA_trans; cl17247 1124936009338 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1124936009339 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1124936009340 active site 1124936009341 catalytic residue [active] 1124936009342 dimer interface [polypeptide binding]; other site 1124936009343 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1124936009344 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1124936009345 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1124936009346 shikimate binding site; other site 1124936009347 NAD(P) binding site [chemical binding]; other site 1124936009348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936009350 putative substrate translocation pore; other site 1124936009351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936009353 putative substrate translocation pore; other site 1124936009354 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1124936009355 putative inner membrane protein; Provisional; Region: PRK10983 1124936009356 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124936009357 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124936009358 FAD binding domain; Region: FAD_binding_4; pfam01565 1124936009359 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1124936009360 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124936009361 CoenzymeA binding site [chemical binding]; other site 1124936009362 subunit interaction site [polypeptide binding]; other site 1124936009363 PHB binding site; other site 1124936009364 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1124936009365 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124936009366 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1124936009367 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1124936009368 putative ABC transporter; Region: ycf24; CHL00085 1124936009369 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1124936009370 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1124936009371 Walker A/P-loop; other site 1124936009372 ATP binding site [chemical binding]; other site 1124936009373 Q-loop/lid; other site 1124936009374 ABC transporter signature motif; other site 1124936009375 Walker B; other site 1124936009376 D-loop; other site 1124936009377 H-loop/switch region; other site 1124936009378 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1124936009379 FeS assembly protein SufD; Region: sufD; TIGR01981 1124936009380 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1124936009381 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1124936009382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936009383 catalytic residue [active] 1124936009384 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1124936009385 L,D-transpeptidase; Provisional; Region: PRK10190 1124936009386 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936009387 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936009388 murein lipoprotein; Provisional; Region: PRK15396 1124936009389 murein lipoprotein; Provisional; Region: PRK15396 1124936009390 murein lipoprotein; Provisional; Region: PRK15396 1124936009391 pyruvate kinase; Provisional; Region: PRK09206 1124936009392 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1124936009393 domain interfaces; other site 1124936009394 active site 1124936009395 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124936009396 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1124936009397 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1124936009398 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936009399 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936009400 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936009401 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1124936009402 substrate binding site [chemical binding]; other site 1124936009403 dimer interface [polypeptide binding]; other site 1124936009404 ATP binding site [chemical binding]; other site 1124936009405 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1124936009406 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1124936009407 putative [Fe4-S4] binding site [ion binding]; other site 1124936009408 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936009409 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1124936009410 putative molybdopterin cofactor binding site; other site 1124936009411 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1124936009412 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1124936009413 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1124936009414 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936009415 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1124936009416 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1124936009417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124936009418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936009419 dimer interface [polypeptide binding]; other site 1124936009420 phosphorylation site [posttranslational modification] 1124936009421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936009422 ATP binding site [chemical binding]; other site 1124936009423 Mg2+ binding site [ion binding]; other site 1124936009424 G-X-G motif; other site 1124936009425 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1124936009426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936009427 active site 1124936009428 phosphorylation site [posttranslational modification] 1124936009429 intermolecular recognition site; other site 1124936009430 dimerization interface [polypeptide binding]; other site 1124936009431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936009432 DNA binding residues [nucleotide binding] 1124936009433 dimerization interface [polypeptide binding]; other site 1124936009434 hypothetical protein; Provisional; Region: PRK10292 1124936009435 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1124936009436 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1124936009437 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1124936009438 transcriptional regulator MirA; Provisional; Region: PRK15043 1124936009439 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1124936009440 DNA binding residues [nucleotide binding] 1124936009441 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1124936009442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936009443 active site 1124936009444 phosphorylation site [posttranslational modification] 1124936009445 intermolecular recognition site; other site 1124936009446 dimerization interface [polypeptide binding]; other site 1124936009447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936009448 DNA binding residues [nucleotide binding] 1124936009449 dimerization interface [polypeptide binding]; other site 1124936009450 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1124936009451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936009452 dimerization interface [polypeptide binding]; other site 1124936009453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936009454 dimer interface [polypeptide binding]; other site 1124936009455 phosphorylation site [posttranslational modification] 1124936009456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936009457 ATP binding site [chemical binding]; other site 1124936009458 Mg2+ binding site [ion binding]; other site 1124936009459 G-X-G motif; other site 1124936009460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936009461 active site 1124936009462 phosphorylation site [posttranslational modification] 1124936009463 intermolecular recognition site; other site 1124936009464 dimerization interface [polypeptide binding]; other site 1124936009465 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 1124936009466 outer membrane secretin SsaC; Provisional; Region: PRK15346 1124936009467 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124936009468 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124936009469 type III secretion system protein SsaD; Provisional; Region: PRK15367 1124936009470 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1124936009471 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 1124936009472 type III secretion system chaperone SseA; Provisional; Region: PRK15365 1124936009473 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 1124936009474 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 1124936009475 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 1124936009476 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 1124936009477 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 1124936009478 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 1124936009479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124936009480 TPR motif; other site 1124936009481 binding surface 1124936009482 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 1124936009483 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 1124936009484 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 1124936009485 type III secretion system protein SsaH; Provisional; Region: PRK15356 1124936009486 type III secretion system protein SsaI; Provisional; Region: PRK15355 1124936009487 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 1124936009488 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 1124936009489 type III secretion system protein SsaK; Provisional; Region: PRK15354 1124936009490 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1124936009491 type III secretion system protein SsaL; Provisional; Region: PRK15345 1124936009492 HrpJ-like domain; Region: HrpJ; pfam07201 1124936009493 TyeA; Region: TyeA; cl07611 1124936009494 type III secretion system protein SsaM; Provisional; Region: PRK15353 1124936009495 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 1124936009496 FHIPEP family; Region: FHIPEP; pfam00771 1124936009497 type III secretion system ATPase SsaN; Validated; Region: PRK07594 1124936009498 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124936009499 Walker A motif; other site 1124936009500 ATP binding site [chemical binding]; other site 1124936009501 Walker B motif; other site 1124936009502 type III secretion system protein SsaO; Provisional; Region: PRK15352 1124936009503 type III secretion system protein SsaP; Provisional; Region: PRK15351 1124936009504 type III secretion system protein SsaQ; Validated; Region: PRK08035 1124936009505 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1124936009506 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1124936009507 type III secretion system protein SsaS; Provisional; Region: PRK15350 1124936009508 type III secretion system protein SsaT; Provisional; Region: PRK15349 1124936009509 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 1124936009510 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1124936009511 multidrug efflux protein; Reviewed; Region: PRK01766 1124936009512 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1124936009513 cation binding site [ion binding]; other site 1124936009514 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1124936009515 Lumazine binding domain; Region: Lum_binding; pfam00677 1124936009516 Lumazine binding domain; Region: Lum_binding; pfam00677 1124936009517 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1124936009518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936009519 S-adenosylmethionine binding site [chemical binding]; other site 1124936009520 putative transporter; Provisional; Region: PRK11043 1124936009521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009522 putative substrate translocation pore; other site 1124936009523 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1124936009524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936009525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936009526 dimerization interface [polypeptide binding]; other site 1124936009527 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1124936009528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936009529 DNA binding site [nucleotide binding] 1124936009530 domain linker motif; other site 1124936009531 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1124936009532 dimerization interface [polypeptide binding]; other site 1124936009533 ligand binding site [chemical binding]; other site 1124936009534 superoxide dismutase; Provisional; Region: PRK10543 1124936009535 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1124936009536 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1124936009537 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1124936009538 NlpC/P60 family; Region: NLPC_P60; pfam00877 1124936009539 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1124936009540 putative GSH binding site [chemical binding]; other site 1124936009541 catalytic residues [active] 1124936009542 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1124936009543 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1124936009544 dimer interface [polypeptide binding]; other site 1124936009545 catalytic site [active] 1124936009546 putative active site [active] 1124936009547 putative substrate binding site [chemical binding]; other site 1124936009548 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124936009549 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1124936009550 dimer interface [polypeptide binding]; other site 1124936009551 active site 1124936009552 metal binding site [ion binding]; metal-binding site 1124936009553 glutathione binding site [chemical binding]; other site 1124936009554 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124936009555 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1124936009556 FMN binding site [chemical binding]; other site 1124936009557 active site 1124936009558 substrate binding site [chemical binding]; other site 1124936009559 catalytic residue [active] 1124936009560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124936009561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936009562 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1124936009563 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936009564 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936009565 active site 1124936009566 catalytic tetrad [active] 1124936009567 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1124936009568 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1124936009569 E-class dimer interface [polypeptide binding]; other site 1124936009570 P-class dimer interface [polypeptide binding]; other site 1124936009571 active site 1124936009572 Cu2+ binding site [ion binding]; other site 1124936009573 Zn2+ binding site [ion binding]; other site 1124936009574 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1124936009575 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124936009576 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1124936009577 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936009578 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936009579 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1124936009580 transcriptional regulator SlyA; Provisional; Region: PRK03573 1124936009581 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1124936009582 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1124936009583 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1124936009584 lysozyme inhibitor; Provisional; Region: PRK11372 1124936009585 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1124936009586 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1124936009587 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1124936009588 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1124936009589 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1124936009590 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1124936009591 active site 1124936009592 HIGH motif; other site 1124936009593 dimer interface [polypeptide binding]; other site 1124936009594 KMSKS motif; other site 1124936009595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936009596 RNA binding surface [nucleotide binding]; other site 1124936009597 pyridoxamine kinase; Validated; Region: PRK05756 1124936009598 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1124936009599 dimer interface [polypeptide binding]; other site 1124936009600 pyridoxal binding site [chemical binding]; other site 1124936009601 ATP binding site [chemical binding]; other site 1124936009602 glutathionine S-transferase; Provisional; Region: PRK10542 1124936009603 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1124936009604 C-terminal domain interface [polypeptide binding]; other site 1124936009605 GSH binding site (G-site) [chemical binding]; other site 1124936009606 dimer interface [polypeptide binding]; other site 1124936009607 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1124936009608 dimer interface [polypeptide binding]; other site 1124936009609 N-terminal domain interface [polypeptide binding]; other site 1124936009610 substrate binding pocket (H-site) [chemical binding]; other site 1124936009611 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1124936009612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009613 putative substrate translocation pore; other site 1124936009614 POT family; Region: PTR2; pfam00854 1124936009615 endonuclease III; Provisional; Region: PRK10702 1124936009616 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124936009617 minor groove reading motif; other site 1124936009618 helix-hairpin-helix signature motif; other site 1124936009619 substrate binding pocket [chemical binding]; other site 1124936009620 active site 1124936009621 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1124936009622 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1124936009623 electron transport complex protein RnfG; Validated; Region: PRK01908 1124936009624 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1124936009625 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1124936009626 SLBB domain; Region: SLBB; pfam10531 1124936009627 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936009628 electron transport complex protein RnfB; Provisional; Region: PRK05113 1124936009629 Putative Fe-S cluster; Region: FeS; cl17515 1124936009630 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936009631 electron transport complex protein RsxA; Provisional; Region: PRK05151 1124936009632 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1124936009633 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1124936009634 putative oxidoreductase; Provisional; Region: PRK11579 1124936009635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124936009636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124936009637 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1124936009638 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1124936009639 active site 1124936009640 purine riboside binding site [chemical binding]; other site 1124936009641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1124936009642 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1124936009643 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1124936009644 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1124936009645 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1124936009646 fumarate hydratase; Provisional; Region: PRK15389 1124936009647 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1124936009648 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1124936009649 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1124936009650 Class II fumarases; Region: Fumarase_classII; cd01362 1124936009651 active site 1124936009652 tetramer interface [polypeptide binding]; other site 1124936009653 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1124936009654 sensor protein RstB; Provisional; Region: PRK10604 1124936009655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936009656 dimerization interface [polypeptide binding]; other site 1124936009657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936009658 dimer interface [polypeptide binding]; other site 1124936009659 phosphorylation site [posttranslational modification] 1124936009660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936009661 ATP binding site [chemical binding]; other site 1124936009662 Mg2+ binding site [ion binding]; other site 1124936009663 G-X-G motif; other site 1124936009664 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124936009665 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1124936009666 active site 1124936009667 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936009668 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936009669 trimer interface [polypeptide binding]; other site 1124936009670 eyelet of channel; other site 1124936009671 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1124936009672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936009673 active site 1124936009674 phosphorylation site [posttranslational modification] 1124936009675 intermolecular recognition site; other site 1124936009676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936009677 DNA binding site [nucleotide binding] 1124936009678 GlpM protein; Region: GlpM; pfam06942 1124936009679 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1124936009680 Spore germination protein; Region: Spore_permease; cl17796 1124936009681 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936009682 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936009683 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1124936009684 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1124936009685 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1124936009686 ligand binding site [chemical binding]; other site 1124936009687 homodimer interface [polypeptide binding]; other site 1124936009688 NAD(P) binding site [chemical binding]; other site 1124936009689 trimer interface B [polypeptide binding]; other site 1124936009690 trimer interface A [polypeptide binding]; other site 1124936009691 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1124936009692 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1124936009693 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1124936009694 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1124936009695 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124936009696 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1124936009697 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1124936009698 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1124936009699 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124936009700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009701 putative substrate translocation pore; other site 1124936009702 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1124936009703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936009704 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124936009705 dimerization interface [polypeptide binding]; other site 1124936009706 substrate binding pocket [chemical binding]; other site 1124936009707 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1124936009708 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1124936009709 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936009710 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1124936009711 AAA domain; Region: AAA_26; pfam13500 1124936009712 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1124936009713 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1124936009714 Cl- selectivity filter; other site 1124936009715 Cl- binding residues [ion binding]; other site 1124936009716 pore gating glutamate residue; other site 1124936009717 dimer interface [polypeptide binding]; other site 1124936009718 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1124936009719 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1124936009720 Walker A/P-loop; other site 1124936009721 ATP binding site [chemical binding]; other site 1124936009722 Q-loop/lid; other site 1124936009723 ABC transporter signature motif; other site 1124936009724 Walker B; other site 1124936009725 D-loop; other site 1124936009726 H-loop/switch region; other site 1124936009727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1124936009728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936009729 dimer interface [polypeptide binding]; other site 1124936009730 conserved gate region; other site 1124936009731 ABC-ATPase subunit interface; other site 1124936009732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1124936009733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936009734 dimer interface [polypeptide binding]; other site 1124936009735 conserved gate region; other site 1124936009736 putative PBP binding loops; other site 1124936009737 ABC-ATPase subunit interface; other site 1124936009738 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1124936009739 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1124936009740 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1124936009741 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936009742 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1124936009743 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1124936009744 putative [Fe4-S4] binding site [ion binding]; other site 1124936009745 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936009746 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1124936009747 putative molybdopterin cofactor binding site; other site 1124936009748 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1124936009749 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1124936009750 putative [Fe4-S4] binding site [ion binding]; other site 1124936009751 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936009752 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1124936009753 putative molybdopterin cofactor binding site; other site 1124936009754 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1124936009755 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1124936009756 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1124936009757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936009758 Coenzyme A binding pocket [chemical binding]; other site 1124936009759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124936009760 hypothetical protein; Provisional; Region: PRK13659 1124936009761 hypothetical protein; Provisional; Region: PRK02237 1124936009762 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1124936009763 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1124936009764 putative active site pocket [active] 1124936009765 putative metal binding site [ion binding]; other site 1124936009766 putative oxidoreductase; Provisional; Region: PRK10083 1124936009767 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1124936009768 putative NAD(P) binding site [chemical binding]; other site 1124936009769 catalytic Zn binding site [ion binding]; other site 1124936009770 structural Zn binding site [ion binding]; other site 1124936009771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009772 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124936009773 putative substrate translocation pore; other site 1124936009774 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1124936009775 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1124936009776 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1124936009777 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1124936009778 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124936009779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936009780 DNA-binding site [nucleotide binding]; DNA binding site 1124936009781 FCD domain; Region: FCD; pfam07729 1124936009782 malonic semialdehyde reductase; Provisional; Region: PRK10538 1124936009783 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1124936009784 putative NAD(P) binding site [chemical binding]; other site 1124936009785 homodimer interface [polypeptide binding]; other site 1124936009786 homotetramer interface [polypeptide binding]; other site 1124936009787 active site 1124936009788 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1124936009789 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1124936009790 active site 1124936009791 Zn binding site [ion binding]; other site 1124936009792 hypothetical protein; Validated; Region: PRK03657 1124936009793 hypothetical protein; Provisional; Region: PRK10053 1124936009794 putative transporter; Provisional; Region: PRK10054 1124936009795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009796 putative substrate translocation pore; other site 1124936009797 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1124936009798 EamA-like transporter family; Region: EamA; pfam00892 1124936009799 MarB protein; Region: MarB; pfam13999 1124936009800 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1124936009801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936009802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936009803 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1124936009804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124936009805 inner membrane protein; Provisional; Region: PRK10995 1124936009806 putative arabinose transporter; Provisional; Region: PRK03545 1124936009807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009808 putative substrate translocation pore; other site 1124936009809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936009810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936009811 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1124936009812 putative dimerization interface [polypeptide binding]; other site 1124936009813 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1124936009814 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1124936009815 NAD(P) binding site [chemical binding]; other site 1124936009816 catalytic residues [active] 1124936009817 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1124936009818 glutaminase; Provisional; Region: PRK00971 1124936009819 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1124936009820 Predicted membrane protein [Function unknown]; Region: COG3781 1124936009821 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1124936009822 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936009823 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936009824 trimer interface [polypeptide binding]; other site 1124936009825 eyelet of channel; other site 1124936009826 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1124936009827 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1124936009828 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1124936009829 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1124936009830 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1124936009831 Rubredoxin [Energy production and conversion]; Region: COG1773 1124936009832 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1124936009833 iron binding site [ion binding]; other site 1124936009834 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1124936009835 HupF/HypC family; Region: HupF_HypC; cl00394 1124936009836 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1124936009837 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1124936009838 putative substrate-binding site; other site 1124936009839 nickel binding site [ion binding]; other site 1124936009840 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 1124936009841 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1124936009842 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1124936009843 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1124936009844 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1124936009845 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1124936009846 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1124936009847 active site 1124936009848 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124936009849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936009850 DNA-binding site [nucleotide binding]; DNA binding site 1124936009851 FCD domain; Region: FCD; pfam07729 1124936009852 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1124936009853 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1124936009854 putative NAD(P) binding site [chemical binding]; other site 1124936009855 catalytic Zn binding site [ion binding]; other site 1124936009856 structural Zn binding site [ion binding]; other site 1124936009857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009858 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936009859 putative substrate translocation pore; other site 1124936009860 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 1124936009861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124936009862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936009864 putative substrate translocation pore; other site 1124936009865 hypothetical protein; Provisional; Region: PRK06184 1124936009866 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124936009867 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124936009868 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1124936009869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936009870 putative DNA binding site [nucleotide binding]; other site 1124936009871 putative Zn2+ binding site [ion binding]; other site 1124936009872 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 1124936009873 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1124936009874 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1124936009875 homotrimer interaction site [polypeptide binding]; other site 1124936009876 putative active site [active] 1124936009877 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1124936009878 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1124936009879 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1124936009880 potential frameshift: common BLAST hit: gi|379700723|ref|YP_005242451.1| putative cytoplasmic protein 1124936009881 Winged helix-turn helix; Region: HTH_29; pfam13551 1124936009882 Helix-turn-helix domain; Region: HTH_28; pfam13518 1124936009883 Homeodomain-like domain; Region: HTH_32; pfam13565 1124936009884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936009885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936009886 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1124936009887 putative effector binding pocket; other site 1124936009888 putative dimerization interface [polypeptide binding]; other site 1124936009889 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1124936009890 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1124936009891 FMN binding site [chemical binding]; other site 1124936009892 substrate binding site [chemical binding]; other site 1124936009893 putative catalytic residue [active] 1124936009894 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124936009895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936009896 DNA binding site [nucleotide binding] 1124936009897 domain linker motif; other site 1124936009898 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1124936009899 dimerization interface (closed form) [polypeptide binding]; other site 1124936009900 ligand binding site [chemical binding]; other site 1124936009901 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1124936009902 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1124936009903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936009904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936009905 homodimer interface [polypeptide binding]; other site 1124936009906 catalytic residue [active] 1124936009907 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1124936009908 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1124936009909 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1124936009910 active site 1124936009911 catalytic site [active] 1124936009912 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1124936009913 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1124936009914 active site 1124936009915 catalytic site [active] 1124936009916 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1124936009917 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1124936009918 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1124936009919 catalytic site [active] 1124936009920 active site 1124936009921 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1124936009922 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1124936009923 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1124936009924 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1124936009925 biofilm-dependent modulation protein; Provisional; Region: PRK11436 1124936009926 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1124936009927 malate dehydrogenase; Provisional; Region: PRK13529 1124936009928 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1124936009929 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1124936009930 NAD(P) binding site [chemical binding]; other site 1124936009931 