-- dump date 20140620_053820 -- class Genbank::misc_feature -- table misc_feature_note -- id note 454169000001 IncFII RepA protein family; Region: IncFII_repA; cl11495 454169000002 Predicted transcriptional regulator [Transcription]; Region: COG3905 454169000003 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 454169000004 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 454169000005 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 454169000006 active site 454169000007 catalytic site [active] 454169000008 substrate binding site [chemical binding]; other site 454169000009 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 454169000010 putative kissing complex interaction region; other site 454169000011 putative RNA binding sites [nucleotide binding]; other site 454169000012 Colicin Ia; Region: Colicin_Ia; pfam11504 454169000013 Colicin pore forming domain; Region: Colicin; pfam01024 454169000014 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 454169000015 Phage integrase family; Region: Phage_integrase; pfam00589 454169000016 active site 454169000017 DNA binding site [nucleotide binding] 454169000018 Int/Topo IB signature motif; other site 454169000019 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 454169000020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 454169000021 P-loop; other site 454169000022 Magnesium ion binding site [ion binding]; other site 454169000023 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 454169000024 Mg binding site [ion binding]; other site 454169000025 nucleotide binding site [chemical binding]; other site 454169000026 putative protofilament interface [polypeptide binding]; other site 454169000027 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 454169000028 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 454169000029 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 454169000030 active site 454169000031 DNA binding site [nucleotide binding] 454169000032 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 454169000033 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 454169000034 Catalytic site [active] 454169000035 DinI-like family; Region: DinI; pfam06183 454169000036 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 454169000037 putative methylase; Provisional; Region: PRK13699 454169000038 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 454169000039 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 454169000040 Antirestriction protein; Region: Antirestrict; pfam03230 454169000041 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 454169000042 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 454169000043 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 454169000044 dimer interface [polypeptide binding]; other site 454169000045 ssDNA binding site [nucleotide binding]; other site 454169000046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454169000047 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 454169000048 ParB-like nuclease domain; Region: ParBc; pfam02195 454169000049 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 454169000050 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 454169000051 PsiA protein; Region: PsiA; cl11646 454169000052 Antirestriction protein (ArdA); Region: ArdA; pfam07275 454169000053 putative transposase; Provisional; Region: PRK09857 454169000054 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454169000055 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 454169000056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 454169000057 non-specific DNA binding site [nucleotide binding]; other site 454169000058 salt bridge; other site 454169000059 sequence-specific DNA binding site [nucleotide binding]; other site 454169000060 Methyltransferase domain; Region: Methyltransf_27; pfam13708 454169000061 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 454169000062 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 454169000063 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 454169000064 dimerization domain [polypeptide binding]; other site 454169000065 dimer interface [polypeptide binding]; other site 454169000066 catalytic residues [active] 454169000067 Hok/gef family; Region: HOK_GEF; pfam01848 454169000068 HEAT repeats; Region: HEAT_2; pfam13646 454169000069 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 454169000070 indole-3-acetamide amidohydrolase; Region: PLN02722 454169000071 AAA-like domain; Region: AAA_10; pfam12846 454169000072 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 454169000073 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 454169000074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 454169000075 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 454169000076 active site 454169000077 metal binding site [ion binding]; metal-binding site 454169000078 interdomain interaction site; other site 454169000079 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 454169000080 PLD-like domain; Region: PLDc_2; pfam13091 454169000081 putative active site [active] 454169000082 catalytic site [active] 454169000083 plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525 454169000084 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454169000085 Walker A motif; other site 454169000086 ATP binding site [chemical binding]; other site 454169000087 Walker B motif; other site 454169000088 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 454169000089 catalytic core [active] 454169000090 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 454169000091 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 454169000092 catalytic residues [active] 454169000093 Int/Topo IB signature motif; other site 454169000094 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 454169000095 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 454169000096 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 454169000097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169000098 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169000099 catalytic residue [active] 454169000100 PilS N terminal; Region: PilS; pfam08805 454169000101 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 454169000102 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 454169000103 Type II/IV secretion system protein; Region: T2SE; pfam00437 454169000104 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454169000105 Walker A motif; other site 454169000106 ATP binding site [chemical binding]; other site 454169000107 Walker B motif; other site 454169000108 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 454169000109 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 454169000110 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 454169000111 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 454169000112 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454169000113 PilM; Region: PilM; pfam07419 454169000114 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 454169000115 Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623 454169000116 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 454169000117 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 454169000118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 454169000119 Rop protein; Region: Rop; pfam01815 454169000120 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 454169000121 Threonine operon leader 454169000122 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 454169000123 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 454169000124 putative catalytic residues [active] 454169000125 putative nucleotide binding site [chemical binding]; other site 454169000126 putative aspartate binding site [chemical binding]; other site 454169000127 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 454169000128 dimer interface [polypeptide binding]; other site 454169000129 putative threonine allosteric regulatory site; other site 454169000130 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 454169000131 putative threonine allosteric regulatory site; other site 454169000132 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 454169000133 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 454169000134 homoserine kinase; Provisional; Region: PRK01212 454169000135 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 454169000136 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 454169000137 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 454169000138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169000139 catalytic residue [active] 454169000140 hypothetical protein; Validated; Region: PRK02101 454169000141 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 454169000142 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 454169000143 transaldolase-like protein; Provisional; Region: PTZ00411 454169000144 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 454169000145 active site 454169000146 dimer interface [polypeptide binding]; other site 454169000147 catalytic residue [active] 454169000148 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 454169000149 MPT binding site; other site 454169000150 trimer interface [polypeptide binding]; other site 454169000151 hypothetical protein; Provisional; Region: PRK10659 454169000152 hypothetical protein; Provisional; Region: PRK10236 454169000153 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 454169000154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 454169000155 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 454169000156 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 454169000157 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454169000158 nucleotide binding site [chemical binding]; other site 454169000159 chaperone protein DnaJ; Provisional; Region: PRK10767 454169000160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 454169000161 HSP70 interaction site [polypeptide binding]; other site 454169000162 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 454169000163 substrate binding site [polypeptide binding]; other site 454169000164 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 454169000165 Zn binding sites [ion binding]; other site 454169000166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 454169000167 dimer interface [polypeptide binding]; other site 454169000168 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169000169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169000170 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 454169000171 substrate binding pocket [chemical binding]; other site 454169000172 dimerization interface [polypeptide binding]; other site 454169000173 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 454169000174 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 454169000175 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 454169000176 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 454169000177 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 454169000178 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 454169000179 active site 454169000180 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 454169000181 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 454169000182 aromatic chitin/cellulose binding site residues [chemical binding]; other site 454169000183 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 454169000184 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 454169000185 Helix-turn-helix domain; Region: HTH_36; pfam13730 454169000186 Transposase domain (DUF772); Region: DUF772; pfam05598 454169000187 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169000188 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169000189 fimbrial protein BcfA; Provisional; Region: PRK15187 454169000190 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 454169000191 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169000192 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169000193 outer membrane usher protein; Provisional; Region: PRK15193 454169000194 PapC N-terminal domain; Region: PapC_N; pfam13954 454169000195 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169000196 PapC C-terminal domain; Region: PapC_C; pfam13953 454169000197 fimbrial protein BcfD; Provisional; Region: PRK15189 454169000198 fimbrial protein BcfE; Provisional; Region: PRK15190 454169000199 fimbrial protein BcfF; Provisional; Region: PRK15191 454169000200 fimbrial chaperone BcfG; Provisional; Region: PRK15192 454169000201 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169000202 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169000203 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 454169000204 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454169000205 catalytic residues [active] 454169000206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 454169000207 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 454169000208 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454169000209 Sulfatase; Region: Sulfatase; pfam00884 454169000210 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454169000211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169000212 FeS/SAM binding site; other site 454169000213 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454169000214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 454169000215 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 454169000216 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 454169000217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169000218 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 454169000219 putative dimerization interface [polypeptide binding]; other site 454169000220 putative alpha-glucosidase; Provisional; Region: PRK10658 454169000221 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 454169000222 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 454169000223 putative active site [active] 454169000224 putative catalytic site [active] 454169000225 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454169000226 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 454169000227 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 454169000228 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 454169000229 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 454169000230 active site 454169000231 Riboflavin kinase; Region: Flavokinase; smart00904 454169000232 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 454169000233 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 454169000234 active site 454169000235 HIGH motif; other site 454169000236 nucleotide binding site [chemical binding]; other site 454169000237 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 454169000238 active site 454169000239 KMSKS motif; other site 454169000240 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 454169000241 tRNA binding surface [nucleotide binding]; other site 454169000242 anticodon binding site; other site 454169000243 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 454169000244 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 454169000245 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 454169000246 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454169000247 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 454169000248 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 454169000249 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 454169000250 active site 454169000251 tetramer interface [polypeptide binding]; other site 454169000252 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 454169000253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169000254 active site 454169000255 phosphorylation site [posttranslational modification] 454169000256 intermolecular recognition site; other site 454169000257 dimerization interface [polypeptide binding]; other site 454169000258 Transcriptional regulator; Region: CitT; pfam12431 454169000259 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 454169000260 PAS domain; Region: PAS; smart00091 454169000261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169000262 ATP binding site [chemical binding]; other site 454169000263 Mg2+ binding site [ion binding]; other site 454169000264 G-X-G motif; other site 454169000265 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 454169000266 oxaloacetate decarboxylase; Provisional; Region: PRK14040 454169000267 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 454169000268 active site 454169000269 catalytic residues [active] 454169000270 metal binding site [ion binding]; metal-binding site 454169000271 homodimer binding site [polypeptide binding]; other site 454169000272 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454169000273 carboxyltransferase (CT) interaction site; other site 454169000274 biotinylation site [posttranslational modification]; other site 454169000275 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 454169000276 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 454169000277 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 454169000278 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 454169000279 putative active site [active] 454169000280 (T/H)XGH motif; other site 454169000281 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 454169000282 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 454169000283 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 454169000284 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 454169000285 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 454169000286 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 454169000287 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 454169000288 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 454169000289 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 454169000290 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 454169000291 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 454169000292 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 454169000293 catalytic site [active] 454169000294 subunit interface [polypeptide binding]; other site 454169000295 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 454169000296 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 454169000297 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 454169000298 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 454169000299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 454169000300 ATP-grasp domain; Region: ATP-grasp_4; cl17255 454169000301 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 454169000302 IMP binding site; other site 454169000303 dimer interface [polypeptide binding]; other site 454169000304 interdomain contacts; other site 454169000305 partial ornithine binding site; other site 454169000306 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 454169000307 carnitine operon protein CaiE; Provisional; Region: PRK13627 454169000308 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 454169000309 putative trimer interface [polypeptide binding]; other site 454169000310 putative metal binding site [ion binding]; other site 454169000311 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 454169000312 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454169000313 substrate binding site [chemical binding]; other site 454169000314 oxyanion hole (OAH) forming residues; other site 454169000315 trimer interface [polypeptide binding]; other site 454169000316 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 454169000317 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 454169000318 acyl-activating enzyme (AAE) consensus motif; other site 454169000319 putative AMP binding site [chemical binding]; other site 454169000320 putative active site [active] 454169000321 putative CoA binding site [chemical binding]; other site 454169000322 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 454169000323 CoA-transferase family III; Region: CoA_transf_3; pfam02515 454169000324 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 454169000325 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 454169000326 active site 454169000327 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 454169000328 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 454169000329 Ligand binding site [chemical binding]; other site 454169000330 Electron transfer flavoprotein domain; Region: ETF; pfam01012 454169000331 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 454169000332 Electron transfer flavoprotein domain; Region: ETF; smart00893 454169000333 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 454169000334 putative oxidoreductase FixC; Provisional; Region: PRK10157 454169000335 ferredoxin-like protein FixX; Provisional; Region: PRK15449 454169000336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169000337 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 454169000338 putative substrate translocation pore; other site 454169000339 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454169000340 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169000341 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454169000342 Sulfatase; Region: Sulfatase; cl17466 454169000343 Sulfatase; Region: Sulfatase; cl17466 454169000344 Sulfatase; Region: Sulfatase; cl17466 454169000345 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 454169000346 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 454169000347 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 454169000348 TrkA-N domain; Region: TrkA_N; pfam02254 454169000349 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 454169000350 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 454169000351 folate binding site [chemical binding]; other site 454169000352 NADP+ binding site [chemical binding]; other site 454169000353 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 454169000354 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 454169000355 active site 454169000356 metal binding site [ion binding]; metal-binding site 454169000357 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 454169000358 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 454169000359 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 454169000360 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 454169000361 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 454169000362 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 454169000363 SurA N-terminal domain; Region: SurA_N; pfam09312 454169000364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 454169000365 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 454169000366 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 454169000367 OstA-like protein; Region: OstA; pfam03968 454169000368 Organic solvent tolerance protein; Region: OstA_C; pfam04453 454169000369 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 454169000370 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 454169000371 putative metal binding site [ion binding]; other site 454169000372 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 454169000373 HSP70 interaction site [polypeptide binding]; other site 454169000374 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 454169000375 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 454169000376 active site 454169000377 ATP-dependent helicase HepA; Validated; Region: PRK04914 454169000378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169000379 ATP binding site [chemical binding]; other site 454169000380 putative Mg++ binding site [ion binding]; other site 454169000381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169000382 nucleotide binding region [chemical binding]; other site 454169000383 ATP-binding site [chemical binding]; other site 454169000384 DNA polymerase II; Reviewed; Region: PRK05762 454169000385 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 454169000386 active site 454169000387 catalytic site [active] 454169000388 substrate binding site [chemical binding]; other site 454169000389 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 454169000390 active site 454169000391 metal-binding site 454169000392 Uncharacterized conserved protein [Function unknown]; Region: COG1434 454169000393 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454169000394 putative active site [active] 454169000395 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454169000396 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454169000397 intersubunit interface [polypeptide binding]; other site 454169000398 active site 454169000399 Zn2+ binding site [ion binding]; other site 454169000400 L-arabinose isomerase; Provisional; Region: PRK02929 454169000401 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 454169000402 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 454169000403 trimer interface [polypeptide binding]; other site 454169000404 putative substrate binding site [chemical binding]; other site 454169000405 putative metal binding site [ion binding]; other site 454169000406 ribulokinase; Provisional; Region: PRK04123 454169000407 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 454169000408 N- and C-terminal domain interface [polypeptide binding]; other site 454169000409 active site 454169000410 MgATP binding site [chemical binding]; other site 454169000411 catalytic site [active] 454169000412 metal binding site [ion binding]; metal-binding site 454169000413 carbohydrate binding site [chemical binding]; other site 454169000414 homodimer interface [polypeptide binding]; other site 454169000415 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 454169000416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454169000417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169000418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169000419 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454169000420 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 454169000421 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 454169000422 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 454169000423 Walker A/P-loop; other site 454169000424 ATP binding site [chemical binding]; other site 454169000425 Q-loop/lid; other site 454169000426 ABC transporter signature motif; other site 454169000427 Walker B; other site 454169000428 D-loop; other site 454169000429 H-loop/switch region; other site 454169000430 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 454169000431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169000432 dimer interface [polypeptide binding]; other site 454169000433 conserved gate region; other site 454169000434 putative PBP binding loops; other site 454169000435 ABC-ATPase subunit interface; other site 454169000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169000437 dimer interface [polypeptide binding]; other site 454169000438 conserved gate region; other site 454169000439 putative PBP binding loops; other site 454169000440 ABC-ATPase subunit interface; other site 454169000441 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 454169000442 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 454169000443 transcriptional regulator SgrR; Provisional; Region: PRK13626 454169000444 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454169000445 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 454169000446 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 454169000447 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 454169000448 substrate binding site [chemical binding]; other site 454169000449 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 454169000450 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 454169000451 substrate binding site [chemical binding]; other site 454169000452 ligand binding site [chemical binding]; other site 454169000453 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 454169000454 tartrate dehydrogenase; Region: TTC; TIGR02089 454169000455 2-isopropylmalate synthase; Validated; Region: PRK00915 454169000456 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 454169000457 active site 454169000458 catalytic residues [active] 454169000459 metal binding site [ion binding]; metal-binding site 454169000460 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 454169000461 Leucine operon leader 454169000462 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 454169000463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169000464 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 454169000465 putative substrate binding pocket [chemical binding]; other site 454169000466 putative dimerization interface [polypeptide binding]; other site 454169000467 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 454169000468 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454169000469 PYR/PP interface [polypeptide binding]; other site 454169000470 dimer interface [polypeptide binding]; other site 454169000471 TPP binding site [chemical binding]; other site 454169000472 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454169000473 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 454169000474 TPP-binding site [chemical binding]; other site 454169000475 dimer interface [polypeptide binding]; other site 454169000476 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 454169000477 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 454169000478 putative valine binding site [chemical binding]; other site 454169000479 dimer interface [polypeptide binding]; other site 454169000480 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 454169000481 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 454169000482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169000483 DNA binding site [nucleotide binding] 454169000484 domain linker motif; other site 454169000485 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 454169000486 dimerization interface [polypeptide binding]; other site 454169000487 ligand binding site [chemical binding]; other site 454169000488 mraZ protein; Region: TIGR00242 454169000489 MraZ protein; Region: MraZ; pfam02381 454169000490 MraZ protein; Region: MraZ; pfam02381 454169000491 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 454169000492 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 454169000493 cell division protein FtsL; Provisional; Region: PRK10772 454169000494 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 454169000495 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454169000496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454169000497 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 454169000498 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454169000499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454169000500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454169000501 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 454169000502 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454169000503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454169000504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454169000505 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 454169000506 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 454169000507 Mg++ binding site [ion binding]; other site 454169000508 putative catalytic motif [active] 454169000509 putative substrate binding site [chemical binding]; other site 454169000510 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 454169000511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454169000512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454169000513 cell division protein FtsW; Provisional; Region: PRK10774 454169000514 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 454169000515 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 454169000516 active site 454169000517 homodimer interface [polypeptide binding]; other site 454169000518 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 454169000519 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454169000520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454169000521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454169000522 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 454169000523 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 454169000524 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 454169000525 cell division protein FtsQ; Provisional; Region: PRK10775 454169000526 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 454169000527 Cell division protein FtsQ; Region: FtsQ; pfam03799 454169000528 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 454169000529 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169000530 Cell division protein FtsA; Region: FtsA; pfam14450 454169000531 cell division protein FtsZ; Validated; Region: PRK09330 454169000532 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 454169000533 nucleotide binding site [chemical binding]; other site 454169000534 SulA interaction site; other site 454169000535 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 454169000536 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 454169000537 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 454169000538 SecA regulator SecM; Provisional; Region: PRK02943 454169000539 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 454169000540 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 454169000541 SEC-C motif; Region: SEC-C; pfam02810 454169000542 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 454169000543 active site 454169000544 8-oxo-dGMP binding site [chemical binding]; other site 454169000545 nudix motif; other site 454169000546 metal binding site [ion binding]; metal-binding site 454169000547 DNA gyrase inhibitor; Reviewed; Region: PRK00418 454169000548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 454169000549 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 454169000550 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 454169000551 CoA-binding site [chemical binding]; other site 454169000552 ATP-binding [chemical binding]; other site 454169000553 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 454169000554 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 454169000555 active site 454169000556 type IV pilin biogenesis protein; Provisional; Region: PRK10573 454169000557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 454169000558 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 454169000559 hypothetical protein; Provisional; Region: PRK10436 454169000560 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 454169000561 Walker A motif; other site 454169000562 ATP binding site [chemical binding]; other site 454169000563 Walker B motif; other site 454169000564 putative major pilin subunit; Provisional; Region: PRK10574 454169000565 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 454169000566 Pilin (bacterial filament); Region: Pilin; pfam00114 454169000567 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 454169000568 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 454169000569 dimerization interface [polypeptide binding]; other site 454169000570 active site 454169000571 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 454169000572 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 454169000573 amidase catalytic site [active] 454169000574 Zn binding residues [ion binding]; other site 454169000575 substrate binding site [chemical binding]; other site 454169000576 regulatory protein AmpE; Provisional; Region: PRK10987 454169000577 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 454169000578 active site 454169000579 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454169000580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169000581 putative substrate translocation pore; other site 454169000582 aromatic amino acid transporter; Provisional; Region: PRK10238 454169000583 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 454169000584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169000585 DNA-binding site [nucleotide binding]; DNA binding site 454169000586 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454169000587 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 454169000588 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 454169000589 dimer interface [polypeptide binding]; other site 454169000590 TPP-binding site [chemical binding]; other site 454169000591 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 454169000592 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454169000593 E3 interaction surface; other site 454169000594 lipoyl attachment site [posttranslational modification]; other site 454169000595 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454169000596 E3 interaction surface; other site 454169000597 lipoyl attachment site [posttranslational modification]; other site 454169000598 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454169000599 E3 interaction surface; other site 454169000600 lipoyl attachment site [posttranslational modification]; other site 454169000601 e3 binding domain; Region: E3_binding; pfam02817 454169000602 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 454169000603 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 454169000604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454169000605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169000606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454169000607 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 454169000608 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 454169000609 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 454169000610 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 454169000611 substrate binding site [chemical binding]; other site 454169000612 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 454169000613 substrate binding site [chemical binding]; other site 454169000614 ligand binding site [chemical binding]; other site 454169000615 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 454169000616 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 454169000617 aconitate hydratase 2; Provisional; Region: PLN00094 454169000618 putative inner membrane protein; Provisional; Region: PRK09823 454169000619 Low molecular weight phosphatase family; Region: LMWPc; cl00105 454169000620 active site 454169000621 hypothetical protein; Provisional; Region: PRK05248 454169000622 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 454169000623 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 454169000624 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 454169000625 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169000626 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169000627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169000628 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 454169000629 spermidine synthase; Provisional; Region: PRK00811 454169000630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169000631 S-adenosylmethionine binding site [chemical binding]; other site 454169000632 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 454169000633 multicopper oxidase; Provisional; Region: