-- dump date 20140620_051847 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1160717000001 FMN-binding protein MioC; Provisional; Region: PRK09004 1160717000002 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1160717000003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717000004 putative DNA binding site [nucleotide binding]; other site 1160717000005 putative Zn2+ binding site [ion binding]; other site 1160717000006 AsnC family; Region: AsnC_trans_reg; pfam01037 1160717000007 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1160717000008 dimer interface [polypeptide binding]; other site 1160717000009 active site 1160717000010 hypothetical protein; Provisional; Region: yieM; PRK10997 1160717000011 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1160717000012 metal ion-dependent adhesion site (MIDAS); other site 1160717000013 regulatory ATPase RavA; Provisional; Region: PRK13531 1160717000014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717000015 Walker A motif; other site 1160717000016 ATP binding site [chemical binding]; other site 1160717000017 Walker B motif; other site 1160717000018 arginine finger; other site 1160717000019 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1160717000020 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1160717000021 potassium uptake protein; Region: kup; TIGR00794 1160717000022 D-ribose pyranase; Provisional; Region: PRK11797 1160717000023 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1160717000024 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1160717000025 Walker A/P-loop; other site 1160717000026 ATP binding site [chemical binding]; other site 1160717000027 Q-loop/lid; other site 1160717000028 ABC transporter signature motif; other site 1160717000029 Walker B; other site 1160717000030 D-loop; other site 1160717000031 H-loop/switch region; other site 1160717000032 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1160717000033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1160717000034 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1160717000035 TM-ABC transporter signature motif; other site 1160717000036 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1160717000037 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1160717000038 ligand binding site [chemical binding]; other site 1160717000039 dimerization interface [polypeptide binding]; other site 1160717000040 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717000041 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1160717000042 substrate binding site [chemical binding]; other site 1160717000043 dimer interface [polypeptide binding]; other site 1160717000044 ATP binding site [chemical binding]; other site 1160717000045 transcriptional repressor RbsR; Provisional; Region: PRK10423 1160717000046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717000047 DNA binding site [nucleotide binding] 1160717000048 domain linker motif; other site 1160717000049 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1160717000050 dimerization interface [polypeptide binding]; other site 1160717000051 ligand binding site [chemical binding]; other site 1160717000052 putative transporter; Provisional; Region: PRK10504 1160717000053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717000054 putative substrate translocation pore; other site 1160717000055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717000056 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1160717000057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717000058 DNA-binding site [nucleotide binding]; DNA binding site 1160717000059 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1160717000060 transcriptional regulator HdfR; Provisional; Region: PRK03601 1160717000061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717000062 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1160717000063 dimerization interface [polypeptide binding]; other site 1160717000064 hypothetical protein; Provisional; Region: PRK11027 1160717000065 putative ATP-dependent protease; Provisional; Region: PRK09862 1160717000066 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1160717000067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717000068 Walker A motif; other site 1160717000069 ATP binding site [chemical binding]; other site 1160717000070 Walker B motif; other site 1160717000071 arginine finger; other site 1160717000072 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1160717000073 ilvG operon leader peptide; Provisional; Region: PRK10424 1160717000074 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1160717000075 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1160717000076 PYR/PP interface [polypeptide binding]; other site 1160717000077 dimer interface [polypeptide binding]; other site 1160717000078 TPP binding site [chemical binding]; other site 1160717000079 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1160717000080 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1160717000081 TPP-binding site [chemical binding]; other site 1160717000082 dimer interface [polypeptide binding]; other site 1160717000083 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1160717000084 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1160717000085 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1160717000086 homodimer interface [polypeptide binding]; other site 1160717000087 substrate-cofactor binding pocket; other site 1160717000088 catalytic residue [active] 1160717000089 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1160717000090 threonine dehydratase; Reviewed; Region: PRK09224 1160717000091 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1160717000092 tetramer interface [polypeptide binding]; other site 1160717000093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717000094 catalytic residue [active] 1160717000095 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1160717000096 putative Ile/Val binding site [chemical binding]; other site 1160717000097 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1160717000098 putative Ile/Val binding site [chemical binding]; other site 1160717000099 Phage-related protein [Function unknown]; Region: COG4679 1160717000100 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1160717000101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717000102 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1160717000103 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1160717000104 putative dimerization interface [polypeptide binding]; other site 1160717000105 ketol-acid reductoisomerase; Validated; Region: PRK05225 1160717000106 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1160717000107 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1160717000108 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1160717000109 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1160717000110 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1160717000111 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1160717000112 Part of AAA domain; Region: AAA_19; pfam13245 1160717000113 Family description; Region: UvrD_C_2; pfam13538 1160717000114 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1160717000115 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1160717000116 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1160717000117 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1160717000118 ATP binding site [chemical binding]; other site 1160717000119 Mg++ binding site [ion binding]; other site 1160717000120 motif III; other site 1160717000121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717000122 nucleotide binding region [chemical binding]; other site 1160717000123 ATP-binding site [chemical binding]; other site 1160717000124 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1160717000125 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1160717000126 catalytic residues [active] 1160717000127 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1160717000128 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1160717000129 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1160717000130 RNA binding site [nucleotide binding]; other site 1160717000131 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1160717000132 multimer interface [polypeptide binding]; other site 1160717000133 Walker A motif; other site 1160717000134 ATP binding site [chemical binding]; other site 1160717000135 Walker B motif; other site 1160717000136 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1160717000137 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1160717000138 Mg++ binding site [ion binding]; other site 1160717000139 putative catalytic motif [active] 1160717000140 substrate binding site [chemical binding]; other site 1160717000141 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1160717000142 Chain length determinant protein; Region: Wzz; pfam02706 1160717000143 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1160717000144 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1160717000145 homodimer interface [polypeptide binding]; other site 1160717000146 active site 1160717000147 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1160717000148 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1160717000149 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1160717000150 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1160717000151 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1160717000152 NAD binding site [chemical binding]; other site 1160717000153 substrate binding site [chemical binding]; other site 1160717000154 homodimer interface [polypeptide binding]; other site 1160717000155 active site 1160717000156 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1160717000157 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717000158 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1160717000159 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1160717000160 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1160717000161 inhibitor-cofactor binding pocket; inhibition site 1160717000162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717000163 catalytic residue [active] 1160717000164 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1160717000165 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1160717000166 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1160717000167 putative common antigen polymerase; Provisional; Region: PRK02975 1160717000168 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1160717000169 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1160717000170 putative transport protein YifK; Provisional; Region: PRK10746 1160717000171 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1160717000172 HemY protein N-terminus; Region: HemY_N; pfam07219 1160717000173 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1160717000174 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1160717000175 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1160717000176 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1160717000177 active site 1160717000178 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1160717000179 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1160717000180 active site 1160717000181 domain interfaces; other site 1160717000182 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1160717000183 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1160717000184 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1160717000185 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1160717000186 putative iron binding site [ion binding]; other site 1160717000187 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1160717000188 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1160717000189 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1160717000190 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1160717000191 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1160717000192 hypothetical protein; Provisional; Region: PRK10963 1160717000193 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1160717000194 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1160717000195 active site 1160717000196 Int/Topo IB signature motif; other site 1160717000197 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1160717000198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717000199 motif II; other site 1160717000200 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1160717000201 Part of AAA domain; Region: AAA_19; pfam13245 1160717000202 Family description; Region: UvrD_C_2; pfam13538 1160717000203 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1160717000204 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1160717000205 Cl binding site [ion binding]; other site 1160717000206 oligomer interface [polypeptide binding]; other site 1160717000207 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1160717000208 EamA-like transporter family; Region: EamA; cl17759 1160717000209 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1160717000210 CoenzymeA binding site [chemical binding]; other site 1160717000211 subunit interaction site [polypeptide binding]; other site 1160717000212 PHB binding site; other site 1160717000213 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1160717000214 dimerization interface [polypeptide binding]; other site 1160717000215 substrate binding site [chemical binding]; other site 1160717000216 active site 1160717000217 calcium binding site [ion binding]; other site 1160717000218 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1160717000219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717000220 ATP binding site [chemical binding]; other site 1160717000221 putative Mg++ binding site [ion binding]; other site 1160717000222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717000223 nucleotide binding region [chemical binding]; other site 1160717000224 ATP-binding site [chemical binding]; other site 1160717000225 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1160717000226 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1160717000227 threonine efflux system; Provisional; Region: PRK10229 1160717000228 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1160717000229 lysophospholipase L2; Provisional; Region: PRK10749 1160717000230 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1160717000231 putative hydrolase; Provisional; Region: PRK10976 1160717000232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717000233 active site 1160717000234 motif I; other site 1160717000235 motif II; other site 1160717000236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717000237 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1160717000238 EamA-like transporter family; Region: EamA; pfam00892 1160717000239 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1160717000240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717000241 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1160717000242 putative dimerization interface [polypeptide binding]; other site 1160717000243 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1160717000244 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1160717000245 THF binding site; other site 1160717000246 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1160717000247 substrate binding site [chemical binding]; other site 1160717000248 THF binding site; other site 1160717000249 zinc-binding site [ion binding]; other site 1160717000250 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1160717000251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717000252 FeS/SAM binding site; other site 1160717000253 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1160717000254 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1160717000255 uridine phosphorylase; Provisional; Region: PRK11178 1160717000256 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1160717000257 DNA recombination protein RmuC; Provisional; Region: PRK10361 1160717000258 RmuC family; Region: RmuC; pfam02646 1160717000259 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1160717000260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717000261 S-adenosylmethionine binding site [chemical binding]; other site 1160717000262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1160717000263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1160717000264 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1160717000265 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1160717000266 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1160717000267 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1160717000268 sec-independent translocase; Provisional; Region: PRK01770 1160717000269 sec-independent translocase; Provisional; Region: tatB; PRK00404 1160717000270 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1160717000271 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1160717000272 active site 1160717000273 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1160717000274 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1160717000275 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1160717000276 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1160717000277 FMN reductase; Validated; Region: fre; PRK08051 1160717000278 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1160717000279 FAD binding pocket [chemical binding]; other site 1160717000280 FAD binding motif [chemical binding]; other site 1160717000281 phosphate binding motif [ion binding]; other site 1160717000282 beta-alpha-beta structure motif; other site 1160717000283 NAD binding pocket [chemical binding]; other site 1160717000284 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1160717000285 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1160717000286 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1160717000287 dimer interface [polypeptide binding]; other site 1160717000288 active site 1160717000289 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1160717000290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1160717000291 substrate binding site [chemical binding]; other site 1160717000292 oxyanion hole (OAH) forming residues; other site 1160717000293 trimer interface [polypeptide binding]; other site 1160717000294 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1160717000295 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1160717000296 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1160717000297 proline dipeptidase; Provisional; Region: PRK13607 1160717000298 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1160717000299 active site 1160717000300 hypothetical protein; Provisional; Region: PRK11568 1160717000301 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1160717000302 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1160717000303 potassium transporter; Provisional; Region: PRK10750 1160717000304 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1160717000305 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1160717000306 PK-G12rRNA; SU5_nc4 1160717000307 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1160717000308 Walker A motif; other site 1160717000309 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1160717000310 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1160717000311 GTP binding site; other site 1160717000312 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1160717000313 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1160717000314 serine/threonine protein kinase; Provisional; Region: PRK11768 1160717000315 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1160717000316 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1160717000317 catalytic residues [active] 1160717000318 hinge region; other site 1160717000319 alpha helical domain; other site 1160717000320 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1160717000321 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1160717000322 putative acyl-acceptor binding pocket; other site 1160717000323 DNA polymerase I; Provisional; Region: PRK05755 1160717000324 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1160717000325 active site 1160717000326 metal binding site 1 [ion binding]; metal-binding site 1160717000327 putative 5' ssDNA interaction site; other site 1160717000328 metal binding site 3; metal-binding site 1160717000329 metal binding site 2 [ion binding]; metal-binding site 1160717000330 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1160717000331 putative DNA binding site [nucleotide binding]; other site 1160717000332 putative metal binding site [ion binding]; other site 1160717000333 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1160717000334 active site 1160717000335 catalytic site [active] 1160717000336 substrate binding site [chemical binding]; other site 1160717000337 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1160717000338 active site 1160717000339 DNA binding site [nucleotide binding] 1160717000340 catalytic site [active] 1160717000341 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1160717000342 G1 box; other site 1160717000343 GTP/Mg2+ binding site [chemical binding]; other site 1160717000344 Switch I region; other site 1160717000345 G2 box; other site 1160717000346 G3 box; other site 1160717000347 Switch II region; other site 1160717000348 G4 box; other site 1160717000349 G5 box; other site 1160717000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1160717000351 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1160717000352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717000353 FeS/SAM binding site; other site 1160717000354 HemN C-terminal domain; Region: HemN_C; pfam06969 1160717000355 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1160717000356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717000357 active site 1160717000358 phosphorylation site [posttranslational modification] 1160717000359 intermolecular recognition site; other site 1160717000360 dimerization interface [polypeptide binding]; other site 1160717000361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717000362 Walker A motif; other site 1160717000363 ATP binding site [chemical binding]; other site 1160717000364 Walker B motif; other site 1160717000365 arginine finger; other site 1160717000366 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1160717000367 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1160717000368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717000369 putative active site [active] 1160717000370 heme pocket [chemical binding]; other site 1160717000371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717000372 dimer interface [polypeptide binding]; other site 1160717000373 phosphorylation site [posttranslational modification] 1160717000374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717000375 ATP binding site [chemical binding]; other site 1160717000376 Mg2+ binding site [ion binding]; other site 1160717000377 G-X-G motif; other site 1160717000378 glutamine synthetase; Provisional; Region: glnA; PRK09469 1160717000379 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1160717000380 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1160717000381 GTP-binding protein; Provisional; Region: PRK10218 1160717000382 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1160717000383 G1 box; other site 1160717000384 putative GEF interaction site [polypeptide binding]; other site 1160717000385 GTP/Mg2+ binding site [chemical binding]; other site 1160717000386 Switch I region; other site 1160717000387 G2 box; other site 1160717000388 G3 box; other site 1160717000389 Switch II region; other site 1160717000390 G4 box; other site 1160717000391 G5 box; other site 1160717000392 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1160717000393 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1160717000394 outer membrane porin L; Provisional; Region: ompL; PRK09980 1160717000395 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1160717000396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717000397 putative substrate translocation pore; other site 1160717000398 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1160717000399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717000400 putative substrate translocation pore; other site 1160717000401 alpha-glucosidase; Provisional; Region: PRK10426 1160717000402 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1160717000403 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1160717000404 putative active site [active] 1160717000405 putative catalytic site [active] 1160717000406 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1160717000407 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1160717000408 active site 1160717000409 catalytic residues [active] 1160717000410 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1160717000411 dimerization interface [polypeptide binding]; other site 1160717000412 putative active cleft [active] 1160717000413 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1160717000414 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1160717000415 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1160717000416 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717000417 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1160717000418 substrate binding site [chemical binding]; other site 1160717000419 ATP binding site [chemical binding]; other site 1160717000420 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717000421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717000422 putative DNA binding site [nucleotide binding]; other site 1160717000423 putative Zn2+ binding site [ion binding]; other site 1160717000424 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717000425 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1160717000426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717000427 motif II; other site 1160717000428 hypothetical protein; Reviewed; Region: PRK01637 1160717000429 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1160717000430 putative active site [active] 1160717000431 dimerization interface [polypeptide binding]; other site 1160717000432 putative tRNAtyr binding site [nucleotide binding]; other site 1160717000433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717000434 Coenzyme A binding pocket [chemical binding]; other site 1160717000435 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1160717000436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717000437 non-specific DNA binding site [nucleotide binding]; other site 1160717000438 salt bridge; other site 1160717000439 sequence-specific DNA binding site [nucleotide binding]; other site 1160717000440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1160717000441 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1160717000442 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1160717000443 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1160717000444 Predicted transcriptional regulator [Transcription]; Region: COG2944 1160717000445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717000446 non-specific DNA binding site [nucleotide binding]; other site 1160717000447 salt bridge; other site 1160717000448 sequence-specific DNA binding site [nucleotide binding]; other site 1160717000449 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1160717000450 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1160717000451 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1160717000452 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1160717000453 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1160717000454 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1160717000455 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1160717000456 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1160717000457 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1160717000458 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1160717000459 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1160717000460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717000461 non-specific DNA binding site [nucleotide binding]; other site 1160717000462 salt bridge; other site 1160717000463 sequence-specific DNA binding site [nucleotide binding]; other site 1160717000464 Cupin domain; Region: Cupin_2; cl17218 1160717000465 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1160717000466 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1160717000467 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1160717000468 dimer interface [polypeptide binding]; other site 1160717000469 active site 1160717000470 metal binding site [ion binding]; metal-binding site 1160717000471 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1160717000472 intersubunit interface [polypeptide binding]; other site 1160717000473 active site 1160717000474 Zn2+ binding site [ion binding]; other site 1160717000475 L-rhamnose isomerase; Provisional; Region: PRK01076 1160717000476 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1160717000477 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1160717000478 N- and C-terminal domain interface [polypeptide binding]; other site 1160717000479 active site 1160717000480 putative catalytic site [active] 1160717000481 metal binding site [ion binding]; metal-binding site 1160717000482 ATP binding site [chemical binding]; other site 1160717000483 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1160717000484 carbohydrate binding site [chemical binding]; other site 1160717000485 transcriptional activator RhaS; Provisional; Region: PRK13503 1160717000486 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1160717000487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717000488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717000489 transcriptional activator RhaR; Provisional; Region: PRK13502 1160717000490 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1160717000491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717000492 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 1160717000493 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1160717000494 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1160717000495 DctM-like transporters; Region: DctM; pfam06808 1160717000496 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1160717000497 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1160717000498 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1160717000499 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1160717000500 superoxide dismutase; Provisional; Region: PRK10925 1160717000501 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1160717000502 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1160717000503 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1160717000504 MOSC domain; Region: MOSC; pfam03473 1160717000505 3-alpha domain; Region: 3-alpha; pfam03475 1160717000506 SnoaL-like domain; Region: SnoaL_2; pfam12680 1160717000507 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1160717000508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717000509 dimerization interface [polypeptide binding]; other site 1160717000510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717000511 dimer interface [polypeptide binding]; other site 1160717000512 phosphorylation site [posttranslational modification] 1160717000513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717000514 ATP binding site [chemical binding]; other site 1160717000515 Mg2+ binding site [ion binding]; other site 1160717000516 G-X-G motif; other site 1160717000517 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1160717000518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717000519 active site 1160717000520 intermolecular recognition site; other site 1160717000521 dimerization interface [polypeptide binding]; other site 1160717000522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717000523 DNA binding site [nucleotide binding] 1160717000524 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1160717000525 dimer interface [polypeptide binding]; other site 1160717000526 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1160717000527 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1160717000528 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1160717000529 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1160717000530 active site 1160717000531 ADP/pyrophosphate binding site [chemical binding]; other site 1160717000532 dimerization interface [polypeptide binding]; other site 1160717000533 allosteric effector site; other site 1160717000534 fructose-1,6-bisphosphate binding site; other site 1160717000535 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1160717000536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717000537 substrate binding pocket [chemical binding]; other site 1160717000538 membrane-bound complex binding site; other site 1160717000539 hinge residues; other site 1160717000540 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1160717000541 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1160717000542 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1160717000543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717000544 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1160717000545 putative substrate binding site [chemical binding]; other site 1160717000546 putative ATP binding site [chemical binding]; other site 1160717000547 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1160717000548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1160717000549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717000550 DNA-binding site [nucleotide binding]; DNA binding site 1160717000551 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 1160717000552 UTRA domain; Region: UTRA; pfam07702 1160717000553 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1160717000554 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1160717000555 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1160717000556 putative N- and C-terminal domain interface [polypeptide binding]; other site 1160717000557 putative active site [active] 1160717000558 putative MgATP binding site [chemical binding]; other site 1160717000559 catalytic site [active] 1160717000560 metal binding site [ion binding]; metal-binding site 1160717000561 putative carbohydrate binding site [chemical binding]; other site 1160717000562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1160717000563 transcriptional regulator LsrR; Provisional; Region: PRK15418 1160717000564 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1160717000565 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1160717000566 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1160717000567 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1160717000568 Walker A/P-loop; other site 1160717000569 ATP binding site [chemical binding]; other site 1160717000570 Q-loop/lid; other site 1160717000571 ABC transporter signature motif; other site 1160717000572 Walker B; other site 1160717000573 D-loop; other site 1160717000574 H-loop/switch region; other site 1160717000575 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1160717000576 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1160717000577 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1160717000578 TM-ABC transporter signature motif; other site 1160717000579 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1160717000580 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1160717000581 TM-ABC transporter signature motif; other site 1160717000582 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1160717000583 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1160717000584 ligand binding site [chemical binding]; other site 1160717000585 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1160717000586 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1160717000587 putative active site; other site 1160717000588 catalytic residue [active] 1160717000589 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1160717000590 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1160717000591 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1160717000592 substrate binding site [chemical binding]; other site 1160717000593 hexamer interface [polypeptide binding]; other site 1160717000594 metal binding site [ion binding]; metal-binding site 1160717000595 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1160717000596 triosephosphate isomerase; Provisional; Region: PRK14567 1160717000597 substrate binding site [chemical binding]; other site 1160717000598 dimer interface [polypeptide binding]; other site 1160717000599 catalytic triad [active] 1160717000600 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1160717000601 Predicted membrane protein [Function unknown]; Region: COG3152 1160717000602 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1160717000603 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1160717000604 FAD binding pocket [chemical binding]; other site 1160717000605 FAD binding motif [chemical binding]; other site 1160717000606 phosphate binding motif [ion binding]; other site 1160717000607 beta-alpha-beta structure motif; other site 1160717000608 NAD binding pocket [chemical binding]; other site 1160717000609 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1160717000610 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1160717000611 putative active site [active] 1160717000612 glycerol kinase; Provisional; Region: glpK; PRK00047 1160717000613 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1160717000614 N- and C-terminal domain interface [polypeptide binding]; other site 1160717000615 active site 1160717000616 MgATP binding site [chemical binding]; other site 1160717000617 catalytic site [active] 1160717000618 metal binding site [ion binding]; metal-binding site 1160717000619 glycerol binding site [chemical binding]; other site 1160717000620 homotetramer interface [polypeptide binding]; other site 1160717000621 homodimer interface [polypeptide binding]; other site 1160717000622 FBP binding site [chemical binding]; other site 1160717000623 protein IIAGlc interface [polypeptide binding]; other site 1160717000624 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1160717000625 amphipathic channel; other site 1160717000626 Asn-Pro-Ala signature motifs; other site 1160717000627 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1160717000628 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1160717000629 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1160717000630 UbiA prenyltransferase family; Region: UbiA; pfam01040 1160717000631 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1160717000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717000633 Walker A motif; other site 1160717000634 ATP binding site [chemical binding]; other site 1160717000635 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1160717000636 Walker B motif; other site 1160717000637 arginine finger; other site 1160717000638 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1160717000639 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 1160717000640 essential cell division protein FtsN; Provisional; Region: PRK10927 1160717000641 cell division protein FtsN; Provisional; Region: PRK12757 1160717000642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717000643 DNA binding site [nucleotide binding] 1160717000644 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1160717000645 domain linker motif; other site 1160717000646 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1160717000647 dimerization interface [polypeptide binding]; other site 1160717000648 ligand binding site [chemical binding]; other site 1160717000649 primosome assembly protein PriA; Validated; Region: PRK05580 1160717000650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717000651 ATP binding site [chemical binding]; other site 1160717000652 putative Mg++ binding site [ion binding]; other site 1160717000653 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1160717000654 ATP-binding site [chemical binding]; other site 1160717000655 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1160717000656 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1160717000657 dimerization interface [polypeptide binding]; other site 1160717000658 DNA binding site [nucleotide binding] 1160717000659 corepressor binding sites; other site 1160717000660 cystathionine gamma-synthase; Provisional; Region: PRK08045 1160717000661 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1160717000662 homodimer interface [polypeptide binding]; other site 1160717000663 substrate-cofactor binding pocket; other site 1160717000664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717000665 catalytic residue [active] 1160717000666 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1160717000667 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1160717000668 putative catalytic residues [active] 1160717000669 putative nucleotide binding site [chemical binding]; other site 1160717000670 putative aspartate binding site [chemical binding]; other site 1160717000671 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1160717000672 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1160717000673 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1160717000674 mechanosensitive channel MscS; Provisional; Region: PRK10334 1160717000675 Conserved TM helix; Region: TM_helix; pfam05552 1160717000676 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717000677 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1160717000678 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1160717000679 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1160717000680 active site 1160717000681 metal binding site [ion binding]; metal-binding site 1160717000682 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1160717000683 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1160717000684 FAD binding site [chemical binding]; other site 1160717000685 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1160717000686 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1160717000687 heme binding site [chemical binding]; other site 1160717000688 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1160717000689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1160717000690 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1160717000691 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1160717000692 dimer interface [polypeptide binding]; other site 1160717000693 active site 1160717000694 metal binding site [ion binding]; metal-binding site 1160717000695 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1160717000696 active site 1160717000697 intersubunit interactions; other site 1160717000698 catalytic residue [active] 1160717000699 hypothetical protein; Provisional; Region: PRK10649 1160717000700 Sulfatase; Region: Sulfatase; pfam00884 1160717000701 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1160717000702 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1160717000703 acetylornithine deacetylase; Provisional; Region: PRK05111 1160717000704 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1160717000705 metal binding site [ion binding]; metal-binding site 1160717000706 putative dimer interface [polypeptide binding]; other site 1160717000707 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1160717000708 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1160717000709 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1160717000710 nucleotide binding site [chemical binding]; other site 1160717000711 N-acetyl-L-glutamate binding site [chemical binding]; other site 1160717000712 argininosuccinate lyase; Provisional; Region: PRK04833 1160717000713 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1160717000714 active sites [active] 1160717000715 tetramer interface [polypeptide binding]; other site 1160717000716 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1160717000717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717000718 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1160717000719 dimerization interface [polypeptide binding]; other site 1160717000720 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1160717000721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717000722 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1160717000723 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1160717000724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717000725 hypothetical protein; Provisional; Region: PRK11056 1160717000726 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1160717000727 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1160717000728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717000729 S-adenosylmethionine binding site [chemical binding]; other site 1160717000730 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1160717000731 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1160717000732 N-terminal plug; other site 1160717000733 ligand-binding site [chemical binding]; other site 1160717000734 glutamate racemase; Provisional; Region: PRK00865 1160717000735 PK-G12rRNA; SU5_nc12 1160717000736 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1160717000737 FAD binding domain; Region: FAD_binding_4; pfam01565 1160717000738 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1160717000739 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1160717000740 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1160717000741 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1160717000742 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1160717000743 pantothenate kinase; Provisional; Region: PRK05439 1160717000744 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1160717000745 ATP-binding site [chemical binding]; other site 1160717000746 CoA-binding site [chemical binding]; other site 1160717000747 Mg2+-binding site [ion binding]; other site 1160717000748 elongation factor Tu; Reviewed; Region: PRK00049 1160717000749 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1160717000750 G1 box; other site 1160717000751 GEF interaction site [polypeptide binding]; other site 1160717000752 GTP/Mg2+ binding site [chemical binding]; other site 1160717000753 Switch I region; other site 1160717000754 G2 box; other site 1160717000755 G3 box; other site 1160717000756 Switch II region; other site 1160717000757 G4 box; other site 1160717000758 G5 box; other site 1160717000759 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1160717000760 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1160717000761 Antibiotic Binding Site [chemical binding]; other site 1160717000762 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1160717000763 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1160717000764 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1160717000765 putative homodimer interface [polypeptide binding]; other site 1160717000766 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1160717000767 heterodimer interface [polypeptide binding]; other site 1160717000768 homodimer interface [polypeptide binding]; other site 1160717000769 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1160717000770 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1160717000771 23S rRNA interface [nucleotide binding]; other site 1160717000772 L7/L12 interface [polypeptide binding]; other site 1160717000773 putative thiostrepton binding site; other site 1160717000774 L25 interface [polypeptide binding]; other site 1160717000775 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1160717000776 mRNA/rRNA interface [nucleotide binding]; other site 1160717000777 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1160717000778 23S rRNA interface [nucleotide binding]; other site 1160717000779 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1160717000780 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1160717000781 core dimer interface [polypeptide binding]; other site 1160717000782 peripheral dimer interface [polypeptide binding]; other site 1160717000783 L10 interface [polypeptide binding]; other site 1160717000784 L11 interface [polypeptide binding]; other site 1160717000785 putative EF-Tu interaction site [polypeptide binding]; other site 1160717000786 putative EF-G interaction site [polypeptide binding]; other site 1160717000787 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1160717000788 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1160717000789 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1160717000790 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1160717000791 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1160717000792 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1160717000793 RPB3 interaction site [polypeptide binding]; other site 1160717000794 RPB1 interaction site [polypeptide binding]; other site 1160717000795 RPB11 interaction site [polypeptide binding]; other site 1160717000796 RPB10 interaction site [polypeptide binding]; other site 1160717000797 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1160717000798 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1160717000799 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1160717000800 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1160717000801 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1160717000802 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1160717000803 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1160717000804 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1160717000805 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1160717000806 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1160717000807 DNA binding site [nucleotide binding] 1160717000808 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1160717000809 Integrase core domain; Region: rve_3; cl15866 1160717000810 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1160717000811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717000812 FeS/SAM binding site; other site 1160717000813 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1160717000814 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1160717000815 ThiS interaction site; other site 1160717000816 putative active site [active] 1160717000817 tetramer interface [polypeptide binding]; other site 1160717000818 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1160717000819 thiS-thiF/thiG interaction site; other site 1160717000820 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1160717000821 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1160717000822 ATP binding site [chemical binding]; other site 1160717000823 substrate interface [chemical binding]; other site 1160717000824 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1160717000825 thiamine phosphate binding site [chemical binding]; other site 1160717000826 active site 1160717000827 pyrophosphate binding site [ion binding]; other site 1160717000828 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1160717000829 ThiC-associated domain; Region: ThiC-associated; pfam13667 1160717000830 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1160717000831 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1160717000832 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1160717000833 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1160717000834 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1160717000835 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1160717000836 putative NADH binding site [chemical binding]; other site 1160717000837 putative active site [active] 1160717000838 nudix motif; other site 1160717000839 putative metal binding site [ion binding]; other site 1160717000840 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1160717000841 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1160717000842 substrate binding site [chemical binding]; other site 1160717000843 active site 1160717000844 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1160717000845 Active_site [active] 1160717000846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1160717000847 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1160717000848 IHF dimer interface [polypeptide binding]; other site 1160717000849 IHF - DNA interface [nucleotide binding]; other site 1160717000850 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1160717000851 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1160717000852 dimer interface [polypeptide binding]; other site 1160717000853 sensor protein ZraS; Provisional; Region: PRK10364 1160717000854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717000855 dimer interface [polypeptide binding]; other site 1160717000856 phosphorylation site [posttranslational modification] 1160717000857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717000858 ATP binding site [chemical binding]; other site 1160717000859 Mg2+ binding site [ion binding]; other site 1160717000860 G-X-G motif; other site 1160717000861 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1160717000862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717000863 active site 1160717000864 phosphorylation site [posttranslational modification] 1160717000865 intermolecular recognition site; other site 1160717000866 dimerization interface [polypeptide binding]; other site 1160717000867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717000868 Walker A motif; other site 1160717000869 ATP binding site [chemical binding]; other site 1160717000870 Walker B motif; other site 1160717000871 arginine finger; other site 1160717000872 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1160717000873 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1160717000874 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1160717000875 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1160717000876 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1160717000877 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1160717000878 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1160717000879 purine monophosphate binding site [chemical binding]; other site 1160717000880 dimer interface [polypeptide binding]; other site 1160717000881 putative catalytic residues [active] 1160717000882 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1160717000883 PK-G12rRNA; SU5_nc15 1160717000884 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1160717000885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717000886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1160717000887 Coenzyme A binding pocket [chemical binding]; other site 1160717000888 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1160717000889 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1160717000890 proposed active site lysine [active] 1160717000891 conserved cys residue [active] 1160717000892 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1160717000893 malate synthase A; Region: malate_syn_A; TIGR01344 1160717000894 active site 1160717000895 isocitrate lyase; Provisional; Region: PRK15063 1160717000896 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1160717000897 tetramer interface [polypeptide binding]; other site 1160717000898 active site 1160717000899 Mg2+/Mn2+ binding site [ion binding]; other site 1160717000900 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1160717000901 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1160717000902 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1160717000903 transcriptional repressor IclR; Provisional; Region: PRK11569 1160717000904 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1160717000905 Bacterial transcriptional regulator; Region: IclR; pfam01614 1160717000906 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1160717000907 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1160717000908 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1160717000909 substrate binding pocket [chemical binding]; other site 1160717000910 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1160717000911 B12 binding site [chemical binding]; other site 1160717000912 cobalt ligand [ion binding]; other site 1160717000913 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1160717000914 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1160717000915 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1160717000916 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1160717000917 active site pocket [active] 1160717000918 oxyanion hole [active] 1160717000919 catalytic triad [active] 1160717000920 active site nucleophile [active] 1160717000921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1160717000922 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1160717000923 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717000924 RNA binding surface [nucleotide binding]; other site 1160717000925 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1160717000926 probable active site [active] 1160717000927 hypothetical protein; Provisional; Region: PRK10515 1160717000928 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1160717000929 Sodium Bile acid symporter family; Region: SBF; pfam01758 1160717000930 putative phage 1160717000931 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1160717000932 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1160717000933 trimer interface [polypeptide binding]; other site 1160717000934 active site 1160717000935 substrate binding site [chemical binding]; other site 1160717000936 CoA binding site [chemical binding]; other site 1160717000937 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1160717000938 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1160717000939 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1160717000940 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1160717000941 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1160717000942 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 1160717000943 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1160717000944 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1160717000945 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1160717000946 Ligand binding site; other site 1160717000947 Putative Catalytic site; other site 1160717000948 DXD motif; other site 1160717000949 Predicted membrane protein [Function unknown]; Region: COG2246 1160717000950 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1160717000951 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1160717000952 Phage protein D [General function prediction only]; Region: COG3500 1160717000953 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1160717000954 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1160717000955 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1160717000956 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1160717000957 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1160717000958 Phage tail tube protein FII [General function prediction only]; Region: COG3498 1160717000959 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1160717000960 Gp37 protein; Region: Gp37; pfam09646 1160717000961 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1160717000962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717000963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717000964 catalytic residue [active] 1160717000965 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1160717000966 Mor transcription activator family; Region: Mor; pfam08765 1160717000967 aspartate kinase III; Validated; Region: PRK09084 1160717000968 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1160717000969 nucleotide binding site [chemical binding]; other site 1160717000970 substrate binding site [chemical binding]; other site 1160717000971 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1160717000972 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1160717000973 dimer interface [polypeptide binding]; other site 1160717000974 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1160717000975 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1160717000976 active site 1160717000977 dimer interface [polypeptide binding]; other site 1160717000978 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1160717000979 dimer interface [polypeptide binding]; other site 1160717000980 active site 1160717000981 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 1160717000982 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1160717000983 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1160717000984 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1160717000985 Predicted membrane protein [Function unknown]; Region: COG3223 1160717000986 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1160717000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717000988 dimer interface [polypeptide binding]; other site 1160717000989 conserved gate region; other site 1160717000990 putative PBP binding loops; other site 1160717000991 ABC-ATPase subunit interface; other site 1160717000992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717000993 dimer interface [polypeptide binding]; other site 1160717000994 conserved gate region; other site 1160717000995 putative PBP binding loops; other site 1160717000996 ABC-ATPase subunit interface; other site 1160717000997 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1160717000998 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1160717000999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1160717001000 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1160717001001 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1160717001002 Walker A/P-loop; other site 1160717001003 ATP binding site [chemical binding]; other site 1160717001004 Q-loop/lid; other site 1160717001005 ABC transporter signature motif; other site 1160717001006 Walker B; other site 1160717001007 D-loop; other site 1160717001008 H-loop/switch region; other site 1160717001009 TOBE domain; Region: TOBE_2; pfam08402 1160717001010 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1160717001011 trimer interface; other site 1160717001012 sugar binding site [chemical binding]; other site 1160717001013 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1160717001014 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1160717001015 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1160717001016 UbiA prenyltransferase family; Region: UbiA; pfam01040 1160717001017 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1160717001018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1160717001019 putative acyl-acceptor binding pocket; other site 1160717001020 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1160717001021 LexA repressor; Validated; Region: PRK00215 1160717001022 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1160717001023 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1160717001024 Catalytic site [active] 1160717001025 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1160717001026 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1160717001027 hypothetical protein; Provisional; Region: PRK10428 1160717001028 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1160717001029 metal binding site 2 [ion binding]; metal-binding site 1160717001030 putative DNA binding helix; other site 1160717001031 metal binding site 1 [ion binding]; metal-binding site 1160717001032 dimer interface [polypeptide binding]; other site 1160717001033 structural Zn2+ binding site [ion binding]; other site 1160717001034 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1160717001035 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1160717001036 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1160717001037 FMN binding site [chemical binding]; other site 1160717001038 active site 1160717001039 catalytic residues [active] 1160717001040 substrate binding site [chemical binding]; other site 1160717001041 phage shock protein G; Reviewed; Region: pspG; PRK09459 1160717001042 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1160717001043 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1160717001044 NADP binding site [chemical binding]; other site 1160717001045 dimer interface [polypeptide binding]; other site 1160717001046 replicative DNA helicase; Provisional; Region: PRK08006 1160717001047 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1160717001048 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1160717001049 Walker A motif; other site 1160717001050 ATP binding site [chemical binding]; other site 1160717001051 Walker B motif; other site 1160717001052 DNA binding loops [nucleotide binding] 1160717001053 alanine racemase; Reviewed; Region: alr; PRK00053 1160717001054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1160717001055 active site 1160717001056 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717001057 substrate binding site [chemical binding]; other site 1160717001058 catalytic residues [active] 1160717001059 dimer interface [polypeptide binding]; other site 1160717001060 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1160717001061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717001062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717001063 homodimer interface [polypeptide binding]; other site 1160717001064 catalytic residue [active] 1160717001065 genomic island 1160717001066 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1160717001067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717001068 active site 1160717001069 motif I; other site 1160717001070 motif II; other site 1160717001071 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1160717001072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1160717001073 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1160717001074 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1160717001075 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1160717001076 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1160717001077 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1160717001078 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1160717001079 dimer interface [polypeptide binding]; other site 1160717001080 ssDNA binding site [nucleotide binding]; other site 1160717001081 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1160717001082 hypothetical protein; Validated; Region: PRK09039 1160717001083 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1160717001084 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1160717001085 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1160717001086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717001087 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717001088 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717001089 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001090 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001091 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001092 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001093 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001094 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001095 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717001096 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001097 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001098 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001099 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001100 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717001101 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001102 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001103 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717001104 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001105 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001106 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001107 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001108 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717001109 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001110 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001111 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001112 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001113 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001114 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001115 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1160717001116 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001118 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001119 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001120 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001121 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001122 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717001123 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001124 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 1160717001125 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001126 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001127 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717001128 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1160717001129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717001130 Walker A/P-loop; other site 1160717001131 ATP binding site [chemical binding]; other site 1160717001132 Q-loop/lid; other site 1160717001133 ABC transporter signature motif; other site 1160717001134 Walker B; other site 1160717001135 D-loop; other site 1160717001136 H-loop/switch region; other site 1160717001137 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1160717001138 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1160717001139 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717001140 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1160717001141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717001142 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1160717001143 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1160717001144 DNA binding residues [nucleotide binding] 1160717001145 dimer interface [polypeptide binding]; other site 1160717001146 [2Fe-2S] cluster binding site [ion binding]; other site 1160717001147 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1160717001148 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1160717001149 putative C-terminal domain interface [polypeptide binding]; other site 1160717001150 putative GSH binding site (G-site) [chemical binding]; other site 1160717001151 putative dimer interface [polypeptide binding]; other site 1160717001152 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1160717001153 putative N-terminal domain interface [polypeptide binding]; other site 1160717001154 putative dimer interface [polypeptide binding]; other site 1160717001155 putative substrate binding pocket (H-site) [chemical binding]; other site 1160717001156 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1160717001157 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1160717001158 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1160717001159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717001160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717001161 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1160717001162 putative dimerization interface [polypeptide binding]; other site 1160717001163 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1160717001164 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1160717001165 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1160717001166 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1160717001167 Na binding site [ion binding]; other site 1160717001168 Predicted membrane protein [Function unknown]; Region: COG3162 1160717001169 acetyl-CoA synthetase; Provisional; Region: PRK00174 1160717001170 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1160717001171 active site 1160717001172 CoA binding site [chemical binding]; other site 1160717001173 acyl-activating enzyme (AAE) consensus motif; other site 1160717001174 AMP binding site [chemical binding]; other site 1160717001175 acetate binding site [chemical binding]; other site 1160717001176 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1160717001177 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1160717001178 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1160717001179 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1160717001180 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1160717001181 heme lyase subunit NrfE; Provisional; Region: PRK10369 1160717001182 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1160717001183 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1160717001184 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1160717001185 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1160717001186 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717001187 Sel1-like repeats; Region: SEL1; smart00671 1160717001188 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717001189 molybdopterin cofactor binding site; other site 1160717001190 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1160717001191 molybdopterin cofactor binding site; other site 1160717001192 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717001193 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1160717001194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717001195 Coenzyme A binding pocket [chemical binding]; other site 1160717001196 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1160717001197 dimer interface [polypeptide binding]; other site 1160717001198 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1160717001199 hypothetical protein; Provisional; Region: PRK10220 1160717001200 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1160717001201 PhnA protein; Region: PhnA; pfam03831 1160717001202 proline/glycine betaine transporter; Provisional; Region: PRK10642 1160717001203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717001204 putative substrate translocation pore; other site 1160717001205 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1160717001206 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1160717001207 HAMP domain; Region: HAMP; pfam00672 1160717001208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717001209 dimer interface [polypeptide binding]; other site 1160717001210 phosphorylation site [posttranslational modification] 1160717001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717001212 ATP binding site [chemical binding]; other site 1160717001213 Mg2+ binding site [ion binding]; other site 1160717001214 G-X-G motif; other site 1160717001215 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1160717001216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717001217 active site 1160717001218 phosphorylation site [posttranslational modification] 1160717001219 intermolecular recognition site; other site 1160717001220 dimerization interface [polypeptide binding]; other site 1160717001221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717001222 DNA binding site [nucleotide binding] 1160717001223 putative metal dependent hydrolase; Provisional; Region: PRK11598 1160717001224 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1160717001225 Sulfatase; Region: Sulfatase; pfam00884 1160717001226 arginine:agmatin antiporter; Provisional; Region: PRK10644 1160717001227 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1160717001228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717001229 arginine decarboxylase; Provisional; Region: PRK15029 1160717001230 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1160717001231 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1160717001232 homodimer interface [polypeptide binding]; other site 1160717001233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717001234 catalytic residue [active] 1160717001235 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1160717001236 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1160717001237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717001238 alpha-galactosidase; Provisional; Region: PRK15076 1160717001239 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1160717001240 NAD binding site [chemical binding]; other site 1160717001241 sugar binding site [chemical binding]; other site 1160717001242 divalent metal binding site [ion binding]; other site 1160717001243 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1160717001244 dimer interface [polypeptide binding]; other site 1160717001245 melibiose:sodium symporter; Provisional; Region: PRK10429 1160717001246 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1160717001247 fumarate hydratase; Provisional; Region: PRK15389 1160717001248 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1160717001249 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1160717001250 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1160717001251 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1160717001252 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1160717001253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717001254 active site 1160717001255 phosphorylation site [posttranslational modification] 1160717001256 intermolecular recognition site; other site 1160717001257 dimerization interface [polypeptide binding]; other site 1160717001258 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1160717001259 PAS domain; Region: PAS; smart00091 1160717001260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717001261 ATP binding site [chemical binding]; other site 1160717001262 Mg2+ binding site [ion binding]; other site 1160717001263 G-X-G motif; other site 1160717001264 genomic island 1160717001265 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1160717001266 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1160717001267 putative [Fe4-S4] binding site [ion binding]; other site 1160717001268 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717001269 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1160717001270 putative molybdopterin cofactor binding site; other site 1160717001271 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1160717001272 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1160717001273 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1160717001274 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1160717001275 SdiA-regulated; Region: SdiA-regulated; pfam06977 1160717001276 SdiA-regulated; Region: SdiA-regulated; cd09971 1160717001277 putative active site [active] 1160717001278 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1160717001279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717001280 DNA binding residues [nucleotide binding] 1160717001281 dimerization interface [polypeptide binding]; other site 1160717001282 AraC family transcriptional regulator; Provisional; Region: PRK15186 1160717001283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717001284 Integrase core domain; Region: rve; pfam00665 1160717001285 Integrase core domain; Region: rve_2; pfam13333 1160717001286 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1160717001287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1160717001288 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1160717001289 active site 1160717001290 putative transcriptional regulator; Provisional; Region: PRK11640 1160717001291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717001292 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1160717001293 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1160717001294 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1160717001295 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1160717001296 DsbD alpha interface [polypeptide binding]; other site 1160717001297 catalytic residues [active] 1160717001298 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1160717001299 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1160717001300 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1160717001301 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1160717001302 Aspartase; Region: Aspartase; cd01357 1160717001303 active sites [active] 1160717001304 tetramer interface [polypeptide binding]; other site 1160717001305 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1160717001306 putative transporter; Provisional; Region: PRK11021 1160717001307 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1160717001308 oligomerisation interface [polypeptide binding]; other site 1160717001309 mobile loop; other site 1160717001310 roof hairpin; other site 1160717001311 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1160717001312 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1160717001313 ring oligomerisation interface [polypeptide binding]; other site 1160717001314 ATP/Mg binding site [chemical binding]; other site 1160717001315 stacking interactions; other site 1160717001316 hinge regions; other site 1160717001317 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1160717001318 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1160717001319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717001320 FeS/SAM binding site; other site 1160717001321 elongation factor P; Validated; Region: PRK00529 1160717001322 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1160717001323 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1160717001324 RNA binding site [nucleotide binding]; other site 1160717001325 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1160717001326 RNA binding site [nucleotide binding]; other site 1160717001327 Predicted small secreted protein [Function unknown]; Region: COG5510 1160717001328 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1160717001329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1160717001330 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717001331 DNA binding residues [nucleotide binding] 1160717001332 dimerization interface [polypeptide binding]; other site 1160717001333 multidrug efflux system protein; Provisional; Region: PRK11431 1160717001334 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1160717001335 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1160717001336 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1160717001337 Iron-sulfur protein interface; other site 1160717001338 proximal quinone binding site [chemical binding]; other site 1160717001339 C-subunit interface; other site 1160717001340 distal quinone binding site; other site 1160717001341 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1160717001342 D-subunit interface [polypeptide binding]; other site 1160717001343 Iron-sulfur protein interface; other site 1160717001344 proximal quinone binding site [chemical binding]; other site 1160717001345 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1160717001346 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1160717001347 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1160717001348 L-aspartate oxidase; Provisional; Region: PRK06175 1160717001349 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1160717001350 poxB regulator PoxA; Provisional; Region: PRK09350 1160717001351 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1160717001352 motif 1; other site 1160717001353 dimer interface [polypeptide binding]; other site 1160717001354 active site 1160717001355 motif 2; other site 1160717001356 motif 3; other site 1160717001357 inner membrane transporter YjeM; Provisional; Region: PRK15238 1160717001358 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1160717001359 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1160717001360 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717001361 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1160717001362 GTPase RsgA; Reviewed; Region: PRK12288 1160717001363 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1160717001364 RNA binding site [nucleotide binding]; other site 1160717001365 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1160717001366 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1160717001367 GTP/Mg2+ binding site [chemical binding]; other site 1160717001368 G4 box; other site 1160717001369 G5 box; other site 1160717001370 G1 box; other site 1160717001371 Switch I region; other site 1160717001372 G2 box; other site 1160717001373 G3 box; other site 1160717001374 Switch II region; other site 1160717001375 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1160717001376 catalytic site [active] 1160717001377 putative active site [active] 1160717001378 putative substrate binding site [chemical binding]; other site 1160717001379 dimer interface [polypeptide binding]; other site 1160717001380 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1160717001381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717001382 substrate binding pocket [chemical binding]; other site 1160717001383 membrane-bound complex binding site; other site 1160717001384 hinge residues; other site 1160717001385 epoxyqueuosine reductase; Region: TIGR00276 1160717001386 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1160717001387 putative carbohydrate kinase; Provisional; Region: PRK10565 1160717001388 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1160717001389 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1160717001390 putative substrate binding site [chemical binding]; other site 1160717001391 putative ATP binding site [chemical binding]; other site 1160717001392 ADP-binding protein; Provisional; Region: PRK10646 1160717001393 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1160717001394 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1160717001395 active site 1160717001396 metal binding site [ion binding]; metal-binding site 1160717001397 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1160717001398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717001399 ATP binding site [chemical binding]; other site 1160717001400 Mg2+ binding site [ion binding]; other site 1160717001401 G-X-G motif; other site 1160717001402 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1160717001403 ATP binding site [chemical binding]; other site 1160717001404 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1160717001405 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1160717001406 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1160717001407 bacterial Hfq-like; Region: Hfq; cd01716 1160717001408 hexamer interface [polypeptide binding]; other site 1160717001409 Sm1 motif; other site 1160717001410 RNA binding site [nucleotide binding]; other site 1160717001411 Sm2 motif; other site 1160717001412 GTPase HflX; Provisional; Region: PRK11058 1160717001413 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1160717001414 HflX GTPase family; Region: HflX; cd01878 1160717001415 G1 box; other site 1160717001416 GTP/Mg2+ binding site [chemical binding]; other site 1160717001417 Switch I region; other site 1160717001418 G2 box; other site 1160717001419 G3 box; other site 1160717001420 Switch II region; other site 1160717001421 G4 box; other site 1160717001422 G5 box; other site 1160717001423 FtsH protease regulator HflK; Provisional; Region: PRK10930 1160717001424 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1160717001425 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1160717001426 FtsH protease regulator HflC; Provisional; Region: PRK11029 1160717001427 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1160717001428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1160717001429 Predicted transcriptional regulator [Transcription]; Region: COG1959 1160717001430 transcriptional repressor NsrR; Provisional; Region: PRK11014 1160717001431 exoribonuclease R; Provisional; Region: PRK11642 1160717001432 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1160717001433 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1160717001434 RNB domain; Region: RNB; pfam00773 1160717001435 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1160717001436 RNA binding site [nucleotide binding]; other site 1160717001437 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1160717001438 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1160717001439 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1160717001440 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1160717001441 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1160717001442 Ion channel; Region: Ion_trans_2; pfam07885 1160717001443 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1160717001444 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1160717001445 Predicted membrane protein [Function unknown]; Region: COG3766 1160717001446 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1160717001447 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1160717001448 Predicted integral membrane protein [Function unknown]; Region: COG5463 1160717001449 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1160717001450 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1160717001451 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1160717001452 FAD binding site [chemical binding]; other site 1160717001453 substrate binding site [chemical binding]; other site 1160717001454 catalytic residues [active] 1160717001455 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717001456 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1160717001457 esterase; Provisional; Region: PRK10566 1160717001458 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1160717001459 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1160717001460 transcriptional repressor UlaR; Provisional; Region: PRK13509 1160717001461 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1160717001462 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717001463 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1160717001464 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1160717001465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1160717001466 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1160717001467 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1160717001468 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717001469 active site 1160717001470 phosphorylation site [posttranslational modification] 1160717001471 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1160717001472 active site 1160717001473 dimer interface [polypeptide binding]; other site 1160717001474 magnesium binding site [ion binding]; other site 1160717001475 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1160717001476 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1160717001477 AP (apurinic/apyrimidinic) site pocket; other site 1160717001478 DNA interaction; other site 1160717001479 Metal-binding active site; metal-binding site 1160717001480 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1160717001481 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1160717001482 intersubunit interface [polypeptide binding]; other site 1160717001483 active site 1160717001484 Zn2+ binding site [ion binding]; other site 1160717001485 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717001486 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1160717001487 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1160717001488 dimer interface [polypeptide binding]; other site 1160717001489 ssDNA binding site [nucleotide binding]; other site 1160717001490 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1160717001491 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1160717001492 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1160717001493 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1160717001494 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1160717001495 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1160717001496 EamA-like transporter family; Region: EamA; pfam00892 1160717001497 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1160717001498 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1160717001499 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1160717001500 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1160717001501 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1160717001502 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1160717001503 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1160717001504 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1160717001505 Hemerythrin-like domain; Region: Hr-like; cd12108 1160717001506 Fe binding site [ion binding]; other site 1160717001507 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1160717001508 EamA-like transporter family; Region: EamA; pfam00892 1160717001509 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1160717001510 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1160717001511 NADP binding site [chemical binding]; other site 1160717001512 Predicted transcriptional regulators [Transcription]; Region: COG1733 1160717001513 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1160717001514 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1160717001515 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1160717001516 active site 1160717001517 metal binding site [ion binding]; metal-binding site 1160717001518 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1160717001519 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1160717001520 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1160717001521 active site 1160717001522 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1160717001523 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1160717001524 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1160717001525 Domain of unknown function DUF21; Region: DUF21; pfam01595 1160717001526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1160717001527 Transporter associated domain; Region: CorC_HlyC; smart01091 1160717001528 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1160717001529 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1160717001530 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1160717001531 Surface antigen; Region: Bac_surface_Ag; pfam01103 1160717001532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1160717001533 Family of unknown function (DUF490); Region: DUF490; pfam04357 1160717001534 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1160717001535 dimerization interface [polypeptide binding]; other site 1160717001536 putative active site pocket [active] 1160717001537 putative catalytic residue [active] 1160717001538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717001539 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717001540 putative substrate translocation pore; other site 1160717001541 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1160717001542 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1160717001543 active site 1160717001544 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1160717001545 dimer interface [polypeptide binding]; other site 1160717001546 substrate binding site [chemical binding]; other site 1160717001547 metal binding sites [ion binding]; metal-binding site 1160717001548 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1160717001549 AMP binding site [chemical binding]; other site 1160717001550 metal binding site [ion binding]; metal-binding site 1160717001551 active site 1160717001552 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1160717001553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1160717001554 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1160717001555 hypothetical protein; Provisional; Region: PRK05255 1160717001556 peptidase PmbA; Provisional; Region: PRK11040 1160717001557 cytochrome b562; Provisional; Region: PRK15058 1160717001558 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1160717001559 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1160717001560 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1160717001561 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1160717001562 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1160717001563 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1160717001564 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1160717001565 active site 1160717001566 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1160717001567 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1160717001568 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1160717001569 HTH domain; Region: HTH_11; pfam08279 1160717001570 Mga helix-turn-helix domain; Region: Mga; pfam05043 1160717001571 PRD domain; Region: PRD; pfam00874 1160717001572 PRD domain; Region: PRD; pfam00874 1160717001573 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1160717001574 active site 1160717001575 P-loop; other site 1160717001576 phosphorylation site [posttranslational modification] 1160717001577 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717001578 active site 1160717001579 phosphorylation site [posttranslational modification] 1160717001580 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1160717001581 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1160717001582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717001583 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 1160717001584 FeS/SAM binding site; other site 1160717001585 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1160717001586 ATP cone domain; Region: ATP-cone; pfam03477 1160717001587 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1160717001588 effector binding site; other site 1160717001589 active site 1160717001590 Zn binding site [ion binding]; other site 1160717001591 glycine loop; other site 1160717001592 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1160717001593 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1160717001594 Ca binding site [ion binding]; other site 1160717001595 active site 1160717001596 catalytic site [active] 1160717001597 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1160717001598 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1160717001599 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1160717001600 active site turn [active] 1160717001601 phosphorylation site [posttranslational modification] 1160717001602 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1160717001603 trehalose repressor; Provisional; Region: treR; PRK09492 1160717001604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717001605 DNA binding site [nucleotide binding] 1160717001606 domain linker motif; other site 1160717001607 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1160717001608 dimerization interface [polypeptide binding]; other site 1160717001609 ligand binding site [chemical binding]; other site 1160717001610 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1160717001611 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1160717001612 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1160717001613 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1160717001614 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1160717001615 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1160717001616 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1160717001617 Transposase; Region: HTH_Tnp_1; cl17663 1160717001618 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1160717001619 homotrimer interaction site [polypeptide binding]; other site 1160717001620 putative active site [active] 1160717001621 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1160717001622 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1160717001623 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1160717001624 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1160717001625 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1160717001626 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1160717001627 pyrBI operon leader peptide; Provisional; Region: PRK10224 1160717001628 Arginine repressor [Transcription]; Region: ArgR; COG1438 1160717001629 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1160717001630 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1160717001631 Predicted membrane protein [Function unknown]; Region: COG1288 1160717001632 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1160717001633 ornithine carbamoyltransferase; Validated; Region: PRK02102 1160717001634 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1160717001635 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1160717001636 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1160717001637 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1160717001638 putative substrate binding site [chemical binding]; other site 1160717001639 nucleotide binding site [chemical binding]; other site 1160717001640 nucleotide binding site [chemical binding]; other site 1160717001641 homodimer interface [polypeptide binding]; other site 1160717001642 arginine deiminase; Provisional; Region: PRK01388 1160717001643 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1160717001644 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1160717001645 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1160717001646 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1160717001647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1160717001648 RNase E inhibitor protein; Provisional; Region: PRK11191 1160717001649 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1160717001650 putative phage 1160717001651 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1160717001652 active site 1160717001653 dinuclear metal binding site [ion binding]; other site 1160717001654 dimerization interface [polypeptide binding]; other site 1160717001655 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1160717001656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1160717001657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717001658 Coenzyme A binding pocket [chemical binding]; other site 1160717001659 Predicted membrane protein [Function unknown]; Region: COG4269 1160717001660 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1160717001661 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1160717001662 HIGH motif; other site 1160717001663 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1160717001664 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1160717001665 active site 1160717001666 KMSKS motif; other site 1160717001667 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1160717001668 tRNA binding surface [nucleotide binding]; other site 1160717001669 anticodon binding site; other site 1160717001670 DNA polymerase III subunit chi; Validated; Region: PRK05728 1160717001671 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1160717001672 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1160717001673 interface (dimer of trimers) [polypeptide binding]; other site 1160717001674 Substrate-binding/catalytic site; other site 1160717001675 Zn-binding sites [ion binding]; other site 1160717001676 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1160717001677 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1160717001678 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1160717001679 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1160717001680 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1160717001681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717001682 DNA binding site [nucleotide binding] 1160717001683 domain linker motif; other site 1160717001684 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1160717001685 putative dimerization interface [polypeptide binding]; other site 1160717001686 putative ligand binding site [chemical binding]; other site 1160717001687 gluconate transporter; Region: gntP; TIGR00791 1160717001688 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1160717001689 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1160717001690 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1160717001691 NADP binding site [chemical binding]; other site 1160717001692 homodimer interface [polypeptide binding]; other site 1160717001693 active site 1160717001694 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1160717001695 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1160717001696 putative NAD(P) binding site [chemical binding]; other site 1160717001697 catalytic Zn binding site [ion binding]; other site 1160717001698 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1160717001699 ATP-binding site [chemical binding]; other site 1160717001700 Gluconate-6-phosphate binding site [chemical binding]; other site 1160717001701 