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1124936009932 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1124936009933 NAD binding site [chemical binding]; other site 1124936009934 substrate binding site [chemical binding]; other site 1124936009935 catalytic Zn binding site [ion binding]; other site 1124936009936 tetramer interface [polypeptide binding]; other site 1124936009937 structural Zn binding site [ion binding]; other site 1124936009938 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1124936009939 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1124936009940 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1124936009941 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1124936009942 potential frameshift: common BLAST hit: gi|379700741|ref|YP_005242469.1| formate dehydrogenase-N subunit alpha 1124936009943 aromatic amino acid exporter; Provisional; Region: PRK11689 1124936009944 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936009945 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936009946 trimer interface [polypeptide binding]; other site 1124936009947 eyelet of channel; other site 1124936009948 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1124936009949 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1124936009950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936009951 putative substrate translocation pore; other site 1124936009952 TetR family transcriptional regulator; Provisional; Region: PRK14996 1124936009953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936009954 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1124936009955 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1124936009956 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1124936009957 [4Fe-4S] binding site [ion binding]; other site 1124936009958 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936009959 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936009960 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936009961 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1124936009962 molybdopterin cofactor binding site; other site 1124936009963 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1124936009964 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1124936009965 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1124936009966 hypothetical protein; Provisional; Region: PRK10281 1124936009967 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1124936009968 L-asparagine permease; Provisional; Region: PRK15049 1124936009969 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124936009970 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1124936009971 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1124936009972 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124936009973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936009974 N-terminal plug; other site 1124936009975 ligand-binding site [chemical binding]; other site 1124936009976 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1124936009977 DNA-binding site [nucleotide binding]; DNA binding site 1124936009978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1124936009979 FCD domain; Region: FCD; pfam07729 1124936009980 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1124936009981 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1124936009982 NAD(P) binding site [chemical binding]; other site 1124936009983 substrate binding site [chemical binding]; other site 1124936009984 dimer interface [polypeptide binding]; other site 1124936009985 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1124936009986 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124936009987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1124936009988 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1124936009989 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1124936009990 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1124936009991 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1124936009992 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1124936009993 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1124936009994 tetrameric interface [polypeptide binding]; other site 1124936009995 NAD binding site [chemical binding]; other site 1124936009996 catalytic residues [active] 1124936009997 substrate binding site [chemical binding]; other site 1124936009998 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124936009999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936010000 DNA-binding site [nucleotide binding]; DNA binding site 1124936010001 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936010002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936010003 homodimer interface [polypeptide binding]; other site 1124936010004 catalytic residue [active] 1124936010005 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 1124936010006 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 1124936010007 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1124936010008 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1124936010009 Peptidase family U32; Region: Peptidase_U32; pfam01136 1124936010010 Collagenase; Region: DUF3656; pfam12392 1124936010011 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124936010012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936010013 non-specific DNA binding site [nucleotide binding]; other site 1124936010014 salt bridge; other site 1124936010015 sequence-specific DNA binding site [nucleotide binding]; other site 1124936010016 Cupin domain; Region: Cupin_2; pfam07883 1124936010017 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1124936010018 benzoate transporter; Region: benE; TIGR00843 1124936010019 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1124936010020 tellurite resistance protein TehB; Provisional; Region: PRK11207 1124936010021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936010022 S-adenosylmethionine binding site [chemical binding]; other site 1124936010023 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1124936010024 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1124936010025 gating phenylalanine in ion channel; other site 1124936010026 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1124936010027 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1124936010028 putative trimer interface [polypeptide binding]; other site 1124936010029 putative CoA binding site [chemical binding]; other site 1124936010030 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1124936010031 putative trimer interface [polypeptide binding]; other site 1124936010032 putative CoA binding site [chemical binding]; other site 1124936010033 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1124936010034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936010035 Coenzyme A binding pocket [chemical binding]; other site 1124936010036 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1124936010037 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1124936010038 oligomer interface [polypeptide binding]; other site 1124936010039 active site 1124936010040 metal binding site [ion binding]; metal-binding site 1124936010041 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1124936010042 active site 1124936010043 P-loop; other site 1124936010044 phosphorylation site [posttranslational modification] 1124936010045 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1124936010046 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1124936010047 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1124936010048 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936010049 active site 1124936010050 phosphorylation site [posttranslational modification] 1124936010051 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1124936010052 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1124936010053 substrate binding site [chemical binding]; other site 1124936010054 hexamer interface [polypeptide binding]; other site 1124936010055 metal binding site [ion binding]; metal-binding site 1124936010056 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936010057 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124936010058 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936010059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936010060 Coenzyme A binding pocket [chemical binding]; other site 1124936010061 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1124936010062 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1124936010063 teramer interface [polypeptide binding]; other site 1124936010064 active site 1124936010065 FMN binding site [chemical binding]; other site 1124936010066 catalytic residues [active] 1124936010067 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1124936010068 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1124936010069 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1124936010070 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1124936010071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1124936010072 substrate binding pocket [chemical binding]; other site 1124936010073 catalytic triad [active] 1124936010074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1124936010075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1124936010076 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1124936010077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936010078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936010079 dimerization interface [polypeptide binding]; other site 1124936010080 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1124936010081 dimer interface [polypeptide binding]; other site 1124936010082 ligand binding site [chemical binding]; other site 1124936010083 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1124936010084 HAMP domain; Region: HAMP; pfam00672 1124936010085 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936010086 dimer interface [polypeptide binding]; other site 1124936010087 putative CheW interface [polypeptide binding]; other site 1124936010088 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1124936010089 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1124936010090 substrate binding site [chemical binding]; other site 1124936010091 catalytic Zn binding site [ion binding]; other site 1124936010092 NAD binding site [chemical binding]; other site 1124936010093 structural Zn binding site [ion binding]; other site 1124936010094 dimer interface [polypeptide binding]; other site 1124936010095 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1124936010096 putative metal binding site [ion binding]; other site 1124936010097 putative homodimer interface [polypeptide binding]; other site 1124936010098 putative homotetramer interface [polypeptide binding]; other site 1124936010099 putative homodimer-homodimer interface [polypeptide binding]; other site 1124936010100 putative allosteric switch controlling residues; other site 1124936010101 Sif protein; Region: Sif; cl11505 1124936010102 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1124936010103 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1124936010104 active site 1124936010105 catalytic triad [active] 1124936010106 oxyanion hole [active] 1124936010107 Predicted membrane protein [Function unknown]; Region: COG3326 1124936010108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936010109 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124936010110 substrate binding pocket [chemical binding]; other site 1124936010111 membrane-bound complex binding site; other site 1124936010112 hinge residues; other site 1124936010113 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936010114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936010115 dimer interface [polypeptide binding]; other site 1124936010116 conserved gate region; other site 1124936010117 putative PBP binding loops; other site 1124936010118 ABC-ATPase subunit interface; other site 1124936010119 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124936010120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936010121 Walker A/P-loop; other site 1124936010122 ATP binding site [chemical binding]; other site 1124936010123 Q-loop/lid; other site 1124936010124 ABC transporter signature motif; other site 1124936010125 Walker B; other site 1124936010126 D-loop; other site 1124936010127 H-loop/switch region; other site 1124936010128 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936010129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936010130 dimer interface [polypeptide binding]; other site 1124936010131 conserved gate region; other site 1124936010132 putative PBP binding loops; other site 1124936010133 ABC-ATPase subunit interface; other site 1124936010134 Predicted membrane protein [Function unknown]; Region: COG5305 1124936010135 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1124936010136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936010137 S-adenosylmethionine binding site [chemical binding]; other site 1124936010138 cytochrome b561; Provisional; Region: PRK11513 1124936010139 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1124936010140 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1124936010141 putative active site [active] 1124936010142 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1124936010143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936010144 ATP binding site [chemical binding]; other site 1124936010145 putative Mg++ binding site [ion binding]; other site 1124936010146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936010147 nucleotide binding region [chemical binding]; other site 1124936010148 ATP-binding site [chemical binding]; other site 1124936010149 Helicase associated domain (HA2); Region: HA2; pfam04408 1124936010150 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1124936010151 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1124936010152 azoreductase; Reviewed; Region: PRK00170 1124936010153 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124936010154 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1124936010155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1124936010156 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1124936010157 hypothetical protein; Provisional; Region: PRK10695 1124936010158 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1124936010159 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1124936010160 putative ligand binding site [chemical binding]; other site 1124936010161 putative NAD binding site [chemical binding]; other site 1124936010162 catalytic site [active] 1124936010163 heat-inducible protein; Provisional; Region: PRK10449 1124936010164 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1124936010165 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1124936010166 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1124936010167 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1124936010168 dimer interface [polypeptide binding]; other site 1124936010169 PYR/PP interface [polypeptide binding]; other site 1124936010170 TPP binding site [chemical binding]; other site 1124936010171 substrate binding site [chemical binding]; other site 1124936010172 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1124936010173 Domain of unknown function; Region: EKR; smart00890 1124936010174 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1124936010175 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936010176 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1124936010177 TPP-binding site [chemical binding]; other site 1124936010178 dimer interface [polypeptide binding]; other site 1124936010179 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124936010180 Ligand Binding Site [chemical binding]; other site 1124936010181 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1124936010182 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1124936010183 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1124936010184 Ligand Binding Site [chemical binding]; other site 1124936010185 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1124936010186 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124936010187 ATP binding site [chemical binding]; other site 1124936010188 Mg++ binding site [ion binding]; other site 1124936010189 motif III; other site 1124936010190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936010191 nucleotide binding region [chemical binding]; other site 1124936010192 ATP-binding site [chemical binding]; other site 1124936010193 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1124936010194 putative RNA binding site [nucleotide binding]; other site 1124936010195 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1124936010196 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1124936010197 Cl binding site [ion binding]; other site 1124936010198 oligomer interface [polypeptide binding]; other site 1124936010199 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124936010200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936010201 dimer interface [polypeptide binding]; other site 1124936010202 putative CheW interface [polypeptide binding]; other site 1124936010203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1124936010204 Smr domain; Region: Smr; pfam01713 1124936010205 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1124936010206 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1124936010207 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124936010208 DNA binding site [nucleotide binding] 1124936010209 active site 1124936010210 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1124936010211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124936010212 ligand binding site [chemical binding]; other site 1124936010213 flexible hinge region; other site 1124936010214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1124936010215 putative switch regulator; other site 1124936010216 non-specific DNA interactions [nucleotide binding]; other site 1124936010217 DNA binding site [nucleotide binding] 1124936010218 sequence specific DNA binding site [nucleotide binding]; other site 1124936010219 putative cAMP binding site [chemical binding]; other site 1124936010220 universal stress protein UspE; Provisional; Region: PRK11175 1124936010221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124936010222 Ligand Binding Site [chemical binding]; other site 1124936010223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124936010224 Ligand Binding Site [chemical binding]; other site 1124936010225 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1124936010226 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124936010227 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124936010228 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1124936010229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936010230 non-specific DNA binding site [nucleotide binding]; other site 1124936010231 salt bridge; other site 1124936010232 sequence-specific DNA binding site [nucleotide binding]; other site 1124936010233 Cupin domain; Region: Cupin_2; pfam07883 1124936010234 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1124936010235 B3/4 domain; Region: B3_4; pfam03483 1124936010236 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1124936010237 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1124936010238 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1124936010239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936010240 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1124936010241 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124936010242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124936010243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936010244 oxidoreductase; Provisional; Region: PRK12742 1124936010245 classical (c) SDRs; Region: SDR_c; cd05233 1124936010246 NAD(P) binding site [chemical binding]; other site 1124936010247 active site 1124936010248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936010249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936010250 active site 1124936010251 catalytic tetrad [active] 1124936010252 potential frameshift: common BLAST hit: gi|386591517|ref|YP_006087917.1| LysR family transcriptional regulator YcjZ 1124936010253 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1124936010254 NmrA-like family; Region: NmrA; pfam05368 1124936010255 NAD(P) binding site [chemical binding]; other site 1124936010256 active site lysine 1124936010257 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1124936010258 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1124936010259 peptide binding site [polypeptide binding]; other site 1124936010260 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1124936010261 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1124936010262 putative active site [active] 1124936010263 Zn binding site [ion binding]; other site 1124936010264 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1124936010265 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1124936010266 active site 1124936010267 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1124936010268 dimer interface [polypeptide binding]; other site 1124936010269 catalytic triad [active] 1124936010270 peroxidatic and resolving cysteines [active] 1124936010271 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1124936010272 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1124936010273 putative aromatic amino acid binding site; other site 1124936010274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936010275 Walker A motif; other site 1124936010276 ATP binding site [chemical binding]; other site 1124936010277 Walker B motif; other site 1124936010278 arginine finger; other site 1124936010279 hypothetical protein; Provisional; Region: PRK05415 1124936010280 TIGR01620 family protein; Region: hyp_HI0043 1124936010281 Predicted ATPase [General function prediction only]; Region: COG3106 1124936010282 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1124936010283 active site residue [active] 1124936010284 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1124936010285 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1124936010286 phage shock protein C; Region: phageshock_pspC; TIGR02978 1124936010287 phage shock protein B; Provisional; Region: pspB; PRK09458 1124936010288 phage shock protein PspA; Provisional; Region: PRK10698 1124936010289 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1124936010290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936010291 Walker A motif; other site 1124936010292 ATP binding site [chemical binding]; other site 1124936010293 Walker B motif; other site 1124936010294 arginine finger; other site 1124936010295 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1124936010296 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1124936010297 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1124936010298 peptide binding site [polypeptide binding]; other site 1124936010299 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1124936010300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936010301 dimer interface [polypeptide binding]; other site 1124936010302 conserved gate region; other site 1124936010303 putative PBP binding loops; other site 1124936010304 ABC-ATPase subunit interface; other site 1124936010305 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1124936010306 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1124936010307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936010308 dimer interface [polypeptide binding]; other site 1124936010309 conserved gate region; other site 1124936010310 putative PBP binding loops; other site 1124936010311 ABC-ATPase subunit interface; other site 1124936010312 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1124936010313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936010314 Walker A/P-loop; other site 1124936010315 ATP binding site [chemical binding]; other site 1124936010316 Q-loop/lid; other site 1124936010317 ABC transporter signature motif; other site 1124936010318 Walker B; other site 1124936010319 D-loop; other site 1124936010320 H-loop/switch region; other site 1124936010321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124936010322 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1124936010323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936010324 Walker A/P-loop; other site 1124936010325 ATP binding site [chemical binding]; other site 1124936010326 Q-loop/lid; other site 1124936010327 ABC transporter signature motif; other site 1124936010328 Walker B; other site 1124936010329 D-loop; other site 1124936010330 H-loop/switch region; other site 1124936010331 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1124936010332 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1124936010333 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1124936010334 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1124936010335 NAD binding site [chemical binding]; other site 1124936010336 homotetramer interface [polypeptide binding]; other site 1124936010337 homodimer interface [polypeptide binding]; other site 1124936010338 substrate binding site [chemical binding]; other site 1124936010339 active site 1124936010340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1124936010341 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1124936010342 exoribonuclease II; Provisional; Region: PRK05054 1124936010343 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1124936010344 RNB domain; Region: RNB; pfam00773 1124936010345 S1 RNA binding domain; Region: S1; pfam00575 1124936010346 RNase II stability modulator; Provisional; Region: PRK10060 1124936010347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936010348 putative active site [active] 1124936010349 heme pocket [chemical binding]; other site 1124936010350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936010351 metal binding site [ion binding]; metal-binding site 1124936010352 active site 1124936010353 I-site; other site 1124936010354 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936010355 hypothetical protein; Provisional; Region: PRK13658 1124936010356 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936010357 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936010358 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936010359 lipoprotein; Provisional; Region: PRK10540 1124936010360 translation initiation factor Sui1; Validated; Region: PRK06824 1124936010361 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1124936010362 putative rRNA binding site [nucleotide binding]; other site 1124936010363 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1124936010364 active site 1124936010365 dimer interface [polypeptide binding]; other site 1124936010366 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1124936010367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1124936010368 TPR motif; other site 1124936010369 binding surface 1124936010370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124936010371 binding surface 1124936010372 TPR motif; other site 1124936010373 Predicted membrane protein [Function unknown]; Region: COG3771 1124936010374 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124936010375 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1124936010376 active site 1124936010377 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1124936010378 dimerization interface [polypeptide binding]; other site 1124936010379 active site 1124936010380 aconitate hydratase; Validated; Region: PRK09277 1124936010381 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1124936010382 substrate binding site [chemical binding]; other site 1124936010383 ligand binding site [chemical binding]; other site 1124936010384 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1124936010385 substrate binding site [chemical binding]; other site 1124936010386 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1124936010387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936010388 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1124936010389 substrate binding site [chemical binding]; other site 1124936010390 putative dimerization interface [polypeptide binding]; other site 1124936010391 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1124936010392 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1124936010393 active site 1124936010394 interdomain interaction site; other site 1124936010395 putative metal-binding site [ion binding]; other site 1124936010396 nucleotide binding site [chemical binding]; other site 1124936010397 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1124936010398 domain I; other site 1124936010399 DNA binding groove [nucleotide binding] 1124936010400 phosphate binding site [ion binding]; other site 1124936010401 domain II; other site 1124936010402 domain III; other site 1124936010403 nucleotide binding site [chemical binding]; other site 1124936010404 catalytic site [active] 1124936010405 domain IV; other site 1124936010406 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124936010407 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124936010408 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1124936010409 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1124936010410 hypothetical protein; Provisional; Region: PRK11037 1124936010411 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1124936010412 putative inner membrane peptidase; Provisional; Region: PRK11778 1124936010413 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1124936010414 tandem repeat interface [polypeptide binding]; other site 1124936010415 oligomer interface [polypeptide binding]; other site 1124936010416 active site residues [active] 1124936010417 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1124936010418 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1124936010419 NADP binding site [chemical binding]; other site 1124936010420 homodimer interface [polypeptide binding]; other site 1124936010421 active site 1124936010422 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1124936010423 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1124936010424 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1124936010425 homodimer interface [polypeptide binding]; other site 1124936010426 Walker A motif; other site 1124936010427 ATP binding site [chemical binding]; other site 1124936010428 hydroxycobalamin binding site [chemical binding]; other site 1124936010429 Walker B motif; other site 1124936010430 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1124936010431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936010432 RNA binding surface [nucleotide binding]; other site 1124936010433 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1124936010434 probable active site [active] 1124936010435 hypothetical protein; Provisional; Region: PRK11630 1124936010436 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1124936010437 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1124936010438 active site 1124936010439 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1124936010440 anthranilate synthase component I; Provisional; Region: PRK13564 1124936010441 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1124936010442 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1124936010443 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1124936010444 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1124936010445 glutamine binding [chemical binding]; other site 1124936010446 catalytic triad [active] 1124936010447 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1124936010448 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1124936010449 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1124936010450 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1124936010451 active site 1124936010452 ribulose/triose binding site [chemical binding]; other site 1124936010453 phosphate binding site [ion binding]; other site 1124936010454 substrate (anthranilate) binding pocket [chemical binding]; other site 1124936010455 product (indole) binding pocket [chemical binding]; other site 1124936010456 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1124936010457 active site 1124936010458 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1124936010459 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1124936010460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936010461 catalytic residue [active] 1124936010462 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1124936010463 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1124936010464 substrate binding site [chemical binding]; other site 1124936010465 active site 1124936010466 catalytic residues [active] 1124936010467 heterodimer interface [polypeptide binding]; other site 1124936010468 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1124936010469 dimerization interface [polypeptide binding]; other site 1124936010470 metal binding site [ion binding]; metal-binding site 1124936010471 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1124936010472 dinuclear metal binding motif [ion binding]; other site 1124936010473 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1124936010474 dimanganese center [ion binding]; other site 1124936010475 outer membrane protein W; Provisional; Region: PRK10959 1124936010476 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1124936010477 hypothetical protein; Provisional; Region: PRK02868 1124936010478 intracellular septation protein A; Reviewed; Region: PRK00259 1124936010479 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1124936010480 transport protein TonB; Provisional; Region: PRK10819 1124936010481 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1124936010482 YciI-like protein; Reviewed; Region: PRK11370 1124936010483 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1124936010484 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1124936010485 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1124936010486 putative active site [active] 1124936010487 catalytic site [active] 1124936010488 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1124936010489 putative active site [active] 1124936010490 catalytic site [active] 1124936010491 dsDNA-mimic protein; Reviewed; Region: PRK05094 1124936010492 Ion transport protein; Region: Ion_trans; pfam00520 1124936010493 Ion channel; Region: Ion_trans_2; pfam07885 1124936010494 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1124936010495 Double zinc ribbon; Region: DZR; pfam12773 1124936010496 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1124936010497 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936010498 Walker A/P-loop; other site 1124936010499 ATP binding site [chemical binding]; other site 1124936010500 Q-loop/lid; other site 1124936010501 ABC transporter signature motif; other site 1124936010502 Walker B; other site 1124936010503 D-loop; other site 1124936010504 H-loop/switch region; other site 1124936010505 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1124936010506 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1124936010507 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936010508 Walker A/P-loop; other site 1124936010509 ATP binding site [chemical binding]; other site 1124936010510 Q-loop/lid; other site 1124936010511 ABC transporter signature motif; other site 1124936010512 Walker B; other site 1124936010513 D-loop; other site 1124936010514 H-loop/switch region; other site 1124936010515 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124936010516 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1124936010517 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1124936010518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936010519 dimer interface [polypeptide binding]; other site 1124936010520 conserved gate region; other site 1124936010521 ABC-ATPase subunit interface; other site 1124936010522 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1124936010523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936010524 dimer interface [polypeptide binding]; other site 1124936010525 conserved gate region; other site 1124936010526 putative PBP binding loops; other site 1124936010527 ABC-ATPase subunit interface; other site 1124936010528 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1124936010529 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1124936010530 peptide binding site [polypeptide binding]; other site 1124936010531 hypothetical protein; Provisional; Region: PRK11111 1124936010532 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1124936010533 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1124936010534 putative catalytic cysteine [active] 1124936010535 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1124936010536 putative active site [active] 1124936010537 metal binding site [ion binding]; metal-binding site 