PRK10965 454169000634 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 454169000635 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 454169000636 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 454169000637 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 454169000638 Trp docking motif [polypeptide binding]; other site 454169000639 putative active site [active] 454169000640 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 454169000641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169000642 active site 454169000643 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 454169000644 active site clefts [active] 454169000645 zinc binding site [ion binding]; other site 454169000646 dimer interface [polypeptide binding]; other site 454169000647 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 454169000648 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454169000649 Walker A/P-loop; other site 454169000650 ATP binding site [chemical binding]; other site 454169000651 Q-loop/lid; other site 454169000652 ABC transporter signature motif; other site 454169000653 Walker B; other site 454169000654 D-loop; other site 454169000655 H-loop/switch region; other site 454169000656 inner membrane transport permease; Provisional; Region: PRK15066 454169000657 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454169000658 putative fimbrial protein StiH; Provisional; Region: PRK15297 454169000659 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 454169000660 PapC N-terminal domain; Region: PapC_N; pfam13954 454169000661 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169000662 PapC C-terminal domain; Region: PapC_C; pfam13953 454169000663 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 454169000664 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169000665 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169000666 fimbrial protein StiA; Provisional; Region: PRK15300 454169000667 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454169000668 active pocket/dimerization site; other site 454169000669 active site 454169000670 phosphorylation site [posttranslational modification] 454169000671 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 454169000672 putative active site [active] 454169000673 putative metal binding site [ion binding]; other site 454169000674 putative fimbrial protein StkG; Provisional; Region: PRK15305 454169000675 putative fimbrial protein StaF; Provisional; Region: PRK15262 454169000676 putative fimbrial protein StaE; Provisional; Region: PRK15263 454169000677 putative fimbrial protein StkD; Provisional; Region: PRK15306 454169000678 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 454169000679 PapC N-terminal domain; Region: PapC_N; pfam13954 454169000680 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169000681 PapC C-terminal domain; Region: PapC_C; pfam13953 454169000682 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 454169000683 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169000684 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169000685 major fimbrial protein StkA; Provisional; Region: PRK15307 454169000686 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 454169000687 tetramerization interface [polypeptide binding]; other site 454169000688 active site 454169000689 Pantoate-beta-alanine ligase; Region: PanC; cd00560 454169000690 pantoate--beta-alanine ligase; Region: panC; TIGR00018 454169000691 active site 454169000692 ATP-binding site [chemical binding]; other site 454169000693 pantoate-binding site; other site 454169000694 HXXH motif; other site 454169000695 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 454169000696 oligomerization interface [polypeptide binding]; other site 454169000697 active site 454169000698 metal binding site [ion binding]; metal-binding site 454169000699 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 454169000700 catalytic center binding site [active] 454169000701 ATP binding site [chemical binding]; other site 454169000702 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 454169000703 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 454169000704 active site 454169000705 NTP binding site [chemical binding]; other site 454169000706 metal binding triad [ion binding]; metal-binding site 454169000707 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 454169000708 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 454169000709 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 454169000710 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 454169000711 active site 454169000712 nucleotide binding site [chemical binding]; other site 454169000713 HIGH motif; other site 454169000714 KMSKS motif; other site 454169000715 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 454169000716 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 454169000717 2'-5' RNA ligase; Provisional; Region: PRK15124 454169000718 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 454169000719 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 454169000720 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 454169000721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169000722 ATP binding site [chemical binding]; other site 454169000723 putative Mg++ binding site [ion binding]; other site 454169000724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169000725 nucleotide binding region [chemical binding]; other site 454169000726 ATP-binding site [chemical binding]; other site 454169000727 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 454169000728 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 454169000729 Transglycosylase; Region: Transgly; pfam00912 454169000730 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 454169000731 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 454169000732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169000733 N-terminal plug; other site 454169000734 ligand-binding site [chemical binding]; other site 454169000735 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 454169000736 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454169000737 Walker A/P-loop; other site 454169000738 ATP binding site [chemical binding]; other site 454169000739 Q-loop/lid; other site 454169000740 ABC transporter signature motif; other site 454169000741 Walker B; other site 454169000742 D-loop; other site 454169000743 H-loop/switch region; other site 454169000744 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 454169000745 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 454169000746 siderophore binding site; other site 454169000747 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454169000748 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169000749 ABC-ATPase subunit interface; other site 454169000750 dimer interface [polypeptide binding]; other site 454169000751 putative PBP binding regions; other site 454169000752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169000753 ABC-ATPase subunit interface; other site 454169000754 dimer interface [polypeptide binding]; other site 454169000755 putative PBP binding regions; other site 454169000756 putative fimbrial subunit StfA; Provisional; Region: PRK15283 454169000757 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 454169000758 PapC N-terminal domain; Region: PapC_N; pfam13954 454169000759 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169000760 PapC C-terminal domain; Region: PapC_C; pfam13953 454169000761 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 454169000762 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169000763 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169000764 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 454169000765 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 454169000766 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 454169000767 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 454169000768 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 454169000769 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454169000770 inhibitor-cofactor binding pocket; inhibition site 454169000771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169000772 catalytic residue [active] 454169000773 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 454169000774 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 454169000775 Cl- selectivity filter; other site 454169000776 Cl- binding residues [ion binding]; other site 454169000777 pore gating glutamate residue; other site 454169000778 dimer interface [polypeptide binding]; other site 454169000779 H+/Cl- coupling transport residue; other site 454169000780 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 454169000781 hypothetical protein; Provisional; Region: PRK10578 454169000782 UPF0126 domain; Region: UPF0126; pfam03458 454169000783 UPF0126 domain; Region: UPF0126; pfam03458 454169000784 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 454169000785 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 454169000786 cobalamin binding residues [chemical binding]; other site 454169000787 putative BtuC binding residues; other site 454169000788 dimer interface [polypeptide binding]; other site 454169000789 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 454169000790 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 454169000791 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 454169000792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454169000793 Zn2+ binding site [ion binding]; other site 454169000794 Mg2+ binding site [ion binding]; other site 454169000795 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 454169000796 serine endoprotease; Provisional; Region: PRK10942 454169000797 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 454169000798 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454169000799 protein binding site [polypeptide binding]; other site 454169000800 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454169000801 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 454169000802 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 454169000803 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 454169000804 hypothetical protein; Provisional; Region: PRK13677 454169000805 shikimate transporter; Provisional; Region: PRK09952 454169000806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169000807 putative substrate translocation pore; other site 454169000808 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 454169000809 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 454169000810 trimer interface [polypeptide binding]; other site 454169000811 active site 454169000812 substrate binding site [chemical binding]; other site 454169000813 CoA binding site [chemical binding]; other site 454169000814 PII uridylyl-transferase; Provisional; Region: PRK05007 454169000815 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 454169000816 metal binding triad; other site 454169000817 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 454169000818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454169000819 Zn2+ binding site [ion binding]; other site 454169000820 Mg2+ binding site [ion binding]; other site 454169000821 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 454169000822 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 454169000823 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 454169000824 active site 454169000825 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 454169000826 rRNA interaction site [nucleotide binding]; other site 454169000827 S8 interaction site; other site 454169000828 putative laminin-1 binding site; other site 454169000829 elongation factor Ts; Provisional; Region: tsf; PRK09377 454169000830 UBA/TS-N domain; Region: UBA; pfam00627 454169000831 Elongation factor TS; Region: EF_TS; pfam00889 454169000832 Elongation factor TS; Region: EF_TS; pfam00889 454169000833 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 454169000834 putative nucleotide binding site [chemical binding]; other site 454169000835 uridine monophosphate binding site [chemical binding]; other site 454169000836 homohexameric interface [polypeptide binding]; other site 454169000837 ribosome recycling factor; Reviewed; Region: frr; PRK00083 454169000838 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 454169000839 hinge region; other site 454169000840 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 454169000841 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 454169000842 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 454169000843 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 454169000844 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 454169000845 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 454169000846 catalytic residue [active] 454169000847 putative FPP diphosphate binding site; other site 454169000848 putative FPP binding hydrophobic cleft; other site 454169000849 dimer interface [polypeptide binding]; other site 454169000850 putative IPP diphosphate binding site; other site 454169000851 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 454169000852 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 454169000853 zinc metallopeptidase RseP; Provisional; Region: PRK10779 454169000854 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 454169000855 active site 454169000856 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 454169000857 protein binding site [polypeptide binding]; other site 454169000858 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 454169000859 protein binding site [polypeptide binding]; other site 454169000860 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 454169000861 putative substrate binding region [chemical binding]; other site 454169000862 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 454169000863 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454169000864 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454169000865 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454169000866 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454169000867 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454169000868 Surface antigen; Region: Bac_surface_Ag; pfam01103 454169000869 periplasmic chaperone; Provisional; Region: PRK10780 454169000870 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 454169000871 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 454169000872 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 454169000873 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 454169000874 trimer interface [polypeptide binding]; other site 454169000875 active site 454169000876 UDP-GlcNAc binding site [chemical binding]; other site 454169000877 lipid binding site [chemical binding]; lipid-binding site 454169000878 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 454169000879 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 454169000880 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 454169000881 active site 454169000882 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 454169000883 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 454169000884 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 454169000885 RNA/DNA hybrid binding site [nucleotide binding]; other site 454169000886 active site 454169000887 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 454169000888 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 454169000889 putative active site [active] 454169000890 putative PHP Thumb interface [polypeptide binding]; other site 454169000891 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 454169000892 generic binding surface II; other site 454169000893 generic binding surface I; other site 454169000894 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 454169000895 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 454169000896 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 454169000897 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 454169000898 putative sugar binding site [chemical binding]; other site 454169000899 catalytic residues [active] 454169000900 PKD domain; Region: PKD; pfam00801 454169000901 lysine decarboxylase LdcC; Provisional; Region: PRK15399 454169000902 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454169000903 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454169000904 homodimer interface [polypeptide binding]; other site 454169000905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169000906 catalytic residue [active] 454169000907 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454169000908 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 454169000909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454169000910 putative metal binding site [ion binding]; other site 454169000911 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 454169000912 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 454169000913 Ligand Binding Site [chemical binding]; other site 454169000914 TilS substrate binding domain; Region: TilS; pfam09179 454169000915 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 454169000916 Rho-binding antiterminator; Provisional; Region: PRK11625 454169000917 hypothetical protein; Provisional; Region: PRK04964 454169000918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 454169000919 hypothetical protein; Provisional; Region: PRK09256 454169000920 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 454169000921 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 454169000922 NlpE N-terminal domain; Region: NlpE; pfam04170 454169000923 prolyl-tRNA synthetase; Provisional; Region: PRK09194 454169000924 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 454169000925 dimer interface [polypeptide binding]; other site 454169000926 motif 1; other site 454169000927 active site 454169000928 motif 2; other site 454169000929 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 454169000930 putative deacylase active site [active] 454169000931 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 454169000932 active site 454169000933 motif 3; other site 454169000934 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 454169000935 anticodon binding site; other site 454169000936 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 454169000937 homodimer interaction site [polypeptide binding]; other site 454169000938 cofactor binding site; other site 454169000939 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 454169000940 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 454169000941 lipoprotein, YaeC family; Region: TIGR00363 454169000942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169000943 dimer interface [polypeptide binding]; other site 454169000944 conserved gate region; other site 454169000945 ABC-ATPase subunit interface; other site 454169000946 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 454169000947 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 454169000948 Walker A/P-loop; other site 454169000949 ATP binding site [chemical binding]; other site 454169000950 Q-loop/lid; other site 454169000951 ABC transporter signature motif; other site 454169000952 Walker B; other site 454169000953 D-loop; other site 454169000954 H-loop/switch region; other site 454169000955 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 454169000956 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 454169000957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169000958 active site 454169000959 motif I; other site 454169000960 motif II; other site 454169000961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169000962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169000963 active site 454169000964 catalytic tetrad [active] 454169000965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169000966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169000967 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 454169000968 putative effector binding pocket; other site 454169000969 dimerization interface [polypeptide binding]; other site 454169000970 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454169000971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169000972 putative substrate translocation pore; other site 454169000973 hypothetical protein; Provisional; Region: PRK05421 454169000974 putative catalytic site [active] 454169000975 putative metal binding site [ion binding]; other site 454169000976 putative phosphate binding site [ion binding]; other site 454169000977 putative catalytic site [active] 454169000978 putative phosphate binding site [ion binding]; other site 454169000979 putative metal binding site [ion binding]; other site 454169000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169000981 S-adenosylmethionine binding site [chemical binding]; other site 454169000982 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 454169000983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169000984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169000985 catalytic residue [active] 454169000986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169000987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169000988 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 454169000989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169000990 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 454169000991 RNA/DNA hybrid binding site [nucleotide binding]; other site 454169000992 active site 454169000993 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 454169000994 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 454169000995 active site 454169000996 catalytic site [active] 454169000997 substrate binding site [chemical binding]; other site 454169000998 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 454169000999 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 454169001000 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 454169001001 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 454169001002 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 454169001003 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 454169001004 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 454169001005 ImpE protein; Region: ImpE; pfam07024 454169001006 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 454169001007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001008 Walker A motif; other site 454169001009 ATP binding site [chemical binding]; other site 454169001010 Walker B motif; other site 454169001011 arginine finger; other site 454169001012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001013 Walker A motif; other site 454169001014 ATP binding site [chemical binding]; other site 454169001015 Walker B motif; other site 454169001016 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 454169001017 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 454169001018 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 454169001019 Protein of unknown function (DUF877); Region: DUF877; pfam05943 454169001020 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 454169001021 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 454169001022 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 454169001023 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 454169001024 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 454169001025 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 454169001026 hypothetical protein; Provisional; Region: PRK08126 454169001027 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 454169001028 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454169001029 ligand binding site [chemical binding]; other site 454169001030 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 454169001031 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 454169001032 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 454169001033 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 454169001034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 454169001035 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 454169001036 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 454169001037 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 454169001038 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 454169001039 PAAR motif; Region: PAAR_motif; pfam05488 454169001040 RHS Repeat; Region: RHS_repeat; cl11982 454169001041 RHS Repeat; Region: RHS_repeat; cl11982 454169001042 RHS Repeat; Region: RHS_repeat; cl11982 454169001043 RHS Repeat; Region: RHS_repeat; pfam05593 454169001044 RHS Repeat; Region: RHS_repeat; pfam05593 454169001045 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 454169001046 RHS Repeat; Region: RHS_repeat; pfam05593 454169001047 RHS Repeat; Region: RHS_repeat; pfam05593 454169001048 RHS Repeat; Region: RHS_repeat; pfam05593 454169001049 RHS Repeat; Region: RHS_repeat; pfam05593 454169001050 RHS Repeat; Region: RHS_repeat; pfam05593 454169001051 RHS protein; Region: RHS; pfam03527 454169001052 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 454169001053 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 454169001054 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 454169001055 putative fimbrial protein TcfA; Provisional; Region: PRK15308 454169001056 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 454169001057 putative fimbrial subunit TcfB; Provisional; Region: PRK15309 454169001058 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 454169001059 putative fimbrial protein TcfD; Provisional; Region: PRK15311 454169001060 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 454169001061 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 454169001062 AsnC family; Region: AsnC_trans_reg; pfam01037 454169001063 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 454169001064 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454169001065 dimer interface [polypeptide binding]; other site 454169001066 C-N hydrolase family amidase; Provisional; Region: PRK10438 454169001067 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 454169001068 putative active site [active] 454169001069 catalytic triad [active] 454169001070 dimer interface [polypeptide binding]; other site 454169001071 multimer interface [polypeptide binding]; other site 454169001072 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 454169001073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 454169001074 active site 454169001075 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 454169001076 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 454169001077 dimer interface [polypeptide binding]; other site 454169001078 active site 454169001079 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 454169001080 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 454169001081 putative active site [active] 454169001082 putative dimer interface [polypeptide binding]; other site 454169001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 454169001084 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169001085 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 454169001086 active site 454169001087 DNA polymerase IV; Validated; Region: PRK02406 454169001088 DNA binding site [nucleotide binding] 454169001089 hypothetical protein; Reviewed; Region: PRK09588 454169001090 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 454169001091 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 454169001092 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 454169001093 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 454169001094 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 454169001095 metal binding site [ion binding]; metal-binding site 454169001096 dimer interface [polypeptide binding]; other site 454169001097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169001098 active site 454169001099 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 454169001100 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 454169001101 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169001102 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169001103 trimer interface [polypeptide binding]; other site 454169001104 eyelet of channel; other site 454169001105 gamma-glutamyl kinase; Provisional; Region: PRK05429 454169001106 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 454169001107 nucleotide binding site [chemical binding]; other site 454169001108 homotetrameric interface [polypeptide binding]; other site 454169001109 putative phosphate binding site [ion binding]; other site 454169001110 putative allosteric binding site; other site 454169001111 PUA domain; Region: PUA; pfam01472 454169001112 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 454169001113 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 454169001114 putative catalytic cysteine [active] 454169001115 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 454169001116 Int/Topo IB signature motif; other site 454169001117 Protein of unknown function (DUF550); Region: DUF550; pfam04447 454169001118 Protein of unknown function (DUF551); Region: DUF551; pfam04448 454169001119 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 454169001120 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 454169001121 ERF superfamily; Region: ERF; pfam04404 454169001122 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 454169001123 hypothetical protein; Region: PHA01516 454169001124 Antirestriction protein Ral; Region: Ral; pfam11058 454169001125 Superinfection exclusion protein B; Region: SieB; pfam14163 454169001126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169001127 sequence-specific DNA binding site [nucleotide binding]; other site 454169001128 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 454169001129 salt bridge; other site 454169001130 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 454169001131 Catalytic site [active] 454169001132 Bacteriophage CII protein; Region: Phage_CII; pfam05269 454169001133 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 454169001134 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 454169001135 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 454169001136 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 454169001137 Walker A motif; other site 454169001138 ATP binding site [chemical binding]; other site 454169001139 Walker B motif; other site 454169001140 DNA binding loops [nucleotide binding] 454169001141 hypothetical protein; Region: PHA01519 454169001142 NinF protein; Region: NinF; pfam05810 454169001143 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 454169001144 Phage NinH protein; Region: Phage_NinH; pfam06322 454169001145 Antitermination protein; Region: Antiterm; pfam03589 454169001146 Antitermination protein; Region: Antiterm; pfam03589 454169001147 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 454169001148 catalytic residues [active] 454169001149 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 454169001150 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 454169001151 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 454169001152 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 454169001153 hypothetical protein; Region: PHA00781 454169001154 Terminase-like family; Region: Terminase_6; pfam03237 454169001155 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 454169001156 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 454169001157 coat protein; Region: PHA01511 454169001158 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 454169001159 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 454169001160 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 454169001161 Protein of unknown function (DUF812); Region: DUF812; pfam05667 454169001162 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 454169001163 Arc-like DNA binding domain; Region: Arc; pfam03869 454169001164 Head binding; Region: Head_binding; pfam09008 454169001165 Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251 454169001166 O-antigen conversion protein C; Region: PHA01514 454169001167 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454169001168 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454169001169 Ligand binding site; other site 454169001170 Putative Catalytic site; other site 454169001171 DXD motif; other site 454169001172 Predicted membrane protein [Function unknown]; Region: COG2246 454169001173 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 454169001174 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454169001175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001176 putative substrate translocation pore; other site 454169001177 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 454169001178 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 454169001179 substrate binding site [chemical binding]; other site 454169001180 ligand binding site [chemical binding]; other site 454169001181 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 454169001182 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 454169001183 hypothetical protein; Provisional; Region: PRK14812 454169001184 substrate binding site [chemical binding]; other site 454169001185 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 454169001186 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 454169001187 transcriptional activator TtdR; Provisional; Region: PRK09801 454169001188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169001189 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 454169001190 putative effector binding pocket; other site 454169001191 putative dimerization interface [polypeptide binding]; other site 454169001192 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 454169001193 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169001194 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169001195 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 454169001196 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 454169001197 PapC N-terminal domain; Region: PapC_N; pfam13954 454169001198 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169001199 PapC C-terminal domain; Region: PapC_C; pfam13953 454169001200 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 454169001201 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169001202 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169001203 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 454169001204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 454169001205 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454169001206 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169001207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 454169001208 DNA binding site [nucleotide binding] 454169001209 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 454169001210 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 454169001211 DNA binding residues [nucleotide binding] 454169001212 dimerization interface [polypeptide binding]; other site 454169001213 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 454169001214 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 454169001215 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 454169001216 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 454169001217 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169001218 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169001219 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 454169001220 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454169001221 metal-binding site [ion binding] 454169001222 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454169001223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169001224 motif II; other site 454169001225 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 454169001226 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 454169001227 DNA binding residues [nucleotide binding] 454169001228 dimer interface [polypeptide binding]; other site 454169001229 copper binding site [ion binding]; other site 454169001230 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454169001231 metal-binding site [ion binding] 454169001232 putative sialic acid transporter; Region: 2A0112; TIGR00891 454169001233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001234 putative substrate translocation pore; other site 454169001235 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 454169001236 DNA methylase; Region: N6_N4_Mtase; cl17433 454169001237 DNA methylase; Region: N6_N4_Mtase; pfam01555 454169001238 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 454169001239 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 454169001240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 454169001241 VRR-NUC domain; Region: VRR_NUC; pfam08774 454169001242 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 454169001243 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 454169001244 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 454169001245 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 454169001246 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169001247 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 454169001248 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169001249 N-terminal plug; other site 454169001250 ligand-binding site [chemical binding]; other site 454169001251 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 454169001252 hypothetical protein; Provisional; Region: PRK09929 454169001253 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 454169001254 Propionate catabolism activator; Region: PrpR_N; pfam06506 454169001255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001256 Walker A motif; other site 454169001257 ATP binding site [chemical binding]; other site 454169001258 Walker B motif; other site 454169001259 arginine finger; other site 454169001260 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454169001261 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 454169001262 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 454169001263 tetramer interface [polypeptide binding]; other site 454169001264 active site 454169001265 Mg2+/Mn2+ binding site [ion binding]; other site 454169001266 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 454169001267 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 454169001268 dimer interface [polypeptide binding]; other site 454169001269 active site 454169001270 citrylCoA binding site [chemical binding]; other site 454169001271 oxalacetate/citrate binding site [chemical binding]; other site 454169001272 coenzyme A binding site [chemical binding]; other site 454169001273 catalytic triad [active] 454169001274 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 454169001275 2-methylcitrate dehydratase; Region: prpD; TIGR02330 454169001276 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 454169001277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 454169001278 acyl-activating enzyme (AAE) consensus motif; other site 454169001279 AMP binding site [chemical binding]; other site 454169001280 active site 454169001281 