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1160717001702 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1160717001703 putative NAD(P) binding site [chemical binding]; other site 1160717001704 putative substrate binding site [chemical binding]; other site 1160717001705 catalytic Zn binding site [ion binding]; other site 1160717001706 structural Zn binding site [ion binding]; other site 1160717001707 dimer interface [polypeptide binding]; other site 1160717001708 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1160717001709 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1160717001710 HNH endonuclease; Region: HNH_2; pfam13391 1160717001711 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1160717001712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717001713 ATP binding site [chemical binding]; other site 1160717001714 putative Mg++ binding site [ion binding]; other site 1160717001715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717001716 nucleotide binding region [chemical binding]; other site 1160717001717 ATP-binding site [chemical binding]; other site 1160717001718 genomic island 1160717001719 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1160717001720 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1160717001721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717001722 ATP binding site [chemical binding]; other site 1160717001723 putative Mg++ binding site [ion binding]; other site 1160717001724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717001725 ATP-binding site [chemical binding]; other site 1160717001726 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1160717001727 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1160717001728 Part of AAA domain; Region: AAA_19; pfam13245 1160717001729 Family description; Region: UvrD_C_2; pfam13538 1160717001730 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1160717001731 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1160717001732 dimer interface [polypeptide binding]; other site 1160717001733 Mn binding site [ion binding]; other site 1160717001734 K binding site [ion binding]; other site 1160717001735 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1160717001736 HNH endonuclease; Region: HNH_2; pfam13391 1160717001737 hypothetical protein; Provisional; Region: PRK12378 1160717001738 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1160717001739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717001740 S-adenosylmethionine binding site [chemical binding]; other site 1160717001741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717001742 S-adenosylmethionine binding site [chemical binding]; other site 1160717001743 hypothetical protein; Provisional; Region: PRK13687 1160717001744 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1160717001745 Protein of unknown function DUF91; Region: DUF91; cl00709 1160717001746 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1160717001747 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1160717001748 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1160717001749 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1160717001750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717001751 DNA-binding site [nucleotide binding]; DNA binding site 1160717001752 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1160717001753 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1160717001754 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1160717001755 active site 1160717001756 HIGH motif; other site 1160717001757 dimer interface [polypeptide binding]; other site 1160717001758 KMSKS motif; other site 1160717001759 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1160717001760 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1160717001761 aspartate racemase; Region: asp_race; TIGR00035 1160717001762 cell density-dependent motility repressor; Provisional; Region: PRK10082 1160717001763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717001764 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717001765 dimerization interface [polypeptide binding]; other site 1160717001766 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1160717001767 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1160717001768 dimer interface [polypeptide binding]; other site 1160717001769 active site 1160717001770 hypothetical protein; Provisional; Region: PRK10519 1160717001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1160717001772 Nucleoside recognition; Region: Gate; pfam07670 1160717001773 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1160717001774 Predicted membrane protein [Function unknown]; Region: COG2733 1160717001775 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1160717001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717001777 putative substrate translocation pore; other site 1160717001778 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1160717001779 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1160717001780 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1160717001781 NAD(P) binding site [chemical binding]; other site 1160717001782 catalytic residues [active] 1160717001783 endoribonuclease SymE; Provisional; Region: PRK13605 1160717001784 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1160717001785 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1160717001786 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1160717001787 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1160717001788 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1160717001789 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1160717001790 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1160717001791 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1160717001792 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717001793 ATP binding site [chemical binding]; other site 1160717001794 putative Mg++ binding site [ion binding]; other site 1160717001795 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1160717001796 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1160717001797 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 1160717001798 Restriction endonuclease; Region: Mrr_cat; pfam04471 1160717001799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1160717001800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1160717001801 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1160717001802 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1160717001803 P-loop, Walker A motif; other site 1160717001804 Base recognition motif; other site 1160717001805 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1160717001806 Uncharacterized small protein [Function unknown]; Region: COG2879 1160717001807 carbon starvation protein A; Provisional; Region: PRK15015 1160717001808 Carbon starvation protein CstA; Region: CstA; pfam02554 1160717001809 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1160717001810 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1160717001811 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1160717001812 dimer interface [polypeptide binding]; other site 1160717001813 ligand binding site [chemical binding]; other site 1160717001814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717001815 dimerization interface [polypeptide binding]; other site 1160717001816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717001817 dimer interface [polypeptide binding]; other site 1160717001818 putative CheW interface [polypeptide binding]; other site 1160717001819 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1160717001820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717001821 Walker A motif; other site 1160717001822 ATP binding site [chemical binding]; other site 1160717001823 Walker B motif; other site 1160717001824 arginine finger; other site 1160717001825 Transcriptional antiterminator [Transcription]; Region: COG3933 1160717001826 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717001827 active pocket/dimerization site; other site 1160717001828 active site 1160717001829 phosphorylation site [posttranslational modification] 1160717001830 PRD domain; Region: PRD; pfam00874 1160717001831 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717001832 active pocket/dimerization site; other site 1160717001833 active site 1160717001834 phosphorylation site [posttranslational modification] 1160717001835 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1160717001836 active site 1160717001837 phosphorylation site [posttranslational modification] 1160717001838 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1160717001839 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1160717001840 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1160717001841 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1160717001842 dimer interface [polypeptide binding]; other site 1160717001843 active site 1160717001844 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1160717001845 dimer interface [polypeptide binding]; other site 1160717001846 active site 1160717001847 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1160717001848 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1160717001849 putative active site [active] 1160717001850 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1160717001851 phosphoglycerol transferase I; Provisional; Region: PRK03776 1160717001852 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1160717001853 hypothetical protein; Provisional; Region: PRK11667 1160717001854 DNA replication protein DnaC; Validated; Region: PRK07952 1160717001855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717001856 Walker A motif; other site 1160717001857 ATP binding site [chemical binding]; other site 1160717001858 Walker B motif; other site 1160717001859 primosomal protein DnaI; Provisional; Region: PRK02854 1160717001860 hypothetical protein; Provisional; Region: PRK09917 1160717001861 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1160717001862 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1160717001863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1160717001864 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717001865 DNA binding residues [nucleotide binding] 1160717001866 dimerization interface [polypeptide binding]; other site 1160717001867 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1160717001868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717001869 DNA binding residues [nucleotide binding] 1160717001870 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1160717001871 putative deacylase active site [active] 1160717001872 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1160717001873 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1160717001874 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1160717001875 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1160717001876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717001877 metal binding site [ion binding]; metal-binding site 1160717001878 active site 1160717001879 I-site; other site 1160717001880 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1160717001881 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1160717001882 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1160717001883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717001884 S-adenosylmethionine binding site [chemical binding]; other site 1160717001885 DNA polymerase III subunit psi; Validated; Region: PRK06856 1160717001886 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1160717001887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717001888 Coenzyme A binding pocket [chemical binding]; other site 1160717001889 dUMP phosphatase; Provisional; Region: PRK09449 1160717001890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717001891 motif II; other site 1160717001892 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1160717001893 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1160717001894 G1 box; other site 1160717001895 putative GEF interaction site [polypeptide binding]; other site 1160717001896 GTP/Mg2+ binding site [chemical binding]; other site 1160717001897 Switch I region; other site 1160717001898 G2 box; other site 1160717001899 G3 box; other site 1160717001900 Switch II region; other site 1160717001901 G4 box; other site 1160717001902 G5 box; other site 1160717001903 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1160717001904 periplasmic protein; Provisional; Region: PRK10568 1160717001905 BON domain; Region: BON; pfam04972 1160717001906 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1160717001907 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1160717001908 active site 1160717001909 nucleophile elbow; other site 1160717001910 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1160717001911 active site 1160717001912 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1160717001913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717001914 FeS/SAM binding site; other site 1160717001915 hypothetical protein; Provisional; Region: PRK10977 1160717001916 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1160717001917 intersubunit interface [polypeptide binding]; other site 1160717001918 active site 1160717001919 catalytic residue [active] 1160717001920 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1160717001921 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1160717001922 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1160717001923 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1160717001924 phosphopentomutase; Provisional; Region: PRK05362 1160717001925 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1160717001926 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1160717001927 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1160717001928 hypothetical protein; Provisional; Region: PRK15301 1160717001929 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1160717001930 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717001931 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717001932 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717001933 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1160717001934 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717001935 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717001936 hypothetical protein; Provisional; Region: PRK15302 1160717001937 hypothetical protein; Provisional; Region: PRK15303 1160717001938 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1160717001939 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1160717001940 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1160717001941 hypothetical protein; Provisional; Region: PRK11246 1160717001942 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1160717001943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717001944 motif II; other site 1160717001945 DNA repair protein RadA; Region: sms; TIGR00416 1160717001946 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1160717001947 Walker A motif/ATP binding site; other site 1160717001948 ATP binding site [chemical binding]; other site 1160717001949 Walker B motif; other site 1160717001950 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1160717001951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717001952 non-specific DNA binding site [nucleotide binding]; other site 1160717001953 salt bridge; other site 1160717001954 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1160717001955 sequence-specific DNA binding site [nucleotide binding]; other site 1160717001956 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1160717001957 active site 1160717001958 (T/H)XGH motif; other site 1160717001959 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1160717001960 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1160717001961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717001962 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717001963 ABC transporter; Region: ABC_tran_2; pfam12848 1160717001964 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717001965 lytic murein transglycosylase; Provisional; Region: PRK11619 1160717001966 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717001967 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717001968 catalytic residue [active] 1160717001969 Trp operon repressor; Provisional; Region: PRK01381 1160717001970 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1160717001971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1160717001972 catalytic core [active] 1160717001973 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1160717001974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717001975 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1160717001976 hypothetical protein; Provisional; Region: PRK10756 1160717001977 CreA protein; Region: CreA; pfam05981 1160717001978 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1160717001979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717001980 active site 1160717001981 phosphorylation site [posttranslational modification] 1160717001982 intermolecular recognition site; other site 1160717001983 dimerization interface [polypeptide binding]; other site 1160717001984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717001985 DNA binding site [nucleotide binding] 1160717001986 sensory histidine kinase CreC; Provisional; Region: PRK11100 1160717001987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1160717001988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717001989 dimer interface [polypeptide binding]; other site 1160717001990 phosphorylation site [posttranslational modification] 1160717001991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717001992 ATP binding site [chemical binding]; other site 1160717001993 Mg2+ binding site [ion binding]; other site 1160717001994 G-X-G motif; other site 1160717001995 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1160717001996 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1160717001997 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1160717001998 putative fimbrial protein SthD; Provisional; Region: PRK15293 1160717001999 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 1160717002000 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717002001 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717002002 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717002003 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1160717002004 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717002005 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717002006 putative fimbrial protein SthA; Provisional; Region: PRK15296 1160717002007 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1160717002008 Helix-turn-helix domain; Region: HTH_36; pfam13730 1160717002009 two-component response regulator; Provisional; Region: PRK11173 1160717002010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717002011 active site 1160717002012 phosphorylation site [posttranslational modification] 1160717002013 intermolecular recognition site; other site 1160717002014 dimerization interface [polypeptide binding]; other site 1160717002015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717002016 DNA binding site [nucleotide binding] 1160717002017 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1160717002018 putative RNA methyltransferase; Provisional; Region: PRK10433 1160717002019 Thr_leader; SU5_nc25 1160717002020 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1160717002021 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1160717002022 putative catalytic residues [active] 1160717002023 putative nucleotide binding site [chemical binding]; other site 1160717002024 putative aspartate binding site [chemical binding]; other site 1160717002025 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1160717002026 dimer interface [polypeptide binding]; other site 1160717002027 putative threonine allosteric regulatory site; other site 1160717002028 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1160717002029 putative threonine allosteric regulatory site; other site 1160717002030 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1160717002031 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1160717002032 homoserine kinase; Provisional; Region: PRK01212 1160717002033 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1160717002034 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1160717002035 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1160717002036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717002037 catalytic residue [active] 1160717002038 hypothetical protein; Validated; Region: PRK02101 1160717002039 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1160717002040 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1160717002041 transaldolase-like protein; Provisional; Region: PTZ00411 1160717002042 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1160717002043 active site 1160717002044 dimer interface [polypeptide binding]; other site 1160717002045 catalytic residue [active] 1160717002046 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1160717002047 MPT binding site; other site 1160717002048 trimer interface [polypeptide binding]; other site 1160717002049 hypothetical protein; Provisional; Region: PRK10659 1160717002050 hypothetical protein; Provisional; Region: PRK10236 1160717002051 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1160717002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1160717002053 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 1160717002054 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1160717002055 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1160717002056 nucleotide binding site [chemical binding]; other site 1160717002057 chaperone protein DnaJ; Provisional; Region: PRK10767 1160717002058 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1160717002059 HSP70 interaction site [polypeptide binding]; other site 1160717002060 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1160717002061 substrate binding site [polypeptide binding]; other site 1160717002062 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1160717002063 Zn binding sites [ion binding]; other site 1160717002064 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1160717002065 dimer interface [polypeptide binding]; other site 1160717002066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717002067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717002068 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1160717002069 substrate binding pocket [chemical binding]; other site 1160717002070 dimerization interface [polypeptide binding]; other site 1160717002071 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1160717002072 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1160717002073 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1160717002074 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1160717002075 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1160717002076 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1160717002077 active site 1160717002078 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1160717002079 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1160717002080 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1160717002081 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1160717002082 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1160717002083 Helix-turn-helix domain; Region: HTH_36; pfam13730 1160717002084 fimbrial protein BcfA; Provisional; Region: PRK15187 1160717002085 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 1160717002086 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717002087 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717002088 outer membrane usher protein; Provisional; Region: PRK15193 1160717002089 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717002090 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717002091 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717002092 genomic island 1160717002093 fimbrial protein BcfD; Provisional; Region: PRK15189 1160717002094 fimbrial protein BcfE; Provisional; Region: PRK15190 1160717002095 fimbrial protein BcfF; Provisional; Region: PRK15191 1160717002096 fimbrial chaperone BcfG; Provisional; Region: PRK15192 1160717002097 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717002098 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717002099 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1160717002100 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1160717002101 catalytic residues [active] 1160717002102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1160717002103 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1160717002104 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1160717002105 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1160717002106 Sulfatase; Region: Sulfatase; pfam00884 1160717002107 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1160717002108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717002109 FeS/SAM binding site; other site 1160717002110 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1160717002111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1160717002112 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1160717002113 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1160717002114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717002115 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1160717002116 putative dimerization interface [polypeptide binding]; other site 1160717002117 putative alpha-glucosidase; Provisional; Region: PRK10658 1160717002118 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1160717002119 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1160717002120 putative active site [active] 1160717002121 putative catalytic site [active] 1160717002122 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1160717002123 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1160717002124 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1160717002125 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1160717002126 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1160717002127 active site 1160717002128 Riboflavin kinase; Region: Flavokinase; smart00904 1160717002129 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1160717002130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1160717002131 active site 1160717002132 HIGH motif; other site 1160717002133 nucleotide binding site [chemical binding]; other site 1160717002134 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1160717002135 active site 1160717002136 KMSKS motif; other site 1160717002137 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1160717002138 tRNA binding surface [nucleotide binding]; other site 1160717002139 anticodon binding site; other site 1160717002140 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1160717002141 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1160717002142 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1160717002143 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1160717002144 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1160717002145 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1160717002146 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1160717002147 active site 1160717002148 tetramer interface [polypeptide binding]; other site 1160717002149 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1160717002150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717002151 active site 1160717002152 phosphorylation site [posttranslational modification] 1160717002153 intermolecular recognition site; other site 1160717002154 dimerization interface [polypeptide binding]; other site 1160717002155 Transcriptional regulator; Region: CitT; pfam12431 1160717002156 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1160717002157 PAS domain; Region: PAS; smart00091 1160717002158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717002159 ATP binding site [chemical binding]; other site 1160717002160 Mg2+ binding site [ion binding]; other site 1160717002161 G-X-G motif; other site 1160717002162 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1160717002163 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1160717002164 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1160717002165 active site 1160717002166 catalytic residues [active] 1160717002167 metal binding site [ion binding]; metal-binding site 1160717002168 homodimer binding site [polypeptide binding]; other site 1160717002169 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1160717002170 carboxyltransferase (CT) interaction site; other site 1160717002171 biotinylation site [posttranslational modification]; other site 1160717002172 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1160717002173 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1160717002174 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1160717002175 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1160717002176 putative active site [active] 1160717002177 (T/H)XGH motif; other site 1160717002178 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1160717002179 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1160717002180 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1160717002181 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1160717002182 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1160717002183 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1160717002184 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1160717002185 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1160717002186 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1160717002187 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 1160717002188 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1160717002189 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1160717002190 catalytic site [active] 1160717002191 subunit interface [polypeptide binding]; other site 1160717002192 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1160717002193 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1160717002194 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1160717002195 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1160717002196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1160717002197 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1160717002198 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1160717002199 IMP binding site; other site 1160717002200 dimer interface [polypeptide binding]; other site 1160717002201 interdomain contacts; other site 1160717002202 partial ornithine binding site; other site 1160717002203 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1160717002204 carnitine operon protein CaiE; Provisional; Region: PRK13627 1160717002205 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1160717002206 putative trimer interface [polypeptide binding]; other site 1160717002207 putative metal binding site [ion binding]; other site 1160717002208 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1160717002209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1160717002210 substrate binding site [chemical binding]; other site 1160717002211 oxyanion hole (OAH) forming residues; other site 1160717002212 trimer interface [polypeptide binding]; other site 1160717002213 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1160717002214 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1160717002215 acyl-activating enzyme (AAE) consensus motif; other site 1160717002216 putative AMP binding site [chemical binding]; other site 1160717002217 putative active site [active] 1160717002218 putative CoA binding site [chemical binding]; other site 1160717002219 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1160717002220 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1160717002221 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1160717002222 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1160717002223 active site 1160717002224 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1160717002225 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1160717002226 Ligand binding site [chemical binding]; other site 1160717002227 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1160717002228 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1160717002229 Electron transfer flavoprotein domain; Region: ETF; smart00893 1160717002230 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1160717002231 putative oxidoreductase FixC; Provisional; Region: PRK10157 1160717002232 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1160717002233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717002234 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1160717002235 putative substrate translocation pore; other site 1160717002236 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1160717002237 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717002238 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1160717002239 Sulfatase; Region: Sulfatase; cl17466 1160717002240 Sulfatase; Region: Sulfatase; cl17466 1160717002241 Sulfatase; Region: Sulfatase; cl17466 1160717002242 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1160717002243 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1160717002244 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1160717002245 TrkA-N domain; Region: TrkA_N; pfam02254 1160717002246 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1160717002247 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1160717002248 folate binding site [chemical binding]; other site 1160717002249 NADP+ binding site [chemical binding]; other site 1160717002250 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1160717002251 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1160717002252 active site 1160717002253 metal binding site [ion binding]; metal-binding site 1160717002254 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1160717002255 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1160717002256 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1160717002257 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1160717002258 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1160717002259 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1160717002260 SurA N-terminal domain; Region: SurA_N; pfam09312 1160717002261 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1160717002262 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1160717002263 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1160717002264 OstA-like protein; Region: OstA; pfam03968 1160717002265 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1160717002266 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1160717002267 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1160717002268 putative metal binding site [ion binding]; other site 1160717002269 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1160717002270 HSP70 interaction site [polypeptide binding]; other site 1160717002271 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1160717002272 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1160717002273 active site 1160717002274 ATP-dependent helicase HepA; Validated; Region: PRK04914 1160717002275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717002276 ATP binding site [chemical binding]; other site 1160717002277 putative Mg++ binding site [ion binding]; other site 1160717002278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717002279 nucleotide binding region [chemical binding]; other site 1160717002280 ATP-binding site [chemical binding]; other site 1160717002281 DNA polymerase II; Reviewed; Region: PRK05762 1160717002282 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1160717002283 active site 1160717002284 catalytic site [active] 1160717002285 substrate binding site [chemical binding]; other site 1160717002286 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1160717002287 active site 1160717002288 metal-binding site 1160717002289 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1160717002290 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1160717002291 putative active site [active] 1160717002292 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1160717002293 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1160717002294 intersubunit interface [polypeptide binding]; other site 1160717002295 active site 1160717002296 Zn2+ binding site [ion binding]; other site 1160717002297 L-arabinose isomerase; Provisional; Region: PRK02929 1160717002298 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1160717002299 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1160717002300 trimer interface [polypeptide binding]; other site 1160717002301 putative substrate binding site [chemical binding]; other site 1160717002302 putative metal binding site [ion binding]; other site 1160717002303 ribulokinase; Provisional; Region: PRK04123 1160717002304 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1160717002305 N- and C-terminal domain interface [polypeptide binding]; other site 1160717002306 active site 1160717002307 MgATP binding site [chemical binding]; other site 1160717002308 catalytic site [active] 1160717002309 metal binding site [ion binding]; metal-binding site 1160717002310 carbohydrate binding site [chemical binding]; other site 1160717002311 homodimer interface [polypeptide binding]; other site 1160717002312 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1160717002313 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1160717002314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717002315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717002316 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1160717002317 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1160717002318 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1160717002319 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1160717002320 Walker A/P-loop; other site 1160717002321 ATP binding site [chemical binding]; other site 1160717002322 Q-loop/lid; other site 1160717002323 ABC transporter signature motif; other site 1160717002324 Walker B; other site 1160717002325 D-loop; other site 1160717002326 H-loop/switch region; other site 1160717002327 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1160717002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717002329 dimer interface [polypeptide binding]; other site 1160717002330 conserved gate region; other site 1160717002331 putative PBP binding loops; other site 1160717002332 ABC-ATPase subunit interface; other site 1160717002333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717002334 dimer interface [polypeptide binding]; other site 1160717002335 conserved gate region; other site 1160717002336 putative PBP binding loops; other site 1160717002337 ABC-ATPase subunit interface; other site 1160717002338 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1160717002339 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1160717002340 transcriptional regulator SgrR; Provisional; Region: PRK13626 1160717002341 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1160717002342 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1160717002343 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1160717002344 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1160717002345 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1160717002346 substrate binding site [chemical binding]; other site 1160717002347 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1160717002348 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1160717002349 substrate binding site [chemical binding]; other site 1160717002350 ligand binding site [chemical binding]; other site 1160717002351 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1160717002352 tartrate dehydrogenase; Region: TTC; TIGR02089 1160717002353 2-isopropylmalate synthase; Validated; Region: PRK00915 1160717002354 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1160717002355 active site 1160717002356 catalytic residues [active] 1160717002357 metal binding site [ion binding]; metal-binding site 1160717002358 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1160717002359 Leu leader; SU5_nc30 1160717002360 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1160717002361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717002362 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1160717002363 putative substrate binding pocket [chemical binding]; other site 1160717002364 putative dimerization interface [polypeptide binding]; other site 1160717002365 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1160717002366 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1160717002367 PYR/PP interface [polypeptide binding]; other site 1160717002368 dimer interface [polypeptide binding]; other site 1160717002369 TPP binding site [chemical binding]; other site 1160717002370 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1160717002371 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1160717002372 TPP-binding site [chemical binding]; other site 1160717002373 dimer interface [polypeptide binding]; other site 1160717002374 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1160717002375 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1160717002376 putative valine binding site [chemical binding]; other site 1160717002377 dimer interface [polypeptide binding]; other site 1160717002378 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1160717002379 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1160717002380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717002381 DNA binding site [nucleotide binding] 1160717002382 domain linker motif; other site 1160717002383 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1160717002384 dimerization interface [polypeptide binding]; other site 1160717002385 ligand binding site [chemical binding]; other site 1160717002386 mraZ protein; Region: TIGR00242 1160717002387 MraZ protein; Region: MraZ; pfam02381 1160717002388 MraZ protein; Region: MraZ; pfam02381 1160717002389 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1160717002390 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1160717002391 cell division protein FtsL; Provisional; Region: PRK10772 1160717002392 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1160717002393 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1160717002394 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1160717002395 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1160717002396 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1160717002397 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1160717002398 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1160717002399 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1160717002400 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1160717002401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1160717002402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1160717002403 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1160717002404 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1160717002405 Mg++ binding site [ion binding]; other site 1160717002406 putative catalytic motif [active] 1160717002407 putative substrate binding site [chemical binding]; other site 1160717002408 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1160717002409 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1160717002410 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1160717002411 cell division protein FtsW; Provisional; Region: PRK10774 1160717002412 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1160717002413 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1160717002414 active site 1160717002415 homodimer interface [polypeptide binding]; other site 1160717002416 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1160717002417 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1160717002418 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1160717002419 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1160717002420 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1160717002421 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1160717002422 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1160717002423 cell division protein FtsQ; Provisional; Region: PRK10775 1160717002424 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1160717002425 Cell division protein FtsQ; Region: FtsQ; pfam03799 1160717002426 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1160717002427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717002428 Cell division protein FtsA; Region: FtsA; pfam14450 1160717002429 cell division protein FtsZ; Validated; Region: PRK09330 1160717002430 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1160717002431 nucleotide binding site [chemical binding]; other site 1160717002432 SulA interaction site; other site 1160717002433 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1160717002434 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1160717002435 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1160717002436 SecA regulator SecM; Provisional; Region: PRK02943 1160717002437 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1160717002438 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1160717002439 SEC-C motif; Region: SEC-C; pfam02810 1160717002440 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1160717002441 active site 1160717002442 8-oxo-dGMP binding site [chemical binding]; other site 1160717002443 nudix motif; other site 1160717002444 metal binding site [ion binding]; metal-binding site 1160717002445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1160717002446 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1160717002447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1160717002448 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1160717002449 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1160717002450 CoA-binding site [chemical binding]; other site 1160717002451 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1160717002452 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1160717002453 active site 1160717002454 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1160717002455 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1160717002456 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1160717002457 hypothetical protein; Provisional; Region: PRK10436 1160717002458 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1160717002459 Walker A motif; other site 1160717002460 ATP binding site [chemical binding]; other site 1160717002461 Walker B motif; other site 1160717002462 putative major pilin subunit; Provisional; Region: PRK10574 1160717002463 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1160717002464 Pilin (bacterial filament); Region: Pilin; pfam00114 1160717002465 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1160717002466 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1160717002467 dimerization interface [polypeptide binding]; other site 1160717002468 active site 1160717002469 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1160717002470 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1160717002471 amidase catalytic site [active] 1160717002472 Zn binding residues [ion binding]; other site 1160717002473 substrate binding site [chemical binding]; other site 1160717002474 regulatory protein AmpE; Provisional; Region: PRK10987 1160717002475 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1160717002476 active site 1160717002477 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1160717002478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717002479 putative substrate translocation pore; other site 1160717002480 aromatic amino acid transporter; Provisional; Region: PRK10238 1160717002481 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1160717002482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717002483 DNA-binding site [nucleotide binding]; DNA binding site 1160717002484 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1160717002485 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1160717002486 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1160717002487 dimer interface [polypeptide binding]; other site 1160717002488 TPP-binding site [chemical binding]; other site 1160717002489 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1160717002490 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1160717002491 E3 interaction surface; other site 1160717002492 lipoyl attachment site [posttranslational modification]; other site 1160717002493 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1160717002494 E3 interaction surface; other site 1160717002495 lipoyl attachment site [posttranslational modification]; other site 1160717002496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1160717002497 E3 interaction surface; other site 1160717002498 lipoyl attachment site [posttranslational modification]; other site 1160717002499 e3 binding domain; Region: E3_binding; pfam02817 1160717002500 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1160717002501 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1160717002502 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1160717002503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717002504 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1160717002505 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1160717002506 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1160717002507 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1160717002508 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1160717002509 substrate binding site [chemical binding]; other site 1160717002510 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1160717002511 substrate binding site [chemical binding]; other site 1160717002512 ligand binding site [chemical binding]; other site 1160717002513 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1160717002514 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1160717002515 putative inner membrane protein; Provisional; Region: PRK09823 1160717002516 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1160717002517 active site 1160717002518 hypothetical protein; Provisional; Region: PRK05248 1160717002519 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1160717002520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1160717002521 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1160717002522 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1160717002523 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1160717002524 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717002525 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717002526 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717002527 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1160717002528 spermidine synthase; Provisional; Region: PRK00811 1160717002529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717002530 S-adenosylmethionine binding site [chemical binding]; other site 1160717002531 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1160717002532 multicopper oxidase; Provisional; Region: PRK10965 1160717002533 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1160717002534 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1160717002535 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1160717002536 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1160717002537 Trp docking motif [polypeptide binding]; other site 1160717002538 putative active site [active] 1160717002539 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1160717002540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717002541 active site 1160717002542 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1160717002543 active site clefts [active] 1160717002544 zinc binding site [ion binding]; other site 1160717002545 dimer interface [polypeptide binding]; other site 1160717002546 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1160717002547 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1160717002548 Walker A/P-loop; other site 1160717002549 ATP binding site [chemical binding]; other site 1160717002550 Q-loop/lid; other site 1160717002551 ABC transporter signature motif; other site 1160717002552 Walker B; other site 1160717002553 D-loop; other site 1160717002554 H-loop/switch region; other site 1160717002555 inner membrane transport permease; Provisional; Region: PRK15066 1160717002556 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1160717002557 putative fimbrial protein StiH; Provisional; Region: PRK15297 1160717002558 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 1160717002559 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717002560 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717002561 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717002562 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 1160717002563 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717002564 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717002565 fimbrial protein StiA; Provisional; Region: PRK15300 1160717002566 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717002567 active pocket/dimerization site; other site 1160717002568 active site 1160717002569 phosphorylation site [posttranslational modification] 1160717002570 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1160717002571 putative active site [active] 1160717002572 putative metal binding site [ion binding]; other site 1160717002573 putative fimbrial protein StkG; Provisional; Region: PRK15305 1160717002574 putative fimbrial protein StaF; Provisional; Region: PRK15262 1160717002575 putative fimbrial protein StaE; Provisional; Region: PRK15263 1160717002576 putative fimbrial protein StkD; Provisional; Region: PRK15306 1160717002577 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1160717002578 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717002579 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717002580 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717002581 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1160717002582 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717002583 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717002584 major fimbrial protein StkA; Provisional; Region: PRK15307 1160717002585 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1160717002586 tetramerization interface [polypeptide binding]; other site 1160717002587 active site 1160717002588 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1160717002589 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1160717002590 active site 1160717002591 ATP-binding site [chemical binding]; other site 1160717002592 pantoate-binding site; other site 1160717002593 HXXH motif; other site 1160717002594 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1160717002595 oligomerization interface [polypeptide binding]; other site 1160717002596 active site 1160717002597 metal binding site [ion binding]; metal-binding site 1160717002598 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1160717002599 catalytic center binding site [active] 1160717002600 ATP binding site [chemical binding]; other site 1160717002601 poly(A) polymerase; Region: pcnB; TIGR01942 1160717002602 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1160717002603 active site 1160717002604 NTP binding site [chemical binding]; other site 1160717002605 metal binding triad [ion binding]; metal-binding site 1160717002606 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1160717002607 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1160717002608 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1160717002609 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1160717002610 active site 1160717002611 nucleotide binding site [chemical binding]; other site 1160717002612 HIGH motif; other site 1160717002613 KMSKS motif; other site 1160717002614 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1160717002615 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1160717002616 2'-5' RNA ligase; Provisional; Region: PRK15124 1160717002617 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1160717002618 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1160717002619 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1160717002620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717002621 ATP binding site [chemical binding]; other site 1160717002622 putative Mg++ binding site [ion binding]; other site 1160717002623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717002624 nucleotide binding region [chemical binding]; other site 1160717002625 ATP-binding site [chemical binding]; other site 1160717002626 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1160717002627 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1160717002628 Transglycosylase; Region: Transgly; pfam00912 1160717002629 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1160717002630 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1160717002631 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1160717002632 Walker A/P-loop; other site 1160717002633 ATP binding site [chemical binding]; other site 1160717002634 Q-loop/lid; other site 1160717002635 ABC transporter signature motif; other site 1160717002636 Walker B; other site 1160717002637 D-loop; other site 1160717002638 H-loop/switch region; other site 1160717002639 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1160717002640 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1160717002641 siderophore binding site; other site 1160717002642 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1160717002643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717002644 ABC-ATPase subunit interface; other site 1160717002645 dimer interface [polypeptide binding]; other site 1160717002646 putative PBP binding regions; other site 1160717002647 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717002648 ABC-ATPase subunit interface; other site 1160717002649 dimer interface [polypeptide binding]; other site 1160717002650 putative PBP binding regions; other site 1160717002651 putative fimbrial subunit StfA; Provisional; Region: PRK15283 1160717002652 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1160717002653 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717002654 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717002655 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717002656 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1160717002657 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717002658 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717002659 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 1160717002660 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 1160717002661 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 1160717002662 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1160717002663 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1160717002664 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1160717002665 inhibitor-cofactor binding pocket; inhibition site 1160717002666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717002667 catalytic residue [active] 1160717002668 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1160717002669 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1160717002670 Cl- selectivity filter; other site 1160717002671 Cl- binding residues [ion binding]; other site 1160717002672 pore gating glutamate residue; other site 1160717002673 dimer interface [polypeptide binding]; other site 1160717002674 H+/Cl- coupling transport residue; other site 1160717002675 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1160717002676 hypothetical protein; Provisional; Region: PRK10578 1160717002677 UPF0126 domain; Region: UPF0126; pfam03458 1160717002678 UPF0126 domain; Region: UPF0126; pfam03458 1160717002679 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1160717002680 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1160717002681 cobalamin binding residues [chemical binding]; other site 1160717002682 putative BtuC binding residues; other site 1160717002683 dimer interface [polypeptide binding]; other site 1160717002684 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1160717002685 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1160717002686 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1160717002687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1160717002688 Zn2+ binding site [ion binding]; other site 1160717002689 Mg2+ binding site [ion binding]; other site 1160717002690 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1160717002691 serine endoprotease; Provisional; Region: PRK10942 1160717002692 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1160717002693 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1160717002694 protein binding site [polypeptide binding]; other site 1160717002695 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1160717002696 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1160717002697 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1160717002698 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1160717002699 hypothetical protein; Provisional; Region: PRK13677 1160717002700 shikimate transporter; Provisional; Region: PRK09952 1160717002701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717002702 putative substrate translocation pore; other site 1160717002703 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1160717002704 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1160717002705 trimer interface [polypeptide binding]; other site 1160717002706 active site 1160717002707 substrate binding site [chemical binding]; other site 1160717002708 CoA binding site [chemical binding]; other site 1160717002709 PII uridylyl-transferase; Provisional; Region: PRK05007 1160717002710 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1160717002711 metal binding triad; other site 1160717002712 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1160717002713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1160717002714 Zn2+ binding site [ion binding]; other site 1160717002715 Mg2+ binding site [ion binding]; other site 1160717002716 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1160717002717 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1160717002718 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1160717002719 active site 1160717002720 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1160717002721 rRNA interaction site [nucleotide binding]; other site 1160717002722 S8 interaction site; other site 1160717002723 putative laminin-1 binding site; other site 1160717002724 elongation factor Ts; Provisional; Region: tsf; PRK09377 1160717002725 UBA/TS-N domain; Region: UBA; pfam00627 1160717002726 Elongation factor TS; Region: EF_TS; pfam00889 1160717002727 Elongation factor TS; Region: EF_TS; pfam00889 1160717002728 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1160717002729 putative nucleotide binding site [chemical binding]; other site 1160717002730 uridine monophosphate binding site [chemical binding]; other site 1160717002731 homohexameric interface [polypeptide binding]; other site 1160717002732 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1160717002733 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1160717002734 hinge region; other site 1160717002735 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1160717002736 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1160717002737 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1160717002738 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1160717002739 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1160717002740 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1160717002741 catalytic residue [active] 1160717002742 putative FPP diphosphate binding site; other site 1160717002743 putative FPP binding hydrophobic cleft; other site 1160717002744 dimer interface [polypeptide binding]; other site 1160717002745 putative IPP diphosphate binding site; other site 1160717002746 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1160717002747 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1160717002748 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1160717002749 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1160717002750 active site 1160717002751 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1160717002752 protein binding site [polypeptide binding]; other site 1160717002753 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1160717002754 protein binding site [polypeptide binding]; other site 1160717002755 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1160717002756 putative substrate binding region [chemical binding]; other site 1160717002757 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1160717002758 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1160717002759 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1160717002760 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1160717002761 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1160717002762 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1160717002763 Surface antigen; Region: Bac_surface_Ag; pfam01103 1160717002764 periplasmic chaperone; Provisional; Region: PRK10780 1160717002765 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1160717002766 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1160717002767 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1160717002768 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1160717002769 trimer interface [polypeptide binding]; other site 1160717002770 active site 1160717002771 UDP-GlcNAc binding site [chemical binding]; other site 1160717002772 lipid binding site [chemical binding]; lipid-binding site 1160717002773 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1160717002774 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1160717002775 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1160717002776 active site 1160717002777 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1160717002778 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1160717002779 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1160717002780 RNA/DNA hybrid binding site [nucleotide binding]; other site 1160717002781 active site 1160717002782 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1160717002783 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1160717002784 putative active site [active] 1160717002785 putative PHP Thumb interface [polypeptide binding]; other site 1160717002786 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1160717002787 generic binding surface II; other site 1160717002788 generic binding surface I; other site 1160717002789 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1160717002790 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1160717002791 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1160717002792 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1160717002793 putative sugar binding site [chemical binding]; other site 1160717002794 catalytic residues [active] 1160717002795 PKD domain; Region: PKD; pfam00801 1160717002796 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1160717002797 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1160717002798 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1160717002799 homodimer interface [polypeptide binding]; other site 1160717002800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717002801 catalytic residue [active] 1160717002802 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1160717002803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1160717002804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1160717002805 putative metal binding site [ion binding]; other site 1160717002806 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1160717002807 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1160717002808 Ligand Binding Site [chemical binding]; other site 1160717002809 TilS substrate binding domain; Region: TilS; pfam09179 1160717002810 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1160717002811 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1160717002812 hypothetical protein; Provisional; Region: PRK04964 1160717002813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1160717002814 hypothetical protein; Provisional; Region: PRK09256 1160717002815 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1160717002816 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1160717002817 NlpE N-terminal domain; Region: NlpE; pfam04170 1160717002818 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1160717002819 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1160717002820 dimer interface [polypeptide binding]; other site 1160717002821 motif 1; other site 1160717002822 active site 1160717002823 motif 2; other site 1160717002824 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1160717002825 putative deacylase active site [active] 1160717002826 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1160717002827 active site 1160717002828 motif 3; other site 1160717002829 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1160717002830 anticodon binding site; other site 1160717002831 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1160717002832 homodimer interaction site [polypeptide binding]; other site 1160717002833 cofactor binding site; other site 1160717002834 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1160717002835 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1160717002836 lipoprotein, YaeC family; Region: TIGR00363 1160717002837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717002838 dimer interface [polypeptide binding]; other site 1160717002839 conserved gate region; other site 1160717002840 ABC-ATPase subunit interface; other site 1160717002841 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1160717002842 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1160717002843 Walker A/P-loop; other site 1160717002844 ATP binding site [chemical binding]; other site 1160717002845 Q-loop/lid; other site 1160717002846 ABC transporter signature motif; other site 1160717002847 Walker B; other site 1160717002848 D-loop; other site 1160717002849 H-loop/switch region; other site 1160717002850 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1160717002851 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1160717002852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717002853 active site 1160717002854 motif I; other site 1160717002855 motif II; other site 1160717002856 PK-G12rRNA; SU5_nc34 1160717002857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717002858 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717002859 active site 1160717002860 catalytic tetrad [active] 1160717002861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717002862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717002863 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1160717002864 putative effector binding pocket; other site 1160717002865 dimerization interface [polypeptide binding]; other site 1160717002866 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1160717002867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717002868 putative substrate translocation pore; other site 1160717002869 hypothetical protein; Provisional; Region: PRK05421 1160717002870 putative catalytic site [active] 1160717002871 putative metal binding site [ion binding]; other site 1160717002872 putative phosphate binding site [ion binding]; other site 1160717002873 putative catalytic site [active] 1160717002874 putative phosphate binding site [ion binding]; other site 1160717002875 putative metal binding site [ion binding]; other site 1160717002876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717002877 S-adenosylmethionine binding site [chemical binding]; other site 1160717002878 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1160717002879 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717002880 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717002881 catalytic residue [active] 1160717002882 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1160717002883 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717002884 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1160717002885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717002886 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1160717002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717002888 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1160717002889 RNA/DNA hybrid binding site [nucleotide binding]; other site 1160717002890 active site 1160717002891 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1160717002892 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1160717002893 active site 1160717002894 catalytic site [active] 1160717002895 substrate binding site [chemical binding]; other site 1160717002896 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1160717002897 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1160717002898 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1160717002899 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1160717002900 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1160717002901 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1160717002902 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1160717002903 ImpE protein; Region: ImpE; pfam07024 1160717002904 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1160717002905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717002906 Walker A motif; other site 1160717002907 ATP binding site [chemical binding]; other site 1160717002908 Walker B motif; other site 1160717002909 arginine finger; other site 1160717002910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717002911 Walker A motif; other site 1160717002912 ATP binding site [chemical binding]; other site 1160717002913 Walker B motif; other site 1160717002914 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1160717002915 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1160717002916 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1160717002917 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1160717002918 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1160717002919 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1160717002920 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1160717002921 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1160717002922 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1160717002923 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1160717002924 hypothetical protein; Provisional; Region: PRK08126 1160717002925 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1160717002926 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1160717002927 ligand binding site [chemical binding]; other site 1160717002928 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1160717002929 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1160717002930 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1160717002931 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1160717002932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 1160717002933 genomic island 1160717002934 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1160717002935 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1160717002936 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1160717002937 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1160717002938 PAAR motif; Region: PAAR_motif; pfam05488 1160717002939 RHS Repeat; Region: RHS_repeat; cl11982 1160717002940 RHS Repeat; Region: RHS_repeat; cl11982 1160717002941 RHS Repeat; Region: RHS_repeat; cl11982 1160717002942 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002943 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002944 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1160717002945 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002946 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002947 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002948 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002949 RHS Repeat; Region: RHS_repeat; pfam05593 1160717002950 RHS protein; Region: RHS; pfam03527 1160717002951 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1160717002952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1160717002953 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1160717002954 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1160717002955 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 1160717002956 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1160717002957 putative fimbrial protein TcfD; Provisional; Region: PRK15311 1160717002958 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1160717002959 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1160717002960 AsnC family; Region: AsnC_trans_reg; pfam01037 1160717002961 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1160717002962 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1160717002963 dimer interface [polypeptide binding]; other site 1160717002964 C-N hydrolase family amidase; Provisional; Region: PRK10438 1160717002965 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1160717002966 putative active site [active] 1160717002967 catalytic triad [active] 1160717002968 dimer interface [polypeptide binding]; other site 1160717002969 multimer interface [polypeptide binding]; other site 1160717002970 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1160717002971 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1160717002972 active site 1160717002973 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1160717002974 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1160717002975 dimer interface [polypeptide binding]; other site 1160717002976 active site 1160717002977 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1160717002978 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1160717002979 putative active site [active] 1160717002980 putative dimer interface [polypeptide binding]; other site 1160717002981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1160717002982 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717002983 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1160717002984 active site 1160717002985 DNA polymerase IV; Validated; Region: PRK02406 1160717002986 DNA binding site [nucleotide binding] 1160717002987 hypothetical protein; Reviewed; Region: PRK09588 1160717002988 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1160717002989 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1160717002990 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1160717002991 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1160717002992 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1160717002993 metal binding site [ion binding]; metal-binding site 1160717002994 dimer interface [polypeptide binding]; other site 1160717002995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717002996 active site 1160717002997 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1160717002998 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1160717002999 genomic island 1160717003000 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717003001 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717003002 trimer interface [polypeptide binding]; other site 1160717003003 eyelet of channel; other site 1160717003004 gamma-glutamyl kinase; Provisional; Region: PRK05429 1160717003005 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1160717003006 nucleotide binding site [chemical binding]; other site 1160717003007 homotetrameric interface [polypeptide binding]; other site 1160717003008 putative phosphate binding site [ion binding]; other site 1160717003009 putative allosteric binding site; other site 1160717003010 PUA domain; Region: PUA; pfam01472 1160717003011 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1160717003012 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1160717003013 putative catalytic cysteine [active] 1160717003014 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1160717003015 Int/Topo IB signature motif; other site 1160717003016 Helix-turn-helix domain; Region: HTH_17; pfam12728 1160717003017 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1160717003018 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1160717003019 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1160717003020 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1160717003021 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 1160717003022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1160717003023 ERF superfamily; Region: ERF; pfam04404 1160717003024 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 1160717003025 hypothetical protein; Region: PHA01516 1160717003026 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1160717003027 Antirestriction protein Ral; Region: Ral; pfam11058 1160717003028 Superinfection exclusion protein B; Region: SieB; pfam14163 1160717003029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717003030 sequence-specific DNA binding site [nucleotide binding]; other site 1160717003031 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1160717003032 salt bridge; other site 1160717003033 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1160717003034 Catalytic site [active] 1160717003035 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1160717003036 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1160717003037 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1160717003038 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1160717003039 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1160717003040 Walker A motif; other site 1160717003041 ATP binding site [chemical binding]; other site 1160717003042 Walker B motif; other site 1160717003043 DNA binding loops [nucleotide binding] 1160717003044 NinB protein; Region: NinB; pfam05772 1160717003045 NINE Protein; Region: NinE; pfam05322 1160717003046 hypothetical protein; Region: PHA01519 1160717003047 NinF protein; Region: NinF; pfam05810 1160717003048 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1160717003049 Phage NinH protein; Region: Phage_NinH; pfam06322 1160717003050 Antitermination protein; Region: Antiterm; pfam03589 1160717003051 Antitermination protein; Region: Antiterm; pfam03589 1160717003052 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1160717003053 catalytic residues [active] 1160717003054 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1160717003055 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1160717003056 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1160717003057 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 1160717003058 hypothetical protein; Region: PHA00781 1160717003059 Terminase-like family; Region: Terminase_6; pfam03237 1160717003060 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1160717003061 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 1160717003062 coat protein; Region: PHA01511 1160717003063 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1160717003064 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 1160717003065 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 1160717003066 Protein of unknown function (DUF812); Region: DUF812; pfam05667 1160717003067 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 1160717003068 Arc-like DNA binding domain; Region: Arc; pfam03869 1160717003069 Head binding; Region: Head_binding; pfam09008 1160717003070 Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251 1160717003071 O-antigen conversion protein C; Region: PHA01514 1160717003072 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1160717003073 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1160717003074 Ligand binding site; other site 1160717003075 Putative Catalytic site; other site 1160717003076 DXD motif; other site 1160717003077 Predicted membrane protein [Function unknown]; Region: COG2246 1160717003078 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1160717003079 Integrase core domain; Region: rve; pfam00665 1160717003080 Integrase core domain; Region: rve_2; pfam13333 1160717003081 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1160717003082 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1160717003083 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1160717003084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003085 putative substrate translocation pore; other site 1160717003086 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1160717003087 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1160717003088 substrate binding site [chemical binding]; other site 1160717003089 ligand binding site [chemical binding]; other site 1160717003090 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 1160717003091 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1160717003092 hypothetical protein; Provisional; Region: PRK14812 1160717003093 substrate binding site [chemical binding]; other site 1160717003094 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1160717003095 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1160717003096 transcriptional activator TtdR; Provisional; Region: PRK09801 1160717003097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717003098 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1160717003099 putative effector binding pocket; other site 1160717003100 putative dimerization interface [polypeptide binding]; other site 1160717003101 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717003102 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717003103 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 1160717003104 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 1160717003105 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717003106 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717003107 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717003108 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717003109 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717003110 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1160717003111 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1160717003112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717003113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1160717003114 DNA binding site [nucleotide binding] 1160717003115 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1160717003116 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1160717003117 DNA binding residues [nucleotide binding] 1160717003118 dimerization interface [polypeptide binding]; other site 1160717003119 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1160717003120 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1160717003121 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1160717003122 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1160717003123 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717003124 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717003125 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1160717003126 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1160717003127 metal-binding site [ion binding] 1160717003128 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1160717003129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717003130 motif II; other site 1160717003131 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1160717003132 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1160717003133 DNA binding residues [nucleotide binding] 1160717003134 dimer interface [polypeptide binding]; other site 1160717003135 copper binding site [ion binding]; other site 1160717003136 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1160717003137 metal-binding site [ion binding] 1160717003138 putative sialic acid transporter; Region: 2A0112; TIGR00891 1160717003139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003140 putative substrate translocation pore; other site 1160717003141 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1160717003142 DNA methylase; Region: N6_N4_Mtase; cl17433 1160717003143 DNA methylase; Region: N6_N4_Mtase; pfam01555 1160717003144 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1160717003145 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1160717003146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1160717003147 VRR-NUC domain; Region: VRR_NUC; pfam08774 1160717003148 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1160717003149 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1160717003150 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1160717003151 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1160717003152 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717003153 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1160717003154 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1160717003155 N-terminal plug; other site 1160717003156 ligand-binding site [chemical binding]; other site 1160717003157 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1160717003158 hypothetical protein; Provisional; Region: PRK09929 1160717003159 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1160717003160 Propionate catabolism activator; Region: PrpR_N; pfam06506 1160717003161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717003162 Walker A motif; other site 1160717003163 ATP binding site [chemical binding]; other site 1160717003164 Walker B motif; other site 1160717003165 arginine finger; other site 1160717003166 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1160717003167 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1160717003168 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1160717003169 tetramer interface [polypeptide binding]; other site 1160717003170 active site 1160717003171 Mg2+/Mn2+ binding site [ion binding]; other site 1160717003172 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1160717003173 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1160717003174 dimer interface [polypeptide binding]; other site 1160717003175 active site 1160717003176 citrylCoA binding site [chemical binding]; other site 1160717003177 oxalacetate/citrate binding site [chemical binding]; other site 1160717003178 coenzyme A binding site [chemical binding]; other site 1160717003179 catalytic triad [active] 1160717003180 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1160717003181 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1160717003182 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1160717003183 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1160717003184 acyl-activating enzyme (AAE) consensus motif; other site 1160717003185 AMP binding site [chemical binding]; other site 1160717003186 active site 1160717003187 CoA binding site [chemical binding]; other site 1160717003188 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1160717003189 dimer interface [polypeptide binding]; other site 1160717003190 active site 1160717003191 Schiff base residues; other site 1160717003192 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1160717003193 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1160717003194 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1160717003195 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1160717003196 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1160717003197 ligand binding site [chemical binding]; other site 1160717003198 flexible hinge region; other site 1160717003199 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1160717003200 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1160717003201 microcin B17 transporter; Reviewed; Region: PRK11098 1160717003202 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1160717003203 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1160717003204 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1160717003205 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1160717003206 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1160717003207 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1160717003208 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1160717003209 drug efflux system protein MdtG; Provisional; Region: PRK09874 1160717003210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003211 putative substrate translocation pore; other site 1160717003212 anti-RssB factor; Provisional; Region: PRK10244 1160717003213 hypothetical protein; Provisional; Region: PRK11505 1160717003214 psiF repeat; Region: PsiF_repeat; pfam07769 1160717003215 psiF repeat; Region: PsiF_repeat; pfam07769 1160717003216 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1160717003217 MASE2 domain; Region: MASE2; pfam05230 1160717003218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717003219 metal binding site [ion binding]; metal-binding site 1160717003220 active site 1160717003221 I-site; other site 1160717003222 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1160717003223 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1160717003224 hypothetical protein; Validated; Region: PRK00124 1160717003225 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1160717003226 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1160717003227 ADP binding site [chemical binding]; other site 1160717003228 magnesium binding site [ion binding]; other site 1160717003229 putative shikimate binding site; other site 1160717003230 hypothetical protein; Provisional; Region: PRK10380 1160717003231 hypothetical protein; Provisional; Region: PRK10481 1160717003232 hypothetical protein; Provisional; Region: PRK10579 1160717003233 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1160717003234 fructokinase; Reviewed; Region: PRK09557 1160717003235 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717003236 nucleotide binding site [chemical binding]; other site 1160717003237 MFS transport protein AraJ; Provisional; Region: PRK10091 1160717003238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003239 putative substrate translocation pore; other site 1160717003240 exonuclease subunit SbcC; Provisional; Region: PRK10246 1160717003241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717003242 Walker A/P-loop; other site 1160717003243 ATP binding site [chemical binding]; other site 1160717003244 Q-loop/lid; other site 1160717003245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717003246 ABC transporter signature motif; other site 1160717003247 Walker B; other site 1160717003248 D-loop; other site 1160717003249 H-loop/switch region; other site 1160717003250 exonuclease subunit SbcD; Provisional; Region: PRK10966 1160717003251 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1160717003252 active site 1160717003253 metal binding site [ion binding]; metal-binding site 1160717003254 DNA binding site [nucleotide binding] 1160717003255 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1160717003256 transcriptional regulator PhoB; Provisional; Region: PRK10161 1160717003257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717003258 active site 1160717003259 phosphorylation site [posttranslational modification] 1160717003260 intermolecular recognition site; other site 1160717003261 dimerization interface [polypeptide binding]; other site 1160717003262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717003263 DNA binding site [nucleotide binding] 1160717003264 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1160717003265 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1160717003266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717003267 putative active site [active] 1160717003268 heme pocket [chemical binding]; other site 1160717003269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717003270 dimer interface [polypeptide binding]; other site 1160717003271 phosphorylation site [posttranslational modification] 1160717003272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717003273 ATP binding site [chemical binding]; other site 1160717003274 Mg2+ binding site [ion binding]; other site 1160717003275 G-X-G motif; other site 1160717003276 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1160717003277 putative proline-specific permease; Provisional; Region: proY; PRK10580 1160717003278 maltodextrin glucosidase; Provisional; Region: PRK10785 1160717003279 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1160717003280 homodimer interface [polypeptide binding]; other site 1160717003281 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1160717003282 active site 1160717003283 homodimer interface [polypeptide binding]; other site 1160717003284 catalytic site [active] 1160717003285 peroxidase; Provisional; Region: PRK15000 1160717003286 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1160717003287 dimer interface [polypeptide binding]; other site 1160717003288 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1160717003289 catalytic triad [active] 1160717003290 peroxidatic and resolving cysteines [active] 1160717003291 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1160717003292 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1160717003293 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1160717003294 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1160717003295 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1160717003296 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1160717003297 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1160717003298 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1160717003299 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1160717003300 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1160717003301 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1160717003302 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1160717003303 Protein export membrane protein; Region: SecD_SecF; pfam02355 1160717003304 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1160717003305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1160717003306 Predicted transcriptional regulator [Transcription]; Region: COG2378 1160717003307 HTH domain; Region: HTH_11; pfam08279 1160717003308 WYL domain; Region: WYL; pfam13280 1160717003309 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1160717003310 active site 1160717003311 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1160717003312 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1160717003313 hypothetical protein; Provisional; Region: PRK11530 1160717003314 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1160717003315 ATP cone domain; Region: ATP-cone; pfam03477 1160717003316 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1160717003317 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1160717003318 catalytic motif [active] 1160717003319 Zn binding site [ion binding]; other site 1160717003320 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1160717003321 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1160717003322 homopentamer interface [polypeptide binding]; other site 1160717003323 active site 1160717003324 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1160717003325 putative RNA binding site [nucleotide binding]; other site 1160717003326 thiamine monophosphate kinase; Provisional; Region: PRK05731 1160717003327 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1160717003328 ATP binding site [chemical binding]; other site 1160717003329 dimerization interface [polypeptide binding]; other site 1160717003330 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1160717003331 tetramer interfaces [polypeptide binding]; other site 1160717003332 binuclear metal-binding site [ion binding]; other site 1160717003333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717003334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717003335 active site 1160717003336 catalytic tetrad [active] 1160717003337 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1160717003338 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1160717003339 TPP-binding site; other site 1160717003340 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1160717003341 PYR/PP interface [polypeptide binding]; other site 1160717003342 dimer interface [polypeptide binding]; other site 1160717003343 TPP binding site [chemical binding]; other site 1160717003344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1160717003345 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1160717003346 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1160717003347 substrate binding pocket [chemical binding]; other site 1160717003348 chain length determination region; other site 1160717003349 substrate-Mg2+ binding site; other site 1160717003350 catalytic residues [active] 1160717003351 aspartate-rich region 1; other site 1160717003352 active site lid residues [active] 1160717003353 aspartate-rich region 2; other site 1160717003354 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1160717003355 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1160717003356 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1160717003357 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1160717003358 Ligand Binding Site [chemical binding]; other site 1160717003359 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1160717003360 active site residue [active] 1160717003361 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1160717003362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717003363 dimer interface [polypeptide binding]; other site 1160717003364 conserved gate region; other site 1160717003365 putative PBP binding loops; other site 1160717003366 ABC-ATPase subunit interface; other site 1160717003367 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1160717003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717003369 dimer interface [polypeptide binding]; other site 1160717003370 conserved gate region; other site 1160717003371 putative PBP binding loops; other site 1160717003372 ABC-ATPase subunit interface; other site 1160717003373 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1160717003374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717003375 Walker A/P-loop; other site 1160717003376 ATP binding site [chemical binding]; other site 1160717003377 Q-loop/lid; other site 1160717003378 ABC transporter signature motif; other site 1160717003379 Walker B; other site 1160717003380 D-loop; other site 1160717003381 H-loop/switch region; other site 1160717003382 TOBE domain; Region: TOBE_2; pfam08402 1160717003383 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1160717003384 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1160717003385 transcriptional regulator protein; Region: phnR; TIGR03337 1160717003386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717003387 DNA-binding site [nucleotide binding]; DNA binding site 1160717003388 UTRA domain; Region: UTRA; pfam07702 1160717003389 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 1160717003390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717003391 catalytic residue [active] 1160717003392 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1160717003393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717003394 motif II; other site 1160717003395 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1160717003396 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1160717003397 conserved cys residue [active] 1160717003398 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1160717003399 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1160717003400 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1160717003401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1160717003402 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1160717003403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717003405 putative substrate translocation pore; other site 1160717003406 Sel1-like repeats; Region: SEL1; smart00671 1160717003407 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717003408 Sel1 repeat; Region: Sel1; pfam08238 1160717003409 Sel1-like repeats; Region: SEL1; smart00671 1160717003410 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717003411 Sel1-like repeats; Region: SEL1; smart00671 1160717003412 Sel1-like repeats; Region: SEL1; smart00671 1160717003413 Sel1-like repeats; Region: SEL1; smart00671 1160717003414 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1160717003415 UbiA prenyltransferase family; Region: UbiA; pfam01040 1160717003416 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1160717003417 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1160717003418 Subunit I/III interface [polypeptide binding]; other site 1160717003419 Subunit III/IV interface [polypeptide binding]; other site 1160717003420 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1160717003421 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1160717003422 D-pathway; other site 1160717003423 Putative ubiquinol binding site [chemical binding]; other site 1160717003424 Low-spin heme (heme b) binding site [chemical binding]; other site 1160717003425 Putative water exit pathway; other site 1160717003426 Binuclear center (heme o3/CuB) [ion binding]; other site 1160717003427 K-pathway; other site 1160717003428 Putative proton exit pathway; other site 1160717003429 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1160717003430 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1160717003431 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1160717003432 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1160717003433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003434 putative substrate translocation pore; other site 1160717003435 hypothetical protein; Provisional; Region: PRK11627 1160717003436 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1160717003437 transcriptional regulator BolA; Provisional; Region: PRK11628 1160717003438 trigger factor; Provisional; Region: tig; PRK01490 1160717003439 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1160717003440 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1160717003441 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1160717003442 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1160717003443 oligomer interface [polypeptide binding]; other site 1160717003444 active site residues [active] 1160717003445 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1160717003446 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1160717003447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717003448 Walker A motif; other site 1160717003449 ATP binding site [chemical binding]; other site 1160717003450 Walker B motif; other site 1160717003451 Iron permease FTR1 family; Region: FTR1; cl00475 1160717003452 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1160717003453 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1160717003454 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1160717003455 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1160717003456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717003457 Walker A motif; other site 1160717003458 ATP binding site [chemical binding]; other site 1160717003459 Walker B motif; other site 1160717003460 arginine finger; other site 1160717003461 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1160717003462 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1160717003463 IHF dimer interface [polypeptide binding]; other site 1160717003464 IHF - DNA interface [nucleotide binding]; other site 1160717003465 periplasmic folding chaperone; Provisional; Region: PRK10788 1160717003466 SurA N-terminal domain; Region: SurA_N_3; cl07813 1160717003467 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1160717003468 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1160717003469 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1160717003470 active site 1160717003471 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1160717003472 Ligand Binding Site [chemical binding]; other site 1160717003473 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1160717003474 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1160717003475 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1160717003476 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1160717003477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717003478 active site 1160717003479 motif I; other site 1160717003480 motif II; other site 1160717003481 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1160717003482 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1160717003483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717003484 catalytic residue [active] 1160717003485 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1160717003486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717003487 putative DNA binding site [nucleotide binding]; other site 1160717003488 putative Zn2+ binding site [ion binding]; other site 1160717003489 AsnC family; Region: AsnC_trans_reg; pfam01037 1160717003490 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1160717003491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717003492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717003493 Walker A/P-loop; other site 1160717003494 ATP binding site [chemical binding]; other site 1160717003495 Q-loop/lid; other site 1160717003496 ABC transporter signature motif; other site 1160717003497 Walker B; other site 1160717003498 D-loop; other site 1160717003499 H-loop/switch region; other site 1160717003500 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1160717003501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717003502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717003503 Walker A/P-loop; other site 1160717003504 ATP binding site [chemical binding]; other site 1160717003505 Q-loop/lid; other site 1160717003506 ABC transporter signature motif; other site 1160717003507 Walker B; other site 1160717003508 D-loop; other site 1160717003509 H-loop/switch region; other site 1160717003510 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1160717003511 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1160717003512 ammonium transporter; Provisional; Region: PRK10666 1160717003513 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1160717003514 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1160717003515 active site 1160717003516 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1160717003517 catalytic triad [active] 1160717003518 dimer interface [polypeptide binding]; other site 1160717003519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1160717003520 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1160717003521 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1160717003522 DNA binding site [nucleotide binding] 1160717003523 active site 1160717003524 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1160717003525 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1160717003526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717003527 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1160717003528 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1160717003529 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1160717003530 maltose O-acetyltransferase; Provisional; Region: PRK10092 1160717003531 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1160717003532 active site 1160717003533 substrate binding site [chemical binding]; other site 1160717003534 trimer interface [polypeptide binding]; other site 1160717003535 CoA binding site [chemical binding]; other site 1160717003536 gene expression modulator; Provisional; Region: PRK10945 1160717003537 Hha toxicity attenuator; Provisional; Region: PRK10667 1160717003538 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1160717003539 Protein export membrane protein; Region: SecD_SecF; cl14618 1160717003540 Protein export membrane protein; Region: SecD_SecF; cl14618 1160717003541 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1160717003542 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717003543 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1160717003544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717003545 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1160717003546 hypothetical protein; Provisional; Region: PRK11281 1160717003547 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1160717003548 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1160717003549 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717003550 potential frameshift: common BLAST hit: gi|379699699|ref|YP_005241427.1| putative transposase 1160717003551 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1160717003552 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1160717003553 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1160717003554 hypothetical protein; Provisional; Region: PRK11038 1160717003555 primosomal replication protein N''; Provisional; Region: PRK10093 1160717003556 hypothetical protein; Provisional; Region: PRK10527 1160717003557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717003558 active site 1160717003559 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1160717003560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717003561 Walker A motif; other site 1160717003562 ATP binding site [chemical binding]; other site 1160717003563 Walker B motif; other site 1160717003564 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1160717003565 arginine finger; other site 1160717003566 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1160717003567 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1160717003568 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1160717003569 hypothetical protein; Validated; Region: PRK00153 1160717003570 recombination protein RecR; Reviewed; Region: recR; PRK00076 1160717003571 RecR protein; Region: RecR; pfam02132 1160717003572 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1160717003573 putative active site [active] 1160717003574 putative metal-binding site [ion binding]; other site 1160717003575 tetramer interface [polypeptide binding]; other site 1160717003576 heat shock protein 90; Provisional; Region: PRK05218 1160717003577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717003578 ATP binding site [chemical binding]; other site 1160717003579 Mg2+ binding site [ion binding]; other site 1160717003580 G-X-G motif; other site 1160717003581 adenylate kinase; Reviewed; Region: adk; PRK00279 1160717003582 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1160717003583 AMP-binding site [chemical binding]; other site 1160717003584 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1160717003585 ferrochelatase; Reviewed; Region: hemH; PRK00035 1160717003586 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1160717003587 C-terminal domain interface [polypeptide binding]; other site 1160717003588 active site 1160717003589 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1160717003590 active site 1160717003591 N-terminal domain interface [polypeptide binding]; other site 1160717003592 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1160717003593 acetyl esterase; Provisional; Region: PRK10162 1160717003594 inosine/guanosine kinase; Provisional; Region: PRK15074 1160717003595 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717003596 putative cation:proton antiport protein; Provisional; Region: PRK10669 1160717003597 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1160717003598 TrkA-N domain; Region: TrkA_N; pfam02254 1160717003599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003600 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717003601 putative substrate translocation pore; other site 1160717003602 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1160717003603 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1160717003604 active site 1160717003605 metal binding site [ion binding]; metal-binding site 1160717003606 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1160717003607 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1160717003608 putative deacylase active site [active] 1160717003609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1160717003610 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1160717003611 copper exporting ATPase; Provisional; Region: copA; PRK10671 1160717003612 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1160717003613 metal-binding site [ion binding] 1160717003614 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1160717003615 metal-binding site [ion binding] 1160717003616 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1160717003617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717003618 motif II; other site 1160717003619 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1160717003620 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1160717003621 DNA binding residues [nucleotide binding] 1160717003622 dimer interface [polypeptide binding]; other site 1160717003623 copper binding site [ion binding]; other site 1160717003624 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1160717003625 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1160717003626 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1160717003627 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1160717003628 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1160717003629 Walker A/P-loop; other site 1160717003630 ATP binding site [chemical binding]; other site 1160717003631 Q-loop/lid; other site 1160717003632 ABC transporter signature motif; other site 1160717003633 Walker B; other site 1160717003634 D-loop; other site 1160717003635 H-loop/switch region; other site 1160717003636 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1160717003637 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1160717003638 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1160717003639 oxidoreductase; Provisional; Region: PRK08017 1160717003640 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1160717003641 NADP binding site [chemical binding]; other site 1160717003642 active site 1160717003643 steroid binding site; other site 1160717003644 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1160717003645 active site 1160717003646 catalytic triad [active] 1160717003647 oxyanion hole [active] 1160717003648 switch loop; other site 1160717003649 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1160717003650 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1160717003651 Walker A/P-loop; other site 1160717003652 ATP binding site [chemical binding]; other site 1160717003653 Q-loop/lid; other site 1160717003654 ABC transporter signature motif; other site 1160717003655 Walker B; other site 1160717003656 D-loop; other site 1160717003657 H-loop/switch region; other site 1160717003658 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1160717003659 FtsX-like permease family; Region: FtsX; pfam02687 1160717003660 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717003661 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1160717003662 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1160717003663 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1160717003664 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1160717003665 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1160717003666 Walker A/P-loop; other site 1160717003667 ATP binding site [chemical binding]; other site 1160717003668 Q-loop/lid; other site 1160717003669 ABC transporter signature motif; other site 1160717003670 Walker B; other site 1160717003671 D-loop; other site 1160717003672 H-loop/switch region; other site 1160717003673 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1160717003674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717003675 dimer interface [polypeptide binding]; other site 1160717003676 conserved gate region; other site 1160717003677 ABC-ATPase subunit interface; other site 1160717003678 Predicted ATPase [General function prediction only]; Region: COG2603 1160717003679 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1160717003680 active site residue [active] 1160717003681 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1160717003682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717003683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717003684 dimerization interface [polypeptide binding]; other site 1160717003685 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1160717003686 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1160717003687 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1160717003688 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1160717003689 Bacterial transcriptional regulator; Region: IclR; pfam01614 1160717003690 glyoxylate carboligase; Provisional; Region: PRK11269 1160717003691 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1160717003692 PYR/PP interface [polypeptide binding]; other site 1160717003693 dimer interface [polypeptide binding]; other site 1160717003694 TPP binding site [chemical binding]; other site 1160717003695 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1160717003696 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1160717003697 TPP-binding site [chemical binding]; other site 1160717003698 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1160717003699 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1160717003700 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1160717003701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717003703 putative substrate translocation pore; other site 1160717003704 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1160717003705 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1160717003706 Na binding site [ion binding]; other site 1160717003707 putative substrate binding site [chemical binding]; other site 1160717003708 allantoinase; Provisional; Region: PRK08044 1160717003709 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1160717003710 active site 1160717003711 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1160717003712 glycerate kinase II; Provisional; Region: PRK09932 1160717003713 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1160717003714 Mif2/CENP-C like; Region: Mif2; pfam11699 1160717003715 Cupin domain; Region: Cupin_2; pfam07883 1160717003716 allantoate amidohydrolase; Region: AllC; TIGR03176 1160717003717 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1160717003718 active site 1160717003719 metal binding site [ion binding]; metal-binding site 1160717003720 dimer interface [polypeptide binding]; other site 1160717003721 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1160717003722 membrane protein FdrA; Validated; Region: PRK06091 1160717003723 CoA binding domain; Region: CoA_binding; pfam02629 1160717003724 CoA-ligase; Region: Ligase_CoA; pfam00549 1160717003725 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1160717003726 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1160717003727 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1160717003728 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1160717003729 putative substrate binding site [chemical binding]; other site 1160717003730 nucleotide binding site [chemical binding]; other site 1160717003731 nucleotide binding site [chemical binding]; other site 1160717003732 homodimer interface [polypeptide binding]; other site 1160717003733 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1160717003734 ATP-grasp domain; Region: ATP-grasp; pfam02222 1160717003735 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1160717003736 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1160717003737 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1160717003738 putative active site [active] 1160717003739 putative metal binding site [ion binding]; other site 1160717003740 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1160717003741 substrate binding site [chemical binding]; other site 1160717003742 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1160717003743 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1160717003744 active site 1160717003745 HIGH motif; other site 1160717003746 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1160717003747 KMSKS motif; other site 1160717003748 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1160717003749 tRNA binding surface [nucleotide binding]; other site 1160717003750 anticodon binding site; other site 1160717003751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 1160717003752 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 1160717003753 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1160717003754 ribosome-associated protein; Provisional; Region: PRK11507 1160717003755 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1160717003756 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1160717003757 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1160717003758 homodimer interface [polypeptide binding]; other site 1160717003759 NADP binding site [chemical binding]; other site 1160717003760 substrate binding site [chemical binding]; other site 1160717003761 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1160717003762 fimbrial protein FimI; Provisional; Region: PRK15200 1160717003763 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1160717003764 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717003765 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717003766 genomic island 1160717003767 outer membrane usher protein FimD; Provisional; Region: PRK15198 1160717003768 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717003769 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717003770 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717003771 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1160717003772 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1160717003773 transcriptional regulator FimZ; Provisional; Region: PRK09935 1160717003774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717003775 active site 1160717003776 phosphorylation site [posttranslational modification] 1160717003777 intermolecular recognition site; other site 1160717003778 dimerization interface [polypeptide binding]; other site 1160717003779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717003780 DNA binding residues [nucleotide binding] 1160717003781 dimerization interface [polypeptide binding]; other site 1160717003782 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 1160717003783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717003784 DNA binding residues [nucleotide binding] 1160717003785 dimerization interface [polypeptide binding]; other site 1160717003786 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1160717003787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1160717003788 Transposase; Region: HTH_Tnp_1; pfam01527 1160717003789 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1160717003790 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1160717003791 Ligand binding site; other site 1160717003792 Putative Catalytic site; other site 1160717003793 DXD motif; other site 1160717003794 Predicted membrane protein [Function unknown]; Region: COG2246 1160717003795 GtrA-like protein; Region: GtrA; pfam04138 1160717003796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717003797 ATP binding site [chemical binding]; other site 1160717003798 Mg2+ binding site [ion binding]; other site 1160717003799 G-X-G motif; other site 1160717003800 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1160717003801 Cupin; Region: Cupin_6; pfam12852 1160717003802 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1160717003803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717003804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717003805 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1160717003806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717003807 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1160717003808 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717003809 Predicted membrane protein [Function unknown]; Region: COG3059 1160717003810 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1160717003811 phenylalanine transporter; Provisional; Region: PRK10249 1160717003812 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1160717003813 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717003814 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1160717003815 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1160717003816 active site 1160717003817 oxyanion hole [active] 1160717003818 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1160717003819 catalytic triad [active] 1160717003820 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1160717003821 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1160717003822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717003823 ATP binding site [chemical binding]; other site 1160717003824 Walker B motif; other site 1160717003825 arginine finger; other site 1160717003826 Transcriptional antiterminator [Transcription]; Region: COG3933 1160717003827 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717003828 active pocket/dimerization site; other site 1160717003829 active site 1160717003830 phosphorylation site [posttranslational modification] 1160717003831 PRD domain; Region: PRD; pfam00874 1160717003832 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1160717003833 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1160717003834 putative active site [active] 1160717003835 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1160717003836 dimer interface [polypeptide binding]; other site 1160717003837 active site 1160717003838 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1160717003839 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1160717003840 dimer interface [polypeptide binding]; other site 1160717003841 active site 1160717003842 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1160717003843 dimer interface [polypeptide binding]; other site 1160717003844 active site 1160717003845 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1160717003846 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1160717003847 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1160717003848 active site 1160717003849 phosphorylation site [posttranslational modification] 1160717003850 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717003851 active pocket/dimerization site; other site 1160717003852 active site 1160717003853 phosphorylation site [posttranslational modification] 1160717003854 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1160717003855 dimer interface [polypeptide binding]; other site 1160717003856 FMN binding site [chemical binding]; other site 1160717003857 hypothetical protein; Provisional; Region: PRK10250 1160717003858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1160717003859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717003860 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1160717003861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717003862 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1160717003863 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1160717003864 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1160717003865 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1160717003866 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1160717003867 outer membrane receptor FepA; Provisional; Region: PRK13524 1160717003868 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1160717003869 N-terminal plug; other site 1160717003870 ligand-binding site [chemical binding]; other site 1160717003871 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1160717003872 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1160717003873 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1160717003874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1160717003875 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1160717003876 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1160717003877 acyl-activating enzyme (AAE) consensus motif; other site 1160717003878 AMP binding site [chemical binding]; other site 1160717003879 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1160717003880 LPS O-antigen length regulator; Provisional; Region: PRK10381 1160717003881 Chain length determinant protein; Region: Wzz; pfam02706 1160717003882 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1160717003883 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1160717003884 Walker A/P-loop; other site 1160717003885 ATP binding site [chemical binding]; other site 1160717003886 Q-loop/lid; other site 1160717003887 ABC transporter signature motif; other site 1160717003888 Walker B; other site 1160717003889 D-loop; other site 1160717003890 H-loop/switch region; other site 1160717003891 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1160717003892 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717003893 ABC-ATPase subunit interface; other site 1160717003894 dimer interface [polypeptide binding]; other site 1160717003895 putative PBP binding regions; other site 1160717003896 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1160717003897 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717003898 ABC-ATPase subunit interface; other site 1160717003899 dimer interface [polypeptide binding]; other site 1160717003900 putative PBP binding regions; other site 1160717003901 enterobactin exporter EntS; Provisional; Region: PRK10489 1160717003902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717003903 putative substrate translocation pore; other site 1160717003904 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1160717003905 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1160717003906 siderophore binding site; other site 1160717003907 isochorismate synthase EntC; Provisional; Region: PRK15016 1160717003908 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1160717003909 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1160717003910 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1160717003911 acyl-activating enzyme (AAE) consensus motif; other site 1160717003912 active site 1160717003913 AMP binding site [chemical binding]; other site 1160717003914 substrate binding site [chemical binding]; other site 1160717003915 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1160717003916 hydrophobic substrate binding pocket; other site 1160717003917 Isochorismatase family; Region: Isochorismatase; pfam00857 1160717003918 active site 1160717003919 conserved cis-peptide bond; other site 1160717003920 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1160717003921 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1160717003922 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1160717003923 putative NAD(P) binding site [chemical binding]; other site 1160717003924 active site 1160717003925 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1160717003926 CoenzymeA binding site [chemical binding]; other site 1160717003927 subunit interaction site [polypeptide binding]; other site 1160717003928 PHB binding site; other site 1160717003929 carbon starvation protein A; Provisional; Region: PRK15015 1160717003930 Carbon starvation protein CstA; Region: CstA; pfam02554 1160717003931 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1160717003932 Uncharacterized small protein [Function unknown]; Region: COG2879 1160717003933 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1160717003934 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1160717003935 putative active site [active] 1160717003936 metal binding site [ion binding]; metal-binding site 1160717003937 methionine aminotransferase; Validated; Region: PRK09082 1160717003938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717003939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717003940 homodimer interface [polypeptide binding]; other site 1160717003941 catalytic residue [active] 1160717003942 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1160717003943 ParB-like nuclease domain; Region: ParBc; pfam02195 1160717003944 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1160717003945 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1160717003946 Active Sites [active] 1160717003947 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1160717003948 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1160717003949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717003950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717003951 dimerization interface [polypeptide binding]; other site 1160717003952 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1160717003953 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1160717003954 catalytic residue [active] 1160717003955 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1160717003956 catalytic residues [active] 1160717003957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717003958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717003959 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1160717003960 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1160717003961 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1160717003962 putative [4Fe-4S] binding site [ion binding]; other site 1160717003963 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717003964 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1160717003965 molybdopterin cofactor binding site; other site 1160717003966 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1160717003967 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1160717003968 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1160717003969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1160717003970 Ligand Binding Site [chemical binding]; other site 1160717003971 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1160717003972 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1160717003973 NAD binding site [chemical binding]; other site 1160717003974 catalytic Zn binding site [ion binding]; other site 1160717003975 structural Zn binding site [ion binding]; other site 1160717003976 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1160717003977 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1160717003978 rnk_leader; SU4_nc43 1160717003979 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1160717003980 B1 nucleotide binding pocket [chemical binding]; other site 1160717003981 B2 nucleotide binding pocket [chemical binding]; other site 1160717003982 CAS motifs; other site 1160717003983 active site 1160717003984 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1160717003985 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1160717003986 transmembrane helices; other site 1160717003987 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1160717003988 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1160717003989 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1160717003990 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1160717003991 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1160717003992 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1160717003993 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1160717003994 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1160717003995 putative active site [active] 1160717003996 (T/H)XGH motif; other site 1160717003997 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1160717003998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717003999 putative active site [active] 1160717004000 heme pocket [chemical binding]; other site 1160717004001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717004002 ATP binding site [chemical binding]; other site 1160717004003 Mg2+ binding site [ion binding]; other site 1160717004004 G-X-G motif; other site 1160717004005 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1160717004006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717004007 active site 1160717004008 phosphorylation site [posttranslational modification] 1160717004009 intermolecular recognition site; other site 1160717004010 dimerization interface [polypeptide binding]; other site 1160717004011 Transcriptional regulator; Region: CitT; pfam12431 1160717004012 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1160717004013 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1160717004014 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1160717004015 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1160717004016 DNA-binding site [nucleotide binding]; DNA binding site 1160717004017 RNA-binding motif; other site 1160717004018 chromosome condensation membrane protein; Provisional; Region: PRK14196 1160717004019 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1160717004020 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1160717004021 putative active site [active] 1160717004022 catalytic triad [active] 1160717004023 putative dimer interface [polypeptide binding]; other site 1160717004024 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1160717004025 lipoyl synthase; Provisional; Region: PRK05481 1160717004026 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717004027 FeS/SAM binding site; other site 1160717004028 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1160717004029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717004030 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1160717004031 substrate binding pocket [chemical binding]; other site 1160717004032 dimerization interface [polypeptide binding]; other site 1160717004033 lipoate-protein ligase B; Provisional; Region: PRK14342 1160717004034 hypothetical protein; Provisional; Region: PRK04998 1160717004035 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1160717004036 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1160717004037 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1160717004038 rare lipoprotein A; Provisional; Region: PRK10672 1160717004039 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1160717004040 Sporulation related domain; Region: SPOR; pfam05036 1160717004041 cell wall shape-determining protein; Provisional; Region: PRK10794 1160717004042 penicillin-binding protein 2; Provisional; Region: PRK10795 1160717004043 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1160717004044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1160717004045 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1160717004046 Oligomerisation domain; Region: Oligomerisation; cl00519 1160717004047 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1160717004048 catalytic core [active] 1160717004049 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1160717004050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717004051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717004052 homodimer interface [polypeptide binding]; other site 1160717004053 catalytic residue [active] 1160717004054 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1160717004055 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1160717004056 active site 1160717004057 (T/H)XGH motif; other site 1160717004058 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1160717004059 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1160717004060 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1160717004061 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1160717004062 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1160717004063 HIGH motif; other site 1160717004064 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1160717004065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1160717004066 active site 1160717004067 KMSKS motif; other site 1160717004068 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1160717004069 tRNA binding surface [nucleotide binding]; other site 1160717004070 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1160717004071 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1160717004072 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1160717004073 Propionate catabolism activator; Region: PrpR_N; pfam06506 1160717004074 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1160717004075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717004076 Walker A motif; other site 1160717004077 ATP binding site [chemical binding]; other site 1160717004078 Walker B motif; other site 1160717004079 arginine finger; other site 1160717004080 hypothetical protein; Provisional; Region: PRK11032 1160717004081 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1160717004082 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717004083 Sel1-like repeats; Region: SEL1; smart00671 1160717004084 Sel1-like repeats; Region: SEL1; smart00671 1160717004085 Sel1-like repeats; Region: SEL1; smart00671 1160717004086 Sel1-like repeats; Region: SEL1; smart00671 1160717004087 Sel1-like repeats; Region: SEL1; smart00671 1160717004088 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1160717004089 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1160717004090 HSP70 interaction site [polypeptide binding]; other site 1160717004091 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1160717004092 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1160717004093 HSP70 interaction site [polypeptide binding]; other site 1160717004094 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1160717004095 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1160717004096 nucleotide binding site [chemical binding]; other site 1160717004097 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1160717004098 SBD interface [polypeptide binding]; other site 1160717004099 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1160717004100 active site 1160717004101 tetramer interface [polypeptide binding]; other site 1160717004102 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1160717004103 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1160717004104 Walker A/P-loop; other site 1160717004105 ATP binding site [chemical binding]; other site 1160717004106 Q-loop/lid; other site 1160717004107 ABC transporter signature motif; other site 1160717004108 Walker B; other site 1160717004109 D-loop; other site 1160717004110 H-loop/switch region; other site 1160717004111 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717004112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004113 dimer interface [polypeptide binding]; other site 1160717004114 conserved gate region; other site 1160717004115 putative PBP binding loops; other site 1160717004116 ABC-ATPase subunit interface; other site 1160717004117 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717004118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004119 dimer interface [polypeptide binding]; other site 1160717004120 conserved gate region; other site 1160717004121 putative PBP binding loops; other site 1160717004122 ABC-ATPase subunit interface; other site 1160717004123 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1160717004124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717004125 substrate binding pocket [chemical binding]; other site 1160717004126 membrane-bound complex binding site; other site 1160717004127 hinge residues; other site 1160717004128 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1160717004129 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1160717004130 putative active site [active] 1160717004131 catalytic triad [active] 1160717004132 putative dimer interface [polypeptide binding]; other site 1160717004133 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1160717004134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1160717004135 Transporter associated domain; Region: CorC_HlyC; smart01091 1160717004136 metal-binding heat shock protein; Provisional; Region: PRK00016 1160717004137 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1160717004138 PhoH-like protein; Region: PhoH; pfam02562 1160717004139 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1160717004140 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1160717004141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717004142 FeS/SAM binding site; other site 1160717004143 TRAM domain; Region: TRAM; pfam01938 1160717004144 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1160717004145 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1160717004146 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1160717004147 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1160717004148 active site 1160717004149 dimer interface [polypeptide binding]; other site 1160717004150 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1160717004151 Ligand Binding Site [chemical binding]; other site 1160717004152 Molecular Tunnel; other site 1160717004153 UMP phosphatase; Provisional; Region: PRK10444 1160717004154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004155 active site 1160717004156 motif I; other site 1160717004157 motif II; other site 1160717004158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004159 MarR family; Region: MarR; pfam01047 1160717004160 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1160717004161 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717004162 nucleotide binding site [chemical binding]; other site 1160717004163 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1160717004164 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1160717004165 active site 1160717004166 dimer interface [polypeptide binding]; other site 1160717004167 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1160717004168 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1160717004169 active site 1160717004170 trimer interface [polypeptide binding]; other site 1160717004171 allosteric site; other site 1160717004172 active site lid [active] 1160717004173 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1160717004174 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1160717004175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1160717004176 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1160717004177 active site turn [active] 1160717004178 phosphorylation site [posttranslational modification] 1160717004179 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1160717004180 HPr interaction site; other site 1160717004181 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1160717004182 active site 1160717004183 phosphorylation site [posttranslational modification] 1160717004184 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1160717004185 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1160717004186 active site 1160717004187 HIGH motif; other site 1160717004188 nucleotide binding site [chemical binding]; other site 1160717004189 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1160717004190 KMSKS motif; other site 1160717004191 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1160717004192 outer membrane porin, OprD family; Region: OprD; pfam03573 1160717004193 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1160717004194 YbfN-like lipoprotein; Region: YbfN; pfam13982 1160717004195 citrate-proton symporter; Provisional; Region: PRK15075 1160717004196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717004197 putative substrate translocation pore; other site 1160717004198 tricarballylate utilization protein B; Provisional; Region: PRK15033 1160717004199 tricarballylate dehydrogenase; Validated; Region: PRK08274 1160717004200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717004201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717004202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717004203 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1160717004204 putative dimerization interface [polypeptide binding]; other site 1160717004205 ferric uptake regulator; Provisional; Region: fur; PRK09462 1160717004206 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1160717004207 metal binding site 2 [ion binding]; metal-binding site 1160717004208 putative DNA binding helix; other site 1160717004209 metal binding site 1 [ion binding]; metal-binding site 1160717004210 dimer interface [polypeptide binding]; other site 1160717004211 structural Zn2+ binding site [ion binding]; other site 1160717004212 flavodoxin FldA; Validated; Region: PRK09267 1160717004213 LexA regulated protein; Provisional; Region: PRK11675 1160717004214 acyl-CoA esterase; Provisional; Region: PRK10673 1160717004215 PGAP1-like protein; Region: PGAP1; pfam07819 1160717004216 replication initiation regulator SeqA; Provisional; Region: PRK11187 1160717004217 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1160717004218 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1160717004219 active site 1160717004220 substrate binding site [chemical binding]; other site 1160717004221 metal binding site [ion binding]; metal-binding site 1160717004222 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1160717004223 putrescine transporter; Provisional; Region: potE; PRK10655 1160717004224 ornithine decarboxylase; Provisional; Region: PRK13578 1160717004225 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1160717004226 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1160717004227 homodimer interface [polypeptide binding]; other site 1160717004228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717004229 catalytic residue [active] 1160717004230 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1160717004231 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1160717004232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717004233 active site 1160717004234 phosphorylation site [posttranslational modification] 1160717004235 intermolecular recognition site; other site 1160717004236 dimerization interface [polypeptide binding]; other site 1160717004237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717004238 DNA binding site [nucleotide binding] 1160717004239 sensor protein KdpD; Provisional; Region: PRK10490 1160717004240 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1160717004241 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1160717004242 Ligand Binding Site [chemical binding]; other site 1160717004243 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1160717004244 GAF domain; Region: GAF_3; pfam13492 1160717004245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717004246 dimer interface [polypeptide binding]; other site 1160717004247 phosphorylation site [posttranslational modification] 1160717004248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717004249 ATP binding site [chemical binding]; other site 1160717004250 Mg2+ binding site [ion binding]; other site 1160717004251 G-X-G motif; other site 1160717004252 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1160717004253 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1160717004254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1160717004255 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1160717004256 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1160717004257 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1160717004258 DNA photolyase; Region: DNA_photolyase; pfam00875 1160717004259 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1160717004260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717004261 putative substrate translocation pore; other site 1160717004262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717004263 genomic island 1160717004264 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1160717004265 metal-binding protein; Provisional; Region: PRK10799 1160717004266 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1160717004267 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1160717004268 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1160717004269 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1160717004270 putative active site [active] 1160717004271 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1160717004272 active site 1160717004273 DNA binding site [nucleotide binding] 1160717004274 Int/Topo IB signature motif; other site 1160717004275 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1160717004276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717004277 active site 1160717004278 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1160717004279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1160717004280 putative ADP-binding pocket [chemical binding]; other site 1160717004281 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1160717004282 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1160717004283 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1160717004284 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1160717004285 Walker A/P-loop; other site 1160717004286 ATP binding site [chemical binding]; other site 1160717004287 Q-loop/lid; other site 1160717004288 ABC transporter signature motif; other site 1160717004289 Walker B; other site 1160717004290 D-loop; other site 1160717004291 H-loop/switch region; other site 1160717004292 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1160717004293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717004294 active site 1160717004295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1160717004296 active site 1160717004297 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1160717004298 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1160717004299 endonuclease VIII; Provisional; Region: PRK10445 1160717004300 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1160717004301 DNA binding site [nucleotide binding] 1160717004302 catalytic residue [active] 1160717004303 putative catalytic residues [active] 1160717004304 H2TH interface [polypeptide binding]; other site 1160717004305 intercalation triad [nucleotide binding]; other site 1160717004306 substrate specificity determining residue; other site 1160717004307 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1160717004308 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1160717004309 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1160717004310 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1160717004311 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1160717004312 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1160717004313 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1160717004314 dimer interface [polypeptide binding]; other site 1160717004315 active site 1160717004316 citrylCoA binding site [chemical binding]; other site 1160717004317 NADH binding [chemical binding]; other site 1160717004318 cationic pore residues; other site 1160717004319 oxalacetate/citrate binding site [chemical binding]; other site 1160717004320 coenzyme A binding site [chemical binding]; other site 1160717004321 catalytic triad [active] 1160717004322 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1160717004323 Iron-sulfur protein interface; other site 1160717004324 proximal quinone binding site [chemical binding]; other site 1160717004325 SdhD (CybS) interface [polypeptide binding]; other site 1160717004326 proximal heme binding site [chemical binding]; other site 1160717004327 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1160717004328 SdhC subunit interface [polypeptide binding]; other site 1160717004329 proximal heme binding site [chemical binding]; other site 1160717004330 cardiolipin binding site; other site 1160717004331 Iron-sulfur protein interface; other site 1160717004332 proximal quinone binding site [chemical binding]; other site 1160717004333 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1160717004334 L-aspartate oxidase; Provisional; Region: PRK06175 1160717004335 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1160717004336 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1160717004337 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1160717004338 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1160717004339 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1160717004340 TPP-binding site [chemical binding]; other site 1160717004341 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1160717004342 dimer interface [polypeptide binding]; other site 1160717004343 PYR/PP interface [polypeptide binding]; other site 1160717004344 TPP binding site [chemical binding]; other site 1160717004345 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1160717004346 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1160717004347 E3 interaction surface; other site 1160717004348 lipoyl attachment site [posttranslational modification]; other site 1160717004349 e3 binding domain; Region: E3_binding; pfam02817 1160717004350 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1160717004351 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1160717004352 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1160717004353 CoA-ligase; Region: Ligase_CoA; pfam00549 1160717004354 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1160717004355 CoA binding domain; Region: CoA_binding; smart00881 1160717004356 CoA-ligase; Region: Ligase_CoA; pfam00549 1160717004357 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1160717004358 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1160717004359 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1160717004360 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1160717004361 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1160717004362 active site 1160717004363 colicin uptake protein TolQ; Provisional; Region: PRK10801 1160717004364 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1160717004365 colicin uptake protein TolR; Provisional; Region: PRK11024 1160717004366 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1160717004367 TolA C-terminal; Region: TolA; pfam06519 1160717004368 genomic island 1160717004369 translocation protein TolB; Provisional; Region: tolB; PRK03629 1160717004370 TolB amino-terminal domain; Region: TolB_N; pfam04052 1160717004371 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1160717004372 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1160717004373 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1160717004374 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1160717004375 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1160717004376 ligand binding site [chemical binding]; other site 1160717004377 tol-pal system protein YbgF; Provisional; Region: PRK10803 1160717004378 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1160717004379 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1160717004380 quinolinate synthetase; Provisional; Region: PRK09375 1160717004381 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1160717004382 zinc transporter ZitB; Provisional; Region: PRK03557 1160717004383 YbgS-like protein; Region: YbgS; pfam13985 1160717004384 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1160717004385 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1160717004386 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 1160717004387 fumarate hydratase; Provisional; Region: PRK06246 1160717004388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717004389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717004390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717004391 dimerization interface [polypeptide binding]; other site 1160717004392 cell density-dependent motility repressor; Provisional; Region: PRK10082 1160717004393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717004394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717004395 dimerization interface [polypeptide binding]; other site 1160717004396 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1160717004397 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1160717004398 transmembrane helices; other site 1160717004399 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1160717004400 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1160717004401 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1160717004402 active site 1160717004403 catalytic residues [active] 1160717004404 metal binding site [ion binding]; metal-binding site 1160717004405 homodimer binding site [polypeptide binding]; other site 1160717004406 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1160717004407 carboxyltransferase (CT) interaction site; other site 1160717004408 biotinylation site [posttranslational modification]; other site 1160717004409 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1160717004410 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1160717004411 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1160717004412 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717004413 dimer interface [polypeptide binding]; other site 1160717004414 putative PBP binding regions; other site 1160717004415 ABC-ATPase subunit interface; other site 1160717004416 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1160717004417 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1160717004418 Walker A/P-loop; other site 1160717004419 ATP binding site [chemical binding]; other site 1160717004420 Q-loop/lid; other site 1160717004421 ABC transporter signature motif; other site 1160717004422 Walker B; other site 1160717004423 D-loop; other site 1160717004424 H-loop/switch region; other site 1160717004425 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1160717004426 catalytic core [active] 1160717004427 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1160717004428 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1160717004429 active site 1160717004430 catalytic residues [active] 1160717004431 galactokinase; Provisional; Region: PRK05101 1160717004432 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1160717004433 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1160717004434 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1160717004435 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1160717004436 dimer interface [polypeptide binding]; other site 1160717004437 active site 1160717004438 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1160717004439 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1160717004440 NAD binding site [chemical binding]; other site 1160717004441 homodimer interface [polypeptide binding]; other site 1160717004442 active site 1160717004443 substrate binding site [chemical binding]; other site 1160717004444 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 1160717004445 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1160717004446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004447 Walker A/P-loop; other site 1160717004448 ATP binding site [chemical binding]; other site 1160717004449 Q-loop/lid; other site 1160717004450 ABC transporter signature motif; other site 1160717004451 Walker B; other site 1160717004452 D-loop; other site 1160717004453 H-loop/switch region; other site 1160717004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004455 Walker A/P-loop; other site 1160717004456 ATP binding site [chemical binding]; other site 1160717004457 Q-loop/lid; other site 1160717004458 ABC transporter signature motif; other site 1160717004459 Walker B; other site 1160717004460 D-loop; other site 1160717004461 H-loop/switch region; other site 1160717004462 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1160717004463 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1160717004464 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1160717004465 TOBE domain; Region: TOBE; pfam03459 1160717004466 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1160717004467 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1160717004468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717004469 substrate binding pocket [chemical binding]; other site 1160717004470 membrane-bound complex binding site; other site 1160717004471 hinge residues; other site 1160717004472 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1160717004473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004474 dimer interface [polypeptide binding]; other site 1160717004475 conserved gate region; other site 1160717004476 putative PBP binding loops; other site 1160717004477 ABC-ATPase subunit interface; other site 1160717004478 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1160717004479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004480 Walker A/P-loop; other site 1160717004481 ATP binding site [chemical binding]; other site 1160717004482 Q-loop/lid; other site 1160717004483 ABC transporter signature motif; other site 1160717004484 Walker B; other site 1160717004485 D-loop; other site 1160717004486 H-loop/switch region; other site 1160717004487 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1160717004488 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1160717004489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004490 active site 1160717004491 motif I; other site 1160717004492 motif II; other site 1160717004493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004494 6-phosphogluconolactonase; Provisional; Region: PRK11028 1160717004495 acyl-CoA thioesterase; Provisional; Region: PRK10531 1160717004496 putative pectinesterase; Region: PLN02432; cl01911 1160717004497 imidazolonepropionase; Validated; Region: PRK09356 1160717004498 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1160717004499 active site 1160717004500 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1160717004501 putative active site [active] 1160717004502 putative metal binding site [ion binding]; other site 1160717004503 histidine utilization repressor; Provisional; Region: PRK14999 1160717004504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717004505 DNA-binding site [nucleotide binding]; DNA binding site 1160717004506 UTRA domain; Region: UTRA; pfam07702 1160717004507 urocanate hydratase; Provisional; Region: PRK05414 1160717004508 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1160717004509 active sites [active] 1160717004510 tetramer interface [polypeptide binding]; other site 1160717004511 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1160717004512 substrate binding site [chemical binding]; other site 1160717004513 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1160717004514 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1160717004515 inhibitor-cofactor binding pocket; inhibition site 1160717004516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717004517 catalytic residue [active] 1160717004518 biotin synthase; Provisional; Region: PRK15108 1160717004519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717004520 FeS/SAM binding site; other site 1160717004521 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1160717004522 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1160717004523 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1160717004524 substrate-cofactor binding pocket; other site 1160717004525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717004526 catalytic residue [active] 1160717004527 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1160717004528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717004529 S-adenosylmethionine binding site [chemical binding]; other site 1160717004530 AAA domain; Region: AAA_26; pfam13500 1160717004531 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1160717004532 excinuclease ABC subunit B; Provisional; Region: PRK05298 1160717004533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717004534 ATP binding site [chemical binding]; other site 1160717004535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717004536 nucleotide binding region [chemical binding]; other site 1160717004537 ATP-binding site [chemical binding]; other site 1160717004538 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1160717004539 UvrB/uvrC motif; Region: UVR; pfam02151 1160717004540 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1160717004541 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1160717004542 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1160717004543 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1160717004544 Leucine-rich repeats; other site 1160717004545 Substrate binding site [chemical binding]; other site 1160717004546 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1160717004547 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1160717004548 putative substrate binding pocket [chemical binding]; other site 1160717004549 dimer interface [polypeptide binding]; other site 1160717004550 phosphate binding site [ion binding]; other site 1160717004551 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1160717004552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717004553 FeS/SAM binding site; other site 1160717004554 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1160717004555 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1160717004556 MPT binding site; other site 1160717004557 trimer interface [polypeptide binding]; other site 1160717004558 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1160717004559 trimer interface [polypeptide binding]; other site 1160717004560 dimer interface [polypeptide binding]; other site 1160717004561 putative active site [active] 1160717004562 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1160717004563 MoaE interaction surface [polypeptide binding]; other site 1160717004564 MoeB interaction surface [polypeptide binding]; other site 1160717004565 thiocarboxylated glycine; other site 1160717004566 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1160717004567 MoaE homodimer interface [polypeptide binding]; other site 1160717004568 MoaD interaction [polypeptide binding]; other site 1160717004569 active site residues [active] 1160717004570 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1160717004571 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1160717004572 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1160717004573 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1160717004574 Predicted integral membrane protein [Function unknown]; Region: COG0392 1160717004575 cardiolipin synthase 2; Provisional; Region: PRK11263 1160717004576 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1160717004577 putative active site [active] 1160717004578 catalytic site [active] 1160717004579 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1160717004580 putative active site [active] 1160717004581 catalytic site [active] 1160717004582 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1160717004583 putative catalytic site [active] 1160717004584 putative metal binding site [ion binding]; other site 1160717004585 putative phosphate binding site [ion binding]; other site 1160717004586 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1160717004587 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1160717004588 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1160717004589 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1160717004590 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1160717004591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1160717004592 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1160717004593 Walker A/P-loop; other site 1160717004594 ATP binding site [chemical binding]; other site 1160717004595 Q-loop/lid; other site 1160717004596 ABC transporter signature motif; other site 1160717004597 Walker B; other site 1160717004598 D-loop; other site 1160717004599 H-loop/switch region; other site 1160717004600 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1160717004601 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1160717004602 Walker A/P-loop; other site 1160717004603 ATP binding site [chemical binding]; other site 1160717004604 Q-loop/lid; other site 1160717004605 ABC transporter signature motif; other site 1160717004606 Walker B; other site 1160717004607 D-loop; other site 1160717004608 H-loop/switch region; other site 1160717004609 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1160717004610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717004611 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717004612 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1160717004613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717004614 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1160717004615 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1160717004616 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1160717004617 ATP binding site [chemical binding]; other site 1160717004618 Mg++ binding site [ion binding]; other site 1160717004619 motif III; other site 1160717004620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717004621 nucleotide binding region [chemical binding]; other site 1160717004622 ATP-binding site [chemical binding]; other site 1160717004623 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1160717004624 DEAD_2; Region: DEAD_2; pfam06733 1160717004625 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1160717004626 glycosyl transferase family protein; Provisional; Region: PRK08136 1160717004627 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1160717004628 hypothetical protein; Provisional; Region: PRK10259 1160717004629 hypothetical protein; Provisional; Region: PRK11019 1160717004630 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1160717004631 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1160717004632 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1160717004633 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717004634 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1160717004635 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1160717004636 Walker A/P-loop; other site 1160717004637 ATP binding site [chemical binding]; other site 1160717004638 Q-loop/lid; other site 1160717004639 ABC transporter signature motif; other site 1160717004640 Walker B; other site 1160717004641 D-loop; other site 1160717004642 H-loop/switch region; other site 1160717004643 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717004644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004645 dimer interface [polypeptide binding]; other site 1160717004646 conserved gate region; other site 1160717004647 putative PBP binding loops; other site 1160717004648 ABC-ATPase subunit interface; other site 1160717004649 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1160717004650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717004651 substrate binding pocket [chemical binding]; other site 1160717004652 membrane-bound complex binding site; other site 1160717004653 hinge residues; other site 1160717004654 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1160717004655 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1160717004656 dimerization interface [polypeptide binding]; other site 1160717004657 DPS ferroxidase diiron center [ion binding]; other site 1160717004658 ion pore; other site 1160717004659 threonine and homoserine efflux system; Provisional; Region: PRK10532 1160717004660 EamA-like transporter family; Region: EamA; pfam00892 1160717004661 outer membrane protein X; Provisional; Region: ompX; PRK09408 1160717004662 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1160717004663 Sulfatase; Region: Sulfatase; pfam00884 1160717004664 manganese transport regulator MntR; Provisional; Region: PRK11050 1160717004665 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1160717004666 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1160717004667 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1160717004668 transmembrane helices; other site 1160717004669 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1160717004670 L,D-transpeptidase; Provisional; Region: PRK10260 1160717004671 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717004672 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1160717004673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717004674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004675 Walker A/P-loop; other site 1160717004676 ATP binding site [chemical binding]; other site 1160717004677 ABC transporter signature motif; other site 1160717004678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717004679 Walker B; other site 1160717004680 ABC transporter; Region: ABC_tran_2; pfam12848 1160717004681 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717004682 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1160717004683 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1160717004684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004685 active site 1160717004686 motif I; other site 1160717004687 motif II; other site 1160717004688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004689 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1160717004690 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1160717004691 dimer interface [polypeptide binding]; other site 1160717004692 active site 1160717004693 glycine loop; other site 1160717004694 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1160717004695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717004696 FeS/SAM binding site; other site 1160717004697 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1160717004698 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1160717004699 ATP binding site [chemical binding]; other site 1160717004700 substrate interface [chemical binding]; other site 1160717004701 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1160717004702 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1160717004703 dimer interface [polypeptide binding]; other site 1160717004704 putative functional site; other site 1160717004705 putative MPT binding site; other site 1160717004706 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1160717004707 catalytic nucleophile [active] 1160717004708 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1160717004709 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717004710 Walker A/P-loop; other site 1160717004711 ATP binding site [chemical binding]; other site 1160717004712 Q-loop/lid; other site 1160717004713 ABC transporter signature motif; other site 1160717004714 Walker B; other site 1160717004715 D-loop; other site 1160717004716 H-loop/switch region; other site 1160717004717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1160717004718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717004719 Walker A/P-loop; other site 1160717004720 ATP binding site [chemical binding]; other site 1160717004721 Q-loop/lid; other site 1160717004722 ABC transporter signature motif; other site 1160717004723 Walker B; other site 1160717004724 D-loop; other site 1160717004725 H-loop/switch region; other site 1160717004726 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1160717004727 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1160717004728 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1160717004729 genomic island 1160717004730 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1160717004731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004732 dimer interface [polypeptide binding]; other site 1160717004733 conserved gate region; other site 1160717004734 putative PBP binding loops; other site 1160717004735 ABC-ATPase subunit interface; other site 1160717004736 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1160717004737 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1160717004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004739 dimer interface [polypeptide binding]; other site 1160717004740 conserved gate region; other site 1160717004741 putative PBP binding loops; other site 1160717004742 ABC-ATPase subunit interface; other site 1160717004743 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1160717004744 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1160717004745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717004746 FeS/SAM binding site; other site 1160717004747 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1160717004748 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1160717004749 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1160717004750 Ligand binding site [chemical binding]; other site 1160717004751 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1160717004752 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1160717004753 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1160717004754 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1160717004755 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1160717004756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1160717004757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1160717004758 active site 1160717004759 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1160717004760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717004761 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1160717004762 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1160717004763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717004764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717004765 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1160717004766 putative dimerization interface [polypeptide binding]; other site 1160717004767 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1160717004768 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1160717004769 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1160717004770 putative C-terminal domain interface [polypeptide binding]; other site 1160717004771 putative GSH binding site (G-site) [chemical binding]; other site 1160717004772 putative dimer interface [polypeptide binding]; other site 1160717004773 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1160717004774 putative N-terminal domain interface [polypeptide binding]; other site 1160717004775 putative dimer interface [polypeptide binding]; other site 1160717004776 putative substrate binding pocket (H-site) [chemical binding]; other site 1160717004777 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1160717004778 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1160717004779 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1160717004780 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1160717004781 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1160717004782 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717004783 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1160717004784 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1160717004785 active site 1160717004786 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1160717004787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717004788 putative substrate translocation pore; other site 1160717004789 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1160717004790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004791 active site 1160717004792 motif I; other site 1160717004793 motif II; other site 1160717004794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717004795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717004796 putative substrate translocation pore; other site 1160717004797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717004798 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1160717004799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717004800 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1160717004801 putative transporter; Provisional; Region: PRK04972 1160717004802 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1160717004803 TrkA-C domain; Region: TrkA_C; pfam02080 1160717004804 TrkA-C domain; Region: TrkA_C; pfam02080 1160717004805 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1160717004806 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1160717004807 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1160717004808 GSH binding site [chemical binding]; other site 1160717004809 catalytic residues [active] 1160717004810 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1160717004811 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1160717004812 dimer interface [polypeptide binding]; other site 1160717004813 FMN binding site [chemical binding]; other site 1160717004814 NADPH bind site [chemical binding]; other site 1160717004815 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1160717004816 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1160717004817 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1160717004818 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1160717004819 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1160717004820 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1160717004821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004822 Walker A/P-loop; other site 1160717004823 ATP binding site [chemical binding]; other site 1160717004824 Q-loop/lid; other site 1160717004825 ABC transporter signature motif; other site 1160717004826 Walker B; other site 1160717004827 D-loop; other site 1160717004828 H-loop/switch region; other site 1160717004829 TOBE domain; Region: TOBE_2; pfam08402 1160717004830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004831 dimer interface [polypeptide binding]; other site 1160717004832 conserved gate region; other site 1160717004833 putative PBP binding loops; other site 1160717004834 ABC-ATPase subunit interface; other site 1160717004835 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1160717004836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004837 dimer interface [polypeptide binding]; other site 1160717004838 conserved gate region; other site 1160717004839 putative PBP binding loops; other site 1160717004840 ABC-ATPase subunit interface; other site 1160717004841 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1160717004842 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1160717004843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717004844 S-adenosylmethionine binding site [chemical binding]; other site 1160717004845 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1160717004846 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1160717004847 active site 1160717004848 P-loop; other site 1160717004849 phosphorylation site [posttranslational modification] 1160717004850 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1160717004851 Sulfatase; Region: Sulfatase; cl17466 1160717004852 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1160717004853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717004854 substrate binding pocket [chemical binding]; other site 1160717004855 membrane-bound complex binding site; other site 1160717004856 hinge residues; other site 1160717004857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004858 dimer interface [polypeptide binding]; other site 1160717004859 conserved gate region; other site 1160717004860 putative PBP binding loops; other site 1160717004861 ABC-ATPase subunit interface; other site 1160717004862 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717004864 dimer interface [polypeptide binding]; other site 1160717004865 conserved gate region; other site 1160717004866 putative PBP binding loops; other site 1160717004867 ABC-ATPase subunit interface; other site 1160717004868 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1160717004869 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717004870 substrate binding pocket [chemical binding]; other site 1160717004871 membrane-bound complex binding site; other site 1160717004872 hinge residues; other site 1160717004873 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1160717004874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004875 Walker A/P-loop; other site 1160717004876 ATP binding site [chemical binding]; other site 1160717004877 Q-loop/lid; other site 1160717004878 ABC transporter signature motif; other site 1160717004879 Walker B; other site 1160717004880 D-loop; other site 1160717004881 H-loop/switch region; other site 1160717004882 putative lipoprotein; Provisional; Region: PRK10533 1160717004883 hypothetical protein; Provisional; Region: PRK02877 1160717004884 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1160717004885 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1160717004886 amidase catalytic site [active] 1160717004887 Zn binding residues [ion binding]; other site 1160717004888 substrate binding site [chemical binding]; other site 1160717004889 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1160717004890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1160717004891 NAD(P) binding site [chemical binding]; other site 1160717004892 active site 1160717004893 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1160717004894 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1160717004895 putative NAD(P) binding site [chemical binding]; other site 1160717004896 putative active site [active] 1160717004897 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1160717004898 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1160717004899 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1160717004900 tetramer interface [polypeptide binding]; other site 1160717004901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717004902 catalytic residue [active] 1160717004903 pyruvate dehydrogenase; Provisional; Region: PRK09124 1160717004904 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1160717004905 PYR/PP interface [polypeptide binding]; other site 1160717004906 dimer interface [polypeptide binding]; other site 1160717004907 tetramer interface [polypeptide binding]; other site 1160717004908 TPP binding site [chemical binding]; other site 1160717004909 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1160717004910 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1160717004911 TPP-binding site [chemical binding]; other site 1160717004912 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1160717004913 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1160717004914 FAD binding pocket [chemical binding]; other site 1160717004915 FAD binding motif [chemical binding]; other site 1160717004916 phosphate binding motif [ion binding]; other site 1160717004917 beta-alpha-beta structure motif; other site 1160717004918 NAD binding pocket [chemical binding]; other site 1160717004919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1160717004920 catalytic loop [active] 1160717004921 iron binding site [ion binding]; other site 1160717004922 hybrid cluster protein; Provisional; Region: PRK05290 1160717004923 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717004924 ACS interaction site; other site 1160717004925 CODH interaction site; other site 1160717004926 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1160717004927 hybrid metal cluster; other site 1160717004928 Predicted membrane protein [Function unknown]; Region: COG2431 1160717004929 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1160717004930 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1160717004931 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1160717004932 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1160717004933 putative active site [active] 1160717004934 putative metal-binding site [ion binding]; other site 1160717004935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1160717004936 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1160717004937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717004938 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717004939 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1160717004940 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1160717004941 Walker A/P-loop; other site 1160717004942 ATP binding site [chemical binding]; other site 1160717004943 Q-loop/lid; other site 1160717004944 ABC transporter signature motif; other site 1160717004945 Walker B; other site 1160717004946 D-loop; other site 1160717004947 H-loop/switch region; other site 1160717004948 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1160717004949 FtsX-like permease family; Region: FtsX; pfam02687 1160717004950 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1160717004951 DNA-binding site [nucleotide binding]; DNA binding site 1160717004952 RNA-binding motif; other site 1160717004953 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1160717004954 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1160717004955 Clp amino terminal domain; Region: Clp_N; pfam02861 1160717004956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717004957 Walker A motif; other site 1160717004958 ATP binding site [chemical binding]; other site 1160717004959 Walker B motif; other site 1160717004960 arginine finger; other site 1160717004961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717004962 Walker A motif; other site 1160717004963 ATP binding site [chemical binding]; other site 1160717004964 Walker B motif; other site 1160717004965 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1160717004966 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1160717004967 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1160717004968 DNA binding site [nucleotide binding] 1160717004969 active site 1160717004970 Int/Topo IB signature motif; other site 1160717004971 Isochorismatase family; Region: Isochorismatase; pfam00857 1160717004972 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1160717004973 catalytic triad [active] 1160717004974 dimer interface [polypeptide binding]; other site 1160717004975 conserved cis-peptide bond; other site 1160717004976 Pirin-related protein [General function prediction only]; Region: COG1741 1160717004977 Pirin; Region: Pirin; pfam02678 1160717004978 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1160717004979 LysR family transcriptional regulator; Provisional; Region: PRK14997 1160717004980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717004981 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1160717004982 putative effector binding pocket; other site 1160717004983 putative dimerization interface [polypeptide binding]; other site 1160717004984 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1160717004985 rRNA binding site [nucleotide binding]; other site 1160717004986 predicted 30S ribosome binding site; other site 1160717004987 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1160717004988 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1160717004989 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717004990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717004991 Walker A/P-loop; other site 1160717004992 ATP binding site [chemical binding]; other site 1160717004993 Q-loop/lid; other site 1160717004994 ABC transporter signature motif; other site 1160717004995 Walker B; other site 1160717004996 D-loop; other site 1160717004997 H-loop/switch region; other site 1160717004998 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1160717004999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717005000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717005001 Walker A/P-loop; other site 1160717005002 ATP binding site [chemical binding]; other site 1160717005003 Q-loop/lid; other site 1160717005004 ABC transporter signature motif; other site 1160717005005 Walker B; other site 1160717005006 D-loop; other site 1160717005007 H-loop/switch region; other site 1160717005008 thioredoxin reductase; Provisional; Region: PRK10262 1160717005009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717005010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717005011 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1160717005012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717005013 putative DNA binding site [nucleotide binding]; other site 1160717005014 putative Zn2+ binding site [ion binding]; other site 1160717005015 AsnC family; Region: AsnC_trans_reg; pfam01037 1160717005016 DNA translocase FtsK; Provisional; Region: PRK10263 1160717005017 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1160717005018 DNA translocase FtsK; Provisional; Region: PRK10263 1160717005019 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1160717005020 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1160717005021 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1160717005022 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1160717005023 recombination factor protein RarA; Reviewed; Region: PRK13342 1160717005024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717005025 Walker A motif; other site 1160717005026 ATP binding site [chemical binding]; other site 1160717005027 Walker B motif; other site 1160717005028 arginine finger; other site 1160717005029 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1160717005030 seryl-tRNA synthetase; Provisional; Region: PRK05431 1160717005031 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1160717005032 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1160717005033 dimer interface [polypeptide binding]; other site 1160717005034 active site 1160717005035 motif 1; other site 1160717005036 motif 2; other site 1160717005037 motif 3; other site 1160717005038 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1160717005039 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1160717005040 putative [Fe4-S4] binding site [ion binding]; other site 1160717005041 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717005042 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1160717005043 putative molybdopterin cofactor binding site; other site 1160717005044 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1160717005045 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717005046 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1160717005047 putative MFS family transporter protein; Provisional; Region: PRK03633 1160717005048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717005049 putative substrate translocation pore; other site 1160717005050 inner membrane transporter YjeM; Provisional; Region: PRK15238 1160717005051 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1160717005052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717005053 FeS/SAM binding site; other site 1160717005054 integrase; Provisional; Region: int; PHA02601 1160717005055 Salmonella outer protein D; Region: SopD; cl14701 1160717005056 Salmonella outer protein D; Region: SopD; cl14701 1160717005057 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1160717005058 Pyruvate formate lyase 1; Region: PFL1; cd01678 1160717005059 coenzyme A binding site [chemical binding]; other site 1160717005060 active site 1160717005061 catalytic residues [active] 1160717005062 glycine loop; other site 1160717005063 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1160717005064 uncharacterized domain; Region: TIGR00702 1160717005065 YcaO-like family; Region: YcaO; pfam02624 1160717005066 Predicted membrane protein [Function unknown]; Region: COG2323 1160717005067 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1160717005068 homodimer interface [polypeptide binding]; other site 1160717005069 substrate-cofactor binding pocket; other site 1160717005070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717005071 catalytic residue [active] 1160717005072 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1160717005073 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1160717005074 hinge; other site 1160717005075 active site 1160717005076 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1160717005077 cytidylate kinase; Provisional; Region: cmk; PRK00023 1160717005078 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1160717005079 CMP-binding site; other site 1160717005080 The sites determining sugar specificity; other site 1160717005081 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1160717005082 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1160717005083 RNA binding site [nucleotide binding]; other site 1160717005084 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1160717005085 RNA binding site [nucleotide binding]; other site 1160717005086 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1160717005087 RNA binding site [nucleotide binding]; other site 1160717005088 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1160717005089 RNA binding site [nucleotide binding]; other site 1160717005090 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1160717005091 RNA binding site [nucleotide binding]; other site 1160717005092 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1160717005093 IHF dimer interface [polypeptide binding]; other site 1160717005094 IHF - DNA interface [nucleotide binding]; other site 1160717005095 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1160717005096 Competence protein; Region: Competence; pfam03772 1160717005097 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1160717005098 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1160717005099 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717005100 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1160717005101 Walker A/P-loop; other site 1160717005102 ATP binding site [chemical binding]; other site 1160717005103 Q-loop/lid; other site 1160717005104 ABC transporter signature motif; other site 1160717005105 Walker B; other site 1160717005106 D-loop; other site 1160717005107 H-loop/switch region; other site 1160717005108 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1160717005109 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1160717005110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1160717005111 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1160717005112 hypothetical protein; Provisional; Region: PRK11827 1160717005113 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1160717005114 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1160717005115 Ligand binding site; other site 1160717005116 oligomer interface; other site 1160717005117 hypothetical protein; Provisional; Region: PRK10593 1160717005118 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1160717005119 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1160717005120 putative active site [active] 1160717005121 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1160717005122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717005123 S-adenosylmethionine binding site [chemical binding]; other site 1160717005124 condesin subunit F; Provisional; Region: PRK05260 1160717005125 condesin subunit E; Provisional; Region: PRK05256 1160717005126 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1160717005127 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1160717005128 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1160717005129 murein L,D-transpeptidase; Provisional; Region: PRK10594 1160717005130 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1160717005131 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717005132 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717005133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1160717005134 Peptidase M15; Region: Peptidase_M15_3; cl01194 1160717005135 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1160717005136 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1160717005137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717005138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717005139 homodimer interface [polypeptide binding]; other site 1160717005140 catalytic residue [active] 1160717005141 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717005142 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717005143 trimer interface [polypeptide binding]; other site 1160717005144 eyelet of channel; other site 1160717005145 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1160717005146 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1160717005147 putative dimer interface [polypeptide binding]; other site 1160717005148 putative anticodon binding site; other site 1160717005149 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1160717005150 homodimer interface [polypeptide binding]; other site 1160717005151 motif 1; other site 1160717005152 motif 2; other site 1160717005153 active site 1160717005154 motif 3; other site 1160717005155 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1160717005156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717005157 putative DNA binding site [nucleotide binding]; other site 1160717005158 putative Zn2+ binding site [ion binding]; other site 1160717005159 AsnC family; Region: AsnC_trans_reg; pfam01037 1160717005160 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1160717005161 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1160717005162 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717005163 catalytic residue [active] 1160717005164 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1160717005165 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1160717005166 putative phage 1160717005167 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1160717005168 