1124936010538 thymidine kinase; Provisional; Region: PRK04296 1124936010539 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1124936010540 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1124936010541 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1124936010542 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1124936010543 active site 1124936010544 tetramer interface; other site 1124936010545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936010546 active site 1124936010547 response regulator of RpoS; Provisional; Region: PRK10693 1124936010548 phosphorylation site [posttranslational modification] 1124936010549 intermolecular recognition site; other site 1124936010550 dimerization interface [polypeptide binding]; other site 1124936010551 hypothetical protein; Provisional; Region: PRK10279 1124936010552 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1124936010553 active site 1124936010554 nucleophile elbow; other site 1124936010555 SEC-C motif; Region: SEC-C; pfam02810 1124936010556 hypothetical protein; Provisional; Region: PRK04233 1124936010557 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1124936010558 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1124936010559 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1124936010560 putative active site [active] 1124936010561 putative substrate binding site [chemical binding]; other site 1124936010562 putative cosubstrate binding site; other site 1124936010563 catalytic site [active] 1124936010564 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936010565 Sel1-like repeats; Region: SEL1; smart00671 1124936010566 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936010567 Sel1-like repeats; Region: SEL1; smart00671 1124936010568 Sel1-like repeats; Region: SEL1; smart00671 1124936010569 Sel1-like repeats; Region: SEL1; smart00671 1124936010570 Sel1-like repeats; Region: SEL1; smart00671 1124936010571 Sel1-like repeats; Region: SEL1; smart00671 1124936010572 Sel1-like repeats; Region: SEL1; smart00671 1124936010573 Sel1-like repeats; Region: SEL1; smart00671 1124936010574 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1124936010575 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1124936010576 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1124936010577 4Fe-4S binding domain; Region: Fer4; cl02805 1124936010578 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1124936010579 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1124936010580 [4Fe-4S] binding site [ion binding]; other site 1124936010581 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936010582 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936010583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936010584 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1124936010585 molybdopterin cofactor binding site; other site 1124936010586 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1124936010587 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1124936010588 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1124936010589 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936010590 dimerization interface [polypeptide binding]; other site 1124936010591 Histidine kinase; Region: HisKA_3; pfam07730 1124936010592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936010593 ATP binding site [chemical binding]; other site 1124936010594 Mg2+ binding site [ion binding]; other site 1124936010595 G-X-G motif; other site 1124936010596 transcriptional regulator NarL; Provisional; Region: PRK10651 1124936010597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936010598 active site 1124936010599 phosphorylation site [posttranslational modification] 1124936010600 intermolecular recognition site; other site 1124936010601 dimerization interface [polypeptide binding]; other site 1124936010602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936010603 DNA binding residues [nucleotide binding] 1124936010604 dimerization interface [polypeptide binding]; other site 1124936010605 putative invasin; Provisional; Region: PRK10177 1124936010606 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1124936010607 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1124936010608 cation transport regulator; Reviewed; Region: chaB; PRK09582 1124936010609 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1124936010610 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1124936010611 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1124936010612 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124936010613 hypothetical protein; Provisional; Region: PRK10941 1124936010614 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1124936010615 hypothetical protein; Provisional; Region: PRK10278 1124936010616 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1124936010617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936010618 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1124936010619 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1124936010620 RF-1 domain; Region: RF-1; pfam00472 1124936010621 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1124936010622 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1124936010623 tRNA; other site 1124936010624 putative tRNA binding site [nucleotide binding]; other site 1124936010625 putative NADP binding site [chemical binding]; other site 1124936010626 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1124936010627 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1124936010628 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1124936010629 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1124936010630 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1124936010631 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1124936010632 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1124936010633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936010634 active site 1124936010635 putative transporter; Provisional; Region: PRK11660 1124936010636 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1124936010637 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124936010638 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1124936010639 hypothetical protein; Provisional; Region: PRK10692 1124936010640 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1124936010641 putative active site [active] 1124936010642 catalytic residue [active] 1124936010643 GTP-binding protein YchF; Reviewed; Region: PRK09601 1124936010644 YchF GTPase; Region: YchF; cd01900 1124936010645 G1 box; other site 1124936010646 GTP/Mg2+ binding site [chemical binding]; other site 1124936010647 Switch I region; other site 1124936010648 G2 box; other site 1124936010649 Switch II region; other site 1124936010650 G3 box; other site 1124936010651 G4 box; other site 1124936010652 G5 box; other site 1124936010653 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1124936010654 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 1124936010655 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 1124936010656 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1124936010657 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1124936010658 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1124936010659 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1124936010660 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1124936010661 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1124936010662 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1124936010663 putative substrate-binding site; other site 1124936010664 nickel binding site [ion binding]; other site 1124936010665 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1124936010666 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1124936010667 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1124936010668 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1124936010669 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1124936010670 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1124936010671 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1124936010672 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1124936010673 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1124936010674 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1124936010675 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1124936010676 NAD(P) binding site [chemical binding]; other site 1124936010677 trehalase; Provisional; Region: treA; PRK13271 1124936010678 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1124936010679 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1124936010680 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1124936010681 Flagellar regulator YcgR; Region: YcgR; pfam07317 1124936010682 PilZ domain; Region: PilZ; pfam07238 1124936010683 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1124936010684 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936010685 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936010686 catalytic residue [active] 1124936010687 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1124936010688 dimer interface [polypeptide binding]; other site 1124936010689 catalytic triad [active] 1124936010690 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1124936010691 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1124936010692 TrkA-C domain; Region: TrkA_C; pfam02080 1124936010693 Transporter associated domain; Region: CorC_HlyC; smart01091 1124936010694 alanine racemase; Reviewed; Region: dadX; PRK03646 1124936010695 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1124936010696 active site 1124936010697 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936010698 substrate binding site [chemical binding]; other site 1124936010699 catalytic residues [active] 1124936010700 dimer interface [polypeptide binding]; other site 1124936010701 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1124936010702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124936010703 SpoVR family protein; Provisional; Region: PRK11767 1124936010704 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1124936010705 fatty acid metabolism regulator; Provisional; Region: PRK04984 1124936010706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936010707 DNA-binding site [nucleotide binding]; DNA binding site 1124936010708 FadR C-terminal domain; Region: FadR_C; pfam07840 1124936010709 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1124936010710 transmembrane helices; other site 1124936010711 disulfide bond formation protein B; Provisional; Region: PRK01749 1124936010712 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1124936010713 GnsA/GnsB family; Region: GnsAB; pfam08178 1124936010714 hypothetical protein; Provisional; Region: PRK05170 1124936010715 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1124936010716 hypothetical protein; Provisional; Region: PRK10691 1124936010717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1124936010718 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1124936010719 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1124936010720 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1124936010721 cell division inhibitor MinD; Provisional; Region: PRK10818 1124936010722 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1124936010723 Switch I; other site 1124936010724 Switch II; other site 1124936010725 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1124936010726 ribonuclease D; Provisional; Region: PRK10829 1124936010727 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1124936010728 catalytic site [active] 1124936010729 putative active site [active] 1124936010730 putative substrate binding site [chemical binding]; other site 1124936010731 HRDC domain; Region: HRDC; cl02578 1124936010732 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1124936010733 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1124936010734 acyl-activating enzyme (AAE) consensus motif; other site 1124936010735 putative AMP binding site [chemical binding]; other site 1124936010736 putative active site [active] 1124936010737 putative CoA binding site [chemical binding]; other site 1124936010738 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1124936010739 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1124936010740 Glycoprotease family; Region: Peptidase_M22; pfam00814 1124936010741 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1124936010742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1124936010743 DEAD_2; Region: DEAD_2; pfam06733 1124936010744 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1124936010745 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1124936010746 homotrimer interaction site [polypeptide binding]; other site 1124936010747 putative active site [active] 1124936010748 hypothetical protein; Provisional; Region: PRK05114 1124936010749 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1124936010750 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1124936010751 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1124936010752 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1124936010753 putative active site [active] 1124936010754 putative CoA binding site [chemical binding]; other site 1124936010755 nudix motif; other site 1124936010756 metal binding site [ion binding]; metal-binding site 1124936010757 L-serine deaminase; Provisional; Region: PRK15023 1124936010758 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124936010759 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124936010760 phage resistance protein; Provisional; Region: PRK10551 1124936010761 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124936010762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936010763 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1124936010764 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1124936010765 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124936010766 Transporter associated domain; Region: CorC_HlyC; smart01091 1124936010767 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1124936010768 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1124936010769 active pocket/dimerization site; other site 1124936010770 active site 1124936010771 phosphorylation site [posttranslational modification] 1124936010772 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1124936010773 active site 1124936010774 phosphorylation site [posttranslational modification] 1124936010775 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1124936010776 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1124936010777 hypothetical protein; Provisional; Region: PRK02913 1124936010778 hypothetical protein; Provisional; Region: PRK11469 1124936010779 Domain of unknown function DUF; Region: DUF204; pfam02659 1124936010780 Domain of unknown function DUF; Region: DUF204; pfam02659 1124936010781 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1124936010782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936010783 S-adenosylmethionine binding site [chemical binding]; other site 1124936010784 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1124936010785 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124936010786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124936010787 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124936010788 DNA-binding site [nucleotide binding]; DNA binding site 1124936010789 RNA-binding motif; other site 1124936010790 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1124936010791 YebO-like protein; Region: YebO; pfam13974 1124936010792 PhoPQ regulatory protein; Provisional; Region: PRK10299 1124936010793 YobH-like protein; Region: YobH; pfam13996 1124936010794 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1124936010795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936010796 dimerization interface [polypeptide binding]; other site 1124936010797 putative Zn2+ binding site [ion binding]; other site 1124936010798 putative DNA binding site [nucleotide binding]; other site 1124936010799 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124936010800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936010801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936010802 putative substrate translocation pore; other site 1124936010803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936010804 heat shock protein HtpX; Provisional; Region: PRK05457 1124936010805 carboxy-terminal protease; Provisional; Region: PRK11186 1124936010806 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1124936010807 protein binding site [polypeptide binding]; other site 1124936010808 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1124936010809 Catalytic dyad [active] 1124936010810 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1124936010811 ProP expression regulator; Provisional; Region: PRK04950 1124936010812 ProQ/FINO family; Region: ProQ; pfam04352 1124936010813 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1124936010814 GAF domain; Region: GAF_2; pfam13185 1124936010815 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1124936010816 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124936010817 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124936010818 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1124936010819 mce related protein; Region: MCE; pfam02470 1124936010820 mce related protein; Region: MCE; pfam02470 1124936010821 mce related protein; Region: MCE; pfam02470 1124936010822 mce related protein; Region: MCE; pfam02470 1124936010823 mce related protein; Region: MCE; pfam02470 1124936010824 mce related protein; Region: MCE; pfam02470 1124936010825 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1124936010826 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1124936010827 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1124936010828 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1124936010829 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1124936010830 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1124936010831 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124936010832 type III secretion protein SopE2; Provisional; Region: PRK15280 1124936010833 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1124936010834 SopE GEF domain; Region: SopE_GEF; pfam07487 1124936010835 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1124936010836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936010837 Coenzyme A binding pocket [chemical binding]; other site 1124936010838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1124936010839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1124936010840 MULE transposase domain; Region: MULE; pfam10551 1124936010841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936010842 DNA binding site [nucleotide binding] 1124936010843 active site 1124936010844 Int/Topo IB signature motif; other site 1124936010845 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1124936010846 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124936010847 EamA-like transporter family; Region: EamA; pfam00892 1124936010848 EamA-like transporter family; Region: EamA; pfam00892 1124936010849 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1124936010850 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1124936010851 DNA-binding interface [nucleotide binding]; DNA binding site 1124936010852 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1124936010853 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1124936010854 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1124936010855 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1124936010856 ADP-ribose binding site [chemical binding]; other site 1124936010857 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1124936010858 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1124936010859 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1124936010860 exonuclease VIII; Reviewed; Region: PRK09709 1124936010861 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936010862 DNA binding site [nucleotide binding] 1124936010863 active site 1124936010864 Int/Topo IB signature motif; other site 1124936010865 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1124936010866 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1124936010867 hypothetical protein; Provisional; Region: PRK10301 1124936010868 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1124936010869 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124936010870 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1124936010871 exodeoxyribonuclease X; Provisional; Region: PRK07983 1124936010872 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1124936010873 active site 1124936010874 catalytic site [active] 1124936010875 substrate binding site [chemical binding]; other site 1124936010876 protease 2; Provisional; Region: PRK10115 1124936010877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124936010878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1124936010879 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1124936010880 putative metal binding site [ion binding]; other site 1124936010881 hypothetical protein; Provisional; Region: PRK13680 1124936010882 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1124936010883 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1124936010884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124936010885 ATP-grasp domain; Region: ATP-grasp; pfam02222 1124936010886 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1124936010887 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1124936010888 active site 1124936010889 intersubunit interface [polypeptide binding]; other site 1124936010890 catalytic residue [active] 1124936010891 phosphogluconate dehydratase; Validated; Region: PRK09054 1124936010892 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1124936010893 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1124936010894 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1124936010895 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1124936010896 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1124936010897 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124936010898 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124936010899 putative active site [active] 1124936010900 pyruvate kinase; Provisional; Region: PRK05826 1124936010901 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1124936010902 domain interfaces; other site 1124936010903 active site 1124936010904 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1124936010905 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1124936010906 putative acyl-acceptor binding pocket; other site 1124936010907 putative peptidase; Provisional; Region: PRK11649 1124936010908 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1124936010909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936010910 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124936010911 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1124936010912 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1124936010913 metal binding site [ion binding]; metal-binding site 1124936010914 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1124936010915 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1124936010916 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1124936010917 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936010918 ABC-ATPase subunit interface; other site 1124936010919 dimer interface [polypeptide binding]; other site 1124936010920 putative PBP binding regions; other site 1124936010921 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1124936010922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936010923 Walker A motif; other site 1124936010924 ATP binding site [chemical binding]; other site 1124936010925 Walker B motif; other site 1124936010926 arginine finger; other site 1124936010927 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1124936010928 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1124936010929 RuvA N terminal domain; Region: RuvA_N; pfam01330 1124936010930 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1124936010931 hypothetical protein; Provisional; Region: PRK11470 1124936010932 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1124936010933 active site 1124936010934 putative DNA-binding cleft [nucleotide binding]; other site 1124936010935 dimer interface [polypeptide binding]; other site 1124936010936 hypothetical protein; Validated; Region: PRK00110 1124936010937 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1124936010938 nudix motif; other site 1124936010939 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1124936010940 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1124936010941 dimer interface [polypeptide binding]; other site 1124936010942 anticodon binding site; other site 1124936010943 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1124936010944 homodimer interface [polypeptide binding]; other site 1124936010945 motif 1; other site 1124936010946 active site 1124936010947 motif 2; other site 1124936010948 GAD domain; Region: GAD; pfam02938 1124936010949 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1124936010950 active site 1124936010951 motif 3; other site 1124936010952 Isochorismatase family; Region: Isochorismatase; pfam00857 1124936010953 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1124936010954 catalytic triad [active] 1124936010955 conserved cis-peptide bond; other site 1124936010956 hypothetical protein; Provisional; Region: PRK10302 1124936010957 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1124936010958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936010959 S-adenosylmethionine binding site [chemical binding]; other site 1124936010960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936010961 S-adenosylmethionine binding site [chemical binding]; other site 1124936010962 copper homeostasis protein CutC; Provisional; Region: PRK11572 1124936010963 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1124936010964 putative metal binding site [ion binding]; other site 1124936010965 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1124936010966 arginyl-tRNA synthetase; Region: argS; TIGR00456 1124936010967 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1124936010968 active site 1124936010969 HIGH motif; other site 1124936010970 KMSK motif region; other site 1124936010971 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1124936010972 tRNA binding surface [nucleotide binding]; other site 1124936010973 anticodon binding site; other site 1124936010974 penicillin-binding protein 2; Provisional; Region: PRK10795 1124936010975 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124936010976 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124936010977 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1124936010978 Flagellar protein FlhE; Region: FlhE; pfam06366 1124936010979 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1124936010980 FHIPEP family; Region: FHIPEP; pfam00771 1124936010981 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1124936010982 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1124936010983 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1124936010984 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1124936010985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936010986 active site 1124936010987 phosphorylation site [posttranslational modification] 1124936010988 intermolecular recognition site; other site 1124936010989 dimerization interface [polypeptide binding]; other site 1124936010990 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1124936010991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936010992 active site 1124936010993 phosphorylation site [posttranslational modification] 1124936010994 intermolecular recognition site; other site 1124936010995 dimerization interface [polypeptide binding]; other site 1124936010996 CheB methylesterase; Region: CheB_methylest; pfam01339 1124936010997 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1124936010998 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1124936010999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936011000 S-adenosylmethionine binding site [chemical binding]; other site 1124936011001 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1124936011002 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1124936011003 dimer interface [polypeptide binding]; other site 1124936011004 ligand binding site [chemical binding]; other site 1124936011005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936011006 dimerization interface [polypeptide binding]; other site 1124936011007 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124936011008 dimer interface [polypeptide binding]; other site 1124936011009 putative CheW interface [polypeptide binding]; other site 1124936011010 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1124936011011 putative CheA interaction surface; other site 1124936011012 chemotaxis protein CheA; Provisional; Region: PRK10547 1124936011013 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124936011014 putative binding surface; other site 1124936011015 active site 1124936011016 CheY binding; Region: CheY-binding; pfam09078 1124936011017 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1124936011018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936011019 ATP binding site [chemical binding]; other site 1124936011020 Mg2+ binding site [ion binding]; other site 1124936011021 G-X-G motif; other site 1124936011022 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1124936011023 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1124936011024 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1124936011025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124936011026 ligand binding site [chemical binding]; other site 1124936011027 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1124936011028 flagellar motor protein MotA; Validated; Region: PRK09110 1124936011029 transcriptional activator FlhC; Provisional; Region: PRK12722 1124936011030 transcriptional activator FlhD; Provisional; Region: PRK02909 1124936011031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124936011032 Ligand Binding Site [chemical binding]; other site 1124936011033 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1124936011034 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1124936011035 active site 1124936011036 homotetramer interface [polypeptide binding]; other site 1124936011037 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1124936011038 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1124936011039 DJ-1 family protein; Region: not_thiJ; TIGR01383 1124936011040 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1124936011041 conserved cys residue [active] 1124936011042 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1124936011043 Ferritin-like domain; Region: Ferritin; pfam00210 1124936011044 ferroxidase diiron center [ion binding]; other site 1124936011045 hypothetical protein; Provisional; Region: PRK09273 1124936011046 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1124936011047 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1124936011048 YecR-like lipoprotein; Region: YecR; pfam13992 1124936011049 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1124936011050 Ferritin-like domain; Region: Ferritin; pfam00210 1124936011051 ferroxidase diiron center [ion binding]; other site 1124936011052 probable metal-binding protein; Region: matur_matur; TIGR03853 1124936011053 tyrosine transporter TyrP; Provisional; Region: PRK15132 1124936011054 aromatic amino acid transport protein; Region: araaP; TIGR00837 1124936011055 hypothetical protein; Provisional; Region: PRK10396 1124936011056 yecA family protein; Region: ygfB_yecA; TIGR02292 1124936011057 SEC-C motif; Region: SEC-C; pfam02810 1124936011058 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 1124936011059 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1124936011060 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1124936011061 NlpC/P60 family; Region: NLPC_P60; cl17555 1124936011062 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1124936011063 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1124936011064 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1124936011065 GIY-YIG motif/motif A; other site 1124936011066 active site 1124936011067 catalytic site [active] 1124936011068 putative DNA binding site [nucleotide binding]; other site 1124936011069 metal binding site [ion binding]; metal-binding site 1124936011070 UvrB/uvrC motif; Region: UVR; pfam02151 1124936011071 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1124936011072 Helix-hairpin-helix motif; Region: HHH; pfam00633 1124936011073 response regulator; Provisional; Region: PRK09483 1124936011074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936011075 active site 1124936011076 phosphorylation site [posttranslational modification] 1124936011077 intermolecular recognition site; other site 1124936011078 dimerization interface [polypeptide binding]; other site 1124936011079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936011080 DNA binding residues [nucleotide binding] 1124936011081 dimerization interface [polypeptide binding]; other site 1124936011082 hypothetical protein; Provisional; Region: PRK10613 1124936011083 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1124936011084 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1124936011085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936011086 DNA binding residues [nucleotide binding] 1124936011087 dimerization interface [polypeptide binding]; other site 1124936011088 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1124936011089 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124936011090 Walker A/P-loop; other site 1124936011091 ATP binding site [chemical binding]; other site 1124936011092 Q-loop/lid; other site 1124936011093 ABC transporter signature motif; other site 1124936011094 Walker B; other site 1124936011095 D-loop; other site 1124936011096 H-loop/switch region; other site 1124936011097 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124936011098 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936011099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936011100 dimer interface [polypeptide binding]; other site 1124936011101 conserved gate region; other site 1124936011102 putative PBP binding loops; other site 1124936011103 ABC-ATPase subunit interface; other site 1124936011104 D-cysteine desulfhydrase; Validated; Region: PRK03910 1124936011105 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1124936011106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936011107 catalytic residue [active] 1124936011108 cystine transporter subunit; Provisional; Region: PRK11260 1124936011109 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936011110 substrate binding pocket [chemical binding]; other site 1124936011111 membrane-bound complex binding site; other site 1124936011112 hinge residues; other site 1124936011113 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1124936011114 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1124936011115 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124936011116 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1124936011117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124936011118 DNA binding residues [nucleotide binding] 1124936011119 flagellin; Validated; Region: PRK08026 1124936011120 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1124936011121 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1124936011122 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1124936011123 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1124936011124 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1124936011125 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1124936011126 flagellar protein FliS; Validated; Region: fliS; PRK05685 1124936011127 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1124936011128 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1124936011129 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1124936011130 active site 1124936011131 Na/Ca binding site [ion binding]; other site 1124936011132 catalytic site [active] 1124936011133 lipoprotein; Provisional; Region: PRK10397 1124936011134 putative inner membrane protein; Provisional; Region: PRK11099 1124936011135 Sulphur transport; Region: Sulf_transp; pfam04143 1124936011136 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1124936011137 CPxP motif; other site 1124936011138 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1124936011139 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1124936011140 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1124936011141 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1124936011142 