CoA binding site [chemical binding]; other site 454169001282 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 454169001283 dimer interface [polypeptide binding]; other site 454169001284 active site 454169001285 Schiff base residues; other site 454169001286 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 454169001287 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 454169001288 Autotransporter beta-domain; Region: Autotransporter; pfam03797 454169001289 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 454169001290 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 454169001291 ligand binding site [chemical binding]; other site 454169001292 flexible hinge region; other site 454169001293 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 454169001294 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 454169001295 microcin B17 transporter; Reviewed; Region: PRK11098 454169001296 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 454169001297 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 454169001298 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 454169001299 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 454169001300 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 454169001301 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 454169001302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 454169001303 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 454169001304 drug efflux system protein MdtG; Provisional; Region: PRK09874 454169001305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001306 putative substrate translocation pore; other site 454169001307 anti-RssB factor; Provisional; Region: PRK10244 454169001308 hypothetical protein; Provisional; Region: PRK11505 454169001309 psiF repeat; Region: PsiF_repeat; pfam07769 454169001310 psiF repeat; Region: PsiF_repeat; pfam07769 454169001311 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 454169001312 MASE2 domain; Region: MASE2; pfam05230 454169001313 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169001314 metal binding site [ion binding]; metal-binding site 454169001315 active site 454169001316 I-site; other site 454169001317 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 454169001318 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 454169001319 hypothetical protein; Validated; Region: PRK00124 454169001320 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 454169001321 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 454169001322 ADP binding site [chemical binding]; other site 454169001323 magnesium binding site [ion binding]; other site 454169001324 putative shikimate binding site; other site 454169001325 hypothetical protein; Provisional; Region: PRK10380 454169001326 hypothetical protein; Provisional; Region: PRK10481 454169001327 hypothetical protein; Provisional; Region: PRK10579 454169001328 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 454169001329 fructokinase; Reviewed; Region: PRK09557 454169001330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169001331 nucleotide binding site [chemical binding]; other site 454169001332 MFS transport protein AraJ; Provisional; Region: PRK10091 454169001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001334 putative substrate translocation pore; other site 454169001335 exonuclease subunit SbcC; Provisional; Region: PRK10246 454169001336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169001337 Walker A/P-loop; other site 454169001338 ATP binding site [chemical binding]; other site 454169001339 Q-loop/lid; other site 454169001340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169001341 ABC transporter signature motif; other site 454169001342 Walker B; other site 454169001343 D-loop; other site 454169001344 H-loop/switch region; other site 454169001345 exonuclease subunit SbcD; Provisional; Region: PRK10966 454169001346 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 454169001347 active site 454169001348 metal binding site [ion binding]; metal-binding site 454169001349 DNA binding site [nucleotide binding] 454169001350 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 454169001351 transcriptional regulator PhoB; Provisional; Region: PRK10161 454169001352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169001353 active site 454169001354 phosphorylation site [posttranslational modification] 454169001355 intermolecular recognition site; other site 454169001356 dimerization interface [polypeptide binding]; other site 454169001357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169001358 DNA binding site [nucleotide binding] 454169001359 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 454169001360 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 454169001361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169001362 putative active site [active] 454169001363 heme pocket [chemical binding]; other site 454169001364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169001365 dimer interface [polypeptide binding]; other site 454169001366 phosphorylation site [posttranslational modification] 454169001367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169001368 ATP binding site [chemical binding]; other site 454169001369 Mg2+ binding site [ion binding]; other site 454169001370 G-X-G motif; other site 454169001371 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 454169001372 putative proline-specific permease; Provisional; Region: proY; PRK10580 454169001373 maltodextrin glucosidase; Provisional; Region: PRK10785 454169001374 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 454169001375 homodimer interface [polypeptide binding]; other site 454169001376 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 454169001377 active site 454169001378 homodimer interface [polypeptide binding]; other site 454169001379 catalytic site [active] 454169001380 peroxidase; Provisional; Region: PRK15000 454169001381 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 454169001382 dimer interface [polypeptide binding]; other site 454169001383 decamer (pentamer of dimers) interface [polypeptide binding]; other site 454169001384 catalytic triad [active] 454169001385 peroxidatic and resolving cysteines [active] 454169001386 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 454169001387 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 454169001388 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 454169001389 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 454169001390 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 454169001391 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 454169001392 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 454169001393 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 454169001394 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 454169001395 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 454169001396 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 454169001397 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 454169001398 Protein export membrane protein; Region: SecD_SecF; pfam02355 454169001399 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 454169001400 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454169001401 Predicted transcriptional regulator [Transcription]; Region: COG2378 454169001402 HTH domain; Region: HTH_11; pfam08279 454169001403 WYL domain; Region: WYL; pfam13280 454169001404 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 454169001405 active site 454169001406 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 454169001407 hypothetical protein; Provisional; Region: PRK11530 454169001408 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 454169001409 ATP cone domain; Region: ATP-cone; pfam03477 454169001410 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 454169001411 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 454169001412 catalytic motif [active] 454169001413 Zn binding site [ion binding]; other site 454169001414 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 454169001415 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 454169001416 homopentamer interface [polypeptide binding]; other site 454169001417 active site 454169001418 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 454169001419 putative RNA binding site [nucleotide binding]; other site 454169001420 thiamine monophosphate kinase; Provisional; Region: PRK05731 454169001421 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 454169001422 ATP binding site [chemical binding]; other site 454169001423 dimerization interface [polypeptide binding]; other site 454169001424 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 454169001425 tetramer interfaces [polypeptide binding]; other site 454169001426 binuclear metal-binding site [ion binding]; other site 454169001427 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169001428 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169001429 active site 454169001430 catalytic tetrad [active] 454169001431 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 454169001432 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 454169001433 TPP-binding site; other site 454169001434 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454169001435 PYR/PP interface [polypeptide binding]; other site 454169001436 dimer interface [polypeptide binding]; other site 454169001437 TPP binding site [chemical binding]; other site 454169001438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454169001439 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 454169001440 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 454169001441 substrate binding pocket [chemical binding]; other site 454169001442 chain length determination region; other site 454169001443 substrate-Mg2+ binding site; other site 454169001444 catalytic residues [active] 454169001445 aspartate-rich region 1; other site 454169001446 active site lid residues [active] 454169001447 aspartate-rich region 2; other site 454169001448 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 454169001449 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 454169001450 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 454169001451 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 454169001452 Ligand Binding Site [chemical binding]; other site 454169001453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 454169001454 active site residue [active] 454169001455 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 454169001456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169001457 dimer interface [polypeptide binding]; other site 454169001458 conserved gate region; other site 454169001459 putative PBP binding loops; other site 454169001460 ABC-ATPase subunit interface; other site 454169001461 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 454169001462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169001463 dimer interface [polypeptide binding]; other site 454169001464 conserved gate region; other site 454169001465 putative PBP binding loops; other site 454169001466 ABC-ATPase subunit interface; other site 454169001467 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 454169001468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169001469 Walker A/P-loop; other site 454169001470 ATP binding site [chemical binding]; other site 454169001471 Q-loop/lid; other site 454169001472 ABC transporter signature motif; other site 454169001473 Walker B; other site 454169001474 D-loop; other site 454169001475 H-loop/switch region; other site 454169001476 TOBE domain; Region: TOBE_2; pfam08402 454169001477 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 454169001478 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 454169001479 transcriptional regulator protein; Region: phnR; TIGR03337 454169001480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169001481 DNA-binding site [nucleotide binding]; DNA binding site 454169001482 UTRA domain; Region: UTRA; pfam07702 454169001483 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 454169001484 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169001485 catalytic residue [active] 454169001486 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 454169001487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169001488 motif II; other site 454169001489 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 454169001490 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 454169001491 conserved cys residue [active] 454169001492 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 454169001493 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 454169001494 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 454169001495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 454169001496 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 454169001497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169001499 putative substrate translocation pore; other site 454169001500 Sel1-like repeats; Region: SEL1; smart00671 454169001501 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169001502 Sel1 repeat; Region: Sel1; pfam08238 454169001503 Sel1-like repeats; Region: SEL1; smart00671 454169001504 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169001505 Sel1-like repeats; Region: SEL1; smart00671 454169001506 Sel1-like repeats; Region: SEL1; smart00671 454169001507 Sel1-like repeats; Region: SEL1; smart00671 454169001508 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 454169001509 UbiA prenyltransferase family; Region: UbiA; pfam01040 454169001510 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 454169001511 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 454169001512 Subunit I/III interface [polypeptide binding]; other site 454169001513 Subunit III/IV interface [polypeptide binding]; other site 454169001514 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 454169001515 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 454169001516 D-pathway; other site 454169001517 Putative ubiquinol binding site [chemical binding]; other site 454169001518 Low-spin heme (heme b) binding site [chemical binding]; other site 454169001519 Putative water exit pathway; other site 454169001520 Binuclear center (heme o3/CuB) [ion binding]; other site 454169001521 K-pathway; other site 454169001522 Putative proton exit pathway; other site 454169001523 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 454169001524 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 454169001525 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 454169001526 muropeptide transporter; Reviewed; Region: ampG; PRK11902 454169001527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001528 putative substrate translocation pore; other site 454169001529 hypothetical protein; Provisional; Region: PRK11627 454169001530 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 454169001531 transcriptional regulator BolA; Provisional; Region: PRK11628 454169001532 trigger factor; Provisional; Region: tig; PRK01490 454169001533 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454169001534 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 454169001535 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 454169001536 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 454169001537 oligomer interface [polypeptide binding]; other site 454169001538 active site residues [active] 454169001539 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 454169001540 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 454169001541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001542 Walker A motif; other site 454169001543 ATP binding site [chemical binding]; other site 454169001544 Walker B motif; other site 454169001545 Iron permease FTR1 family; Region: FTR1; cl00475 454169001546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 454169001547 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 454169001548 Found in ATP-dependent protease La (LON); Region: LON; smart00464 454169001549 Found in ATP-dependent protease La (LON); Region: LON; smart00464 454169001550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001551 Walker A motif; other site 454169001552 ATP binding site [chemical binding]; other site 454169001553 Walker B motif; other site 454169001554 arginine finger; other site 454169001555 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 454169001556 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454169001557 IHF dimer interface [polypeptide binding]; other site 454169001558 IHF - DNA interface [nucleotide binding]; other site 454169001559 periplasmic folding chaperone; Provisional; Region: PRK10788 454169001560 SurA N-terminal domain; Region: SurA_N_3; cl07813 454169001561 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 454169001562 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 454169001563 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 454169001564 active site 454169001565 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 454169001566 Ligand Binding Site [chemical binding]; other site 454169001567 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 454169001568 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454169001569 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 454169001570 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 454169001571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169001572 active site 454169001573 motif I; other site 454169001574 motif II; other site 454169001575 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 454169001576 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 454169001577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169001578 catalytic residue [active] 454169001579 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 454169001580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169001581 putative DNA binding site [nucleotide binding]; other site 454169001582 putative Zn2+ binding site [ion binding]; other site 454169001583 AsnC family; Region: AsnC_trans_reg; pfam01037 454169001584 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 454169001585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169001586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169001587 Walker A/P-loop; other site 454169001588 ATP binding site [chemical binding]; other site 454169001589 Q-loop/lid; other site 454169001590 ABC transporter signature motif; other site 454169001591 Walker B; other site 454169001592 D-loop; other site 454169001593 H-loop/switch region; other site 454169001594 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 454169001595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169001596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169001597 Walker A/P-loop; other site 454169001598 ATP binding site [chemical binding]; other site 454169001599 Q-loop/lid; other site 454169001600 ABC transporter signature motif; other site 454169001601 Walker B; other site 454169001602 D-loop; other site 454169001603 H-loop/switch region; other site 454169001604 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 454169001605 Nitrogen regulatory protein P-II; Region: P-II; smart00938 454169001606 ammonium transporter; Provisional; Region: PRK10666 454169001607 acyl-CoA thioesterase II; Provisional; Region: PRK10526 454169001608 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 454169001609 active site 454169001610 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 454169001611 catalytic triad [active] 454169001612 dimer interface [polypeptide binding]; other site 454169001613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 454169001614 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 454169001615 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 454169001616 DNA binding site [nucleotide binding] 454169001617 active site 454169001618 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 454169001619 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454169001620 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169001621 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 454169001622 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 454169001623 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 454169001624 maltose O-acetyltransferase; Provisional; Region: PRK10092 454169001625 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 454169001626 active site 454169001627 substrate binding site [chemical binding]; other site 454169001628 trimer interface [polypeptide binding]; other site 454169001629 CoA binding site [chemical binding]; other site 454169001630 gene expression modulator; Provisional; Region: PRK10945 454169001631 Hha toxicity attenuator; Provisional; Region: PRK10667 454169001632 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 454169001633 Protein export membrane protein; Region: SecD_SecF; cl14618 454169001634 Protein export membrane protein; Region: SecD_SecF; cl14618 454169001635 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 454169001636 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169001637 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 454169001638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169001639 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 454169001640 hypothetical protein; Provisional; Region: PRK11281 454169001641 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 454169001642 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 454169001643 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169001644 hypothetical protein; Provisional; Region: PRK11038 454169001645 primosomal replication protein N''; Provisional; Region: PRK10093 454169001646 hypothetical protein; Provisional; Region: PRK10527 454169001647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169001648 active site 454169001649 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 454169001650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001651 Walker A motif; other site 454169001652 ATP binding site [chemical binding]; other site 454169001653 Walker B motif; other site 454169001654 DNA polymerase III subunit delta'; Validated; Region: PRK08485 454169001655 arginine finger; other site 454169001656 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 454169001657 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 454169001658 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 454169001659 DnaX ribosomal frameshifting element 454169001660 hypothetical protein; Validated; Region: PRK00153 454169001661 recombination protein RecR; Reviewed; Region: recR; PRK00076 454169001662 RecR protein; Region: RecR; pfam02132 454169001663 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 454169001664 putative active site [active] 454169001665 putative metal-binding site [ion binding]; other site 454169001666 tetramer interface [polypeptide binding]; other site 454169001667 heat shock protein 90; Provisional; Region: PRK05218 454169001668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169001669 ATP binding site [chemical binding]; other site 454169001670 Mg2+ binding site [ion binding]; other site 454169001671 G-X-G motif; other site 454169001672 adenylate kinase; Reviewed; Region: adk; PRK00279 454169001673 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 454169001674 AMP-binding site [chemical binding]; other site 454169001675 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 454169001676 ferrochelatase; Reviewed; Region: hemH; PRK00035 454169001677 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 454169001678 C-terminal domain interface [polypeptide binding]; other site 454169001679 active site 454169001680 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 454169001681 active site 454169001682 N-terminal domain interface [polypeptide binding]; other site 454169001683 inosine/guanosine kinase; Provisional; Region: PRK15074 454169001684 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169001685 putative cation:proton antiport protein; Provisional; Region: PRK10669 454169001686 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 454169001687 TrkA-N domain; Region: TrkA_N; pfam02254 454169001688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169001690 putative substrate translocation pore; other site 454169001691 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 454169001692 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 454169001693 active site 454169001694 metal binding site [ion binding]; metal-binding site 454169001695 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454169001696 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 454169001697 putative deacylase active site [active] 454169001698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 454169001699 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 454169001700 copper exporting ATPase; Provisional; Region: copA; PRK10671 454169001701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454169001702 metal-binding site [ion binding] 454169001703 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454169001704 metal-binding site [ion binding] 454169001705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454169001706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169001707 motif II; other site 454169001708 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 454169001709 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 454169001710 DNA binding residues [nucleotide binding] 454169001711 dimer interface [polypeptide binding]; other site 454169001712 copper binding site [ion binding]; other site 454169001713 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 454169001714 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 454169001715 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 454169001716 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 454169001717 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 454169001718 Walker A/P-loop; other site 454169001719 ATP binding site [chemical binding]; other site 454169001720 Q-loop/lid; other site 454169001721 ABC transporter signature motif; other site 454169001722 Walker B; other site 454169001723 D-loop; other site 454169001724 H-loop/switch region; other site 454169001725 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 454169001726 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 454169001727 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 454169001728 oxidoreductase; Provisional; Region: PRK08017 454169001729 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 454169001730 NADP binding site [chemical binding]; other site 454169001731 active site 454169001732 steroid binding site; other site 454169001733 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 454169001734 active site 454169001735 catalytic triad [active] 454169001736 oxyanion hole [active] 454169001737 switch loop; other site 454169001738 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 454169001739 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 454169001740 Walker A/P-loop; other site 454169001741 ATP binding site [chemical binding]; other site 454169001742 Q-loop/lid; other site 454169001743 ABC transporter signature motif; other site 454169001744 Walker B; other site 454169001745 D-loop; other site 454169001746 H-loop/switch region; other site 454169001747 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 454169001748 FtsX-like permease family; Region: FtsX; pfam02687 454169001749 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169001750 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 454169001751 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 454169001752 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 454169001753 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 454169001754 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 454169001755 Walker A/P-loop; other site 454169001756 ATP binding site [chemical binding]; other site 454169001757 Q-loop/lid; other site 454169001758 ABC transporter signature motif; other site 454169001759 Walker B; other site 454169001760 D-loop; other site 454169001761 H-loop/switch region; other site 454169001762 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 454169001763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169001764 dimer interface [polypeptide binding]; other site 454169001765 conserved gate region; other site 454169001766 ABC-ATPase subunit interface; other site 454169001767 Predicted ATPase [General function prediction only]; Region: COG2603 454169001768 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 454169001769 active site residue [active] 454169001770 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 454169001771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169001772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169001773 dimerization interface [polypeptide binding]; other site 454169001774 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 454169001775 ureidoglycolate hydrolase; Provisional; Region: PRK03606 454169001776 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 454169001777 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454169001778 Bacterial transcriptional regulator; Region: IclR; pfam01614 454169001779 glyoxylate carboligase; Provisional; Region: PRK11269 454169001780 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454169001781 PYR/PP interface [polypeptide binding]; other site 454169001782 dimer interface [polypeptide binding]; other site 454169001783 TPP binding site [chemical binding]; other site 454169001784 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454169001785 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 454169001786 TPP-binding site [chemical binding]; other site 454169001787 hydroxypyruvate isomerase; Provisional; Region: PRK09997 454169001788 tartronate semialdehyde reductase; Provisional; Region: PRK15059 454169001789 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454169001790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169001792 putative substrate translocation pore; other site 454169001793 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 454169001794 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 454169001795 Na binding site [ion binding]; other site 454169001796 putative substrate binding site [chemical binding]; other site 454169001797 allantoinase; Provisional; Region: PRK08044 454169001798 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 454169001799 active site 454169001800 putative uracil/xanthine transporter; Provisional; Region: PRK11412 454169001801 glycerate kinase II; Provisional; Region: PRK09932 454169001802 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 454169001803 Mif2/CENP-C like; Region: Mif2; pfam11699 454169001804 Cupin domain; Region: Cupin_2; pfam07883 454169001805 allantoate amidohydrolase; Region: AllC; TIGR03176 454169001806 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 454169001807 active site 454169001808 metal binding site [ion binding]; metal-binding site 454169001809 dimer interface [polypeptide binding]; other site 454169001810 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 454169001811 membrane protein FdrA; Validated; Region: PRK06091 454169001812 CoA binding domain; Region: CoA_binding; pfam02629 454169001813 CoA-ligase; Region: Ligase_CoA; pfam00549 454169001814 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 454169001815 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 454169001816 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 454169001817 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 454169001818 putative substrate binding site [chemical binding]; other site 454169001819 nucleotide binding site [chemical binding]; other site 454169001820 nucleotide binding site [chemical binding]; other site 454169001821 homodimer interface [polypeptide binding]; other site 454169001822 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 454169001823 ATP-grasp domain; Region: ATP-grasp; pfam02222 454169001824 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 454169001825 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 454169001826 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454169001827 putative active site [active] 454169001828 putative metal binding site [ion binding]; other site 454169001829 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 454169001830 substrate binding site [chemical binding]; other site 454169001831 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 454169001832 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 454169001833 active site 454169001834 HIGH motif; other site 454169001835 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 454169001836 KMSKS motif; other site 454169001837 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 454169001838 tRNA binding surface [nucleotide binding]; other site 454169001839 anticodon binding site; other site 454169001840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 454169001841 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 454169001842 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 454169001843 ribosome-associated protein; Provisional; Region: PRK11507 454169001844 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 454169001845 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 454169001846 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 454169001847 homodimer interface [polypeptide binding]; other site 454169001848 NADP binding site [chemical binding]; other site 454169001849 substrate binding site [chemical binding]; other site 454169001850 Transposase domain (DUF772); Region: DUF772; pfam05598 454169001851 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169001852 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169001853 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 454169001854 fimbrial protein FimI; Provisional; Region: PRK15200 454169001855 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 454169001856 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169001857 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169001858 outer membrane usher protein FimD; Provisional; Region: PRK15198 454169001859 PapC N-terminal domain; Region: PapC_N; pfam13954 454169001860 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169001861 PapC C-terminal domain; Region: PapC_C; pfam13953 454169001862 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 454169001863 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 454169001864 transcriptional regulator FimZ; Provisional; Region: PRK09935 454169001865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169001866 active site 454169001867 phosphorylation site [posttranslational modification] 454169001868 intermolecular recognition site; other site 454169001869 dimerization interface [polypeptide binding]; other site 454169001870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169001871 DNA binding residues [nucleotide binding] 454169001872 dimerization interface [polypeptide binding]; other site 454169001873 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 454169001874 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169001875 DNA binding residues [nucleotide binding] 454169001876 dimerization interface [polypeptide binding]; other site 454169001877 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454169001878 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454169001879 Ligand binding site; other site 454169001880 Putative Catalytic site; other site 454169001881 DXD motif; other site 454169001882 Predicted membrane protein [Function unknown]; Region: COG2246 454169001883 GtrA-like protein; Region: GtrA; pfam04138 454169001884 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 454169001885 Cupin; Region: Cupin_6; pfam12852 454169001886 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 454169001887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169001888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169001889 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 454169001890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169001891 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454169001892 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169001893 Predicted membrane protein [Function unknown]; Region: COG3059 454169001894 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 454169001895 phenylalanine transporter; Provisional; Region: PRK10249 454169001896 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 454169001897 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169001898 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 454169001899 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 454169001900 active site 454169001901 oxyanion hole [active] 454169001902 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 454169001903 catalytic triad [active] 454169001904 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 454169001905 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 454169001906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169001907 ATP binding site [chemical binding]; other site 454169001908 Walker B motif; other site 454169001909 arginine finger; other site 454169001910 Transcriptional antiterminator [Transcription]; Region: COG3933 454169001911 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454169001912 active pocket/dimerization site; other site 454169001913 active site 454169001914 phosphorylation site [posttranslational modification] 454169001915 PRD domain; Region: PRD; pfam00874 454169001916 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 454169001917 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 454169001918 putative active site [active] 454169001919 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454169001920 dimer interface [polypeptide binding]; other site 454169001921 active site 454169001922 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 454169001923 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 454169001924 dimer interface [polypeptide binding]; other site 454169001925 active site 454169001926 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454169001927 dimer interface [polypeptide binding]; other site 454169001928 active site 454169001929 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 454169001930 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 454169001931 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 454169001932 active site 454169001933 phosphorylation site [posttranslational modification] 454169001934 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454169001935 active pocket/dimerization site; other site 454169001936 active site 454169001937 phosphorylation site [posttranslational modification] 454169001938 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 454169001939 dimer interface [polypeptide binding]; other site 454169001940 FMN binding site [chemical binding]; other site 454169001941 hypothetical protein; Provisional; Region: PRK10250 