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1160717005169 active site 1160717005170 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1160717005171 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1160717005172 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1160717005173 Int/Topo IB signature motif; other site 1160717005174 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1160717005175 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1160717005176 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1160717005177 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1160717005178 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1160717005179 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1160717005180 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1160717005181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717005182 transcriptional repressor DicA; Reviewed; Region: PRK09706 1160717005183 non-specific DNA binding site [nucleotide binding]; other site 1160717005184 salt bridge; other site 1160717005185 sequence-specific DNA binding site [nucleotide binding]; other site 1160717005186 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1160717005187 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1160717005188 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1160717005189 Replication protein P; Region: Phage_lambda_P; pfam06992 1160717005190 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1160717005191 DinI-like family; Region: DinI; pfam06183 1160717005192 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1160717005193 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1160717005194 Antitermination protein; Region: Antiterm; pfam03589 1160717005195 Antitermination protein; Region: Antiterm; pfam03589 1160717005196 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1160717005197 catalytic residues [active] 1160717005198 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1160717005199 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1160717005200 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1160717005201 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 1160717005202 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1160717005203 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1160717005204 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1160717005205 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1160717005206 oligomer interface [polypeptide binding]; other site 1160717005207 active site residues [active] 1160717005208 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1160717005209 Uncharacterized conserved protein [Function unknown]; Region: COG5471 1160717005210 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1160717005211 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1160717005212 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1160717005213 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1160717005214 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1160717005215 Minor tail protein T; Region: Phage_tail_T; cl05636 1160717005216 Phage-related minor tail protein [Function unknown]; Region: COG5281 1160717005217 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1160717005218 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1160717005219 Phage-related protein [Function unknown]; Region: COG4718 1160717005220 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1160717005221 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1160717005222 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1160717005223 E-class dimer interface [polypeptide binding]; other site 1160717005224 P-class dimer interface [polypeptide binding]; other site 1160717005225 active site 1160717005226 Cu2+ binding site [ion binding]; other site 1160717005227 Zn2+ binding site [ion binding]; other site 1160717005228 Phage-related protein [Function unknown]; Region: gp18; COG4672 1160717005229 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1160717005230 MPN+ (JAMM) motif; other site 1160717005231 Zinc-binding site [ion binding]; other site 1160717005232 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1160717005233 NlpC/P60 family; Region: NLPC_P60; cl17555 1160717005234 Phage-related protein, tail component [Function unknown]; Region: COG4723 1160717005235 Phage-related protein, tail component [Function unknown]; Region: COG4733 1160717005236 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1160717005237 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1160717005238 Interdomain contacts; other site 1160717005239 Cytokine receptor motif; other site 1160717005240 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1160717005241 Fibronectin type III protein; Region: DUF3672; pfam12421 1160717005242 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1160717005243 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1160717005244 Phage Tail Collar Domain; Region: Collar; pfam07484 1160717005245 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1160717005246 ADP-ribose binding site [chemical binding]; other site 1160717005247 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1160717005248 SopE GEF domain; Region: SopE_GEF; pfam07487 1160717005249 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1160717005250 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1160717005251 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1160717005252 DNA-binding interface [nucleotide binding]; DNA binding site 1160717005253 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1160717005254 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1160717005255 aminopeptidase N; Provisional; Region: pepN; PRK14015 1160717005256 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1160717005257 active site 1160717005258 Zn binding site [ion binding]; other site 1160717005259 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1160717005260 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1160717005261 quinone interaction residues [chemical binding]; other site 1160717005262 active site 1160717005263 catalytic residues [active] 1160717005264 FMN binding site [chemical binding]; other site 1160717005265 substrate binding site [chemical binding]; other site 1160717005266 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1160717005267 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1160717005268 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1160717005269 MOSC domain; Region: MOSC; pfam03473 1160717005270 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1160717005271 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1160717005272 catalytic loop [active] 1160717005273 iron binding site [ion binding]; other site 1160717005274 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1160717005275 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1160717005276 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1160717005277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717005278 S-adenosylmethionine binding site [chemical binding]; other site 1160717005279 ABC transporter ATPase component; Reviewed; Region: PRK11147 1160717005280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717005281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717005282 Walker A/P-loop; other site 1160717005283 Walker A/P-loop; other site 1160717005284 ATP binding site [chemical binding]; other site 1160717005285 ATP binding site [chemical binding]; other site 1160717005286 Q-loop/lid; other site 1160717005287 Q-loop/lid; other site 1160717005288 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717005289 ABC transporter signature motif; other site 1160717005290 Walker B; other site 1160717005291 D-loop; other site 1160717005292 ABC transporter; Region: ABC_tran_2; pfam12848 1160717005293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717005294 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1160717005295 Paraquat-inducible protein A; Region: PqiA; pfam04403 1160717005296 Paraquat-inducible protein A; Region: PqiA; pfam04403 1160717005297 paraquat-inducible protein B; Provisional; Region: PRK10807 1160717005298 mce related protein; Region: MCE; pfam02470 1160717005299 mce related protein; Region: MCE; pfam02470 1160717005300 mce related protein; Region: MCE; pfam02470 1160717005301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1160717005302 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1160717005303 Ribosome modulation factor; Region: RMF; cl01207 1160717005304 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1160717005305 active site 1 [active] 1160717005306 dimer interface [polypeptide binding]; other site 1160717005307 active site 2 [active] 1160717005308 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1160717005309 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1160717005310 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1160717005311 outer membrane protein A; Reviewed; Region: PRK10808 1160717005312 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1160717005313 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1160717005314 ligand binding site [chemical binding]; other site 1160717005315 cell division inhibitor SulA; Region: sula; TIGR00623 1160717005316 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1160717005317 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1160717005318 TIGR01666 family membrane protein; Region: YCCS 1160717005319 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1160717005320 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1160717005321 Predicted membrane protein [Function unknown]; Region: COG3304 1160717005322 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1160717005323 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1160717005324 DNA helicase IV; Provisional; Region: helD; PRK11054 1160717005325 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1160717005326 Part of AAA domain; Region: AAA_19; pfam13245 1160717005327 Family description; Region: UvrD_C_2; pfam13538 1160717005328 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1160717005329 active site 1160717005330 dimer interfaces [polypeptide binding]; other site 1160717005331 catalytic residues [active] 1160717005332 hypothetical protein; Provisional; Region: PRK03641 1160717005333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1160717005334 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1160717005335 heat shock protein HspQ; Provisional; Region: PRK14129 1160717005336 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1160717005337 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1160717005338 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1160717005339 putative RNA binding site [nucleotide binding]; other site 1160717005340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717005341 S-adenosylmethionine binding site [chemical binding]; other site 1160717005342 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1160717005343 substrate binding site [chemical binding]; other site 1160717005344 Cupin domain; Region: Cupin_2; cl17218 1160717005345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717005346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717005347 acylphosphatase; Provisional; Region: PRK14426 1160717005348 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1160717005349 sulfur transfer protein TusE; Provisional; Region: PRK11508 1160717005350 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1160717005351 YccA-like proteins; Region: YccA_like; cd10433 1160717005352 PipA protein; Region: PipA; pfam07108 1160717005353 secreted effector protein PipB; Provisional; Region: PRK15197 1160717005354 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717005355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717005356 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717005357 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 1160717005358 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 1160717005359 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 1160717005360 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1160717005361 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1160717005362 HAMP domain; Region: HAMP; pfam00672 1160717005363 dimerization interface [polypeptide binding]; other site 1160717005364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717005365 dimer interface [polypeptide binding]; other site 1160717005366 phosphorylation site [posttranslational modification] 1160717005367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717005368 ATP binding site [chemical binding]; other site 1160717005369 Mg2+ binding site [ion binding]; other site 1160717005370 G-X-G motif; other site 1160717005371 Response regulator receiver domain; Region: Response_reg; pfam00072 1160717005372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717005373 active site 1160717005374 phosphorylation site [posttranslational modification] 1160717005375 intermolecular recognition site; other site 1160717005376 dimerization interface [polypeptide binding]; other site 1160717005377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717005378 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1160717005379 active site 1160717005380 homotetramer interface [polypeptide binding]; other site 1160717005381 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1160717005382 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1160717005383 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1160717005384 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1160717005385 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1160717005386 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1160717005387 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1160717005388 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1160717005389 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1160717005390 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1160717005391 NAD binding site [chemical binding]; other site 1160717005392 catalytic residues [active] 1160717005393 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1160717005394 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1160717005395 putative active site [active] 1160717005396 putative metal binding site [ion binding]; other site 1160717005397 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1160717005398 putative substrate binding pocket [chemical binding]; other site 1160717005399 trimer interface [polypeptide binding]; other site 1160717005400 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1160717005401 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1160717005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717005403 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1160717005404 putative substrate translocation pore; other site 1160717005405 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1160717005406 Cupin domain; Region: Cupin_2; pfam07883 1160717005407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717005408 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1160717005409 anti-adapter protein IraM; Provisional; Region: PRK09919 1160717005410 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1160717005411 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1160717005412 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1160717005413 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1160717005414 HSP70 interaction site [polypeptide binding]; other site 1160717005415 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1160717005416 substrate binding site [polypeptide binding]; other site 1160717005417 dimer interface [polypeptide binding]; other site 1160717005418 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1160717005419 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1160717005420 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1160717005421 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1160717005422 DsbD alpha interface [polypeptide binding]; other site 1160717005423 catalytic residues [active] 1160717005424 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1160717005425 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1160717005426 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1160717005427 catalytic residues [active] 1160717005428 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1160717005429 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1160717005430 catalytic residues [active] 1160717005431 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1160717005432 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1160717005433 catalytic core [active] 1160717005434 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1160717005435 hypothetical protein; Provisional; Region: PRK10174 1160717005436 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1160717005437 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1160717005438 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1160717005439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717005440 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1160717005441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1160717005442 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1160717005443 Predicted transcriptional regulator [Transcription]; Region: COG3905 1160717005444 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1160717005445 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1160717005446 Glutamate binding site [chemical binding]; other site 1160717005447 NAD binding site [chemical binding]; other site 1160717005448 catalytic residues [active] 1160717005449 genomic island 1160717005450 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1160717005451 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1160717005452 Na binding site [ion binding]; other site 1160717005453 hypothetical protein; Provisional; Region: PRK10536 1160717005454 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1160717005455 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1160717005456 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1160717005457 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1160717005458 putative active site [active] 1160717005459 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1160717005460 Na binding site [ion binding]; other site 1160717005461 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1160717005462 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1160717005463 putative active site cavity [active] 1160717005464 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1160717005465 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1160717005466 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1160717005467 putative sialic acid transporter; Provisional; Region: PRK12307 1160717005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717005469 putative substrate translocation pore; other site 1160717005470 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1160717005471 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1160717005472 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1160717005473 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1160717005474 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1160717005475 putative ligand binding site [chemical binding]; other site 1160717005476 NAD binding site [chemical binding]; other site 1160717005477 dimerization interface [polypeptide binding]; other site 1160717005478 catalytic site [active] 1160717005479 putative hydrolase; Validated; Region: PRK09248 1160717005480 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1160717005481 active site 1160717005482 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1160717005483 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1160717005484 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1160717005485 curli assembly protein CsgF; Provisional; Region: PRK10050 1160717005486 curli assembly protein CsgE; Provisional; Region: PRK10386 1160717005487 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1160717005488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717005489 DNA binding residues [nucleotide binding] 1160717005490 dimerization interface [polypeptide binding]; other site 1160717005491 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1160717005492 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1160717005493 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1160717005494 major curlin subunit; Provisional; Region: csgA; PRK10051 1160717005495 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1160717005496 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1160717005497 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1160717005498 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1160717005499 putative ADP-ribose binding site [chemical binding]; other site 1160717005500 putative active site [active] 1160717005501 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1160717005502 PLD-like domain; Region: PLDc_2; pfam13091 1160717005503 putative active site [active] 1160717005504 catalytic site [active] 1160717005505 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1160717005506 PLD-like domain; Region: PLDc_2; pfam13091 1160717005507 putative active site [active] 1160717005508 catalytic site [active] 1160717005509 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1160717005510 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1160717005511 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1160717005512 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1160717005513 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1160717005514 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1160717005515 Ligand binding site; other site 1160717005516 DXD motif; other site 1160717005517 lipoprotein; Provisional; Region: PRK10175 1160717005518 secY/secA suppressor protein; Provisional; Region: PRK11467 1160717005519 drug efflux system protein MdtG; Provisional; Region: PRK09874 1160717005520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717005521 putative substrate translocation pore; other site 1160717005522 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1160717005523 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1160717005524 putative acyl-acceptor binding pocket; other site 1160717005525 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1160717005526 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1160717005527 active site residue [active] 1160717005528 hypothetical protein; Provisional; Region: PRK03757 1160717005529 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1160717005530 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1160717005531 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1160717005532 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1160717005533 DNA damage-inducible protein I; Provisional; Region: PRK10597 1160717005534 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1160717005535 active site 1160717005536 substrate binding pocket [chemical binding]; other site 1160717005537 dimer interface [polypeptide binding]; other site 1160717005538 lipoprotein; Provisional; Region: PRK10598 1160717005539 glutaredoxin 2; Provisional; Region: PRK10387 1160717005540 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1160717005541 C-terminal domain interface [polypeptide binding]; other site 1160717005542 GSH binding site (G-site) [chemical binding]; other site 1160717005543 catalytic residues [active] 1160717005544 putative dimer interface [polypeptide binding]; other site 1160717005545 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1160717005546 N-terminal domain interface [polypeptide binding]; other site 1160717005547 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1160717005548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717005549 putative substrate translocation pore; other site 1160717005550 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1160717005551 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1160717005552 hypothetical protein; Provisional; Region: PRK11239 1160717005553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1160717005554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1160717005555 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1160717005556 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1160717005557 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1160717005558 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1160717005559 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1160717005560 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1160717005561 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1160717005562 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1160717005563 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1160717005564 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1160717005565 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1160717005566 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1160717005567 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1160717005568 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1160717005569 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1160717005570 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1160717005571 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1160717005572 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1160717005573 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1160717005574 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1160717005575 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1160717005576 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1160717005577 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1160717005578 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1160717005579 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1160717005580 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1160717005581 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1160717005582 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1160717005583 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1160717005584 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1160717005585 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1160717005586 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1160717005587 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1160717005588 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1160717005589 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1160717005590 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1160717005591 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1160717005592 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1160717005593 ribonuclease E; Reviewed; Region: rne; PRK10811 1160717005594 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1160717005595 homodimer interface [polypeptide binding]; other site 1160717005596 oligonucleotide binding site [chemical binding]; other site 1160717005597 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1160717005598 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1160717005599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717005600 RNA binding surface [nucleotide binding]; other site 1160717005601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1160717005602 active site 1160717005603 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1160717005604 Maf-like protein; Region: Maf; pfam02545 1160717005605 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1160717005606 active site 1160717005607 dimer interface [polypeptide binding]; other site 1160717005608 hypothetical protein; Provisional; Region: PRK11193 1160717005609 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1160717005610 putative phosphate acyltransferase; Provisional; Region: PRK05331 1160717005611 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1160717005612 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1160717005613 dimer interface [polypeptide binding]; other site 1160717005614 active site 1160717005615 CoA binding pocket [chemical binding]; other site 1160717005616 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1160717005617 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1160717005618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1160717005619 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1160717005620 NAD(P) binding site [chemical binding]; other site 1160717005621 homotetramer interface [polypeptide binding]; other site 1160717005622 homodimer interface [polypeptide binding]; other site 1160717005623 active site 1160717005624 acyl carrier protein; Provisional; Region: acpP; PRK00982 1160717005625 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1160717005626 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1160717005627 dimer interface [polypeptide binding]; other site 1160717005628 active site 1160717005629 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1160717005630 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1160717005631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717005632 catalytic residue [active] 1160717005633 conserved hypothetical protein, YceG family; Region: TIGR00247 1160717005634 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1160717005635 dimerization interface [polypeptide binding]; other site 1160717005636 thymidylate kinase; Validated; Region: tmk; PRK00698 1160717005637 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1160717005638 TMP-binding site; other site 1160717005639 ATP-binding site [chemical binding]; other site 1160717005640 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1160717005641 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1160717005642 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1160717005643 active site 1160717005644 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1160717005645 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1160717005646 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1160717005647 active site turn [active] 1160717005648 phosphorylation site [posttranslational modification] 1160717005649 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1160717005650 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1160717005651 N-terminal plug; other site 1160717005652 ligand-binding site [chemical binding]; other site 1160717005653 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1160717005654 nucleotide binding site/active site [active] 1160717005655 HIT family signature motif; other site 1160717005656 catalytic residue [active] 1160717005657 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1160717005658 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1160717005659 putative dimer interface [polypeptide binding]; other site 1160717005660 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1160717005661 thiamine kinase; Region: ycfN_thiK; TIGR02721 1160717005662 thiamine kinase; Provisional; Region: thiK; PRK10271 1160717005663 substrate binding site [chemical binding]; other site 1160717005664 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1160717005665 beta-hexosaminidase; Provisional; Region: PRK05337 1160717005666 hypothetical protein; Provisional; Region: PRK04940 1160717005667 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1160717005668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717005669 hypothetical protein; Provisional; Region: PRK11280 1160717005670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1160717005671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717005672 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717005673 L,D-transpeptidase; Provisional; Region: PRK10190 1160717005674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717005675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717005676 transcription-repair coupling factor; Provisional; Region: PRK10689 1160717005677 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1160717005678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717005679 ATP binding site [chemical binding]; other site 1160717005680 putative Mg++ binding site [ion binding]; other site 1160717005681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717005682 nucleotide binding region [chemical binding]; other site 1160717005683 ATP-binding site [chemical binding]; other site 1160717005684 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1160717005685 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1160717005686 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1160717005687 FtsX-like permease family; Region: FtsX; pfam02687 1160717005688 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1160717005689 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1160717005690 Walker A/P-loop; other site 1160717005691 ATP binding site [chemical binding]; other site 1160717005692 Q-loop/lid; other site 1160717005693 ABC transporter signature motif; other site 1160717005694 Walker B; other site 1160717005695 D-loop; other site 1160717005696 H-loop/switch region; other site 1160717005697 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1160717005698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1160717005699 FtsX-like permease family; Region: FtsX; pfam02687 1160717005700 fructokinase; Reviewed; Region: PRK09557 1160717005701 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717005702 nucleotide binding site [chemical binding]; other site 1160717005703 NAD-dependent deacetylase; Provisional; Region: PRK00481 1160717005704 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1160717005705 NAD+ binding site [chemical binding]; other site 1160717005706 substrate binding site [chemical binding]; other site 1160717005707 Zn binding site [ion binding]; other site 1160717005708 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1160717005709 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1160717005710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1160717005711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717005712 dimer interface [polypeptide binding]; other site 1160717005713 conserved gate region; other site 1160717005714 putative PBP binding loops; other site 1160717005715 ABC-ATPase subunit interface; other site 1160717005716 Sif protein; Region: Sif; cl11505 1160717005717 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1160717005718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717005719 dimer interface [polypeptide binding]; other site 1160717005720 conserved gate region; other site 1160717005721 putative PBP binding loops; other site 1160717005722 ABC-ATPase subunit interface; other site 1160717005723 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1160717005724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717005725 Walker A/P-loop; other site 1160717005726 ATP binding site [chemical binding]; other site 1160717005727 Q-loop/lid; other site 1160717005728 ABC transporter signature motif; other site 1160717005729 Walker B; other site 1160717005730 D-loop; other site 1160717005731 H-loop/switch region; other site 1160717005732 TOBE domain; Region: TOBE_2; pfam08402 1160717005733 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1160717005734 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1160717005735 metal binding site [ion binding]; metal-binding site 1160717005736 dimer interface [polypeptide binding]; other site 1160717005737 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1160717005738 Cupin-like domain; Region: Cupin_8; pfam13621 1160717005739 sensor protein PhoQ; Provisional; Region: PRK10815 1160717005740 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1160717005741 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1160717005742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717005743 ATP binding site [chemical binding]; other site 1160717005744 Mg2+ binding site [ion binding]; other site 1160717005745 G-X-G motif; other site 1160717005746 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1160717005747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717005748 active site 1160717005749 phosphorylation site [posttranslational modification] 1160717005750 intermolecular recognition site; other site 1160717005751 dimerization interface [polypeptide binding]; other site 1160717005752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717005753 DNA binding site [nucleotide binding] 1160717005754 adenylosuccinate lyase; Provisional; Region: PRK09285 1160717005755 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1160717005756 tetramer interface [polypeptide binding]; other site 1160717005757 active site 1160717005758 putative lysogenization regulator; Reviewed; Region: PRK00218 1160717005759 genomic island 1160717005760 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1160717005761 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1160717005762 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1160717005763 nudix motif; other site 1160717005764 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1160717005765 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1160717005766 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1160717005767 pseudouridine synthase; Region: TIGR00093 1160717005768 probable active site [active] 1160717005769 isocitrate dehydrogenase; Validated; Region: PRK07362 1160717005770 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1160717005771 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1160717005772 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1160717005773 DinI-like family; Region: DinI; pfam06183 1160717005774 Ricin-type beta-trefoil; Region: RICIN; smart00458 1160717005775 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1160717005776 putative sugar binding sites [chemical binding]; other site 1160717005777 Q-X-W motif; other site 1160717005778 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1160717005779 lysozyme inhibitor; Provisional; Region: PRK13791 1160717005780 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1160717005781 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1160717005782 putative dimer interface [polypeptide binding]; other site 1160717005783 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1160717005784 BNR repeat-like domain; Region: BNR_2; pfam13088 1160717005785 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1160717005786 TRL-like protein family; Region: TRL; pfam13146 1160717005787 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1160717005788 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1160717005789 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1160717005790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717005791 dimer interface [polypeptide binding]; other site 1160717005792 conserved gate region; other site 1160717005793 ABC-ATPase subunit interface; other site 1160717005794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1160717005795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717005796 dimer interface [polypeptide binding]; other site 1160717005797 conserved gate region; other site 1160717005798 putative PBP binding loops; other site 1160717005799 ABC-ATPase subunit interface; other site 1160717005800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717005801 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1160717005802 Walker A/P-loop; other site 1160717005803 ATP binding site [chemical binding]; other site 1160717005804 Q-loop/lid; other site 1160717005805 ABC transporter signature motif; other site 1160717005806 Walker B; other site 1160717005807 D-loop; other site 1160717005808 H-loop/switch region; other site 1160717005809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717005810 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1160717005811 Walker A/P-loop; other site 1160717005812 ATP binding site [chemical binding]; other site 1160717005813 Q-loop/lid; other site 1160717005814 ABC transporter signature motif; other site 1160717005815 Walker B; other site 1160717005816 D-loop; other site 1160717005817 H-loop/switch region; other site 1160717005818 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1160717005819 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717005820 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1160717005821 dimerization interface [polypeptide binding]; other site 1160717005822 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1160717005823 aminoglycoside resistance protein; Provisional; Region: PRK13746 1160717005824 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1160717005825 active site 1160717005826 NTP binding site [chemical binding]; other site 1160717005827 metal binding triad [ion binding]; metal-binding site 1160717005828 antibiotic binding site [chemical binding]; other site 1160717005829 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1160717005830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717005831 DNA binding residues [nucleotide binding] 1160717005832 Pleckstrin homology-like domain; Region: PH-like; cl17171 1160717005833 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1160717005834 chorismate mutase; Provisional; Region: PRK08055 1160717005835 leucine export protein LeuE; Provisional; Region: PRK10958 1160717005836 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1160717005837 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1160717005838 Phage Tail Collar Domain; Region: Collar; pfam07484 1160717005839 hypothetical protein; Provisional; Region: PRK10457 1160717005840 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1160717005841 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1160717005842 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1160717005843 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1160717005844 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1160717005845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717005846 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717005847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717005848 Predicted membrane protein [Function unknown]; Region: COG2707 1160717005849 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1160717005850 putative deacylase active site [active] 1160717005851 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1160717005852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717005853 metal binding site [ion binding]; metal-binding site 1160717005854 active site 1160717005855 I-site; other site 1160717005856 hypothetical protein; Provisional; Region: PRK05325 1160717005857 PrkA family serine protein kinase; Provisional; Region: PRK15455 1160717005858 AAA ATPase domain; Region: AAA_16; pfam13191 1160717005859 Walker A motif; other site 1160717005860 ATP binding site [chemical binding]; other site 1160717005861 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1160717005862 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1160717005863 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1160717005864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717005865 FeS/SAM binding site; other site 1160717005866 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1160717005867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717005868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717005869 active site 1160717005870 catalytic tetrad [active] 1160717005871 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1160717005872 active site 1160717005873 phosphate binding residues; other site 1160717005874 catalytic residues [active] 1160717005875 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1160717005876 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1160717005877 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1160717005878 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1160717005879 SelR domain; Region: SelR; pfam01641 1160717005880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1160717005881 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1160717005882 Isochorismatase family; Region: Isochorismatase; pfam00857 1160717005883 catalytic triad [active] 1160717005884 metal binding site [ion binding]; metal-binding site 1160717005885 conserved cis-peptide bond; other site 1160717005886 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1160717005887 active site 1160717005888 homodimer interface [polypeptide binding]; other site 1160717005889 protease 4; Provisional; Region: PRK10949 1160717005890 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1160717005891 tandem repeat interface [polypeptide binding]; other site 1160717005892 oligomer interface [polypeptide binding]; other site 1160717005893 active site residues [active] 1160717005894 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1160717005895 tandem repeat interface [polypeptide binding]; other site 1160717005896 oligomer interface [polypeptide binding]; other site 1160717005897 active site residues [active] 1160717005898 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1160717005899 putative FMN binding site [chemical binding]; other site 1160717005900 selenophosphate synthetase; Provisional; Region: PRK00943 1160717005901 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1160717005902 dimerization interface [polypeptide binding]; other site 1160717005903 putative ATP binding site [chemical binding]; other site 1160717005904 DNA topoisomerase III; Provisional; Region: PRK07726 1160717005905 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1160717005906 active site 1160717005907 putative interdomain interaction site [polypeptide binding]; other site 1160717005908 putative metal-binding site [ion binding]; other site 1160717005909 putative nucleotide binding site [chemical binding]; other site 1160717005910 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1160717005911 domain I; other site 1160717005912 DNA binding groove [nucleotide binding] 1160717005913 phosphate binding site [ion binding]; other site 1160717005914 domain II; other site 1160717005915 domain III; other site 1160717005916 nucleotide binding site [chemical binding]; other site 1160717005917 catalytic site [active] 1160717005918 domain IV; other site 1160717005919 glutamate dehydrogenase; Provisional; Region: PRK09414 1160717005920 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1160717005921 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1160717005922 NAD(P) binding site [chemical binding]; other site 1160717005923 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1160717005924 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1160717005925 active site 1160717005926 8-oxo-dGMP binding site [chemical binding]; other site 1160717005927 nudix motif; other site 1160717005928 metal binding site [ion binding]; metal-binding site 1160717005929 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1160717005930 putative catalytic site [active] 1160717005931 putative phosphate binding site [ion binding]; other site 1160717005932 active site 1160717005933 metal binding site A [ion binding]; metal-binding site 1160717005934 DNA binding site [nucleotide binding] 1160717005935 putative AP binding site [nucleotide binding]; other site 1160717005936 putative metal binding site B [ion binding]; other site 1160717005937 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1160717005938 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1160717005939 inhibitor-cofactor binding pocket; inhibition site 1160717005940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717005941 catalytic residue [active] 1160717005942 arginine succinyltransferase; Provisional; Region: PRK10456 1160717005943 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1160717005944 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1160717005945 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1160717005946 NAD(P) binding site [chemical binding]; other site 1160717005947 catalytic residues [active] 1160717005948 succinylarginine dihydrolase; Provisional; Region: PRK13281 1160717005949 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1160717005950 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1160717005951 putative active site [active] 1160717005952 Zn binding site [ion binding]; other site 1160717005953 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1160717005954 dimer interface [polypeptide binding]; other site 1160717005955 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1160717005956 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1160717005957 GIY-YIG motif/motif A; other site 1160717005958 active site 1160717005959 catalytic site [active] 1160717005960 putative DNA binding site [nucleotide binding]; other site 1160717005961 metal binding site [ion binding]; metal-binding site 1160717005962 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1160717005963 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1160717005964 active site 1160717005965 P-loop; other site 1160717005966 phosphorylation site [posttranslational modification] 1160717005967 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1160717005968 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1160717005969 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1160717005970 methionine cluster; other site 1160717005971 active site 1160717005972 phosphorylation site [posttranslational modification] 1160717005973 metal binding site [ion binding]; metal-binding site 1160717005974 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1160717005975 Cupin domain; Region: Cupin_2; pfam07883 1160717005976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717005977 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1160717005978 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1160717005979 NAD binding site [chemical binding]; other site 1160717005980 sugar binding site [chemical binding]; other site 1160717005981 divalent metal binding site [ion binding]; other site 1160717005982 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1160717005983 dimer interface [polypeptide binding]; other site 1160717005984 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1160717005985 putative active site [active] 1160717005986 YdjC motif; other site 1160717005987 Mg binding site [ion binding]; other site 1160717005988 putative homodimer interface [polypeptide binding]; other site 1160717005989 hydroperoxidase II; Provisional; Region: katE; PRK11249 1160717005990 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1160717005991 tetramer interface [polypeptide binding]; other site 1160717005992 heme binding pocket [chemical binding]; other site 1160717005993 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1160717005994 domain interactions; other site 1160717005995 cell division modulator; Provisional; Region: PRK10113 1160717005996 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1160717005997 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1160717005998 inner membrane protein; Provisional; Region: PRK11648 1160717005999 genomic island 1160717006000 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1160717006001 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1160717006002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717006003 motif II; other site 1160717006004 YniB-like protein; Region: YniB; pfam14002 1160717006005 Phosphotransferase enzyme family; Region: APH; pfam01636 1160717006006 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1160717006007 active site 1160717006008 ATP binding site [chemical binding]; other site 1160717006009 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1160717006010 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1160717006011 6-phosphofructokinase 2; Provisional; Region: PRK10294 1160717006012 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1160717006013 putative substrate binding site [chemical binding]; other site 1160717006014 putative ATP binding site [chemical binding]; other site 1160717006015 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1160717006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1160717006017 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1160717006018 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1160717006019 active site 1160717006020 substrate binding site [chemical binding]; other site 1160717006021 Mg2+ binding site [ion binding]; other site 1160717006022 potential frameshift: common BLAST hit: gi|378988673|ref|YP_005251837.1| O-antigen polymerase 1160717006023 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1160717006024 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1160717006025 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1160717006026 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1160717006027 active site 1160717006028 dimer interface [polypeptide binding]; other site 1160717006029 motif 1; other site 1160717006030 motif 2; other site 1160717006031 motif 3; other site 1160717006032 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1160717006033 anticodon binding site; other site 1160717006034 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1160717006035 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1160717006036 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1160717006037 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1160717006038 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1160717006039 23S rRNA binding site [nucleotide binding]; other site 1160717006040 L21 binding site [polypeptide binding]; other site 1160717006041 L13 binding site [polypeptide binding]; other site 1160717006042 Phe_leader; SU5_nc69 1160717006043 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1160717006044 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1160717006045 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1160717006046 dimer interface [polypeptide binding]; other site 1160717006047 motif 1; other site 1160717006048 active site 1160717006049 motif 2; other site 1160717006050 motif 3; other site 1160717006051 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1160717006052 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1160717006053 putative tRNA-binding site [nucleotide binding]; other site 1160717006054 B3/4 domain; Region: B3_4; pfam03483 1160717006055 tRNA synthetase B5 domain; Region: B5; smart00874 1160717006056 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1160717006057 dimer interface [polypeptide binding]; other site 1160717006058 motif 1; other site 1160717006059 motif 3; other site 1160717006060 motif 2; other site 1160717006061 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1160717006062 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1160717006063 IHF dimer interface [polypeptide binding]; other site 1160717006064 IHF - DNA interface [nucleotide binding]; other site 1160717006065 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1160717006066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717006067 ABC-ATPase subunit interface; other site 1160717006068 dimer interface [polypeptide binding]; other site 1160717006069 putative PBP binding regions; other site 1160717006070 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1160717006071 catalytic residues [active] 1160717006072 dimer interface [polypeptide binding]; other site 1160717006073 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 1160717006074 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1160717006075 Walker A/P-loop; other site 1160717006076 ATP binding site [chemical binding]; other site 1160717006077 Q-loop/lid; other site 1160717006078 ABC transporter signature motif; other site 1160717006079 Walker B; other site 1160717006080 D-loop; other site 1160717006081 H-loop/switch region; other site 1160717006082 NlpC/P60 family; Region: NLPC_P60; pfam00877 1160717006083 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1160717006084 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1160717006085 hypothetical protein; Validated; Region: PRK00029 1160717006086 hypothetical protein; Provisional; Region: PRK10183 1160717006087 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1160717006088 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1160717006089 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1160717006090 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1160717006091 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1160717006092 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1160717006093 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1160717006094 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1160717006095 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1160717006096 acyl-activating enzyme (AAE) consensus motif; other site 1160717006097 putative AMP binding site [chemical binding]; other site 1160717006098 putative active site [active] 1160717006099 putative CoA binding site [chemical binding]; other site 1160717006100 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1160717006101 oxidoreductase; Provisional; Region: PRK10015 1160717006102 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1160717006103 Electron transfer flavoprotein domain; Region: ETF; smart00893 1160717006104 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1160717006105 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1160717006106 Ligand binding site [chemical binding]; other site 1160717006107 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1160717006108 Cupin domain; Region: Cupin_2; pfam07883 1160717006109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717006110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717006111 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1160717006112 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1160717006113 active site 1160717006114 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1160717006115 Coenzyme A transferase; Region: CoA_trans; smart00882 1160717006116 Coenzyme A transferase; Region: CoA_trans; cl17247 1160717006117 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1160717006118 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1160717006119 active site 1160717006120 catalytic residue [active] 1160717006121 dimer interface [polypeptide binding]; other site 1160717006122 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1160717006123 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1160717006124 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1160717006125 shikimate binding site; other site 1160717006126 NAD(P) binding site [chemical binding]; other site 1160717006127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717006129 putative substrate translocation pore; other site 1160717006130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717006132 putative substrate translocation pore; other site 1160717006133 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1160717006134 putative inner membrane protein; Provisional; Region: PRK10983 1160717006135 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1160717006136 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1160717006137 FAD binding domain; Region: FAD_binding_4; pfam01565 1160717006138 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1160717006139 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1160717006140 CoenzymeA binding site [chemical binding]; other site 1160717006141 subunit interaction site [polypeptide binding]; other site 1160717006142 PHB binding site; other site 1160717006143 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1160717006144 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1160717006145 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1160717006146 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1160717006147 putative ABC transporter; Region: ycf24; CHL00085 1160717006148 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1160717006149 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1160717006150 Walker A/P-loop; other site 1160717006151 ATP binding site [chemical binding]; other site 1160717006152 Q-loop/lid; other site 1160717006153 ABC transporter signature motif; other site 1160717006154 Walker B; other site 1160717006155 D-loop; other site 1160717006156 H-loop/switch region; other site 1160717006157 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1160717006158 FeS assembly protein SufD; Region: sufD; TIGR01981 1160717006159 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1160717006160 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1160717006161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717006162 catalytic residue [active] 1160717006163 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1160717006164 L,D-transpeptidase; Provisional; Region: PRK10190 1160717006165 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717006166 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717006167 murein lipoprotein; Provisional; Region: PRK15396 1160717006168 murein lipoprotein; Provisional; Region: PRK15396 1160717006169 murein lipoprotein; Provisional; Region: PRK15396 1160717006170 pyruvate kinase; Provisional; Region: PRK09206 1160717006171 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1160717006172 domain interfaces; other site 1160717006173 active site 1160717006174 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1160717006175 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1160717006176 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1160717006177 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717006178 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717006179 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717006180 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1160717006181 substrate binding site [chemical binding]; other site 1160717006182 dimer interface [polypeptide binding]; other site 1160717006183 ATP binding site [chemical binding]; other site 1160717006184 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1160717006185 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1160717006186 putative [Fe4-S4] binding site [ion binding]; other site 1160717006187 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717006188 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1160717006189 putative molybdopterin cofactor binding site; other site 1160717006190 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1160717006191 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1160717006192 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1160717006193 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717006194 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1160717006195 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1160717006196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1160717006197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717006198 dimer interface [polypeptide binding]; other site 1160717006199 phosphorylation site [posttranslational modification] 1160717006200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717006201 ATP binding site [chemical binding]; other site 1160717006202 Mg2+ binding site [ion binding]; other site 1160717006203 G-X-G motif; other site 1160717006204 genomic island 1160717006205 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1160717006206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717006207 active site 1160717006208 phosphorylation site [posttranslational modification] 1160717006209 intermolecular recognition site; other site 1160717006210 dimerization interface [polypeptide binding]; other site 1160717006211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717006212 DNA binding residues [nucleotide binding] 1160717006213 dimerization interface [polypeptide binding]; other site 1160717006214 hypothetical protein; Provisional; Region: PRK10292 1160717006215 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1160717006216 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1160717006217 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1160717006218 transcriptional regulator MirA; Provisional; Region: PRK15043 1160717006219 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1160717006220 DNA binding residues [nucleotide binding] 1160717006221 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1160717006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717006223 active site 1160717006224 phosphorylation site [posttranslational modification] 1160717006225 intermolecular recognition site; other site 1160717006226 dimerization interface [polypeptide binding]; other site 1160717006227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717006228 DNA binding residues [nucleotide binding] 1160717006229 dimerization interface [polypeptide binding]; other site 1160717006230 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1160717006231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717006232 dimerization interface [polypeptide binding]; other site 1160717006233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717006234 dimer interface [polypeptide binding]; other site 1160717006235 phosphorylation site [posttranslational modification] 1160717006236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717006237 ATP binding site [chemical binding]; other site 1160717006238 Mg2+ binding site [ion binding]; other site 1160717006239 G-X-G motif; other site 1160717006240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717006241 active site 1160717006242 phosphorylation site [posttranslational modification] 1160717006243 intermolecular recognition site; other site 1160717006244 dimerization interface [polypeptide binding]; other site 1160717006245 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 1160717006246 outer membrane secretin SsaC; Provisional; Region: PRK15346 1160717006247 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1160717006248 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1160717006249 type III secretion system protein SsaD; Provisional; Region: PRK15367 1160717006250 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1160717006251 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 1160717006252 type III secretion system chaperone SseA; Provisional; Region: PRK15365 1160717006253 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 1160717006254 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 1160717006255 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 1160717006256 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 1160717006257 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 1160717006258 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 1160717006259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1160717006260 TPR motif; other site 1160717006261 binding surface 1160717006262 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 1160717006263 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 1160717006264 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 1160717006265 type III secretion system protein SsaH; Provisional; Region: PRK15356 1160717006266 type III secretion system protein SsaI; Provisional; Region: PRK15355 1160717006267 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 1160717006268 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 1160717006269 type III secretion system protein SsaK; Provisional; Region: PRK15354 1160717006270 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1160717006271 type III secretion system protein SsaL; Provisional; Region: PRK15345 1160717006272 HrpJ-like domain; Region: HrpJ; pfam07201 1160717006273 TyeA; Region: TyeA; cl07611 1160717006274 type III secretion system protein SsaM; Provisional; Region: PRK15353 1160717006275 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 1160717006276 FHIPEP family; Region: FHIPEP; pfam00771 1160717006277 type III secretion system ATPase SsaN; Validated; Region: PRK07594 1160717006278 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1160717006279 Walker A motif; other site 1160717006280 ATP binding site [chemical binding]; other site 1160717006281 Walker B motif; other site 1160717006282 type III secretion system protein SsaO; Provisional; Region: PRK15352 1160717006283 type III secretion system protein SsaP; Provisional; Region: PRK15351 1160717006284 type III secretion system protein SsaQ; Validated; Region: PRK08035 1160717006285 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1160717006286 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1160717006287 type III secretion system protein SsaS; Provisional; Region: PRK15350 1160717006288 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1160717006289 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 1160717006290 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1160717006291 multidrug efflux protein; Reviewed; Region: PRK01766 1160717006292 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1160717006293 cation binding site [ion binding]; other site 1160717006294 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1160717006295 Lumazine binding domain; Region: Lum_binding; pfam00677 1160717006296 Lumazine binding domain; Region: Lum_binding; pfam00677 1160717006297 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1160717006298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717006299 S-adenosylmethionine binding site [chemical binding]; other site 1160717006300 putative transporter; Provisional; Region: PRK11043 1160717006301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006302 putative substrate translocation pore; other site 1160717006303 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1160717006304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717006305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717006306 dimerization interface [polypeptide binding]; other site 1160717006307 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1160717006308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717006309 DNA binding site [nucleotide binding] 1160717006310 domain linker motif; other site 1160717006311 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1160717006312 dimerization interface [polypeptide binding]; other site 1160717006313 ligand binding site [chemical binding]; other site 1160717006314 superoxide dismutase; Provisional; Region: PRK10543 1160717006315 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1160717006316 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1160717006317 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1160717006318 NlpC/P60 family; Region: NLPC_P60; pfam00877 1160717006319 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1160717006320 putative GSH binding site [chemical binding]; other site 1160717006321 catalytic residues [active] 1160717006322 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1160717006323 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1160717006324 dimer interface [polypeptide binding]; other site 1160717006325 catalytic site [active] 1160717006326 putative active site [active] 1160717006327 putative substrate binding site [chemical binding]; other site 1160717006328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1160717006329 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1160717006330 dimer interface [polypeptide binding]; other site 1160717006331 active site 1160717006332 metal binding site [ion binding]; metal-binding site 1160717006333 glutathione binding site [chemical binding]; other site 1160717006334 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1160717006335 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1160717006336 FMN binding site [chemical binding]; other site 1160717006337 active site 1160717006338 substrate binding site [chemical binding]; other site 1160717006339 catalytic residue [active] 1160717006340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1160717006341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717006342 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1160717006343 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717006344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717006345 active site 1160717006346 catalytic tetrad [active] 1160717006347 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1160717006348 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1160717006349 E-class dimer interface [polypeptide binding]; other site 1160717006350 P-class dimer interface [polypeptide binding]; other site 1160717006351 active site 1160717006352 Cu2+ binding site [ion binding]; other site 1160717006353 Zn2+ binding site [ion binding]; other site 1160717006354 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1160717006355 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1160717006356 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1160717006357 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717006358 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717006359 transcriptional regulator SlyA; Provisional; Region: PRK03573 1160717006360 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1160717006361 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1160717006362 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1160717006363 lysozyme inhibitor; Provisional; Region: PRK11372 1160717006364 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1160717006365 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1160717006366 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1160717006367 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1160717006368 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1160717006369 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1160717006370 active site 1160717006371 HIGH motif; other site 1160717006372 dimer interface [polypeptide binding]; other site 1160717006373 KMSKS motif; other site 1160717006374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717006375 RNA binding surface [nucleotide binding]; other site 1160717006376 pyridoxamine kinase; Validated; Region: PRK05756 1160717006377 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1160717006378 dimer interface [polypeptide binding]; other site 1160717006379 pyridoxal binding site [chemical binding]; other site 1160717006380 ATP binding site [chemical binding]; other site 1160717006381 glutathionine S-transferase; Provisional; Region: PRK10542 1160717006382 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1160717006383 C-terminal domain interface [polypeptide binding]; other site 1160717006384 GSH binding site (G-site) [chemical binding]; other site 1160717006385 dimer interface [polypeptide binding]; other site 1160717006386 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1160717006387 dimer interface [polypeptide binding]; other site 1160717006388 N-terminal domain interface [polypeptide binding]; other site 1160717006389 substrate binding pocket (H-site) [chemical binding]; other site 1160717006390 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1160717006391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006392 putative substrate translocation pore; other site 1160717006393 POT family; Region: PTR2; pfam00854 1160717006394 endonuclease III; Provisional; Region: PRK10702 1160717006395 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1160717006396 minor groove reading motif; other site 1160717006397 helix-hairpin-helix signature motif; other site 1160717006398 substrate binding pocket [chemical binding]; other site 1160717006399 active site 1160717006400 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1160717006401 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1160717006402 electron transport complex protein RnfG; Validated; Region: PRK01908 1160717006403 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1160717006404 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1160717006405 SLBB domain; Region: SLBB; pfam10531 1160717006406 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717006407 electron transport complex protein RnfB; Provisional; Region: PRK05113 1160717006408 Putative Fe-S cluster; Region: FeS; cl17515 1160717006409 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717006410 electron transport complex protein RsxA; Provisional; Region: PRK05151 1160717006411 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1160717006412 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1160717006413 putative oxidoreductase; Provisional; Region: PRK11579 1160717006414 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1160717006415 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1160717006416 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1160717006417 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1160717006418 active site 1160717006419 purine riboside binding site [chemical binding]; other site 1160717006420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1160717006421 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1160717006422 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1160717006423 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1160717006424 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1160717006425 fumarate hydratase; Provisional; Region: PRK15389 1160717006426 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1160717006427 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1160717006428 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1160717006429 Class II fumarases; Region: Fumarase_classII; cd01362 1160717006430 active site 1160717006431 tetramer interface [polypeptide binding]; other site 1160717006432 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1160717006433 sensor protein RstB; Provisional; Region: PRK10604 1160717006434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717006435 dimerization interface [polypeptide binding]; other site 1160717006436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717006437 dimer interface [polypeptide binding]; other site 1160717006438 phosphorylation site [posttranslational modification] 1160717006439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717006440 ATP binding site [chemical binding]; other site 1160717006441 Mg2+ binding site [ion binding]; other site 1160717006442 G-X-G motif; other site 1160717006443 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1160717006444 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1160717006445 active site 1160717006446 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717006447 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717006448 trimer interface [polypeptide binding]; other site 1160717006449 eyelet of channel; other site 1160717006450 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1160717006451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717006452 active site 1160717006453 phosphorylation site [posttranslational modification] 1160717006454 intermolecular recognition site; other site 1160717006455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717006456 DNA binding site [nucleotide binding] 1160717006457 GlpM protein; Region: GlpM; pfam06942 1160717006458 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1160717006459 Spore germination protein; Region: Spore_permease; cl17796 1160717006460 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717006461 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717006462 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717006463 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1160717006464 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1160717006465 ligand binding site [chemical binding]; other site 1160717006466 homodimer interface [polypeptide binding]; other site 1160717006467 NAD(P) binding site [chemical binding]; other site 1160717006468 trimer interface B [polypeptide binding]; other site 1160717006469 trimer interface A [polypeptide binding]; other site 1160717006470 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1160717006471 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1160717006472 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1160717006473 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1160717006474 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1160717006475 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1160717006476 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1160717006477 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1160717006478 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1160717006479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006480 putative substrate translocation pore; other site 1160717006481 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1160717006482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717006483 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1160717006484 dimerization interface [polypeptide binding]; other site 1160717006485 substrate binding pocket [chemical binding]; other site 1160717006486 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1160717006487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1160717006488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717006489 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1160717006490 AAA domain; Region: AAA_26; pfam13500 1160717006491 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1160717006492 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1160717006493 Cl- selectivity filter; other site 1160717006494 Cl- binding residues [ion binding]; other site 1160717006495 pore gating glutamate residue; other site 1160717006496 dimer interface [polypeptide binding]; other site 1160717006497 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1160717006498 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1160717006499 Walker A/P-loop; other site 1160717006500 ATP binding site [chemical binding]; other site 1160717006501 Q-loop/lid; other site 1160717006502 ABC transporter signature motif; other site 1160717006503 Walker B; other site 1160717006504 D-loop; other site 1160717006505 H-loop/switch region; other site 1160717006506 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1160717006507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717006508 dimer interface [polypeptide binding]; other site 1160717006509 conserved gate region; other site 1160717006510 ABC-ATPase subunit interface; other site 1160717006511 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1160717006512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717006513 dimer interface [polypeptide binding]; other site 1160717006514 conserved gate region; other site 1160717006515 putative PBP binding loops; other site 1160717006516 ABC-ATPase subunit interface; other site 1160717006517 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1160717006518 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1160717006519 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1160717006520 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717006521 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1160717006522 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1160717006523 putative [Fe4-S4] binding site [ion binding]; other site 1160717006524 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717006525 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1160717006526 putative molybdopterin cofactor binding site; other site 1160717006527 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1160717006528 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1160717006529 putative [Fe4-S4] binding site [ion binding]; other site 1160717006530 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717006531 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1160717006532 putative molybdopterin cofactor binding site; other site 1160717006533 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1160717006534 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1160717006535 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1160717006536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717006537 Coenzyme A binding pocket [chemical binding]; other site 1160717006538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1160717006539 hypothetical protein; Provisional; Region: PRK13659 1160717006540 hypothetical protein; Provisional; Region: PRK02237 1160717006541 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1160717006542 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1160717006543 putative active site pocket [active] 1160717006544 putative metal binding site [ion binding]; other site 1160717006545 putative oxidoreductase; Provisional; Region: PRK10083 1160717006546 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1160717006547 putative NAD(P) binding site [chemical binding]; other site 1160717006548 catalytic Zn binding site [ion binding]; other site 1160717006549 structural Zn binding site [ion binding]; other site 1160717006550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006551 metabolite-proton symporter; Region: 2A0106; TIGR00883 1160717006552 putative substrate translocation pore; other site 1160717006553 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1160717006554 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1160717006555 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1160717006556 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1160717006557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717006558 DNA-binding site [nucleotide binding]; DNA binding site 1160717006559 FCD domain; Region: FCD; pfam07729 1160717006560 malonic semialdehyde reductase; Provisional; Region: PRK10538 1160717006561 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1160717006562 putative NAD(P) binding site [chemical binding]; other site 1160717006563 homodimer interface [polypeptide binding]; other site 1160717006564 homotetramer interface [polypeptide binding]; other site 1160717006565 active site 1160717006566 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1160717006567 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1160717006568 active site 1160717006569 Zn binding site [ion binding]; other site 1160717006570 General stress protein [General function prediction only]; Region: GsiB; COG3729 1160717006571 hypothetical protein; Validated; Region: PRK03657 1160717006572 hypothetical protein; Provisional; Region: PRK10053 1160717006573 putative transporter; Provisional; Region: PRK10054 1160717006574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006575 putative substrate translocation pore; other site 1160717006576 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1160717006577 EamA-like transporter family; Region: EamA; pfam00892 1160717006578 MarB protein; Region: MarB; pfam13999 1160717006579 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1160717006580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717006581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717006582 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1160717006583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1160717006584 inner membrane protein; Provisional; Region: PRK10995 1160717006585 putative arabinose transporter; Provisional; Region: PRK03545 1160717006586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006587 putative substrate translocation pore; other site 1160717006588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717006589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717006590 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1160717006591 putative dimerization interface [polypeptide binding]; other site 1160717006592 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1160717006593 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1160717006594 NAD(P) binding site [chemical binding]; other site 1160717006595 catalytic residues [active] 1160717006596 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1160717006597 glutaminase; Provisional; Region: PRK00971 1160717006598 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1160717006599 Predicted membrane protein [Function unknown]; Region: COG3781 1160717006600 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1160717006601 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717006602 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717006603 trimer interface [polypeptide binding]; other site 1160717006604 eyelet of channel; other site 1160717006605 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1160717006606 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1160717006607 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1160717006608 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1160717006609 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1160717006610 Rubredoxin [Energy production and conversion]; Region: COG1773 1160717006611 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1160717006612 iron binding site [ion binding]; other site 1160717006613 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1160717006614 HupF/HypC family; Region: HupF_HypC; cl00394 1160717006615 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1160717006616 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1160717006617 putative substrate-binding site; other site 1160717006618 nickel binding site [ion binding]; other site 1160717006619 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1160717006620 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1160717006621 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1160717006622 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1160717006623 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1160717006624 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1160717006625 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1160717006626 active site 1160717006627 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1160717006628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717006629 DNA-binding site [nucleotide binding]; DNA binding site 1160717006630 FCD domain; Region: FCD; pfam07729 1160717006631 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1160717006632 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1160717006633 putative NAD(P) binding site [chemical binding]; other site 1160717006634 catalytic Zn binding site [ion binding]; other site 1160717006635 structural Zn binding site [ion binding]; other site 1160717006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006637 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717006638 putative substrate translocation pore; other site 1160717006639 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 1160717006640 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1160717006641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717006643 putative substrate translocation pore; other site 1160717006644 hypothetical protein; Provisional; Region: PRK06184 1160717006645 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1160717006646 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1160717006647 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1160717006648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717006649 putative DNA binding site [nucleotide binding]; other site 1160717006650 putative Zn2+ binding site [ion binding]; other site 1160717006651 genomic island 1160717006652 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1160717006653 homotrimer interaction site [polypeptide binding]; other site 1160717006654 putative active site [active] 1160717006655 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1160717006656 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1160717006657 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1160717006658 Winged helix-turn helix; Region: HTH_29; pfam13551 1160717006659 Helix-turn-helix domain; Region: HTH_28; pfam13518 1160717006660 Homeodomain-like domain; Region: HTH_32; pfam13565 1160717006661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717006662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717006663 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1160717006664 putative effector binding pocket; other site 1160717006665 putative dimerization interface [polypeptide binding]; other site 1160717006666 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1160717006667 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1160717006668 FMN binding site [chemical binding]; other site 1160717006669 substrate binding site [chemical binding]; other site 1160717006670 putative catalytic residue [active] 1160717006671 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1160717006672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717006673 DNA binding site [nucleotide binding] 1160717006674 domain linker motif; other site 1160717006675 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1160717006676 dimerization interface (closed form) [polypeptide binding]; other site 1160717006677 ligand binding site [chemical binding]; other site 1160717006678 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1160717006679 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1160717006680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717006681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717006682 homodimer interface [polypeptide binding]; other site 1160717006683 catalytic residue [active] 1160717006684 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1160717006685 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1160717006686 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1160717006687 active site 1160717006688 catalytic site [active] 1160717006689 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1160717006690 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1160717006691 active site 1160717006692 catalytic site [active] 1160717006693 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1160717006694 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1160717006695 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1160717006696 catalytic site [active] 1160717006697 active site 1160717006698 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1160717006699 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1160717006700 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1160717006701 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1160717006702 biofilm-dependent modulation protein; Provisional; Region: PRK11436 1160717006703 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1160717006704 malate dehydrogenase; Provisional; Region: PRK13529 1160717006705 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1160717006706 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1160717006707 NAD(P) binding site [chemical binding]; other site 1160717006708 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1160717006709 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1160717006710 NAD binding site [chemical binding]; other site 1160717006711 substrate binding site [chemical binding]; other site 1160717006712 catalytic Zn binding site [ion binding]; other site 1160717006713 tetramer interface [polypeptide binding]; other site 1160717006714 structural Zn binding site [ion binding]; other site 1160717006715 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1160717006716 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1160717006717 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1160717006718 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1160717006719 aromatic amino acid exporter; Provisional; Region: PRK11689 1160717006720 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717006721 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717006722 trimer interface [polypeptide binding]; other site 1160717006723 eyelet of channel; other site 1160717006724 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1160717006725 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1160717006726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717006727 putative substrate translocation pore; other site 1160717006728 TetR family transcriptional regulator; Provisional; Region: PRK14996 1160717006729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717006730 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1160717006731 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1160717006732 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1160717006733 [4Fe-4S] binding site [ion binding]; other site 1160717006734 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717006735 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717006736 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717006737 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1160717006738 molybdopterin cofactor binding site; other site 1160717006739 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1160717006740 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1160717006741 hypothetical protein; Provisional; Region: PRK10281 1160717006742 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1160717006743 L-asparagine permease; Provisional; Region: PRK15049 1160717006744 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1160717006745 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1160717006746 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1160717006747 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1160717006748 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1160717006749 N-terminal plug; other site 1160717006750 ligand-binding site [chemical binding]; other site 1160717006751 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1160717006752 DNA-binding site [nucleotide binding]; DNA binding site 1160717006753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1160717006754 FCD domain; Region: FCD; pfam07729 1160717006755 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1160717006756 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1160717006757 NAD(P) binding site [chemical binding]; other site 1160717006758 substrate binding site [chemical binding]; other site 1160717006759 dimer interface [polypeptide binding]; other site 1160717006760 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1160717006761 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1160717006762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1160717006763 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1160717006764 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1160717006765 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1160717006766 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1160717006767 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1160717006768 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1160717006769 tetrameric interface [polypeptide binding]; other site 1160717006770 NAD binding site [chemical binding]; other site 1160717006771 catalytic residues [active] 1160717006772 substrate binding site [chemical binding]; other site 1160717006773 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1160717006774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717006775 DNA-binding site [nucleotide binding]; DNA binding site 1160717006776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717006777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717006778 homodimer interface [polypeptide binding]; other site 1160717006779 catalytic residue [active] 1160717006780 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1160717006781 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 1160717006782 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1160717006783 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1160717006784 Peptidase family U32; Region: Peptidase_U32; pfam01136 1160717006785 Collagenase; Region: DUF3656; pfam12392 1160717006786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1160717006787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717006788 non-specific DNA binding site [nucleotide binding]; other site 1160717006789 salt bridge; other site 1160717006790 sequence-specific DNA binding site [nucleotide binding]; other site 1160717006791 Cupin domain; Region: Cupin_2; pfam07883 1160717006792 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1160717006793 benzoate transporter; Region: benE; TIGR00843 1160717006794 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1160717006795 tellurite resistance protein TehB; Provisional; Region: PRK11207 1160717006796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717006797 S-adenosylmethionine binding site [chemical binding]; other site 1160717006798 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1160717006799 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1160717006800 gating phenylalanine in ion channel; other site 1160717006801 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1160717006802 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1160717006803 putative trimer interface [polypeptide binding]; other site 1160717006804 putative CoA binding site [chemical binding]; other site 1160717006805 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1160717006806 putative trimer interface [polypeptide binding]; other site 1160717006807 putative CoA binding site [chemical binding]; other site 1160717006808 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1160717006809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717006810 Coenzyme A binding pocket [chemical binding]; other site 1160717006811 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1160717006812 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1160717006813 oligomer interface [polypeptide binding]; other site 1160717006814 active site 1160717006815 metal binding site [ion binding]; metal-binding site 1160717006816 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1160717006817 active site 1160717006818 P-loop; other site 1160717006819 phosphorylation site [posttranslational modification] 1160717006820 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1160717006821 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1160717006822 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1160717006823 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717006824 active site 1160717006825 phosphorylation site [posttranslational modification] 1160717006826 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1160717006827 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1160717006828 substrate binding site [chemical binding]; other site 1160717006829 hexamer interface [polypeptide binding]; other site 1160717006830 metal binding site [ion binding]; metal-binding site 1160717006831 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717006832 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1160717006833 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717006834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717006835 Coenzyme A binding pocket [chemical binding]; other site 1160717006836 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1160717006837 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1160717006838 teramer interface [polypeptide binding]; other site 1160717006839 active site 1160717006840 FMN binding site [chemical binding]; other site 1160717006841 catalytic residues [active] 1160717006842 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1160717006843 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1160717006844 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1160717006845 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1160717006846 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1160717006847 substrate binding pocket [chemical binding]; other site 1160717006848 catalytic triad [active] 1160717006849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1160717006850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1160717006851 genomic island 1160717006852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717006853 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1160717006854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717006855 dimerization interface [polypeptide binding]; other site 1160717006856 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1160717006857 dimer interface [polypeptide binding]; other site 1160717006858 ligand binding site [chemical binding]; other site 1160717006859 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1160717006860 HAMP domain; Region: HAMP; pfam00672 1160717006861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717006862 