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1124936011143 FliG C-terminal domain; Region: FliG_C; pfam01706 1124936011144 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1124936011145 Flagellar assembly protein FliH; Region: FliH; pfam02108 1124936011146 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1124936011147 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1124936011148 Walker A motif/ATP binding site; other site 1124936011149 Walker B motif; other site 1124936011150 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1124936011151 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1124936011152 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1124936011153 flagellar hook-length control protein; Provisional; Region: PRK10118 1124936011154 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1124936011155 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1124936011156 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1124936011157 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1124936011158 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1124936011159 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1124936011160 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1124936011161 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1124936011162 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1124936011163 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1124936011164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936011165 DNA binding residues [nucleotide binding] 1124936011166 dimerization interface [polypeptide binding]; other site 1124936011167 hypothetical protein; Provisional; Region: PRK10708 1124936011168 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1124936011169 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1124936011170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936011171 active site 1124936011172 motif I; other site 1124936011173 motif II; other site 1124936011174 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1124936011175 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936011176 metal binding site [ion binding]; metal-binding site 1124936011177 active site 1124936011178 I-site; other site 1124936011179 Uncharacterized small protein [Function unknown]; Region: COG5475 1124936011180 hypothetical protein; Provisional; Region: PRK10062 1124936011181 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1124936011182 EamA-like transporter family; Region: EamA; pfam00892 1124936011183 EamA-like transporter family; Region: EamA; pfam00892 1124936011184 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1124936011185 additional DNA contacts [nucleotide binding]; other site 1124936011186 mismatch recognition site; other site 1124936011187 active site 1124936011188 zinc binding site [ion binding]; other site 1124936011189 DNA intercalation site [nucleotide binding]; other site 1124936011190 DNA cytosine methylase; Provisional; Region: PRK10458 1124936011191 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1124936011192 cofactor binding site; other site 1124936011193 DNA binding site [nucleotide binding] 1124936011194 substrate interaction site [chemical binding]; other site 1124936011195 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1124936011196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124936011197 Zn2+ binding site [ion binding]; other site 1124936011198 Mg2+ binding site [ion binding]; other site 1124936011199 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936011200 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936011201 trimer interface [polypeptide binding]; other site 1124936011202 eyelet of channel; other site 1124936011203 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124936011204 DNA-binding site [nucleotide binding]; DNA binding site 1124936011205 RNA-binding motif; other site 1124936011206 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1124936011207 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1124936011208 active site 1124936011209 DNA binding site [nucleotide binding] 1124936011210 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1124936011211 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1124936011212 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124936011213 Catalytic site [active] 1124936011214 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1124936011215 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1124936011216 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936011217 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1124936011218 putative protease; Region: PHA00666 1124936011219 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1124936011220 Integrase; Region: Integrase_1; pfam12835 1124936011221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1124936011222 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1124936011223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1124936011224 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936011225 Sel1 repeat; Region: Sel1; pfam08238 1124936011226 Sel1-like repeats; Region: SEL1; smart00671 1124936011227 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1124936011228 AMP nucleosidase; Provisional; Region: PRK08292 1124936011229 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1124936011230 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1124936011231 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1124936011232 MATE family multidrug exporter; Provisional; Region: PRK10189 1124936011233 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1124936011234 L,D-transpeptidase; Provisional; Region: PRK10190 1124936011235 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124936011236 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1124936011237 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1124936011238 putative dimer interface [polypeptide binding]; other site 1124936011239 active site pocket [active] 1124936011240 putative cataytic base [active] 1124936011241 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1124936011242 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1124936011243 homotrimer interface [polypeptide binding]; other site 1124936011244 Walker A motif; other site 1124936011245 GTP binding site [chemical binding]; other site 1124936011246 Walker B motif; other site 1124936011247 cobyric acid synthase; Provisional; Region: PRK00784 1124936011248 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124936011249 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124936011250 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1124936011251 catalytic triad [active] 1124936011252 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1124936011253 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1124936011254 Walker A/P-loop; other site 1124936011255 ATP binding site [chemical binding]; other site 1124936011256 Q-loop/lid; other site 1124936011257 ABC transporter signature motif; other site 1124936011258 Walker B; other site 1124936011259 D-loop; other site 1124936011260 H-loop/switch region; other site 1124936011261 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1124936011262 cobalt transport protein CbiN; Provisional; Region: PRK02898 1124936011263 cobalt transport protein CbiM; Validated; Region: PRK08319 1124936011264 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1124936011265 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1124936011266 active site 1124936011267 SAM binding site [chemical binding]; other site 1124936011268 homodimer interface [polypeptide binding]; other site 1124936011269 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1124936011270 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1124936011271 active site 1124936011272 C-terminal domain interface [polypeptide binding]; other site 1124936011273 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1124936011274 active site 1124936011275 N-terminal domain interface [polypeptide binding]; other site 1124936011276 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1124936011277 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1124936011278 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1124936011279 active site 1124936011280 SAM binding site [chemical binding]; other site 1124936011281 homodimer interface [polypeptide binding]; other site 1124936011282 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1124936011283 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1124936011284 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1124936011285 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1124936011286 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1124936011287 active site 1124936011288 SAM binding site [chemical binding]; other site 1124936011289 homodimer interface [polypeptide binding]; other site 1124936011290 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1124936011291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936011292 S-adenosylmethionine binding site [chemical binding]; other site 1124936011293 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1124936011294 active site 1124936011295 putative homodimer interface [polypeptide binding]; other site 1124936011296 SAM binding site [chemical binding]; other site 1124936011297 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1124936011298 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1124936011299 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1124936011300 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1124936011301 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1124936011302 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1124936011303 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1124936011304 catalytic triad [active] 1124936011305 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1124936011306 Sensory domain found in PocR; Region: PocR; pfam10114 1124936011307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936011308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124936011309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936011310 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1124936011311 amphipathic channel; other site 1124936011312 Asn-Pro-Ala signature motifs; other site 1124936011313 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1124936011314 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1124936011315 Hexamer interface [polypeptide binding]; other site 1124936011316 Putative hexagonal pore residue; other site 1124936011317 propanediol utilization protein PduB; Provisional; Region: PRK15415 1124936011318 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1124936011319 putative hexamer interface [polypeptide binding]; other site 1124936011320 putative hexagonal pore; other site 1124936011321 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1124936011322 putative hexamer interface [polypeptide binding]; other site 1124936011323 putative hexagonal pore; other site 1124936011324 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1124936011325 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1124936011326 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1124936011327 alpha-beta subunit interface [polypeptide binding]; other site 1124936011328 alpha-gamma subunit interface [polypeptide binding]; other site 1124936011329 active site 1124936011330 substrate and K+ binding site; other site 1124936011331 K+ binding site [ion binding]; other site 1124936011332 cobalamin binding site [chemical binding]; other site 1124936011333 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1124936011334 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1124936011335 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1124936011336 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1124936011337 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1124936011338 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1124936011339 Hexamer interface [polypeptide binding]; other site 1124936011340 Putative hexagonal pore residue; other site 1124936011341 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1124936011342 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1124936011343 putative hexamer interface [polypeptide binding]; other site 1124936011344 putative hexagonal pore; other site 1124936011345 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1124936011346 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1124936011347 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1124936011348 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1124936011349 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1124936011350 Hexamer/Pentamer interface [polypeptide binding]; other site 1124936011351 central pore; other site 1124936011352 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1124936011353 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1124936011354 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1124936011355 putative catalytic cysteine [active] 1124936011356 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1124936011357 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1124936011358 putative active site [active] 1124936011359 metal binding site [ion binding]; metal-binding site 1124936011360 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1124936011361 SLBB domain; Region: SLBB; pfam10531 1124936011362 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1124936011363 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1124936011364 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1124936011365 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1124936011366 putative hexamer interface [polypeptide binding]; other site 1124936011367 putative hexagonal pore; other site 1124936011368 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1124936011369 putative hexamer interface [polypeptide binding]; other site 1124936011370 putative hexagonal pore; other site 1124936011371 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1124936011372 putative hexamer interface [polypeptide binding]; other site 1124936011373 putative hexagonal pore; other site 1124936011374 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 1124936011375 G3 box; other site 1124936011376 Switch II region; other site 1124936011377 GTP/Mg2+ binding site [chemical binding]; other site 1124936011378 G4 box; other site 1124936011379 G5 box; other site 1124936011380 propionate kinase; Reviewed; Region: PRK12397 1124936011381 propionate/acetate kinase; Provisional; Region: PRK12379 1124936011382 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1124936011383 hypothetical protein; Provisional; Region: PRK05423 1124936011384 Predicted membrane protein [Function unknown]; Region: COG1289 1124936011385 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124936011386 DNA gyrase inhibitor; Provisional; Region: PRK10016 1124936011387 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1124936011388 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1124936011389 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1124936011390 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1124936011391 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1124936011392 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1124936011393 4Fe-4S binding domain; Region: Fer4; cl02805 1124936011394 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1124936011395 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1124936011396 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1124936011397 putative [Fe4-S4] binding site [ion binding]; other site 1124936011398 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936011399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124936011400 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1124936011401 putative molybdopterin cofactor binding site; other site 1124936011402 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 1124936011403 SopA-like central domain; Region: SopA; pfam13981 1124936011404 SopA-like catalytic domain; Region: SopA_C; pfam13979 1124936011405 exonuclease I; Provisional; Region: sbcB; PRK11779 1124936011406 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1124936011407 active site 1124936011408 catalytic site [active] 1124936011409 substrate binding site [chemical binding]; other site 1124936011410 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1124936011411 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124936011412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936011413 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1124936011414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936011415 dimerization interface [polypeptide binding]; other site 1124936011416 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124936011417 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1124936011418 putative NAD(P) binding site [chemical binding]; other site 1124936011419 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1124936011420 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1124936011421 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1124936011422 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1124936011423 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1124936011424 NAD binding site [chemical binding]; other site 1124936011425 dimerization interface [polypeptide binding]; other site 1124936011426 product binding site; other site 1124936011427 substrate binding site [chemical binding]; other site 1124936011428 zinc binding site [ion binding]; other site 1124936011429 catalytic residues [active] 1124936011430 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1124936011431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936011432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936011433 homodimer interface [polypeptide binding]; other site 1124936011434 catalytic residue [active] 1124936011435 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1124936011436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936011437 active site 1124936011438 motif I; other site 1124936011439 motif II; other site 1124936011440 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1124936011441 putative active site pocket [active] 1124936011442 4-fold oligomerization interface [polypeptide binding]; other site 1124936011443 metal binding residues [ion binding]; metal-binding site 1124936011444 3-fold/trimer interface [polypeptide binding]; other site 1124936011445 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1124936011446 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1124936011447 putative active site [active] 1124936011448 oxyanion strand; other site 1124936011449 catalytic triad [active] 1124936011450 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1124936011451 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1124936011452 catalytic residues [active] 1124936011453 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1124936011454 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1124936011455 substrate binding site [chemical binding]; other site 1124936011456 glutamase interaction surface [polypeptide binding]; other site 1124936011457 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1124936011458 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1124936011459 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1124936011460 metal binding site [ion binding]; metal-binding site 1124936011461 chain length determinant protein WzzB; Provisional; Region: PRK15471 1124936011462 Chain length determinant protein; Region: Wzz; pfam02706 1124936011463 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1124936011464 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1124936011465 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1124936011466 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1124936011467 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1124936011468 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124936011469 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1124936011470 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1124936011471 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1124936011472 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1124936011473 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1124936011474 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1124936011475 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1124936011476 active site 1124936011477 substrate binding site [chemical binding]; other site 1124936011478 metal binding site [ion binding]; metal-binding site 1124936011479 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1124936011480 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1124936011481 Substrate binding site; other site 1124936011482 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1124936011483 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124936011484 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1124936011485 active site 1124936011486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124936011487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124936011488 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1124936011489 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1124936011490 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1124936011491 active site 1124936011492 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1124936011493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124936011494 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1124936011495 NAD(P) binding site [chemical binding]; other site 1124936011496 active site 1124936011497 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1124936011498 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124936011499 inhibitor-cofactor binding pocket; inhibition site 1124936011500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936011501 catalytic residue [active] 1124936011502 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1124936011503 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1124936011504 NAD binding site [chemical binding]; other site 1124936011505 homotetramer interface [polypeptide binding]; other site 1124936011506 homodimer interface [polypeptide binding]; other site 1124936011507 substrate binding site [chemical binding]; other site 1124936011508 active site 1124936011509 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1124936011510 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1124936011511 substrate binding site; other site 1124936011512 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1124936011513 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124936011514 catalytic loop [active] 1124936011515 iron binding site [ion binding]; other site 1124936011516 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1124936011517 FAD binding pocket [chemical binding]; other site 1124936011518 FAD binding motif [chemical binding]; other site 1124936011519 phosphate binding motif [ion binding]; other site 1124936011520 beta-alpha-beta structure motif; other site 1124936011521 NAD binding pocket [chemical binding]; other site 1124936011522 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1124936011523 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1124936011524 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1124936011525 substrate binding site; other site 1124936011526 tetramer interface; other site 1124936011527 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1124936011528 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1124936011529 NADP binding site [chemical binding]; other site 1124936011530 active site 1124936011531 putative substrate binding site [chemical binding]; other site 1124936011532 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1124936011533 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1124936011534 NAD binding site [chemical binding]; other site 1124936011535 substrate binding site [chemical binding]; other site 1124936011536 homodimer interface [polypeptide binding]; other site 1124936011537 active site 1124936011538 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1124936011539 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1124936011540 active site 1124936011541 tetramer interface; other site 1124936011542 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1124936011543 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1124936011544 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1124936011545 putative ADP-binding pocket [chemical binding]; other site 1124936011546 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1124936011547 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1124936011548 colanic acid exporter; Provisional; Region: PRK10459 1124936011549 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1124936011550 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1124936011551 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1124936011552 phosphomannomutase CpsG; Provisional; Region: PRK15414 1124936011553 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1124936011554 active site 1124936011555 substrate binding site [chemical binding]; other site 1124936011556 metal binding site [ion binding]; metal-binding site 1124936011557 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1124936011558 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1124936011559 Substrate binding site; other site 1124936011560 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1124936011561 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1124936011562 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1124936011563 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1124936011564 active site 1124936011565 GDP-Mannose binding site [chemical binding]; other site 1124936011566 dimer interface [polypeptide binding]; other site 1124936011567 modified nudix motif 1124936011568 metal binding site [ion binding]; metal-binding site 1124936011569 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1124936011570 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1124936011571 NADP binding site [chemical binding]; other site 1124936011572 active site 1124936011573 putative substrate binding site [chemical binding]; other site 1124936011574 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1124936011575 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1124936011576 NADP-binding site; other site 1124936011577 homotetramer interface [polypeptide binding]; other site 1124936011578 substrate binding site [chemical binding]; other site 1124936011579 homodimer interface [polypeptide binding]; other site 1124936011580 active site 1124936011581 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1124936011582 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1124936011583 putative trimer interface [polypeptide binding]; other site 1124936011584 putative active site [active] 1124936011585 putative substrate binding site [chemical binding]; other site 1124936011586 putative CoA binding site [chemical binding]; other site 1124936011587 putative glycosyl transferase; Provisional; Region: PRK10063 1124936011588 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1124936011589 metal-binding site 1124936011590 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1124936011591 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1124936011592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124936011593 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124936011594 putative acyl transferase; Provisional; Region: PRK10191 1124936011595 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1124936011596 trimer interface [polypeptide binding]; other site 1124936011597 active site 1124936011598 substrate binding site [chemical binding]; other site 1124936011599 CoA binding site [chemical binding]; other site 1124936011600 putative glycosyl transferase; Provisional; Region: PRK10018 1124936011601 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1124936011602 active site 1124936011603 tyrosine kinase; Provisional; Region: PRK11519 1124936011604 Chain length determinant protein; Region: Wzz; pfam02706 1124936011605 Chain length determinant protein; Region: Wzz; cl15801 1124936011606 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1124936011607 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124936011608 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1124936011609 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1124936011610 active site 1124936011611 polysaccharide export protein Wza; Provisional; Region: PRK15078 1124936011612 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1124936011613 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1124936011614 FOG: CBS domain [General function prediction only]; Region: COG0517 1124936011615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124936011616 Transporter associated domain; Region: CorC_HlyC; smart01091 1124936011617 putative assembly protein; Provisional; Region: PRK10833 1124936011618 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1124936011619 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1124936011620 trimer interface [polypeptide binding]; other site 1124936011621 active site 1124936011622 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1124936011623 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1124936011624 ATP-binding site [chemical binding]; other site 1124936011625 Sugar specificity; other site 1124936011626 Pyrimidine base specificity; other site 1124936011627 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1124936011628 PAS domain S-box; Region: sensory_box; TIGR00229 1124936011629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936011630 putative active site [active] 1124936011631 heme pocket [chemical binding]; other site 1124936011632 PAS domain S-box; Region: sensory_box; TIGR00229 1124936011633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124936011634 putative active site [active] 1124936011635 heme pocket [chemical binding]; other site 1124936011636 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124936011637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936011638 metal binding site [ion binding]; metal-binding site 1124936011639 active site 1124936011640 I-site; other site 1124936011641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936011642 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1124936011643 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1124936011644 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124936011645 minor groove reading motif; other site 1124936011646 helix-hairpin-helix signature motif; other site 1124936011647 substrate binding pocket [chemical binding]; other site 1124936011648 active site 1124936011649 putative chaperone; Provisional; Region: PRK11678 1124936011650 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1124936011651 nucleotide binding site [chemical binding]; other site 1124936011652 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1124936011653 SBD interface [polypeptide binding]; other site 1124936011654 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1124936011655 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936011656 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936011657 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1124936011658 Protein export membrane protein; Region: SecD_SecF; cl14618 1124936011659 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1124936011660 putative transporter; Provisional; Region: PRK10504 1124936011661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936011662 putative substrate translocation pore; other site 1124936011663 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1124936011664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936011665 dimerization interface [polypeptide binding]; other site 1124936011666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936011667 dimer interface [polypeptide binding]; other site 1124936011668 phosphorylation site [posttranslational modification] 1124936011669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936011670 ATP binding site [chemical binding]; other site 1124936011671 Mg2+ binding site [ion binding]; other site 1124936011672 G-X-G motif; other site 1124936011673 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1124936011674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936011675 active site 1124936011676 phosphorylation site [posttranslational modification] 1124936011677 intermolecular recognition site; other site 1124936011678 dimerization interface [polypeptide binding]; other site 1124936011679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936011680 DNA binding site [nucleotide binding] 1124936011681 PcfJ-like protein; Region: PcfJ; pfam14284 1124936011682 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1124936011683 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 1124936011684 putative protease; Provisional; Region: PRK15452 1124936011685 Peptidase family U32; Region: Peptidase_U32; pfam01136 1124936011686 type III secretion system protein; Provisional; Region: PRK15383 1124936011687 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1124936011688 lipid kinase; Reviewed; Region: PRK13054 1124936011689 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1124936011690 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1124936011691 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1124936011692 putative active site; other site 1124936011693 catalytic residue [active] 1124936011694 nucleoside transporter; Region: 2A0110; TIGR00889 1124936011695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936011696 putative substrate translocation pore; other site 1124936011697 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1124936011698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124936011699 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1124936011700 substrate binding site [chemical binding]; other site 1124936011701 ATP binding site [chemical binding]; other site 1124936011702 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1124936011703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936011704 DNA-binding site [nucleotide binding]; DNA binding site 1124936011705 UTRA domain; Region: UTRA; pfam07702 1124936011706 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1124936011707 dimer interface [polypeptide binding]; other site 1124936011708 substrate binding site [chemical binding]; other site 1124936011709 ATP binding site [chemical binding]; other site 1124936011710 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1124936011711 substrate binding site [chemical binding]; other site 1124936011712 multimerization interface [polypeptide binding]; other site 1124936011713 ATP binding site [chemical binding]; other site 1124936011714 Predicted integral membrane protein [Function unknown]; Region: COG5455 1124936011715 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1124936011716 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1124936011717 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1124936011718 PapC N-terminal domain; Region: PapC_N; pfam13954 1124936011719 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124936011720 PapC C-terminal domain; Region: PapC_C; pfam13953 1124936011721 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 1124936011722 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124936011723 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124936011724 fimbrial chaperone protein; Provisional; Region: PRK15220 1124936011725 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1124936011726 antiporter inner membrane protein; Provisional; Region: PRK11670 1124936011727 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1124936011728 Walker A motif; other site 1124936011729 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1124936011730 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1124936011731 active site 1124936011732 HIGH motif; other site 1124936011733 KMSKS motif; other site 1124936011734 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1124936011735 tRNA binding surface [nucleotide binding]; other site 1124936011736 anticodon binding site; other site 1124936011737 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1124936011738 dimer interface [polypeptide binding]; other site 1124936011739 putative tRNA-binding site [nucleotide binding]; other site 1124936011740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1124936011741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1124936011742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1124936011743 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1124936011744 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1124936011745 