454169001942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454169001943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169001944 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 454169001945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169001946 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 454169001947 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 454169001948 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 454169001949 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 454169001950 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 454169001951 outer membrane receptor FepA; Provisional; Region: PRK13524 454169001952 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169001953 N-terminal plug; other site 454169001954 ligand-binding site [chemical binding]; other site 454169001955 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 454169001956 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 454169001957 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 454169001958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 454169001959 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 454169001960 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 454169001961 acyl-activating enzyme (AAE) consensus motif; other site 454169001962 AMP binding site [chemical binding]; other site 454169001963 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 454169001964 LPS O-antigen length regulator; Provisional; Region: PRK10381 454169001965 Chain length determinant protein; Region: Wzz; pfam02706 454169001966 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 454169001967 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454169001968 Walker A/P-loop; other site 454169001969 ATP binding site [chemical binding]; other site 454169001970 Q-loop/lid; other site 454169001971 ABC transporter signature motif; other site 454169001972 Walker B; other site 454169001973 D-loop; other site 454169001974 H-loop/switch region; other site 454169001975 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 454169001976 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169001977 ABC-ATPase subunit interface; other site 454169001978 dimer interface [polypeptide binding]; other site 454169001979 putative PBP binding regions; other site 454169001980 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454169001981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169001982 ABC-ATPase subunit interface; other site 454169001983 dimer interface [polypeptide binding]; other site 454169001984 putative PBP binding regions; other site 454169001985 enterobactin exporter EntS; Provisional; Region: PRK10489 454169001986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169001987 putative substrate translocation pore; other site 454169001988 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 454169001989 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 454169001990 siderophore binding site; other site 454169001991 isochorismate synthase EntC; Provisional; Region: PRK15016 454169001992 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 454169001993 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 454169001994 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 454169001995 acyl-activating enzyme (AAE) consensus motif; other site 454169001996 active site 454169001997 AMP binding site [chemical binding]; other site 454169001998 substrate binding site [chemical binding]; other site 454169001999 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 454169002000 hydrophobic substrate binding pocket; other site 454169002001 Isochorismatase family; Region: Isochorismatase; pfam00857 454169002002 active site 454169002003 conserved cis-peptide bond; other site 454169002004 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 454169002005 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 454169002006 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 454169002007 putative NAD(P) binding site [chemical binding]; other site 454169002008 active site 454169002009 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 454169002010 CoenzymeA binding site [chemical binding]; other site 454169002011 subunit interaction site [polypeptide binding]; other site 454169002012 PHB binding site; other site 454169002013 carbon starvation protein A; Provisional; Region: PRK15015 454169002014 Carbon starvation protein CstA; Region: CstA; pfam02554 454169002015 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 454169002016 Uncharacterized small protein [Function unknown]; Region: COG2879 454169002017 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 454169002018 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 454169002019 putative active site [active] 454169002020 metal binding site [ion binding]; metal-binding site 454169002021 methionine aminotransferase; Validated; Region: PRK09082 454169002022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169002023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169002024 homodimer interface [polypeptide binding]; other site 454169002025 catalytic residue [active] 454169002026 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 454169002027 ParB-like nuclease domain; Region: ParBc; pfam02195 454169002028 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 454169002029 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 454169002030 Active Sites [active] 454169002031 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 454169002032 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 454169002033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169002034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169002035 dimerization interface [polypeptide binding]; other site 454169002036 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 454169002037 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 454169002038 dimerization domain [polypeptide binding]; other site 454169002039 dimer interface [polypeptide binding]; other site 454169002040 catalytic residues [active] 454169002041 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 454169002042 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 454169002043 dimer interface [polypeptide binding]; other site 454169002044 decamer (pentamer of dimers) interface [polypeptide binding]; other site 454169002045 catalytic triad [active] 454169002046 peroxidatic and resolving cysteines [active] 454169002047 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 454169002048 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 454169002049 catalytic residue [active] 454169002050 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 454169002051 catalytic residues [active] 454169002052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169002053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169002054 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 454169002055 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 454169002056 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 454169002057 putative [4Fe-4S] binding site [ion binding]; other site 454169002058 putative molybdopterin cofactor binding site [chemical binding]; other site 454169002059 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 454169002060 molybdopterin cofactor binding site; other site 454169002061 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 454169002062 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 454169002063 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454169002064 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454169002065 Ligand Binding Site [chemical binding]; other site 454169002066 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 454169002067 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454169002068 NAD binding site [chemical binding]; other site 454169002069 catalytic Zn binding site [ion binding]; other site 454169002070 structural Zn binding site [ion binding]; other site 454169002071 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 454169002072 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 454169002073 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 454169002074 B1 nucleotide binding pocket [chemical binding]; other site 454169002075 B2 nucleotide binding pocket [chemical binding]; other site 454169002076 CAS motifs; other site 454169002077 active site 454169002078 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 454169002079 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 454169002080 transmembrane helices; other site 454169002081 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 454169002082 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 454169002083 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 454169002084 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 454169002085 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 454169002086 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 454169002087 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 454169002088 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 454169002089 putative active site [active] 454169002090 (T/H)XGH motif; other site 454169002091 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 454169002092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169002093 putative active site [active] 454169002094 heme pocket [chemical binding]; other site 454169002095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169002096 ATP binding site [chemical binding]; other site 454169002097 Mg2+ binding site [ion binding]; other site 454169002098 G-X-G motif; other site 454169002099 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 454169002100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169002101 active site 454169002102 phosphorylation site [posttranslational modification] 454169002103 intermolecular recognition site; other site 454169002104 dimerization interface [polypeptide binding]; other site 454169002105 Transcriptional regulator; Region: CitT; pfam12431 454169002106 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 454169002107 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 454169002108 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 454169002109 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454169002110 DNA-binding site [nucleotide binding]; DNA binding site 454169002111 RNA-binding motif; other site 454169002112 chromosome condensation membrane protein; Provisional; Region: PRK14196 454169002113 Predicted amidohydrolase [General function prediction only]; Region: COG0388 454169002114 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 454169002115 putative active site [active] 454169002116 catalytic triad [active] 454169002117 putative dimer interface [polypeptide binding]; other site 454169002118 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 454169002119 lipoyl synthase; Provisional; Region: PRK05481 454169002120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169002121 FeS/SAM binding site; other site 454169002122 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 454169002123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169002124 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 454169002125 substrate binding pocket [chemical binding]; other site 454169002126 dimerization interface [polypeptide binding]; other site 454169002127 lipoate-protein ligase B; Provisional; Region: PRK14342 454169002128 hypothetical protein; Provisional; Region: PRK04998 454169002129 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 454169002130 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 454169002131 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 454169002132 rare lipoprotein A; Provisional; Region: PRK10672 454169002133 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 454169002134 Sporulation related domain; Region: SPOR; pfam05036 454169002135 cell wall shape-determining protein; Provisional; Region: PRK10794 454169002136 penicillin-binding protein 2; Provisional; Region: PRK10795 454169002137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454169002138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454169002139 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 454169002140 ribosome-associated protein; Provisional; Region: PRK11538 454169002141 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454169002142 catalytic core [active] 454169002143 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 454169002144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169002145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169002146 homodimer interface [polypeptide binding]; other site 454169002147 catalytic residue [active] 454169002148 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 454169002149 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 454169002150 active site 454169002151 (T/H)XGH motif; other site 454169002152 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 454169002153 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 454169002154 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 454169002155 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 454169002156 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 454169002157 HIGH motif; other site 454169002158 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 454169002159 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 454169002160 active site 454169002161 KMSKS motif; other site 454169002162 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 454169002163 tRNA binding surface [nucleotide binding]; other site 454169002164 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 454169002165 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 454169002166 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 454169002167 Propionate catabolism activator; Region: PrpR_N; pfam06506 454169002168 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 454169002169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169002170 Walker A motif; other site 454169002171 ATP binding site [chemical binding]; other site 454169002172 Walker B motif; other site 454169002173 arginine finger; other site 454169002174 hypothetical protein; Provisional; Region: PRK11032 454169002175 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 454169002176 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169002177 Sel1-like repeats; Region: SEL1; smart00671 454169002178 Sel1-like repeats; Region: SEL1; smart00671 454169002179 Sel1-like repeats; Region: SEL1; smart00671 454169002180 Sel1-like repeats; Region: SEL1; smart00671 454169002181 Sel1-like repeats; Region: SEL1; smart00671 454169002182 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 454169002183 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 454169002184 HSP70 interaction site [polypeptide binding]; other site 454169002185 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 454169002186 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 454169002187 HSP70 interaction site [polypeptide binding]; other site 454169002188 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 454169002189 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 454169002190 nucleotide binding site [chemical binding]; other site 454169002191 putative NEF/HSP70 interaction site [polypeptide binding]; other site 454169002192 SBD interface [polypeptide binding]; other site 454169002193 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 454169002194 active site 454169002195 tetramer interface [polypeptide binding]; other site 454169002196 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 454169002197 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454169002198 Walker A/P-loop; other site 454169002199 ATP binding site [chemical binding]; other site 454169002200 Q-loop/lid; other site 454169002201 ABC transporter signature motif; other site 454169002202 Walker B; other site 454169002203 D-loop; other site 454169002204 H-loop/switch region; other site 454169002205 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169002206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002207 dimer interface [polypeptide binding]; other site 454169002208 conserved gate region; other site 454169002209 putative PBP binding loops; other site 454169002210 ABC-ATPase subunit interface; other site 454169002211 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169002212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002213 dimer interface [polypeptide binding]; other site 454169002214 conserved gate region; other site 454169002215 putative PBP binding loops; other site 454169002216 ABC-ATPase subunit interface; other site 454169002217 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 454169002218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169002219 substrate binding pocket [chemical binding]; other site 454169002220 membrane-bound complex binding site; other site 454169002221 hinge residues; other site 454169002222 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 454169002223 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 454169002224 putative active site [active] 454169002225 catalytic triad [active] 454169002226 putative dimer interface [polypeptide binding]; other site 454169002227 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 454169002228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454169002229 Transporter associated domain; Region: CorC_HlyC; smart01091 454169002230 metal-binding heat shock protein; Provisional; Region: PRK00016 454169002231 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 454169002232 PhoH-like protein; Region: PhoH; pfam02562 454169002233 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 454169002234 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 454169002235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169002236 FeS/SAM binding site; other site 454169002237 TRAM domain; Region: TRAM; pfam01938 454169002238 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 454169002239 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454169002240 asparagine synthetase B; Provisional; Region: asnB; PRK09431 454169002241 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 454169002242 active site 454169002243 dimer interface [polypeptide binding]; other site 454169002244 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 454169002245 Ligand Binding Site [chemical binding]; other site 454169002246 Molecular Tunnel; other site 454169002247 UMP phosphatase; Provisional; Region: PRK10444 454169002248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002249 active site 454169002250 motif I; other site 454169002251 motif II; other site 454169002252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002253 MarR family; Region: MarR; pfam01047 454169002254 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 454169002255 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169002256 nucleotide binding site [chemical binding]; other site 454169002257 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 454169002258 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 454169002259 active site 454169002260 dimer interface [polypeptide binding]; other site 454169002261 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 454169002262 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 454169002263 active site 454169002264 trimer interface [polypeptide binding]; other site 454169002265 allosteric site; other site 454169002266 active site lid [active] 454169002267 hexamer (dimer of trimers) interface [polypeptide binding]; other site 454169002268 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 454169002269 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454169002270 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454169002271 active site turn [active] 454169002272 phosphorylation site [posttranslational modification] 454169002273 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 454169002274 HPr interaction site; other site 454169002275 glycerol kinase (GK) interaction site [polypeptide binding]; other site 454169002276 active site 454169002277 phosphorylation site [posttranslational modification] 454169002278 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 454169002279 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 454169002280 active site 454169002281 HIGH motif; other site 454169002282 nucleotide binding site [chemical binding]; other site 454169002283 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 454169002284 KMSKS motif; other site 454169002285 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 454169002286 outer membrane porin, OprD family; Region: OprD; pfam03573 454169002287 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 454169002288 YbfN-like lipoprotein; Region: YbfN; pfam13982 454169002289 citrate-proton symporter; Provisional; Region: PRK15075 454169002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169002291 putative substrate translocation pore; other site 454169002292 tricarballylate utilization protein B; Provisional; Region: PRK15033 454169002293 tricarballylate dehydrogenase; Validated; Region: PRK08274 454169002294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169002295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169002296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169002297 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 454169002298 putative dimerization interface [polypeptide binding]; other site 454169002299 ferric uptake regulator; Provisional; Region: fur; PRK09462 454169002300 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 454169002301 metal binding site 2 [ion binding]; metal-binding site 454169002302 putative DNA binding helix; other site 454169002303 metal binding site 1 [ion binding]; metal-binding site 454169002304 dimer interface [polypeptide binding]; other site 454169002305 structural Zn2+ binding site [ion binding]; other site 454169002306 flavodoxin FldA; Validated; Region: PRK09267 454169002307 LexA regulated protein; Provisional; Region: PRK11675 454169002308 acyl-CoA esterase; Provisional; Region: PRK10673 454169002309 PGAP1-like protein; Region: PGAP1; pfam07819 454169002310 replication initiation regulator SeqA; Provisional; Region: PRK11187 454169002311 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 454169002312 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 454169002313 active site 454169002314 substrate binding site [chemical binding]; other site 454169002315 metal binding site [ion binding]; metal-binding site 454169002316 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 454169002317 putrescine transporter; Provisional; Region: potE; PRK10655 454169002318 ornithine decarboxylase; Provisional; Region: PRK13578 454169002319 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454169002320 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454169002321 homodimer interface [polypeptide binding]; other site 454169002322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169002323 catalytic residue [active] 454169002324 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454169002325 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 454169002326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169002327 active site 454169002328 phosphorylation site [posttranslational modification] 454169002329 intermolecular recognition site; other site 454169002330 dimerization interface [polypeptide binding]; other site 454169002331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169002332 DNA binding site [nucleotide binding] 454169002333 sensor protein KdpD; Provisional; Region: PRK10490 454169002334 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 454169002335 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 454169002336 Ligand Binding Site [chemical binding]; other site 454169002337 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 454169002338 GAF domain; Region: GAF_3; pfam13492 454169002339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169002340 dimer interface [polypeptide binding]; other site 454169002341 phosphorylation site [posttranslational modification] 454169002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169002343 ATP binding site [chemical binding]; other site 454169002344 Mg2+ binding site [ion binding]; other site 454169002345 G-X-G motif; other site 454169002346 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 454169002347 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 454169002348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454169002349 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 454169002350 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 454169002351 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 454169002352 DNA photolyase; Region: DNA_photolyase; pfam00875 454169002353 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 454169002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169002355 putative substrate translocation pore; other site 454169002356 POT family; Region: PTR2; pfam00854 454169002357 Uncharacterized conserved protein [Function unknown]; Region: COG0327 454169002358 metal-binding protein; Provisional; Region: PRK10799 454169002359 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 454169002360 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 454169002361 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 454169002362 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 454169002363 putative active site [active] 454169002364 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454169002365 active site 454169002366 DNA binding site [nucleotide binding] 454169002367 Int/Topo IB signature motif; other site 454169002368 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 454169002369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454169002370 UDP-galactopyranose mutase; Region: GLF; pfam03275 454169002371 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 454169002372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169002373 active site 454169002374 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454169002375 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 454169002376 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 454169002377 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 454169002378 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 454169002379 Walker A/P-loop; other site 454169002380 ATP binding site [chemical binding]; other site 454169002381 Q-loop/lid; other site 454169002382 ABC transporter signature motif; other site 454169002383 Walker B; other site 454169002384 D-loop; other site 454169002385 H-loop/switch region; other site 454169002386 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 454169002387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169002388 active site 454169002389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169002390 active site 454169002391 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 454169002392 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 454169002393 endonuclease VIII; Provisional; Region: PRK10445 454169002394 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 454169002395 DNA binding site [nucleotide binding] 454169002396 catalytic residue [active] 454169002397 putative catalytic residues [active] 454169002398 H2TH interface [polypeptide binding]; other site 454169002399 intercalation triad [nucleotide binding]; other site 454169002400 substrate specificity determining residue; other site 454169002401 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 454169002402 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 454169002403 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 454169002404 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 454169002405 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 454169002406 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 454169002407 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 454169002408 dimer interface [polypeptide binding]; other site 454169002409 active site 454169002410 citrylCoA binding site [chemical binding]; other site 454169002411 NADH binding [chemical binding]; other site 454169002412 cationic pore residues; other site 454169002413 oxalacetate/citrate binding site [chemical binding]; other site 454169002414 coenzyme A binding site [chemical binding]; other site 454169002415 catalytic triad [active] 454169002416 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 454169002417 Iron-sulfur protein interface; other site 454169002418 proximal quinone binding site [chemical binding]; other site 454169002419 SdhD (CybS) interface [polypeptide binding]; other site 454169002420 proximal heme binding site [chemical binding]; other site 454169002421 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 454169002422 SdhC subunit interface [polypeptide binding]; other site 454169002423 proximal heme binding site [chemical binding]; other site 454169002424 cardiolipin binding site; other site 454169002425 Iron-sulfur protein interface; other site 454169002426 proximal quinone binding site [chemical binding]; other site 454169002427 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 454169002428 L-aspartate oxidase; Provisional; Region: PRK06175 454169002429 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 454169002430 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 454169002431 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 454169002432 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 454169002433 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 454169002434 TPP-binding site [chemical binding]; other site 454169002435 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 454169002436 dimer interface [polypeptide binding]; other site 454169002437 PYR/PP interface [polypeptide binding]; other site 454169002438 TPP binding site [chemical binding]; other site 454169002439 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 454169002440 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454169002441 E3 interaction surface; other site 454169002442 lipoyl attachment site [posttranslational modification]; other site 454169002443 e3 binding domain; Region: E3_binding; pfam02817 454169002444 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 454169002445 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 454169002446 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 454169002447 CoA-ligase; Region: Ligase_CoA; pfam00549 454169002448 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 454169002449 CoA binding domain; Region: CoA_binding; smart00881 454169002450 CoA-ligase; Region: Ligase_CoA; pfam00549 454169002451 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 454169002452 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 454169002453 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 454169002454 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 454169002455 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 454169002456 hypothetical protein; Provisional; Region: PRK10588 454169002457 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 454169002458 active site 454169002459 colicin uptake protein TolQ; Provisional; Region: PRK10801 454169002460 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 454169002461 colicin uptake protein TolR; Provisional; Region: PRK11024 454169002462 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 454169002463 TolA C-terminal; Region: TolA; pfam06519 454169002464 translocation protein TolB; Provisional; Region: tolB; PRK03629 454169002465 TolB amino-terminal domain; Region: TolB_N; pfam04052 454169002466 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 454169002467 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 454169002468 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 454169002469 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 454169002470 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454169002471 ligand binding site [chemical binding]; other site 454169002472 tol-pal system protein YbgF; Provisional; Region: PRK10803 454169002473 Tetratricopeptide repeat; Region: TPR_6; pfam13174 454169002474 Tetratricopeptide repeat; Region: TPR_6; pfam13174 454169002475 quinolinate synthetase; Provisional; Region: PRK09375 454169002476 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 454169002477 zinc transporter ZitB; Provisional; Region: PRK03557 454169002478 YbgS-like protein; Region: YbgS; pfam13985 454169002479 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 454169002480 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454169002481 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 454169002482 fumarate hydratase; Provisional; Region: PRK06246 454169002483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169002484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169002485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169002486 dimerization interface [polypeptide binding]; other site 454169002487 cell density-dependent motility repressor; Provisional; Region: PRK10082 454169002488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169002489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169002490 dimerization interface [polypeptide binding]; other site 454169002491 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 454169002492 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454169002493 transmembrane helices; other site 454169002494 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 454169002495 oxaloacetate decarboxylase; Provisional; Region: PRK14040 454169002496 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 454169002497 active site 454169002498 catalytic residues [active] 454169002499 metal binding site [ion binding]; metal-binding site 454169002500 homodimer binding site [polypeptide binding]; other site 454169002501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454169002502 carboxyltransferase (CT) interaction site; other site 454169002503 biotinylation site [posttranslational modification]; other site 454169002504 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 454169002505 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 454169002506 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454169002507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169002508 dimer interface [polypeptide binding]; other site 454169002509 putative PBP binding regions; other site 454169002510 ABC-ATPase subunit interface; other site 454169002511 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 454169002512 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454169002513 Walker A/P-loop; other site 454169002514 ATP binding site [chemical binding]; other site 454169002515 Q-loop/lid; other site 454169002516 ABC transporter signature motif; other site 454169002517 Walker B; other site 454169002518 D-loop; other site 454169002519 H-loop/switch region; other site 454169002520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454169002521 catalytic core [active] 454169002522 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454169002523 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 454169002524 active site 454169002525 catalytic residues [active] 454169002526 galactokinase; Provisional; Region: PRK05101 454169002527 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 454169002528 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 454169002529 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 454169002530 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 454169002531 dimer interface [polypeptide binding]; other site 454169002532 active site 454169002533 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 454169002534 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 454169002535 NAD binding site [chemical binding]; other site 454169002536 homodimer interface [polypeptide binding]; other site 454169002537 active site 454169002538 substrate binding site [chemical binding]; other site 454169002539 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 454169002540 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 454169002541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169002542 Walker A/P-loop; other site 454169002543 ATP binding site [chemical binding]; other site 454169002544 Q-loop/lid; other site 454169002545 ABC transporter signature motif; other site 454169002546 Walker B; other site 454169002547 D-loop; other site 454169002548 H-loop/switch region; other site 454169002549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169002550 Walker A/P-loop; other site 454169002551 ATP binding site [chemical binding]; other site 454169002552 Q-loop/lid; other site 454169002553 ABC transporter signature motif; other site 454169002554 Walker B; other site 454169002555 D-loop; other site 454169002556 H-loop/switch region; other site 454169002557 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 454169002558 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 454169002559 molybdenum-pterin binding domain; Region: Mop; TIGR00638 454169002560 TOBE domain; Region: TOBE; pfam03459 454169002561 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 454169002562 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 454169002563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169002564 substrate binding pocket [chemical binding]; other site 454169002565 membrane-bound complex binding site; other site 454169002566 hinge residues; other site 454169002567 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 454169002568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002569 dimer interface [polypeptide binding]; other site 454169002570 conserved gate region; other site 454169002571 putative PBP binding loops; other site 454169002572 ABC-ATPase subunit interface; other site 454169002573 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 454169002574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169002575 Walker A/P-loop; other site 454169002576 ATP binding site [chemical binding]; other site 454169002577 Q-loop/lid; other site 454169002578 ABC transporter signature motif; other site 454169002579 Walker B; other site 454169002580 D-loop; other site 454169002581 H-loop/switch region; other site 454169002582 molybdenum-pterin binding domain; Region: Mop; TIGR00638 454169002583 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 454169002584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002585 active site 454169002586 motif I; other site 454169002587 motif II; other site 454169002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002589 6-phosphogluconolactonase; Provisional; Region: PRK11028 454169002590 acyl-CoA thioesterase; Provisional; Region: PRK10531 454169002591 putative pectinesterase; Region: PLN02432; cl01911 454169002592 imidazolonepropionase; Validated; Region: PRK09356 454169002593 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 454169002594 active site 454169002595 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 454169002596 putative active site [active] 454169002597 putative metal binding site [ion binding]; other site 