dimer interface [polypeptide binding]; other site 1160717006863 putative CheW interface [polypeptide binding]; other site 1160717006864 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1160717006865 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1160717006866 substrate binding site [chemical binding]; other site 1160717006867 catalytic Zn binding site [ion binding]; other site 1160717006868 NAD binding site [chemical binding]; other site 1160717006869 structural Zn binding site [ion binding]; other site 1160717006870 dimer interface [polypeptide binding]; other site 1160717006871 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1160717006872 putative metal binding site [ion binding]; other site 1160717006873 putative homodimer interface [polypeptide binding]; other site 1160717006874 putative homotetramer interface [polypeptide binding]; other site 1160717006875 putative homodimer-homodimer interface [polypeptide binding]; other site 1160717006876 putative allosteric switch controlling residues; other site 1160717006877 Sif protein; Region: Sif; cl11505 1160717006878 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1160717006879 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1160717006880 active site 1160717006881 catalytic triad [active] 1160717006882 oxyanion hole [active] 1160717006883 Predicted membrane protein [Function unknown]; Region: COG3326 1160717006884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717006885 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1160717006886 substrate binding pocket [chemical binding]; other site 1160717006887 membrane-bound complex binding site; other site 1160717006888 hinge residues; other site 1160717006889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1160717006890 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1160717006891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717006892 Walker A/P-loop; other site 1160717006893 ATP binding site [chemical binding]; other site 1160717006894 Q-loop/lid; other site 1160717006895 ABC transporter signature motif; other site 1160717006896 Walker B; other site 1160717006897 D-loop; other site 1160717006898 H-loop/switch region; other site 1160717006899 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717006900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717006901 dimer interface [polypeptide binding]; other site 1160717006902 conserved gate region; other site 1160717006903 putative PBP binding loops; other site 1160717006904 ABC-ATPase subunit interface; other site 1160717006905 Predicted membrane protein [Function unknown]; Region: COG5305 1160717006906 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1160717006907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717006908 S-adenosylmethionine binding site [chemical binding]; other site 1160717006909 cytochrome b561; Provisional; Region: PRK11513 1160717006910 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1160717006911 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1160717006912 putative active site [active] 1160717006913 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1160717006914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717006915 ATP binding site [chemical binding]; other site 1160717006916 putative Mg++ binding site [ion binding]; other site 1160717006917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717006918 nucleotide binding region [chemical binding]; other site 1160717006919 ATP-binding site [chemical binding]; other site 1160717006920 Helicase associated domain (HA2); Region: HA2; pfam04408 1160717006921 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1160717006922 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1160717006923 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1160717006924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1160717006925 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1160717006926 Dicarboxylate transport; Region: DctA-YdbH; cl14674 1160717006927 Dicarboxylate transport; Region: DctA-YdbH; cl14674 1160717006928 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1160717006929 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1160717006930 putative ligand binding site [chemical binding]; other site 1160717006931 putative NAD binding site [chemical binding]; other site 1160717006932 catalytic site [active] 1160717006933 heat-inducible protein; Provisional; Region: PRK10449 1160717006934 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1160717006935 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1160717006936 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1160717006937 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1160717006938 dimer interface [polypeptide binding]; other site 1160717006939 PYR/PP interface [polypeptide binding]; other site 1160717006940 TPP binding site [chemical binding]; other site 1160717006941 substrate binding site [chemical binding]; other site 1160717006942 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1160717006943 Domain of unknown function; Region: EKR; smart00890 1160717006944 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1160717006945 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717006946 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1160717006947 TPP-binding site [chemical binding]; other site 1160717006948 dimer interface [polypeptide binding]; other site 1160717006949 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1160717006950 Ligand Binding Site [chemical binding]; other site 1160717006951 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1160717006952 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1160717006953 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1160717006954 Ligand Binding Site [chemical binding]; other site 1160717006955 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1160717006956 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1160717006957 ATP binding site [chemical binding]; other site 1160717006958 Mg++ binding site [ion binding]; other site 1160717006959 motif III; other site 1160717006960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717006961 nucleotide binding region [chemical binding]; other site 1160717006962 ATP-binding site [chemical binding]; other site 1160717006963 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1160717006964 putative RNA binding site [nucleotide binding]; other site 1160717006965 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1160717006966 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1160717006967 Cl binding site [ion binding]; other site 1160717006968 oligomer interface [polypeptide binding]; other site 1160717006969 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1160717006970 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717006971 dimer interface [polypeptide binding]; other site 1160717006972 putative CheW interface [polypeptide binding]; other site 1160717006973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1160717006974 Smr domain; Region: Smr; pfam01713 1160717006975 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1160717006976 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1160717006977 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1160717006978 DNA binding site [nucleotide binding] 1160717006979 active site 1160717006980 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1160717006981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1160717006982 ligand binding site [chemical binding]; other site 1160717006983 flexible hinge region; other site 1160717006984 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1160717006985 putative switch regulator; other site 1160717006986 non-specific DNA interactions [nucleotide binding]; other site 1160717006987 DNA binding site [nucleotide binding] 1160717006988 sequence specific DNA binding site [nucleotide binding]; other site 1160717006989 putative cAMP binding site [chemical binding]; other site 1160717006990 universal stress protein UspE; Provisional; Region: PRK11175 1160717006991 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1160717006992 Ligand Binding Site [chemical binding]; other site 1160717006993 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1160717006994 Ligand Binding Site [chemical binding]; other site 1160717006995 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1160717006996 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1160717006997 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717006998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717006999 sequence-specific DNA binding site [nucleotide binding]; other site 1160717007000 salt bridge; other site 1160717007001 Cupin domain; Region: Cupin_2; pfam07883 1160717007002 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1160717007003 B3/4 domain; Region: B3_4; pfam03483 1160717007004 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1160717007005 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1160717007006 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1160717007007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717007008 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1160717007009 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1160717007010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1160717007011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717007012 oxidoreductase; Provisional; Region: PRK12742 1160717007013 classical (c) SDRs; Region: SDR_c; cd05233 1160717007014 NAD(P) binding site [chemical binding]; other site 1160717007015 active site 1160717007016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717007017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717007018 active site 1160717007019 catalytic tetrad [active] 1160717007020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717007021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717007022 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1160717007023 putative effector binding pocket; other site 1160717007024 putative dimerization interface [polypeptide binding]; other site 1160717007025 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1160717007026 NmrA-like family; Region: NmrA; pfam05368 1160717007027 NAD(P) binding site [chemical binding]; other site 1160717007028 active site lysine 1160717007029 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1160717007030 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1160717007031 peptide binding site [polypeptide binding]; other site 1160717007032 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1160717007033 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1160717007034 putative active site [active] 1160717007035 Zn binding site [ion binding]; other site 1160717007036 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1160717007037 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1160717007038 active site 1160717007039 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1160717007040 dimer interface [polypeptide binding]; other site 1160717007041 catalytic triad [active] 1160717007042 peroxidatic and resolving cysteines [active] 1160717007043 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1160717007044 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1160717007045 putative aromatic amino acid binding site; other site 1160717007046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717007047 Walker A motif; other site 1160717007048 ATP binding site [chemical binding]; other site 1160717007049 Walker B motif; other site 1160717007050 arginine finger; other site 1160717007051 hypothetical protein; Provisional; Region: PRK05415 1160717007052 TIGR01620 family protein; Region: hyp_HI0043 1160717007053 Predicted ATPase [General function prediction only]; Region: COG3106 1160717007054 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1160717007055 active site residue [active] 1160717007056 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1160717007057 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1160717007058 phage shock protein C; Region: phageshock_pspC; TIGR02978 1160717007059 phage shock protein B; Provisional; Region: pspB; PRK09458 1160717007060 phage shock protein PspA; Provisional; Region: PRK10698 1160717007061 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1160717007062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717007063 Walker A motif; other site 1160717007064 ATP binding site [chemical binding]; other site 1160717007065 Walker B motif; other site 1160717007066 arginine finger; other site 1160717007067 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1160717007068 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1160717007069 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1160717007070 peptide binding site [polypeptide binding]; other site 1160717007071 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1160717007072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717007073 dimer interface [polypeptide binding]; other site 1160717007074 conserved gate region; other site 1160717007075 putative PBP binding loops; other site 1160717007076 ABC-ATPase subunit interface; other site 1160717007077 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1160717007078 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1160717007079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717007080 dimer interface [polypeptide binding]; other site 1160717007081 conserved gate region; other site 1160717007082 putative PBP binding loops; other site 1160717007083 ABC-ATPase subunit interface; other site 1160717007084 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1160717007085 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717007086 Walker A/P-loop; other site 1160717007087 ATP binding site [chemical binding]; other site 1160717007088 Q-loop/lid; other site 1160717007089 ABC transporter signature motif; other site 1160717007090 Walker B; other site 1160717007091 D-loop; other site 1160717007092 H-loop/switch region; other site 1160717007093 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1160717007094 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1160717007095 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717007096 Walker A/P-loop; other site 1160717007097 ATP binding site [chemical binding]; other site 1160717007098 Q-loop/lid; other site 1160717007099 ABC transporter signature motif; other site 1160717007100 Walker B; other site 1160717007101 D-loop; other site 1160717007102 H-loop/switch region; other site 1160717007103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1160717007104 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1160717007105 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1160717007106 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1160717007107 NAD binding site [chemical binding]; other site 1160717007108 homotetramer interface [polypeptide binding]; other site 1160717007109 homodimer interface [polypeptide binding]; other site 1160717007110 substrate binding site [chemical binding]; other site 1160717007111 active site 1160717007112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1160717007113 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1160717007114 exoribonuclease II; Provisional; Region: PRK05054 1160717007115 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1160717007116 RNB domain; Region: RNB; pfam00773 1160717007117 S1 RNA binding domain; Region: S1; pfam00575 1160717007118 RNase II stability modulator; Provisional; Region: PRK10060 1160717007119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717007120 putative active site [active] 1160717007121 heme pocket [chemical binding]; other site 1160717007122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717007123 metal binding site [ion binding]; metal-binding site 1160717007124 active site 1160717007125 I-site; other site 1160717007126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717007127 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717007128 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717007129 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717007130 lipoprotein; Provisional; Region: PRK10540 1160717007131 translation initiation factor Sui1; Validated; Region: PRK06824 1160717007132 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1160717007133 putative rRNA binding site [nucleotide binding]; other site 1160717007134 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1160717007135 active site 1160717007136 dimer interface [polypeptide binding]; other site 1160717007137 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1160717007138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1160717007139 TPR motif; other site 1160717007140 binding surface 1160717007141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1160717007142 binding surface 1160717007143 TPR motif; other site 1160717007144 Predicted membrane protein [Function unknown]; Region: COG3771 1160717007145 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1160717007146 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1160717007147 active site 1160717007148 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1160717007149 dimerization interface [polypeptide binding]; other site 1160717007150 active site 1160717007151 aconitate hydratase; Validated; Region: PRK09277 1160717007152 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1160717007153 substrate binding site [chemical binding]; other site 1160717007154 ligand binding site [chemical binding]; other site 1160717007155 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1160717007156 substrate binding site [chemical binding]; other site 1160717007157 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1160717007158 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1160717007159 substrate binding site [chemical binding]; other site 1160717007160 putative dimerization interface [polypeptide binding]; other site 1160717007161 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1160717007162 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1160717007163 active site 1160717007164 interdomain interaction site; other site 1160717007165 putative metal-binding site [ion binding]; other site 1160717007166 nucleotide binding site [chemical binding]; other site 1160717007167 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1160717007168 domain I; other site 1160717007169 DNA binding groove [nucleotide binding] 1160717007170 phosphate binding site [ion binding]; other site 1160717007171 domain II; other site 1160717007172 domain III; other site 1160717007173 nucleotide binding site [chemical binding]; other site 1160717007174 catalytic site [active] 1160717007175 domain IV; other site 1160717007176 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1160717007177 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1160717007178 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1160717007179 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1160717007180 hypothetical protein; Provisional; Region: PRK11037 1160717007181 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1160717007182 putative inner membrane peptidase; Provisional; Region: PRK11778 1160717007183 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1160717007184 tandem repeat interface [polypeptide binding]; other site 1160717007185 oligomer interface [polypeptide binding]; other site 1160717007186 active site residues [active] 1160717007187 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1160717007188 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1160717007189 NADP binding site [chemical binding]; other site 1160717007190 homodimer interface [polypeptide binding]; other site 1160717007191 active site 1160717007192 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1160717007193 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1160717007194 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1160717007195 homodimer interface [polypeptide binding]; other site 1160717007196 Walker A motif; other site 1160717007197 ATP binding site [chemical binding]; other site 1160717007198 hydroxycobalamin binding site [chemical binding]; other site 1160717007199 Walker B motif; other site 1160717007200 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1160717007201 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717007202 RNA binding surface [nucleotide binding]; other site 1160717007203 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1160717007204 probable active site [active] 1160717007205 hypothetical protein; Provisional; Region: PRK11630 1160717007206 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1160717007207 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1160717007208 active site 1160717007209 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1160717007210 Trp_leader; SU5_nc79 1160717007211 anthranilate synthase component I; Provisional; Region: PRK13564 1160717007212 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1160717007213 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1160717007214 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1160717007215 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1160717007216 glutamine binding [chemical binding]; other site 1160717007217 catalytic triad [active] 1160717007218 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1160717007219 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1160717007220 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1160717007221 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1160717007222 active site 1160717007223 ribulose/triose binding site [chemical binding]; other site 1160717007224 phosphate binding site [ion binding]; other site 1160717007225 substrate (anthranilate) binding pocket [chemical binding]; other site 1160717007226 product (indole) binding pocket [chemical binding]; other site 1160717007227 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1160717007228 active site 1160717007229 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1160717007230 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1160717007231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717007232 catalytic residue [active] 1160717007233 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1160717007234 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1160717007235 substrate binding site [chemical binding]; other site 1160717007236 active site 1160717007237 catalytic residues [active] 1160717007238 heterodimer interface [polypeptide binding]; other site 1160717007239 General stress protein [General function prediction only]; Region: GsiB; COG3729 1160717007240 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1160717007241 dimerization interface [polypeptide binding]; other site 1160717007242 metal binding site [ion binding]; metal-binding site 1160717007243 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1160717007244 dinuclear metal binding motif [ion binding]; other site 1160717007245 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1160717007246 dimanganese center [ion binding]; other site 1160717007247 outer membrane protein W; Provisional; Region: PRK10959 1160717007248 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1160717007249 hypothetical protein; Provisional; Region: PRK02868 1160717007250 intracellular septation protein A; Reviewed; Region: PRK00259 1160717007251 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1160717007252 transport protein TonB; Provisional; Region: PRK10819 1160717007253 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1160717007254 YciI-like protein; Reviewed; Region: PRK11370 1160717007255 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1160717007256 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1160717007257 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1160717007258 putative active site [active] 1160717007259 catalytic site [active] 1160717007260 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1160717007261 putative active site [active] 1160717007262 catalytic site [active] 1160717007263 putative phage 1160717007264 dsDNA-mimic protein; Reviewed; Region: PRK05094 1160717007265 Ion transport protein; Region: Ion_trans; pfam00520 1160717007266 Ion channel; Region: Ion_trans_2; pfam07885 1160717007267 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1160717007268 Double zinc ribbon; Region: DZR; pfam12773 1160717007269 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1160717007270 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717007271 Walker A/P-loop; other site 1160717007272 ATP binding site [chemical binding]; other site 1160717007273 Q-loop/lid; other site 1160717007274 ABC transporter signature motif; other site 1160717007275 Walker B; other site 1160717007276 D-loop; other site 1160717007277 H-loop/switch region; other site 1160717007278 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1160717007279 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1160717007280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717007281 Walker A/P-loop; other site 1160717007282 ATP binding site [chemical binding]; other site 1160717007283 Q-loop/lid; other site 1160717007284 ABC transporter signature motif; other site 1160717007285 Walker B; other site 1160717007286 D-loop; other site 1160717007287 H-loop/switch region; other site 1160717007288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1160717007289 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1160717007290 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1160717007291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717007292 dimer interface [polypeptide binding]; other site 1160717007293 conserved gate region; other site 1160717007294 ABC-ATPase subunit interface; other site 1160717007295 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1160717007296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717007297 dimer interface [polypeptide binding]; other site 1160717007298 conserved gate region; other site 1160717007299 putative PBP binding loops; other site 1160717007300 ABC-ATPase subunit interface; other site 1160717007301 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1160717007302 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1160717007303 peptide binding site [polypeptide binding]; other site 1160717007304 hypothetical protein; Provisional; Region: PRK11111 1160717007305 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1160717007306 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1160717007307 putative catalytic cysteine [active] 1160717007308 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1160717007309 putative active site [active] 1160717007310 metal binding site [ion binding]; metal-binding site 1160717007311 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1160717007312 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1160717007313 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1160717007314 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1160717007315 active site 1160717007316 tetramer interface; other site 1160717007317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717007318 active site 1160717007319 response regulator of RpoS; Provisional; Region: PRK10693 1160717007320 phosphorylation site [posttranslational modification] 1160717007321 intermolecular recognition site; other site 1160717007322 dimerization interface [polypeptide binding]; other site 1160717007323 hypothetical protein; Provisional; Region: PRK10279 1160717007324 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1160717007325 active site 1160717007326 nucleophile elbow; other site 1160717007327 hypothetical protein; Provisional; Region: PRK01617 1160717007328 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1160717007329 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1160717007330 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1160717007331 putative active site [active] 1160717007332 putative substrate binding site [chemical binding]; other site 1160717007333 putative cosubstrate binding site; other site 1160717007334 catalytic site [active] 1160717007335 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717007336 Sel1-like repeats; Region: SEL1; smart00671 1160717007337 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717007338 Sel1-like repeats; Region: SEL1; smart00671 1160717007339 Sel1-like repeats; Region: SEL1; smart00671 1160717007340 Sel1-like repeats; Region: SEL1; smart00671 1160717007341 Sel1-like repeats; Region: SEL1; smart00671 1160717007342 Sel1-like repeats; Region: SEL1; smart00671 1160717007343 Sel1-like repeats; Region: SEL1; smart00671 1160717007344 Sel1-like repeats; Region: SEL1; smart00671 1160717007345 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1160717007346 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1160717007347 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1160717007348 4Fe-4S binding domain; Region: Fer4; cl02805 1160717007349 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1160717007350 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1160717007351 [4Fe-4S] binding site [ion binding]; other site 1160717007352 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717007353 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717007354 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717007355 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1160717007356 molybdopterin cofactor binding site; other site 1160717007357 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1160717007358 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1160717007359 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1160717007360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717007361 dimerization interface [polypeptide binding]; other site 1160717007362 Histidine kinase; Region: HisKA_3; pfam07730 1160717007363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717007364 ATP binding site [chemical binding]; other site 1160717007365 Mg2+ binding site [ion binding]; other site 1160717007366 G-X-G motif; other site 1160717007367 transcriptional regulator NarL; Provisional; Region: PRK10651 1160717007368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717007369 active site 1160717007370 phosphorylation site [posttranslational modification] 1160717007371 intermolecular recognition site; other site 1160717007372 dimerization interface [polypeptide binding]; other site 1160717007373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717007374 DNA binding residues [nucleotide binding] 1160717007375 dimerization interface [polypeptide binding]; other site 1160717007376 putative invasin; Provisional; Region: PRK10177 1160717007377 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1160717007378 cation transport regulator; Reviewed; Region: chaB; PRK09582 1160717007379 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1160717007380 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1160717007381 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1160717007382 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1160717007383 hypothetical protein; Provisional; Region: PRK10941 1160717007384 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1160717007385 hypothetical protein; Provisional; Region: PRK10278 1160717007386 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1160717007387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717007388 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1160717007389 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1160717007390 RF-1 domain; Region: RF-1; pfam00472 1160717007391 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1160717007392 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1160717007393 tRNA; other site 1160717007394 putative tRNA binding site [nucleotide binding]; other site 1160717007395 putative NADP binding site [chemical binding]; other site 1160717007396 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1160717007397 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1160717007398 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1160717007399 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1160717007400 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1160717007401 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1160717007402 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1160717007403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717007404 active site 1160717007405 putative transporter; Provisional; Region: PRK11660 1160717007406 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1160717007407 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1160717007408 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1160717007409 hypothetical protein; Provisional; Region: PRK10692 1160717007410 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1160717007411 putative active site [active] 1160717007412 catalytic residue [active] 1160717007413 GTP-binding protein YchF; Reviewed; Region: PRK09601 1160717007414 YchF GTPase; Region: YchF; cd01900 1160717007415 G1 box; other site 1160717007416 GTP/Mg2+ binding site [chemical binding]; other site 1160717007417 Switch I region; other site 1160717007418 G2 box; other site 1160717007419 Switch II region; other site 1160717007420 G3 box; other site 1160717007421 G4 box; other site 1160717007422 G5 box; other site 1160717007423 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1160717007424 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1160717007425 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1160717007426 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1160717007427 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1160717007428 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1160717007429 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1160717007430 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1160717007431 putative substrate-binding site; other site 1160717007432 nickel binding site [ion binding]; other site 1160717007433 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1160717007434 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1160717007435 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1160717007436 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1160717007437 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1160717007438 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1160717007439 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1160717007440 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1160717007441 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1160717007442 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1160717007443 NAD(P) binding site [chemical binding]; other site 1160717007444 trehalase; Provisional; Region: treA; PRK13271 1160717007445 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1160717007446 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1160717007447 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1160717007448 Flagellar regulator YcgR; Region: YcgR; pfam07317 1160717007449 PilZ domain; Region: PilZ; pfam07238 1160717007450 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1160717007451 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717007452 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717007453 catalytic residue [active] 1160717007454 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1160717007455 dimer interface [polypeptide binding]; other site 1160717007456 catalytic triad [active] 1160717007457 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1160717007458 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1160717007459 TrkA-C domain; Region: TrkA_C; pfam02080 1160717007460 Transporter associated domain; Region: CorC_HlyC; smart01091 1160717007461 alanine racemase; Reviewed; Region: dadX; PRK03646 1160717007462 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1160717007463 active site 1160717007464 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717007465 substrate binding site [chemical binding]; other site 1160717007466 catalytic residues [active] 1160717007467 dimer interface [polypeptide binding]; other site 1160717007468 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1160717007469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1160717007470 SpoVR family protein; Provisional; Region: PRK11767 1160717007471 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1160717007472 fatty acid metabolism regulator; Provisional; Region: PRK04984 1160717007473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717007474 DNA-binding site [nucleotide binding]; DNA binding site 1160717007475 FadR C-terminal domain; Region: FadR_C; pfam07840 1160717007476 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1160717007477 transmembrane helices; other site 1160717007478 disulfide bond formation protein B; Provisional; Region: PRK01749 1160717007479 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1160717007480 GnsA/GnsB family; Region: GnsAB; pfam08178 1160717007481 hypothetical protein; Provisional; Region: PRK05170 1160717007482 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1160717007483 hypothetical protein; Provisional; Region: PRK10691 1160717007484 YcgL domain; Region: YcgL; cl01189 1160717007485 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1160717007486 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1160717007487 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1160717007488 cell division inhibitor MinD; Provisional; Region: PRK10818 1160717007489 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1160717007490 Switch I; other site 1160717007491 Switch II; other site 1160717007492 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1160717007493 ribonuclease D; Provisional; Region: PRK10829 1160717007494 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1160717007495 catalytic site [active] 1160717007496 putative active site [active] 1160717007497 putative substrate binding site [chemical binding]; other site 1160717007498 HRDC domain; Region: HRDC; cl02578 1160717007499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1160717007500 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1160717007501 acyl-activating enzyme (AAE) consensus motif; other site 1160717007502 putative AMP binding site [chemical binding]; other site 1160717007503 putative active site [active] 1160717007504 putative CoA binding site [chemical binding]; other site 1160717007505 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1160717007506 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1160717007507 Glycoprotease family; Region: Peptidase_M22; pfam00814 1160717007508 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1160717007509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1160717007510 DEAD_2; Region: DEAD_2; pfam06733 1160717007511 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1160717007512 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1160717007513 homotrimer interaction site [polypeptide binding]; other site 1160717007514 putative active site [active] 1160717007515 hypothetical protein; Provisional; Region: PRK05114 1160717007516 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1160717007517 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1160717007518 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1160717007519 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1160717007520 putative active site [active] 1160717007521 putative CoA binding site [chemical binding]; other site 1160717007522 nudix motif; other site 1160717007523 metal binding site [ion binding]; metal-binding site 1160717007524 L-serine deaminase; Provisional; Region: PRK15023 1160717007525 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1160717007526 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1160717007527 phage resistance protein; Provisional; Region: PRK10551 1160717007528 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1160717007529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717007530 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1160717007531 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1160717007532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1160717007533 Transporter associated domain; Region: CorC_HlyC; smart01091 1160717007534 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1160717007535 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717007536 active pocket/dimerization site; other site 1160717007537 active site 1160717007538 phosphorylation site [posttranslational modification] 1160717007539 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1160717007540 active site 1160717007541 phosphorylation site [posttranslational modification] 1160717007542 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1160717007543 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1160717007544 hypothetical protein; Provisional; Region: PRK02913 1160717007545 hypothetical protein; Provisional; Region: PRK11469 1160717007546 Domain of unknown function DUF; Region: DUF204; pfam02659 1160717007547 Domain of unknown function DUF; Region: DUF204; pfam02659 1160717007548 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1160717007549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717007550 S-adenosylmethionine binding site [chemical binding]; other site 1160717007551 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1160717007552 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1160717007553 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1160717007554 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1160717007555 DNA-binding site [nucleotide binding]; DNA binding site 1160717007556 RNA-binding motif; other site 1160717007557 YebO-like protein; Region: YebO; pfam13974 1160717007558 PhoPQ regulatory protein; Provisional; Region: PRK10299 1160717007559 YobH-like protein; Region: YobH; pfam13996 1160717007560 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1160717007561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717007562 dimerization interface [polypeptide binding]; other site 1160717007563 putative Zn2+ binding site [ion binding]; other site 1160717007564 putative DNA binding site [nucleotide binding]; other site 1160717007565 Bacterial transcriptional regulator; Region: IclR; pfam01614 1160717007566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717007567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717007568 putative substrate translocation pore; other site 1160717007569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717007570 heat shock protein HtpX; Provisional; Region: PRK05457 1160717007571 carboxy-terminal protease; Provisional; Region: PRK11186 1160717007572 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1160717007573 protein binding site [polypeptide binding]; other site 1160717007574 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1160717007575 Catalytic dyad [active] 1160717007576 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1160717007577 ProP expression regulator; Provisional; Region: PRK04950 1160717007578 ProQ/FINO family; Region: ProQ; pfam04352 1160717007579 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1160717007580 GAF domain; Region: GAF_2; pfam13185 1160717007581 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1160717007582 Paraquat-inducible protein A; Region: PqiA; pfam04403 1160717007583 Paraquat-inducible protein A; Region: PqiA; pfam04403 1160717007584 genomic island 1160717007585 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1160717007586 mce related protein; Region: MCE; pfam02470 1160717007587 mce related protein; Region: MCE; pfam02470 1160717007588 mce related protein; Region: MCE; pfam02470 1160717007589 mce related protein; Region: MCE; pfam02470 1160717007590 mce related protein; Region: MCE; pfam02470 1160717007591 mce related protein; Region: MCE; pfam02470 1160717007592 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1160717007593 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1160717007594 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1160717007595 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1160717007596 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1160717007597 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1160717007598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1160717007599 type III secretion protein SopE2; Provisional; Region: PRK15280 1160717007600 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1160717007601 SopE GEF domain; Region: SopE_GEF; pfam07487 1160717007602 putative phage 1160717007603 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1160717007604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1160717007605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1160717007606 MULE transposase domain; Region: MULE; pfam10551 1160717007607 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1160717007608 DNA binding site [nucleotide binding] 1160717007609 active site 1160717007610 Int/Topo IB signature motif; other site 1160717007611 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1160717007612 EamA-like transporter family; Region: EamA; pfam00892 1160717007613 EamA-like transporter family; Region: EamA; pfam00892 1160717007614 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1160717007615 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1160717007616 potential frameshift: common BLAST hit: gi|383496547|ref|YP_005397236.1| Phage Tail Assembly Protein 1160717007617 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1160717007618 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1160717007619 ADP-ribose binding site [chemical binding]; other site 1160717007620 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1160717007621 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1160717007622 exonuclease VIII; Reviewed; Region: PRK09709 1160717007623 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1160717007624 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1160717007625 hypothetical protein; Provisional; Region: PRK10301 1160717007626 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1160717007627 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1160717007628 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1160717007629 exodeoxyribonuclease X; Provisional; Region: PRK07983 1160717007630 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1160717007631 active site 1160717007632 catalytic site [active] 1160717007633 substrate binding site [chemical binding]; other site 1160717007634 protease 2; Provisional; Region: PRK10115 1160717007635 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1160717007636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1160717007637 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1160717007638 putative metal binding site [ion binding]; other site 1160717007639 hypothetical protein; Provisional; Region: PRK13680 1160717007640 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1160717007641 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1160717007642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1160717007643 ATP-grasp domain; Region: ATP-grasp; pfam02222 1160717007644 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1160717007645 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1160717007646 active site 1160717007647 intersubunit interface [polypeptide binding]; other site 1160717007648 catalytic residue [active] 1160717007649 phosphogluconate dehydratase; Validated; Region: PRK09054 1160717007650 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1160717007651 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1160717007652 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1160717007653 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1160717007654 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1160717007655 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1160717007656 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1160717007657 putative active site [active] 1160717007658 pyruvate kinase; Provisional; Region: PRK05826 1160717007659 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1160717007660 domain interfaces; other site 1160717007661 active site 1160717007662 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1160717007663 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1160717007664 putative acyl-acceptor binding pocket; other site 1160717007665 putative peptidase; Provisional; Region: PRK11649 1160717007666 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1160717007667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717007668 Peptidase family M23; Region: Peptidase_M23; pfam01551 1160717007669 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1160717007670 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1160717007671 metal binding site [ion binding]; metal-binding site 1160717007672 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1160717007673 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1160717007674 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1160717007675 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717007676 ABC-ATPase subunit interface; other site 1160717007677 dimer interface [polypeptide binding]; other site 1160717007678 putative PBP binding regions; other site 1160717007679 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1160717007680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717007681 Walker A motif; other site 1160717007682 ATP binding site [chemical binding]; other site 1160717007683 Walker B motif; other site 1160717007684 arginine finger; other site 1160717007685 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1160717007686 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1160717007687 RuvA N terminal domain; Region: RuvA_N; pfam01330 1160717007688 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1160717007689 hypothetical protein; Provisional; Region: PRK11470 1160717007690 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1160717007691 active site 1160717007692 putative DNA-binding cleft [nucleotide binding]; other site 1160717007693 dimer interface [polypeptide binding]; other site 1160717007694 hypothetical protein; Validated; Region: PRK00110 1160717007695 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1160717007696 nudix motif; other site 1160717007697 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1160717007698 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1160717007699 dimer interface [polypeptide binding]; other site 1160717007700 anticodon binding site; other site 1160717007701 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1160717007702 homodimer interface [polypeptide binding]; other site 1160717007703 motif 1; other site 1160717007704 active site 1160717007705 motif 2; other site 1160717007706 GAD domain; Region: GAD; pfam02938 1160717007707 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1160717007708 active site 1160717007709 motif 3; other site 1160717007710 Isochorismatase family; Region: Isochorismatase; pfam00857 1160717007711 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1160717007712 catalytic triad [active] 1160717007713 conserved cis-peptide bond; other site 1160717007714 hypothetical protein; Provisional; Region: PRK10302 1160717007715 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1160717007716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717007717 S-adenosylmethionine binding site [chemical binding]; other site 1160717007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717007719 S-adenosylmethionine binding site [chemical binding]; other site 1160717007720 copper homeostasis protein CutC; Provisional; Region: PRK11572 1160717007721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1160717007722 putative metal binding site [ion binding]; other site 1160717007723 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1160717007724 arginyl-tRNA synthetase; Region: argS; TIGR00456 1160717007725 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1160717007726 active site 1160717007727 HIGH motif; other site 1160717007728 KMSK motif region; other site 1160717007729 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1160717007730 tRNA binding surface [nucleotide binding]; other site 1160717007731 anticodon binding site; other site 1160717007732 penicillin-binding protein 2; Provisional; Region: PRK10795 1160717007733 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1160717007734 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1160717007735 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1160717007736 Flagellar protein FlhE; Region: FlhE; pfam06366 1160717007737 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1160717007738 FHIPEP family; Region: FHIPEP; pfam00771 1160717007739 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1160717007740 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1160717007741 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1160717007742 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1160717007743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717007744 active site 1160717007745 phosphorylation site [posttranslational modification] 1160717007746 intermolecular recognition site; other site 1160717007747 dimerization interface [polypeptide binding]; other site 1160717007748 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1160717007749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717007750 active site 1160717007751 phosphorylation site [posttranslational modification] 1160717007752 intermolecular recognition site; other site 1160717007753 dimerization interface [polypeptide binding]; other site 1160717007754 CheB methylesterase; Region: CheB_methylest; pfam01339 1160717007755 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1160717007756 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1160717007757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717007758 S-adenosylmethionine binding site [chemical binding]; other site 1160717007759 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1160717007760 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1160717007761 dimer interface [polypeptide binding]; other site 1160717007762 ligand binding site [chemical binding]; other site 1160717007763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717007764 dimerization interface [polypeptide binding]; other site 1160717007765 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717007766 dimer interface [polypeptide binding]; other site 1160717007767 putative CheW interface [polypeptide binding]; other site 1160717007768 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1160717007769 putative CheA interaction surface; other site 1160717007770 chemotaxis protein CheA; Provisional; Region: PRK10547 1160717007771 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1160717007772 putative binding surface; other site 1160717007773 active site 1160717007774 CheY binding; Region: CheY-binding; pfam09078 1160717007775 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1160717007776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717007777 ATP binding site [chemical binding]; other site 1160717007778 Mg2+ binding site [ion binding]; other site 1160717007779 G-X-G motif; other site 1160717007780 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1160717007781 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1160717007782 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1160717007783 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1160717007784 ligand binding site [chemical binding]; other site 1160717007785 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1160717007786 flagellar motor protein MotA; Validated; Region: PRK09110 1160717007787 transcriptional activator FlhC; Provisional; Region: PRK12722 1160717007788 transcriptional activator FlhD; Provisional; Region: PRK02909 1160717007789 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1160717007790 Ligand Binding Site [chemical binding]; other site 1160717007791 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1160717007792 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1160717007793 active site 1160717007794 homotetramer interface [polypeptide binding]; other site 1160717007795 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1160717007796 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1160717007797 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1160717007798 DJ-1 family protein; Region: not_thiJ; TIGR01383 1160717007799 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1160717007800 conserved cys residue [active] 1160717007801 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1160717007802 Ferritin-like domain; Region: Ferritin; pfam00210 1160717007803 ferroxidase diiron center [ion binding]; other site 1160717007804 hypothetical protein; Provisional; Region: PRK09273 1160717007805 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1160717007806 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1160717007807 YecR-like lipoprotein; Region: YecR; pfam13992 1160717007808 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1160717007809 Ferritin-like domain; Region: Ferritin; pfam00210 1160717007810 ferroxidase diiron center [ion binding]; other site 1160717007811 probable metal-binding protein; Region: matur_matur; TIGR03853 1160717007812 tyrosine transporter TyrP; Provisional; Region: PRK15132 1160717007813 aromatic amino acid transport protein; Region: araaP; TIGR00837 1160717007814 hypothetical protein; Provisional; Region: PRK10396 1160717007815 yecA family protein; Region: ygfB_yecA; TIGR02292 1160717007816 SEC-C motif; Region: SEC-C; pfam02810 1160717007817 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1160717007818 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1160717007819 NlpC/P60 family; Region: NLPC_P60; cl17555 1160717007820 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1160717007821 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1160717007822 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1160717007823 active site 1160717007824 catalytic site [active] 1160717007825 putative DNA binding site [nucleotide binding]; other site 1160717007826 GIY-YIG motif/motif A; other site 1160717007827 metal binding site [ion binding]; metal-binding site 1160717007828 UvrB/uvrC motif; Region: UVR; pfam02151 1160717007829 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1160717007830 Helix-hairpin-helix motif; Region: HHH; pfam00633 1160717007831 hypothetical protein; Provisional; Region: PRK10613 1160717007832 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1160717007833 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1160717007834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717007835 DNA binding residues [nucleotide binding] 1160717007836 dimerization interface [polypeptide binding]; other site 1160717007837 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1160717007838 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1160717007839 Walker A/P-loop; other site 1160717007840 ATP binding site [chemical binding]; other site 1160717007841 Q-loop/lid; other site 1160717007842 ABC transporter signature motif; other site 1160717007843 Walker B; other site 1160717007844 D-loop; other site 1160717007845 H-loop/switch region; other site 1160717007846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1160717007847 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717007848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717007849 dimer interface [polypeptide binding]; other site 1160717007850 conserved gate region; other site 1160717007851 putative PBP binding loops; other site 1160717007852 ABC-ATPase subunit interface; other site 1160717007853 D-cysteine desulfhydrase; Validated; Region: PRK03910 1160717007854 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1160717007855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717007856 catalytic residue [active] 1160717007857 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717007858 membrane-bound complex binding site; other site 1160717007859 hinge residues; other site 1160717007860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717007861 substrate binding pocket [chemical binding]; other site 1160717007862 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1160717007863 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1160717007864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1160717007865 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1160717007866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1160717007867 DNA binding residues [nucleotide binding] 1160717007868 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1160717007869 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1160717007870 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1160717007871 flagellar protein FliS; Validated; Region: fliS; PRK05685 1160717007872 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1160717007873 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1160717007874 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1160717007875 active site 1160717007876 Na/Ca binding site [ion binding]; other site 1160717007877 catalytic site [active] 1160717007878 lipoprotein; Provisional; Region: PRK10397 1160717007879 putative inner membrane protein; Provisional; Region: PRK11099 1160717007880 Sulphur transport; Region: Sulf_transp; pfam04143 1160717007881 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1160717007882 CPxP motif; other site 1160717007883 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1160717007884 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1160717007885 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1160717007886 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1160717007887 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1160717007888 FliG C-terminal domain; Region: FliG_C; pfam01706 1160717007889 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1160717007890 Flagellar assembly protein FliH; Region: FliH; pfam02108 1160717007891 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1160717007892 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1160717007893 Walker A motif/ATP binding site; other site 1160717007894 Walker B motif; other site 1160717007895 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1160717007896 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1160717007897 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1160717007898 flagellar hook-length control protein; Provisional; Region: PRK10118 1160717007899 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1160717007900 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1160717007901 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1160717007902 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1160717007903 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1160717007904 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1160717007905 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1160717007906 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1160717007907 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1160717007908 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1160717007909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717007910 DNA binding residues [nucleotide binding] 1160717007911 dimerization interface [polypeptide binding]; other site 1160717007912 hypothetical protein; Provisional; Region: PRK10708 1160717007913 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1160717007914 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1160717007915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717007916 active site 1160717007917 motif I; other site 1160717007918 motif II; other site 1160717007919 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1160717007920 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717007921 metal binding site [ion binding]; metal-binding site 1160717007922 active site 1160717007923 I-site; other site 1160717007924 Uncharacterized small protein [Function unknown]; Region: COG5475 1160717007925 hypothetical protein; Provisional; Region: PRK10062 1160717007926 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1160717007927 EamA-like transporter family; Region: EamA; pfam00892 1160717007928 EamA-like transporter family; Region: EamA; pfam00892 1160717007929 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1160717007930 additional DNA contacts [nucleotide binding]; other site 1160717007931 mismatch recognition site; other site 1160717007932 active site 1160717007933 zinc binding site [ion binding]; other site 1160717007934 DNA intercalation site [nucleotide binding]; other site 1160717007935 DNA cytosine methylase; Provisional; Region: PRK10458 1160717007936 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1160717007937 cofactor binding site; other site 1160717007938 DNA binding site [nucleotide binding] 1160717007939 substrate interaction site [chemical binding]; other site 1160717007940 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1160717007941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1160717007942 Zn2+ binding site [ion binding]; other site 1160717007943 Mg2+ binding site [ion binding]; other site 1160717007944 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717007945 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717007946 trimer interface [polypeptide binding]; other site 1160717007947 eyelet of channel; other site 1160717007948 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1160717007949 DNA-binding site [nucleotide binding]; DNA binding site 1160717007950 RNA-binding motif; other site 1160717007951 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1160717007952 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1160717007953 active site 1160717007954 DNA binding site [nucleotide binding] 1160717007955 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1160717007956 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1160717007957 Catalytic site [active] 1160717007958 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1160717007959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1160717007960 putative protease; Region: PHA00666 1160717007961 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1160717007962 Integrase; Region: Integrase_1; pfam12835 1160717007963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1160717007964 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717007965 Sel1 repeat; Region: Sel1; pfam08238 1160717007966 Sel1-like repeats; Region: SEL1; smart00671 1160717007967 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1160717007968 AMP nucleosidase; Provisional; Region: PRK08292 1160717007969 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1160717007970 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1160717007971 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1160717007972 MATE family multidrug exporter; Provisional; Region: PRK10189 1160717007973 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1160717007974 L,D-transpeptidase; Provisional; Region: PRK10190 1160717007975 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1160717007976 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1160717007977 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1160717007978 putative dimer interface [polypeptide binding]; other site 1160717007979 active site pocket [active] 1160717007980 putative cataytic base [active] 1160717007981 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1160717007982 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1160717007983 homotrimer interface [polypeptide binding]; other site 1160717007984 Walker A motif; other site 1160717007985 GTP binding site [chemical binding]; other site 1160717007986 Walker B motif; other site 1160717007987 cobyric acid synthase; Provisional; Region: PRK00784 1160717007988 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1160717007989 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1160717007990 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1160717007991 catalytic triad [active] 1160717007992 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1160717007993 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1160717007994 Walker A/P-loop; other site 1160717007995 ATP binding site [chemical binding]; other site 1160717007996 Q-loop/lid; other site 1160717007997 ABC transporter signature motif; other site 1160717007998 Walker B; other site 1160717007999 D-loop; other site 1160717008000 H-loop/switch region; other site 1160717008001 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1160717008002 cobalt transport protein CbiN; Provisional; Region: PRK02898 1160717008003 cobalt transport protein CbiM; Validated; Region: PRK08319 1160717008004 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1160717008005 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1160717008006 active site 1160717008007 SAM binding site [chemical binding]; other site 1160717008008 homodimer interface [polypeptide binding]; other site 1160717008009 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1160717008010 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1160717008011 active site 1160717008012 C-terminal domain interface [polypeptide binding]; other site 1160717008013 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1160717008014 active site 1160717008015 N-terminal domain interface [polypeptide binding]; other site 1160717008016 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1160717008017 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1160717008018 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1160717008019 active site 1160717008020 SAM binding site [chemical binding]; other site 1160717008021 homodimer interface [polypeptide binding]; other site 1160717008022 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1160717008023 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1160717008024 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1160717008025 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1160717008026 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1160717008027 active site 1160717008028 SAM binding site [chemical binding]; other site 1160717008029 homodimer interface [polypeptide binding]; other site 1160717008030 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1160717008031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717008032 S-adenosylmethionine binding site [chemical binding]; other site 1160717008033 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1160717008034 active site 1160717008035 putative homodimer interface [polypeptide binding]; other site 1160717008036 SAM binding site [chemical binding]; other site 1160717008037 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1160717008038 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1160717008039 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1160717008040 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1160717008041 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1160717008042 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1160717008043 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1160717008044 catalytic triad [active] 1160717008045 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1160717008046 Sensory domain found in PocR; Region: PocR; pfam10114 1160717008047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717008048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717008049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717008050 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1160717008051 amphipathic channel; other site 1160717008052 Asn-Pro-Ala signature motifs; other site 1160717008053 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1160717008054 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1160717008055 Hexamer interface [polypeptide binding]; other site 1160717008056 Putative hexagonal pore residue; other site 1160717008057 propanediol utilization protein PduB; Provisional; Region: PRK15415 1160717008058 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1160717008059 putative hexamer interface [polypeptide binding]; other site 1160717008060 putative hexagonal pore; other site 1160717008061 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1160717008062 putative hexamer interface [polypeptide binding]; other site 1160717008063 putative hexagonal pore; other site 1160717008064 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1160717008065 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1160717008066 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1160717008067 alpha-beta subunit interface [polypeptide binding]; other site 1160717008068 alpha-gamma subunit interface [polypeptide binding]; other site 1160717008069 active site 1160717008070 substrate and K+ binding site; other site 1160717008071 K+ binding site [ion binding]; other site 1160717008072 cobalamin binding site [chemical binding]; other site 1160717008073 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1160717008074 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1160717008075 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1160717008076 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1160717008077 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1160717008078 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1160717008079 Hexamer interface [polypeptide binding]; other site 1160717008080 Putative hexagonal pore residue; other site 1160717008081 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1160717008082 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1160717008083 putative hexamer interface [polypeptide binding]; other site 1160717008084 putative hexagonal pore; other site 1160717008085 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1160717008086 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1160717008087 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1160717008088 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1160717008089 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1160717008090 Hexamer/Pentamer interface [polypeptide binding]; other site 1160717008091 central pore; other site 1160717008092 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1160717008093 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1160717008094 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1160717008095 putative catalytic cysteine [active] 1160717008096 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1160717008097 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1160717008098 putative active site [active] 1160717008099 metal binding site [ion binding]; metal-binding site 1160717008100 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1160717008101 SLBB domain; Region: SLBB; pfam10531 1160717008102 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1160717008103 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1160717008104 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1160717008105 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1160717008106 putative hexamer interface [polypeptide binding]; other site 1160717008107 putative hexagonal pore; other site 1160717008108 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1160717008109 putative hexamer interface [polypeptide binding]; other site 1160717008110 putative hexagonal pore; other site 1160717008111 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1160717008112 putative hexamer interface [polypeptide binding]; other site 1160717008113 putative hexagonal pore; other site 1160717008114 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 1160717008115 G3 box; other site 1160717008116 Switch II region; other site 1160717008117 GTP/Mg2+ binding site [chemical binding]; other site 1160717008118 G4 box; other site 1160717008119 G5 box; other site 1160717008120 propionate kinase; Reviewed; Region: PRK12397 1160717008121 propionate/acetate kinase; Provisional; Region: PRK12379 1160717008122 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1160717008123 hypothetical protein; Provisional; Region: PRK05423 1160717008124 Predicted membrane protein [Function unknown]; Region: COG1289 1160717008125 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1160717008126 DNA gyrase inhibitor; Provisional; Region: PRK10016 1160717008127 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1160717008128 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1160717008129 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1160717008130 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1160717008131 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1160717008132 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1160717008133 4Fe-4S binding domain; Region: Fer4; cl02805 1160717008134 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1160717008135 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1160717008136 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1160717008137 putative [Fe4-S4] binding site [ion binding]; other site 1160717008138 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717008139 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1160717008140 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1160717008141 putative molybdopterin cofactor binding site; other site 1160717008142 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 1160717008143 SopA-like central domain; Region: SopA; pfam13981 1160717008144 SopA-like catalytic domain; Region: SopA_C; pfam13979 1160717008145 exonuclease I; Provisional; Region: sbcB; PRK11779 1160717008146 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1160717008147 active site 1160717008148 catalytic site [active] 1160717008149 substrate binding site [chemical binding]; other site 1160717008150 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1160717008151 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1160717008152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717008153 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1160717008154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717008155 dimerization interface [polypeptide binding]; other site 1160717008156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1160717008157 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1160717008158 putative NAD(P) binding site [chemical binding]; other site 1160717008159 His_leader; SU5_nc93 1160717008160 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1160717008161 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1160717008162 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1160717008163 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1160717008164 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1160717008165 NAD binding site [chemical binding]; other site 1160717008166 dimerization interface [polypeptide binding]; other site 1160717008167 product binding site; other site 1160717008168 substrate binding site [chemical binding]; other site 1160717008169 zinc binding site [ion binding]; other site 1160717008170 catalytic residues [active] 1160717008171 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1160717008172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717008173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717008174 homodimer interface [polypeptide binding]; other site 1160717008175 catalytic residue [active] 1160717008176 genomic island 1160717008177 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1160717008178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717008179 active site 1160717008180 motif I; other site 1160717008181 motif II; other site 1160717008182 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1160717008183 putative active site pocket [active] 1160717008184 4-fold oligomerization interface [polypeptide binding]; other site 1160717008185 metal binding residues [ion binding]; metal-binding site 1160717008186 3-fold/trimer interface [polypeptide binding]; other site 1160717008187 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1160717008188 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1160717008189 putative active site [active] 1160717008190 oxyanion strand; other site 1160717008191 catalytic triad [active] 1160717008192 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1160717008193 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1160717008194 catalytic residues [active] 1160717008195 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1160717008196 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1160717008197 substrate binding site [chemical binding]; other site 1160717008198 glutamase interaction surface [polypeptide binding]; other site 1160717008199 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1160717008200 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1160717008201 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1160717008202 metal binding site [ion binding]; metal-binding site 1160717008203 chain length determinant protein WzzB; Provisional; Region: PRK15471 1160717008204 Chain length determinant protein; Region: Wzz; pfam02706 1160717008205 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1160717008206 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1160717008207 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1160717008208 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1160717008209 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1160717008210 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1160717008211 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1160717008212 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1160717008213 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1160717008214 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1160717008215 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1160717008216 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1160717008217 active site 1160717008218 substrate binding site [chemical binding]; other site 1160717008219 metal binding site [ion binding]; metal-binding site 1160717008220 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1160717008221 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1160717008222 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1160717008223 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1160717008224 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1160717008225 active site 1160717008226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717008227 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1160717008228 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1160717008229 active site 1160717008230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1160717008231 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1160717008232 NAD(P) binding site [chemical binding]; other site 1160717008233 active site 1160717008234 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1160717008235 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1160717008236 inhibitor-cofactor binding pocket; inhibition site 1160717008237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717008238 catalytic residue [active] 1160717008239 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1160717008240 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1160717008241 NAD binding site [chemical binding]; other site 1160717008242 homotetramer interface [polypeptide binding]; other site 1160717008243 homodimer interface [polypeptide binding]; other site 1160717008244 substrate binding site [chemical binding]; other site 1160717008245 active site 1160717008246 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1160717008247 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1160717008248 substrate binding site; other site 1160717008249 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1160717008250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1160717008251 catalytic loop [active] 1160717008252 iron binding site [ion binding]; other site 1160717008253 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1160717008254 FAD binding pocket [chemical binding]; other site 1160717008255 FAD binding motif [chemical binding]; other site 1160717008256 phosphate binding motif [ion binding]; other site 1160717008257 beta-alpha-beta structure motif; other site 1160717008258 NAD binding pocket [chemical binding]; other site 1160717008259 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1160717008260 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1160717008261 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1160717008262 substrate binding site; other site 1160717008263 tetramer interface; other site 1160717008264 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1160717008265 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1160717008266 NADP binding site [chemical binding]; other site 1160717008267 active site 1160717008268 putative substrate binding site [chemical binding]; other site 1160717008269 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1160717008270 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1160717008271 NAD binding site [chemical binding]; other site 1160717008272 substrate binding site [chemical binding]; other site 1160717008273 homodimer interface [polypeptide binding]; other site 1160717008274 active site 1160717008275 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1160717008276 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1160717008277 active site 1160717008278 tetramer interface; other site 1160717008279 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1160717008280 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1160717008281 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1160717008282 putative ADP-binding pocket [chemical binding]; other site 1160717008283 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1160717008284 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1160717008285 colanic acid exporter; Provisional; Region: PRK10459 1160717008286 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1160717008287 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1160717008288 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1160717008289 phosphomannomutase CpsG; Provisional; Region: PRK15414 1160717008290 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1160717008291 active site 1160717008292 substrate binding site [chemical binding]; other site 1160717008293 metal binding site [ion binding]; metal-binding site 1160717008294 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1160717008295 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1160717008296 Substrate binding site; other site 1160717008297 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1160717008298 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1160717008299 active site 1160717008300 GDP-Mannose binding site [chemical binding]; other site 1160717008301 dimer interface [polypeptide binding]; other site 1160717008302 modified nudix motif 1160717008303 metal binding site [ion binding]; metal-binding site 1160717008304 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1160717008305 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1160717008306 NADP binding site [chemical binding]; other site 1160717008307 active site 1160717008308 putative substrate binding site [chemical binding]; other site 1160717008309 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1160717008310 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1160717008311 NADP-binding site; other site 1160717008312 homotetramer interface [polypeptide binding]; other site 1160717008313 substrate binding site [chemical binding]; other site 1160717008314 homodimer interface [polypeptide binding]; other site 1160717008315 active site 1160717008316 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1160717008317 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1160717008318 putative trimer interface [polypeptide binding]; other site 1160717008319 putative active site [active] 1160717008320 putative substrate binding site [chemical binding]; other site 1160717008321 putative CoA binding site [chemical binding]; other site 1160717008322 putative glycosyl transferase; Provisional; Region: PRK10063 1160717008323 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1160717008324 metal-binding site 1160717008325 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1160717008326 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1160717008327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1160717008328 putative acyl transferase; Provisional; Region: PRK10191 1160717008329 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1160717008330 trimer interface [polypeptide binding]; other site 1160717008331 active site 1160717008332 substrate binding site [chemical binding]; other site 1160717008333 CoA binding site [chemical binding]; other site 1160717008334 putative glycosyl transferase; Provisional; Region: PRK10018 1160717008335 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1160717008336 active site 1160717008337 tyrosine kinase; Provisional; Region: PRK11519 1160717008338 Chain length determinant protein; Region: Wzz; pfam02706 1160717008339 Chain length determinant protein; Region: Wzz; cl15801 1160717008340 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1160717008341 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1160717008342 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1160717008343 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1160717008344 active site 1160717008345 polysaccharide export protein Wza; Provisional; Region: PRK15078 1160717008346 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1160717008347 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1160717008348 FOG: CBS domain [General function prediction only]; Region: COG0517 1160717008349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1160717008350 Transporter associated domain; Region: CorC_HlyC; smart01091 1160717008351 putative assembly protein; Provisional; Region: PRK10833 1160717008352 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1160717008353 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1160717008354 trimer interface [polypeptide binding]; other site 1160717008355 active site 1160717008356 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1160717008357 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1160717008358 ATP-binding site [chemical binding]; other site 1160717008359 Sugar specificity; other site 1160717008360 Pyrimidine base specificity; other site 1160717008361 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1160717008362 PAS domain S-box; Region: sensory_box; TIGR00229 1160717008363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717008364 putative active site [active] 1160717008365 heme pocket [chemical binding]; other site 1160717008366 PAS domain S-box; Region: sensory_box; TIGR00229 1160717008367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717008368 putative active site [active] 1160717008369 heme pocket [chemical binding]; other site 1160717008370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1160717008371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717008372 metal binding site [ion binding]; metal-binding site 1160717008373 active site 1160717008374 I-site; other site 1160717008375 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717008376 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1160717008377 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1160717008378 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1160717008379 minor groove reading motif; other site 1160717008380 helix-hairpin-helix signature motif; other site 1160717008381 substrate binding pocket [chemical binding]; other site 1160717008382 active site 1160717008383 putative chaperone; Provisional; Region: PRK11678 1160717008384 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1160717008385 nucleotide binding site [chemical binding]; other site 1160717008386 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1160717008387 SBD interface [polypeptide binding]; other site 1160717008388 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1160717008389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717008390 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717008391 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1160717008392 putative transporter; Provisional; Region: PRK10504 1160717008393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008394 putative substrate translocation pore; other site 1160717008395 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1160717008396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717008397 dimerization interface [polypeptide binding]; other site 1160717008398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717008399 dimer interface [polypeptide binding]; other site 1160717008400 phosphorylation site [posttranslational modification] 1160717008401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717008402 ATP binding site [chemical binding]; other site 1160717008403 Mg2+ binding site [ion binding]; other site 1160717008404 G-X-G motif; other site 1160717008405 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1160717008406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717008407 active site 1160717008408 phosphorylation site [posttranslational modification] 1160717008409 intermolecular recognition site; other site 1160717008410 dimerization interface [polypeptide binding]; other site 1160717008411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717008412 DNA binding site [nucleotide binding] 1160717008413 PcfJ-like protein; Region: PcfJ; pfam14284 1160717008414 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1160717008415 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 1160717008416 putative protease; Provisional; Region: PRK15452 1160717008417 Peptidase family U32; Region: Peptidase_U32; pfam01136 1160717008418 type III secretion system protein; Provisional; Region: PRK15383 1160717008419 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1160717008420 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1160717008421 lipid kinase; Reviewed; Region: PRK13054 1160717008422 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1160717008423 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1160717008424 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1160717008425 putative active site; other site 1160717008426 catalytic residue [active] 1160717008427 nucleoside transporter; Region: 2A0110; TIGR00889 1160717008428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008429 putative substrate translocation pore; other site 1160717008430 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1160717008431 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717008432 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1160717008433 substrate binding site [chemical binding]; other site 1160717008434 ATP binding site [chemical binding]; other site 1160717008435 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1160717008436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717008437 DNA-binding site [nucleotide binding]; DNA binding site 1160717008438 UTRA domain; Region: UTRA; pfam07702 1160717008439 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1160717008440 dimer interface [polypeptide binding]; other site 1160717008441 substrate binding site [chemical binding]; other site 1160717008442 ATP binding site [chemical binding]; other site 1160717008443 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1160717008444 substrate binding site [chemical binding]; other site 1160717008445 multimerization interface [polypeptide binding]; other site 1160717008446 ATP binding site [chemical binding]; other site 1160717008447 Predicted integral membrane protein [Function unknown]; Region: COG5455 1160717008448 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1160717008449 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1160717008450 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1160717008451 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717008452 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717008453 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717008454 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 1160717008455 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717008456 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717008457 fimbrial chaperone protein; Provisional; Region: PRK15220 1160717008458 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1160717008459 antiporter inner membrane protein; Provisional; Region: PRK11670 1160717008460 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1160717008461 Walker A motif; other site 1160717008462 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1160717008463 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1160717008464 active site 1160717008465 HIGH motif; other site 1160717008466 KMSKS motif; other site 1160717008467 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1160717008468 tRNA binding surface [nucleotide binding]; other site 1160717008469 anticodon binding site; other site 1160717008470 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1160717008471 dimer interface [polypeptide binding]; other site 1160717008472 putative tRNA-binding site [nucleotide binding]; other site 1160717008473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1160717008474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1160717008475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1160717008476 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1160717008477 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1160717008478 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1160717008479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717008480 active site 1160717008481 phosphorylation site [posttranslational modification] 1160717008482 intermolecular recognition site; other site 1160717008483 dimerization interface [polypeptide binding]; other site 1160717008484 LytTr DNA-binding domain; Region: LytTR; pfam04397 1160717008485 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1160717008486 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1160717008487 GAF domain; Region: GAF; pfam01590 1160717008488 Histidine kinase; Region: His_kinase; pfam06580 1160717008489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717008490 ATP binding site [chemical binding]; other site 1160717008491 Mg2+ binding site [ion binding]; other site 1160717008492 G-X-G motif; other site 1160717008493 transcriptional regulator MirA; Provisional; Region: PRK15043 1160717008494 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1160717008495 DNA binding residues [nucleotide binding] 1160717008496 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1160717008497 putative PBP binding loops; other site 1160717008498 ABC-ATPase subunit interface; other site 1160717008499 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1160717008500 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1160717008501 Walker A/P-loop; other site 1160717008502 ATP binding site [chemical binding]; other site 1160717008503 Q-loop/lid; other site 1160717008504 ABC transporter signature motif; other site 1160717008505 Walker B; other site 1160717008506 D-loop; other site 1160717008507 H-loop/switch region; other site 1160717008508 CBS domain; Region: CBS; pfam00571 1160717008509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717008510 dimer interface [polypeptide binding]; other site 1160717008511 conserved gate region; other site 1160717008512 ABC-ATPase subunit interface; other site 1160717008513 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1160717008514 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1160717008515 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1160717008516 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1160717008517 D-lactate dehydrogenase; Provisional; Region: PRK11183 1160717008518 FAD binding domain; Region: FAD_binding_4; pfam01565 1160717008519 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1160717008520 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1160717008521 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1160717008522 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1160717008523 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1160717008524 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1160717008525 oxidoreductase; Provisional; Region: PRK12743 1160717008526 classical (c) SDRs; Region: SDR_c; cd05233 1160717008527 NAD(P) binding site [chemical binding]; other site 1160717008528 active site 1160717008529 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1160717008530 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1160717008531 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1160717008532 FMN binding site [chemical binding]; other site 1160717008533 active site 1160717008534 catalytic residues [active] 1160717008535 substrate binding site [chemical binding]; other site 1160717008536 salicylate hydroxylase; Provisional; Region: PRK08163 1160717008537 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1160717008538 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1160717008539 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1160717008540 C-terminal domain interface [polypeptide binding]; other site 1160717008541 GSH binding site (G-site) [chemical binding]; other site 1160717008542 putative dimer interface [polypeptide binding]; other site 1160717008543 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1160717008544 dimer interface [polypeptide binding]; other site 1160717008545 N-terminal domain interface [polypeptide binding]; other site 1160717008546 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1160717008547 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1160717008548 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1160717008549 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1160717008550 Cupin domain; Region: Cupin_2; pfam07883 1160717008551 Cupin domain; Region: Cupin_2; pfam07883 1160717008552 benzoate transport; Region: 2A0115; TIGR00895 1160717008553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008554 putative substrate translocation pore; other site 1160717008555 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1160717008556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717008557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717008558 dimerization interface [polypeptide binding]; other site 1160717008559 hypothetical protein; Provisional; Region: PRK01821 1160717008560 hypothetical protein; Provisional; Region: PRK10711 1160717008561 cytidine deaminase; Provisional; Region: PRK09027 1160717008562 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1160717008563 active site 1160717008564 catalytic motif [active] 1160717008565 Zn binding site [ion binding]; other site 1160717008566 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1160717008567 active site 1160717008568 catalytic motif [active] 1160717008569 Zn binding site [ion binding]; other site 1160717008570 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1160717008571 putative active site [active] 1160717008572 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1160717008573 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1160717008574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1160717008575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717008576 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1160717008577 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1160717008578 homodimer interface [polypeptide binding]; other site 1160717008579 active site 1160717008580 FMN binding site [chemical binding]; other site 1160717008581 substrate binding site [chemical binding]; other site 1160717008582 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1160717008583 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1160717008584 TM-ABC transporter signature motif; other site 1160717008585 