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1124936011746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936011747 active site 1124936011748 phosphorylation site [posttranslational modification] 1124936011749 intermolecular recognition site; other site 1124936011750 dimerization interface [polypeptide binding]; other site 1124936011751 LytTr DNA-binding domain; Region: LytTR; pfam04397 1124936011752 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1124936011753 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1124936011754 GAF domain; Region: GAF; pfam01590 1124936011755 Histidine kinase; Region: His_kinase; pfam06580 1124936011756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936011757 ATP binding site [chemical binding]; other site 1124936011758 Mg2+ binding site [ion binding]; other site 1124936011759 G-X-G motif; other site 1124936011760 transcriptional regulator MirA; Provisional; Region: PRK15043 1124936011761 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1124936011762 DNA binding residues [nucleotide binding] 1124936011763 hypothetical protein; Provisional; Region: PRK13681 1124936011764 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1124936011765 putative PBP binding loops; other site 1124936011766 ABC-ATPase subunit interface; other site 1124936011767 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1124936011768 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1124936011769 Walker A/P-loop; other site 1124936011770 ATP binding site [chemical binding]; other site 1124936011771 Q-loop/lid; other site 1124936011772 ABC transporter signature motif; other site 1124936011773 Walker B; other site 1124936011774 D-loop; other site 1124936011775 H-loop/switch region; other site 1124936011776 CBS domain; Region: CBS; pfam00571 1124936011777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936011778 dimer interface [polypeptide binding]; other site 1124936011779 conserved gate region; other site 1124936011780 ABC-ATPase subunit interface; other site 1124936011781 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1124936011782 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1124936011783 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1124936011784 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1124936011785 D-lactate dehydrogenase; Provisional; Region: PRK11183 1124936011786 FAD binding domain; Region: FAD_binding_4; pfam01565 1124936011787 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1124936011788 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1124936011789 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1124936011790 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1124936011791 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124936011792 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1124936011793 oxidoreductase; Provisional; Region: PRK12743 1124936011794 classical (c) SDRs; Region: SDR_c; cd05233 1124936011795 NAD(P) binding site [chemical binding]; other site 1124936011796 active site 1124936011797 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1124936011798 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1124936011799 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1124936011800 FMN binding site [chemical binding]; other site 1124936011801 active site 1124936011802 catalytic residues [active] 1124936011803 substrate binding site [chemical binding]; other site 1124936011804 salicylate hydroxylase; Provisional; Region: PRK08163 1124936011805 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124936011806 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1124936011807 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1124936011808 C-terminal domain interface [polypeptide binding]; other site 1124936011809 GSH binding site (G-site) [chemical binding]; other site 1124936011810 putative dimer interface [polypeptide binding]; other site 1124936011811 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1124936011812 dimer interface [polypeptide binding]; other site 1124936011813 N-terminal domain interface [polypeptide binding]; other site 1124936011814 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1124936011815 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1124936011816 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1124936011817 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1124936011818 Cupin domain; Region: Cupin_2; pfam07883 1124936011819 Cupin domain; Region: Cupin_2; pfam07883 1124936011820 benzoate transport; Region: 2A0115; TIGR00895 1124936011821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936011822 putative substrate translocation pore; other site 1124936011823 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1124936011824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936011825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124936011826 dimerization interface [polypeptide binding]; other site 1124936011827 hypothetical protein; Provisional; Region: PRK01821 1124936011828 hypothetical protein; Provisional; Region: PRK10711 1124936011829 cytidine deaminase; Provisional; Region: PRK09027 1124936011830 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1124936011831 active site 1124936011832 catalytic motif [active] 1124936011833 Zn binding site [ion binding]; other site 1124936011834 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1124936011835 active site 1124936011836 catalytic motif [active] 1124936011837 Zn binding site [ion binding]; other site 1124936011838 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1124936011839 putative active site [active] 1124936011840 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1124936011841 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1124936011842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124936011843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936011844 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1124936011845 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1124936011846 homodimer interface [polypeptide binding]; other site 1124936011847 active site 1124936011848 FMN binding site [chemical binding]; other site 1124936011849 substrate binding site [chemical binding]; other site 1124936011850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124936011851 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1124936011852 TM-ABC transporter signature motif; other site 1124936011853 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1124936011854 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1124936011855 Walker A/P-loop; other site 1124936011856 ATP binding site [chemical binding]; other site 1124936011857 Q-loop/lid; other site 1124936011858 ABC transporter signature motif; other site 1124936011859 Walker B; other site 1124936011860 D-loop; other site 1124936011861 H-loop/switch region; other site 1124936011862 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1124936011863 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1124936011864 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1124936011865 ligand binding site [chemical binding]; other site 1124936011866 calcium binding site [ion binding]; other site 1124936011867 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1124936011868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936011869 DNA binding site [nucleotide binding] 1124936011870 domain linker motif; other site 1124936011871 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1124936011872 dimerization interface (closed form) [polypeptide binding]; other site 1124936011873 ligand binding site [chemical binding]; other site 1124936011874 Predicted membrane protein [Function unknown]; Region: COG2311 1124936011875 hypothetical protein; Provisional; Region: PRK10835 1124936011876 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1124936011877 GTP cyclohydrolase I; Provisional; Region: PLN03044 1124936011878 active site 1124936011879 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1124936011880 S-formylglutathione hydrolase; Region: PLN02442 1124936011881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936011882 non-specific DNA binding site [nucleotide binding]; other site 1124936011883 salt bridge; other site 1124936011884 sequence-specific DNA binding site [nucleotide binding]; other site 1124936011885 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1124936011886 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124936011887 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124936011888 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1124936011889 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124936011890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936011891 motif II; other site 1124936011892 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1124936011893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936011894 putative substrate translocation pore; other site 1124936011895 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1124936011896 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936011897 N-terminal plug; other site 1124936011898 ligand-binding site [chemical binding]; other site 1124936011899 lysine transporter; Provisional; Region: PRK10836 1124936011900 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1124936011901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936011902 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1124936011903 putative dimerization interface [polypeptide binding]; other site 1124936011904 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1124936011905 endonuclease IV; Provisional; Region: PRK01060 1124936011906 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1124936011907 AP (apurinic/apyrimidinic) site pocket; other site 1124936011908 DNA interaction; other site 1124936011909 Metal-binding active site; metal-binding site 1124936011910 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1124936011911 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1124936011912 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1124936011913 active site 1124936011914 P-loop; other site 1124936011915 phosphorylation site [posttranslational modification] 1124936011916 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1124936011917 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1124936011918 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1124936011919 putative substrate binding site [chemical binding]; other site 1124936011920 putative ATP binding site [chemical binding]; other site 1124936011921 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1124936011922 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936011923 active site 1124936011924 phosphorylation site [posttranslational modification] 1124936011925 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124936011926 dimerization domain swap beta strand [polypeptide binding]; other site 1124936011927 regulatory protein interface [polypeptide binding]; other site 1124936011928 active site 1124936011929 regulatory phosphorylation site [posttranslational modification]; other site 1124936011930 sugar efflux transporter B; Provisional; Region: PRK15011 1124936011931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936011932 putative substrate translocation pore; other site 1124936011933 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1124936011934 Flagellin N-methylase; Region: FliB; cl00497 1124936011935 elongation factor P; Provisional; Region: PRK04542 1124936011936 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1124936011937 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1124936011938 RNA binding site [nucleotide binding]; other site 1124936011939 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1124936011940 RNA binding site [nucleotide binding]; other site 1124936011941 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1124936011942 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1124936011943 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1124936011944 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124936011945 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1124936011946 active site 1124936011947 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1124936011948 NlpC/P60 family; Region: NLPC_P60; pfam00877 1124936011949 phage resistance protein; Provisional; Region: PRK10551 1124936011950 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124936011951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936011952 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1124936011953 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1124936011954 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1124936011955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936011956 dimer interface [polypeptide binding]; other site 1124936011957 conserved gate region; other site 1124936011958 putative PBP binding loops; other site 1124936011959 ABC-ATPase subunit interface; other site 1124936011960 microcin C ABC transporter permease; Provisional; Region: PRK15021 1124936011961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936011962 dimer interface [polypeptide binding]; other site 1124936011963 conserved gate region; other site 1124936011964 ABC-ATPase subunit interface; other site 1124936011965 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1124936011966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936011967 Walker A/P-loop; other site 1124936011968 ATP binding site [chemical binding]; other site 1124936011969 Q-loop/lid; other site 1124936011970 ABC transporter signature motif; other site 1124936011971 Walker B; other site 1124936011972 D-loop; other site 1124936011973 H-loop/switch region; other site 1124936011974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1124936011975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124936011976 Walker A/P-loop; other site 1124936011977 ATP binding site [chemical binding]; other site 1124936011978 Q-loop/lid; other site 1124936011979 ABC transporter signature motif; other site 1124936011980 Walker B; other site 1124936011981 D-loop; other site 1124936011982 H-loop/switch region; other site 1124936011983 hypothetical protein; Provisional; Region: PRK11835 1124936011984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936011985 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1124936011986 putative substrate translocation pore; other site 1124936011987 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1124936011988 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936011989 RNA binding surface [nucleotide binding]; other site 1124936011990 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1124936011991 active site 1124936011992 uracil binding [chemical binding]; other site 1124936011993 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1124936011994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124936011995 ATP binding site [chemical binding]; other site 1124936011996 putative Mg++ binding site [ion binding]; other site 1124936011997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936011998 nucleotide binding region [chemical binding]; other site 1124936011999 ATP-binding site [chemical binding]; other site 1124936012000 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1124936012001 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1124936012002 5S rRNA interface [nucleotide binding]; other site 1124936012003 CTC domain interface [polypeptide binding]; other site 1124936012004 L16 interface [polypeptide binding]; other site 1124936012005 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1124936012006 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1124936012007 hypothetical protein; Provisional; Region: PRK13689 1124936012008 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1124936012009 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1124936012010 Sulfatase; Region: Sulfatase; cl17466 1124936012011 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1124936012012 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124936012013 Catalytic site [active] 1124936012014 DinI-like family; Region: DinI; cl11630 1124936012015 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1124936012016 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1124936012017 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1124936012018 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 1124936012019 Phage head maturation protease [General function prediction only]; Region: COG3740 1124936012020 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1124936012021 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1124936012022 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1124936012023 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1124936012024 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1124936012025 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1124936012026 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 1124936012027 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1124936012028 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1124936012029 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1124936012030 Leucine-rich repeats; other site 1124936012031 Substrate binding site [chemical binding]; other site 1124936012032 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1124936012033 DinI-like family; Region: DinI; cl11630 1124936012034 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1124936012035 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1124936012036 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1124936012037 transcriptional regulator NarP; Provisional; Region: PRK10403 1124936012038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936012039 active site 1124936012040 phosphorylation site [posttranslational modification] 1124936012041 intermolecular recognition site; other site 1124936012042 dimerization interface [polypeptide binding]; other site 1124936012043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936012044 DNA binding residues [nucleotide binding] 1124936012045 dimerization interface [polypeptide binding]; other site 1124936012046 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1124936012047 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1124936012048 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1124936012049 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1124936012050 catalytic residues [active] 1124936012051 central insert; other site 1124936012052 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1124936012053 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1124936012054 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1124936012055 heme exporter protein CcmC; Region: ccmC; TIGR01191 1124936012056 heme exporter protein CcmB; Region: ccmB; TIGR01190 1124936012057 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1124936012058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936012059 Walker A/P-loop; other site 1124936012060 ATP binding site [chemical binding]; other site 1124936012061 Q-loop/lid; other site 1124936012062 ABC transporter signature motif; other site 1124936012063 Walker B; other site 1124936012064 D-loop; other site 1124936012065 H-loop/switch region; other site 1124936012066 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1124936012067 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1124936012068 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1124936012069 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1124936012070 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1124936012071 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936012072 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1124936012073 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1124936012074 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1124936012075 [4Fe-4S] binding site [ion binding]; other site 1124936012076 molybdopterin cofactor binding site; other site 1124936012077 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1124936012078 molybdopterin cofactor binding site; other site 1124936012079 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1124936012080 ferredoxin-type protein; Provisional; Region: PRK10194 1124936012081 4Fe-4S binding domain; Region: Fer4; cl02805 1124936012082 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1124936012083 secondary substrate binding site; other site 1124936012084 primary substrate binding site; other site 1124936012085 inhibition loop; other site 1124936012086 dimerization interface [polypeptide binding]; other site 1124936012087 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1124936012088 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1124936012089 Walker A/P-loop; other site 1124936012090 ATP binding site [chemical binding]; other site 1124936012091 Q-loop/lid; other site 1124936012092 ABC transporter signature motif; other site 1124936012093 Walker B; other site 1124936012094 D-loop; other site 1124936012095 H-loop/switch region; other site 1124936012096 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1124936012097 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1124936012098 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1124936012099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936012100 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1124936012101 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124936012102 DNA binding site [nucleotide binding] 1124936012103 active site 1124936012104 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1124936012105 ApbE family; Region: ApbE; pfam02424 1124936012106 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1124936012107 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1124936012108 trimer interface [polypeptide binding]; other site 1124936012109 eyelet of channel; other site 1124936012110 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1124936012111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936012112 ATP binding site [chemical binding]; other site 1124936012113 G-X-G motif; other site 1124936012114 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124936012115 putative binding surface; other site 1124936012116 active site 1124936012117 transcriptional regulator RcsB; Provisional; Region: PRK10840 1124936012118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936012119 active site 1124936012120 phosphorylation site [posttranslational modification] 1124936012121 intermolecular recognition site; other site 1124936012122 dimerization interface [polypeptide binding]; other site 1124936012123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124936012124 DNA binding residues [nucleotide binding] 1124936012125 dimerization interface [polypeptide binding]; other site 1124936012126 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1124936012127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936012128 dimer interface [polypeptide binding]; other site 1124936012129 phosphorylation site [posttranslational modification] 1124936012130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936012131 ATP binding site [chemical binding]; other site 1124936012132 Mg2+ binding site [ion binding]; other site 1124936012133 G-X-G motif; other site 1124936012134 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1124936012135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936012136 active site 1124936012137 phosphorylation site [posttranslational modification] 1124936012138 intermolecular recognition site; other site 1124936012139 dimerization interface [polypeptide binding]; other site 1124936012140 DNA gyrase subunit A; Validated; Region: PRK05560 1124936012141 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1124936012142 CAP-like domain; other site 1124936012143 active site 1124936012144 primary dimer interface [polypeptide binding]; other site 1124936012145 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936012146 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936012147 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936012148 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936012149 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936012150 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124936012151 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1124936012152 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1124936012153 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1124936012154 active site pocket [active] 1124936012155 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1124936012156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012157 putative substrate translocation pore; other site 1124936012158 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124936012159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936012160 DNA-binding site [nucleotide binding]; DNA binding site 1124936012161 FCD domain; Region: FCD; pfam07729 1124936012162 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1124936012163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936012164 S-adenosylmethionine binding site [chemical binding]; other site 1124936012165 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1124936012166 ATP cone domain; Region: ATP-cone; pfam03477 1124936012167 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1124936012168 active site 1124936012169 dimer interface [polypeptide binding]; other site 1124936012170 catalytic residues [active] 1124936012171 effector binding site; other site 1124936012172 R2 peptide binding site; other site 1124936012173 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1124936012174 dimer interface [polypeptide binding]; other site 1124936012175 putative radical transfer pathway; other site 1124936012176 diiron center [ion binding]; other site 1124936012177 tyrosyl radical; other site 1124936012178 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1124936012179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124936012180 catalytic loop [active] 1124936012181 iron binding site [ion binding]; other site 1124936012182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936012183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012184 putative substrate translocation pore; other site 1124936012185 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1124936012186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936012187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936012188 dimerization interface [polypeptide binding]; other site 1124936012189 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1124936012190 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1124936012191 active site 1124936012192 catalytic site [active] 1124936012193 metal binding site [ion binding]; metal-binding site 1124936012194 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1124936012195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012196 putative substrate translocation pore; other site 1124936012197 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1124936012198 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124936012199 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124936012200 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1124936012201 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1124936012202 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1124936012203 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936012204 Cysteine-rich domain; Region: CCG; pfam02754 1124936012205 Cysteine-rich domain; Region: CCG; pfam02754 1124936012206 deubiquitinase SseL; Provisional; Region: PRK14848 1124936012207 hypothetical protein; Provisional; Region: PRK03673 1124936012208 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1124936012209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012210 D-galactonate transporter; Region: 2A0114; TIGR00893 1124936012211 putative substrate translocation pore; other site 1124936012212 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1124936012213 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1124936012214 putative active site pocket [active] 1124936012215 putative metal binding site [ion binding]; other site 1124936012216 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124936012217 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124936012218 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124936012219 hypothetical protein; Provisional; Region: PRK03673 1124936012220 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1124936012221 putative MPT binding site; other site 1124936012222 Competence-damaged protein; Region: CinA; cl00666 1124936012223 YfaZ precursor; Region: YfaZ; pfam07437 1124936012224 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1124936012225 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1124936012226 catalytic core [active] 1124936012227 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1124936012228 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124936012229 inhibitor-cofactor binding pocket; inhibition site 1124936012230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936012231 catalytic residue [active] 1124936012232 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1124936012233 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1124936012234 Ligand binding site; other site 1124936012235 Putative Catalytic site; other site 1124936012236 DXD motif; other site 1124936012237 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1124936012238 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1124936012239 active site 1124936012240 substrate binding site [chemical binding]; other site 1124936012241 cosubstrate binding site; other site 1124936012242 catalytic site [active] 1124936012243 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1124936012244 active site 1124936012245 hexamer interface [polypeptide binding]; other site 1124936012246 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1124936012247 NAD binding site [chemical binding]; other site 1124936012248 substrate binding site [chemical binding]; other site 1124936012249 active site 1124936012250 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1124936012251 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1124936012252 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1124936012253 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1124936012254 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1124936012255 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1124936012256 signal transduction protein PmrD; Provisional; Region: PRK15450 1124936012257 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1124936012258 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1124936012259 acyl-activating enzyme (AAE) consensus motif; other site 1124936012260 putative AMP binding site [chemical binding]; other site 1124936012261 putative active site [active] 1124936012262 putative CoA binding site [chemical binding]; other site 1124936012263 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 1124936012264 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1124936012265 active site 1124936012266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124936012267 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1124936012268 substrate binding site [chemical binding]; other site 1124936012269 oxyanion hole (OAH) forming residues; other site 1124936012270 trimer interface [polypeptide binding]; other site 1124936012271 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1124936012272 potential frameshift: common BLAST hit: gi|386592118|ref|YP_006088518.