454169002598 histidine utilization repressor; Provisional; Region: PRK14999 454169002599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169002600 DNA-binding site [nucleotide binding]; DNA binding site 454169002601 UTRA domain; Region: UTRA; pfam07702 454169002602 urocanate hydratase; Provisional; Region: PRK05414 454169002603 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 454169002604 active sites [active] 454169002605 tetramer interface [polypeptide binding]; other site 454169002606 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 454169002607 substrate binding site [chemical binding]; other site 454169002608 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 454169002609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454169002610 inhibitor-cofactor binding pocket; inhibition site 454169002611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169002612 catalytic residue [active] 454169002613 biotin synthase; Provisional; Region: PRK15108 454169002614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169002615 FeS/SAM binding site; other site 454169002616 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 454169002617 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 454169002618 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 454169002619 substrate-cofactor binding pocket; other site 454169002620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169002621 catalytic residue [active] 454169002622 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 454169002623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169002624 S-adenosylmethionine binding site [chemical binding]; other site 454169002625 AAA domain; Region: AAA_26; pfam13500 454169002626 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 454169002627 excinuclease ABC subunit B; Provisional; Region: PRK05298 454169002628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169002629 ATP binding site [chemical binding]; other site 454169002630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169002631 nucleotide binding region [chemical binding]; other site 454169002632 ATP-binding site [chemical binding]; other site 454169002633 Ultra-violet resistance protein B; Region: UvrB; pfam12344 454169002634 UvrB/uvrC motif; Region: UVR; pfam02151 454169002635 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 454169002636 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 454169002637 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 454169002638 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 454169002639 Leucine-rich repeats; other site 454169002640 Substrate binding site [chemical binding]; other site 454169002641 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 454169002642 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 454169002643 putative substrate binding pocket [chemical binding]; other site 454169002644 dimer interface [polypeptide binding]; other site 454169002645 phosphate binding site [ion binding]; other site 454169002646 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 454169002647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169002648 FeS/SAM binding site; other site 454169002649 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 454169002650 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 454169002651 MPT binding site; other site 454169002652 trimer interface [polypeptide binding]; other site 454169002653 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 454169002654 trimer interface [polypeptide binding]; other site 454169002655 dimer interface [polypeptide binding]; other site 454169002656 putative active site [active] 454169002657 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 454169002658 MoaE interaction surface [polypeptide binding]; other site 454169002659 MoeB interaction surface [polypeptide binding]; other site 454169002660 thiocarboxylated glycine; other site 454169002661 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 454169002662 MoaE homodimer interface [polypeptide binding]; other site 454169002663 MoaD interaction [polypeptide binding]; other site 454169002664 active site residues [active] 454169002665 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454169002666 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 454169002667 Transposase domain (DUF772); Region: DUF772; pfam05598 454169002668 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169002669 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169002670 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454169002671 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 454169002672 Predicted integral membrane protein [Function unknown]; Region: COG0392 454169002673 cardiolipin synthase 2; Provisional; Region: PRK11263 454169002674 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 454169002675 putative active site [active] 454169002676 catalytic site [active] 454169002677 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 454169002678 putative active site [active] 454169002679 catalytic site [active] 454169002680 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 454169002681 putative catalytic site [active] 454169002682 putative metal binding site [ion binding]; other site 454169002683 putative phosphate binding site [ion binding]; other site 454169002684 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 454169002685 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454169002686 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 454169002687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454169002688 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 454169002689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 454169002690 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454169002691 Walker A/P-loop; other site 454169002692 ATP binding site [chemical binding]; other site 454169002693 Q-loop/lid; other site 454169002694 ABC transporter signature motif; other site 454169002695 Walker B; other site 454169002696 D-loop; other site 454169002697 H-loop/switch region; other site 454169002698 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 454169002699 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454169002700 Walker A/P-loop; other site 454169002701 ATP binding site [chemical binding]; other site 454169002702 Q-loop/lid; other site 454169002703 ABC transporter signature motif; other site 454169002704 Walker B; other site 454169002705 D-loop; other site 454169002706 H-loop/switch region; other site 454169002707 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 454169002708 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169002709 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169002710 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 454169002711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169002712 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 454169002713 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 454169002714 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454169002715 ATP binding site [chemical binding]; other site 454169002716 Mg++ binding site [ion binding]; other site 454169002717 motif III; other site 454169002718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169002719 nucleotide binding region [chemical binding]; other site 454169002720 ATP-binding site [chemical binding]; other site 454169002721 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 454169002722 DEAD_2; Region: DEAD_2; pfam06733 454169002723 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 454169002724 glycosyl transferase family protein; Provisional; Region: PRK08136 454169002725 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 454169002726 hypothetical protein; Provisional; Region: PRK10259 454169002727 hypothetical protein; Provisional; Region: PRK11019 454169002728 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 454169002729 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 454169002730 putative mechanosensitive channel protein; Provisional; Region: PRK11465 454169002731 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169002732 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 454169002733 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454169002734 Walker A/P-loop; other site 454169002735 ATP binding site [chemical binding]; other site 454169002736 Q-loop/lid; other site 454169002737 ABC transporter signature motif; other site 454169002738 Walker B; other site 454169002739 D-loop; other site 454169002740 H-loop/switch region; other site 454169002741 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169002742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002743 dimer interface [polypeptide binding]; other site 454169002744 conserved gate region; other site 454169002745 putative PBP binding loops; other site 454169002746 ABC-ATPase subunit interface; other site 454169002747 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 454169002748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169002749 substrate binding pocket [chemical binding]; other site 454169002750 membrane-bound complex binding site; other site 454169002751 hinge residues; other site 454169002752 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 454169002753 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 454169002754 dimerization interface [polypeptide binding]; other site 454169002755 DPS ferroxidase diiron center [ion binding]; other site 454169002756 ion pore; other site 454169002757 threonine and homoserine efflux system; Provisional; Region: PRK10532 454169002758 EamA-like transporter family; Region: EamA; pfam00892 454169002759 outer membrane protein X; Provisional; Region: ompX; PRK09408 454169002760 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 454169002761 Sulfatase; Region: Sulfatase; pfam00884 454169002762 manganese transport regulator MntR; Provisional; Region: PRK11050 454169002763 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 454169002764 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 454169002765 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 454169002766 transmembrane helices; other site 454169002767 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 454169002768 L,D-transpeptidase; Provisional; Region: PRK10260 454169002769 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169002770 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 454169002771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169002772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169002773 Walker A/P-loop; other site 454169002774 ATP binding site [chemical binding]; other site 454169002775 ABC transporter signature motif; other site 454169002776 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169002777 Walker B; other site 454169002778 ABC transporter; Region: ABC_tran_2; pfam12848 454169002779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169002780 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 454169002781 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 454169002782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002783 active site 454169002784 motif I; other site 454169002785 motif II; other site 454169002786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002787 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 454169002788 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 454169002789 dimer interface [polypeptide binding]; other site 454169002790 active site 454169002791 glycine loop; other site 454169002792 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 454169002793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169002794 FeS/SAM binding site; other site 454169002795 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 454169002796 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 454169002797 ATP binding site [chemical binding]; other site 454169002798 substrate interface [chemical binding]; other site 454169002799 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 454169002800 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 454169002801 dimer interface [polypeptide binding]; other site 454169002802 putative functional site; other site 454169002803 putative MPT binding site; other site 454169002804 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 454169002805 catalytic nucleophile [active] 454169002806 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 454169002807 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169002808 Walker A/P-loop; other site 454169002809 ATP binding site [chemical binding]; other site 454169002810 Q-loop/lid; other site 454169002811 ABC transporter signature motif; other site 454169002812 Walker B; other site 454169002813 D-loop; other site 454169002814 H-loop/switch region; other site 454169002815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454169002816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169002817 Walker A/P-loop; other site 454169002818 ATP binding site [chemical binding]; other site 454169002819 Q-loop/lid; other site 454169002820 ABC transporter signature motif; other site 454169002821 Walker B; other site 454169002822 D-loop; other site 454169002823 H-loop/switch region; other site 454169002824 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 454169002825 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 454169002826 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 454169002827 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 454169002828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002829 dimer interface [polypeptide binding]; other site 454169002830 conserved gate region; other site 454169002831 putative PBP binding loops; other site 454169002832 ABC-ATPase subunit interface; other site 454169002833 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 454169002834 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454169002835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002836 dimer interface [polypeptide binding]; other site 454169002837 conserved gate region; other site 454169002838 putative PBP binding loops; other site 454169002839 ABC-ATPase subunit interface; other site 454169002840 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 454169002841 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 454169002842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169002843 FeS/SAM binding site; other site 454169002844 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 454169002845 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 454169002846 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 454169002847 Ligand binding site [chemical binding]; other site 454169002848 Electron transfer flavoprotein domain; Region: ETF; pfam01012 454169002849 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 454169002850 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 454169002851 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 454169002852 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 454169002853 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 454169002854 active site 454169002855 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 454169002856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169002857 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 454169002858 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 454169002859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169002860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169002861 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 454169002862 putative dimerization interface [polypeptide binding]; other site 454169002863 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 454169002864 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 454169002865 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 454169002866 putative C-terminal domain interface [polypeptide binding]; other site 454169002867 putative GSH binding site (G-site) [chemical binding]; other site 454169002868 putative dimer interface [polypeptide binding]; other site 454169002869 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 454169002870 putative N-terminal domain interface [polypeptide binding]; other site 454169002871 putative dimer interface [polypeptide binding]; other site 454169002872 putative substrate binding pocket (H-site) [chemical binding]; other site 454169002873 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 454169002874 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 454169002875 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 454169002876 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 454169002877 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454169002878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169002879 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454169002880 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 454169002881 active site 454169002882 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 454169002883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169002884 putative substrate translocation pore; other site 454169002885 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 454169002886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002887 active site 454169002888 motif I; other site 454169002889 motif II; other site 454169002890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169002891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169002892 putative substrate translocation pore; other site 454169002893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169002894 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 454169002895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169002896 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 454169002897 putative transporter; Provisional; Region: PRK04972 454169002898 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 454169002899 TrkA-C domain; Region: TrkA_C; pfam02080 454169002900 TrkA-C domain; Region: TrkA_C; pfam02080 454169002901 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 454169002902 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 454169002903 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 454169002904 GSH binding site [chemical binding]; other site 454169002905 catalytic residues [active] 454169002906 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 454169002907 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 454169002908 dimer interface [polypeptide binding]; other site 454169002909 FMN binding site [chemical binding]; other site 454169002910 NADPH bind site [chemical binding]; other site 454169002911 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 454169002912 RimK-like ATP-grasp domain; Region: RimK; pfam08443 454169002913 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 454169002914 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 454169002915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 454169002916 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 454169002917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169002918 Walker A/P-loop; other site 454169002919 ATP binding site [chemical binding]; other site 454169002920 Q-loop/lid; other site 454169002921 ABC transporter signature motif; other site 454169002922 Walker B; other site 454169002923 D-loop; other site 454169002924 H-loop/switch region; other site 454169002925 TOBE domain; Region: TOBE_2; pfam08402 454169002926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002927 dimer interface [polypeptide binding]; other site 454169002928 conserved gate region; other site 454169002929 putative PBP binding loops; other site 454169002930 ABC-ATPase subunit interface; other site 454169002931 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 454169002932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002933 dimer interface [polypeptide binding]; other site 454169002934 conserved gate region; other site 454169002935 putative PBP binding loops; other site 454169002936 ABC-ATPase subunit interface; other site 454169002937 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 454169002938 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 454169002939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169002940 S-adenosylmethionine binding site [chemical binding]; other site 454169002941 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 454169002942 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 454169002943 active site 454169002944 P-loop; other site 454169002945 phosphorylation site [posttranslational modification] 454169002946 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454169002947 Sulfatase; Region: Sulfatase; cl17466 454169002948 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 454169002949 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169002950 substrate binding pocket [chemical binding]; other site 454169002951 membrane-bound complex binding site; other site 454169002952 hinge residues; other site 454169002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002954 dimer interface [polypeptide binding]; other site 454169002955 conserved gate region; other site 454169002956 putative PBP binding loops; other site 454169002957 ABC-ATPase subunit interface; other site 454169002958 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169002959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169002960 dimer interface [polypeptide binding]; other site 454169002961 conserved gate region; other site 454169002962 putative PBP binding loops; other site 454169002963 ABC-ATPase subunit interface; other site 454169002964 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 454169002965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169002966 substrate binding pocket [chemical binding]; other site 454169002967 membrane-bound complex binding site; other site 454169002968 hinge residues; other site 454169002969 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 454169002970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169002971 Walker A/P-loop; other site 454169002972 ATP binding site [chemical binding]; other site 454169002973 Q-loop/lid; other site 454169002974 ABC transporter signature motif; other site 454169002975 Walker B; other site 454169002976 D-loop; other site 454169002977 H-loop/switch region; other site 454169002978 putative lipoprotein; Provisional; Region: PRK10533 454169002979 hypothetical protein; Provisional; Region: PRK02877 454169002980 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 454169002981 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 454169002982 amidase catalytic site [active] 454169002983 Zn binding residues [ion binding]; other site 454169002984 substrate binding site [chemical binding]; other site 454169002985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 454169002986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454169002987 NAD(P) binding site [chemical binding]; other site 454169002988 active site 454169002989 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 454169002990 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 454169002991 putative NAD(P) binding site [chemical binding]; other site 454169002992 putative active site [active] 454169002993 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 454169002994 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 454169002995 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 454169002996 tetramer interface [polypeptide binding]; other site 454169002997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169002998 catalytic residue [active] 454169002999 pyruvate dehydrogenase; Provisional; Region: PRK09124 454169003000 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 454169003001 PYR/PP interface [polypeptide binding]; other site 454169003002 dimer interface [polypeptide binding]; other site 454169003003 tetramer interface [polypeptide binding]; other site 454169003004 TPP binding site [chemical binding]; other site 454169003005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454169003006 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 454169003007 TPP-binding site [chemical binding]; other site 454169003008 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 454169003009 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 454169003010 FAD binding pocket [chemical binding]; other site 454169003011 FAD binding motif [chemical binding]; other site 454169003012 phosphate binding motif [ion binding]; other site 454169003013 beta-alpha-beta structure motif; other site 454169003014 NAD binding pocket [chemical binding]; other site 454169003015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454169003016 catalytic loop [active] 454169003017 iron binding site [ion binding]; other site 454169003018 hybrid cluster protein; Provisional; Region: PRK05290 454169003019 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169003020 ACS interaction site; other site 454169003021 CODH interaction site; other site 454169003022 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 454169003023 hybrid metal cluster; other site 454169003024 Predicted membrane protein [Function unknown]; Region: COG2431 454169003025 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 454169003026 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 454169003027 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 454169003028 putative active site [active] 454169003029 putative metal-binding site [ion binding]; other site 454169003030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 454169003031 macrolide transporter subunit MacA; Provisional; Region: PRK11578 454169003032 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169003033 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169003034 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 454169003035 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 454169003036 Walker A/P-loop; other site 454169003037 ATP binding site [chemical binding]; other site 454169003038 Q-loop/lid; other site 454169003039 ABC transporter signature motif; other site 454169003040 Walker B; other site 454169003041 D-loop; other site 454169003042 H-loop/switch region; other site 454169003043 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 454169003044 FtsX-like permease family; Region: FtsX; pfam02687 454169003045 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454169003046 DNA-binding site [nucleotide binding]; DNA binding site 454169003047 RNA-binding motif; other site 454169003048 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 454169003049 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 454169003050 Clp amino terminal domain; Region: Clp_N; pfam02861 454169003051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169003052 Walker A motif; other site 454169003053 ATP binding site [chemical binding]; other site 454169003054 Walker B motif; other site 454169003055 arginine finger; other site 454169003056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169003057 Walker A motif; other site 454169003058 ATP binding site [chemical binding]; other site 454169003059 Walker B motif; other site 454169003060 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 454169003061 Transposase IS200 like; Region: Y1_Tnp; pfam01797 454169003062 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454169003063 DNA binding site [nucleotide binding] 454169003064 active site 454169003065 Int/Topo IB signature motif; other site 454169003066 Isochorismatase family; Region: Isochorismatase; pfam00857 454169003067 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 454169003068 catalytic triad [active] 454169003069 dimer interface [polypeptide binding]; other site 454169003070 conserved cis-peptide bond; other site 454169003071 Pirin-related protein [General function prediction only]; Region: COG1741 454169003072 Pirin; Region: Pirin; pfam02678 454169003073 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 454169003074 LysR family transcriptional regulator; Provisional; Region: PRK14997 454169003075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169003076 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 454169003077 putative effector binding pocket; other site 454169003078 putative dimerization interface [polypeptide binding]; other site 454169003079 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 454169003080 rRNA binding site [nucleotide binding]; other site 454169003081 predicted 30S ribosome binding site; other site 454169003082 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 454169003083 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 454169003084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169003085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169003086 Walker A/P-loop; other site 454169003087 ATP binding site [chemical binding]; other site 454169003088 Q-loop/lid; other site 454169003089 ABC transporter signature motif; other site 454169003090 Walker B; other site 454169003091 D-loop; other site 454169003092 H-loop/switch region; other site 454169003093 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 454169003094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169003095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169003096 Walker A/P-loop; other site 454169003097 ATP binding site [chemical binding]; other site 454169003098 Q-loop/lid; other site 454169003099 ABC transporter signature motif; other site 454169003100 Walker B; other site 454169003101 D-loop; other site 454169003102 H-loop/switch region; other site 454169003103 thioredoxin reductase; Provisional; Region: PRK10262 454169003104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169003105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169003106 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 454169003107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169003108 putative DNA binding site [nucleotide binding]; other site 454169003109 putative Zn2+ binding site [ion binding]; other site 454169003110 AsnC family; Region: AsnC_trans_reg; pfam01037 454169003111 DNA translocase FtsK; Provisional; Region: PRK10263 454169003112 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 454169003113 DNA translocase FtsK; Provisional; Region: PRK10263 454169003114 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 454169003115 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 454169003116 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 454169003117 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 454169003118 recombination factor protein RarA; Reviewed; Region: PRK13342 454169003119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169003120 Walker A motif; other site 454169003121 ATP binding site [chemical binding]; other site 454169003122 Walker B motif; other site 454169003123 arginine finger; other site 454169003124 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 454169003125 seryl-tRNA synthetase; Provisional; Region: PRK05431 454169003126 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 454169003127 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 454169003128 dimer interface [polypeptide binding]; other site 454169003129 active site 454169003130 motif 1; other site 454169003131 motif 2; other site 454169003132 motif 3; other site 454169003133 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 454169003134 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454169003135 putative [Fe4-S4] binding site [ion binding]; other site 454169003136 putative molybdopterin cofactor binding site [chemical binding]; other site 454169003137 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454169003138 putative molybdopterin cofactor binding site; other site 454169003139 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454169003140 4Fe-4S binding domain; Region: Fer4; pfam00037 454169003141 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 454169003142 putative MFS family transporter protein; Provisional; Region: PRK03633 454169003143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169003144 putative substrate translocation pore; other site 454169003145 inner membrane transporter YjeM; Provisional; Region: PRK15238 454169003146 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 454169003147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169003148 FeS/SAM binding site; other site 454169003149 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 454169003150 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 454169003151 Pyruvate formate lyase 1; Region: PFL1; cd01678 454169003152 coenzyme A binding site [chemical binding]; other site 454169003153 active site 454169003154 catalytic residues [active] 454169003155 glycine loop; other site 454169003156 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 454169003157 uncharacterized domain; Region: TIGR00702 454169003158 YcaO-like family; Region: YcaO; pfam02624 454169003159 Predicted membrane protein [Function unknown]; Region: COG2323 454169003160 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 454169003161 homodimer interface [polypeptide binding]; other site 454169003162 substrate-cofactor binding pocket; other site 454169003163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169003164 catalytic residue [active] 454169003165 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 454169003166 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 454169003167 hinge; other site 454169003168 active site 454169003169 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 454169003170 cytidylate kinase; Provisional; Region: cmk; PRK00023 454169003171 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 454169003172 CMP-binding site; other site 454169003173 The sites determining sugar specificity; other site 454169003174 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 454169003175 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 454169003176 RNA binding site [nucleotide binding]; other site 454169003177 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 454169003178 RNA binding site [nucleotide binding]; other site 454169003179 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 454169003180 RNA binding site [nucleotide binding]; other site 454169003181 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 454169003182 RNA binding site [nucleotide binding]; other site 454169003183 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 454169003184 RNA binding site [nucleotide binding]; other site 454169003185 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454169003186 IHF dimer interface [polypeptide binding]; other site 454169003187 IHF - DNA interface [nucleotide binding]; other site 454169003188 ComEC family competence protein; Provisional; Region: PRK11539 454169003189 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 454169003190 Competence protein; Region: Competence; pfam03772 454169003191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 454169003192 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 454169003193 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169003194 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 454169003195 Walker A/P-loop; other site 454169003196 ATP binding site [chemical binding]; other site 454169003197 Q-loop/lid; other site 454169003198 ABC transporter signature motif; other site 454169003199 Walker B; other site 454169003200 D-loop; other site 454169003201 H-loop/switch region; other site 454169003202 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 454169003203 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 454169003204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 454169003205 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 454169003206 hypothetical protein; Provisional; Region: PRK11827 454169003207 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 454169003208 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 454169003209 Ligand binding site; other site 454169003210 oligomer interface; other site 454169003211 hypothetical protein; Provisional; Region: PRK10593 454169003212 Uncharacterized conserved protein [Function unknown]; Region: COG1434 454169003213 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454169003214 putative active site [active] 454169003215 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 454169003216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169003217 S-adenosylmethionine binding site [chemical binding]; other site 454169003218 condesin subunit F; Provisional; Region: PRK05260 454169003219 condesin subunit E; Provisional; Region: PRK05256 454169003220 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 454169003221 P-loop containing region of AAA domain; Region: AAA_29; cl17516 454169003222 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 454169003223 murein L,D-transpeptidase; Provisional; Region: PRK10594 454169003224 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 454169003225 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169003226 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 454169003228 Peptidase M15; Region: Peptidase_M15_3; cl01194 454169003229 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 454169003230 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 454169003231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169003232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169003233 homodimer interface [polypeptide binding]; other site 454169003234 catalytic residue [active] 454169003235 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169003236 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169003237 trimer interface [polypeptide binding]; other site 454169003238 eyelet of channel; other site 454169003239 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 454169003240 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 454169003241 putative dimer interface [polypeptide binding]; other site 454169003242 putative anticodon binding site; other site 454169003243 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 454169003244 homodimer interface [polypeptide binding]; other site 454169003245 motif 1; other site 454169003246 motif 2; other site 454169003247 active site 454169003248 motif 3; other site 454169003249 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 454169003250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169003251 putative DNA binding site [nucleotide binding]; other site 454169003252 putative Zn2+ binding site [ion binding]; other site 454169003253 AsnC family; Region: AsnC_trans_reg; pfam01037 454169003254 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 454169003255 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 454169003256 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169003257 catalytic residue [active] 454169003258 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 454169003259 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 454169003260 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 454169003261 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 454169003262 active site 454169003263 