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1160717008586 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1160717008587 Walker A/P-loop; other site 1160717008588 ATP binding site [chemical binding]; other site 1160717008589 Q-loop/lid; other site 1160717008590 ABC transporter signature motif; other site 1160717008591 Walker B; other site 1160717008592 D-loop; other site 1160717008593 H-loop/switch region; other site 1160717008594 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1160717008595 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1160717008596 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1160717008597 ligand binding site [chemical binding]; other site 1160717008598 calcium binding site [ion binding]; other site 1160717008599 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1160717008600 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717008601 DNA binding site [nucleotide binding] 1160717008602 domain linker motif; other site 1160717008603 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1160717008604 dimerization interface (closed form) [polypeptide binding]; other site 1160717008605 ligand binding site [chemical binding]; other site 1160717008606 Predicted membrane protein [Function unknown]; Region: COG2311 1160717008607 hypothetical protein; Provisional; Region: PRK10835 1160717008608 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1160717008609 GTP cyclohydrolase I; Provisional; Region: PLN03044 1160717008610 active site 1160717008611 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1160717008612 S-formylglutathione hydrolase; Region: PLN02442 1160717008613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717008614 non-specific DNA binding site [nucleotide binding]; other site 1160717008615 salt bridge; other site 1160717008616 sequence-specific DNA binding site [nucleotide binding]; other site 1160717008617 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1160717008618 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1160717008619 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1160717008620 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1160717008621 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1160717008622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717008623 motif II; other site 1160717008624 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1160717008625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008626 putative substrate translocation pore; other site 1160717008627 lysine transporter; Provisional; Region: PRK10836 1160717008628 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1160717008629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717008630 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1160717008631 putative dimerization interface [polypeptide binding]; other site 1160717008632 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1160717008633 endonuclease IV; Provisional; Region: PRK01060 1160717008634 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1160717008635 AP (apurinic/apyrimidinic) site pocket; other site 1160717008636 DNA interaction; other site 1160717008637 Metal-binding active site; metal-binding site 1160717008638 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1160717008639 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1160717008640 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1160717008641 active site 1160717008642 P-loop; other site 1160717008643 phosphorylation site [posttranslational modification] 1160717008644 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1160717008645 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1160717008646 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1160717008647 putative substrate binding site [chemical binding]; other site 1160717008648 putative ATP binding site [chemical binding]; other site 1160717008649 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1160717008650 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717008651 active site 1160717008652 phosphorylation site [posttranslational modification] 1160717008653 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1160717008654 dimerization domain swap beta strand [polypeptide binding]; other site 1160717008655 regulatory protein interface [polypeptide binding]; other site 1160717008656 active site 1160717008657 regulatory phosphorylation site [posttranslational modification]; other site 1160717008658 sugar efflux transporter B; Provisional; Region: PRK15011 1160717008659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008660 putative substrate translocation pore; other site 1160717008661 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1160717008662 Flagellin N-methylase; Region: FliB; cl00497 1160717008663 elongation factor P; Provisional; Region: PRK04542 1160717008664 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1160717008665 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1160717008666 RNA binding site [nucleotide binding]; other site 1160717008667 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1160717008668 RNA binding site [nucleotide binding]; other site 1160717008669 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1160717008670 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1160717008671 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1160717008672 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1160717008673 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1160717008674 active site 1160717008675 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1160717008676 NlpC/P60 family; Region: NLPC_P60; pfam00877 1160717008677 phage resistance protein; Provisional; Region: PRK10551 1160717008678 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1160717008679 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717008680 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1160717008681 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1160717008682 microcin C ABC transporter permease; Provisional; Region: PRK15021 1160717008683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717008684 dimer interface [polypeptide binding]; other site 1160717008685 conserved gate region; other site 1160717008686 ABC-ATPase subunit interface; other site 1160717008687 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1160717008688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717008689 Walker A/P-loop; other site 1160717008690 ATP binding site [chemical binding]; other site 1160717008691 Q-loop/lid; other site 1160717008692 ABC transporter signature motif; other site 1160717008693 Walker B; other site 1160717008694 D-loop; other site 1160717008695 H-loop/switch region; other site 1160717008696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1160717008697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717008698 Walker A/P-loop; other site 1160717008699 ATP binding site [chemical binding]; other site 1160717008700 Q-loop/lid; other site 1160717008701 ABC transporter signature motif; other site 1160717008702 Walker B; other site 1160717008703 D-loop; other site 1160717008704 H-loop/switch region; other site 1160717008705 hypothetical protein; Provisional; Region: PRK11835 1160717008706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008707 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1160717008708 putative substrate translocation pore; other site 1160717008709 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1160717008710 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717008711 RNA binding surface [nucleotide binding]; other site 1160717008712 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1160717008713 active site 1160717008714 uracil binding [chemical binding]; other site 1160717008715 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1160717008716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717008717 ATP binding site [chemical binding]; other site 1160717008718 putative Mg++ binding site [ion binding]; other site 1160717008719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717008720 nucleotide binding region [chemical binding]; other site 1160717008721 ATP-binding site [chemical binding]; other site 1160717008722 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1160717008723 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1160717008724 5S rRNA interface [nucleotide binding]; other site 1160717008725 CTC domain interface [polypeptide binding]; other site 1160717008726 L16 interface [polypeptide binding]; other site 1160717008727 genomic island 1160717008728 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1160717008729 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1160717008730 putative phage 1160717008731 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1160717008732 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1160717008733 Sulfatase; Region: Sulfatase; cl17466 1160717008734 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1160717008735 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1160717008736 Catalytic site [active] 1160717008737 DinI-like family; Region: DinI; cl11630 1160717008738 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1160717008739 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1160717008740 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1160717008741 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 1160717008742 Phage head maturation protease [General function prediction only]; Region: COG3740 1160717008743 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1160717008744 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1160717008745 potential frameshift: common BLAST hit: gi|383496942|ref|YP_005397631.1| putative bacteriophage protein 1160717008746 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1160717008747 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1160717008748 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1160717008749 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1160717008750 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1160717008751 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 1160717008752 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1160717008753 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1160717008754 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1160717008755 Leucine-rich repeats; other site 1160717008756 Substrate binding site [chemical binding]; other site 1160717008757 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1160717008758 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1160717008759 transcriptional regulator NarP; Provisional; Region: PRK10403 1160717008760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717008761 active site 1160717008762 phosphorylation site [posttranslational modification] 1160717008763 intermolecular recognition site; other site 1160717008764 dimerization interface [polypeptide binding]; other site 1160717008765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717008766 DNA binding residues [nucleotide binding] 1160717008767 dimerization interface [polypeptide binding]; other site 1160717008768 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1160717008769 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1160717008770 catalytic residues [active] 1160717008771 central insert; other site 1160717008772 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1160717008773 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1160717008774 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1160717008775 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1160717008776 heme exporter protein CcmC; Region: ccmC; TIGR01191 1160717008777 heme exporter protein CcmB; Region: ccmB; TIGR01190 1160717008778 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1160717008779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717008780 Walker A/P-loop; other site 1160717008781 ATP binding site [chemical binding]; other site 1160717008782 Q-loop/lid; other site 1160717008783 ABC transporter signature motif; other site 1160717008784 Walker B; other site 1160717008785 D-loop; other site 1160717008786 H-loop/switch region; other site 1160717008787 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1160717008788 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1160717008789 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1160717008790 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1160717008791 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1160717008792 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717008793 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1160717008794 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1160717008795 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1160717008796 [4Fe-4S] binding site [ion binding]; other site 1160717008797 molybdopterin cofactor binding site; other site 1160717008798 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1160717008799 molybdopterin cofactor binding site; other site 1160717008800 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1160717008801 ferredoxin-type protein; Provisional; Region: PRK10194 1160717008802 4Fe-4S binding domain; Region: Fer4; cl02805 1160717008803 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1160717008804 secondary substrate binding site; other site 1160717008805 primary substrate binding site; other site 1160717008806 inhibition loop; other site 1160717008807 dimerization interface [polypeptide binding]; other site 1160717008808 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1160717008809 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1160717008810 Walker A/P-loop; other site 1160717008811 ATP binding site [chemical binding]; other site 1160717008812 Q-loop/lid; other site 1160717008813 ABC transporter signature motif; other site 1160717008814 Walker B; other site 1160717008815 D-loop; other site 1160717008816 H-loop/switch region; other site 1160717008817 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1160717008818 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1160717008819 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1160717008820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717008821 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1160717008822 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1160717008823 DNA binding site [nucleotide binding] 1160717008824 active site 1160717008825 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1160717008826 ApbE family; Region: ApbE; pfam02424 1160717008827 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1160717008828 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1160717008829 trimer interface [polypeptide binding]; other site 1160717008830 eyelet of channel; other site 1160717008831 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1160717008832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717008833 ATP binding site [chemical binding]; other site 1160717008834 G-X-G motif; other site 1160717008835 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1160717008836 putative binding surface; other site 1160717008837 active site 1160717008838 transcriptional regulator RcsB; Provisional; Region: PRK10840 1160717008839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717008840 active site 1160717008841 phosphorylation site [posttranslational modification] 1160717008842 intermolecular recognition site; other site 1160717008843 dimerization interface [polypeptide binding]; other site 1160717008844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717008845 DNA binding residues [nucleotide binding] 1160717008846 dimerization interface [polypeptide binding]; other site 1160717008847 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1160717008848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717008849 dimer interface [polypeptide binding]; other site 1160717008850 phosphorylation site [posttranslational modification] 1160717008851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717008852 ATP binding site [chemical binding]; other site 1160717008853 Mg2+ binding site [ion binding]; other site 1160717008854 G-X-G motif; other site 1160717008855 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1160717008856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717008857 active site 1160717008858 phosphorylation site [posttranslational modification] 1160717008859 intermolecular recognition site; other site 1160717008860 dimerization interface [polypeptide binding]; other site 1160717008861 DNA gyrase subunit A; Validated; Region: PRK05560 1160717008862 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1160717008863 CAP-like domain; other site 1160717008864 active site 1160717008865 primary dimer interface [polypeptide binding]; other site 1160717008866 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717008867 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717008868 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717008869 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717008870 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717008871 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717008872 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1160717008873 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1160717008874 active site pocket [active] 1160717008875 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1160717008876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008877 putative substrate translocation pore; other site 1160717008878 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1160717008879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717008880 DNA-binding site [nucleotide binding]; DNA binding site 1160717008881 FCD domain; Region: FCD; pfam07729 1160717008882 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1160717008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717008884 S-adenosylmethionine binding site [chemical binding]; other site 1160717008885 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1160717008886 ATP cone domain; Region: ATP-cone; pfam03477 1160717008887 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1160717008888 active site 1160717008889 dimer interface [polypeptide binding]; other site 1160717008890 catalytic residues [active] 1160717008891 effector binding site; other site 1160717008892 R2 peptide binding site; other site 1160717008893 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1160717008894 dimer interface [polypeptide binding]; other site 1160717008895 putative radical transfer pathway; other site 1160717008896 diiron center [ion binding]; other site 1160717008897 tyrosyl radical; other site 1160717008898 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1160717008899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1160717008900 catalytic loop [active] 1160717008901 iron binding site [ion binding]; other site 1160717008902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717008903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008904 putative substrate translocation pore; other site 1160717008905 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1160717008906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717008907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717008908 dimerization interface [polypeptide binding]; other site 1160717008909 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1160717008910 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1160717008911 active site 1160717008912 catalytic site [active] 1160717008913 metal binding site [ion binding]; metal-binding site 1160717008914 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1160717008915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008916 putative substrate translocation pore; other site 1160717008917 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1160717008918 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1160717008919 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1160717008920 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1160717008921 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1160717008922 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1160717008923 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717008924 Cysteine-rich domain; Region: CCG; pfam02754 1160717008925 Cysteine-rich domain; Region: CCG; pfam02754 1160717008926 deubiquitinase SseL; Provisional; Region: PRK14848 1160717008927 hypothetical protein; Provisional; Region: PRK03673 1160717008928 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1160717008929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717008930 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717008931 putative substrate translocation pore; other site 1160717008932 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1160717008933 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1160717008934 putative active site pocket [active] 1160717008935 putative metal binding site [ion binding]; other site 1160717008936 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1160717008937 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1160717008938 Bacterial transcriptional regulator; Region: IclR; pfam01614 1160717008939 hypothetical protein; Provisional; Region: PRK03673 1160717008940 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1160717008941 putative MPT binding site; other site 1160717008942 Competence-damaged protein; Region: CinA; cl00666 1160717008943 YfaZ precursor; Region: YfaZ; pfam07437 1160717008944 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1160717008945 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1160717008946 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1160717008947 catalytic core [active] 1160717008948 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1160717008949 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1160717008950 inhibitor-cofactor binding pocket; inhibition site 1160717008951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717008952 catalytic residue [active] 1160717008953 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1160717008954 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1160717008955 Ligand binding site; other site 1160717008956 Putative Catalytic site; other site 1160717008957 DXD motif; other site 1160717008958 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1160717008959 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1160717008960 active site 1160717008961 substrate binding site [chemical binding]; other site 1160717008962 cosubstrate binding site; other site 1160717008963 catalytic site [active] 1160717008964 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1160717008965 active site 1160717008966 hexamer interface [polypeptide binding]; other site 1160717008967 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1160717008968 NAD binding site [chemical binding]; other site 1160717008969 substrate binding site [chemical binding]; other site 1160717008970 active site 1160717008971 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1160717008972 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1160717008973 Polymyxin resistance protein ArnT, undecaprenyl phosphate-alpha-L-Ara4N transferase; Melittin resistance protein PqaB 1160717008974 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1160717008975 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1160717008976 signal transduction protein PmrD; Provisional; Region: PRK15450 1160717008977 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1160717008978 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1160717008979 acyl-activating enzyme (AAE) consensus motif; other site 1160717008980 putative AMP binding site [chemical binding]; other site 1160717008981 putative active site [active] 1160717008982 putative CoA binding site [chemical binding]; other site 1160717008983 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 1160717008984 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1160717008985 active site 1160717008986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1160717008987 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1160717008988 substrate binding site [chemical binding]; other site 1160717008989 oxyanion hole (OAH) forming residues; other site 1160717008990 trimer interface [polypeptide binding]; other site 1160717008991 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1160717008992 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1160717008993 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1160717008994 dimer interface [polypeptide binding]; other site 1160717008995 tetramer interface [polypeptide binding]; other site 1160717008996 PYR/PP interface [polypeptide binding]; other site 1160717008997 TPP binding site [chemical binding]; other site 1160717008998 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1160717008999 TPP-binding site; other site 1160717009000 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1160717009001 isochorismate synthases; Region: isochor_syn; TIGR00543 1160717009002 hypothetical protein; Provisional; Region: PRK10404 1160717009003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717009004 Coenzyme A binding pocket [chemical binding]; other site 1160717009005 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1160717009006 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1160717009007 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1160717009008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717009009 active site 1160717009010 phosphorylation site [posttranslational modification] 1160717009011 intermolecular recognition site; other site 1160717009012 dimerization interface [polypeptide binding]; other site 1160717009013 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1160717009014 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1160717009015 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1160717009016 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1160717009017 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1160717009018 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1160717009019 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1160717009020 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1160717009021 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1160717009022 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1160717009023 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1160717009024 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717009025 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717009026 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1160717009027 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1160717009028 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1160717009029 catalytic loop [active] 1160717009030 iron binding site [ion binding]; other site 1160717009031 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1160717009032 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1160717009033 [4Fe-4S] binding site [ion binding]; other site 1160717009034 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1160717009035 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1160717009036 SLBB domain; Region: SLBB; pfam10531 1160717009037 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1160717009038 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1160717009039 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1160717009040 putative dimer interface [polypeptide binding]; other site 1160717009041 [2Fe-2S] cluster binding site [ion binding]; other site 1160717009042 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1160717009043 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1160717009044 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1160717009045 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1160717009046 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1160717009047 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1160717009048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717009049 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1160717009050 putative dimerization interface [polypeptide binding]; other site 1160717009051 aminotransferase AlaT; Validated; Region: PRK09265 1160717009052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717009053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717009054 homodimer interface [polypeptide binding]; other site 1160717009055 catalytic residue [active] 1160717009056 5'-nucleotidase; Provisional; Region: PRK03826 1160717009057 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1160717009058 transmembrane helices; other site 1160717009059 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1160717009060 TrkA-C domain; Region: TrkA_C; pfam02080 1160717009061 TrkA-C domain; Region: TrkA_C; pfam02080 1160717009062 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1160717009063 putative phosphatase; Provisional; Region: PRK11587 1160717009064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717009065 motif II; other site 1160717009066 hypothetical protein; Validated; Region: PRK05445 1160717009067 hypothetical protein; Provisional; Region: PRK01816 1160717009068 propionate/acetate kinase; Provisional; Region: PRK12379 1160717009069 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1160717009070 phosphate acetyltransferase; Reviewed; Region: PRK05632 1160717009071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1160717009072 DRTGG domain; Region: DRTGG; pfam07085 1160717009073 phosphate acetyltransferase; Region: pta; TIGR00651 1160717009074 hypothetical protein; Provisional; Region: PRK11588 1160717009075 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1160717009076 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1160717009077 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1160717009078 PYR/PP interface [polypeptide binding]; other site 1160717009079 dimer interface [polypeptide binding]; other site 1160717009080 TPP binding site [chemical binding]; other site 1160717009081 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1160717009082 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1160717009083 TPP-binding site [chemical binding]; other site 1160717009084 dimer interface [polypeptide binding]; other site 1160717009085 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1160717009086 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1160717009087 active site 1160717009088 P-loop; other site 1160717009089 phosphorylation site [posttranslational modification] 1160717009090 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717009091 active site 1160717009092 phosphorylation site [posttranslational modification] 1160717009093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1160717009094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717009095 DNA binding site [nucleotide binding] 1160717009096 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1160717009097 putative dimerization interface [polypeptide binding]; other site 1160717009098 putative ligand binding site [chemical binding]; other site 1160717009099 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1160717009100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1160717009101 nudix motif; other site 1160717009102 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1160717009103 active site 1160717009104 metal binding site [ion binding]; metal-binding site 1160717009105 homotetramer interface [polypeptide binding]; other site 1160717009106 glutathione S-transferase; Provisional; Region: PRK15113 1160717009107 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1160717009108 C-terminal domain interface [polypeptide binding]; other site 1160717009109 GSH binding site (G-site) [chemical binding]; other site 1160717009110 dimer interface [polypeptide binding]; other site 1160717009111 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1160717009112 N-terminal domain interface [polypeptide binding]; other site 1160717009113 putative dimer interface [polypeptide binding]; other site 1160717009114 putative substrate binding pocket (H-site) [chemical binding]; other site 1160717009115 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1160717009116 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1160717009117 C-terminal domain interface [polypeptide binding]; other site 1160717009118 GSH binding site (G-site) [chemical binding]; other site 1160717009119 dimer interface [polypeptide binding]; other site 1160717009120 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1160717009121 N-terminal domain interface [polypeptide binding]; other site 1160717009122 putative dimer interface [polypeptide binding]; other site 1160717009123 active site 1160717009124 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1160717009125 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1160717009126 putative NAD(P) binding site [chemical binding]; other site 1160717009127 putative active site [active] 1160717009128 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1160717009129 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1160717009130 Walker A/P-loop; other site 1160717009131 ATP binding site [chemical binding]; other site 1160717009132 Q-loop/lid; other site 1160717009133 ABC transporter signature motif; other site 1160717009134 Walker B; other site 1160717009135 D-loop; other site 1160717009136 H-loop/switch region; other site 1160717009137 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717009138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717009139 dimer interface [polypeptide binding]; other site 1160717009140 conserved gate region; other site 1160717009141 putative PBP binding loops; other site 1160717009142 ABC-ATPase subunit interface; other site 1160717009143 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1160717009144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717009145 dimer interface [polypeptide binding]; other site 1160717009146 conserved gate region; other site 1160717009147 putative PBP binding loops; other site 1160717009148 ABC-ATPase subunit interface; other site 1160717009149 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1160717009150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717009151 substrate binding pocket [chemical binding]; other site 1160717009152 membrane-bound complex binding site; other site 1160717009153 hinge residues; other site 1160717009154 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1160717009155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717009156 substrate binding pocket [chemical binding]; other site 1160717009157 membrane-bound complex binding site; other site 1160717009158 hinge residues; other site 1160717009159 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1160717009160 Flavoprotein; Region: Flavoprotein; pfam02441 1160717009161 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1160717009162 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1160717009163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1160717009164 dimer interface [polypeptide binding]; other site 1160717009165 active site 1160717009166 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717009167 substrate binding site [chemical binding]; other site 1160717009168 catalytic residue [active] 1160717009169 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1160717009170 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1160717009171 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1160717009172 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717009173 catalytic residue [active] 1160717009174 PAS fold; Region: PAS_4; pfam08448 1160717009175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1160717009176 putative active site [active] 1160717009177 heme pocket [chemical binding]; other site 1160717009178 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1160717009179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717009180 Walker A motif; other site 1160717009181 ATP binding site [chemical binding]; other site 1160717009182 Walker B motif; other site 1160717009183 arginine finger; other site 1160717009184 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1160717009185 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1160717009186 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1160717009187 active site 1160717009188 tetramer interface [polypeptide binding]; other site 1160717009189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717009190 active site 1160717009191 colicin V production protein; Provisional; Region: PRK10845 1160717009192 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1160717009193 cell division protein DedD; Provisional; Region: PRK11633 1160717009194 Sporulation related domain; Region: SPOR; pfam05036 1160717009195 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1160717009196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1160717009197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1160717009198 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1160717009199 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1160717009200 hypothetical protein; Provisional; Region: PRK10847 1160717009201 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1160717009202 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1160717009203 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1160717009204 dimerization interface 3.5A [polypeptide binding]; other site 1160717009205 active site 1160717009206 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1160717009207 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1160717009208 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1160717009209 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1160717009210 ligand binding site [chemical binding]; other site 1160717009211 NAD binding site [chemical binding]; other site 1160717009212 catalytic site [active] 1160717009213 homodimer interface [polypeptide binding]; other site 1160717009214 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1160717009215 putative transporter; Provisional; Region: PRK12382 1160717009216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009217 putative substrate translocation pore; other site 1160717009218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717009219 non-specific DNA binding site [nucleotide binding]; other site 1160717009220 salt bridge; other site 1160717009221 sequence-specific DNA binding site [nucleotide binding]; other site 1160717009222 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1160717009223 CAAX protease self-immunity; Region: Abi; pfam02517 1160717009224 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1160717009225 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1160717009226 dimer interface [polypeptide binding]; other site 1160717009227 active site 1160717009228 YfcL protein; Region: YfcL; pfam08891 1160717009229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1160717009230 hypothetical protein; Provisional; Region: PRK10621 1160717009231 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1160717009232 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1160717009233 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1160717009234 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1160717009235 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1160717009236 Tetramer interface [polypeptide binding]; other site 1160717009237 active site 1160717009238 FMN-binding site [chemical binding]; other site 1160717009239 HemK family putative methylases; Region: hemK_fam; TIGR00536 1160717009240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717009241 S-adenosylmethionine binding site [chemical binding]; other site 1160717009242 hypothetical protein; Provisional; Region: PRK04946 1160717009243 Smr domain; Region: Smr; pfam01713 1160717009244 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1160717009245 catalytic core [active] 1160717009246 genomic island 1160717009247 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1160717009248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1160717009249 substrate binding site [chemical binding]; other site 1160717009250 oxyanion hole (OAH) forming residues; other site 1160717009251 trimer interface [polypeptide binding]; other site 1160717009252 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1160717009253 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1160717009254 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1160717009255 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1160717009256 dimer interface [polypeptide binding]; other site 1160717009257 active site 1160717009258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1160717009259 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1160717009260 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1160717009261 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1160717009262 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1160717009263 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1160717009264 active site 1160717009265 Int/Topo IB signature motif; other site 1160717009266 AIPR protein; Region: AIPR; pfam10592 1160717009267 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1160717009268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1160717009269 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1160717009270 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1160717009271 active site 1160717009272 metal binding site [ion binding]; metal-binding site 1160717009273 interdomain interaction site; other site 1160717009274 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1160717009275 Ash protein family; Region: Phage_ASH; pfam10554 1160717009276 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1160717009277 outer membrane protease; Reviewed; Region: PRK10993 1160717009278 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1160717009279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717009280 active site 1160717009281 phosphorylation site [posttranslational modification] 1160717009282 intermolecular recognition site; other site 1160717009283 dimerization interface [polypeptide binding]; other site 1160717009284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1160717009285 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1160717009286 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1160717009287 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1160717009288 dimerization interface [polypeptide binding]; other site 1160717009289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717009290 dimer interface [polypeptide binding]; other site 1160717009291 phosphorylation site [posttranslational modification] 1160717009292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717009293 ATP binding site [chemical binding]; other site 1160717009294 Mg2+ binding site [ion binding]; other site 1160717009295 G-X-G motif; other site 1160717009296 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1160717009297 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1160717009298 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1160717009299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009301 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1160717009302 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1160717009303 aminotransferase; Validated; Region: PRK08175 1160717009304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717009305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717009306 homodimer interface [polypeptide binding]; other site 1160717009307 catalytic residue [active] 1160717009308 glucokinase; Provisional; Region: glk; PRK00292 1160717009309 glucokinase, proteobacterial type; Region: glk; TIGR00749 1160717009310 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1160717009311 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1160717009312 Cl- selectivity filter; other site 1160717009313 Cl- binding residues [ion binding]; other site 1160717009314 pore gating glutamate residue; other site 1160717009315 dimer interface [polypeptide binding]; other site 1160717009316 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1160717009317 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1160717009318 dimer interface [polypeptide binding]; other site 1160717009319 PYR/PP interface [polypeptide binding]; other site 1160717009320 TPP binding site [chemical binding]; other site 1160717009321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1160717009322 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1160717009323 TPP-binding site [chemical binding]; other site 1160717009324 dimer interface [polypeptide binding]; other site 1160717009325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717009326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717009327 active site 1160717009328 catalytic tetrad [active] 1160717009329 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1160717009330 manganese transport protein MntH; Reviewed; Region: PRK00701 1160717009331 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1160717009332 MASE1; Region: MASE1; pfam05231 1160717009333 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1160717009334 diguanylate cyclase; Region: GGDEF; smart00267 1160717009335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717009336 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1160717009337 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1160717009338 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1160717009339 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1160717009340 active site 1160717009341 HIGH motif; other site 1160717009342 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1160717009343 active site 1160717009344 KMSKS motif; other site 1160717009345 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1160717009346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717009347 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1160717009348 putative dimerization interface [polypeptide binding]; other site 1160717009349 putative substrate binding pocket [chemical binding]; other site 1160717009350 XapX domain; Region: XapX; TIGR03510 1160717009351 nucleoside transporter; Region: 2A0110; TIGR00889 1160717009352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009353 putative substrate translocation pore; other site 1160717009354 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1160717009355 hypothetical protein; Provisional; Region: PRK11528 1160717009356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717009357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717009358 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1160717009359 putative dimerization interface [polypeptide binding]; other site 1160717009360 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1160717009361 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1160717009362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1160717009363 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1160717009364 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1160717009365 nucleotide binding pocket [chemical binding]; other site 1160717009366 K-X-D-G motif; other site 1160717009367 catalytic site [active] 1160717009368 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1160717009369 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1160717009370 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1160717009371 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1160717009372 Dimer interface [polypeptide binding]; other site 1160717009373 BRCT sequence motif; other site 1160717009374 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1160717009375 cell division protein ZipA; Provisional; Region: PRK03427 1160717009376 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1160717009377 FtsZ protein binding site [polypeptide binding]; other site 1160717009378 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1160717009379 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1160717009380 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1160717009381 dimer interface [polypeptide binding]; other site 1160717009382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717009383 catalytic residue [active] 1160717009384 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1160717009385 dimerization domain swap beta strand [polypeptide binding]; other site 1160717009386 regulatory protein interface [polypeptide binding]; other site 1160717009387 active site 1160717009388 regulatory phosphorylation site [posttranslational modification]; other site 1160717009389 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1160717009390 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1160717009391 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1160717009392 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1160717009393 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1160717009394 HPr interaction site; other site 1160717009395 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1160717009396 active site 1160717009397 phosphorylation site [posttranslational modification] 1160717009398 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1160717009399 dimer interface [polypeptide binding]; other site 1160717009400 pyridoxamine kinase; Validated; Region: PRK05756 1160717009401 pyridoxal binding site [chemical binding]; other site 1160717009402 ATP binding site [chemical binding]; other site 1160717009403 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1160717009404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717009405 DNA-binding site [nucleotide binding]; DNA binding site 1160717009406 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717009407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717009408 homodimer interface [polypeptide binding]; other site 1160717009409 catalytic residue [active] 1160717009410 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1160717009411 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1160717009412 catalytic triad [active] 1160717009413 hypothetical protein; Provisional; Region: PRK10318 1160717009414 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1160717009415 Sel1-like repeats; Region: SEL1; smart00671 1160717009416 cysteine synthase B; Region: cysM; TIGR01138 1160717009417 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1160717009418 dimer interface [polypeptide binding]; other site 1160717009419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717009420 catalytic residue [active] 1160717009421 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1160717009422 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1160717009423 Walker A/P-loop; other site 1160717009424 ATP binding site [chemical binding]; other site 1160717009425 Q-loop/lid; other site 1160717009426 ABC transporter signature motif; other site 1160717009427 Walker B; other site 1160717009428 D-loop; other site 1160717009429 H-loop/switch region; other site 1160717009430 TOBE-like domain; Region: TOBE_3; pfam12857 1160717009431 sulfate transport protein; Provisional; Region: cysT; CHL00187 1160717009432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717009433 dimer interface [polypeptide binding]; other site 1160717009434 conserved gate region; other site 1160717009435 putative PBP binding loops; other site 1160717009436 ABC-ATPase subunit interface; other site 1160717009437 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1160717009438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717009439 dimer interface [polypeptide binding]; other site 1160717009440 conserved gate region; other site 1160717009441 putative PBP binding loops; other site 1160717009442 ABC-ATPase subunit interface; other site 1160717009443 thiosulfate transporter subunit; Provisional; Region: PRK10852 1160717009444 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1160717009445 short chain dehydrogenase; Provisional; Region: PRK08226 1160717009446 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1160717009447 NAD binding site [chemical binding]; other site 1160717009448 homotetramer interface [polypeptide binding]; other site 1160717009449 homodimer interface [polypeptide binding]; other site 1160717009450 active site 1160717009451 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1160717009452 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1160717009453 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1160717009454 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1160717009455 putative acetyltransferase; Provisional; Region: PRK03624 1160717009456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717009457 Coenzyme A binding pocket [chemical binding]; other site 1160717009458 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1160717009459 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1160717009460 active site 1160717009461 metal binding site [ion binding]; metal-binding site 1160717009462 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1160717009463 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1160717009464 transcriptional regulator EutR; Provisional; Region: PRK10130 1160717009465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717009466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717009467 carboxysome structural protein EutK; Provisional; Region: PRK15466 1160717009468 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1160717009469 Hexamer interface [polypeptide binding]; other site 1160717009470 Hexagonal pore residue; other site 1160717009471 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1160717009472 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1160717009473 putative hexamer interface [polypeptide binding]; other site 1160717009474 putative hexagonal pore; other site 1160717009475 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1160717009476 putative hexamer interface [polypeptide binding]; other site 1160717009477 putative hexagonal pore; other site 1160717009478 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1160717009479 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1160717009480 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1160717009481 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1160717009482 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1160717009483 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1160717009484 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1160717009485 active site 1160717009486 metal binding site [ion binding]; metal-binding site 1160717009487 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1160717009488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717009489 nucleotide binding site [chemical binding]; other site 1160717009490 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1160717009491 putative catalytic cysteine [active] 1160717009492 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1160717009493 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1160717009494 Hexamer interface [polypeptide binding]; other site 1160717009495 Putative hexagonal pore residue; other site 1160717009496 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1160717009497 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1160717009498 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1160717009499 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1160717009500 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1160717009501 G1 box; other site 1160717009502 GTP/Mg2+ binding site [chemical binding]; other site 1160717009503 G2 box; other site 1160717009504 Switch I region; other site 1160717009505 G3 box; other site 1160717009506 Switch II region; other site 1160717009507 G4 box; other site 1160717009508 G5 box; other site 1160717009509 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1160717009510 putative hexamer interface [polypeptide binding]; other site 1160717009511 putative hexagonal pore; other site 1160717009512 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1160717009513 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1160717009514 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1160717009515 putative NAD(P) binding site [chemical binding]; other site 1160717009516 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1160717009517 transaldolase-like protein; Provisional; Region: PTZ00411 1160717009518 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1160717009519 active site 1160717009520 dimer interface [polypeptide binding]; other site 1160717009521 catalytic residue [active] 1160717009522 transketolase; Reviewed; Region: PRK12753 1160717009523 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1160717009524 TPP-binding site [chemical binding]; other site 1160717009525 dimer interface [polypeptide binding]; other site 1160717009526 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1160717009527 PYR/PP interface [polypeptide binding]; other site 1160717009528 dimer interface [polypeptide binding]; other site 1160717009529 TPP binding site [chemical binding]; other site 1160717009530 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1160717009531 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1160717009532 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1160717009533 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1160717009534 dimer interface [polypeptide binding]; other site 1160717009535 ADP-ribose binding site [chemical binding]; other site 1160717009536 active site 1160717009537 nudix motif; other site 1160717009538 metal binding site [ion binding]; metal-binding site 1160717009539 putative periplasmic esterase; Provisional; Region: PRK03642 1160717009540 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1160717009541 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1160717009542 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717009543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1160717009544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717009545 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1160717009546 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1160717009547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717009548 dimerization interface [polypeptide binding]; other site 1160717009549 Histidine kinase; Region: HisKA_3; pfam07730 1160717009550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717009551 ATP binding site [chemical binding]; other site 1160717009552 Mg2+ binding site [ion binding]; other site 1160717009553 G-X-G motif; other site 1160717009554 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1160717009555 Protein export membrane protein; Region: SecD_SecF; cl14618 1160717009556 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1160717009557 ArsC family; Region: ArsC; pfam03960 1160717009558 putative catalytic residues [active] 1160717009559 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1160717009560 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1160717009561 metal binding site [ion binding]; metal-binding site 1160717009562 dimer interface [polypeptide binding]; other site 1160717009563 hypothetical protein; Provisional; Region: PRK13664 1160717009564 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1160717009565 Helicase; Region: Helicase_RecD; pfam05127 1160717009566 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1160717009567 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1160717009568 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1160717009569 Predicted metalloprotease [General function prediction only]; Region: COG2321 1160717009570 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1160717009571 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1160717009572 ATP binding site [chemical binding]; other site 1160717009573 active site 1160717009574 substrate binding site [chemical binding]; other site 1160717009575 lipoprotein; Provisional; Region: PRK11679 1160717009576 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1160717009577 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1160717009578 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1160717009579 dimer interface [polypeptide binding]; other site 1160717009580 active site 1160717009581 catalytic residue [active] 1160717009582 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1160717009583 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1160717009584 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1160717009585 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1160717009586 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1160717009587 catalytic triad [active] 1160717009588 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1160717009589 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1160717009590 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1160717009591 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1160717009592 Peptidase family M48; Region: Peptidase_M48; cl12018 1160717009593 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1160717009594 ArsC family; Region: ArsC; pfam03960 1160717009595 catalytic residues [active] 1160717009596 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1160717009597 DNA replication initiation factor; Provisional; Region: PRK08084 1160717009598 uracil transporter; Provisional; Region: PRK10720 1160717009599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717009600 active site 1160717009601 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1160717009602 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1160717009603 dimerization interface [polypeptide binding]; other site 1160717009604 putative ATP binding site [chemical binding]; other site 1160717009605 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1160717009606 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1160717009607 active site 1160717009608 substrate binding site [chemical binding]; other site 1160717009609 cosubstrate binding site; other site 1160717009610 catalytic site [active] 1160717009611 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1160717009612 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1160717009613 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1160717009614 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1160717009615 putative active site [active] 1160717009616 catalytic site [active] 1160717009617 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1160717009618 domain interface [polypeptide binding]; other site 1160717009619 active site 1160717009620 catalytic site [active] 1160717009621 exopolyphosphatase; Provisional; Region: PRK10854 1160717009622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717009623 nucleotide binding site [chemical binding]; other site 1160717009624 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1160717009625 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1160717009626 Integrase core domain; Region: rve; pfam00665 1160717009627 GMP synthase; Reviewed; Region: guaA; PRK00074 1160717009628 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1160717009629 AMP/PPi binding site [chemical binding]; other site 1160717009630 candidate oxyanion hole; other site 1160717009631 catalytic triad [active] 1160717009632 potential glutamine specificity residues [chemical binding]; other site 1160717009633 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1160717009634 ATP Binding subdomain [chemical binding]; other site 1160717009635 Ligand Binding sites [chemical binding]; other site 1160717009636 Dimerization subdomain; other site 1160717009637 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1160717009638 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1160717009639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1160717009640 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1160717009641 active site 1160717009642 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1160717009643 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1160717009644 generic binding surface II; other site 1160717009645 generic binding surface I; other site 1160717009646 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 1160717009647 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1160717009648 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1160717009649 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1160717009650 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1160717009651 Autotransporter beta-domain; Region: Autotransporter; smart00869 1160717009652 outer membrane protein RatB; Provisional; Region: PRK15314 1160717009653 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009654 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009655 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009656 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009657 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009658 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009659 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009660 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009661 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009662 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009663 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009664 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009665 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009666 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009667 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009668 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009669 outer membrane protein RatA; Provisional; Region: PRK15315 1160717009670 Oxygen tolerance; Region: BatD; pfam13584 1160717009671 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009672 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009673 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009674 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009675 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009676 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009677 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009678 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009679 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009680 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1160717009681 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1160717009682 intimin-like protein SinH; Provisional; Region: PRK15318 1160717009683 intimin-like protein SinH; Provisional; Region: PRK15318 1160717009684 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1160717009685 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1160717009686 GTP-binding protein Der; Reviewed; Region: PRK00093 1160717009687 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1160717009688 G1 box; other site 1160717009689 GTP/Mg2+ binding site [chemical binding]; other site 1160717009690 Switch I region; other site 1160717009691 G2 box; other site 1160717009692 Switch II region; other site 1160717009693 G3 box; other site 1160717009694 G4 box; other site 1160717009695 G5 box; other site 1160717009696 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1160717009697 G1 box; other site 1160717009698 GTP/Mg2+ binding site [chemical binding]; other site 1160717009699 Switch I region; other site 1160717009700 G2 box; other site 1160717009701 G3 box; other site 1160717009702 Switch II region; other site 1160717009703 G4 box; other site 1160717009704 G5 box; other site 1160717009705 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1160717009706 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1160717009707 Trp docking motif [polypeptide binding]; other site 1160717009708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1160717009709 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1160717009710 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1160717009711 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1160717009712 dimer interface [polypeptide binding]; other site 1160717009713 motif 1; other site 1160717009714 active site 1160717009715 motif 2; other site 1160717009716 motif 3; other site 1160717009717 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1160717009718 anticodon binding site; other site 1160717009719 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1160717009720 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1160717009721 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1160717009722 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1160717009723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717009724 non-specific DNA binding site [nucleotide binding]; other site 1160717009725 salt bridge; other site 1160717009726 sequence-specific DNA binding site [nucleotide binding]; other site 1160717009727 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1160717009728 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1160717009729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717009730 FeS/SAM binding site; other site 1160717009731 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1160717009732 active site 1160717009733 multimer interface [polypeptide binding]; other site 1160717009734 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717009735 hydrogenase 4 subunit H; Validated; Region: PRK08222 1160717009736 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1160717009737 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1160717009738 4Fe-4S binding domain; Region: Fer4; pfam00037 1160717009739 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1160717009740 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1160717009741 putative [Fe4-S4] binding site [ion binding]; other site 1160717009742 putative molybdopterin cofactor binding site [chemical binding]; other site 1160717009743 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1160717009744 putative molybdopterin cofactor binding site; other site 1160717009745 penicillin-binding protein 1C; Provisional; Region: PRK11240 1160717009746 Transglycosylase; Region: Transgly; pfam00912 1160717009747 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1160717009748 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1160717009749 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1160717009750 MG2 domain; Region: A2M_N; pfam01835 1160717009751 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1160717009752 surface patch; other site 1160717009753 thioester region; other site 1160717009754 specificity defining residues; other site 1160717009755 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1160717009756 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1160717009757 active site residue [active] 1160717009758 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1160717009759 active site residue [active] 1160717009760 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1160717009761 aminopeptidase B; Provisional; Region: PRK05015 1160717009762 Peptidase; Region: DUF3663; pfam12404 1160717009763 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1160717009764 interface (dimer of trimers) [polypeptide binding]; other site 1160717009765 Substrate-binding/catalytic site; other site 1160717009766 Zn-binding sites [ion binding]; other site 1160717009767 hypothetical protein; Provisional; Region: PRK10721 1160717009768 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1160717009769 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1160717009770 catalytic loop [active] 1160717009771 iron binding site [ion binding]; other site 1160717009772 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1160717009773 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1160717009774 nucleotide binding site [chemical binding]; other site 1160717009775 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1160717009776 SBD interface [polypeptide binding]; other site 1160717009777 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1160717009778 DnaJ domain; Region: DnaJ; pfam00226 1160717009779 HSP70 interaction site [polypeptide binding]; other site 1160717009780 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1160717009781 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1160717009782 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1160717009783 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1160717009784 trimerization site [polypeptide binding]; other site 1160717009785 active site 1160717009786 cysteine desulfurase; Provisional; Region: PRK14012 1160717009787 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1160717009788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717009789 catalytic residue [active] 1160717009790 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1160717009791 Rrf2 family protein; Region: rrf2_super; TIGR00738 1160717009792 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1160717009793 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1160717009794 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1160717009795 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1160717009796 active site 1160717009797 dimerization interface [polypeptide binding]; other site 1160717009798 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1160717009799 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1160717009800 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 1160717009801 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717009802 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1160717009803 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1160717009804 FAD binding pocket [chemical binding]; other site 1160717009805 FAD binding motif [chemical binding]; other site 1160717009806 phosphate binding motif [ion binding]; other site 1160717009807 beta-alpha-beta structure motif; other site 1160717009808 NAD binding pocket [chemical binding]; other site 1160717009809 Iron coordination center [ion binding]; other site 1160717009810 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 1160717009811 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1160717009812 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717009813 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1160717009814 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1160717009815 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1160717009816 PRD domain; Region: PRD; pfam00874 1160717009817 PRD domain; Region: PRD; pfam00874 1160717009818 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1160717009819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009820 putative substrate translocation pore; other site 1160717009821 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1160717009822 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1160717009823 dimer interface [polypeptide binding]; other site 1160717009824 active site 1160717009825 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1160717009826 folate binding site [chemical binding]; other site 1160717009827 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1160717009828 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1160717009829 heme-binding site [chemical binding]; other site 1160717009830 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1160717009831 FAD binding pocket [chemical binding]; other site 1160717009832 FAD binding motif [chemical binding]; other site 1160717009833 phosphate binding motif [ion binding]; other site 1160717009834 beta-alpha-beta structure motif; other site 1160717009835 NAD binding pocket [chemical binding]; other site 1160717009836 Heme binding pocket [chemical binding]; other site 1160717009837 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1160717009838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717009839 DNA binding site [nucleotide binding] 1160717009840 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1160717009841 lysine decarboxylase CadA; Provisional; Region: PRK15400 1160717009842 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1160717009843 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1160717009844 homodimer interface [polypeptide binding]; other site 1160717009845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717009846 catalytic residue [active] 1160717009847 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1160717009848 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1160717009849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009850 putative substrate translocation pore; other site 1160717009851 POT family; Region: PTR2; pfam00854 1160717009852 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1160717009853 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1160717009854 response regulator GlrR; Provisional; Region: PRK15115 1160717009855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717009856 active site 1160717009857 phosphorylation site [posttranslational modification] 1160717009858 intermolecular recognition site; other site 1160717009859 dimerization interface [polypeptide binding]; other site 1160717009860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717009861 Walker A motif; other site 1160717009862 ATP binding site [chemical binding]; other site 1160717009863 Walker B motif; other site 1160717009864 arginine finger; other site 1160717009865 hypothetical protein; Provisional; Region: PRK10722 1160717009866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1160717009867 HAMP domain; Region: HAMP; pfam00672 1160717009868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717009869 dimer interface [polypeptide binding]; other site 1160717009870 phosphorylation site [posttranslational modification] 1160717009871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717009872 ATP binding site [chemical binding]; other site 1160717009873 Mg2+ binding site [ion binding]; other site 1160717009874 G-X-G motif; other site 1160717009875 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1160717009876 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1160717009877 dimerization interface [polypeptide binding]; other site 1160717009878 ATP binding site [chemical binding]; other site 1160717009879 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 1160717009880 dimerization interface [polypeptide binding]; other site 1160717009881 ATP binding site [chemical binding]; other site 1160717009882 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1160717009883 putative active site [active] 1160717009884 catalytic triad [active] 1160717009885 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1160717009886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717009887 substrate binding pocket [chemical binding]; other site 1160717009888 membrane-bound complex binding site; other site 1160717009889 hinge residues; other site 1160717009890 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717009891 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717009892 catalytic residue [active] 1160717009893 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1160717009894 nucleoside/Zn binding site; other site 1160717009895 dimer interface [polypeptide binding]; other site 1160717009896 catalytic motif [active] 1160717009897 hypothetical protein; Provisional; Region: PRK11590 1160717009898 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1160717009899 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1160717009900 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1160717009901 active site turn [active] 1160717009902 phosphorylation site [posttranslational modification] 1160717009903 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1160717009904 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1160717009905 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1160717009906 putative active site [active] 1160717009907 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1160717009908 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1160717009909 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1160717009910 putative active site [active] 1160717009911 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1160717009912 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1160717009913 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1160717009914 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1160717009915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717009916 putative substrate translocation pore; other site 1160717009917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717009918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717009919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717009920 dimerization interface [polypeptide binding]; other site 1160717009921 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1160717009922 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1160717009923 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1160717009924 active site 1160717009925 hydrophilic channel; other site 1160717009926 dimerization interface [polypeptide binding]; other site 1160717009927 catalytic residues [active] 1160717009928 active site lid [active] 1160717009929 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1160717009930 Recombination protein O N terminal; Region: RecO_N; pfam11967 1160717009931 Recombination protein O C terminal; Region: RecO_C; pfam02565 1160717009932 GTPase Era; Reviewed; Region: era; PRK00089 1160717009933 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1160717009934 G1 box; other site 1160717009935 GTP/Mg2+ binding site [chemical binding]; other site 1160717009936 Switch I region; other site 1160717009937 G2 box; other site 1160717009938 Switch II region; other site 1160717009939 G3 box; other site 1160717009940 G4 box; other site 1160717009941 G5 box; other site 1160717009942 KH domain; Region: KH_2; pfam07650 1160717009943 ribonuclease III; Reviewed; Region: rnc; PRK00102 1160717009944 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1160717009945 dimerization interface [polypeptide binding]; other site 1160717009946 active site 1160717009947 metal binding site [ion binding]; metal-binding site 1160717009948 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1160717009949 dsRNA binding site [nucleotide binding]; other site 1160717009950 signal peptidase I; Provisional; Region: PRK10861 1160717009951 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1160717009952 Catalytic site [active] 1160717009953 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1160717009954 GTP-binding protein LepA; Provisional; Region: PRK05433 1160717009955 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1160717009956 G1 box; other site 1160717009957 putative GEF interaction site [polypeptide binding]; other site 1160717009958 GTP/Mg2+ binding site [chemical binding]; other site 1160717009959 Switch I region; other site 1160717009960 G2 box; other site 1160717009961 G3 box; other site 1160717009962 Switch II region; other site 1160717009963 G4 box; other site 1160717009964 G5 box; other site 1160717009965 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1160717009966 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1160717009967 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1160717009968 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1160717009969 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1160717009970 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1160717009971 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1160717009972 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1160717009973 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1160717009974 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1160717009975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1160717009976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1160717009977 DNA binding residues [nucleotide binding] 1160717009978 L-aspartate oxidase; Provisional; Region: PRK09077 1160717009979 L-aspartate oxidase; Provisional; Region: PRK06175 1160717009980 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1160717009981 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1160717009982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717009983 S-adenosylmethionine binding site [chemical binding]; other site 1160717009984 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1160717009985 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1160717009986 ATP binding site [chemical binding]; other site 1160717009987 Mg++ binding site [ion binding]; other site 1160717009988 motif III; other site 1160717009989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717009990 nucleotide binding region [chemical binding]; other site 1160717009991 ATP-binding site [chemical binding]; other site 1160717009992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717009993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717009994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717009995 dimerization interface [polypeptide binding]; other site 1160717009996 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1160717009997 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1160717009998 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1160717009999 ligand binding site [chemical binding]; other site 1160717010000 active site 1160717010001 UGI interface [polypeptide binding]; other site 1160717010002 catalytic site [active] 1160717010003 thioredoxin 2; Provisional; Region: PRK10996 1160717010004 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1160717010005 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1160717010006 catalytic residues [active] 1160717010007 genomic island 1160717010008 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1160717010009 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1160717010010 CoA binding domain; Region: CoA_binding_2; pfam13380 1160717010011 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1160717010012 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1160717010013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1160717010014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717010015 Coenzyme A binding pocket [chemical binding]; other site 1160717010016 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1160717010017 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1160717010018 domain interface [polypeptide binding]; other site 1160717010019 putative active site [active] 1160717010020 catalytic site [active] 1160717010021 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1160717010022 domain interface [polypeptide binding]; other site 1160717010023 putative active site [active] 1160717010024 catalytic site [active] 1160717010025 lipoprotein; Provisional; Region: PRK10759 1160717010026 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1160717010027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010028 putative substrate translocation pore; other site 1160717010029 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1160717010030 PK-G12rRNA; SU5_nc112 1160717010031 protein disaggregation chaperone; Provisional; Region: PRK10865 1160717010032 Clp amino terminal domain; Region: Clp_N; pfam02861 1160717010033 Clp amino terminal domain; Region: Clp_N; pfam02861 1160717010034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717010035 Walker A motif; other site 1160717010036 ATP binding site [chemical binding]; other site 1160717010037 Walker B motif; other site 1160717010038 arginine finger; other site 1160717010039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717010040 Walker A motif; other site 1160717010041 ATP binding site [chemical binding]; other site 1160717010042 Walker B motif; other site 1160717010043 arginine finger; other site 1160717010044 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1160717010045 hypothetical protein; Provisional; Region: PRK10723 1160717010046 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1160717010047 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1160717010048 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717010049 RNA binding surface [nucleotide binding]; other site 1160717010050 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1160717010051 active site 1160717010052 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1160717010053 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1160717010054 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1160717010055 30S subunit binding site; other site 1160717010056 Phe_leader; SU5_nc114 1160717010057 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1160717010058 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1160717010059 Prephenate dehydratase; Region: PDT; pfam00800 1160717010060 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1160717010061 putative L-Phe binding site [chemical binding]; other site 1160717010062 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1160717010063 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1160717010064 Chorismate mutase type II; Region: CM_2; cl00693 1160717010065 prephenate dehydrogenase; Validated; Region: PRK08507 1160717010066 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1160717010067 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1160717010068 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1160717010069 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1160717010070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717010071 metal binding site [ion binding]; metal-binding site 1160717010072 active site 1160717010073 I-site; other site 1160717010074 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1160717010075 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1160717010076 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1160717010077 RimM N-terminal domain; Region: RimM; pfam01782 1160717010078 PRC-barrel domain; Region: PRC; pfam05239 1160717010079 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1160717010080 signal recognition particle protein; Provisional; Region: PRK10867 1160717010081 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1160717010082 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1160717010083 P loop; other site 1160717010084 GTP binding site [chemical binding]; other site 1160717010085 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1160717010086 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1160717010087 Domain of unknown function DUF21; Region: DUF21; pfam01595 1160717010088 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1160717010089 putative coenzyme Q binding site [chemical binding]; other site 1160717010090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1160717010091 Transporter associated domain; Region: CorC_HlyC; smart01091 1160717010092 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1160717010093 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1160717010094 dimer interface [polypeptide binding]; other site 1160717010095 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1160717010096 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1160717010097 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1160717010098 recombination and repair protein; Provisional; Region: PRK10869 1160717010099 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1160717010100 Walker A/P-loop; other site 1160717010101 ATP binding site [chemical binding]; other site 1160717010102 Q-loop/lid; other site 1160717010103 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1160717010104 ABC transporter signature motif; other site 1160717010105 Walker B; other site 1160717010106 D-loop; other site 1160717010107 H-loop/switch region; other site 1160717010108 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1160717010109 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1160717010110 hypothetical protein; Validated; Region: PRK01777 1160717010111 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1160717010112 putative coenzyme Q binding site [chemical binding]; other site 1160717010113 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1160717010114 SmpB-tmRNA interface; other site 1160717010115 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010116 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010118 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010119 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010120 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010121 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010122 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010123 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010124 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010125 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010126 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717010127 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010128 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010129 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1160717010130 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010131 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1160717010132 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1160717010133 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1160717010134 genomic island 1160717010135 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1160717010136 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717010137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717010138 Walker A/P-loop; other site 1160717010139 ATP binding site [chemical binding]; other site 1160717010140 Q-loop/lid; other site 1160717010141 ABC transporter signature motif; other site 1160717010142 Walker B; other site 1160717010143 D-loop; other site 1160717010144 H-loop/switch region; other site 1160717010145 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1160717010146 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717010147 SEC-C motif; Region: SEC-C; pfam02810 1160717010148 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1160717010149 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1160717010150 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1160717010151 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1160717010152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717010153 non-specific DNA binding site [nucleotide binding]; other site 1160717010154 salt bridge; other site 1160717010155 sequence-specific DNA binding site [nucleotide binding]; other site 1160717010156 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1160717010157 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 1160717010158 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 1160717010159 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1160717010160 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1160717010161 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1160717010162 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1160717010163 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1160717010164 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1160717010165 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1160717010166 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1160717010167 active site 1160717010168 dimer interface [polypeptide binding]; other site 1160717010169 magnesium binding site [ion binding]; other site 1160717010170 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1160717010171 tetramer interface [polypeptide binding]; other site 1160717010172 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1160717010173 active site 1160717010174 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 1160717010175 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1160717010176 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1160717010177 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1160717010178 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1160717010179 active site turn [active] 1160717010180 phosphorylation site [posttranslational modification] 1160717010181 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1160717010182 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1160717010183 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1160717010184 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1160717010185 Integrase; Region: Integrase_1; pfam12835 1160717010186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1160717010187 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1160717010188 DNA-binding interface [nucleotide binding]; DNA binding site 1160717010189 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1160717010190 Family description; Region: UvrD_C_2; pfam13538 1160717010191 Transposase; Region: HTH_Tnp_1; cl17663 1160717010192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1160717010193 putative transposase OrfB; Reviewed; Region: PHA02517 1160717010194 HTH-like domain; Region: HTH_21; pfam13276 1160717010195 Integrase core domain; Region: rve; pfam00665 1160717010196 Integrase core domain; Region: rve_2; pfam13333 1160717010197 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 1160717010198 flagellin; Validated; Region: PRK08026 1160717010199 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1160717010200 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1160717010201 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1160717010202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1160717010203 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1160717010204 catalytic residues [active] 1160717010205 catalytic nucleophile [active] 1160717010206 Presynaptic Site I dimer interface [polypeptide binding]; other site 1160717010207 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1160717010208 Synaptic Flat tetramer interface [polypeptide binding]; other site 1160717010209 Synaptic Site I dimer interface [polypeptide binding]; other site 1160717010210 DNA binding site [nucleotide binding] 1160717010211 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1160717010212 DNA-binding interface [nucleotide binding]; DNA binding site 1160717010213 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1160717010214 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1160717010215 homodimer interface [polypeptide binding]; other site 1160717010216 active site 1160717010217 TDP-binding site; other site 1160717010218 acceptor substrate-binding pocket; other site 1160717010219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717010220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717010221 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1160717010222 Walker A/P-loop; other site 1160717010223 ATP binding site [chemical binding]; other site 1160717010224 Q-loop/lid; other site 1160717010225 ABC transporter signature motif; other site 1160717010226 Walker B; other site 1160717010227 D-loop; other site 1160717010228 H-loop/switch region; other site 1160717010229 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1160717010230 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1160717010231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717010232 Walker A/P-loop; other site 1160717010233 ATP binding site [chemical binding]; other site 1160717010234 Q-loop/lid; other site 1160717010235 ABC transporter signature motif; other site 1160717010236 Walker B; other site 1160717010237 D-loop; other site 1160717010238 H-loop/switch region; other site 1160717010239 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1160717010240 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1160717010241 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1160717010242 genomic island 1160717010243 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1160717010244 outer membrane receptor FepA; Provisional; Region: PRK13528 1160717010245 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1160717010246 N-terminal plug; other site 1160717010247 ligand-binding site [chemical binding]; other site 1160717010248 secreted effector protein PipB2; Provisional; Region: PRK15196 1160717010249 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717010250 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717010251 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717010252 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717010253 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1160717010254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1160717010255 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1160717010256 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1160717010257 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1160717010258 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1160717010259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1160717010260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1160717010261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717010262 dimer interface [polypeptide binding]; other site 1160717010263 phosphorylation site [posttranslational modification] 1160717010264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717010265 ATP binding site [chemical binding]; other site 1160717010266 Mg2+ binding site [ion binding]; other site 1160717010267 G-X-G motif; other site 1160717010268 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1160717010269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717010270 active site 1160717010271 phosphorylation site [posttranslational modification] 1160717010272 intermolecular recognition site; other site 1160717010273 dimerization interface [polypeptide binding]; other site 1160717010274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717010275 DNA binding site [nucleotide binding] 1160717010276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1160717010277 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1160717010278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1160717010279 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1160717010280 substrate binding pocket [chemical binding]; other site 1160717010281 active site 1160717010282 iron coordination sites [ion binding]; other site 1160717010283 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1160717010284 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1160717010285 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1160717010286 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1160717010287 tetramerization interface [polypeptide binding]; other site 1160717010288 NAD(P) binding site [chemical binding]; other site 1160717010289 catalytic residues [active] 1160717010290 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1160717010291 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1160717010292 inhibitor-cofactor binding pocket; inhibition site 1160717010293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717010294 catalytic residue [active] 1160717010295 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1160717010296 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1160717010297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717010298 DNA-binding site [nucleotide binding]; DNA binding site 1160717010299 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1160717010300 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1160717010301 bacterial OsmY and nodulation domain; Region: BON; smart00749 1160717010302 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717010303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717010304 dimerization interface [polypeptide binding]; other site 1160717010305 putative DNA binding site [nucleotide binding]; other site 1160717010306 putative Zn2+ binding site [ion binding]; other site 1160717010307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1160717010308 active site residue [active] 1160717010309 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1160717010310 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1160717010311 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1160717010312 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1160717010313 hypothetical protein; Provisional; Region: PRK10556 1160717010314 hypothetical protein; Provisional; Region: PRK10132 1160717010315 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1160717010316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717010317 DNA-binding site [nucleotide binding]; DNA binding site 1160717010318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717010319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717010320 homodimer