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate 1124936012273 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1124936012274 isochorismate synthases; Region: isochor_syn; TIGR00543 1124936012275 hypothetical protein; Provisional; Region: PRK10404 1124936012276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936012277 Coenzyme A binding pocket [chemical binding]; other site 1124936012278 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1124936012279 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124936012280 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124936012281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936012282 active site 1124936012283 phosphorylation site [posttranslational modification] 1124936012284 intermolecular recognition site; other site 1124936012285 dimerization interface [polypeptide binding]; other site 1124936012286 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1124936012287 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124936012288 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1124936012289 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124936012290 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1124936012291 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1124936012292 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124936012293 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1124936012294 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1124936012295 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1124936012296 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1124936012297 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936012298 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936012299 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1124936012300 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1124936012301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124936012302 catalytic loop [active] 1124936012303 iron binding site [ion binding]; other site 1124936012304 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1124936012305 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1124936012306 [4Fe-4S] binding site [ion binding]; other site 1124936012307 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1124936012308 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1124936012309 SLBB domain; Region: SLBB; pfam10531 1124936012310 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1124936012311 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1124936012312 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1124936012313 putative dimer interface [polypeptide binding]; other site 1124936012314 [2Fe-2S] cluster binding site [ion binding]; other site 1124936012315 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1124936012316 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1124936012317 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1124936012318 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1124936012319 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1124936012320 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1124936012321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936012322 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1124936012323 putative dimerization interface [polypeptide binding]; other site 1124936012324 aminotransferase AlaT; Validated; Region: PRK09265 1124936012325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936012326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936012327 homodimer interface [polypeptide binding]; other site 1124936012328 catalytic residue [active] 1124936012329 5'-nucleotidase; Provisional; Region: PRK03826 1124936012330 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1124936012331 transmembrane helices; other site 1124936012332 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1124936012333 TrkA-C domain; Region: TrkA_C; pfam02080 1124936012334 TrkA-C domain; Region: TrkA_C; pfam02080 1124936012335 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1124936012336 putative phosphatase; Provisional; Region: PRK11587 1124936012337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936012338 motif II; other site 1124936012339 hypothetical protein; Validated; Region: PRK05445 1124936012340 hypothetical protein; Provisional; Region: PRK01816 1124936012341 propionate/acetate kinase; Provisional; Region: PRK12379 1124936012342 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1124936012343 phosphate acetyltransferase; Reviewed; Region: PRK05632 1124936012344 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124936012345 DRTGG domain; Region: DRTGG; pfam07085 1124936012346 phosphate acetyltransferase; Region: pta; TIGR00651 1124936012347 hypothetical protein; Provisional; Region: PRK11588 1124936012348 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1124936012349 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1124936012350 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1124936012351 PYR/PP interface [polypeptide binding]; other site 1124936012352 dimer interface [polypeptide binding]; other site 1124936012353 TPP binding site [chemical binding]; other site 1124936012354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124936012355 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1124936012356 TPP-binding site [chemical binding]; other site 1124936012357 dimer interface [polypeptide binding]; other site 1124936012358 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1124936012359 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1124936012360 active site 1124936012361 P-loop; other site 1124936012362 phosphorylation site [posttranslational modification] 1124936012363 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124936012364 active site 1124936012365 phosphorylation site [posttranslational modification] 1124936012366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124936012367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124936012368 DNA binding site [nucleotide binding] 1124936012369 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1124936012370 putative dimerization interface [polypeptide binding]; other site 1124936012371 putative ligand binding site [chemical binding]; other site 1124936012372 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1124936012373 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1124936012374 nudix motif; other site 1124936012375 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1124936012376 active site 1124936012377 metal binding site [ion binding]; metal-binding site 1124936012378 homotetramer interface [polypeptide binding]; other site 1124936012379 glutathione S-transferase; Provisional; Region: PRK15113 1124936012380 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1124936012381 C-terminal domain interface [polypeptide binding]; other site 1124936012382 GSH binding site (G-site) [chemical binding]; other site 1124936012383 dimer interface [polypeptide binding]; other site 1124936012384 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1124936012385 N-terminal domain interface [polypeptide binding]; other site 1124936012386 putative dimer interface [polypeptide binding]; other site 1124936012387 putative substrate binding pocket (H-site) [chemical binding]; other site 1124936012388 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1124936012389 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1124936012390 C-terminal domain interface [polypeptide binding]; other site 1124936012391 GSH binding site (G-site) [chemical binding]; other site 1124936012392 dimer interface [polypeptide binding]; other site 1124936012393 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1124936012394 N-terminal domain interface [polypeptide binding]; other site 1124936012395 putative dimer interface [polypeptide binding]; other site 1124936012396 active site 1124936012397 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1124936012398 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1124936012399 putative NAD(P) binding site [chemical binding]; other site 1124936012400 putative active site [active] 1124936012401 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1124936012402 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124936012403 Walker A/P-loop; other site 1124936012404 ATP binding site [chemical binding]; other site 1124936012405 Q-loop/lid; other site 1124936012406 ABC transporter signature motif; other site 1124936012407 Walker B; other site 1124936012408 D-loop; other site 1124936012409 H-loop/switch region; other site 1124936012410 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936012411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936012412 dimer interface [polypeptide binding]; other site 1124936012413 conserved gate region; other site 1124936012414 putative PBP binding loops; other site 1124936012415 ABC-ATPase subunit interface; other site 1124936012416 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124936012417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936012418 dimer interface [polypeptide binding]; other site 1124936012419 conserved gate region; other site 1124936012420 putative PBP binding loops; other site 1124936012421 ABC-ATPase subunit interface; other site 1124936012422 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1124936012423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936012424 substrate binding pocket [chemical binding]; other site 1124936012425 membrane-bound complex binding site; other site 1124936012426 hinge residues; other site 1124936012427 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1124936012428 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936012429 substrate binding pocket [chemical binding]; other site 1124936012430 membrane-bound complex binding site; other site 1124936012431 hinge residues; other site 1124936012432 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1124936012433 Flavoprotein; Region: Flavoprotein; pfam02441 1124936012434 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1124936012435 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1124936012436 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1124936012437 dimer interface [polypeptide binding]; other site 1124936012438 active site 1124936012439 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936012440 substrate binding site [chemical binding]; other site 1124936012441 catalytic residue [active] 1124936012442 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1124936012443 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1124936012444 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1124936012445 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124936012446 catalytic residue [active] 1124936012447 PAS fold; Region: PAS_4; pfam08448 1124936012448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1124936012449 putative active site [active] 1124936012450 heme pocket [chemical binding]; other site 1124936012451 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1124936012452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936012453 Walker A motif; other site 1124936012454 ATP binding site [chemical binding]; other site 1124936012455 Walker B motif; other site 1124936012456 arginine finger; other site 1124936012457 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124936012458 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1124936012459 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1124936012460 active site 1124936012461 tetramer interface [polypeptide binding]; other site 1124936012462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936012463 active site 1124936012464 colicin V production protein; Provisional; Region: PRK10845 1124936012465 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1124936012466 cell division protein DedD; Provisional; Region: PRK11633 1124936012467 Sporulation related domain; Region: SPOR; pfam05036 1124936012468 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1124936012469 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124936012470 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124936012471 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1124936012472 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1124936012473 hypothetical protein; Provisional; Region: PRK10847 1124936012474 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124936012475 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1124936012476 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1124936012477 dimerization interface 3.5A [polypeptide binding]; other site 1124936012478 active site 1124936012479 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1124936012480 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1124936012481 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1124936012482 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1124936012483 ligand binding site [chemical binding]; other site 1124936012484 NAD binding site [chemical binding]; other site 1124936012485 catalytic site [active] 1124936012486 homodimer interface [polypeptide binding]; other site 1124936012487 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1124936012488 putative transporter; Provisional; Region: PRK12382 1124936012489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012490 putative substrate translocation pore; other site 1124936012491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936012492 non-specific DNA binding site [nucleotide binding]; other site 1124936012493 salt bridge; other site 1124936012494 sequence-specific DNA binding site [nucleotide binding]; other site 1124936012495 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1124936012496 CAAX protease self-immunity; Region: Abi; pfam02517 1124936012497 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1124936012498 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124936012499 dimer interface [polypeptide binding]; other site 1124936012500 active site 1124936012501 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1124936012502 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1124936012503 YfcL protein; Region: YfcL; pfam08891 1124936012504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1124936012505 hypothetical protein; Provisional; Region: PRK10621 1124936012506 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124936012507 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1124936012508 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1124936012509 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1124936012510 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1124936012511 Tetramer interface [polypeptide binding]; other site 1124936012512 active site 1124936012513 FMN-binding site [chemical binding]; other site 1124936012514 HemK family putative methylases; Region: hemK_fam; TIGR00536 1124936012515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936012516 S-adenosylmethionine binding site [chemical binding]; other site 1124936012517 hypothetical protein; Provisional; Region: PRK04946 1124936012518 Smr domain; Region: Smr; pfam01713 1124936012519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124936012520 catalytic core [active] 1124936012521 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1124936012522 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124936012523 substrate binding site [chemical binding]; other site 1124936012524 oxyanion hole (OAH) forming residues; other site 1124936012525 trimer interface [polypeptide binding]; other site 1124936012526 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124936012527 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124936012528 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1124936012529 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124936012530 dimer interface [polypeptide binding]; other site 1124936012531 active site 1124936012532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1124936012533 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1124936012534 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1124936012535 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1124936012536 integrase; Provisional; Region: PRK09692 1124936012537 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1124936012538 active site 1124936012539 Int/Topo IB signature motif; other site 1124936012540 AIPR protein; Region: AIPR; pfam10592 1124936012541 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1124936012542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1124936012543 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1124936012544 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1124936012545 active site 1124936012546 metal binding site [ion binding]; metal-binding site 1124936012547 interdomain interaction site; other site 1124936012548 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1124936012549 Ash protein family; Region: Phage_ASH; pfam10554 1124936012550 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1124936012551 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1124936012552 outer membrane protease; Reviewed; Region: PRK10993 1124936012553 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124936012554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936012555 active site 1124936012556 phosphorylation site [posttranslational modification] 1124936012557 intermolecular recognition site; other site 1124936012558 dimerization interface [polypeptide binding]; other site 1124936012559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1124936012560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124936012561 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1124936012562 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1124936012563 dimerization interface [polypeptide binding]; other site 1124936012564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936012565 dimer interface [polypeptide binding]; other site 1124936012566 phosphorylation site [posttranslational modification] 1124936012567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936012568 ATP binding site [chemical binding]; other site 1124936012569 Mg2+ binding site [ion binding]; other site 1124936012570 G-X-G motif; other site 1124936012571 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124936012572 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1124936012573 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1124936012574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012576 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1124936012577 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1124936012578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1124936012579 putative acyl-acceptor binding pocket; other site 1124936012580 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1124936012581 aminotransferase; Validated; Region: PRK08175 1124936012582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936012583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936012584 homodimer interface [polypeptide binding]; other site 1124936012585 catalytic residue [active] 1124936012586 glucokinase; Provisional; Region: glk; PRK00292 1124936012587 glucokinase, proteobacterial type; Region: glk; TIGR00749 1124936012588 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1124936012589 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1124936012590 Cl- selectivity filter; other site 1124936012591 Cl- binding residues [ion binding]; other site 1124936012592 pore gating glutamate residue; other site 1124936012593 dimer interface [polypeptide binding]; other site 1124936012594 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1124936012595 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1124936012596 dimer interface [polypeptide binding]; other site 1124936012597 PYR/PP interface [polypeptide binding]; other site 1124936012598 TPP binding site [chemical binding]; other site 1124936012599 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124936012600 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1124936012601 TPP-binding site [chemical binding]; other site 1124936012602 dimer interface [polypeptide binding]; other site 1124936012603 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124936012604 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124936012605 active site 1124936012606 catalytic tetrad [active] 1124936012607 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1124936012608 manganese transport protein MntH; Reviewed; Region: PRK00701 1124936012609 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1124936012610 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1124936012611 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1124936012612 Nucleoside recognition; Region: Gate; pfam07670 1124936012613 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1124936012614 MASE1; Region: MASE1; pfam05231 1124936012615 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124936012616 diguanylate cyclase; Region: GGDEF; smart00267 1124936012617 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936012618 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1124936012619 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1124936012620 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1124936012621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1124936012622 active site 1124936012623 HIGH motif; other site 1124936012624 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1124936012625 active site 1124936012626 KMSKS motif; other site 1124936012627 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1124936012628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936012629 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1124936012630 putative dimerization interface [polypeptide binding]; other site 1124936012631 putative substrate binding pocket [chemical binding]; other site 1124936012632 XapX domain; Region: XapX; TIGR03510 1124936012633 nucleoside transporter; Region: 2A0110; TIGR00889 1124936012634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936012635 putative substrate translocation pore; other site 1124936012636 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1124936012637 hypothetical protein; Provisional; Region: PRK11528 1124936012638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936012639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936012640 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1124936012641 putative dimerization interface [polypeptide binding]; other site 1124936012642 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1124936012643 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1124936012644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1124936012645 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1124936012646 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1124936012647 nucleotide binding pocket [chemical binding]; other site 1124936012648 K-X-D-G motif; other site 1124936012649 catalytic site [active] 1124936012650 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1124936012651 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1124936012652 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1124936012653 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1124936012654 Dimer interface [polypeptide binding]; other site 1124936012655 BRCT sequence motif; other site 1124936012656 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1124936012657 cell division protein ZipA; Provisional; Region: PRK03427 1124936012658 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1124936012659 FtsZ protein binding site [polypeptide binding]; other site 1124936012660 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1124936012661 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1124936012662 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1124936012663 dimer interface [polypeptide binding]; other site 1124936012664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936012665 catalytic residue [active] 1124936012666 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124936012667 dimerization domain swap beta strand [polypeptide binding]; other site 1124936012668 regulatory protein interface [polypeptide binding]; other site 1124936012669 active site 1124936012670 regulatory phosphorylation site [posttranslational modification]; other site 1124936012671 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1124936012672 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1124936012673 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124936012674 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124936012675 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1124936012676 HPr interaction site; other site 1124936012677 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1124936012678 active site 1124936012679 phosphorylation site [posttranslational modification] 1124936012680 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1124936012681 dimer interface [polypeptide binding]; other site 1124936012682 pyridoxamine kinase; Validated; Region: PRK05756 1124936012683 pyridoxal binding site [chemical binding]; other site 1124936012684 ATP binding site [chemical binding]; other site 1124936012685 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1124936012686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936012687 DNA-binding site [nucleotide binding]; DNA binding site 1124936012688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936012689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936012690 homodimer interface [polypeptide binding]; other site 1124936012691 catalytic residue [active] 1124936012692 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1124936012693 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1124936012694 catalytic triad [active] 1124936012695 hypothetical protein; Provisional; Region: PRK10318 1124936012696 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124936012697 Sel1-like repeats; Region: SEL1; smart00671 1124936012698 cysteine synthase B; Region: cysM; TIGR01138 1124936012699 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1124936012700 dimer interface [polypeptide binding]; other site 1124936012701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936012702 catalytic residue [active] 1124936012703 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1124936012704 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1124936012705 Walker A/P-loop; other site 1124936012706 ATP binding site [chemical binding]; other site 1124936012707 Q-loop/lid; other site 1124936012708 ABC transporter signature motif; other site 1124936012709 Walker B; other site 1124936012710 D-loop; other site 1124936012711 H-loop/switch region; other site 1124936012712 TOBE-like domain; Region: TOBE_3; pfam12857 1124936012713 sulfate transport protein; Provisional; Region: cysT; CHL00187 1124936012714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936012715 dimer interface [polypeptide binding]; other site 1124936012716 conserved gate region; other site 1124936012717 putative PBP binding loops; other site 1124936012718 ABC-ATPase subunit interface; other site 1124936012719 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1124936012720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936012721 dimer interface [polypeptide binding]; other site 1124936012722 conserved gate region; other site 1124936012723 putative PBP binding loops; other site 1124936012724 ABC-ATPase subunit interface; other site 1124936012725 thiosulfate transporter subunit; Provisional; Region: PRK10852 1124936012726 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1124936012727 short chain dehydrogenase; Provisional; Region: PRK08226 1124936012728 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1124936012729 NAD binding site [chemical binding]; other site 1124936012730 homotetramer interface [polypeptide binding]; other site 1124936012731 homodimer interface [polypeptide binding]; other site 1124936012732 active site 1124936012733 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1124936012734 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1124936012735 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1124936012736 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1124936012737 putative acetyltransferase; Provisional; Region: PRK03624 1124936012738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936012739 Coenzyme A binding pocket [chemical binding]; other site 1124936012740 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1124936012741 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1124936012742 active site 1124936012743 metal binding site [ion binding]; metal-binding site 1124936012744 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1124936012745 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1124936012746 transcriptional regulator EutR; Provisional; Region: PRK10130 1124936012747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936012748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936012749 carboxysome structural protein EutK; Provisional; Region: PRK15466 1124936012750 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1124936012751 Hexamer interface [polypeptide binding]; other site 1124936012752 Hexagonal pore residue; other site 1124936012753 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1124936012754 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1124936012755 putative hexamer interface [polypeptide binding]; other site 1124936012756 putative hexagonal pore; other site 1124936012757 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1124936012758 putative hexamer interface [polypeptide binding]; other site 1124936012759 putative hexagonal pore; other site 1124936012760 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1124936012761 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1124936012762 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1124936012763 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1124936012764 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1124936012765 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1124936012766 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1124936012767 active site 1124936012768 metal binding site [ion binding]; metal-binding site 1124936012769 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1124936012770 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936012771 nucleotide binding site [chemical binding]; other site 1124936012772 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1124936012773 putative catalytic cysteine [active] 1124936012774 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1124936012775 Hexamer/Pentamer interface [polypeptide binding]; other site 1124936012776 central pore; other site 1124936012777 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1124936012778 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1124936012779 Hexamer interface [polypeptide binding]; other site 1124936012780 Putative hexagonal pore residue; other site 1124936012781 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1124936012782 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1124936012783 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1124936012784 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1124936012785 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1124936012786 G1 box; other site 1124936012787 GTP/Mg2+ binding site [chemical binding]; other site 1124936012788 G2 box; other site 1124936012789 Switch I region; other site 1124936012790 G3 box; other site 1124936012791 Switch II region; other site 1124936012792 G4 box; other site 1124936012793 G5 box; other site 1124936012794 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1124936012795 putative hexamer interface [polypeptide binding]; other site 1124936012796 putative hexagonal pore; other site 1124936012797 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1124936012798 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1124936012799 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1124936012800 putative NAD(P) binding site [chemical binding]; other site 1124936012801 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1124936012802 transaldolase-like protein; Provisional; Region: PTZ00411 1124936012803 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1124936012804 active site 1124936012805 dimer interface [polypeptide binding]; other site 1124936012806 catalytic residue [active] 1124936012807 transketolase; Reviewed; Region: PRK12753 1124936012808 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1124936012809 TPP-binding site [chemical binding]; other site 1124936012810 dimer interface [polypeptide binding]; other site 1124936012811 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1124936012812 PYR/PP interface [polypeptide binding]; other site 1124936012813 dimer interface [polypeptide binding]; other site 1124936012814 TPP binding site [chemical binding]; other site 1124936012815 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124936012816 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1124936012817 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1124936012818 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124936012819 dimer interface [polypeptide binding]; other site 1124936012820 ADP-ribose binding site [chemical binding]; other site 1124936012821 active site 1124936012822 nudix motif; other site 1124936012823 metal binding site [ion binding]; metal-binding site 1124936012824 putative periplasmic esterase; Provisional; Region: PRK03642 1124936012825 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124936012826 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1124936012827 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936012828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124936012829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936012830 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1124936012831 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1124936012832 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124936012833 dimerization interface [polypeptide binding]; other site 1124936012834 Histidine kinase; Region: HisKA_3; pfam07730 1124936012835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936012836 ATP binding site [chemical binding]; other site 1124936012837 Mg2+ binding site [ion binding]; other site 1124936012838 G-X-G motif; other site 1124936012839 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1124936012840 Protein export membrane protein; Region: SecD_SecF; cl14618 1124936012841 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1124936012842 ArsC family; Region: ArsC; pfam03960 1124936012843 putative catalytic residues [active] 1124936012844 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1124936012845 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1124936012846 metal binding site [ion binding]; metal-binding site 1124936012847 dimer interface [polypeptide binding]; other site 1124936012848 hypothetical protein; Provisional; Region: PRK13664 1124936012849 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1124936012850 Helicase; Region: Helicase_RecD; pfam05127 1124936012851 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1124936012852 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1124936012853 Predicted metalloprotease [General function prediction only]; Region: COG2321 1124936012854 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1124936012855 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1124936012856 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1124936012857 ATP binding site [chemical binding]; other site 1124936012858 active site 1124936012859 substrate binding site [chemical binding]; other site 1124936012860 lipoprotein; Provisional; Region: PRK11679 1124936012861 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1124936012862 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1124936012863 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1124936012864 dimer interface [polypeptide binding]; other site 1124936012865 active site 1124936012866 catalytic residue [active] 1124936012867 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1124936012868 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1124936012869 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1124936012870 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1124936012871 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1124936012872 catalytic triad [active] 1124936012873 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1124936012874 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1124936012875 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124936012876 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1124936012877 Peptidase family M48; Region: Peptidase_M48; cl12018 1124936012878 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1124936012879 ArsC family; Region: ArsC; pfam03960 1124936012880 catalytic residues [active] 1124936012881 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1124936012882 DNA replication initiation factor; Provisional; Region: PRK08084 1124936012883 uracil transporter; Provisional; Region: PRK10720 1124936012884 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124936012885 active site 1124936012886 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1124936012887 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1124936012888 dimerization interface [polypeptide binding]; other site 1124936012889 putative ATP binding site [chemical binding]; other site 1124936012890 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1124936012891 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1124936012892 active site 1124936012893 substrate binding site [chemical binding]; other site 1124936012894 cosubstrate binding site; other site 1124936012895 catalytic site [active] 1124936012896 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1124936012897 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1124936012898 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1124936012899 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1124936012900 putative active site [active] 1124936012901 catalytic site [active] 1124936012902 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1124936012903 domain interface [polypeptide binding]; other site 1124936012904 active site 1124936012905 catalytic site [active] 1124936012906 exopolyphosphatase; Provisional; Region: PRK10854 1124936012907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124936012908 nucleotide binding site [chemical binding]; other site 1124936012909 MASE1; Region: MASE1; pfam05231 1124936012910 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124936012911 diguanylate cyclase; Region: GGDEF; smart00267 1124936012912 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124936012913 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1124936012914 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1124936012915 Integrase core domain; Region: rve; pfam00665 1124936012916 GMP synthase; Reviewed; Region: guaA; PRK00074 1124936012917 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1124936012918 AMP/PPi binding site [chemical binding]; other site 1124936012919 candidate oxyanion hole; other site 1124936012920 catalytic triad [active] 1124936012921 potential glutamine specificity residues [chemical binding]; other site 1124936012922 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1124936012923 ATP Binding subdomain [chemical binding]; other site 1124936012924 Ligand Binding sites [chemical binding]; other site 1124936012925 Dimerization subdomain; other site 1124936012926 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1124936012927 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1124936012928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1124936012929 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1124936012930 active site 1124936012931 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1124936012932 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1124936012933 generic binding surface II; other site 1124936012934 generic binding surface I; other site 1124936012935 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 1124936012936 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1124936012937 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1124936012938 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1124936012939 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1124936012940 Autotransporter beta-domain; Region: Autotransporter; smart00869 1124936012941 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1124936012942 outer membrane protein RatB; Provisional; Region: PRK15314 1124936012943 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012944 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012945 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012946 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012947 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012948 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012949 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012950 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012951 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012952 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012953 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012954 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012955 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012956 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012957 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012958 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012959 outer membrane protein RatA; Provisional; Region: PRK15315 1124936012960 Oxygen tolerance; Region: BatD; pfam13584 1124936012961 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012962 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012963 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012964 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012965 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012966 