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 454169003264 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 454169003265 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 454169003266 Int/Topo IB signature motif; other site 454169003267 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 454169003268 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 454169003269 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 454169003270 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 454169003271 phage recombination protein Bet; Region: bet_lambda; TIGR01913 454169003272 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 454169003273 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 454169003274 Tetrahydromethanopterin S-methyltransferase, subunit G; Region: MtrG; cl01679 454169003275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169003276 transcriptional repressor DicA; Reviewed; Region: PRK09706 454169003277 non-specific DNA binding site [nucleotide binding]; other site 454169003278 salt bridge; other site 454169003279 sequence-specific DNA binding site [nucleotide binding]; other site 454169003280 Bacteriophage CII protein; Region: Phage_CII; pfam05269 454169003281 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 454169003282 Replication protein P; Region: Phage_lambda_P; pfam06992 454169003283 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 454169003284 Transposase domain (DUF772); Region: DUF772; pfam05598 454169003285 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169003286 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169003287 DinI-like family; Region: DinI; pfam06183 454169003288 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 454169003289 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 454169003290 Antitermination protein; Region: Antiterm; pfam03589 454169003291 Antitermination protein; Region: Antiterm; pfam03589 454169003292 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 454169003293 catalytic residues [active] 454169003294 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 454169003295 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 454169003296 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 454169003297 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 454169003298 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 454169003299 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 454169003300 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 454169003301 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 454169003302 oligomer interface [polypeptide binding]; other site 454169003303 active site residues [active] 454169003304 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 454169003305 Uncharacterized conserved protein [Function unknown]; Region: COG5471 454169003306 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 454169003307 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 454169003308 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 454169003309 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 454169003310 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 454169003311 Minor tail protein T; Region: Phage_tail_T; cl05636 454169003312 Phage-related minor tail protein [Function unknown]; Region: COG5281 454169003313 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 454169003314 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 454169003315 Phage-related protein [Function unknown]; Region: COG4718 454169003316 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 454169003317 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 454169003318 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 454169003319 E-class dimer interface [polypeptide binding]; other site 454169003320 P-class dimer interface [polypeptide binding]; other site 454169003321 active site 454169003322 Cu2+ binding site [ion binding]; other site 454169003323 Zn2+ binding site [ion binding]; other site 454169003324 Phage-related protein [Function unknown]; Region: gp18; COG4672 454169003325 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 454169003326 MPN+ (JAMM) motif; other site 454169003327 Zinc-binding site [ion binding]; other site 454169003328 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 454169003329 NlpC/P60 family; Region: NLPC_P60; cl17555 454169003330 Phage-related protein, tail component [Function unknown]; Region: COG4723 454169003331 Phage-related protein, tail component [Function unknown]; Region: COG4733 454169003332 Putative phage tail protein; Region: Phage-tail_3; pfam13550 454169003333 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 454169003334 Interdomain contacts; other site 454169003335 Cytokine receptor motif; other site 454169003336 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 454169003337 Fibronectin type III protein; Region: DUF3672; pfam12421 454169003338 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 454169003339 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 454169003340 Phage Tail Collar Domain; Region: Collar; pfam07484 454169003341 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 454169003342 ADP-ribose binding site [chemical binding]; other site 454169003343 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454169003344 type III secretion protein SopE; Provisional; Region: PRK15279 454169003345 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 454169003346 SopE GEF domain; Region: SopE_GEF; pfam07487 454169003347 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 454169003348 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 454169003349 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 454169003350 DNA-binding interface [nucleotide binding]; DNA binding site 454169003351 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 454169003352 Transposase; Region: DDE_Tnp_ISL3; pfam01610 454169003353 aminopeptidase N; Provisional; Region: pepN; PRK14015 454169003354 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 454169003355 active site 454169003356 Zn binding site [ion binding]; other site 454169003357 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 454169003358 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 454169003359 quinone interaction residues [chemical binding]; other site 454169003360 active site 454169003361 catalytic residues [active] 454169003362 FMN binding site [chemical binding]; other site 454169003363 substrate binding site [chemical binding]; other site 454169003364 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 454169003365 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 454169003366 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 454169003367 MOSC domain; Region: MOSC; pfam03473 454169003368 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 454169003369 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454169003370 catalytic loop [active] 454169003371 iron binding site [ion binding]; other site 454169003372 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 454169003373 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 454169003374 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 454169003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169003376 S-adenosylmethionine binding site [chemical binding]; other site 454169003377 ABC transporter ATPase component; Reviewed; Region: PRK11147 454169003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169003379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169003380 Walker A/P-loop; other site 454169003381 Walker A/P-loop; other site 454169003382 ATP binding site [chemical binding]; other site 454169003383 ATP binding site [chemical binding]; other site 454169003384 Q-loop/lid; other site 454169003385 Q-loop/lid; other site 454169003386 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169003387 ABC transporter signature motif; other site 454169003388 Walker B; other site 454169003389 D-loop; other site 454169003390 ABC transporter; Region: ABC_tran_2; pfam12848 454169003391 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169003392 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 454169003393 Paraquat-inducible protein A; Region: PqiA; pfam04403 454169003394 Paraquat-inducible protein A; Region: PqiA; pfam04403 454169003395 paraquat-inducible protein B; Provisional; Region: PRK10807 454169003396 mce related protein; Region: MCE; pfam02470 454169003397 mce related protein; Region: MCE; pfam02470 454169003398 mce related protein; Region: MCE; pfam02470 454169003399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 454169003400 Protein of unknown function (DUF330); Region: DUF330; pfam03886 454169003401 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 454169003402 active site 1 [active] 454169003403 dimer interface [polypeptide binding]; other site 454169003404 active site 2 [active] 454169003405 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 454169003406 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 454169003407 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 454169003408 outer membrane protein A; Reviewed; Region: PRK10808 454169003409 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 454169003410 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454169003411 ligand binding site [chemical binding]; other site 454169003412 cell division inhibitor SulA; Region: sula; TIGR00623 454169003413 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 454169003414 TfoX C-terminal domain; Region: TfoX_C; pfam04994 454169003415 TIGR01666 family membrane protein; Region: YCCS 454169003416 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 454169003417 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454169003418 Predicted membrane protein [Function unknown]; Region: COG3304 454169003419 Domain of unknown function (DUF307); Region: DUF307; pfam03733 454169003420 Domain of unknown function (DUF307); Region: DUF307; pfam03733 454169003421 DNA helicase IV; Provisional; Region: helD; PRK11054 454169003422 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 454169003423 Part of AAA domain; Region: AAA_19; pfam13245 454169003424 Family description; Region: UvrD_C_2; pfam13538 454169003425 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 454169003426 active site 454169003427 dimer interfaces [polypeptide binding]; other site 454169003428 catalytic residues [active] 454169003429 hypothetical protein; Provisional; Region: PRK03641 454169003430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 454169003431 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 454169003432 heat shock protein HspQ; Provisional; Region: PRK14129 454169003433 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 454169003434 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 454169003435 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 454169003436 putative RNA binding site [nucleotide binding]; other site 454169003437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169003438 S-adenosylmethionine binding site [chemical binding]; other site 454169003439 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 454169003440 substrate binding site [chemical binding]; other site 454169003441 Cupin domain; Region: Cupin_2; cl17218 454169003442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169003443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169003444 acylphosphatase; Provisional; Region: PRK14426 454169003445 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 454169003446 sulfur transfer protein TusE; Provisional; Region: PRK11508 454169003447 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454169003448 YccA-like proteins; Region: YccA_like; cd10433 454169003449 PipA protein; Region: PipA; pfam07108 454169003450 secreted effector protein PipB; Provisional; Region: PRK15197 454169003451 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169003452 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169003453 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169003454 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 454169003455 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 454169003456 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 454169003457 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 454169003458 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 454169003459 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 454169003460 HAMP domain; Region: HAMP; pfam00672 454169003461 dimerization interface [polypeptide binding]; other site 454169003462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169003463 dimer interface [polypeptide binding]; other site 454169003464 phosphorylation site [posttranslational modification] 454169003465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169003466 ATP binding site [chemical binding]; other site 454169003467 Mg2+ binding site [ion binding]; other site 454169003468 G-X-G motif; other site 454169003469 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 454169003470 active site 454169003471 homotetramer interface [polypeptide binding]; other site 454169003472 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 454169003473 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 454169003474 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 454169003475 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 454169003476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454169003477 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 454169003478 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 454169003479 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 454169003480 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 454169003481 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 454169003482 NAD binding site [chemical binding]; other site 454169003483 catalytic residues [active] 454169003484 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 454169003485 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 454169003486 putative active site [active] 454169003487 putative metal binding site [ion binding]; other site 454169003488 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 454169003489 putative substrate binding pocket [chemical binding]; other site 454169003490 trimer interface [polypeptide binding]; other site 454169003491 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 454169003492 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 454169003493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169003494 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 454169003495 putative substrate translocation pore; other site 454169003496 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 454169003497 Cupin domain; Region: Cupin_2; pfam07883 454169003498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169003499 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 454169003500 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 454169003501 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 454169003502 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 454169003503 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 454169003504 HSP70 interaction site [polypeptide binding]; other site 454169003505 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 454169003506 substrate binding site [polypeptide binding]; other site 454169003507 dimer interface [polypeptide binding]; other site 454169003508 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 454169003509 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 454169003510 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 454169003511 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 454169003512 DsbD alpha interface [polypeptide binding]; other site 454169003513 catalytic residues [active] 454169003514 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 454169003515 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 454169003516 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454169003517 catalytic residues [active] 454169003518 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 454169003519 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 454169003520 catalytic residues [active] 454169003521 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 454169003522 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 454169003523 catalytic core [active] 454169003524 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 454169003525 hypothetical protein; Provisional; Region: PRK10174 454169003526 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 454169003527 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 454169003528 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 454169003529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169003530 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 454169003531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 454169003532 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 454169003533 Predicted transcriptional regulator [Transcription]; Region: COG3905 454169003534 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 454169003535 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 454169003536 Glutamate binding site [chemical binding]; other site 454169003537 NAD binding site [chemical binding]; other site 454169003538 catalytic residues [active] 454169003539 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 454169003540 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 454169003541 Na binding site [ion binding]; other site 454169003542 hypothetical protein; Provisional; Region: PRK10536 454169003543 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 454169003544 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 454169003545 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 454169003546 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 454169003547 putative active site [active] 454169003548 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 454169003549 Na binding site [ion binding]; other site 454169003550 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 454169003551 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 454169003552 putative active site cavity [active] 454169003553 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 454169003554 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 454169003555 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 454169003556 putative sialic acid transporter; Provisional; Region: PRK12307 454169003557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169003558 putative substrate translocation pore; other site 454169003559 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454169003560 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454169003561 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454169003562 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 454169003563 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 454169003564 putative ligand binding site [chemical binding]; other site 454169003565 NAD binding site [chemical binding]; other site 454169003566 dimerization interface [polypeptide binding]; other site 454169003567 catalytic site [active] 454169003568 putative hydrolase; Validated; Region: PRK09248 454169003569 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 454169003570 active site 454169003571 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 454169003572 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 454169003573 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 454169003574 curli assembly protein CsgF; Provisional; Region: PRK10050 454169003575 curli assembly protein CsgE; Provisional; Region: PRK10386 454169003576 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 454169003577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169003578 DNA binding residues [nucleotide binding] 454169003579 dimerization interface [polypeptide binding]; other site 454169003580 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 454169003581 Curlin associated repeat; Region: Curlin_rpt; pfam07012 454169003582 Curlin associated repeat; Region: Curlin_rpt; pfam07012 454169003583 major curlin subunit; Provisional; Region: csgA; PRK10051 454169003584 Curlin associated repeat; Region: Curlin_rpt; pfam07012 454169003585 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 454169003586 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 454169003587 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 454169003588 putative ADP-ribose binding site [chemical binding]; other site 454169003589 putative active site [active] 454169003590 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 454169003591 PLD-like domain; Region: PLDc_2; pfam13091 454169003592 putative active site [active] 454169003593 catalytic site [active] 454169003594 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 454169003595 PLD-like domain; Region: PLDc_2; pfam13091 454169003596 putative active site [active] 454169003597 catalytic site [active] 454169003598 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 454169003599 Acyltransferase family; Region: Acyl_transf_3; pfam01757 454169003600 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 454169003601 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 454169003602 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454169003603 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 454169003604 Ligand binding site; other site 454169003605 DXD motif; other site 454169003606 lipoprotein; Provisional; Region: PRK10175 454169003607 secY/secA suppressor protein; Provisional; Region: PRK11467 454169003608 drug efflux system protein MdtG; Provisional; Region: PRK09874 454169003609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169003610 putative substrate translocation pore; other site 454169003611 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 454169003612 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 454169003613 putative acyl-acceptor binding pocket; other site 454169003614 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 454169003615 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 454169003616 active site residue [active] 454169003617 hypothetical protein; Provisional; Region: PRK03757 454169003618 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 454169003619 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 454169003620 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 454169003621 hydroxyglutarate oxidase; Provisional; Region: PRK11728 454169003622 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 454169003623 DNA damage-inducible protein I; Provisional; Region: PRK10597 454169003624 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 454169003625 active site 454169003626 substrate binding pocket [chemical binding]; other site 454169003627 dimer interface [polypeptide binding]; other site 454169003628 lipoprotein; Provisional; Region: PRK10598 454169003629 glutaredoxin 2; Provisional; Region: PRK10387 454169003630 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 454169003631 C-terminal domain interface [polypeptide binding]; other site 454169003632 GSH binding site (G-site) [chemical binding]; other site 454169003633 catalytic residues [active] 454169003634 putative dimer interface [polypeptide binding]; other site 454169003635 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 454169003636 N-terminal domain interface [polypeptide binding]; other site 454169003637 multidrug resistance protein MdtH; Provisional; Region: PRK11646 454169003638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169003639 putative substrate translocation pore; other site 454169003640 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 454169003641 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 454169003642 hypothetical protein; Provisional; Region: PRK11239 454169003643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 454169003644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454169003645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454169003646 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454169003647 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 454169003648 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 454169003649 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 454169003650 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 454169003651 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 454169003652 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 454169003653 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 454169003654 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 454169003655 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 454169003656 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 454169003657 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454169003658 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 454169003659 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 454169003660 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 454169003661 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 454169003662 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 454169003663 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454169003664 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 454169003665 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 454169003666 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 454169003667 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454169003668 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 454169003669 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 454169003670 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454169003671 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 454169003672 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 454169003673 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 454169003674 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 454169003675 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 454169003676 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 454169003677 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 454169003678 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 454169003679 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 454169003680 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 454169003681 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 454169003682 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 454169003683 ribonuclease E; Reviewed; Region: rne; PRK10811 454169003684 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 454169003685 homodimer interface [polypeptide binding]; other site 454169003686 oligonucleotide binding site [chemical binding]; other site 454169003687 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 454169003688 RNase E 5' UTR element 454169003689 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 454169003690 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169003691 RNA binding surface [nucleotide binding]; other site 454169003692 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 454169003693 active site 454169003694 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 454169003695 Maf-like protein; Region: Maf; pfam02545 454169003696 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 454169003697 active site 454169003698 dimer interface [polypeptide binding]; other site 454169003699 hypothetical protein; Provisional; Region: PRK11193 454169003700 putative phosphate acyltransferase; Provisional; Region: PRK05331 454169003701 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 454169003702 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 454169003703 dimer interface [polypeptide binding]; other site 454169003704 active site 454169003705 CoA binding pocket [chemical binding]; other site 454169003706 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 454169003707 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 454169003708 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 454169003709 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 454169003710 NAD(P) binding site [chemical binding]; other site 454169003711 homotetramer interface [polypeptide binding]; other site 454169003712 homodimer interface [polypeptide binding]; other site 454169003713 active site 454169003714 acyl carrier protein; Provisional; Region: acpP; PRK00982 454169003715 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 454169003716 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 454169003717 dimer interface [polypeptide binding]; other site 454169003718 active site 454169003719 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 454169003720 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 454169003721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169003722 catalytic residue [active] 454169003723 conserved hypothetical protein, YceG family; Region: TIGR00247 454169003724 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 454169003725 dimerization interface [polypeptide binding]; other site 454169003726 thymidylate kinase; Validated; Region: tmk; PRK00698 454169003727 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 454169003728 TMP-binding site; other site 454169003729 ATP-binding site [chemical binding]; other site 454169003730 DNA polymerase III subunit delta'; Validated; Region: PRK07993 454169003731 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 454169003732 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 454169003733 active site 454169003734 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 454169003735 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454169003736 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454169003737 active site turn [active] 454169003738 phosphorylation site [posttranslational modification] 454169003739 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 454169003740 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169003741 N-terminal plug; other site 454169003742 ligand-binding site [chemical binding]; other site 454169003743 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 454169003744 nucleotide binding site/active site [active] 454169003745 HIT family signature motif; other site 454169003746 catalytic residue [active] 454169003747 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 454169003748 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 454169003749 putative dimer interface [polypeptide binding]; other site 454169003750 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 454169003751 thiamine kinase; Region: ycfN_thiK; TIGR02721 454169003752 thiamine kinase; Provisional; Region: thiK; PRK10271 454169003753 substrate binding site [chemical binding]; other site 454169003754 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 454169003755 beta-hexosaminidase; Provisional; Region: PRK05337 454169003756 hypothetical protein; Provisional; Region: PRK04940 454169003757 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 454169003758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169003759 hypothetical protein; Provisional; Region: PRK11280 454169003760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454169003761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169003762 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169003763 L,D-transpeptidase; Provisional; Region: PRK10190 454169003764 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169003765 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169003766 transcription-repair coupling factor; Provisional; Region: PRK10689 454169003767 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 454169003768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169003769 ATP binding site [chemical binding]; other site 454169003770 putative Mg++ binding site [ion binding]; other site 454169003771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169003772 nucleotide binding region [chemical binding]; other site 454169003773 ATP-binding site [chemical binding]; other site 454169003774 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 454169003775 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 454169003776 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 454169003777 FtsX-like permease family; Region: FtsX; pfam02687 454169003778 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 454169003779 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 454169003780 Walker A/P-loop; other site 454169003781 ATP binding site [chemical binding]; other site 454169003782 Q-loop/lid; other site 454169003783 ABC transporter signature motif; other site 454169003784 Walker B; other site 454169003785 D-loop; other site 454169003786 H-loop/switch region; other site 454169003787 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 454169003788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 454169003789 FtsX-like permease family; Region: FtsX; pfam02687 454169003790 fructokinase; Reviewed; Region: PRK09557 454169003791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169003792 nucleotide binding site [chemical binding]; other site 454169003793 NAD-dependent deacetylase; Provisional; Region: PRK00481 454169003794 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 454169003795 NAD+ binding site [chemical binding]; other site 454169003796 substrate binding site [chemical binding]; other site 454169003797 Zn binding site [ion binding]; other site 454169003798 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 454169003799 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 454169003800 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 454169003801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169003802 dimer interface [polypeptide binding]; other site 454169003803 conserved gate region; other site 454169003804 putative PBP binding loops; other site 454169003805 ABC-ATPase subunit interface; other site 454169003806 Sif protein; Region: Sif; pfam06767 454169003807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 454169003808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169003809 dimer interface [polypeptide binding]; other site 454169003810 conserved gate region; other site 454169003811 putative PBP binding loops; other site 454169003812 ABC-ATPase subunit interface; other site 454169003813 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 454169003814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169003815 Walker A/P-loop; other site 454169003816 ATP binding site [chemical binding]; other site 454169003817 Q-loop/lid; other site 454169003818 ABC transporter signature motif; other site 454169003819 Walker B; other site 454169003820 D-loop; other site 454169003821 H-loop/switch region; other site 454169003822 TOBE domain; Region: TOBE_2; pfam08402 454169003823 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 454169003824 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 454169003825 metal binding site [ion binding]; metal-binding site 454169003826 dimer interface [polypeptide binding]; other site 454169003827 Uncharacterized conserved protein [Function unknown]; Region: COG2850 454169003828 Cupin-like domain; Region: Cupin_8; pfam13621 454169003829 sensor protein PhoQ; Provisional; Region: PRK10815 454169003830 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 454169003831 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 454169003832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169003833 ATP binding site [chemical binding]; other site 454169003834 Mg2+ binding site [ion binding]; other site 454169003835 G-X-G motif; other site 454169003836 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 454169003837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169003838 active site 454169003839 phosphorylation site [posttranslational modification] 454169003840 intermolecular recognition site; other site 454169003841 dimerization interface [polypeptide binding]; other site 454169003842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169003843 DNA binding site [nucleotide binding] 454169003844 adenylosuccinate lyase; Provisional; Region: PRK09285 454169003845 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 454169003846 tetramer interface [polypeptide binding]; other site 454169003847 active site 454169003848 putative lysogenization regulator; Reviewed; Region: PRK00218 454169003849 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 454169003850 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 454169003851 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 454169003852 nudix motif; other site 454169003853 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 454169003854 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 454169003855 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 454169003856 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 454169003857 probable active site [active] 454169003858 isocitrate dehydrogenase; Validated; Region: PRK07362 454169003859 isocitrate dehydrogenase; Reviewed; Region: PRK07006 454169003860 Transposase IS200 like; Region: Y1_Tnp; pfam01797 454169003861 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 454169003862 DinI-like family; Region: DinI; pfam06183 454169003863 Ricin-type beta-trefoil; Region: RICIN; smart00458 454169003864 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 454169003865 putative sugar binding sites [chemical binding]; other site 454169003866 Q-X-W motif; other site 454169003867 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 454169003868 lysozyme inhibitor; Provisional; Region: PRK13791 454169003869 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 454169003870 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 454169003871 putative dimer interface [polypeptide binding]; other site 454169003872 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 454169003873 BNR repeat-like domain; Region: BNR_2; pfam13088 454169003874 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 454169003875 TRL-like protein family; Region: TRL; pfam13146 454169003876 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 454169003877 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 454169003878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 454169003879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169003880 dimer interface [polypeptide binding]; other site 454169003881 conserved gate region; other site 454169003882 ABC-ATPase subunit interface; other site 454169003883 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 454169003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169003885 dimer interface [polypeptide binding]; other site 454169003886 conserved gate region; other site 454169003887 putative PBP binding loops; other site 454169003888 ABC-ATPase subunit interface; other site 454169003889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169003890 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 454169003891 Walker A/P-loop; other site 454169003892 ATP binding site [chemical binding]; other site 454169003893 