interface [polypeptide binding]; other site 1160717010321 catalytic residue [active] 1160717010322 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1160717010323 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1160717010324 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1160717010325 catalytic residues [active] 1160717010326 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1160717010327 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1160717010328 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1160717010329 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1160717010330 active site 1160717010331 dimer interface [polypeptide binding]; other site 1160717010332 catalytic residues [active] 1160717010333 effector binding site; other site 1160717010334 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1160717010335 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1160717010336 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1160717010337 dimer interface [polypeptide binding]; other site 1160717010338 putative radical transfer pathway; other site 1160717010339 diiron center [ion binding]; other site 1160717010340 tyrosyl radical; other site 1160717010341 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1160717010342 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1160717010343 Walker A/P-loop; other site 1160717010344 ATP binding site [chemical binding]; other site 1160717010345 Q-loop/lid; other site 1160717010346 ABC transporter signature motif; other site 1160717010347 Walker B; other site 1160717010348 D-loop; other site 1160717010349 H-loop/switch region; other site 1160717010350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1160717010351 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1160717010352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717010353 dimer interface [polypeptide binding]; other site 1160717010354 conserved gate region; other site 1160717010355 putative PBP binding loops; other site 1160717010356 ABC-ATPase subunit interface; other site 1160717010357 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1160717010358 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1160717010359 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1160717010360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010361 transcriptional repressor MprA; Provisional; Region: PRK10870 1160717010362 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1160717010363 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1160717010364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717010365 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717010366 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1160717010367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010368 putative substrate translocation pore; other site 1160717010369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010370 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1160717010371 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1160717010372 glutamate--cysteine ligase; Provisional; Region: PRK02107 1160717010373 Predicted membrane protein [Function unknown]; Region: COG1238 1160717010374 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1160717010375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717010376 motif II; other site 1160717010377 O-methyltransferase; Region: Methyltransf_2; pfam00891 1160717010378 carbon storage regulator; Provisional; Region: PRK01712 1160717010379 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1160717010380 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1160717010381 motif 1; other site 1160717010382 active site 1160717010383 motif 2; other site 1160717010384 motif 3; other site 1160717010385 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1160717010386 DHHA1 domain; Region: DHHA1; pfam02272 1160717010387 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1160717010388 recombinase A; Provisional; Region: recA; PRK09354 1160717010389 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1160717010390 hexamer interface [polypeptide binding]; other site 1160717010391 Walker A motif; other site 1160717010392 ATP binding site [chemical binding]; other site 1160717010393 Walker B motif; other site 1160717010394 hypothetical protein; Validated; Region: PRK03661 1160717010395 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1160717010396 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717010397 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717010398 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1160717010399 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1160717010400 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1160717010401 Nucleoside recognition; Region: Gate; pfam07670 1160717010402 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1160717010403 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1160717010404 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1160717010405 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1160717010406 putative NAD(P) binding site [chemical binding]; other site 1160717010407 active site 1160717010408 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1160717010409 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1160717010410 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1160717010411 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717010412 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1160717010413 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1160717010414 putative active site [active] 1160717010415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1160717010416 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1160717010417 GAF domain; Region: GAF; pfam01590 1160717010418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717010419 Walker A motif; other site 1160717010420 ATP binding site [chemical binding]; other site 1160717010421 Walker B motif; other site 1160717010422 arginine finger; other site 1160717010423 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1160717010424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1160717010425 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1160717010426 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1160717010427 iron binding site [ion binding]; other site 1160717010428 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1160717010429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717010430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717010431 Acylphosphatase; Region: Acylphosphatase; pfam00708 1160717010432 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1160717010433 HypF finger; Region: zf-HYPF; pfam07503 1160717010434 HypF finger; Region: zf-HYPF; pfam07503 1160717010435 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1160717010436 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1160717010437 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1160717010438 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1160717010439 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1160717010440 nickel binding site [ion binding]; other site 1160717010441 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1160717010442 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1160717010443 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1160717010444 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1160717010445 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1160717010446 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1160717010447 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1160717010448 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1160717010449 NADH dehydrogenase; Region: NADHdh; cl00469 1160717010450 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1160717010451 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1160717010452 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1160717010453 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1160717010454 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1160717010455 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1160717010456 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1160717010457 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1160717010458 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1160717010459 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1160717010460 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1160717010461 dimerization interface [polypeptide binding]; other site 1160717010462 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1160717010463 ATP binding site [chemical binding]; other site 1160717010464 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1160717010465 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1160717010466 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1160717010467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717010468 Walker A motif; other site 1160717010469 ATP binding site [chemical binding]; other site 1160717010470 Walker B motif; other site 1160717010471 arginine finger; other site 1160717010472 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1160717010473 genomic island 1160717010474 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1160717010475 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1160717010476 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1160717010477 metal binding site [ion binding]; metal-binding site 1160717010478 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1160717010479 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1160717010480 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1160717010481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717010482 ABC-ATPase subunit interface; other site 1160717010483 dimer interface [polypeptide binding]; other site 1160717010484 putative PBP binding regions; other site 1160717010485 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1160717010486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1160717010487 ABC-ATPase subunit interface; other site 1160717010488 dimer interface [polypeptide binding]; other site 1160717010489 putative PBP binding regions; other site 1160717010490 effector protein YopJ; Provisional; Region: PRK15371 1160717010491 transcriptional activator SprB; Provisional; Region: PRK15320 1160717010492 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1160717010493 transcriptional regulator SirC; Provisional; Region: PRK15044 1160717010494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717010495 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 1160717010496 invasion protein OrgB; Provisional; Region: PRK15322 1160717010497 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1160717010498 invasion protein OrgA; Provisional; Region: PRK15323 1160717010499 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 1160717010500 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1160717010501 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 1160717010502 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 1160717010503 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1160717010504 transcriptional regulator HilD; Provisional; Region: PRK15185 1160717010505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717010506 invasion protein regulator; Provisional; Region: PRK12370 1160717010507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717010508 DNA binding site [nucleotide binding] 1160717010509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1160717010510 binding surface 1160717010511 TPR motif; other site 1160717010512 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1160717010513 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717010514 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717010515 catalytic residue [active] 1160717010516 chaperone protein SicP; Provisional; Region: PRK15329 1160717010517 putative acyl carrier protein IacP; Validated; Region: PRK08172 1160717010518 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 1160717010519 cell invasion protein SipD; Provisional; Region: PRK15330 1160717010520 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 1160717010521 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1160717010522 chaperone protein SicA; Provisional; Region: PRK15331 1160717010523 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1160717010524 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1160717010525 type III secretion system protein SpaS; Validated; Region: PRK08156 1160717010526 type III secretion system protein SpaR; Provisional; Region: PRK15332 1160717010527 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1160717010528 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1160717010529 type III secretion system protein SpaO; Validated; Region: PRK08158 1160717010530 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1160717010531 antigen presentation protein SpaN; Provisional; Region: PRK15334 1160717010532 Surface presentation of antigens protein; Region: SPAN; pfam02510 1160717010533 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 1160717010534 ATP synthase SpaL; Validated; Region: PRK08149 1160717010535 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1160717010536 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1160717010537 Walker A motif; other site 1160717010538 ATP binding site [chemical binding]; other site 1160717010539 Walker B motif; other site 1160717010540 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 1160717010541 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1160717010542 type III secretion system protein InvA; Provisional; Region: PRK15337 1160717010543 type III secretion system regulator InvE; Provisional; Region: PRK15338 1160717010544 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1160717010545 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1160717010546 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1160717010547 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1160717010548 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1160717010549 transcriptional regulator InvF; Provisional; Region: PRK15340 1160717010550 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1160717010551 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1160717010552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1160717010553 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1160717010554 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1160717010555 active site 1160717010556 metal binding site [ion binding]; metal-binding site 1160717010557 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1160717010558 MutS domain I; Region: MutS_I; pfam01624 1160717010559 MutS domain II; Region: MutS_II; pfam05188 1160717010560 MutS domain III; Region: MutS_III; pfam05192 1160717010561 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1160717010562 Walker A/P-loop; other site 1160717010563 ATP binding site [chemical binding]; other site 1160717010564 Q-loop/lid; other site 1160717010565 ABC transporter signature motif; other site 1160717010566 Walker B; other site 1160717010567 D-loop; other site 1160717010568 H-loop/switch region; other site 1160717010569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1160717010570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1160717010572 putative substrate translocation pore; other site 1160717010573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717010574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717010575 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1160717010576 putative effector binding pocket; other site 1160717010577 dimerization interface [polypeptide binding]; other site 1160717010578 GntP family permease; Region: GntP_permease; pfam02447 1160717010579 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1160717010580 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1160717010581 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1160717010582 putative NAD(P) binding site [chemical binding]; other site 1160717010583 active site 1160717010584 putative substrate binding site [chemical binding]; other site 1160717010585 hypothetical protein; Provisional; Region: PRK09989 1160717010586 putative aldolase; Validated; Region: PRK08130 1160717010587 intersubunit interface [polypeptide binding]; other site 1160717010588 active site 1160717010589 Zn2+ binding site [ion binding]; other site 1160717010590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1160717010591 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1160717010592 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1160717010593 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717010594 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717010595 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717010596 MarR family; Region: MarR_2; cl17246 1160717010597 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1160717010598 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1160717010599 Flavoprotein; Region: Flavoprotein; pfam02441 1160717010600 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1160717010601 RNA polymerase sigma factor RpoS pseudogene 1160717010602 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1160717010603 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717010604 Peptidase family M23; Region: Peptidase_M23; pfam01551 1160717010605 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1160717010606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717010607 S-adenosylmethionine binding site [chemical binding]; other site 1160717010608 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1160717010609 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1160717010610 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1160717010611 Permutation of conserved domain; other site 1160717010612 active site 1160717010613 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1160717010614 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1160717010615 homotrimer interaction site [polypeptide binding]; other site 1160717010616 zinc binding site [ion binding]; other site 1160717010617 CDP-binding sites; other site 1160717010618 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1160717010619 substrate binding site; other site 1160717010620 dimer interface; other site 1160717010621 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1160717010622 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1160717010623 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1160717010624 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1160717010625 ligand-binding site [chemical binding]; other site 1160717010626 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1160717010627 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1160717010628 CysD dimerization site [polypeptide binding]; other site 1160717010629 G1 box; other site 1160717010630 putative GEF interaction site [polypeptide binding]; other site 1160717010631 GTP/Mg2+ binding site [chemical binding]; other site 1160717010632 Switch I region; other site 1160717010633 G2 box; other site 1160717010634 G3 box; other site 1160717010635 Switch II region; other site 1160717010636 G4 box; other site 1160717010637 G5 box; other site 1160717010638 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1160717010639 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1160717010640 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1160717010641 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1160717010642 Active Sites [active] 1160717010643 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1160717010644 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1160717010645 metal binding site [ion binding]; metal-binding site 1160717010646 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1160717010647 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1160717010648 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1160717010649 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1160717010650 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1160717010651 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1160717010652 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1160717010653 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1160717010654 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1160717010655 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1160717010656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1160717010657 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 1160717010658 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1160717010659 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1160717010660 Active Sites [active] 1160717010661 sulfite reductase subunit beta; Provisional; Region: PRK13504 1160717010662 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1160717010663 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1160717010664 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1160717010665 Flavodoxin; Region: Flavodoxin_1; pfam00258 1160717010666 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1160717010667 FAD binding pocket [chemical binding]; other site 1160717010668 FAD binding motif [chemical binding]; other site 1160717010669 catalytic residues [active] 1160717010670 NAD binding pocket [chemical binding]; other site 1160717010671 phosphate binding motif [ion binding]; other site 1160717010672 beta-alpha-beta structure motif; other site 1160717010673 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1160717010674 active site 1160717010675 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1160717010676 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1160717010677 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1160717010678 enolase; Provisional; Region: eno; PRK00077 1160717010679 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1160717010680 dimer interface [polypeptide binding]; other site 1160717010681 metal binding site [ion binding]; metal-binding site 1160717010682 substrate binding pocket [chemical binding]; other site 1160717010683 CTP synthetase; Validated; Region: pyrG; PRK05380 1160717010684 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1160717010685 Catalytic site [active] 1160717010686 active site 1160717010687 UTP binding site [chemical binding]; other site 1160717010688 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1160717010689 active site 1160717010690 putative oxyanion hole; other site 1160717010691 catalytic triad [active] 1160717010692 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1160717010693 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1160717010694 homodimer interface [polypeptide binding]; other site 1160717010695 metal binding site [ion binding]; metal-binding site 1160717010696 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1160717010697 homodimer interface [polypeptide binding]; other site 1160717010698 active site 1160717010699 putative chemical substrate binding site [chemical binding]; other site 1160717010700 metal binding site [ion binding]; metal-binding site 1160717010701 fimbrial protein SteA; Provisional; Region: PRK15261 1160717010702 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 1160717010703 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717010704 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717010705 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717010706 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 1160717010707 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717010708 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717010709 putative fimbrial protein SteD; Provisional; Region: PRK15275 1160717010710 putative fimbrial subunit SteE; Provisional; Region: PRK15276 1160717010711 genomic island 1160717010712 fimbrial protein SteF; Provisional; Region: PRK15260 1160717010713 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1160717010714 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1160717010715 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1160717010716 HD domain; Region: HD_4; pfam13328 1160717010717 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1160717010718 synthetase active site [active] 1160717010719 NTP binding site [chemical binding]; other site 1160717010720 metal binding site [ion binding]; metal-binding site 1160717010721 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1160717010722 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1160717010723 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1160717010724 TRAM domain; Region: TRAM; pfam01938 1160717010725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717010726 S-adenosylmethionine binding site [chemical binding]; other site 1160717010727 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1160717010728 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1160717010729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717010730 dimerization interface [polypeptide binding]; other site 1160717010731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717010732 dimer interface [polypeptide binding]; other site 1160717010733 phosphorylation site [posttranslational modification] 1160717010734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717010735 ATP binding site [chemical binding]; other site 1160717010736 Mg2+ binding site [ion binding]; other site 1160717010737 G-X-G motif; other site 1160717010738 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1160717010739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717010740 active site 1160717010741 phosphorylation site [posttranslational modification] 1160717010742 intermolecular recognition site; other site 1160717010743 dimerization interface [polypeptide binding]; other site 1160717010744 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1160717010745 putative binding surface; other site 1160717010746 active site 1160717010747 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1160717010748 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1160717010749 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1160717010750 active site 1160717010751 tetramer interface [polypeptide binding]; other site 1160717010752 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1160717010753 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1160717010754 active site 1160717010755 tetramer interface [polypeptide binding]; other site 1160717010756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010757 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717010758 putative substrate translocation pore; other site 1160717010759 flavodoxin; Provisional; Region: PRK08105 1160717010760 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1160717010761 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1160717010762 probable active site [active] 1160717010763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1160717010764 SecY interacting protein Syd; Provisional; Region: PRK04968 1160717010765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1160717010766 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1160717010767 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1160717010768 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1160717010769 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1160717010770 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1160717010771 serine transporter; Region: stp; TIGR00814 1160717010772 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1160717010773 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1160717010774 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1160717010775 flap endonuclease-like protein; Provisional; Region: PRK09482 1160717010776 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1160717010777 active site 1160717010778 metal binding site 1 [ion binding]; metal-binding site 1160717010779 putative 5' ssDNA interaction site; other site 1160717010780 metal binding site 3; metal-binding site 1160717010781 metal binding site 2 [ion binding]; metal-binding site 1160717010782 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1160717010783 putative DNA binding site [nucleotide binding]; other site 1160717010784 putative metal binding site [ion binding]; other site 1160717010785 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1160717010786 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1160717010787 dimer interface [polypeptide binding]; other site 1160717010788 active site 1160717010789 metal binding site [ion binding]; metal-binding site 1160717010790 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1160717010791 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1160717010792 intersubunit interface [polypeptide binding]; other site 1160717010793 active site 1160717010794 Zn2+ binding site [ion binding]; other site 1160717010795 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1160717010796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010797 putative substrate translocation pore; other site 1160717010798 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1160717010799 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1160717010800 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1160717010801 trimer interface [polypeptide binding]; other site 1160717010802 substrate binding site [chemical binding]; other site 1160717010803 Mn binding site [ion binding]; other site 1160717010804 L-fuculokinase; Provisional; Region: PRK10331 1160717010805 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1160717010806 nucleotide binding site [chemical binding]; other site 1160717010807 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1160717010808 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1160717010809 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1160717010810 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717010811 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1160717010812 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1160717010813 hypothetical protein; Provisional; Region: PRK10873 1160717010814 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1160717010815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717010816 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1160717010817 dimerization interface [polypeptide binding]; other site 1160717010818 substrate binding pocket [chemical binding]; other site 1160717010819 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1160717010820 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1160717010821 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1160717010822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717010823 catalytic residue [active] 1160717010824 CsdA-binding activator; Provisional; Region: PRK15019 1160717010825 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1160717010826 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1160717010827 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1160717010828 putative ATP binding site [chemical binding]; other site 1160717010829 putative substrate interface [chemical binding]; other site 1160717010830 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1160717010831 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1160717010832 MltA specific insert domain; Region: MltA; pfam03562 1160717010833 3D domain; Region: 3D; pfam06725 1160717010834 AMIN domain; Region: AMIN; pfam11741 1160717010835 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1160717010836 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1160717010837 active site 1160717010838 metal binding site [ion binding]; metal-binding site 1160717010839 N-acetylglutamate synthase; Validated; Region: PRK05279 1160717010840 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1160717010841 putative feedback inhibition sensing region; other site 1160717010842 putative nucleotide binding site [chemical binding]; other site 1160717010843 putative substrate binding site [chemical binding]; other site 1160717010844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717010845 Coenzyme A binding pocket [chemical binding]; other site 1160717010846 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1160717010847 AAA domain; Region: AAA_30; pfam13604 1160717010848 Family description; Region: UvrD_C_2; pfam13538 1160717010849 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1160717010850 protease3; Provisional; Region: PRK15101 1160717010851 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1160717010852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1160717010853 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1160717010854 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1160717010855 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1160717010856 hypothetical protein; Provisional; Region: PRK10332 1160717010857 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1160717010858 hypothetical protein; Provisional; Region: PRK11521 1160717010859 hypothetical protein; Provisional; Region: PRK10557 1160717010860 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1160717010861 hypothetical protein; Provisional; Region: PRK10506 1160717010862 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1160717010863 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1160717010864 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1160717010865 dimerization interface [polypeptide binding]; other site 1160717010866 active site 1160717010867 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1160717010868 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1160717010869 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1160717010870 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1160717010871 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1160717010872 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1160717010873 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1160717010874 putative active site [active] 1160717010875 Ap4A binding site [chemical binding]; other site 1160717010876 nudix motif; other site 1160717010877 putative metal binding site [ion binding]; other site 1160717010878 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1160717010879 putative DNA-binding cleft [nucleotide binding]; other site 1160717010880 putative DNA clevage site; other site 1160717010881 molecular lever; other site 1160717010882 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1160717010883 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1160717010884 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717010885 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717010886 active site 1160717010887 catalytic tetrad [active] 1160717010888 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1160717010889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010890 putative substrate translocation pore; other site 1160717010891 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1160717010892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1160717010893 putative acyl-acceptor binding pocket; other site 1160717010894 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1160717010895 acyl-activating enzyme (AAE) consensus motif; other site 1160717010896 putative AMP binding site [chemical binding]; other site 1160717010897 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1160717010898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717010899 DNA binding site [nucleotide binding] 1160717010900 domain linker motif; other site 1160717010901 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1160717010902 dimerization interface (closed form) [polypeptide binding]; other site 1160717010903 ligand binding site [chemical binding]; other site 1160717010904 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1160717010905 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717010906 DNA binding site [nucleotide binding] 1160717010907 domain linker motif; other site 1160717010908 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1160717010909 dimerization interface (closed form) [polypeptide binding]; other site 1160717010910 ligand binding site [chemical binding]; other site 1160717010911 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1160717010912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1160717010913 active site 1160717010914 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717010915 substrate binding site [chemical binding]; other site 1160717010916 catalytic residues [active] 1160717010917 dimer interface [polypeptide binding]; other site 1160717010918 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1160717010919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717010920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717010921 dimerization interface [polypeptide binding]; other site 1160717010922 putative racemase; Provisional; Region: PRK10200 1160717010923 aspartate racemase; Region: asp_race; TIGR00035 1160717010924 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1160717010925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010926 putative substrate translocation pore; other site 1160717010927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717010928 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1160717010929 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1160717010930 NADP binding site [chemical binding]; other site 1160717010931 homodimer interface [polypeptide binding]; other site 1160717010932 active site 1160717010933 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1160717010934 putative acyltransferase; Provisional; Region: PRK05790 1160717010935 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1160717010936 dimer interface [polypeptide binding]; other site 1160717010937 active site 1160717010938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717010939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717010940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1160717010941 dimerization interface [polypeptide binding]; other site 1160717010942 Predicted membrane protein [Function unknown]; Region: COG4125 1160717010943 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1160717010944 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1160717010945 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1160717010946 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1160717010947 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1160717010948 putative metal binding site [ion binding]; other site 1160717010949 putative homodimer interface [polypeptide binding]; other site 1160717010950 putative homotetramer interface [polypeptide binding]; other site 1160717010951 putative homodimer-homodimer interface [polypeptide binding]; other site 1160717010952 putative allosteric switch controlling residues; other site 1160717010953 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1160717010954 transcriptional activator SprB; Provisional; Region: PRK15320 1160717010955 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 1160717010956 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1160717010957 Fimbrial protein; Region: Fimbrial; pfam00419 1160717010958 genomic island 1160717010959 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1160717010960 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717010961 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717010962 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1160717010963 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717010964 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717010965 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717010966 fimbrial protein StdA; Provisional; Region: PRK15210 1160717010967 hypothetical protein; Provisional; Region: PRK10316 1160717010968 YfdX protein; Region: YfdX; pfam10938 1160717010969 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1160717010970 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1160717010971 tetramer interface [polypeptide binding]; other site 1160717010972 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1160717010973 active site 1160717010974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1160717010975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1160717010976 NAD(P) binding site [chemical binding]; other site 1160717010977 active site 1160717010978 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1160717010979 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1160717010980 substrate binding site [chemical binding]; other site 1160717010981 hexamer interface [polypeptide binding]; other site 1160717010982 metal binding site [ion binding]; metal-binding site 1160717010983 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1160717010984 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1160717010985 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1160717010986 active site 1160717010987 P-loop; other site 1160717010988 phosphorylation site [posttranslational modification] 1160717010989 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717010990 active site 1160717010991 phosphorylation site [posttranslational modification] 1160717010992 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717010993 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717010994 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717010995 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1160717010996 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1160717010997 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1160717010998 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1160717010999 active site 1160717011000 P-loop; other site 1160717011001 phosphorylation site [posttranslational modification] 1160717011002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717011003 active site 1160717011004 phosphorylation site [posttranslational modification] 1160717011005 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1160717011006 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1160717011007 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1160717011008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1160717011009 putative DNA binding site [nucleotide binding]; other site 1160717011010 putative Zn2+ binding site [ion binding]; other site 1160717011011 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1160717011012 active site 1160717011013 Int/Topo IB signature motif; other site 1160717011014 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1160717011015 Peptidase family M23; Region: Peptidase_M23; pfam01551 1160717011016 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1160717011017 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1160717011018 active site 1160717011019 metal binding site [ion binding]; metal-binding site 1160717011020 nudix motif; other site 1160717011021 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1160717011022 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1160717011023 dimer interface [polypeptide binding]; other site 1160717011024 putative anticodon binding site; other site 1160717011025 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1160717011026 motif 1; other site 1160717011027 active site 1160717011028 motif 2; other site 1160717011029 motif 3; other site 1160717011030 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1160717011031 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1160717011032 RF-1 domain; Region: RF-1; pfam00472 1160717011033 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1160717011034 DHH family; Region: DHH; pfam01368 1160717011035 DHHA1 domain; Region: DHHA1; pfam02272 1160717011036 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1160717011037 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1160717011038 dimerization domain [polypeptide binding]; other site 1160717011039 dimer interface [polypeptide binding]; other site 1160717011040 catalytic residues [active] 1160717011041 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1160717011042 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1160717011043 active site 1160717011044 Int/Topo IB signature motif; other site 1160717011045 flavodoxin FldB; Provisional; Region: PRK12359 1160717011046 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1160717011047 hypothetical protein; Provisional; Region: PRK10878 1160717011048 putative global regulator; Reviewed; Region: PRK09559 1160717011049 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1160717011050 hemolysin; Provisional; Region: PRK15087 1160717011051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1160717011052 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1160717011053 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1160717011054 beta-galactosidase; Region: BGL; TIGR03356 1160717011055 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1160717011056 glycine dehydrogenase; Provisional; Region: PRK05367 1160717011057 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1160717011058 tetramer interface [polypeptide binding]; other site 1160717011059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717011060 catalytic residue [active] 1160717011061 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1160717011062 tetramer interface [polypeptide binding]; other site 1160717011063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717011064 catalytic residue [active] 1160717011065 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1160717011066 lipoyl attachment site [posttranslational modification]; other site 1160717011067 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1160717011068 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1160717011069 oxidoreductase; Provisional; Region: PRK08013 1160717011070 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1160717011071 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1160717011072 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1160717011073 proline aminopeptidase P II; Provisional; Region: PRK10879 1160717011074 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1160717011075 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1160717011076 active site 1160717011077 hypothetical protein; Reviewed; Region: PRK01736 1160717011078 Cell division protein ZapA; Region: ZapA; cl01146 1160717011079 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1160717011080 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1160717011081 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1160717011082 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1160717011083 ligand binding site [chemical binding]; other site 1160717011084 NAD binding site [chemical binding]; other site 1160717011085 tetramer interface [polypeptide binding]; other site 1160717011086 catalytic site [active] 1160717011087 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1160717011088 L-serine binding site [chemical binding]; other site 1160717011089 ACT domain interface; other site 1160717011090 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1160717011091 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1160717011092 active site 1160717011093 dimer interface [polypeptide binding]; other site 1160717011094 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1160717011095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717011096 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1160717011097 putative dimerization interface [polypeptide binding]; other site 1160717011098 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1160717011099 oxidative stress defense protein; Provisional; Region: PRK11087 1160717011100 arginine exporter protein; Provisional; Region: PRK09304 1160717011101 mechanosensitive channel MscS; Provisional; Region: PRK10334 1160717011102 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1160717011103 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1160717011104 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1160717011105 active site 1160717011106 intersubunit interface [polypeptide binding]; other site 1160717011107 zinc binding site [ion binding]; other site 1160717011108 Na+ binding site [ion binding]; other site 1160717011109 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1160717011110 Phosphoglycerate kinase; Region: PGK; pfam00162 1160717011111 substrate binding site [chemical binding]; other site 1160717011112 hinge regions; other site 1160717011113 ADP binding site [chemical binding]; other site 1160717011114 catalytic site [active] 1160717011115 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1160717011116 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1160717011117 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1160717011118 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1160717011119 trimer interface [polypeptide binding]; other site 1160717011120 putative Zn binding site [ion binding]; other site 1160717011121 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1160717011122 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1160717011123 Walker A/P-loop; other site 1160717011124 ATP binding site [chemical binding]; other site 1160717011125 ABC transporter; Region: ABC_tran; pfam00005 1160717011126 Q-loop/lid; other site 1160717011127 ABC transporter signature motif; other site 1160717011128 Walker B; other site 1160717011129 D-loop; other site 1160717011130 H-loop/switch region; other site 1160717011131 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1160717011132 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1160717011133 Walker A/P-loop; other site 1160717011134 ATP binding site [chemical binding]; other site 1160717011135 Q-loop/lid; other site 1160717011136 ABC transporter signature motif; other site 1160717011137 Walker B; other site 1160717011138 D-loop; other site 1160717011139 H-loop/switch region; other site 1160717011140 transketolase; Reviewed; Region: PRK12753 1160717011141 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1160717011142 TPP-binding site [chemical binding]; other site 1160717011143 dimer interface [polypeptide binding]; other site 1160717011144 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1160717011145 PYR/PP interface [polypeptide binding]; other site 1160717011146 dimer interface [polypeptide binding]; other site 1160717011147 TPP binding site [chemical binding]; other site 1160717011148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1160717011149 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1160717011150 agmatinase; Region: agmatinase; TIGR01230 1160717011151 oligomer interface [polypeptide binding]; other site 1160717011152 putative active site [active] 1160717011153 Mn binding site [ion binding]; other site 1160717011154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1160717011155 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1160717011156 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1160717011157 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1160717011158 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1160717011159 putative NAD(P) binding site [chemical binding]; other site 1160717011160 catalytic Zn binding site [ion binding]; other site 1160717011161 structural Zn binding site [ion binding]; other site 1160717011162 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1160717011163 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1160717011164 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1160717011165 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1160717011166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717011167 DNA-binding site [nucleotide binding]; DNA binding site 1160717011168 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1160717011169 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1160717011170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1160717011171 dimer interface [polypeptide binding]; other site 1160717011172 active site 1160717011173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717011174 catalytic residues [active] 1160717011175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1160717011176 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1160717011177 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1160717011178 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1160717011179 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1160717011180 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1160717011181 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1160717011182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717011183 putative substrate translocation pore; other site 1160717011184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717011185 hypothetical protein; Provisional; Region: PRK04860 1160717011186 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1160717011187 DNA-specific endonuclease I; Provisional; Region: PRK15137 1160717011188 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1160717011189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1160717011190 RNA methyltransferase, RsmE family; Region: TIGR00046 1160717011191 glutathione synthetase; Provisional; Region: PRK05246 1160717011192 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1160717011193 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1160717011194 hypothetical protein; Validated; Region: PRK00228 1160717011195 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1160717011196 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1160717011197 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1160717011198 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1160717011199 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1160717011200 Walker A motif; other site 1160717011201 ATP binding site [chemical binding]; other site 1160717011202 Walker B motif; other site 1160717011203 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1160717011204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1160717011205 catalytic residue [active] 1160717011206 YGGT family; Region: YGGT; pfam02325 1160717011207 YGGT family; Region: YGGT; pfam02325 1160717011208 hypothetical protein; Validated; Region: PRK05090 1160717011209 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1160717011210 active site 1160717011211 dimerization interface [polypeptide binding]; other site 1160717011212 HemN family oxidoreductase; Provisional; Region: PRK05660 1160717011213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717011214 FeS/SAM binding site; other site 1160717011215 HemN C-terminal domain; Region: HemN_C; pfam06969 1160717011216 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1160717011217 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1160717011218 homodimer interface [polypeptide binding]; other site 1160717011219 active site 1160717011220 hypothetical protein; Provisional; Region: PRK10626 1160717011221 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1160717011222 hypothetical protein; Provisional; Region: PRK11702 1160717011223 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1160717011224 adenine DNA glycosylase; Provisional; Region: PRK10880 1160717011225 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1160717011226 minor groove reading motif; other site 1160717011227 helix-hairpin-helix signature motif; other site 1160717011228 substrate binding pocket [chemical binding]; other site 1160717011229 active site 1160717011230 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1160717011231 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1160717011232 DNA binding and oxoG recognition site [nucleotide binding] 1160717011233 oxidative damage protection protein; Provisional; Region: PRK05408 1160717011234 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1160717011235 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1160717011236 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717011237 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717011238 catalytic residue [active] 1160717011239 nucleoside transporter; Region: 2A0110; TIGR00889 1160717011240 ornithine decarboxylase; Provisional; Region: PRK13578 1160717011241 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1160717011242 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1160717011243 homodimer interface [polypeptide binding]; other site 1160717011244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717011245 catalytic residue [active] 1160717011246 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1160717011247 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1160717011248 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1160717011249 dimer interface [polypeptide binding]; other site 1160717011250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1160717011251 metal binding site [ion binding]; metal-binding site 1160717011252 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1160717011253 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1160717011254 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1160717011255 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1160717011256 putative active site [active] 1160717011257 putative catalytic site [active] 1160717011258 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1160717011259 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1160717011260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717011261 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1160717011262 putative dimerization interface [polypeptide binding]; other site 1160717011263 putative substrate binding pocket [chemical binding]; other site 1160717011264 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1160717011265 Sulfatase; Region: Sulfatase; pfam00884 1160717011266 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1160717011267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717011268 FeS/SAM binding site; other site 1160717011269 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1160717011270 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1160717011271 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717011272 DNA binding residues [nucleotide binding] 1160717011273 dimerization interface [polypeptide binding]; other site 1160717011274 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1160717011275 Amino acid permease; Region: AA_permease_2; pfam13520 1160717011276 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1160717011277 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1160717011278 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1160717011279 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1160717011280 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1160717011281 NAD(P) binding site [chemical binding]; other site 1160717011282 catalytic residues [active] 1160717011283 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1160717011284 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1160717011285 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1160717011286 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1160717011287 tetramer interface [polypeptide binding]; other site 1160717011288 active site 1160717011289 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1160717011290 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1160717011291 putative active site [active] 1160717011292 catalytic triad [active] 1160717011293 putative dimer interface [polypeptide binding]; other site 1160717011294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717011295 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717011296 putative substrate translocation pore; other site 1160717011297 mannonate dehydratase; Provisional; Region: PRK03906 1160717011298 mannonate dehydratase; Region: uxuA; TIGR00695 1160717011299 Glucuronate isomerase; Region: UxaC; pfam02614 1160717011300 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1160717011301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717011302 dimer interface [polypeptide binding]; other site 1160717011303 putative CheW interface [polypeptide binding]; other site 1160717011304 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1160717011305 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1160717011306 CHAP domain; Region: CHAP; pfam05257 1160717011307 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1160717011308 putative S-transferase; Provisional; Region: PRK11752 1160717011309 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1160717011310 C-terminal domain interface [polypeptide binding]; other site 1160717011311 GSH binding site (G-site) [chemical binding]; other site 1160717011312 dimer interface [polypeptide binding]; other site 1160717011313 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1160717011314 dimer interface [polypeptide binding]; other site 1160717011315 N-terminal domain interface [polypeptide binding]; other site 1160717011316 active site 1160717011317 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1160717011318 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1160717011319 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1160717011320 putative ligand binding residues [chemical binding]; other site 1160717011321 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1160717011322 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1160717011323 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1160717011324 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1160717011325 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1160717011326 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1160717011327 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1160717011328 putative substrate-binding site; other site 1160717011329 nickel binding site [ion binding]; other site 1160717011330 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1160717011331 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1160717011332 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1160717011333 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1160717011334 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1160717011335 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1160717011336 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1160717011337 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1160717011338 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1160717011339 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1160717011340 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1160717011341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717011342 dimerization interface [polypeptide binding]; other site 1160717011343 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717011344 dimer interface [polypeptide binding]; other site 1160717011345 putative CheW interface [polypeptide binding]; other site 1160717011346 hypothetical protein; Provisional; Region: PRK05208 1160717011347 oxidoreductase; Provisional; Region: PRK07985 1160717011348 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1160717011349 NAD binding site [chemical binding]; other site 1160717011350 metal binding site [ion binding]; metal-binding site 1160717011351 active site 1160717011352 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1160717011353 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1160717011354 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1160717011355 cystathionine beta-lyase; Provisional; Region: PRK08114 1160717011356 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1160717011357 homodimer interface [polypeptide binding]; other site 1160717011358 substrate-cofactor binding pocket; other site 1160717011359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717011360 catalytic residue [active] 1160717011361 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1160717011362 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1160717011363 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1160717011364 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1160717011365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717011366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717011367 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1160717011368 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1160717011369 dimer interface [polypeptide binding]; other site 1160717011370 active site 1160717011371 metal binding site [ion binding]; metal-binding site 1160717011372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1160717011373 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1160717011374 active site 1160717011375 catalytic tetrad [active] 1160717011376 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1160717011377 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1160717011378 transmembrane helices; other site 1160717011379 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1160717011380 nucleotide binding site/active site [active] 1160717011381 catalytic residue [active] 1160717011382 hypothetical protein; Provisional; Region: PRK01254 1160717011383 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1160717011384 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1160717011385 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1160717011386 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1160717011387 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1160717011388 DctM-like transporters; Region: DctM; pfam06808 1160717011389 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1160717011390 FtsI repressor; Provisional; Region: PRK10883 1160717011391 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1160717011392 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1160717011393 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1160717011394 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1160717011395 putative acyl-acceptor binding pocket; other site 1160717011396 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1160717011397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1160717011398 CAP-like domain; other site 1160717011399 active site 1160717011400 primary dimer interface [polypeptide binding]; other site 1160717011401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1160717011402 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717011403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717011404 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1160717011405 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1160717011406 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1160717011407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717011408 active site 1160717011409 phosphorylation site [posttranslational modification] 1160717011410 intermolecular recognition site; other site 1160717011411 dimerization interface [polypeptide binding]; other site 1160717011412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717011413 DNA binding site [nucleotide binding] 1160717011414 sensor protein QseC; Provisional; Region: PRK10337 1160717011415 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1160717011416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717011417 dimer interface [polypeptide binding]; other site 1160717011418 phosphorylation site [posttranslational modification] 1160717011419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717011420 ATP binding site [chemical binding]; other site 1160717011421 Mg2+ binding site [ion binding]; other site 1160717011422 G-X-G motif; other site 1160717011423 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1160717011424 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1160717011425 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1160717011426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717011427 ATP binding site [chemical binding]; other site 1160717011428 Mg2+ binding site [ion binding]; other site 1160717011429 G-X-G motif; other site 1160717011430 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1160717011431 anchoring element; other site 1160717011432 dimer interface [polypeptide binding]; other site 1160717011433 ATP binding site [chemical binding]; other site 1160717011434 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1160717011435 active site 1160717011436 metal binding site [ion binding]; metal-binding site 1160717011437 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1160717011438 esterase YqiA; Provisional; Region: PRK11071 1160717011439 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1160717011440 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1160717011441 active site 1160717011442 metal binding site [ion binding]; metal-binding site 1160717011443 hexamer interface [polypeptide binding]; other site 1160717011444 putative dehydrogenase; Provisional; Region: PRK11039 1160717011445 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1160717011446 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1160717011447 dimer interface [polypeptide binding]; other site 1160717011448 ADP-ribose binding site [chemical binding]; other site 1160717011449 active site 1160717011450 nudix motif; other site 1160717011451 metal binding site [ion binding]; metal-binding site 1160717011452 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1160717011453 hypothetical protein; Provisional; Region: PRK11653 1160717011454 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1160717011455 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1160717011456 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1160717011457 putative active site [active] 1160717011458 metal binding site [ion binding]; metal-binding site 1160717011459 zinc transporter ZupT; Provisional; Region: PRK04201 1160717011460 ZIP Zinc transporter; Region: Zip; pfam02535 1160717011461 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1160717011462 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1160717011463 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1160717011464 catalytic residues [active] 1160717011465 hinge region; other site 1160717011466 alpha helical domain; other site 1160717011467 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1160717011468 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1160717011469 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1160717011470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1160717011471 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1160717011472 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1160717011473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1160717011474 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1160717011475 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1160717011476 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1160717011477 putative ribose interaction site [chemical binding]; other site 1160717011478 putative ADP binding site [chemical binding]; other site 1160717011479 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1160717011480 active site 1160717011481 nucleotide binding site [chemical binding]; other site 1160717011482 HIGH motif; other site 1160717011483 KMSKS motif; other site 1160717011484 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1160717011485 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1160717011486 metal binding triad; other site 1160717011487 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1160717011488 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1160717011489 metal binding triad; other site 1160717011490 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1160717011491 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1160717011492 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1160717011493 putative active site [active] 1160717011494 putative metal binding residues [ion binding]; other site 1160717011495 signature motif; other site 1160717011496 putative triphosphate binding site [ion binding]; other site 1160717011497 CHAD domain; Region: CHAD; cl10506 1160717011498 SH3 domain-containing protein; Provisional; Region: PRK10884 1160717011499 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1160717011500 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1160717011501 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1160717011502 active site 1160717011503 NTP binding site [chemical binding]; other site 1160717011504 metal binding triad [ion binding]; metal-binding site 1160717011505 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1160717011506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1160717011507 Zn2+ binding site [ion binding]; other site 1160717011508 Mg2+ binding site [ion binding]; other site 1160717011509 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1160717011510 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1160717011511 homooctamer interface [polypeptide binding]; other site 1160717011512 active site 1160717011513 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1160717011514 UGMP family protein; Validated; Region: PRK09604 1160717011515 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1160717011516 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1160717011517 DNA primase; Validated; Region: dnaG; PRK05667 1160717011518 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1160717011519 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1160717011520 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1160717011521 active site 1160717011522 metal binding site [ion binding]; metal-binding site 1160717011523 interdomain interaction site; other site 1160717011524 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1160717011525 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1160717011526 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1160717011527 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1160717011528 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1160717011529 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1160717011530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1160717011531 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1160717011532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1160717011533 DNA binding residues [nucleotide binding] 1160717011534 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1160717011535 active site 1160717011536 SUMO-1 interface [polypeptide binding]; other site 1160717011537 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1160717011538 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1160717011539 FAD binding pocket [chemical binding]; other site 1160717011540 FAD binding motif [chemical binding]; other site 1160717011541 phosphate binding motif [ion binding]; other site 1160717011542 NAD binding pocket [chemical binding]; other site 1160717011543 Predicted transcriptional regulators [Transcription]; Region: COG1695 1160717011544 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1160717011545 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1160717011546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717011547 dimerization interface [polypeptide binding]; other site 1160717011548 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1160717011549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717011550 dimer interface [polypeptide binding]; other site 1160717011551 putative CheW interface [polypeptide binding]; other site 1160717011552 PAS fold; Region: PAS_3; pfam08447 1160717011553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1160717011554 putative active site [active] 1160717011555 heme pocket [chemical binding]; other site 1160717011556 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1160717011557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717011558 dimer interface [polypeptide binding]; other site 1160717011559 putative CheW interface [polypeptide binding]; other site 1160717011560 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1160717011561 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1160717011562 inhibitor-cofactor binding pocket; inhibition site 1160717011563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717011564 catalytic residue [active] 1160717011565 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1160717011566 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1160717011567 active site 1160717011568 FMN binding site [chemical binding]; other site 1160717011569 2,4-decadienoyl-CoA binding site; other site 1160717011570 catalytic residue [active] 1160717011571 4Fe-4S cluster binding site [ion binding]; other site 1160717011572 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1160717011573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717011574 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1160717011575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717011576 S-adenosylmethionine binding site [chemical binding]; other site 1160717011577 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1160717011578 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1160717011579 putative active site [active] 1160717011580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1160717011581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1160717011582 sraF-yybP-ykoY leader; SU5_nc131 1160717011583 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1160717011584 serine/threonine transporter SstT; Provisional; Region: PRK13628 1160717011585 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1160717011586 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1160717011587 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1160717011588 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1160717011589 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1160717011590 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1160717011591 Predicted membrane protein [Function unknown]; Region: COG5393 1160717011592 YqjK-like protein; Region: YqjK; pfam13997 1160717011593 Predicted membrane protein [Function unknown]; Region: COG2259 1160717011594 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1160717011595 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1160717011596 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1160717011597 putative dimer interface [polypeptide binding]; other site 1160717011598 N-terminal domain interface [polypeptide binding]; other site 1160717011599 putative substrate binding pocket (H-site) [chemical binding]; other site 1160717011600 Predicted membrane protein [Function unknown]; Region: COG3152 1160717011601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717011602 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1160717011603 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717011604 dimerization interface [polypeptide binding]; other site 1160717011605 Pirin-related protein [General function prediction only]; Region: COG1741 1160717011606 Pirin; Region: Pirin; pfam02678 1160717011607 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1160717011608 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1160717011609 serine transporter; Region: stp; TIGR00814 1160717011610 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1160717011611 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1160717011612 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1160717011613 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1160717011614 Pyruvate formate lyase 1; Region: PFL1; cd01678 1160717011615 coenzyme A binding site [chemical binding]; other site 1160717011616 active site 1160717011617 catalytic residues [active] 1160717011618 glycine loop; other site 1160717011619 propionate/acetate kinase; Provisional; Region: PRK12379 1160717011620 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1160717011621 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1160717011622 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1160717011623 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1160717011624 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1160717011625 tetramer interface [polypeptide binding]; other site 1160717011626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717011627 catalytic residue [active] 1160717011628 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1160717011629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717011630 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1160717011631 putative substrate binding pocket [chemical binding]; other site 1160717011632 putative dimerization interface [polypeptide binding]; other site 1160717011633 glycerate kinase I; Provisional; Region: PRK10342 1160717011634 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1160717011635 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1160717011636 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1160717011637 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1160717011638 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1160717011639 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1160717011640 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1160717011641 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1160717011642 intersubunit interface [polypeptide binding]; other site 1160717011643 active site 1160717011644 zinc binding site [ion binding]; other site 1160717011645 Na+ binding site [ion binding]; other site 1160717011646 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1160717011647 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717011648 active site 1160717011649 phosphorylation site [posttranslational modification] 1160717011650 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1160717011651 active site 1160717011652 P-loop; other site 1160717011653 phosphorylation site [posttranslational modification] 1160717011654 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1160717011655 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1160717011656 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1160717011657 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1160717011658 putative NAD(P) binding site [chemical binding]; other site 1160717011659 catalytic Zn binding site [ion binding]; other site 1160717011660 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717011661 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717011662 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717011663 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1160717011664 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1160717011665 putative SAM binding site [chemical binding]; other site 1160717011666 putative homodimer interface [polypeptide binding]; other site 1160717011667 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1160717011668 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1160717011669 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1160717011670 putative ligand binding site [chemical binding]; other site 1160717011671 TIGR00252 family protein; Region: TIGR00252 1160717011672 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1160717011673 dimer interface [polypeptide binding]; other site 1160717011674 active site 1160717011675 outer membrane lipoprotein; Provisional; Region: PRK11023 1160717011676 BON domain; Region: BON; pfam04972 1160717011677 BON domain; Region: BON; pfam04972 1160717011678 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1160717011679 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1160717011680 NAD binding site [chemical binding]; other site 1160717011681 active site 1160717011682 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1160717011683 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1160717011684 proposed catalytic triad [active] 1160717011685 conserved cys residue [active] 1160717011686 hypothetical protein; Provisional; Region: PRK03467 1160717011687 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1160717011688 GIY-YIG motif/motif A; other site 1160717011689 putative active site [active] 1160717011690 putative metal binding site [ion binding]; other site 1160717011691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1160717011692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717011693 Coenzyme A binding pocket [chemical binding]; other site 1160717011694 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1160717011695 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1160717011696 Peptidase family U32; Region: Peptidase_U32; pfam01136 1160717011697 putative protease; Provisional; Region: PRK15447 1160717011698 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1160717011699 hypothetical protein; Provisional; Region: PRK10508 1160717011700 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1160717011701 tryptophan permease; Provisional; Region: PRK10483 1160717011702 aromatic amino acid transport protein; Region: araaP; TIGR00837 1160717011703 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1160717011704 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1160717011705 ATP binding site [chemical binding]; other site 1160717011706 Mg++ binding site [ion binding]; other site 1160717011707 motif III; other site 1160717011708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717011709 nucleotide binding region [chemical binding]; other site 1160717011710 ATP-binding site [chemical binding]; other site 1160717011711 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1160717011712 putative RNA binding site [nucleotide binding]; other site 1160717011713 lipoprotein NlpI; Provisional; Region: PRK11189 1160717011714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1160717011715 binding surface 1160717011716 TPR motif; other site 1160717011717 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1160717011718 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1160717011719 RNase E interface [polypeptide binding]; other site 1160717011720 trimer interface [polypeptide binding]; other site 1160717011721 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1160717011722 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1160717011723 RNase E interface [polypeptide binding]; other site 1160717011724 trimer interface [polypeptide binding]; other site 1160717011725 active site 1160717011726 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1160717011727 putative nucleic acid binding region [nucleotide binding]; other site 1160717011728 G-X-X-G motif; other site 1160717011729 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1160717011730 RNA binding site [nucleotide binding]; other site 1160717011731 domain interface; other site 1160717011732 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1160717011733 16S/18S rRNA binding site [nucleotide binding]; other site 1160717011734 S13e-L30e interaction site [polypeptide binding]; other site 1160717011735 25S rRNA binding site [nucleotide binding]; other site 1160717011736 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1160717011737 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1160717011738 RNA binding site [nucleotide binding]; other site 1160717011739 active site 1160717011740 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1160717011741 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1160717011742 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1160717011743 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1160717011744 translation initiation factor IF-2; Region: IF-2; TIGR00487 1160717011745 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1160717011746 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1160717011747 G1 box; other site 1160717011748 putative GEF interaction site [polypeptide binding]; other site 1160717011749 GTP/Mg2+ binding site [chemical binding]; other site 1160717011750 Switch I region; other site 1160717011751 G2 box; other site 1160717011752 G3 box; other site 1160717011753 Switch II region; other site 1160717011754 G4 box; other site 1160717011755 G5 box; other site 1160717011756 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1160717011757 Translation-initiation factor 2; Region: IF-2; pfam11987 1160717011758 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1160717011759 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1160717011760 NusA N-terminal domain; Region: NusA_N; pfam08529 1160717011761 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1160717011762 RNA binding site [nucleotide binding]; other site 1160717011763 homodimer interface [polypeptide binding]; other site 1160717011764 NusA-like KH domain; Region: KH_5; pfam13184 1160717011765 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1160717011766 G-X-X-G motif; other site 1160717011767 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1160717011768 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1160717011769 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1160717011770 hypothetical protein; Provisional; Region: PRK14641 1160717011771 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1160717011772 putative oligomer interface [polypeptide binding]; other site 1160717011773 putative RNA binding site [nucleotide binding]; other site 1160717011774 argininosuccinate synthase; Validated; Region: PRK05370 1160717011775 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1160717011776 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1160717011777 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1160717011778 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1160717011779 active site 1160717011780 substrate binding site [chemical binding]; other site 1160717011781 metal binding site [ion binding]; metal-binding site 1160717011782 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1160717011783 dihydropteroate synthase; Region: DHPS; TIGR01496 1160717011784 substrate binding pocket [chemical binding]; other site 1160717011785 dimer interface [polypeptide binding]; other site 1160717011786 inhibitor binding site; inhibition site 1160717011787 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1160717011788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717011789 Walker A motif; other site 1160717011790 ATP binding site [chemical binding]; other site 1160717011791 Walker B motif; other site 1160717011792 arginine finger; other site 1160717011793 Peptidase family M41; Region: Peptidase_M41; pfam01434 1160717011794 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1160717011795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717011796 S-adenosylmethionine binding site [chemical binding]; other site 1160717011797 RNA-binding protein YhbY; Provisional; Region: PRK10343 1160717011798 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1160717011799 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1160717011800 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1160717011801 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1160717011802 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1160717011803 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1160717011804 GTP1/OBG; Region: GTP1_OBG; pfam01018 1160717011805 Obg GTPase; Region: Obg; cd01898 1160717011806 G1 box; other site 1160717011807 GTP/Mg2+ binding site [chemical binding]; other site 1160717011808 Switch I region; other site 1160717011809 G2 box; other site 1160717011810 G3 box; other site 1160717011811 Switch II region; other site 1160717011812 G4 box; other site 1160717011813 G5 box; other site 1160717011814 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1160717011815 EamA-like transporter family; Region: EamA; pfam00892 1160717011816 EamA-like transporter family; Region: EamA; pfam00892 1160717011817 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1160717011818 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1160717011819 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1160717011820 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1160717011821 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1160717011822 substrate binding pocket [chemical binding]; other site 1160717011823 chain length determination region; other site 1160717011824 substrate-Mg2+ binding site; other site 1160717011825 catalytic residues [active] 1160717011826 aspartate-rich region 1; other site 1160717011827 active site lid residues [active] 1160717011828 aspartate-rich region 2; other site 1160717011829 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1160717011830 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1160717011831 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1160717011832 hinge; other site 1160717011833 active site 1160717011834 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1160717011835 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1160717011836 anti sigma factor interaction site; other site 1160717011837 regulatory phosphorylation site [posttranslational modification]; other site 1160717011838 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1160717011839 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1160717011840 mce related protein; Region: MCE; pfam02470 1160717011841 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1160717011842 conserved hypothetical integral membrane protein; Region: TIGR00056 1160717011843 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1160717011844 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1160717011845 Walker A/P-loop; other site 1160717011846 ATP binding site [chemical binding]; other site 1160717011847 Q-loop/lid; other site 1160717011848 ABC transporter signature motif; other site 1160717011849 Walker B; other site 1160717011850 D-loop; other site 1160717011851 H-loop/switch region; other site 1160717011852 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1160717011853 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1160717011854 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1160717011855 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1160717011856 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1160717011857 putative active site [active] 1160717011858 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1160717011859 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1160717011860 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1160717011861 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1160717011862 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1160717011863 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1160717011864 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1160717011865 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1160717011866 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1160717011867 Walker A/P-loop; other site 1160717011868 ATP binding site [chemical binding]; other site 1160717011869 Q-loop/lid; other site 1160717011870 ABC transporter signature motif; other site 1160717011871 Walker B; other site 1160717011872 D-loop; other site 1160717011873 H-loop/switch region; other site 1160717011874 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1160717011875 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1160717011876 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1160717011877 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1160717011878 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1160717011879 30S subunit binding site; other site 1160717011880 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717011881 active site 1160717011882 phosphorylation site [posttranslational modification] 1160717011883 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1160717011884 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1160717011885 dimerization domain swap beta strand [polypeptide binding]; other site 1160717011886 regulatory protein interface [polypeptide binding]; other site 1160717011887 active site 1160717011888 regulatory phosphorylation site [posttranslational modification]; other site 1160717011889 hypothetical protein; Provisional; Region: PRK10345 1160717011890 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1160717011891 Transglycosylase; Region: Transgly; cl17702 1160717011892 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1160717011893 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1160717011894 conserved cys residue [active] 1160717011895 radical SAM protein, TIGR01212 family; Region: TIGR01212 1160717011896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1160717011897 FeS/SAM binding site; other site 1160717011898 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1160717011899 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1160717011900 active site 1160717011901 dimer interface [polypeptide binding]; other site 1160717011902 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1160717011903 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1160717011904 active site 1160717011905 FMN binding site [chemical binding]; other site 1160717011906 substrate binding site [chemical binding]; other site 1160717011907 3Fe-4S cluster binding site [ion binding]; other site 1160717011908 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1160717011909 domain interface; other site 1160717011910 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1160717011911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717011912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717011913 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1160717011914 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1160717011915 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1160717011916 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1160717011917 Na binding site [ion binding]; other site 1160717011918 putative substrate binding site [chemical binding]; other site 1160717011919 cytosine deaminase; Provisional; Region: PRK09230 1160717011920 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1160717011921 active site 1160717011922 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1160717011923 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1160717011924 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717011925 nucleotide binding site [chemical binding]; other site 1160717011926 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1160717011927 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1160717011928 putative active site cavity [active] 1160717011929 putative sialic acid transporter; Provisional; Region: PRK03893 1160717011930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717011931 putative substrate translocation pore; other site 1160717011932 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1160717011933 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1160717011934 inhibitor site; inhibition site 1160717011935 active site 1160717011936 dimer interface [polypeptide binding]; other site 1160717011937 catalytic residue [active] 1160717011938 transcriptional regulator NanR; Provisional; Region: PRK03837 1160717011939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717011940 DNA-binding site [nucleotide binding]; DNA binding site 1160717011941 FCD domain; Region: FCD; pfam07729 1160717011942 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1160717011943 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1160717011944 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1160717011945 C-terminal domain interface [polypeptide binding]; other site 1160717011946 putative GSH binding site (G-site) [chemical binding]; other site 1160717011947 dimer interface [polypeptide binding]; other site 1160717011948 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1160717011949 dimer interface [polypeptide binding]; other site 1160717011950 N-terminal domain interface [polypeptide binding]; other site 1160717011951 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1160717011952 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1160717011953 23S rRNA interface [nucleotide binding]; other site 1160717011954 L3 interface [polypeptide binding]; other site 1160717011955 Predicted ATPase [General function prediction only]; Region: COG1485 1160717011956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1160717011957 hypothetical protein; Provisional; Region: PRK11677 1160717011958 serine endoprotease; Provisional; Region: PRK10139 1160717011959 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1160717011960 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1160717011961 protein binding site [polypeptide binding]; other site 1160717011962 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1160717011963 serine endoprotease; Provisional; Region: PRK10898 1160717011964 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1160717011965 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1160717011966 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1160717011967 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1160717011968 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1160717011969 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1160717011970 active site 1160717011971 catalytic residues [active] 1160717011972 metal binding site [ion binding]; metal-binding site 1160717011973 homodimer binding site [polypeptide binding]; other site 1160717011974 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1160717011975 carboxyltransferase (CT) interaction site; other site 1160717011976 biotinylation site [posttranslational modification]; other site 1160717011977 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1160717011978 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1160717011979 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1160717011980 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1160717011981 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1160717011982 transmembrane helices; other site 1160717011983 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1160717011984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717011985 DNA-binding site [nucleotide binding]; DNA binding site 1160717011986 FCD domain; Region: FCD; pfam07729 1160717011987 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1160717011988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717011989 DNA-binding site [nucleotide binding]; DNA binding site 1160717011990 malate dehydrogenase; Provisional; Region: PRK05086 1160717011991 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1160717011992 NAD binding site [chemical binding]; other site 1160717011993 dimerization interface [polypeptide binding]; other site 1160717011994 Substrate binding site [chemical binding]; other site 1160717011995 arginine repressor; Provisional; Region: PRK05066 1160717011996 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1160717011997 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1160717011998 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717011999 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1160717012000 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1160717012001 RNAase interaction site [polypeptide binding]; other site 1160717012002 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1160717012003 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1160717012004 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1160717012005 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717012006 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717012007 efflux system membrane protein; Provisional; Region: PRK11594 1160717012008 transcriptional regulator; Provisional; Region: PRK10632 1160717012009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717012010 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1160717012011 putative effector binding pocket; other site 1160717012012 dimerization interface [polypeptide binding]; other site 1160717012013 protease TldD; Provisional; Region: tldD; PRK10735 1160717012014 hypothetical protein; Provisional; Region: PRK10899 1160717012015 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1160717012016 ribonuclease G; Provisional; Region: PRK11712 1160717012017 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1160717012018 homodimer interface [polypeptide binding]; other site 1160717012019 oligonucleotide binding site [chemical binding]; other site 1160717012020 Maf-like protein; Region: Maf; pfam02545 1160717012021 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1160717012022 active site 1160717012023 dimer interface [polypeptide binding]; other site 1160717012024 rod shape-determining protein MreD; Provisional; Region: PRK11060 1160717012025 rod shape-determining protein