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012967 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012968 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012969 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012970 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1124936012971 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1124936012972 intimin-like protein SinH; Provisional; Region: PRK15318 1124936012973 intimin-like protein SinH; Provisional; Region: PRK15318 1124936012974 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1124936012975 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1124936012976 GTP-binding protein Der; Reviewed; Region: PRK00093 1124936012977 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1124936012978 G1 box; other site 1124936012979 GTP/Mg2+ binding site [chemical binding]; other site 1124936012980 Switch I region; other site 1124936012981 G2 box; other site 1124936012982 Switch II region; other site 1124936012983 G3 box; other site 1124936012984 G4 box; other site 1124936012985 G5 box; other site 1124936012986 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1124936012987 G1 box; other site 1124936012988 GTP/Mg2+ binding site [chemical binding]; other site 1124936012989 Switch I region; other site 1124936012990 G2 box; other site 1124936012991 G3 box; other site 1124936012992 Switch II region; other site 1124936012993 G4 box; other site 1124936012994 G5 box; other site 1124936012995 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1124936012996 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1124936012997 Trp docking motif [polypeptide binding]; other site 1124936012998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1124936012999 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1124936013000 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1124936013001 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1124936013002 dimer interface [polypeptide binding]; other site 1124936013003 motif 1; other site 1124936013004 active site 1124936013005 motif 2; other site 1124936013006 motif 3; other site 1124936013007 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1124936013008 anticodon binding site; other site 1124936013009 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1124936013010 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1124936013011 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1124936013012 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1124936013013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936013014 non-specific DNA binding site [nucleotide binding]; other site 1124936013015 salt bridge; other site 1124936013016 sequence-specific DNA binding site [nucleotide binding]; other site 1124936013017 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1124936013018 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1124936013019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124936013020 FeS/SAM binding site; other site 1124936013021 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1124936013022 active site 1124936013023 multimer interface [polypeptide binding]; other site 1124936013024 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936013025 hydrogenase 4 subunit H; Validated; Region: PRK08222 1124936013026 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1124936013027 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1124936013028 4Fe-4S binding domain; Region: Fer4; pfam00037 1124936013029 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1124936013030 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1124936013031 putative [Fe4-S4] binding site [ion binding]; other site 1124936013032 putative molybdopterin cofactor binding site [chemical binding]; other site 1124936013033 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1124936013034 putative molybdopterin cofactor binding site; other site 1124936013035 penicillin-binding protein 1C; Provisional; Region: PRK11240 1124936013036 Transglycosylase; Region: Transgly; pfam00912 1124936013037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1124936013038 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1124936013039 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1124936013040 MG2 domain; Region: A2M_N; pfam01835 1124936013041 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1124936013042 surface patch; other site 1124936013043 thioester region; other site 1124936013044 specificity defining residues; other site 1124936013045 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1124936013046 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1124936013047 active site residue [active] 1124936013048 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1124936013049 active site residue [active] 1124936013050 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1124936013051 aminopeptidase B; Provisional; Region: PRK05015 1124936013052 Peptidase; Region: DUF3663; pfam12404 1124936013053 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1124936013054 interface (dimer of trimers) [polypeptide binding]; other site 1124936013055 Substrate-binding/catalytic site; other site 1124936013056 Zn-binding sites [ion binding]; other site 1124936013057 hypothetical protein; Provisional; Region: PRK10721 1124936013058 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1124936013059 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124936013060 catalytic loop [active] 1124936013061 iron binding site [ion binding]; other site 1124936013062 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1124936013063 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1124936013064 nucleotide binding site [chemical binding]; other site 1124936013065 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1124936013066 SBD interface [polypeptide binding]; other site 1124936013067 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1124936013068 DnaJ domain; Region: DnaJ; pfam00226 1124936013069 HSP70 interaction site [polypeptide binding]; other site 1124936013070 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1124936013071 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1124936013072 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1124936013073 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1124936013074 trimerization site [polypeptide binding]; other site 1124936013075 active site 1124936013076 cysteine desulfurase; Provisional; Region: PRK14012 1124936013077 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1124936013078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124936013079 catalytic residue [active] 1124936013080 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1124936013081 Rrf2 family protein; Region: rrf2_super; TIGR00738 1124936013082 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1124936013083 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1124936013084 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1124936013085 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1124936013086 active site 1124936013087 dimerization interface [polypeptide binding]; other site 1124936013088 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1124936013089 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124936013090 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 1124936013091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936013092 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1124936013093 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1124936013094 FAD binding pocket [chemical binding]; other site 1124936013095 FAD binding motif [chemical binding]; other site 1124936013096 phosphate binding motif [ion binding]; other site 1124936013097 beta-alpha-beta structure motif; other site 1124936013098 NAD binding pocket [chemical binding]; other site 1124936013099 Iron coordination center [ion binding]; other site 1124936013100 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 1124936013101 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124936013102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936013103 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1124936013104 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1124936013105 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1124936013106 PRD domain; Region: PRD; pfam00874 1124936013107 PRD domain; Region: PRD; pfam00874 1124936013108 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1124936013109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013110 putative substrate translocation pore; other site 1124936013111 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1124936013112 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1124936013113 dimer interface [polypeptide binding]; other site 1124936013114 active site 1124936013115 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1124936013116 folate binding site [chemical binding]; other site 1124936013117 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1124936013118 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1124936013119 heme-binding site [chemical binding]; other site 1124936013120 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1124936013121 FAD binding pocket [chemical binding]; other site 1124936013122 FAD binding motif [chemical binding]; other site 1124936013123 phosphate binding motif [ion binding]; other site 1124936013124 beta-alpha-beta structure motif; other site 1124936013125 NAD binding pocket [chemical binding]; other site 1124936013126 Heme binding pocket [chemical binding]; other site 1124936013127 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1124936013128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936013129 DNA binding site [nucleotide binding] 1124936013130 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1124936013131 lysine decarboxylase CadA; Provisional; Region: PRK15400 1124936013132 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1124936013133 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1124936013134 homodimer interface [polypeptide binding]; other site 1124936013135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936013136 catalytic residue [active] 1124936013137 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1124936013138 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1124936013139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013140 putative substrate translocation pore; other site 1124936013141 POT family; Region: PTR2; pfam00854 1124936013142 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1124936013143 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1124936013144 response regulator GlrR; Provisional; Region: PRK15115 1124936013145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936013146 active site 1124936013147 phosphorylation site [posttranslational modification] 1124936013148 intermolecular recognition site; other site 1124936013149 dimerization interface [polypeptide binding]; other site 1124936013150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936013151 Walker A motif; other site 1124936013152 ATP binding site [chemical binding]; other site 1124936013153 Walker B motif; other site 1124936013154 arginine finger; other site 1124936013155 hypothetical protein; Provisional; Region: PRK10722 1124936013156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124936013157 HAMP domain; Region: HAMP; pfam00672 1124936013158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936013159 dimer interface [polypeptide binding]; other site 1124936013160 phosphorylation site [posttranslational modification] 1124936013161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936013162 ATP binding site [chemical binding]; other site 1124936013163 Mg2+ binding site [ion binding]; other site 1124936013164 G-X-G motif; other site 1124936013165 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1124936013166 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1124936013167 dimerization interface [polypeptide binding]; other site 1124936013168 ATP binding site [chemical binding]; other site 1124936013169 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 1124936013170 dimerization interface [polypeptide binding]; other site 1124936013171 ATP binding site [chemical binding]; other site 1124936013172 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1124936013173 putative active site [active] 1124936013174 catalytic triad [active] 1124936013175 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1124936013176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124936013177 substrate binding pocket [chemical binding]; other site 1124936013178 membrane-bound complex binding site; other site 1124936013179 hinge residues; other site 1124936013180 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936013181 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936013182 catalytic residue [active] 1124936013183 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1124936013184 nucleoside/Zn binding site; other site 1124936013185 dimer interface [polypeptide binding]; other site 1124936013186 catalytic motif [active] 1124936013187 hypothetical protein; Provisional; Region: PRK11590 1124936013188 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1124936013189 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1124936013190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124936013191 active site turn [active] 1124936013192 phosphorylation site [posttranslational modification] 1124936013193 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124936013194 potential frameshift: common BLAST hit: gi|194445313|ref|YP_002041834.1| N-acetylmuramic acid 6-phosphate etherase 1124936013195 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124936013196 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1124936013197 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124936013198 putative active site [active] 1124936013199 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1124936013200 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1124936013201 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1124936013202 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1124936013203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013204 putative substrate translocation pore; other site 1124936013205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936013206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936013207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936013208 dimerization interface [polypeptide binding]; other site 1124936013209 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1124936013210 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1124936013211 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1124936013212 active site 1124936013213 hydrophilic channel; other site 1124936013214 dimerization interface [polypeptide binding]; other site 1124936013215 catalytic residues [active] 1124936013216 active site lid [active] 1124936013217 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1124936013218 Recombination protein O N terminal; Region: RecO_N; pfam11967 1124936013219 Recombination protein O C terminal; Region: RecO_C; pfam02565 1124936013220 GTPase Era; Reviewed; Region: era; PRK00089 1124936013221 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1124936013222 G1 box; other site 1124936013223 GTP/Mg2+ binding site [chemical binding]; other site 1124936013224 Switch I region; other site 1124936013225 G2 box; other site 1124936013226 Switch II region; other site 1124936013227 G3 box; other site 1124936013228 G4 box; other site 1124936013229 G5 box; other site 1124936013230 KH domain; Region: KH_2; pfam07650 1124936013231 ribonuclease III; Reviewed; Region: rnc; PRK00102 1124936013232 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1124936013233 dimerization interface [polypeptide binding]; other site 1124936013234 active site 1124936013235 metal binding site [ion binding]; metal-binding site 1124936013236 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1124936013237 dsRNA binding site [nucleotide binding]; other site 1124936013238 signal peptidase I; Provisional; Region: PRK10861 1124936013239 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1124936013240 Catalytic site [active] 1124936013241 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1124936013242 GTP-binding protein LepA; Provisional; Region: PRK05433 1124936013243 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1124936013244 G1 box; other site 1124936013245 putative GEF interaction site [polypeptide binding]; other site 1124936013246 GTP/Mg2+ binding site [chemical binding]; other site 1124936013247 Switch I region; other site 1124936013248 G2 box; other site 1124936013249 G3 box; other site 1124936013250 Switch II region; other site 1124936013251 G4 box; other site 1124936013252 G5 box; other site 1124936013253 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1124936013254 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1124936013255 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1124936013256 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1124936013257 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1124936013258 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1124936013259 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1124936013260 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1124936013261 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1124936013262 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1124936013263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124936013264 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124936013265 DNA binding residues [nucleotide binding] 1124936013266 L-aspartate oxidase; Provisional; Region: PRK09077 1124936013267 L-aspartate oxidase; Provisional; Region: PRK06175 1124936013268 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1124936013269 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1124936013270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936013271 S-adenosylmethionine binding site [chemical binding]; other site 1124936013272 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1124936013273 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124936013274 ATP binding site [chemical binding]; other site 1124936013275 Mg++ binding site [ion binding]; other site 1124936013276 motif III; other site 1124936013277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124936013278 nucleotide binding region [chemical binding]; other site 1124936013279 ATP-binding site [chemical binding]; other site 1124936013280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936013281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936013282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124936013283 dimerization interface [polypeptide binding]; other site 1124936013284 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1124936013285 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1124936013286 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1124936013287 ligand binding site [chemical binding]; other site 1124936013288 active site 1124936013289 UGI interface [polypeptide binding]; other site 1124936013290 catalytic site [active] 1124936013291 putative methyltransferase; Provisional; Region: PRK10864 1124936013292 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1124936013293 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1124936013294 thioredoxin 2; Provisional; Region: PRK10996 1124936013295 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1124936013296 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1124936013297 catalytic residues [active] 1124936013298 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1124936013299 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1124936013300 CoA binding domain; Region: CoA_binding_2; pfam13380 1124936013301 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1124936013302 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1124936013303 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124936013304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124936013305 Coenzyme A binding pocket [chemical binding]; other site 1124936013306 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1124936013307 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1124936013308 domain interface [polypeptide binding]; other site 1124936013309 putative active site [active] 1124936013310 catalytic site [active] 1124936013311 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1124936013312 domain interface [polypeptide binding]; other site 1124936013313 putative active site [active] 1124936013314 catalytic site [active] 1124936013315 lipoprotein; Provisional; Region: PRK10759 1124936013316 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1124936013317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013318 putative substrate translocation pore; other site 1124936013319 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1124936013320 protein disaggregation chaperone; Provisional; Region: PRK10865 1124936013321 Clp amino terminal domain; Region: Clp_N; pfam02861 1124936013322 Clp amino terminal domain; Region: Clp_N; pfam02861 1124936013323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936013324 Walker A motif; other site 1124936013325 ATP binding site [chemical binding]; other site 1124936013326 Walker B motif; other site 1124936013327 arginine finger; other site 1124936013328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936013329 Walker A motif; other site 1124936013330 ATP binding site [chemical binding]; other site 1124936013331 Walker B motif; other site 1124936013332 arginine finger; other site 1124936013333 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1124936013334 hypothetical protein; Provisional; Region: PRK10723 1124936013335 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1124936013336 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1124936013337 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124936013338 RNA binding surface [nucleotide binding]; other site 1124936013339 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1124936013340 active site 1124936013341 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1124936013342 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1124936013343 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1124936013344 30S subunit binding site; other site 1124936013345 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1124936013346 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1124936013347 Prephenate dehydratase; Region: PDT; pfam00800 1124936013348 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1124936013349 putative L-Phe binding site [chemical binding]; other site 1124936013350 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1124936013351 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1124936013352 Chorismate mutase type II; Region: CM_2; cl00693 1124936013353 prephenate dehydrogenase; Validated; Region: PRK08507 1124936013354 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1124936013355 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124936013356 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1124936013357 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1124936013358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124936013359 metal binding site [ion binding]; metal-binding site 1124936013360 active site 1124936013361 I-site; other site 1124936013362 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1124936013363 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1124936013364 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1124936013365 RimM N-terminal domain; Region: RimM; pfam01782 1124936013366 PRC-barrel domain; Region: PRC; pfam05239 1124936013367 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1124936013368 signal recognition particle protein; Provisional; Region: PRK10867 1124936013369 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1124936013370 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1124936013371 P loop; other site 1124936013372 GTP binding site [chemical binding]; other site 1124936013373 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1124936013374 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1124936013375 hypothetical protein; Provisional; Region: PRK11573 1124936013376 Domain of unknown function DUF21; Region: DUF21; pfam01595 1124936013377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124936013378 Transporter associated domain; Region: CorC_HlyC; smart01091 1124936013379 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1124936013380 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1124936013381 dimer interface [polypeptide binding]; other site 1124936013382 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1124936013383 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1124936013384 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1124936013385 recombination and repair protein; Provisional; Region: PRK10869 1124936013386 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1124936013387 Walker A/P-loop; other site 1124936013388 ATP binding site [chemical binding]; other site 1124936013389 Q-loop/lid; other site 1124936013390 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1124936013391 ABC transporter signature motif; other site 1124936013392 Walker B; other site 1124936013393 D-loop; other site 1124936013394 H-loop/switch region; other site 1124936013395 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1124936013396 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1124936013397 hypothetical protein; Validated; Region: PRK01777 1124936013398 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1124936013399 putative coenzyme Q binding site [chemical binding]; other site 1124936013400 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1124936013401 SmpB-tmRNA interface; other site 1124936013402 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013403 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013404 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013405 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013406 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013407 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013408 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013409 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013410 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013411 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013412 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013413 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936013414 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013415 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013416 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1124936013417 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013418 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1124936013419 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1124936013420 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124936013421 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1124936013422 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936013423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936013424 Walker A/P-loop; other site 1124936013425 ATP binding site [chemical binding]; other site 1124936013426 Q-loop/lid; other site 1124936013427 ABC transporter signature motif; other site 1124936013428 Walker B; other site 1124936013429 D-loop; other site 1124936013430 H-loop/switch region; other site 1124936013431 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1124936013432 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936013433 DNA-directed RNA polymerase II subunit 7; Provisional; Region: PTZ00162 1124936013434 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1124936013435 active site 1124936013436 Int/Topo IB signature motif; other site 1124936013437 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936013438 SEC-C motif; Region: SEC-C; pfam02810 1124936013439 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1124936013440 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1124936013441 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1124936013442 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124936013443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124936013444 non-specific DNA binding site [nucleotide binding]; other site 1124936013445 salt bridge; other site 1124936013446 sequence-specific DNA binding site [nucleotide binding]; other site 1124936013447 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1124936013448 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 1124936013449 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 1124936013450 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1124936013451 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1124936013452 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1124936013453 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124936013454 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124936013455 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124936013456 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1124936013457 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1124936013458 active site 1124936013459 dimer interface [polypeptide binding]; other site 1124936013460 magnesium binding site [ion binding]; other site 1124936013461 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1124936013462 tetramer interface [polypeptide binding]; other site 1124936013463 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124936013464 active site 1124936013465 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 1124936013466 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1124936013467 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124936013468 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1124936013469 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124936013470 active site turn [active] 1124936013471 phosphorylation site [posttranslational modification] 1124936013472 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1124936013473 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1124936013474 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1124936013475 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1124936013476 Integrase; Region: Integrase_1; pfam12835 1124936013477 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124936013478 Integrase core domain; Region: rve; pfam00665 1124936013479 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1124936013480 DNA-binding interface [nucleotide binding]; DNA binding site 1124936013481 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1124936013482 Family description; Region: UvrD_C_2; pfam13538 1124936013483 Transposase; Region: HTH_Tnp_1; cl17663 1124936013484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1124936013485 putative transposase OrfB; Reviewed; Region: PHA02517 1124936013486 HTH-like domain; Region: HTH_21; pfam13276 1124936013487 Integrase core domain; Region: rve; pfam00665 1124936013488 Integrase core domain; Region: rve_2; pfam13333 1124936013489 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 1124936013490 flagellin; Validated; Region: PRK08026 1124936013491 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1124936013492 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1124936013493 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1124936013494 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1124936013495 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1124936013496 catalytic residues [active] 1124936013497 catalytic nucleophile [active] 1124936013498 Presynaptic Site I dimer interface [polypeptide binding]; other site 1124936013499 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1124936013500 Synaptic Flat tetramer interface [polypeptide binding]; other site 1124936013501 Synaptic Site I dimer interface [polypeptide binding]; other site 1124936013502 DNA binding site [nucleotide binding] 1124936013503 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1124936013504 DNA-binding interface [nucleotide binding]; DNA binding site 1124936013505 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1124936013506 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1124936013507 homodimer interface [polypeptide binding]; other site 1124936013508 active site 1124936013509 TDP-binding site; other site 1124936013510 acceptor substrate-binding pocket; other site 1124936013511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936013512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936013513 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1124936013514 Walker A/P-loop; other site 1124936013515 ATP binding site [chemical binding]; other site 1124936013516 Q-loop/lid; other site 1124936013517 ABC transporter signature motif; other site 1124936013518 Walker B; other site 1124936013519 D-loop; other site 1124936013520 H-loop/switch region; other site 1124936013521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1124936013522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124936013523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124936013524 Walker A/P-loop; other site 1124936013525 ATP binding site [chemical binding]; other site 1124936013526 Q-loop/lid; other site 1124936013527 ABC transporter signature motif; other site 1124936013528 Walker B; other site 1124936013529 D-loop; other site 1124936013530 H-loop/switch region; other site 1124936013531 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1124936013532 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1124936013533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124936013534 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1124936013535 outer membrane receptor FepA; Provisional; Region: PRK13528 1124936013536 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124936013537 N-terminal plug; other site 1124936013538 ligand-binding site [chemical binding]; other site 1124936013539 secreted effector protein PipB2; Provisional; Region: PRK15196 1124936013540 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936013541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936013542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936013543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936013544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124936013545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1124936013546 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1124936013547 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1124936013548 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1124936013549 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1124936013550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124936013551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124936013552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124936013553 dimer interface [polypeptide binding]; other site 1124936013554 phosphorylation site [posttranslational modification] 1124936013555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124936013556 ATP binding site [chemical binding]; other site 1124936013557 Mg2+ binding site [ion binding]; other site 1124936013558 G-X-G motif; other site 1124936013559 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1124936013560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124936013561 active site 1124936013562 phosphorylation site [posttranslational modification] 1124936013563 intermolecular recognition site; other site 1124936013564 dimerization interface [polypeptide binding]; other site 1124936013565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936013566 DNA binding site [nucleotide binding] 1124936013567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1124936013568 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1124936013569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1124936013570 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1124936013571 substrate binding pocket [chemical binding]; other site 1124936013572 active site 1124936013573 iron coordination sites [ion binding]; other site 1124936013574 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1124936013575 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124936013576 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1124936013577 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1124936013578 tetramerization interface [polypeptide binding]; other site 1124936013579 NAD(P) binding site [chemical binding]; other site 1124936013580 catalytic residues [active] 1124936013581 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1124936013582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124936013583 