Q-loop/lid; other site 454169003894 ABC transporter signature motif; other site 454169003895 Walker B; other site 454169003896 D-loop; other site 454169003897 H-loop/switch region; other site 454169003898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169003899 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 454169003900 Walker A/P-loop; other site 454169003901 ATP binding site [chemical binding]; other site 454169003902 Q-loop/lid; other site 454169003903 ABC transporter signature motif; other site 454169003904 Walker B; other site 454169003905 D-loop; other site 454169003906 H-loop/switch region; other site 454169003907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 454169003908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169003909 zinc/cadmium-binding protein; Provisional; Region: PRK10306 454169003910 aminoglycoside resistance protein; Provisional; Region: PRK13746 454169003911 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 454169003912 active site 454169003913 NTP binding site [chemical binding]; other site 454169003914 metal binding triad [ion binding]; metal-binding site 454169003915 antibiotic binding site [chemical binding]; other site 454169003916 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 454169003917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169003918 DNA binding residues [nucleotide binding] 454169003919 transcriptional regulator MirA; Provisional; Region: PRK15043 454169003920 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 454169003921 DNA binding residues [nucleotide binding] 454169003922 dimer interface [polypeptide binding]; other site 454169003923 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 454169003924 chorismate mutase; Provisional; Region: PRK08055 454169003925 leucine export protein LeuE; Provisional; Region: PRK10958 454169003926 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 454169003927 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 454169003928 Phage Tail Collar Domain; Region: Collar; pfam07484 454169003929 hypothetical protein; Provisional; Region: PRK10457 454169003930 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 454169003931 murein hydrolase B; Provisional; Region: PRK10760; cl17906 454169003932 Domain of unknown function (DUF333); Region: DUF333; pfam03891 454169003933 Uncharacterized conserved protein [Function unknown]; Region: COG3189 454169003934 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 454169003935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169003936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169003937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169003938 Predicted membrane protein [Function unknown]; Region: COG2707 454169003939 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 454169003940 putative deacylase active site [active] 454169003941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454169003942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169003943 metal binding site [ion binding]; metal-binding site 454169003944 active site 454169003945 I-site; other site 454169003946 hypothetical protein; Provisional; Region: PRK05325 454169003947 PrkA family serine protein kinase; Provisional; Region: PRK15455 454169003948 AAA ATPase domain; Region: AAA_16; pfam13191 454169003949 Walker A motif; other site 454169003950 ATP binding site [chemical binding]; other site 454169003951 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 454169003952 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 454169003953 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454169003954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169003955 FeS/SAM binding site; other site 454169003956 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454169003957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169003958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169003959 active site 454169003960 catalytic tetrad [active] 454169003961 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 454169003962 active site 454169003963 phosphate binding residues; other site 454169003964 catalytic residues [active] 454169003965 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 454169003966 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 454169003967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 454169003968 methionine sulfoxide reductase B; Provisional; Region: PRK00222 454169003969 SelR domain; Region: SelR; pfam01641 454169003970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 454169003971 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 454169003972 Isochorismatase family; Region: Isochorismatase; pfam00857 454169003973 catalytic triad [active] 454169003974 metal binding site [ion binding]; metal-binding site 454169003975 conserved cis-peptide bond; other site 454169003976 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 454169003977 active site 454169003978 homodimer interface [polypeptide binding]; other site 454169003979 protease 4; Provisional; Region: PRK10949 454169003980 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 454169003981 tandem repeat interface [polypeptide binding]; other site 454169003982 oligomer interface [polypeptide binding]; other site 454169003983 active site residues [active] 454169003984 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 454169003985 tandem repeat interface [polypeptide binding]; other site 454169003986 oligomer interface [polypeptide binding]; other site 454169003987 active site residues [active] 454169003988 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 454169003989 putative FMN binding site [chemical binding]; other site 454169003990 selenophosphate synthetase; Provisional; Region: PRK00943 454169003991 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 454169003992 dimerization interface [polypeptide binding]; other site 454169003993 putative ATP binding site [chemical binding]; other site 454169003994 DNA topoisomerase III; Provisional; Region: PRK07726 454169003995 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 454169003996 active site 454169003997 putative interdomain interaction site [polypeptide binding]; other site 454169003998 putative metal-binding site [ion binding]; other site 454169003999 putative nucleotide binding site [chemical binding]; other site 454169004000 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 454169004001 domain I; other site 454169004002 DNA binding groove [nucleotide binding] 454169004003 phosphate binding site [ion binding]; other site 454169004004 domain II; other site 454169004005 domain III; other site 454169004006 nucleotide binding site [chemical binding]; other site 454169004007 catalytic site [active] 454169004008 domain IV; other site 454169004009 glutamate dehydrogenase; Provisional; Region: PRK09414 454169004010 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 454169004011 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 454169004012 NAD(P) binding site [chemical binding]; other site 454169004013 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 454169004014 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 454169004015 active site 454169004016 8-oxo-dGMP binding site [chemical binding]; other site 454169004017 nudix motif; other site 454169004018 metal binding site [ion binding]; metal-binding site 454169004019 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 454169004020 putative catalytic site [active] 454169004021 putative phosphate binding site [ion binding]; other site 454169004022 active site 454169004023 metal binding site A [ion binding]; metal-binding site 454169004024 DNA binding site [nucleotide binding] 454169004025 putative AP binding site [nucleotide binding]; other site 454169004026 putative metal binding site B [ion binding]; other site 454169004027 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 454169004028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454169004029 inhibitor-cofactor binding pocket; inhibition site 454169004030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169004031 catalytic residue [active] 454169004032 arginine succinyltransferase; Provisional; Region: PRK10456 454169004033 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 454169004034 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 454169004035 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 454169004036 NAD(P) binding site [chemical binding]; other site 454169004037 catalytic residues [active] 454169004038 succinylarginine dihydrolase; Provisional; Region: PRK13281 454169004039 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 454169004040 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 454169004041 putative active site [active] 454169004042 Zn binding site [ion binding]; other site 454169004043 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454169004044 dimer interface [polypeptide binding]; other site 454169004045 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 454169004046 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 454169004047 GIY-YIG motif/motif A; other site 454169004048 active site 454169004049 catalytic site [active] 454169004050 putative DNA binding site [nucleotide binding]; other site 454169004051 metal binding site [ion binding]; metal-binding site 454169004052 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 454169004053 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 454169004054 homodimer interface [polypeptide binding]; other site 454169004055 NAD binding pocket [chemical binding]; other site 454169004056 ATP binding pocket [chemical binding]; other site 454169004057 Mg binding site [ion binding]; other site 454169004058 active-site loop [active] 454169004059 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 454169004060 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 454169004061 active site 454169004062 P-loop; other site 454169004063 phosphorylation site [posttranslational modification] 454169004064 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 454169004065 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 454169004066 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 454169004067 methionine cluster; other site 454169004068 active site 454169004069 phosphorylation site [posttranslational modification] 454169004070 metal binding site [ion binding]; metal-binding site 454169004071 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 454169004072 Cupin domain; Region: Cupin_2; pfam07883 454169004073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169004074 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 454169004075 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 454169004076 NAD binding site [chemical binding]; other site 454169004077 sugar binding site [chemical binding]; other site 454169004078 divalent metal binding site [ion binding]; other site 454169004079 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454169004080 dimer interface [polypeptide binding]; other site 454169004081 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 454169004082 putative active site [active] 454169004083 YdjC motif; other site 454169004084 Mg binding site [ion binding]; other site 454169004085 putative homodimer interface [polypeptide binding]; other site 454169004086 hydroperoxidase II; Provisional; Region: katE; PRK11249 454169004087 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 454169004088 tetramer interface [polypeptide binding]; other site 454169004089 heme binding pocket [chemical binding]; other site 454169004090 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 454169004091 domain interactions; other site 454169004092 cell division modulator; Provisional; Region: PRK10113 454169004093 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 454169004094 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454169004095 inner membrane protein; Provisional; Region: PRK11648 454169004096 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 454169004097 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 454169004098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169004099 motif II; other site 454169004100 YniB-like protein; Region: YniB; pfam14002 454169004101 Phosphotransferase enzyme family; Region: APH; pfam01636 454169004102 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 454169004103 active site 454169004104 ATP binding site [chemical binding]; other site 454169004105 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 454169004106 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 454169004107 6-phosphofructokinase 2; Provisional; Region: PRK10294 454169004108 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 454169004109 putative substrate binding site [chemical binding]; other site 454169004110 putative ATP binding site [chemical binding]; other site 454169004111 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 454169004112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 454169004113 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 454169004114 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 454169004115 active site 454169004116 substrate binding site [chemical binding]; other site 454169004117 Mg2+ binding site [ion binding]; other site 454169004118 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 454169004119 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 454169004120 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 454169004121 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 454169004122 active site 454169004123 dimer interface [polypeptide binding]; other site 454169004124 motif 1; other site 454169004125 motif 2; other site 454169004126 motif 3; other site 454169004127 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 454169004128 anticodon binding site; other site 454169004129 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 454169004130 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 454169004131 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 454169004132 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 454169004133 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 454169004134 23S rRNA binding site [nucleotide binding]; other site 454169004135 L21 binding site [polypeptide binding]; other site 454169004136 L13 binding site [polypeptide binding]; other site 454169004137 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 454169004138 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 454169004139 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 454169004140 dimer interface [polypeptide binding]; other site 454169004141 motif 1; other site 454169004142 active site 454169004143 motif 2; other site 454169004144 motif 3; other site 454169004145 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 454169004146 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 454169004147 putative tRNA-binding site [nucleotide binding]; other site 454169004148 B3/4 domain; Region: B3_4; pfam03483 454169004149 tRNA synthetase B5 domain; Region: B5; smart00874 454169004150 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 454169004151 dimer interface [polypeptide binding]; other site 454169004152 motif 1; other site 454169004153 motif 3; other site 454169004154 motif 2; other site 454169004155 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 454169004156 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454169004157 IHF dimer interface [polypeptide binding]; other site 454169004158 IHF - DNA interface [nucleotide binding]; other site 454169004159 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454169004160 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169004161 ABC-ATPase subunit interface; other site 454169004162 dimer interface [polypeptide binding]; other site 454169004163 putative PBP binding regions; other site 454169004164 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 454169004165 catalytic residues [active] 454169004166 dimer interface [polypeptide binding]; other site 454169004167 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 454169004168 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454169004169 Walker A/P-loop; other site 454169004170 ATP binding site [chemical binding]; other site 454169004171 Q-loop/lid; other site 454169004172 ABC transporter signature motif; other site 454169004173 Walker B; other site 454169004174 D-loop; other site 454169004175 H-loop/switch region; other site 454169004176 NlpC/P60 family; Region: NLPC_P60; pfam00877 454169004177 Uncharacterized conserved protein [Function unknown]; Region: COG0397 454169004178 hypothetical protein; Validated; Region: PRK00029 454169004179 hypothetical protein; Provisional; Region: PRK10183 454169004180 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 454169004181 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454169004182 PEP synthetase regulatory protein; Provisional; Region: PRK05339 454169004183 phosphoenolpyruvate synthase; Validated; Region: PRK06464 454169004184 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 454169004185 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 454169004186 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 454169004187 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 454169004188 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 454169004189 acyl-activating enzyme (AAE) consensus motif; other site 454169004190 putative AMP binding site [chemical binding]; other site 454169004191 putative active site [active] 454169004192 putative CoA binding site [chemical binding]; other site 454169004193 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 454169004194 oxidoreductase; Provisional; Region: PRK10015 454169004195 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 454169004196 Electron transfer flavoprotein domain; Region: ETF; smart00893 454169004197 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 454169004198 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 454169004199 Ligand binding site [chemical binding]; other site 454169004200 Electron transfer flavoprotein domain; Region: ETF; pfam01012 454169004201 Cupin domain; Region: Cupin_2; pfam07883 454169004202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169004203 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 454169004204 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 454169004205 active site 454169004206 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 454169004207 Coenzyme A transferase; Region: CoA_trans; smart00882 454169004208 Coenzyme A transferase; Region: CoA_trans; cl17247 454169004209 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 454169004210 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 454169004211 active site 454169004212 catalytic residue [active] 454169004213 dimer interface [polypeptide binding]; other site 454169004214 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 454169004215 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 454169004216 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 454169004217 shikimate binding site; other site 454169004218 NAD(P) binding site [chemical binding]; other site 454169004219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169004221 putative substrate translocation pore; other site 454169004222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169004224 putative substrate translocation pore; other site 454169004225 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 454169004226 putative inner membrane protein; Provisional; Region: PRK10983 454169004227 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454169004228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 454169004229 FAD binding domain; Region: FAD_binding_4; pfam01565 454169004230 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 454169004231 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 454169004232 CoenzymeA binding site [chemical binding]; other site 454169004233 subunit interaction site [polypeptide binding]; other site 454169004234 PHB binding site; other site 454169004235 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 454169004236 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454169004237 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 454169004238 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 454169004239 putative ABC transporter; Region: ycf24; CHL00085 454169004240 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 454169004241 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 454169004242 Walker A/P-loop; other site 454169004243 ATP binding site [chemical binding]; other site 454169004244 Q-loop/lid; other site 454169004245 ABC transporter signature motif; other site 454169004246 Walker B; other site 454169004247 D-loop; other site 454169004248 H-loop/switch region; other site 454169004249 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 454169004250 FeS assembly protein SufD; Region: sufD; TIGR01981 454169004251 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 454169004252 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 454169004253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169004254 catalytic residue [active] 454169004255 cysteine desufuration protein SufE; Provisional; Region: PRK09296 454169004256 L,D-transpeptidase; Provisional; Region: PRK10190 454169004257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169004258 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169004259 murein lipoprotein; Provisional; Region: PRK15396 454169004260 murein lipoprotein; Provisional; Region: PRK15396 454169004261 pyruvate kinase; Provisional; Region: PRK09206 454169004262 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 454169004263 domain interfaces; other site 454169004264 active site 454169004265 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 454169004266 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 454169004267 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 454169004268 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169004269 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169004270 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169004271 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454169004272 substrate binding site [chemical binding]; other site 454169004273 dimer interface [polypeptide binding]; other site 454169004274 ATP binding site [chemical binding]; other site 454169004275 tetrathionate reductase subunit A; Provisional; Region: PRK14991 454169004276 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 454169004277 putative [Fe4-S4] binding site [ion binding]; other site 454169004278 putative molybdopterin cofactor binding site [chemical binding]; other site 454169004279 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 454169004280 putative molybdopterin cofactor binding site; other site 454169004281 tetrathionate reductase subunit C; Provisional; Region: PRK14992 454169004282 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 454169004283 tetrathionate reductase subunit B; Provisional; Region: PRK14993 454169004284 4Fe-4S binding domain; Region: Fer4; pfam00037 454169004285 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 454169004286 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 454169004287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 454169004288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169004289 dimer interface [polypeptide binding]; other site 454169004290 phosphorylation site [posttranslational modification] 454169004291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169004292 ATP binding site [chemical binding]; other site 454169004293 Mg2+ binding site [ion binding]; other site 454169004294 G-X-G motif; other site 454169004295 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 454169004296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169004297 active site 454169004298 phosphorylation site [posttranslational modification] 454169004299 intermolecular recognition site; other site 454169004300 dimerization interface [polypeptide binding]; other site 454169004301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169004302 DNA binding residues [nucleotide binding] 454169004303 dimerization interface [polypeptide binding]; other site 454169004304 hypothetical protein; Provisional; Region: PRK10292 454169004305 Uncharacterized conserved protein [Function unknown]; Region: COG1683 454169004306 Uncharacterized conserved protein [Function unknown]; Region: COG3272 454169004307 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 454169004308 transcriptional regulator MirA; Provisional; Region: PRK15043 454169004309 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 454169004310 DNA binding residues [nucleotide binding] 454169004311 two component system sensor kinase SsrB; Provisional; Region: PRK15369 454169004312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169004313 active site 454169004314 phosphorylation site [posttranslational modification] 454169004315 intermolecular recognition site; other site 454169004316 dimerization interface [polypeptide binding]; other site 454169004317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169004318 DNA binding residues [nucleotide binding] 454169004319 dimerization interface [polypeptide binding]; other site 454169004320 two component system sensor kinase SsrA; Provisional; Region: PRK15347 454169004321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169004322 dimerization interface [polypeptide binding]; other site 454169004323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169004324 dimer interface [polypeptide binding]; other site 454169004325 phosphorylation site [posttranslational modification] 454169004326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169004327 ATP binding site [chemical binding]; other site 454169004328 Mg2+ binding site [ion binding]; other site 454169004329 G-X-G motif; other site 454169004330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169004331 active site 454169004332 phosphorylation site [posttranslational modification] 454169004333 intermolecular recognition site; other site 454169004334 dimerization interface [polypeptide binding]; other site 454169004335 outer membrane secretin SsaC; Provisional; Region: PRK15346 454169004336 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 454169004337 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454169004338 type III secretion system protein SsaD; Provisional; Region: PRK15367 454169004339 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 454169004340 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 454169004341 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 454169004342 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 454169004343 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 454169004344 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 454169004345 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 454169004346 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 454169004347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454169004348 TPR motif; other site 454169004349 binding surface 454169004350 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 454169004351 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 454169004352 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 454169004353 type III secretion system protein SsaH; Provisional; Region: PRK15356 454169004354 type III secretion system protein SsaI; Provisional; Region: PRK15355 454169004355 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 454169004356 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 454169004357 type III secretion system protein SsaK; Provisional; Region: PRK15354 454169004358 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 454169004359 type III secretion system protein SsaL; Provisional; Region: PRK15345 454169004360 HrpJ-like domain; Region: HrpJ; pfam07201 454169004361 TyeA; Region: TyeA; cl07611 454169004362 type III secretion system protein SsaM; Provisional; Region: PRK15353 454169004363 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 454169004364 FHIPEP family; Region: FHIPEP; pfam00771 454169004365 type III secretion system ATPase SsaN; Validated; Region: PRK07594 454169004366 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454169004367 Walker A motif; other site 454169004368 ATP binding site [chemical binding]; other site 454169004369 Walker B motif; other site 454169004370 type III secretion system protein SsaO; Provisional; Region: PRK15352 454169004371 type III secretion system protein SsaP; Provisional; Region: PRK15351 454169004372 type III secretion system protein SsaQ; Validated; Region: PRK08035 454169004373 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 454169004374 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 454169004375 type III secretion system protein SsaS; Provisional; Region: PRK15350 454169004376 type III secretion system protein SsaT; Provisional; Region: PRK15349 454169004377 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 454169004378 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 454169004379 multidrug efflux protein; Reviewed; Region: PRK01766 454169004380 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 454169004381 cation binding site [ion binding]; other site 454169004382 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 454169004383 Lumazine binding domain; Region: Lum_binding; pfam00677 454169004384 Lumazine binding domain; Region: Lum_binding; pfam00677 454169004385 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 454169004386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169004387 S-adenosylmethionine binding site [chemical binding]; other site 454169004388 putative transporter; Provisional; Region: PRK11043 454169004389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004390 putative substrate translocation pore; other site 454169004391 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 454169004392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169004393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169004394 dimerization interface [polypeptide binding]; other site 454169004395 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 454169004396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169004397 DNA binding site [nucleotide binding] 454169004398 domain linker motif; other site 454169004399 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 454169004400 dimerization interface [polypeptide binding]; other site 454169004401 ligand binding site [chemical binding]; other site 454169004402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 454169004403 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 454169004404 Integrase core domain; Region: rve; pfam00665 454169004405 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 454169004406 multiple promoter invertase; Provisional; Region: mpi; PRK13413 454169004407 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 454169004408 catalytic residues [active] 454169004409 catalytic nucleophile [active] 454169004410 Presynaptic Site I dimer interface [polypeptide binding]; other site 454169004411 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 454169004412 Synaptic Flat tetramer interface [polypeptide binding]; other site 454169004413 Synaptic Site I dimer interface [polypeptide binding]; other site 454169004414 DNA binding site [nucleotide binding] 454169004415 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 454169004416 DNA-binding interface [nucleotide binding]; DNA binding site 454169004417 putative transposase OrfB; Reviewed; Region: PHA02517 454169004418 HTH-like domain; Region: HTH_21; pfam13276 454169004419 Integrase core domain; Region: rve; pfam00665 454169004420 Integrase core domain; Region: rve_2; pfam13333 454169004421 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 454169004422 Phosphotransferase enzyme family; Region: APH; pfam01636 454169004423 active site 454169004424 ATP binding site [chemical binding]; other site 454169004425 antibiotic binding site [chemical binding]; other site 454169004426 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 454169004427 Staphylococcal nuclease homologues; Region: SNc; smart00318 454169004428 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 454169004429 Catalytic site; other site 454169004430 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 454169004431 active site 454169004432 putative interdomain interaction site [polypeptide binding]; other site 454169004433 putative metal-binding site [ion binding]; other site 454169004434 putative nucleotide binding site [chemical binding]; other site 454169004435 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 454169004436 domain I; other site 454169004437 DNA binding groove [nucleotide binding] 454169004438 phosphate binding site [ion binding]; other site 454169004439 domain III; other site 454169004440 catalytic site [active] 454169004441 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 454169004442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 454169004443 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 454169004444 Integrase core domain; Region: rve; pfam00665 454169004445 multiple promoter invertase; Provisional; Region: mpi; PRK13413 454169004446 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 454169004447 catalytic residues [active] 454169004448 catalytic nucleophile [active] 454169004449 Presynaptic Site I dimer interface [polypeptide binding]; other site 454169004450 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 454169004451 Synaptic Flat tetramer interface [polypeptide binding]; other site 454169004452 Synaptic Site I dimer interface [polypeptide binding]; other site 454169004453 DNA binding site [nucleotide binding] 454169004454 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 454169004455 beta-lactamase TEM; Provisional; Region: PRK15442 454169004456 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 454169004457 transposase/IS protein; Provisional; Region: PRK09183 454169004458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169004459 Walker A motif; other site 454169004460 ATP binding site [chemical binding]; other site 454169004461 Walker B motif; other site 454169004462 arginine finger; other site 454169004463 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 454169004464 dihydropteroate synthase; Region: DHPS; TIGR01496 454169004465 substrate binding pocket [chemical binding]; other site 454169004466 dimer interface [polypeptide binding]; other site 454169004467 inhibitor binding site; inhibition site 454169004468 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 454169004469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 454169004470 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 454169004471 Integrase core domain; Region: rve; pfam00665 454169004472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169004473 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 454169004474 Walker A motif; other site 454169004475 ATP binding site [chemical binding]; other site 454169004476 Walker B motif; other site 454169004477 arginine finger; other site 454169004478 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 454169004479 active site 454169004480 catalytic triad [active] 454169004481 Integrase; Region: Integrase_1; pfam12835 454169004482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169004483 ATP binding site [chemical binding]; other site 454169004484 putative Mg++ binding site [ion binding]; other site 454169004485 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 454169004486 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 454169004487 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 454169004488 Replicase family; Region: Replicase; pfam03090 454169004489 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 454169004490 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 454169004491 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 454169004492 Int/Topo IB signature motif; other site 454169004493 superoxide dismutase; Provisional; Region: PRK10543 454169004494 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 454169004495 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 454169004496 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 454169004497 NlpC/P60 family; Region: NLPC_P60; pfam00877 454169004498 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 454169004499 putative GSH binding site [chemical binding]; other site 454169004500 catalytic residues [active] 454169004501 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 454169004502 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 454169004503 dimer interface [polypeptide binding]; other site 454169004504 catalytic site [active] 454169004505 putative active site [active] 454169004506 putative substrate binding site [chemical binding]; other site 454169004507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454169004508 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 454169004509 dimer interface [polypeptide binding]; other site 454169004510 active site 454169004511 metal binding site [ion binding]; metal-binding site 454169004512 glutathione binding site [chemical binding]; other site 454169004513 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 454169004514 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 454169004515 FMN binding site [chemical binding]; other site 454169004516 active site 454169004517 substrate binding site [chemical binding]; other site 454169004518 catalytic residue [active] 454169004519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454169004520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169004521 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 454169004522 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169004523 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169004524 active site 454169004525 catalytic tetrad [active] 454169004526 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 454169004527 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 454169004528 E-class dimer interface [polypeptide binding]; other site 454169004529 P-class dimer interface [polypeptide binding]; other site 454169004530 active site 454169004531 Cu2+ binding site [ion binding]; other site 454169004532 Zn2+ binding site [ion binding]; other site 454169004533 Fusaric acid resistance protein family; Region: FUSC; pfam04632 454169004534 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454169004535 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 454169004536 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169004537 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169004538 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 454169004539 transcriptional regulator SlyA; Provisional; Region: PRK03573 454169004540 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 454169004541 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 454169004542 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 454169004543 lysozyme