MreC; Region: mreC; TIGR00219 1160717012026 rod shape-determining protein MreC; Region: MreC; pfam04085 1160717012027 rod shape-determining protein MreB; Provisional; Region: PRK13927 1160717012028 MreB and similar proteins; Region: MreB_like; cd10225 1160717012029 nucleotide binding site [chemical binding]; other site 1160717012030 Mg binding site [ion binding]; other site 1160717012031 putative protofilament interaction site [polypeptide binding]; other site 1160717012032 RodZ interaction site [polypeptide binding]; other site 1160717012033 regulatory protein CsrD; Provisional; Region: PRK11059 1160717012034 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717012035 metal binding site [ion binding]; metal-binding site 1160717012036 active site 1160717012037 I-site; other site 1160717012038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717012039 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1160717012040 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1160717012041 NADP binding site [chemical binding]; other site 1160717012042 dimer interface [polypeptide binding]; other site 1160717012043 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1160717012044 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1160717012045 Moco binding site; other site 1160717012046 metal coordination site [ion binding]; other site 1160717012047 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1160717012048 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1160717012049 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1160717012050 carboxyltransferase (CT) interaction site; other site 1160717012051 biotinylation site [posttranslational modification]; other site 1160717012052 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1160717012053 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1160717012054 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1160717012055 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1160717012056 hypothetical protein; Provisional; Region: PRK10633 1160717012057 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1160717012058 Na binding site [ion binding]; other site 1160717012059 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1160717012060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1160717012061 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1160717012062 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1160717012063 FMN binding site [chemical binding]; other site 1160717012064 active site 1160717012065 catalytic residues [active] 1160717012066 substrate binding site [chemical binding]; other site 1160717012067 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1160717012068 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1160717012069 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1160717012070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717012071 DNA methylase; Region: N6_N4_Mtase; pfam01555 1160717012072 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1160717012073 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1160717012074 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1160717012075 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1160717012076 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717012077 metal binding site [ion binding]; metal-binding site 1160717012078 active site 1160717012079 I-site; other site 1160717012080 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717012081 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1160717012082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717012083 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1160717012084 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1160717012085 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717012086 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717012087 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1160717012088 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1160717012089 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1160717012090 trimer interface [polypeptide binding]; other site 1160717012091 putative metal binding site [ion binding]; other site 1160717012092 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1160717012093 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1160717012094 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1160717012095 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1160717012096 shikimate binding site; other site 1160717012097 NAD(P) binding site [chemical binding]; other site 1160717012098 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1160717012099 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1160717012100 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1160717012101 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1160717012102 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1160717012103 hypothetical protein; Validated; Region: PRK03430 1160717012104 hypothetical protein; Provisional; Region: PRK10736 1160717012105 DNA protecting protein DprA; Region: dprA; TIGR00732 1160717012106 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1160717012107 active site 1160717012108 catalytic residues [active] 1160717012109 metal binding site [ion binding]; metal-binding site 1160717012110 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1160717012111 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1160717012112 putative active site [active] 1160717012113 substrate binding site [chemical binding]; other site 1160717012114 putative cosubstrate binding site; other site 1160717012115 catalytic site [active] 1160717012116 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1160717012117 substrate binding site [chemical binding]; other site 1160717012118 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1160717012119 putative RNA binding site [nucleotide binding]; other site 1160717012120 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1160717012121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717012122 S-adenosylmethionine binding site [chemical binding]; other site 1160717012123 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1160717012124 TrkA-N domain; Region: TrkA_N; pfam02254 1160717012125 TrkA-C domain; Region: TrkA_C; pfam02080 1160717012126 TrkA-N domain; Region: TrkA_N; pfam02254 1160717012127 TrkA-C domain; Region: TrkA_C; pfam02080 1160717012128 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1160717012129 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1160717012130 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1160717012131 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1160717012132 DNA binding residues [nucleotide binding] 1160717012133 dimer interface [polypeptide binding]; other site 1160717012134 metal binding site [ion binding]; metal-binding site 1160717012135 hypothetical protein; Provisional; Region: PRK10203 1160717012136 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1160717012137 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1160717012138 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1160717012139 alphaNTD homodimer interface [polypeptide binding]; other site 1160717012140 alphaNTD - beta interaction site [polypeptide binding]; other site 1160717012141 alphaNTD - beta' interaction site [polypeptide binding]; other site 1160717012142 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1160717012143 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1160717012144 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1160717012145 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717012146 RNA binding surface [nucleotide binding]; other site 1160717012147 30S ribosomal protein S11; Validated; Region: PRK05309 1160717012148 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1160717012149 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1160717012150 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1160717012151 SecY translocase; Region: SecY; pfam00344 1160717012152 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1160717012153 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1160717012154 23S rRNA binding site [nucleotide binding]; other site 1160717012155 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1160717012156 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1160717012157 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1160717012158 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1160717012159 23S rRNA interface [nucleotide binding]; other site 1160717012160 5S rRNA interface [nucleotide binding]; other site 1160717012161 L27 interface [polypeptide binding]; other site 1160717012162 L5 interface [polypeptide binding]; other site 1160717012163 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1160717012164 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1160717012165 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1160717012166 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1160717012167 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1160717012168 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1160717012169 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1160717012170 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1160717012171 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1160717012172 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1160717012173 RNA binding site [nucleotide binding]; other site 1160717012174 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1160717012175 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1160717012176 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1160717012177 23S rRNA interface [nucleotide binding]; other site 1160717012178 putative translocon interaction site; other site 1160717012179 signal recognition particle (SRP54) interaction site; other site 1160717012180 L23 interface [polypeptide binding]; other site 1160717012181 trigger factor interaction site; other site 1160717012182 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1160717012183 23S rRNA interface [nucleotide binding]; other site 1160717012184 5S rRNA interface [nucleotide binding]; other site 1160717012185 putative antibiotic binding site [chemical binding]; other site 1160717012186 L25 interface [polypeptide binding]; other site 1160717012187 L27 interface [polypeptide binding]; other site 1160717012188 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1160717012189 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1160717012190 G-X-X-G motif; other site 1160717012191 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1160717012192 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1160717012193 protein-rRNA interface [nucleotide binding]; other site 1160717012194 putative translocon binding site; other site 1160717012195 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1160717012196 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1160717012197 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1160717012198 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1160717012199 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1160717012200 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1160717012201 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1160717012202 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1160717012203 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1160717012204 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1160717012205 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1160717012206 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1160717012207 heme binding site [chemical binding]; other site 1160717012208 ferroxidase pore; other site 1160717012209 ferroxidase diiron center [ion binding]; other site 1160717012210 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1160717012211 elongation factor Tu; Reviewed; Region: PRK00049 1160717012212 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1160717012213 G1 box; other site 1160717012214 GEF interaction site [polypeptide binding]; other site 1160717012215 GTP/Mg2+ binding site [chemical binding]; other site 1160717012216 Switch I region; other site 1160717012217 G2 box; other site 1160717012218 G3 box; other site 1160717012219 Switch II region; other site 1160717012220 G4 box; other site 1160717012221 G5 box; other site 1160717012222 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1160717012223 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1160717012224 Antibiotic Binding Site [chemical binding]; other site 1160717012225 elongation factor G; Reviewed; Region: PRK00007 1160717012226 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1160717012227 G1 box; other site 1160717012228 putative GEF interaction site [polypeptide binding]; other site 1160717012229 GTP/Mg2+ binding site [chemical binding]; other site 1160717012230 Switch I region; other site 1160717012231 G2 box; other site 1160717012232 G3 box; other site 1160717012233 Switch II region; other site 1160717012234 G4 box; other site 1160717012235 G5 box; other site 1160717012236 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1160717012237 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1160717012238 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1160717012239 30S ribosomal protein S7; Validated; Region: PRK05302 1160717012240 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1160717012241 S17 interaction site [polypeptide binding]; other site 1160717012242 S8 interaction site; other site 1160717012243 16S rRNA interaction site [nucleotide binding]; other site 1160717012244 streptomycin interaction site [chemical binding]; other site 1160717012245 23S rRNA interaction site [nucleotide binding]; other site 1160717012246 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1160717012247 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1160717012248 sulfur relay protein TusC; Validated; Region: PRK00211 1160717012249 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1160717012250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1160717012251 YheO-like PAS domain; Region: PAS_6; pfam08348 1160717012252 HTH domain; Region: HTH_22; pfam13309 1160717012253 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1160717012254 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1160717012255 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1160717012256 phi X174 lysis protein; Provisional; Region: PRK02793 1160717012257 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1160717012258 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1160717012259 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1160717012260 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1160717012261 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1160717012262 TrkA-N domain; Region: TrkA_N; pfam02254 1160717012263 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1160717012264 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1160717012265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717012266 Walker A/P-loop; other site 1160717012267 ATP binding site [chemical binding]; other site 1160717012268 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717012269 ABC transporter signature motif; other site 1160717012270 Walker B; other site 1160717012271 D-loop; other site 1160717012272 ABC transporter; Region: ABC_tran_2; pfam12848 1160717012273 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1160717012274 putative monooxygenase; Provisional; Region: PRK11118 1160717012275 putative hydrolase; Provisional; Region: PRK10985 1160717012276 hypothetical protein; Provisional; Region: PRK04966 1160717012277 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1160717012278 active site 1160717012279 hypothetical protein; Provisional; Region: PRK10738 1160717012280 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1160717012281 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1160717012282 ligand binding site [chemical binding]; other site 1160717012283 flexible hinge region; other site 1160717012284 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1160717012285 putative switch regulator; other site 1160717012286 non-specific DNA interactions [nucleotide binding]; other site 1160717012287 DNA binding site [nucleotide binding] 1160717012288 sequence specific DNA binding site [nucleotide binding]; other site 1160717012289 putative cAMP binding site [chemical binding]; other site 1160717012290 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1160717012291 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1160717012292 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1160717012293 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1160717012294 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1160717012295 inhibitor-cofactor binding pocket; inhibition site 1160717012296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717012297 catalytic residue [active] 1160717012298 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1160717012299 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1160717012300 glutamine binding [chemical binding]; other site 1160717012301 catalytic triad [active] 1160717012302 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1160717012303 cell filamentation protein Fic; Provisional; Region: PRK10347 1160717012304 hypothetical protein; Provisional; Region: PRK10204 1160717012305 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1160717012306 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1160717012307 substrate binding site [chemical binding]; other site 1160717012308 putative transporter; Provisional; Region: PRK03699 1160717012309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717012310 putative substrate translocation pore; other site 1160717012311 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1160717012312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717012313 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1160717012314 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1160717012315 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1160717012316 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1160717012317 nitrite transporter NirC; Provisional; Region: PRK11562 1160717012318 siroheme synthase; Provisional; Region: cysG; PRK10637 1160717012319 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1160717012320 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1160717012321 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1160717012322 active site 1160717012323 SAM binding site [chemical binding]; other site 1160717012324 homodimer interface [polypeptide binding]; other site 1160717012325 genomic island 1160717012326 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1160717012327 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1160717012328 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1160717012329 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1160717012330 active site 1160717012331 HIGH motif; other site 1160717012332 dimer interface [polypeptide binding]; other site 1160717012333 KMSKS motif; other site 1160717012334 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1160717012335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717012336 motif II; other site 1160717012337 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1160717012338 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1160717012339 substrate binding site [chemical binding]; other site 1160717012340 hexamer interface [polypeptide binding]; other site 1160717012341 metal binding site [ion binding]; metal-binding site 1160717012342 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1160717012343 cell division protein DamX; Validated; Region: PRK10905 1160717012344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1160717012345 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1160717012346 active site 1160717012347 dimer interface [polypeptide binding]; other site 1160717012348 metal binding site [ion binding]; metal-binding site 1160717012349 shikimate kinase; Reviewed; Region: aroK; PRK00131 1160717012350 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1160717012351 ADP binding site [chemical binding]; other site 1160717012352 magnesium binding site [ion binding]; other site 1160717012353 putative shikimate binding site; other site 1160717012354 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1160717012355 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1160717012356 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1160717012357 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1160717012358 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1160717012359 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1160717012360 Transglycosylase; Region: Transgly; pfam00912 1160717012361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1160717012362 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1160717012363 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1160717012364 ADP-ribose binding site [chemical binding]; other site 1160717012365 dimer interface [polypeptide binding]; other site 1160717012366 active site 1160717012367 nudix motif; other site 1160717012368 metal binding site [ion binding]; metal-binding site 1160717012369 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1160717012370 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1160717012371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717012372 motif II; other site 1160717012373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1160717012374 RNA binding surface [nucleotide binding]; other site 1160717012375 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1160717012376 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1160717012377 dimerization interface [polypeptide binding]; other site 1160717012378 domain crossover interface; other site 1160717012379 redox-dependent activation switch; other site 1160717012380 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1160717012381 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1160717012382 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1160717012383 active site 1160717012384 substrate-binding site [chemical binding]; other site 1160717012385 metal-binding site [ion binding] 1160717012386 ATP binding site [chemical binding]; other site 1160717012387 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1160717012388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717012389 dimerization interface [polypeptide binding]; other site 1160717012390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717012391 dimer interface [polypeptide binding]; other site 1160717012392 phosphorylation site [posttranslational modification] 1160717012393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717012394 ATP binding site [chemical binding]; other site 1160717012395 G-X-G motif; other site 1160717012396 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1160717012397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717012398 active site 1160717012399 phosphorylation site [posttranslational modification] 1160717012400 intermolecular recognition site; other site 1160717012401 dimerization interface [polypeptide binding]; other site 1160717012402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717012403 DNA binding site [nucleotide binding] 1160717012404 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1160717012405 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1160717012406 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1160717012407 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1160717012408 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1160717012409 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1160717012410 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1160717012411 RNA binding site [nucleotide binding]; other site 1160717012412 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1160717012413 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1160717012414 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1160717012415 G1 box; other site 1160717012416 GTP/Mg2+ binding site [chemical binding]; other site 1160717012417 Switch I region; other site 1160717012418 G2 box; other site 1160717012419 G3 box; other site 1160717012420 Switch II region; other site 1160717012421 G4 box; other site 1160717012422 G5 box; other site 1160717012423 Nucleoside recognition; Region: Gate; pfam07670 1160717012424 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1160717012425 Nucleoside recognition; Region: Gate; pfam07670 1160717012426 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1160717012427 hypothetical protein; Provisional; Region: PRK09956 1160717012428 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1160717012429 carboxylesterase BioH; Provisional; Region: PRK10349 1160717012430 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1160717012431 DNA utilization protein GntX; Provisional; Region: PRK11595 1160717012432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717012433 active site 1160717012434 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1160717012435 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1160717012436 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1160717012437 high-affinity gluconate transporter; Provisional; Region: PRK14984 1160717012438 gluconate transporter; Region: gntP; TIGR00791 1160717012439 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1160717012440 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1160717012441 maltodextrin phosphorylase; Provisional; Region: PRK14985 1160717012442 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1160717012443 homodimer interface [polypeptide binding]; other site 1160717012444 active site pocket [active] 1160717012445 transcriptional regulator MalT; Provisional; Region: PRK04841 1160717012446 AAA ATPase domain; Region: AAA_16; pfam13191 1160717012447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717012448 DNA binding residues [nucleotide binding] 1160717012449 dimerization interface [polypeptide binding]; other site 1160717012450 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1160717012451 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1160717012452 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1160717012453 putative active site [active] 1160717012454 adenylation catalytic residue [active] 1160717012455 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1160717012456 hypothetical protein; Reviewed; Region: PRK09588 1160717012457 TROVE domain; Region: TROVE; pfam05731 1160717012458 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1160717012459 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1160717012460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717012461 Walker A motif; other site 1160717012462 ATP binding site [chemical binding]; other site 1160717012463 Walker B motif; other site 1160717012464 arginine finger; other site 1160717012465 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1160717012466 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717012467 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1160717012468 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1160717012469 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1160717012470 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1160717012471 active site residue [active] 1160717012472 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1160717012473 hypothetical protein; Provisional; Region: PRK09781 1160717012474 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1160717012475 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1160717012476 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1160717012477 dimer interface [polypeptide binding]; other site 1160717012478 active site 1160717012479 metal binding site [ion binding]; metal-binding site 1160717012480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717012481 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717012482 putative substrate translocation pore; other site 1160717012483 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 1160717012484 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1160717012485 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1160717012486 inhibitor site; inhibition site 1160717012487 active site 1160717012488 dimer interface [polypeptide binding]; other site 1160717012489 catalytic residue [active] 1160717012490 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1160717012491 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1160717012492 Bacterial transcriptional regulator; Region: IclR; pfam01614 1160717012493 glycogen phosphorylase; Provisional; Region: PRK14986 1160717012494 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1160717012495 homodimer interface [polypeptide binding]; other site 1160717012496 active site pocket [active] 1160717012497 glycogen synthase; Provisional; Region: glgA; PRK00654 1160717012498 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1160717012499 ADP-binding pocket [chemical binding]; other site 1160717012500 homodimer interface [polypeptide binding]; other site 1160717012501 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1160717012502 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1160717012503 ligand binding site; other site 1160717012504 oligomer interface; other site 1160717012505 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1160717012506 dimer interface [polypeptide binding]; other site 1160717012507 N-terminal domain interface [polypeptide binding]; other site 1160717012508 sulfate 1 binding site; other site 1160717012509 glycogen debranching enzyme; Provisional; Region: PRK03705 1160717012510 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1160717012511 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1160717012512 active site 1160717012513 catalytic site [active] 1160717012514 glycogen branching enzyme; Provisional; Region: PRK05402 1160717012515 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1160717012516 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1160717012517 active site 1160717012518 catalytic site [active] 1160717012519 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1160717012520 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1160717012521 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1160717012522 low affinity gluconate transporter; Provisional; Region: PRK10472 1160717012523 gluconate transporter; Region: gntP; TIGR00791 1160717012524 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1160717012525 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1160717012526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717012527 DNA binding site [nucleotide binding] 1160717012528 domain linker motif; other site 1160717012529 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1160717012530 putative ligand binding site [chemical binding]; other site 1160717012531 putative dimerization interface [polypeptide binding]; other site 1160717012532 Pirin-related protein [General function prediction only]; Region: COG1741 1160717012533 Pirin; Region: Pirin; pfam02678 1160717012534 putative oxidoreductase; Provisional; Region: PRK10206 1160717012535 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1160717012536 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1160717012537 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1160717012538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717012539 Coenzyme A binding pocket [chemical binding]; other site 1160717012540 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1160717012541 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1160717012542 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717012543 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1160717012544 substrate binding site [chemical binding]; other site 1160717012545 dimer interface [polypeptide binding]; other site 1160717012546 ATP binding site [chemical binding]; other site 1160717012547 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1160717012548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1160717012549 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1160717012550 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1160717012551 active site 1160717012552 substrate binding pocket [chemical binding]; other site 1160717012553 homodimer interaction site [polypeptide binding]; other site 1160717012554 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1160717012555 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1160717012556 hypothetical protein; Provisional; Region: PRK10350 1160717012557 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1160717012558 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1160717012559 putative active site [active] 1160717012560 catalytic site [active] 1160717012561 putative metal binding site [ion binding]; other site 1160717012562 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1160717012563 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1160717012564 Walker A/P-loop; other site 1160717012565 ATP binding site [chemical binding]; other site 1160717012566 Q-loop/lid; other site 1160717012567 ABC transporter signature motif; other site 1160717012568 Walker B; other site 1160717012569 D-loop; other site 1160717012570 H-loop/switch region; other site 1160717012571 TOBE domain; Region: TOBE_2; pfam08402 1160717012572 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1160717012573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717012574 dimer interface [polypeptide binding]; other site 1160717012575 conserved gate region; other site 1160717012576 ABC-ATPase subunit interface; other site 1160717012577 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1160717012578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717012579 dimer interface [polypeptide binding]; other site 1160717012580 conserved gate region; other site 1160717012581 putative PBP binding loops; other site 1160717012582 ABC-ATPase subunit interface; other site 1160717012583 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1160717012584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1160717012585 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1160717012586 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1160717012587 Walker A/P-loop; other site 1160717012588 ATP binding site [chemical binding]; other site 1160717012589 Q-loop/lid; other site 1160717012590 ABC transporter signature motif; other site 1160717012591 Walker B; other site 1160717012592 D-loop; other site 1160717012593 H-loop/switch region; other site 1160717012594 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1160717012595 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1160717012596 Walker A/P-loop; other site 1160717012597 ATP binding site [chemical binding]; other site 1160717012598 Q-loop/lid; other site 1160717012599 ABC transporter signature motif; other site 1160717012600 Walker B; other site 1160717012601 D-loop; other site 1160717012602 H-loop/switch region; other site 1160717012603 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1160717012604 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1160717012605 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1160717012606 TM-ABC transporter signature motif; other site 1160717012607 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1160717012608 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1160717012609 TM-ABC transporter signature motif; other site 1160717012610 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1160717012611 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1160717012612 dimerization interface [polypeptide binding]; other site 1160717012613 ligand binding site [chemical binding]; other site 1160717012614 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1160717012615 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1160717012616 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1160717012617 dimerization interface [polypeptide binding]; other site 1160717012618 ligand binding site [chemical binding]; other site 1160717012619 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1160717012620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1160717012621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1160717012622 DNA binding residues [nucleotide binding] 1160717012623 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1160717012624 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1160717012625 cell division protein FtsE; Provisional; Region: PRK10908 1160717012626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717012627 Walker A/P-loop; other site 1160717012628 ATP binding site [chemical binding]; other site 1160717012629 Q-loop/lid; other site 1160717012630 ABC transporter signature motif; other site 1160717012631 Walker B; other site 1160717012632 D-loop; other site 1160717012633 H-loop/switch region; other site 1160717012634 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1160717012635 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1160717012636 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1160717012637 P loop; other site 1160717012638 GTP binding site [chemical binding]; other site 1160717012639 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1160717012640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717012641 S-adenosylmethionine binding site [chemical binding]; other site 1160717012642 hypothetical protein; Provisional; Region: PRK10910 1160717012643 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1160717012644 Predicted membrane protein [Function unknown]; Region: COG3714 1160717012645 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1160717012646 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1160717012647 metal-binding site [ion binding] 1160717012648 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1160717012649 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1160717012650 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1160717012651 dimer interface [polypeptide binding]; other site 1160717012652 ligand binding site [chemical binding]; other site 1160717012653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1160717012654 dimerization interface [polypeptide binding]; other site 1160717012655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1160717012656 dimer interface [polypeptide binding]; other site 1160717012657 putative CheW interface [polypeptide binding]; other site 1160717012658 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1160717012659 CPxP motif; other site 1160717012660 hypothetical protein; Provisional; Region: PRK11212 1160717012661 hypothetical protein; Provisional; Region: PRK11615 1160717012662 major facilitator superfamily transporter; Provisional; Region: PRK05122 1160717012663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717012664 putative substrate translocation pore; other site 1160717012665 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1160717012666 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1160717012667 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1160717012668 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1160717012669 nickel responsive regulator; Provisional; Region: PRK02967 1160717012670 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1160717012671 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1160717012672 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1160717012673 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1160717012674 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1160717012675 Walker A/P-loop; other site 1160717012676 ATP binding site [chemical binding]; other site 1160717012677 Q-loop/lid; other site 1160717012678 ABC transporter signature motif; other site 1160717012679 Walker B; other site 1160717012680 D-loop; other site 1160717012681 H-loop/switch region; other site 1160717012682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1160717012683 Walker A/P-loop; other site 1160717012684 ATP binding site [chemical binding]; other site 1160717012685 Q-loop/lid; other site 1160717012686 ABC transporter signature motif; other site 1160717012687 Walker B; other site 1160717012688 D-loop; other site 1160717012689 H-loop/switch region; other site 1160717012690 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1160717012691 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1160717012692 HlyD family secretion protein; Region: HlyD; pfam00529 1160717012693 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1160717012694 HlyD family secretion protein; Region: HlyD_3; pfam13437 1160717012695 Predicted flavoproteins [General function prediction only]; Region: COG2081 1160717012696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717012697 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1160717012698 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1160717012699 universal stress protein UspB; Provisional; Region: PRK04960 1160717012700 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1160717012701 Ligand Binding Site [chemical binding]; other site 1160717012702 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1160717012703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717012704 putative substrate translocation pore; other site 1160717012705 POT family; Region: PTR2; pfam00854 1160717012706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717012707 S-adenosylmethionine binding site [chemical binding]; other site 1160717012708 oligopeptidase A; Provisional; Region: PRK10911 1160717012709 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1160717012710 active site 1160717012711 Zn binding site [ion binding]; other site 1160717012712 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1160717012713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1160717012714 active site 1160717012715 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1160717012716 glutathione reductase; Validated; Region: PRK06116 1160717012717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1160717012718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1160717012719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1160717012720 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1160717012721 active site 1160717012722 homodimer interface [polypeptide binding]; other site 1160717012723 homotetramer interface [polypeptide binding]; other site 1160717012724 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1160717012725 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1160717012726 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1160717012727 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717012728 substrate binding site [chemical binding]; other site 1160717012729 ATP binding site [chemical binding]; other site 1160717012730 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1160717012731 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1160717012732 putative active site [active] 1160717012733 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1160717012734 dimer interface [polypeptide binding]; other site 1160717012735 active site 1160717012736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1160717012737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717012738 DNA-binding site [nucleotide binding]; DNA binding site 1160717012739 UTRA domain; Region: UTRA; pfam07702 1160717012740 trehalase; Provisional; Region: treF; PRK13270 1160717012741 Trehalase; Region: Trehalase; pfam01204 1160717012742 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1160717012743 catalytic residue [active] 1160717012744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1160717012745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1160717012746 active site 1160717012747 phosphorylation site [posttranslational modification] 1160717012748 dimerization interface [polypeptide binding]; other site 1160717012749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717012750 DNA binding residues [nucleotide binding] 1160717012751 dimerization interface [polypeptide binding]; other site 1160717012752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717012753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717012754 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1160717012755 putative effector binding pocket; other site 1160717012756 putative dimerization interface [polypeptide binding]; other site 1160717012757 inner membrane protein YhjD; Region: TIGR00766 1160717012758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717012759 metabolite-proton symporter; Region: 2A0106; TIGR00883 1160717012760 putative substrate translocation pore; other site 1160717012761 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1160717012762 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1160717012763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717012764 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717012765 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1160717012766 substrate binding site [chemical binding]; other site 1160717012767 ATP binding site [chemical binding]; other site 1160717012768 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1160717012769 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1160717012770 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1160717012771 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1160717012772 putative diguanylate cyclase; Provisional; Region: PRK13561 1160717012773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1160717012774 metal binding site [ion binding]; metal-binding site 1160717012775 active site 1160717012776 I-site; other site 1160717012777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1160717012778 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1160717012779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1160717012780 TPR motif; other site 1160717012781 binding surface 1160717012782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1160717012783 binding surface 1160717012784 TPR motif; other site 1160717012785 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1160717012786 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1160717012787 cellulose synthase regulator protein; Provisional; Region: PRK11114 1160717012788 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1160717012789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717012790 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1160717012791 DXD motif; other site 1160717012792 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717012793 PilZ domain; Region: PilZ; pfam07238 1160717012794 cell division protein; Provisional; Region: PRK10037 1160717012795 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1160717012796 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1160717012797 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1160717012798 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1160717012799 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1160717012800 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1160717012801 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1160717012802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1160717012803 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1160717012804 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1160717012805 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1160717012806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717012807 Walker A/P-loop; other site 1160717012808 ATP binding site [chemical binding]; other site 1160717012809 Q-loop/lid; other site 1160717012810 ABC transporter signature motif; other site 1160717012811 Walker B; other site 1160717012812 D-loop; other site 1160717012813 H-loop/switch region; other site 1160717012814 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1160717012815 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1160717012816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1160717012817 Walker A/P-loop; other site 1160717012818 ATP binding site [chemical binding]; other site 1160717012819 Q-loop/lid; other site 1160717012820 ABC transporter signature motif; other site 1160717012821 Walker B; other site 1160717012822 D-loop; other site 1160717012823 H-loop/switch region; other site 1160717012824 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1160717012825 dipeptide transporter; Provisional; Region: PRK10913 1160717012826 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1160717012827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717012828 dimer interface [polypeptide binding]; other site 1160717012829 conserved gate region; other site 1160717012830 putative PBP binding loops; other site 1160717012831 ABC-ATPase subunit interface; other site 1160717012832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1160717012833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717012834 dimer interface [polypeptide binding]; other site 1160717012835 conserved gate region; other site 1160717012836 putative PBP binding loops; other site 1160717012837 ABC-ATPase subunit interface; other site 1160717012838 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1160717012839 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1160717012840 peptide binding site [polypeptide binding]; other site 1160717012841 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1160717012842 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1160717012843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1160717012844 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717012845 DNA binding site [nucleotide binding] 1160717012846 domain linker motif; other site 1160717012847 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1160717012848 putative dimerization interface [polypeptide binding]; other site 1160717012849 putative ligand binding site [chemical binding]; other site 1160717012850 phosphoethanolamine transferase; Provisional; Region: PRK11560 1160717012851 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1160717012852 Sulfatase; Region: Sulfatase; pfam00884 1160717012853 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1160717012854 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 1160717012855 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 1160717012856 PapC N-terminal domain; Region: PapC_N; pfam13954 1160717012857 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1160717012858 PapC C-terminal domain; Region: PapC_C; pfam13953 1160717012859 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1160717012860 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1160717012861 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1160717012862 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1160717012863 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1160717012864 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1160717012865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717012866 Coenzyme A binding pocket [chemical binding]; other site 1160717012867 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1160717012868 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1160717012869 molybdopterin cofactor binding site [chemical binding]; other site 1160717012870 substrate binding site [chemical binding]; other site 1160717012871 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1160717012872 molybdopterin cofactor binding site; other site 1160717012873 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1160717012874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1160717012875 ligand binding site [chemical binding]; other site 1160717012876 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1160717012877 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1160717012878 dimerization interface [polypeptide binding]; other site 1160717012879 ligand binding site [chemical binding]; other site 1160717012880 NADP binding site [chemical binding]; other site 1160717012881 catalytic site [active] 1160717012882 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1160717012883 Predicted transcriptional regulator [Transcription]; Region: COG2944 1160717012884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717012885 salt bridge; other site 1160717012886 non-specific DNA binding site [nucleotide binding]; other site 1160717012887 sequence-specific DNA binding site [nucleotide binding]; other site 1160717012888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1160717012889 DNA-binding site [nucleotide binding]; DNA binding site 1160717012890 RNA-binding motif; other site 1160717012891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1160717012892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1160717012893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1160717012894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1160717012895 Coenzyme A binding pocket [chemical binding]; other site 1160717012896 Integrase core domain; Region: rve; pfam00665 1160717012897 Integrase core domain; Region: rve_2; pfam13333 1160717012898 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1160717012899 DALR anticodon binding domain; Region: DALR_1; pfam05746 1160717012900 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1160717012901 dimer interface [polypeptide binding]; other site 1160717012902 motif 1; other site 1160717012903 active site 1160717012904 motif 2; other site 1160717012905 motif 3; other site 1160717012906 YsaB-like lipoprotein; Region: YsaB; pfam13983 1160717012907 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1160717012908 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1160717012909 Predicted membrane protein [Function unknown]; Region: COG4682 1160717012910 yiaA/B two helix domain; Region: YiaAB; cl01759 1160717012911 yiaA/B two helix domain; Region: YiaAB; cl01759 1160717012912 xylulokinase; Provisional; Region: PRK15027 1160717012913 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1160717012914 N- and C-terminal domain interface [polypeptide binding]; other site 1160717012915 active site 1160717012916 MgATP binding site [chemical binding]; other site 1160717012917 catalytic site [active] 1160717012918 metal binding site [ion binding]; metal-binding site 1160717012919 xylulose binding site [chemical binding]; other site 1160717012920 homodimer interface [polypeptide binding]; other site 1160717012921 xylose isomerase; Provisional; Region: PRK05474 1160717012922 xylose isomerase; Region: xylose_isom_A; TIGR02630 1160717012923 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1160717012924 putative dimerization interface [polypeptide binding]; other site 1160717012925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1160717012926 putative ligand binding site [chemical binding]; other site 1160717012927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717012928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1160717012929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717012930 hypothetical protein; Provisional; Region: PRK10356 1160717012931 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1160717012932 alpha-amylase; Reviewed; Region: malS; PRK09505 1160717012933 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1160717012934 active site 1160717012935 catalytic site [active] 1160717012936 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1160717012937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1160717012938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717012939 homodimer interface [polypeptide binding]; other site 1160717012940 catalytic residue [active] 1160717012941 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1160717012942 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1160717012943 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1160717012944 Bacterial transcriptional regulator; Region: IclR; pfam01614 1160717012945 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1160717012946 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1160717012947 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1160717012948 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1160717012949 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1160717012950 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1160717012951 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1160717012952 putative N- and C-terminal domain interface [polypeptide binding]; other site 1160717012953 putative active site [active] 1160717012954 MgATP binding site [chemical binding]; other site 1160717012955 catalytic site [active] 1160717012956 metal binding site [ion binding]; metal-binding site 1160717012957 putative xylulose binding site [chemical binding]; other site 1160717012958 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1160717012959 active site 1160717012960 dimer interface [polypeptide binding]; other site 1160717012961 magnesium binding site [ion binding]; other site 1160717012962 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1160717012963 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1160717012964 AP (apurinic/apyrimidinic) site pocket; other site 1160717012965 DNA interaction; other site 1160717012966 Metal-binding active site; metal-binding site 1160717012967 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1160717012968 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1160717012969 intersubunit interface [polypeptide binding]; other site 1160717012970 active site 1160717012971 Zn2+ binding site [ion binding]; other site 1160717012972 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1160717012973 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1160717012974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1160717012975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1160717012976 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1160717012977 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1160717012978 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1160717012979 NAD(P) binding site [chemical binding]; other site 1160717012980 catalytic residues [active] 1160717012981 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1160717012982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1160717012983 nucleotide binding site [chemical binding]; other site 1160717012984 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1160717012985 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1160717012986 G1 box; other site 1160717012987 putative GEF interaction site [polypeptide binding]; other site 1160717012988 GTP/Mg2+ binding site [chemical binding]; other site 1160717012989 Switch I region; other site 1160717012990 G2 box; other site 1160717012991 G3 box; other site 1160717012992 Switch II region; other site 1160717012993 G4 box; other site 1160717012994 G5 box; other site 1160717012995 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1160717012996 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1160717012997 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1160717012998 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1160717012999 selenocysteine synthase; Provisional; Region: PRK04311 1160717013000 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1160717013001 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1160717013002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717013003 catalytic residue [active] 1160717013004 putative glutathione S-transferase; Provisional; Region: PRK10357 1160717013005 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1160717013006 putative C-terminal domain interface [polypeptide binding]; other site 1160717013007 putative GSH binding site (G-site) [chemical binding]; other site 1160717013008 putative dimer interface [polypeptide binding]; other site 1160717013009 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1160717013010 dimer interface [polypeptide binding]; other site 1160717013011 N-terminal domain interface [polypeptide binding]; other site 1160717013012 putative substrate binding pocket (H-site) [chemical binding]; other site 1160717013013 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1160717013014 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1160717013015 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1160717013016 active site 1160717013017 P-loop; other site 1160717013018 phosphorylation site [posttranslational modification] 1160717013019 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717013020 active site 1160717013021 phosphorylation site [posttranslational modification] 1160717013022 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1160717013023 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1160717013024 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1160717013025 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1160717013026 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1160717013027 hypothetical protein; Provisional; Region: PRK11020 1160717013028 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1160717013029 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1160717013030 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1160717013031 trimer interface [polypeptide binding]; other site 1160717013032 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1160717013033 Haemagglutinin; Region: HIM; pfam05662 1160717013034 Haemagglutinin; Region: HIM; pfam05662 1160717013035 YadA-like C-terminal region; Region: YadA; pfam03895 1160717013036 L-lactate permease; Provisional; Region: PRK10420 1160717013037 glycolate transporter; Provisional; Region: PRK09695 1160717013038 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1160717013039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717013040 DNA-binding site [nucleotide binding]; DNA binding site 1160717013041 FCD domain; Region: FCD; pfam07729 1160717013042 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1160717013043 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1160717013044 active site 1160717013045 substrate binding site [chemical binding]; other site 1160717013046 FMN binding site [chemical binding]; other site 1160717013047 putative catalytic residues [active] 1160717013048 putative rRNA methylase; Provisional; Region: PRK10358 1160717013049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1160717013050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1160717013051 DNA binding site [nucleotide binding] 1160717013052 domain linker motif; other site 1160717013053 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1160717013054 putative dimerization interface [polypeptide binding]; other site 1160717013055 putative ligand binding site [chemical binding]; other site 1160717013056 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1160717013057 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1160717013058 active site pocket [active] 1160717013059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013060 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717013061 putative substrate translocation pore; other site 1160717013062 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1160717013063 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1160717013064 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1160717013065 trimer interface [polypeptide binding]; other site 1160717013066 active site 1160717013067 substrate binding site [chemical binding]; other site 1160717013068 CoA binding site [chemical binding]; other site 1160717013069 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1160717013070 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1160717013071 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1160717013072 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1160717013073 SecA binding site; other site 1160717013074 Preprotein binding site; other site 1160717013075 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1160717013076 GSH binding site [chemical binding]; other site 1160717013077 catalytic residues [active] 1160717013078 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1160717013079 active site residue [active] 1160717013080 phosphoglyceromutase; Provisional; Region: PRK05434 1160717013081 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1160717013082 AmiB activator; Provisional; Region: PRK11637 1160717013083 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1160717013084 Peptidase family M23; Region: Peptidase_M23; pfam01551 1160717013085 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1160717013086 NodB motif; other site 1160717013087 putative active site [active] 1160717013088 putative catalytic site [active] 1160717013089 Zn binding site [ion binding]; other site 1160717013090 putative glycosyl transferase; Provisional; Region: PRK10073 1160717013091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1160717013092 active site 1160717013093 genomic island 1160717013094 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1160717013095 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1160717013096 NAD(P) binding site [chemical binding]; other site 1160717013097 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1160717013098 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1160717013099 substrate-cofactor binding pocket; other site 1160717013100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1160717013101 catalytic residue [active] 1160717013102 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1160717013103 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1160717013104 NADP binding site [chemical binding]; other site 1160717013105 homopentamer interface [polypeptide binding]; other site 1160717013106 substrate binding site [chemical binding]; other site 1160717013107 active site 1160717013108 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1160717013109 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1160717013110 putative active site [active] 1160717013111 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1160717013112 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1160717013113 putative active site [active] 1160717013114 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1160717013115 O-antigen ligase RfaL; Provisional; Region: PRK15487 1160717013116 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1160717013117 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1160717013118 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1160717013119 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1160717013120 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1160717013121 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1160717013122 Ligand binding site; other site 1160717013123 metal-binding site 1160717013124 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1160717013125 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1160717013126 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1160717013127 Ligand binding site; other site 1160717013128 metal-binding site 1160717013129 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1160717013130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1160717013131 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1160717013132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1160717013133 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1160717013134 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1160717013135 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1160717013136 putative active site [active] 1160717013137 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1160717013138 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1160717013139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1160717013140 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1160717013141 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1160717013142 active site 1160717013143 (T/H)XGH motif; other site 1160717013144 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1160717013145 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1160717013146 DNA binding site [nucleotide binding] 1160717013147 catalytic residue [active] 1160717013148 H2TH interface [polypeptide binding]; other site 1160717013149 putative catalytic residues [active] 1160717013150 turnover-facilitating residue; other site 1160717013151 intercalation triad [nucleotide binding]; other site 1160717013152 8OG recognition residue [nucleotide binding]; other site 1160717013153 putative reading head residues; other site 1160717013154 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1160717013155 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1160717013156 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1160717013157 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1160717013158 hypothetical protein; Reviewed; Region: PRK00024 1160717013159 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1160717013160 MPN+ (JAMM) motif; other site 1160717013161 Zinc-binding site [ion binding]; other site 1160717013162 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1160717013163 Flavoprotein; Region: Flavoprotein; pfam02441 1160717013164 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1160717013165 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1160717013166 trimer interface [polypeptide binding]; other site 1160717013167 active site 1160717013168 division inhibitor protein; Provisional; Region: slmA; PRK09480 1160717013169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1160717013170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1160717013171 active site 1160717013172 ribonuclease PH; Reviewed; Region: rph; PRK00173 1160717013173 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1160717013174 hexamer interface [polypeptide binding]; other site 1160717013175 active site 1160717013176 hypothetical protein; Provisional; Region: PRK11820 1160717013177 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1160717013178 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1160717013179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717013180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717013181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1160717013182 dimerization interface [polypeptide binding]; other site 1160717013183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1160717013184 Predicted membrane protein [Function unknown]; Region: COG2860 1160717013185 UPF0126 domain; Region: UPF0126; pfam03458 1160717013186 UPF0126 domain; Region: UPF0126; pfam03458 1160717013187 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1160717013188 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1160717013189 nucleotide binding pocket [chemical binding]; other site 1160717013190 K-X-D-G motif; other site 1160717013191 catalytic site [active] 1160717013192 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1160717013193 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1160717013194 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1160717013195 catalytic site [active] 1160717013196 G-X2-G-X-G-K; other site 1160717013197 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1160717013198 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1160717013199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1160717013200 Zn2+ binding site [ion binding]; other site 1160717013201 Mg2+ binding site [ion binding]; other site 1160717013202 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1160717013203 synthetase active site [active] 1160717013204 NTP binding site [chemical binding]; other site 1160717013205 metal binding site [ion binding]; metal-binding site 1160717013206 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1160717013207 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1160717013208 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1160717013209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1160717013210 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1160717013211 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1160717013212 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1160717013213 generic binding surface II; other site 1160717013214 ssDNA binding site; other site 1160717013215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717013216 ATP binding site [chemical binding]; other site 1160717013217 putative Mg++ binding site [ion binding]; other site 1160717013218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1160717013219 nucleotide binding region [chemical binding]; other site 1160717013220 ATP-binding site [chemical binding]; other site 1160717013221 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1160717013222 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1160717013223 AsmA family; Region: AsmA; pfam05170 1160717013224 putative alpha-glucosidase; Provisional; Region: PRK10658 1160717013225 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1160717013226 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1160717013227 active site 1160717013228 homotrimer interface [polypeptide binding]; other site 1160717013229 catalytic site [active] 1160717013230 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1160717013231 putative transporter; Provisional; Region: PRK11462 1160717013232 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1160717013233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717013234 AAA domain; Region: AAA_23; pfam13476 1160717013235 Walker A/P-loop; other site 1160717013236 ATP binding site [chemical binding]; other site 1160717013237 AAA domain; Region: AAA_21; pfam13304 1160717013238 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1160717013239 Virulence protein [General function prediction only]; Region: COG3943 1160717013240 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1160717013241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1160717013242 Transposase; Region: HTH_Tnp_1; pfam01527 1160717013243 autotransport protein MisL; Provisional; Region: PRK15313 1160717013244 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1160717013245 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1160717013246 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1160717013247 DNA binding site [nucleotide binding] 1160717013248 Isochorismatase family; Region: Isochorismatase; pfam00857 1160717013249 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1160717013250 catalytic triad [active] 1160717013251 dimer interface [polypeptide binding]; other site 1160717013252 conserved cis-peptide bond; other site 1160717013253 magnesium-transporting ATPase; Provisional; Region: PRK15122 1160717013254 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1160717013255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1160717013256 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1160717013257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717013258 motif II; other site 1160717013259 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1160717013260 magnesium transport protein MgtC; Provisional; Region: PRK15385 1160717013261 MgtC family; Region: MgtC; pfam02308 1160717013262 EamA-like transporter family; Region: EamA; pfam00892 1160717013263 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1160717013264 EamA-like transporter family; Region: EamA; pfam00892 1160717013265 hypothetical protein; Provisional; Region: PRK09956 1160717013266 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1160717013267 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1160717013268 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1160717013269 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1160717013270 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1160717013271 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1160717013272 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1160717013273 active site 1160717013274 phosphorylation site [posttranslational modification] 1160717013275 genomic island 1160717013276 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1160717013277 active pocket/dimerization site; other site 1160717013278 active site 1160717013279 phosphorylation site [posttranslational modification] 1160717013280 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1160717013281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717013282 Walker A motif; other site 1160717013283 ATP binding site [chemical binding]; other site 1160717013284 Walker B motif; other site 1160717013285 arginine finger; other site 1160717013286 Transcriptional antiterminator [Transcription]; Region: COG3933 1160717013287 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1160717013288 active site 1160717013289 active pocket/dimerization site; other site 1160717013290 phosphorylation site [posttranslational modification] 1160717013291 PRD domain; Region: PRD; pfam00874 1160717013292 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1160717013293 beta-galactosidase; Region: BGL; TIGR03356 1160717013294 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1160717013295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013296 putative substrate translocation pore; other site 1160717013297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1160717013298 Predicted transcriptional regulator [Transcription]; Region: COG2944 1160717013299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1160717013300 non-specific DNA binding site [nucleotide binding]; other site 1160717013301 salt bridge; other site 1160717013302 sequence-specific DNA binding site [nucleotide binding]; other site 1160717013303 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1160717013304 dimerization domain swap beta strand [polypeptide binding]; other site 1160717013305 regulatory protein interface [polypeptide binding]; other site 1160717013306 active site 1160717013307 regulatory phosphorylation site [posttranslational modification]; other site 1160717013308 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1160717013309 intersubunit interface [polypeptide binding]; other site 1160717013310 active site 1160717013311 zinc binding site [ion binding]; other site 1160717013312 Na+ binding site [ion binding]; other site 1160717013313 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1160717013314 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1160717013315 putative N- and C-terminal domain interface [polypeptide binding]; other site 1160717013316 putative active site [active] 1160717013317 putative MgATP binding site [chemical binding]; other site 1160717013318 catalytic site [active] 1160717013319 metal binding site [ion binding]; metal-binding site 1160717013320 putative carbohydrate binding site [chemical binding]; other site 1160717013321 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1160717013322 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1160717013323 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1160717013324 active site 1160717013325 P-loop; other site 1160717013326 phosphorylation site [posttranslational modification] 1160717013327 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1160717013328 active site 1160717013329 phosphorylation site [posttranslational modification] 1160717013330 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1160717013331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717013332 DNA-binding site [nucleotide binding]; DNA binding site 1160717013333 UTRA domain; Region: UTRA; pfam07702 1160717013334 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1160717013335 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1160717013336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013337 putative substrate translocation pore; other site 1160717013338 regulatory protein UhpC; Provisional; Region: PRK11663 1160717013339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013340 putative substrate translocation pore; other site 1160717013341 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1160717013342 MASE1; Region: MASE1; pfam05231 1160717013343 Histidine kinase; Region: HisKA_3; pfam07730 1160717013344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717013345 ATP binding site [chemical binding]; other site 1160717013346 Mg2+ binding site [ion binding]; other site 1160717013347 G-X-G motif; other site 1160717013348 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1160717013349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717013350 active site 1160717013351 phosphorylation site [posttranslational modification] 1160717013352 intermolecular recognition site; other site 1160717013353 dimerization interface [polypeptide binding]; other site 1160717013354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1160717013355 DNA binding residues [nucleotide binding] 1160717013356 dimerization interface [polypeptide binding]; other site 1160717013357 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1160717013358 active site 1160717013359 catalytic residues [active] 1160717013360 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1160717013361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013362 putative substrate translocation pore; other site 1160717013363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1160717013364 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1160717013365 substrate binding site [chemical binding]; other site 1160717013366 dimer interface [polypeptide binding]; other site 1160717013367 ATP binding site [chemical binding]; other site 1160717013368 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1160717013369 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1160717013370 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1160717013371 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1160717013372 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1160717013373 putative valine binding site [chemical binding]; other site 1160717013374 dimer interface [polypeptide binding]; other site 1160717013375 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1160717013376 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1160717013377 PYR/PP interface [polypeptide binding]; other site 1160717013378 dimer interface [polypeptide binding]; other site 1160717013379 TPP binding site [chemical binding]; other site 1160717013380 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1160717013381 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1160717013382 TPP-binding site [chemical binding]; other site 1160717013383 dimer interface [polypeptide binding]; other site 1160717013384 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1160717013385 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1160717013386 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1160717013387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013388 putative substrate translocation pore; other site 1160717013389 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1160717013390 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1160717013391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717013392 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1160717013393 dimerization interface [polypeptide binding]; other site 1160717013394 substrate binding pocket [chemical binding]; other site 1160717013395 permease DsdX; Provisional; Region: PRK09921 1160717013396 gluconate transporter; Region: gntP; TIGR00791 1160717013397 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1160717013398 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1160717013399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1160717013400 catalytic residue [active] 1160717013401 genomic island 1160717013402 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1160717013403 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1160717013404 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1160717013405 Predicted membrane protein [Function unknown]; Region: COG2149 1160717013406 putative transporter; Validated; Region: PRK03818 1160717013407 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1160717013408 TrkA-C domain; Region: TrkA_C; pfam02080 1160717013409 TrkA-C domain; Region: TrkA_C; pfam02080 1160717013410 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1160717013411 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1160717013412 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1160717013413 putative dimer interface [polypeptide binding]; other site 1160717013414 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1160717013415 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1160717013416 putative dimer interface [polypeptide binding]; other site 1160717013417 hypothetical protein; Provisional; Region: PRK11616 1160717013418 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1160717013419 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1160717013420 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1160717013421 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1160717013422 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1160717013423 catalytic residues [active] 1160717013424 central insert; other site 1160717013425 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1160717013426 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1160717013427 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1160717013428 heme exporter protein CcmC; Region: ccmC; TIGR01191 1160717013429 heme exporter protein CcmB; Region: ccmB; TIGR01190 1160717013430 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1160717013431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717013432 Walker A/P-loop; other site 1160717013433 ATP binding site [chemical binding]; other site 1160717013434 Q-loop/lid; other site 1160717013435 ABC transporter signature motif; other site 1160717013436 Walker B; other site 1160717013437 D-loop; other site 1160717013438 H-loop/switch region; other site 1160717013439 Haem-binding domain; Region: Haem_bd; pfam14376 1160717013440 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1160717013441 chaperone protein TorD; Validated; Region: torD; PRK04976 1160717013442 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1160717013443 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1160717013444 molybdopterin cofactor binding site [chemical binding]; other site 1160717013445 substrate binding site [chemical binding]; other site 1160717013446 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1160717013447 molybdopterin cofactor binding site; other site 1160717013448 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1160717013449 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1160717013450 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1160717013451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717013452 active site 1160717013453 phosphorylation site [posttranslational modification] 1160717013454 intermolecular recognition site; other site 1160717013455 dimerization interface [polypeptide binding]; other site 1160717013456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1160717013457 DNA binding site [nucleotide binding] 1160717013458 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1160717013459 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1160717013460 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1160717013461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1160717013462 dimer interface [polypeptide binding]; other site 1160717013463 phosphorylation site [posttranslational modification] 1160717013464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717013465 ATP binding site [chemical binding]; other site 1160717013466 Mg2+ binding site [ion binding]; other site 1160717013467 G-X-G motif; other site 1160717013468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1160717013469 active site 1160717013470 phosphorylation site [posttranslational modification] 1160717013471 intermolecular recognition site; other site 1160717013472 dimerization interface [polypeptide binding]; other site 1160717013473 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1160717013474 putative binding surface; other site 1160717013475 active site 1160717013476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013477 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717013478 putative substrate translocation pore; other site 1160717013479 galactonate dehydratase; Provisional; Region: PRK14017 1160717013480 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1160717013481 putative active site pocket [active] 1160717013482 putative metal binding site [ion binding]; other site 1160717013483 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1160717013484 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1160717013485 active site 1160717013486 intersubunit interface [polypeptide binding]; other site 1160717013487 catalytic residue [active] 1160717013488 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1160717013489 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1160717013490 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1160717013491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1160717013492 DNA-binding site [nucleotide binding]; DNA binding site 1160717013493 FCD domain; Region: FCD; pfam07729 1160717013494 sugar phosphate phosphatase; Provisional; Region: PRK10513 1160717013495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717013496 active site 1160717013497 motif I; other site 1160717013498 motif II; other site 1160717013499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717013500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013501 D-galactonate transporter; Region: 2A0114; TIGR00893 1160717013502 putative substrate translocation pore; other site 1160717013503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013504 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1160717013505 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1160717013506 active site pocket [active] 1160717013507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1160717013508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717013509 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1160717013510 putative dimerization interface [polypeptide binding]; other site 1160717013511 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1160717013512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1160717013513 Mg2+ binding site [ion binding]; other site 1160717013514 G-X-G motif; other site 1160717013515 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1160717013516 anchoring element; other site 1160717013517 dimer interface [polypeptide binding]; other site 1160717013518 ATP binding site [chemical binding]; other site 1160717013519 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1160717013520 active site 1160717013521 putative metal-binding site [ion binding]; other site 1160717013522 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1160717013523 recF protein; Region: recf; TIGR00611 1160717013524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717013525 Walker A/P-loop; other site 1160717013526 ATP binding site [chemical binding]; other site 1160717013527 Q-loop/lid; other site 1160717013528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1160717013529 ABC transporter signature motif; other site 1160717013530 Walker B; other site 1160717013531 D-loop; other site 1160717013532 H-loop/switch region; other site 1160717013533 DNA polymerase III subunit beta; Validated; Region: PRK05643 1160717013534 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1160717013535 putative DNA binding surface [nucleotide binding]; other site 1160717013536 dimer interface [polypeptide binding]; other site 1160717013537 beta-clamp/clamp loader binding surface; other site 1160717013538 beta-clamp/translesion DNA polymerase binding surface; other site 1160717013539 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1160717013540 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1160717013541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1160717013542 Walker A motif; other site 1160717013543 ATP binding site [chemical binding]; other site 1160717013544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1160717013545 Walker B motif; other site 1160717013546 arginine finger; other site 1160717013547 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1160717013548 DnaA box-binding interface [nucleotide binding]; other site 1160717013549 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1160717013550 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1160717013551 hypothetical protein; Validated; Region: PRK00041 1160717013552 membrane protein insertase; Provisional; Region: PRK01318 1160717013553 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1160717013554 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1160717013555 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1160717013556 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1160717013557 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1160717013558 G1 box; other site 1160717013559 GTP/Mg2+ binding site [chemical binding]; other site 1160717013560 Switch I region; other site 1160717013561 G2 box; other site 1160717013562 Switch II region; other site 1160717013563 G3 box; other site 1160717013564 G4 box; other site 1160717013565 G5 box; other site 1160717013566 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1160717013567 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1160717013568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1160717013569 putative substrate translocation pore; other site 1160717013570 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1160717013571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1160717013572 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1160717013573 substrate binding pocket [chemical binding]; other site 1160717013574 dimerization interface [polypeptide binding]; other site 1160717013575 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1160717013576 Predicted flavoprotein [General function prediction only]; Region: COG0431 1160717013577 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1160717013578 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1160717013579 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1160717013580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1160717013581 active site 1160717013582 motif I; other site 1160717013583 motif II; other site 1160717013584 transcriptional regulator PhoU; Provisional; Region: PRK11115 1160717013585 PhoU domain; Region: PhoU; pfam01895 1160717013586 PhoU domain; Region: PhoU; pfam01895 1160717013587 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1160717013588 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1160717013589 Walker A/P-loop; other site 1160717013590 ATP binding site [chemical binding]; other site 1160717013591 Q-loop/lid; other site 1160717013592 ABC transporter signature motif; other site 1160717013593 Walker B; other site 1160717013594 D-loop; other site 1160717013595 H-loop/switch region; other site 1160717013596 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1160717013597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717013598 dimer interface [polypeptide binding]; other site 1160717013599 conserved gate region; other site 1160717013600 putative PBP binding loops; other site 1160717013601 ABC-ATPase subunit interface; other site 1160717013602 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1160717013603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1160717013604 dimer interface [polypeptide binding]; other site 1160717013605 conserved gate region; other site 1160717013606 putative PBP binding loops; other site 1160717013607 ABC-ATPase subunit interface; other site 1160717013608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1160717013609 substrate binding pocket [chemical binding]; other site 1160717013610 membrane-bound complex binding site; other site 1160717013611 hinge residues; other site 1160717013612 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1160717013613 active site 1160717013614 P-loop; other site 1160717013615 phosphorylation site [posttranslational modification] 1160717013616 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1160717013617 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1160717013618 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1160717013619 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1160717013620 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1160717013621 shikimate binding site; other site 1160717013622 NAD(P) binding site [chemical binding]; other site 1160717013623 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1160717013624 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1160717013625 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1160717013626 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1160717013627 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1160717013628 glutaminase active site [active] 1160717013629 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1160717013630 dimer interface [polypeptide binding]; other site 1160717013631 active site 1160717013632 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1160717013633 dimer interface [polypeptide binding]; other site 1160717013634 active site 1160717013635 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1160717013636 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1160717013637 Substrate binding site; other site 1160717013638 Mg++ binding site; other site 1160717013639 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1160717013640 active site 1160717013641 substrate binding site [chemical binding]; other site 1160717013642 CoA binding site [chemical binding]; other site 1160717013643 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1160717013644 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1160717013645 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1160717013646 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1160717013647 gamma subunit interface [polypeptide binding]; other site 1160717013648 epsilon subunit interface [polypeptide binding]; other site 1160717013649 LBP interface [polypeptide binding]; other site 1160717013650 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1160717013651 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1160717013652 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1160717013653 alpha subunit interaction interface [polypeptide binding]; other site 1160717013654 Walker A motif; other site 1160717013655 ATP binding site [chemical binding]; other site 1160717013656 Walker B motif; other site 1160717013657 inhibitor binding site; inhibition site 1160717013658 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1160717013659 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1160717013660 core domain interface [polypeptide binding]; other site 1160717013661 delta subunit interface [polypeptide binding]; other site 1160717013662 epsilon subunit interface [polypeptide binding]; other site 1160717013663 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1160717013664 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1160717013665 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1160717013666 beta subunit interaction interface [polypeptide binding]; other site 1160717013667 Walker A motif; other site 1160717013668 ATP binding site [chemical binding]; other site 1160717013669 Walker B motif; other site 1160717013670 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1160717013671 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1160717013672 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1160717013673 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1160717013674 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1160717013675 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1160717013676 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1160717013677 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1160717013678 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1160717013679 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1160717013680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1160717013681 S-adenosylmethionine binding site [chemical binding]; other site 1160717013682 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1160717013683 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1160717013684 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1160717013685 Winged helix-turn helix; Region: HTH_29; pfam13551 1160717013686 Helix-turn-helix domain; Region: HTH_28; pfam13518 1160717013687 Integrase core domain; Region: rve_3; pfam13683 1160717013688 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1160717013689 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1160717013690 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1160717013691 Haemolysin expression modulating protein; Region: HHA; pfam05321 1160717013692 DNA topoisomerase III; Provisional; Region: PRK07726 1160717013693 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1160717013694 active site 1160717013695 putative interdomain interaction site [polypeptide binding]; other site 1160717013696 putative metal-binding site [ion binding]; other site 1160717013697 putative nucleotide binding site [chemical binding]; other site 1160717013698 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1160717013699 domain I; other site 1160717013700 DNA binding groove [nucleotide binding] 1160717013701 phosphate binding site [ion binding]; other site 1160717013702 domain II; other site 1160717013703 domain III; other site 1160717013704 nucleotide binding site [chemical binding]; other site 1160717013705 catalytic site [active] 1160717013706 domain IV; other site 1160717013707 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1160717013708 TrbM; Region: TrbM; pfam07424 1160717013709 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 1160717013710 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1160717013711 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1160717013712 Walker A motif; other site 1160717013713 ATP binding site [chemical binding]; other site 1160717013714 Walker B motif; other site 1160717013715 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1160717013716 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1160717013717 ATP binding site [chemical binding]; other site 1160717013718 Walker A motif; other site 1160717013719 hexamer interface [polypeptide binding]; other site 1160717013720 Walker B motif; other site 1160717013721 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1160717013722 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1160717013723 VirB7 interaction site; other site 1160717013724 VirB8 protein; Region: VirB8; pfam04335 1160717013725 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1160717013726 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1160717013727 Type IV secretion system proteins; Region: T4SS; pfam07996 1160717013728 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 1160717013729 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1160717013730 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1160717013731 TrbC/VIRB2 family; Region: TrbC; pfam04956 1160717013732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1160717013733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1160717013734 catalytic residue [active] 1160717013735 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894 1160717013736 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1160717013737 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1160717013738 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1160717013739 primosomal protein DnaI; Provisional; Region: PRK02854 1160717013740 RelB antitoxin; Region: RelB; cl01171 1160717013741 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1160717013742 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1160717013743 catalytic residues [active] 1160717013744 catalytic nucleophile [active] 1160717013745 Homeodomain-like domain; Region: HTH_23; cl17451 1160717013746 AAA domain; Region: AAA_21; pfam13304 1160717013747 Superfamily II helicase [General function prediction only]; Region: COG1204 1160717013748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1160717013749 ATP binding site [chemical binding]; other site 1160717013750 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460