inhibitor-cofactor binding pocket; inhibition site 1124936013584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936013585 catalytic residue [active] 1124936013586 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1124936013587 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1124936013588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936013589 DNA-binding site [nucleotide binding]; DNA binding site 1124936013590 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124936013591 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1124936013592 bacterial OsmY and nodulation domain; Region: BON; smart00749 1124936013593 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936013594 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1124936013595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124936013596 dimerization interface [polypeptide binding]; other site 1124936013597 putative DNA binding site [nucleotide binding]; other site 1124936013598 putative Zn2+ binding site [ion binding]; other site 1124936013599 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1124936013600 active site residue [active] 1124936013601 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1124936013602 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1124936013603 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1124936013604 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1124936013605 hypothetical protein; Provisional; Region: PRK10556 1124936013606 hypothetical protein; Provisional; Region: PRK10132 1124936013607 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124936013608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124936013609 DNA-binding site [nucleotide binding]; DNA binding site 1124936013610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124936013611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124936013612 homodimer interface [polypeptide binding]; other site 1124936013613 catalytic residue [active] 1124936013614 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1124936013615 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1124936013616 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1124936013617 catalytic residues [active] 1124936013618 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1124936013619 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1124936013620 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1124936013621 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1124936013622 active site 1124936013623 dimer interface [polypeptide binding]; other site 1124936013624 catalytic residues [active] 1124936013625 effector binding site; other site 1124936013626 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1124936013627 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1124936013628 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1124936013629 dimer interface [polypeptide binding]; other site 1124936013630 putative radical transfer pathway; other site 1124936013631 diiron center [ion binding]; other site 1124936013632 tyrosyl radical; other site 1124936013633 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1124936013634 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1124936013635 Walker A/P-loop; other site 1124936013636 ATP binding site [chemical binding]; other site 1124936013637 Q-loop/lid; other site 1124936013638 ABC transporter signature motif; other site 1124936013639 Walker B; other site 1124936013640 D-loop; other site 1124936013641 H-loop/switch region; other site 1124936013642 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1124936013643 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1124936013644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124936013645 dimer interface [polypeptide binding]; other site 1124936013646 conserved gate region; other site 1124936013647 putative PBP binding loops; other site 1124936013648 ABC-ATPase subunit interface; other site 1124936013649 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1124936013650 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1124936013651 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124936013652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013653 transcriptional repressor MprA; Provisional; Region: PRK10870 1124936013654 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124936013655 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1124936013656 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124936013657 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124936013658 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124936013659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013660 putative substrate translocation pore; other site 1124936013661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013662 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1124936013663 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1124936013664 glutamate--cysteine ligase; Provisional; Region: PRK02107 1124936013665 Predicted membrane protein [Function unknown]; Region: COG1238 1124936013666 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1124936013667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124936013668 motif II; other site 1124936013669 potential protein location (hypothetical protein SEEH1578_22925 [Salmonella enterica subsp. enterica serovar Heidelberg str. CFSAN000318]) that overlaps RNA (tRNA-R) 1124936013670 carbon storage regulator; Provisional; Region: PRK01712 1124936013671 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1124936013672 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1124936013673 motif 1; other site 1124936013674 active site 1124936013675 motif 2; other site 1124936013676 motif 3; other site 1124936013677 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1124936013678 DHHA1 domain; Region: DHHA1; pfam02272 1124936013679 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1124936013680 recombinase A; Provisional; Region: recA; PRK09354 1124936013681 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1124936013682 hexamer interface [polypeptide binding]; other site 1124936013683 Walker A motif; other site 1124936013684 ATP binding site [chemical binding]; other site 1124936013685 Walker B motif; other site 1124936013686 hypothetical protein; Validated; Region: PRK03661 1124936013687 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1124936013688 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936013689 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936013690 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1124936013691 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1124936013692 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1124936013693 Nucleoside recognition; Region: Gate; pfam07670 1124936013694 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1124936013695 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1124936013696 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1124936013697 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1124936013698 putative NAD(P) binding site [chemical binding]; other site 1124936013699 active site 1124936013700 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1124936013701 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1124936013702 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124936013703 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936013704 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1124936013705 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1124936013706 putative active site [active] 1124936013707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1124936013708 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1124936013709 GAF domain; Region: GAF; pfam01590 1124936013710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936013711 Walker A motif; other site 1124936013712 ATP binding site [chemical binding]; other site 1124936013713 Walker B motif; other site 1124936013714 arginine finger; other site 1124936013715 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1124936013716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1124936013717 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1124936013718 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1124936013719 iron binding site [ion binding]; other site 1124936013720 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1124936013721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124936013722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124936013723 Acylphosphatase; Region: Acylphosphatase; pfam00708 1124936013724 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1124936013725 HypF finger; Region: zf-HYPF; pfam07503 1124936013726 HypF finger; Region: zf-HYPF; pfam07503 1124936013727 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1124936013728 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1124936013729 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1124936013730 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1124936013731 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1124936013732 nickel binding site [ion binding]; other site 1124936013733 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1124936013734 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1124936013735 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1124936013736 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124936013737 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1124936013738 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1124936013739 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1124936013740 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1124936013741 NADH dehydrogenase; Region: NADHdh; cl00469 1124936013742 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1124936013743 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124936013744 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1124936013745 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1124936013746 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1124936013747 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1124936013748 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1124936013749 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1124936013750 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1124936013751 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1124936013752 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1124936013753 dimerization interface [polypeptide binding]; other site 1124936013754 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1124936013755 ATP binding site [chemical binding]; other site 1124936013756 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1124936013757 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1124936013758 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1124936013759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124936013760 Walker A motif; other site 1124936013761 ATP binding site [chemical binding]; other site 1124936013762 Walker B motif; other site 1124936013763 arginine finger; other site 1124936013764 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124936013765 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1124936013766 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1124936013767 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1124936013768 metal binding site [ion binding]; metal-binding site 1124936013769 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1124936013770 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1124936013771 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1124936013772 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936013773 ABC-ATPase subunit interface; other site 1124936013774 dimer interface [polypeptide binding]; other site 1124936013775 putative PBP binding regions; other site 1124936013776 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1124936013777 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124936013778 ABC-ATPase subunit interface; other site 1124936013779 dimer interface [polypeptide binding]; other site 1124936013780 putative PBP binding regions; other site 1124936013781 effector protein YopJ; Provisional; Region: PRK15371 1124936013782 transcriptional activator SprB; Provisional; Region: PRK15320 1124936013783 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1124936013784 transcriptional regulator SirC; Provisional; Region: PRK15044 1124936013785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936013786 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 1124936013787 invasion protein OrgB; Provisional; Region: PRK15322 1124936013788 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1124936013789 invasion protein OrgA; Provisional; Region: PRK15323 1124936013790 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 1124936013791 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1124936013792 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 1124936013793 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 1124936013794 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1124936013795 transcriptional regulator HilD; Provisional; Region: PRK15185 1124936013796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124936013797 invasion protein regulator; Provisional; Region: PRK12370 1124936013798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124936013799 DNA binding site [nucleotide binding] 1124936013800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124936013801 binding surface 1124936013802 TPR motif; other site 1124936013803 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1124936013804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936013805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936013806 catalytic residue [active] 1124936013807 potential frameshift: common BLAST hit: gi|383497553|ref|YP_005398242.1| tyrosine phosphatase (associated with virulence) 1124936013808 chaperone protein SicP; Provisional; Region: PRK15329 1124936013809 putative acyl carrier protein IacP; Validated; Region: PRK08172 1124936013810 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 1124936013811 cell invasion protein SipD; Provisional; Region: PRK15330 1124936013812 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 1124936013813 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1124936013814 chaperone protein SicA; Provisional; Region: PRK15331 1124936013815 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1124936013816 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1124936013817 type III secretion system protein SpaS; Validated; Region: PRK08156 1124936013818 type III secretion system protein SpaR; Provisional; Region: PRK15332 1124936013819 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1124936013820 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1124936013821 type III secretion system protein SpaO; Validated; Region: PRK08158 1124936013822 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1124936013823 antigen presentation protein SpaN; Provisional; Region: PRK15334 1124936013824 Surface presentation of antigens protein; Region: SPAN; pfam02510 1124936013825 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 1124936013826 ATP synthase SpaL; Validated; Region: PRK08149 1124936013827 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1124936013828 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124936013829 Walker A motif; other site 1124936013830 ATP binding site [chemical binding]; other site 1124936013831 Walker B motif; other site 1124936013832 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 1124936013833 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1124936013834 type III secretion system protein InvA; Provisional; Region: PRK15337 1124936013835 type III secretion system regulator InvE; Provisional; Region: PRK15338 1124936013836 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1124936013837 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1124936013838 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124936013839 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124936013840 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124936013841 transcriptional regulator InvF; Provisional; Region: PRK15340 1124936013842 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1124936013843 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1124936013844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1124936013845 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1124936013846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124936013847 active site 1124936013848 metal binding site [ion binding]; metal-binding site 1124936013849 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1124936013850 MutS domain I; Region: MutS_I; pfam01624 1124936013851 MutS domain II; Region: MutS_II; pfam05188 1124936013852 MutS domain III; Region: MutS_III; pfam05192 1124936013853 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1124936013854 Walker A/P-loop; other site 1124936013855 ATP binding site [chemical binding]; other site 1124936013856 Q-loop/lid; other site 1124936013857 ABC transporter signature motif; other site 1124936013858 Walker B; other site 1124936013859 D-loop; other site 1124936013860 H-loop/switch region; other site 1124936013861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1124936013862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936013863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936013864 putative substrate translocation pore; other site 1124936013865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124936013866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124936013867 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124936013868 putative effector binding pocket; other site 1124936013869 dimerization interface [polypeptide binding]; other site 1124936013870 GntP family permease; Region: GntP_permease; pfam02447 1124936013871 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124936013872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124936013873 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1124936013874 putative NAD(P) binding site [chemical binding]; other site 1124936013875 active site 1124936013876 putative substrate binding site [chemical binding]; other site 1124936013877 hypothetical protein; Provisional; Region: PRK09989 1124936013878 putative aldolase; Validated; Region: PRK08130 1124936013879 intersubunit interface [polypeptide binding]; other site 1124936013880 active site 1124936013881 Zn2+ binding site [ion binding]; other site 1124936013882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1124936013883 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1124936013884 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124936013885 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124936013886 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124936013887 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124936013888 MarR family; Region: MarR_2; cl17246 1124936013889 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1124936013890 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1124936013891 Flavoprotein; Region: Flavoprotein; pfam02441 1124936013892 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1124936013893 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1124936013894 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1124936013895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124936013896 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1124936013897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124936013898 DNA binding residues [nucleotide binding] 1124936013899 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1124936013900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124936013901 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124936013902 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1124936013903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124936013904 S-adenosylmethionine binding site [chemical binding]; other site 1124936013905 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1124936013906 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1124936013907 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1124936013908 Permutation of conserved domain; other site 1124936013909 active site 1124936013910 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1124936013911 plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525 1124936013912 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124936013913 Walker A motif; other site 1124936013914 ATP binding site [chemical binding]; other site 1124936013915 Walker B motif; other site 1124936013916 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 1124936013917 PLD-like domain; Region: PLDc_2; pfam13091 1124936013918 putative active site [active] 1124936013919 catalytic site [active] 1124936013920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1124936013921 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1124936013922 active site 1124936013923 metal binding site [ion binding]; metal-binding site 1124936013924 interdomain interaction site; other site 1124936013925 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 1124936013926 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 1124936013927 AAA-like domain; Region: AAA_10; pfam12846 1124936013928 indole-3-acetamide amidohydrolase; Region: PLN02722 1124936013929 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1124936013930 HEAT repeats; Region: HEAT_2; pfam13646 1124936013931 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1124936013932 Hok/gef family; Region: HOK_GEF; pfam01848 1124936013933 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1124936013934 dimerization domain [polypeptide binding]; other site 1124936013935 dimer interface [polypeptide binding]; other site 1124936013936 catalytic residues [active] 1124936013937 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1124936013938 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1124936013939 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1124936013940 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1124936013941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1124936013942 non-specific DNA binding site [nucleotide binding]; other site 1124936013943 salt bridge; other site 1124936013944 sequence-specific DNA binding site [nucleotide binding]; other site 1124936013945 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1124936013946 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1124936013947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1124936013948 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1124936013949 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1124936013950 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1124936013951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1124936013952 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1124936013953 Transposase; Region: HTH_Tnp_1; pfam01527 1124936013954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1124936013955 putative transposase; Provisional; Region: PRK09857 1124936013956 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1124936013957 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1124936013958 PsiA protein; Region: PsiA; cl11646 1124936013959 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 1124936013960 ParB-like nuclease domain; Region: ParB; smart00470 1124936013961 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1124936013962 KorB domain; Region: KorB; pfam08535 1124936013963 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1124936013964 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1124936013965 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1124936013966 dimer interface [polypeptide binding]; other site 1124936013967 ssDNA binding site [nucleotide binding]; other site 1124936013968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124936013969 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1124936013970 Antirestriction protein; Region: Antirestrict; pfam03230 1124936013971 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1124936013972 putative methylase; Provisional; Region: PRK13699 1124936013973 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1124936013974 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 1124936013975 DinI-like family; Region: DinI; cl11630 1124936013976 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 1124936013977 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1124936013978 Mg binding site [ion binding]; other site 1124936013979 nucleotide binding site [chemical binding]; other site 1124936013980 putative protofilament interface [polypeptide binding]; other site 1124936013981 ParA-like protein; Provisional; Region: PHA02518 1124936013982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124936013983 P-loop; other site 1124936013984 Magnesium ion binding site [ion binding]; other site 1124936013985 Phage integrase family; Region: Phage_integrase; pfam00589 1124936013986 active site 1124936013987 DNA binding site [nucleotide binding] 1124936013988 Int/Topo IB signature motif; other site 1124936013989 Colicin Ia; Region: Colicin_Ia; pfam11504 1124936013990 Colicin pore forming domain; Region: Colicin; pfam01024 1124936013991 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 1124936013992 putative kissing complex interaction region; other site 1124936013993 putative RNA binding sites [nucleotide binding]; other site 1124936013994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1124936013995 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1124936013996 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1124936013997 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1124936013998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1124936013999 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1124936014000 Integrase core domain; Region: rve; pfam00665 1124936014001 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1124936014002 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1124936014003 AAA domain; Region: AAA_18; pfam13238 1124936014004 active site 1124936014005 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1124936014006 Transposase domain (DUF772); Region: DUF772; pfam05598 1124936014007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1124936014008 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1124936014009 beta-lactamase TEM; Provisional; Region: PRK15442 1124936014010 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1124936014011 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1124936014012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1124936014013 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1124936014014 Integrase core domain; Region: rve; pfam00665 1124936014015 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 1124936014016 DNA binding site [nucleotide binding] 1124936014017 EcoRII C terminal; Region: EcoRII-C; pfam09019 1124936014018 DNA cytosine methylase; Provisional; Region: PRK10458 1124936014019 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1124936014020 cofactor binding site; other site 1124936014021 DNA binding site [nucleotide binding] 1124936014022 substrate interaction site [chemical binding]; other site 1124936014023 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1124936014024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1124936014025 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1124936014026 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1124936014027 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 1124936014028 aminoglycoside resistance protein; Provisional; Region: PRK13746 1124936014029 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1124936014030 active site 1124936014031 NTP binding site [chemical binding]; other site 1124936014032 metal binding triad [ion binding]; metal-binding site 1124936014033 antibiotic binding site [chemical binding]; other site 1124936014034 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1124936014035 integrase/recombinase; Provisional; Region: PRK15417 1124936014036 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1124936014037 Int/Topo IB signature motif; other site 1124936014038 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1124936014039 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1124936014040 catalytic residues [active] 1124936014041 catalytic nucleophile [active] 1124936014042 Presynaptic Site I dimer interface [polypeptide binding]; other site 1124936014043 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1124936014044 Synaptic Flat tetramer interface [polypeptide binding]; other site 1124936014045 Synaptic Site I dimer interface [polypeptide binding]; other site 1124936014046 DNA binding site [nucleotide binding] 1124936014047 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1124936014048 DNA-binding interface [nucleotide binding]; DNA binding site 1124936014049 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1124936014050 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1124936014051 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1124936014052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124936014053 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1124936014054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124936014055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124936014056 putative substrate translocation pore; other site 1124936014057 EamA-like transporter family; Region: EamA; pfam00892 1124936014058 EamA-like transporter family; Region: EamA; pfam00892 1124936014059 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1124936014060 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1124936014061 active site 1124936014062 catalytic site [active] 1124936014063 substrate binding site [chemical binding]; other site 1124936014064 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1124936014065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1124936014066 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1124936014067 IncFII RepA protein family; Region: IncFII_repA; cl11495 1124936014068 Ash protein family; Region: Phage_ASH; pfam10554 1124936014069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1124936014070 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 1124936014071 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 1124936014072 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 1124936014073 Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623 1124936014074 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1124936014075 PilM; Region: PilM; pfam07419 1124936014076 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1124936014077 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 1124936014078 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124936014079 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1124936014080 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1124936014081 Type II/IV secretion system protein; Region: T2SE; pfam00437 1124936014082 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124936014083 Walker A motif; other site 1124936014084 ATP binding site [chemical binding]; other site 1124936014085 Walker B motif; other site 1124936014086 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124936014087 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124936014088 PilS N terminal; Region: PilS; pfam08805 1124936014089 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1124936014090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936014091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936014092 catalytic residue [active] 1124936014093 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1124936014094 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1124936014095 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 1124936014096 catalytic residues [active] 1124936014097 Int/Topo IB signature motif; other site 1124936014098 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1124936014099 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1124936014100 catalytic core [active] 1124936014101 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1124936014102 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1124936014103 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1124936014104 TrbC/VIRB2 family; Region: TrbC; pfam04956 1124936014105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124936014106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124936014107 catalytic residue [active] 1124936014108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1124936014109 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1124936014110 DNA binding residues [nucleotide binding] 1124936014111 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1124936014112 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1124936014113 HicB family; Region: HicB; pfam05534 1124936014114 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1124936014115 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124936014116 HSP70 interaction site [polypeptide binding]; other site 1124936014117 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1124936014118 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1124936014119 primosomal protein DnaI; Provisional; Region: PRK02854 1124936014120 RelB antitoxin; Region: RelB; cl01171 1124936014121 Initiator Replication protein; Region: Rep_3; pfam01051 1124936014122 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1124936014123 ParA-like protein; Provisional; Region: PHA02518 1124936014124 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124936014125 P-loop; other site 1124936014126 Magnesium ion binding site [ion binding]; other site 1124936014127 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1124936014128 active site 1124936014129 catalytic residues [active] 1124936014130 DNA binding site [nucleotide binding] 1124936014131 Int/Topo IB signature motif; other site 1124936014132 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1124936014133 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1124936014134 Haemolysin expression modulating protein; Region: HHA; pfam05321 1124936014135 DNA topoisomerase III; Provisional; Region: PRK07726 1124936014136 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1124936014137 active site 1124936014138 putative interdomain interaction site [polypeptide binding]; other site 1124936014139 putative metal-binding site [ion binding]; other site 1124936014140 putative nucleotide binding site [chemical binding]; other site 1124936014141 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1124936014142 domain I; other site 1124936014143 DNA binding groove [nucleotide binding] 1124936014144 phosphate binding site [ion binding]; other site 1124936014145 domain II; other site 1124936014146 domain III; other site 1124936014147 nucleotide binding site [chemical binding]; other site 1124936014148 catalytic site [active] 1124936014149 domain IV; other site 1124936014150 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1124936014151 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1124936014152 Staphylococcal nuclease homologues; Region: SNc; smart00318 1124936014153 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1124936014154 Catalytic site; other site 1124936014155 TrbM; Region: TrbM; pfam07424 1124936014156 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 1124936014157 type IV secretion system component VirD4; Provisional; Region: PRK13897 1124936014158 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124936014159 Walker A motif; other site 1124936014160 ATP binding site [chemical binding]; other site 1124936014161 Walker B motif; other site 1124936014162 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1124936014163 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1124936014164 Walker A motif; other site 1124936014165 hexamer interface [polypeptide binding]; other site 1124936014166 ATP binding site [chemical binding]; other site 1124936014167 Walker B motif; other site 1124936014168 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1124936014169 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1124936014170 VirB7 interaction site; other site 1124936014171 VirB8 protein; Region: VirB8; pfam04335 1124936014172 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1124936014173 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1124936014174 Type IV secretion system proteins; Region: T4SS; pfam07996 1124936014175 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1124936014176 MbeB-like, N-term conserved region; Region: MbeB_N; pfam04837 1124936014177 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713