inhibitor; Provisional; Region: PRK11372 454169004544 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 454169004545 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 454169004546 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 454169004547 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 454169004548 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 454169004549 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 454169004550 active site 454169004551 HIGH motif; other site 454169004552 dimer interface [polypeptide binding]; other site 454169004553 KMSKS motif; other site 454169004554 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169004555 RNA binding surface [nucleotide binding]; other site 454169004556 pyridoxamine kinase; Validated; Region: PRK05756 454169004557 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 454169004558 dimer interface [polypeptide binding]; other site 454169004559 pyridoxal binding site [chemical binding]; other site 454169004560 ATP binding site [chemical binding]; other site 454169004561 glutathionine S-transferase; Provisional; Region: PRK10542 454169004562 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 454169004563 C-terminal domain interface [polypeptide binding]; other site 454169004564 GSH binding site (G-site) [chemical binding]; other site 454169004565 dimer interface [polypeptide binding]; other site 454169004566 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 454169004567 dimer interface [polypeptide binding]; other site 454169004568 N-terminal domain interface [polypeptide binding]; other site 454169004569 substrate binding pocket (H-site) [chemical binding]; other site 454169004570 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 454169004571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004572 putative substrate translocation pore; other site 454169004573 POT family; Region: PTR2; pfam00854 454169004574 endonuclease III; Provisional; Region: PRK10702 454169004575 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 454169004576 minor groove reading motif; other site 454169004577 helix-hairpin-helix signature motif; other site 454169004578 substrate binding pocket [chemical binding]; other site 454169004579 active site 454169004580 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 454169004581 electron transport complex RsxE subunit; Provisional; Region: PRK12405 454169004582 electron transport complex protein RnfG; Validated; Region: PRK01908 454169004583 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 454169004584 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 454169004585 SLBB domain; Region: SLBB; pfam10531 454169004586 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169004587 electron transport complex protein RnfB; Provisional; Region: PRK05113 454169004588 Putative Fe-S cluster; Region: FeS; cl17515 454169004589 4Fe-4S binding domain; Region: Fer4; pfam00037 454169004590 electron transport complex protein RsxA; Provisional; Region: PRK05151 454169004591 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 454169004592 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 454169004593 putative oxidoreductase; Provisional; Region: PRK11579 454169004594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454169004595 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454169004596 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 454169004597 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 454169004598 active site 454169004599 purine riboside binding site [chemical binding]; other site 454169004600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 454169004601 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 454169004602 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 454169004603 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 454169004604 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 454169004605 fumarate hydratase; Provisional; Region: PRK15389 454169004606 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 454169004607 Fumarase C-terminus; Region: Fumerase_C; pfam05683 454169004608 fumarate hydratase; Reviewed; Region: fumC; PRK00485 454169004609 Class II fumarases; Region: Fumarase_classII; cd01362 454169004610 active site 454169004611 tetramer interface [polypeptide binding]; other site 454169004612 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 454169004613 sensor protein RstB; Provisional; Region: PRK10604 454169004614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169004615 dimerization interface [polypeptide binding]; other site 454169004616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169004617 dimer interface [polypeptide binding]; other site 454169004618 phosphorylation site [posttranslational modification] 454169004619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169004620 ATP binding site [chemical binding]; other site 454169004621 Mg2+ binding site [ion binding]; other site 454169004622 G-X-G motif; other site 454169004623 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 454169004624 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 454169004625 active site 454169004626 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169004627 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169004628 trimer interface [polypeptide binding]; other site 454169004629 eyelet of channel; other site 454169004630 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 454169004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169004632 active site 454169004633 phosphorylation site [posttranslational modification] 454169004634 intermolecular recognition site; other site 454169004635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169004636 DNA binding site [nucleotide binding] 454169004637 GlpM protein; Region: GlpM; pfam06942 454169004638 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 454169004639 Spore germination protein; Region: Spore_permease; cl17796 454169004640 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169004641 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169004642 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169004643 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 454169004644 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 454169004645 ligand binding site [chemical binding]; other site 454169004646 homodimer interface [polypeptide binding]; other site 454169004647 NAD(P) binding site [chemical binding]; other site 454169004648 trimer interface B [polypeptide binding]; other site 454169004649 trimer interface A [polypeptide binding]; other site 454169004650 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 454169004651 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 454169004652 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 454169004653 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 454169004654 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454169004655 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 454169004656 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 454169004657 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 454169004658 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454169004659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004660 putative substrate translocation pore; other site 454169004661 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 454169004662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169004663 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 454169004664 dimerization interface [polypeptide binding]; other site 454169004665 substrate binding pocket [chemical binding]; other site 454169004666 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 454169004667 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 454169004668 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169004669 putative dithiobiotin synthetase; Provisional; Region: PRK12374 454169004670 AAA domain; Region: AAA_26; pfam13500 454169004671 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 454169004672 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 454169004673 Cl- selectivity filter; other site 454169004674 Cl- binding residues [ion binding]; other site 454169004675 pore gating glutamate residue; other site 454169004676 dimer interface [polypeptide binding]; other site 454169004677 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 454169004678 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 454169004679 Walker A/P-loop; other site 454169004680 ATP binding site [chemical binding]; other site 454169004681 Q-loop/lid; other site 454169004682 ABC transporter signature motif; other site 454169004683 Walker B; other site 454169004684 D-loop; other site 454169004685 H-loop/switch region; other site 454169004686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 454169004687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169004688 dimer interface [polypeptide binding]; other site 454169004689 conserved gate region; other site 454169004690 ABC-ATPase subunit interface; other site 454169004691 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 454169004692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169004693 dimer interface [polypeptide binding]; other site 454169004694 conserved gate region; other site 454169004695 putative PBP binding loops; other site 454169004696 ABC-ATPase subunit interface; other site 454169004697 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 454169004698 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454169004699 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454169004700 4Fe-4S binding domain; Region: Fer4; pfam00037 454169004701 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454169004702 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454169004703 putative [Fe4-S4] binding site [ion binding]; other site 454169004704 putative molybdopterin cofactor binding site [chemical binding]; other site 454169004705 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454169004706 putative molybdopterin cofactor binding site; other site 454169004707 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454169004708 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454169004709 putative [Fe4-S4] binding site [ion binding]; other site 454169004710 putative molybdopterin cofactor binding site [chemical binding]; other site 454169004711 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454169004712 putative molybdopterin cofactor binding site; other site 454169004713 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 454169004714 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 454169004715 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 454169004716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169004717 Coenzyme A binding pocket [chemical binding]; other site 454169004718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 454169004719 hypothetical protein; Provisional; Region: PRK13659 454169004720 hypothetical protein; Provisional; Region: PRK02237 454169004721 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 454169004722 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 454169004723 putative active site pocket [active] 454169004724 putative metal binding site [ion binding]; other site 454169004725 putative oxidoreductase; Provisional; Region: PRK10083 454169004726 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 454169004727 putative NAD(P) binding site [chemical binding]; other site 454169004728 catalytic Zn binding site [ion binding]; other site 454169004729 structural Zn binding site [ion binding]; other site 454169004730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004731 metabolite-proton symporter; Region: 2A0106; TIGR00883 454169004732 putative substrate translocation pore; other site 454169004733 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 454169004734 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454169004735 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454169004736 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 454169004737 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454169004738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169004739 DNA-binding site [nucleotide binding]; DNA binding site 454169004740 FCD domain; Region: FCD; pfam07729 454169004741 malonic semialdehyde reductase; Provisional; Region: PRK10538 454169004742 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 454169004743 putative NAD(P) binding site [chemical binding]; other site 454169004744 homodimer interface [polypeptide binding]; other site 454169004745 homotetramer interface [polypeptide binding]; other site 454169004746 active site 454169004747 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 454169004748 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 454169004749 active site 454169004750 Zn binding site [ion binding]; other site 454169004751 General stress protein [General function prediction only]; Region: GsiB; COG3729 454169004752 hypothetical protein; Validated; Region: PRK03657 454169004753 hypothetical protein; Provisional; Region: PRK10053 454169004754 putative transporter; Provisional; Region: PRK10054 454169004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004756 putative substrate translocation pore; other site 454169004757 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 454169004758 EamA-like transporter family; Region: EamA; pfam00892 454169004759 MarB protein; Region: MarB; pfam13999 454169004760 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 454169004761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169004762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169004763 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 454169004764 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454169004765 inner membrane protein; Provisional; Region: PRK10995 454169004766 putative arabinose transporter; Provisional; Region: PRK03545 454169004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004768 putative substrate translocation pore; other site 454169004769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169004770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169004771 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 454169004772 putative dimerization interface [polypeptide binding]; other site 454169004773 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 454169004774 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 454169004775 NAD(P) binding site [chemical binding]; other site 454169004776 catalytic residues [active] 454169004777 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 454169004778 glutaminase; Provisional; Region: PRK00971 454169004779 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 454169004780 Predicted membrane protein [Function unknown]; Region: COG3781 454169004781 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 454169004782 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169004783 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169004784 trimer interface [polypeptide binding]; other site 454169004785 eyelet of channel; other site 454169004786 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 454169004787 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 454169004788 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 454169004789 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454169004790 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454169004791 Rubredoxin [Energy production and conversion]; Region: COG1773 454169004792 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 454169004793 iron binding site [ion binding]; other site 454169004794 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 454169004795 HupF/HypC family; Region: HupF_HypC; cl00394 454169004796 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 454169004797 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 454169004798 putative substrate-binding site; other site 454169004799 nickel binding site [ion binding]; other site 454169004800 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 454169004801 hydrogenase 1 large subunit; Provisional; Region: PRK10170 454169004802 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 454169004803 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 454169004804 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 454169004805 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 454169004806 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 454169004807 active site 454169004808 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454169004809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169004810 DNA-binding site [nucleotide binding]; DNA binding site 454169004811 FCD domain; Region: FCD; pfam07729 454169004812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454169004813 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 454169004814 putative NAD(P) binding site [chemical binding]; other site 454169004815 catalytic Zn binding site [ion binding]; other site 454169004816 structural Zn binding site [ion binding]; other site 454169004817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004818 D-galactonate transporter; Region: 2A0114; TIGR00893 454169004819 putative substrate translocation pore; other site 454169004820 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 454169004821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 454169004822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169004824 putative substrate translocation pore; other site 454169004825 hypothetical protein; Provisional; Region: PRK06184 454169004826 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454169004827 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454169004828 Transcriptional regulators [Transcription]; Region: MarR; COG1846 454169004829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169004830 putative DNA binding site [nucleotide binding]; other site 454169004831 putative Zn2+ binding site [ion binding]; other site 454169004832 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 454169004833 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 454169004834 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 454169004835 homotrimer interaction site [polypeptide binding]; other site 454169004836 putative active site [active] 454169004837 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 454169004838 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 454169004839 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 454169004840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169004841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169004842 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 454169004843 putative effector binding pocket; other site 454169004844 putative dimerization interface [polypeptide binding]; other site 454169004845 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 454169004846 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 454169004847 FMN binding site [chemical binding]; other site 454169004848 substrate binding site [chemical binding]; other site 454169004849 putative catalytic residue [active] 454169004850 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454169004851 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169004852 DNA binding site [nucleotide binding] 454169004853 domain linker motif; other site 454169004854 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454169004855 dimerization interface (closed form) [polypeptide binding]; other site 454169004856 ligand binding site [chemical binding]; other site 454169004857 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 454169004858 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 454169004859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169004860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169004861 homodimer interface [polypeptide binding]; other site 454169004862 catalytic residue [active] 454169004863 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 454169004864 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 454169004865 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 454169004866 active site 454169004867 catalytic site [active] 454169004868 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 454169004869 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 454169004870 active site 454169004871 catalytic site [active] 454169004872 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 454169004873 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 454169004874 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 454169004875 catalytic site [active] 454169004876 active site 454169004877 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 454169004878 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 454169004879 acid-resistance protein; Provisional; Region: hdeB; PRK11566 454169004880 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 454169004881 biofilm-dependent modulation protein; Provisional; Region: PRK11436 454169004882 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 454169004883 malate dehydrogenase; Provisional; Region: PRK13529 454169004884 Malic enzyme, N-terminal domain; Region: malic; pfam00390 454169004885 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 454169004886 NAD(P) binding site [chemical binding]; other site 454169004887 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 454169004888 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 454169004889 NAD binding site [chemical binding]; other site 454169004890 substrate binding site [chemical binding]; other site 454169004891 catalytic Zn binding site [ion binding]; other site 454169004892 tetramer interface [polypeptide binding]; other site 454169004893 structural Zn binding site [ion binding]; other site 454169004894 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 454169004895 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 454169004896 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 454169004897 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 454169004898 aromatic amino acid exporter; Provisional; Region: PRK11689 454169004899 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169004900 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169004901 trimer interface [polypeptide binding]; other site 454169004902 eyelet of channel; other site 454169004903 Uncharacterized conserved protein [Function unknown]; Region: COG3791 454169004904 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 454169004905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169004906 putative substrate translocation pore; other site 454169004907 TetR family transcriptional regulator; Provisional; Region: PRK14996 454169004908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169004909 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 454169004910 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 454169004911 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 454169004912 [4Fe-4S] binding site [ion binding]; other site 454169004913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169004914 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169004915 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169004916 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 454169004917 molybdopterin cofactor binding site; other site 454169004918 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 454169004919 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 454169004920 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 454169004921 hypothetical protein; Provisional; Region: PRK10281 454169004922 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 454169004923 L-asparagine permease; Provisional; Region: PRK15049 454169004924 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454169004925 Uncharacterized conserved protein [Function unknown]; Region: COG3391 454169004926 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 454169004927 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 454169004928 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169004929 N-terminal plug; other site 454169004930 ligand-binding site [chemical binding]; other site 454169004931 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 454169004932 DNA-binding site [nucleotide binding]; DNA binding site 454169004933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 454169004934 FCD domain; Region: FCD; pfam07729 454169004935 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 454169004936 Prostaglandin dehydrogenases; Region: PGDH; cd05288 454169004937 NAD(P) binding site [chemical binding]; other site 454169004938 substrate binding site [chemical binding]; other site 454169004939 dimer interface [polypeptide binding]; other site 454169004940 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 454169004941 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 454169004942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 454169004943 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 454169004944 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 454169004945 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 454169004946 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 454169004947 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 454169004948 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 454169004949 tetrameric interface [polypeptide binding]; other site 454169004950 NAD binding site [chemical binding]; other site 454169004951 catalytic residues [active] 454169004952 substrate binding site [chemical binding]; other site 454169004953 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 454169004954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169004955 DNA-binding site [nucleotide binding]; DNA binding site 454169004956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169004957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169004958 homodimer interface [polypeptide binding]; other site 454169004959 catalytic residue [active] 454169004960 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 454169004961 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 454169004962 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 454169004963 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 454169004964 Peptidase family U32; Region: Peptidase_U32; pfam01136 454169004965 Collagenase; Region: DUF3656; pfam12392 454169004966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 454169004967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169004968 non-specific DNA binding site [nucleotide binding]; other site 454169004969 salt bridge; other site 454169004970 sequence-specific DNA binding site [nucleotide binding]; other site 454169004971 Cupin domain; Region: Cupin_2; pfam07883 454169004972 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 454169004973 benzoate transporter; Region: benE; TIGR00843 454169004974 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 454169004975 tellurite resistance protein TehB; Provisional; Region: PRK11207 454169004976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169004977 S-adenosylmethionine binding site [chemical binding]; other site 454169004978 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 454169004979 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 454169004980 gating phenylalanine in ion channel; other site 454169004981 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 454169004982 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 454169004983 putative trimer interface [polypeptide binding]; other site 454169004984 putative CoA binding site [chemical binding]; other site 454169004985 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 454169004986 putative trimer interface [polypeptide binding]; other site 454169004987 putative CoA binding site [chemical binding]; other site 454169004988 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 454169004989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169004990 Coenzyme A binding pocket [chemical binding]; other site 454169004991 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 454169004992 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 454169004993 oligomer interface [polypeptide binding]; other site 454169004994 active site 454169004995 metal binding site [ion binding]; metal-binding site 454169004996 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454169004997 active site 454169004998 P-loop; other site 454169004999 phosphorylation site [posttranslational modification] 454169005000 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454169005001 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 454169005002 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 454169005003 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169005004 active site 454169005005 phosphorylation site [posttranslational modification] 454169005006 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 454169005007 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454169005008 substrate binding site [chemical binding]; other site 454169005009 hexamer interface [polypeptide binding]; other site 454169005010 metal binding site [ion binding]; metal-binding site 454169005011 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169005012 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454169005013 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169005014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169005015 Coenzyme A binding pocket [chemical binding]; other site 454169005016 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 454169005017 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 454169005018 teramer interface [polypeptide binding]; other site 454169005019 active site 454169005020 FMN binding site [chemical binding]; other site 454169005021 catalytic residues [active] 454169005022 Uncharacterized conserved protein [Function unknown]; Region: COG2353 454169005023 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 454169005024 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 454169005025 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 454169005026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 454169005027 substrate binding pocket [chemical binding]; other site 454169005028 catalytic triad [active] 454169005029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 454169005030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 454169005031 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 454169005032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169005033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169005034 dimerization interface [polypeptide binding]; other site 454169005035 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454169005036 dimer interface [polypeptide binding]; other site 454169005037 ligand binding site [chemical binding]; other site 454169005038 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 454169005039 HAMP domain; Region: HAMP; pfam00672 454169005040 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169005041 dimer interface [polypeptide binding]; other site 454169005042 putative CheW interface [polypeptide binding]; other site 454169005043 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 454169005044 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 454169005045 substrate binding site [chemical binding]; other site 454169005046 catalytic Zn binding site [ion binding]; other site 454169005047 NAD binding site [chemical binding]; other site 454169005048 structural Zn binding site [ion binding]; other site 454169005049 dimer interface [polypeptide binding]; other site 454169005050 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 454169005051 putative metal binding site [ion binding]; other site 454169005052 putative homodimer interface [polypeptide binding]; other site 454169005053 putative homotetramer interface [polypeptide binding]; other site 454169005054 putative homodimer-homodimer interface [polypeptide binding]; other site 454169005055 putative allosteric switch controlling residues; other site 454169005056 Sif protein; Region: Sif; cl11505 454169005057 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 454169005058 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 454169005059 active site 454169005060 catalytic triad [active] 454169005061 oxyanion hole [active] 454169005062 Predicted membrane protein [Function unknown]; Region: COG3326 454169005063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169005064 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 454169005065 substrate binding pocket [chemical binding]; other site 454169005066 membrane-bound complex binding site; other site 454169005067 hinge residues; other site 454169005068 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169005069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169005070 dimer interface [polypeptide binding]; other site 454169005071 conserved gate region; other site 454169005072 putative PBP binding loops; other site 454169005073 ABC-ATPase subunit interface; other site 454169005074 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 454169005075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169005076 Walker A/P-loop; other site 454169005077 ATP binding site [chemical binding]; other site 454169005078 Q-loop/lid; other site 454169005079 ABC transporter signature motif; other site 454169005080 Walker B; other site 454169005081 D-loop; other site 454169005082 H-loop/switch region; other site 454169005083 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169005084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169005085 dimer interface [polypeptide binding]; other site 454169005086 conserved gate region; other site 454169005087 putative PBP binding loops; other site 454169005088 ABC-ATPase subunit interface; other site 454169005089 Predicted membrane protein [Function unknown]; Region: COG5305 454169005090 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 454169005091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169005092 S-adenosylmethionine binding site [chemical binding]; other site 454169005093 cytochrome b561; Provisional; Region: PRK11513 454169005094 Uncharacterized conserved protein [Function unknown]; Region: COG1434 454169005095 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454169005096 putative active site [active] 454169005097 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 454169005098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169005099 ATP binding site [chemical binding]; other site 454169005100 putative Mg++ binding site [ion binding]; other site 454169005101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169005102 nucleotide binding region [chemical binding]; other site 454169005103 ATP-binding site [chemical binding]; other site 454169005104 Helicase associated domain (HA2); Region: HA2; pfam04408 454169005105 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 454169005106 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 454169005107 azoreductase; Reviewed; Region: PRK00170 454169005108 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 454169005109 Uncharacterized conserved protein [Function unknown]; Region: COG3791 454169005110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 454169005111 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 454169005112 hypothetical protein; Provisional; Region: PRK10695 454169005113 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 454169005114 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 454169005115 putative ligand binding site [chemical binding]; other site 454169005116 putative NAD binding site [chemical binding]; other site 454169005117 catalytic site [active] 454169005118 heat-inducible protein; Provisional; Region: PRK10449 454169005119 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 454169005120 Domain of unknown function (DUF333); Region: DUF333; pfam03891 454169005121 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 454169005122 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 454169005123 dimer interface [polypeptide binding]; other site 454169005124 PYR/PP interface [polypeptide binding]; other site 454169005125 TPP binding site [chemical binding]; other site 454169005126 substrate binding site [chemical binding]; other site 454169005127 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 454169005128 Domain of unknown function; Region: EKR; smart00890 454169005129 4Fe-4S binding domain; Region: Fer4_6; pfam12837 454169005130 4Fe-4S binding domain; Region: Fer4; pfam00037 454169005131 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 454169005132 TPP-binding site [chemical binding]; other site 454169005133 dimer interface [polypeptide binding]; other site 454169005134 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454169005135 Ligand Binding Site [chemical binding]; other site 454169005136 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 454169005137 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 454169005138 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 454169005139 Ligand Binding Site [chemical binding]; other site 454169005140 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 454169005141 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454169005142 ATP binding site [chemical binding]; other site 454169005143 Mg++ binding site [ion binding]; other site 454169005144 motif III; other site 454169005145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169005146 nucleotide binding region [chemical binding]; other site 454169005147 ATP-binding site [chemical binding]; other site 454169005148 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 454169005149 putative RNA binding site [nucleotide binding]; other site 454169005150 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 454169005151 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 454169005152 Cl binding site [ion binding]; other site 454169005153 oligomer interface [polypeptide binding]; other site 454169005154 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 454169005155 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169005156 dimer interface [polypeptide binding]; other site 454169005157 putative CheW interface [polypeptide binding]; other site 454169005158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 454169005159 Smr domain; Region: Smr; pfam01713 454169005160 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 454169005161 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 454169005162 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 454169005163 DNA binding site [nucleotide binding] 454169005164 active site 454169005165 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 454169005166 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 454169005167 ligand binding site [chemical binding]; other site 454169005168 flexible hinge region; other site 454169005169 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 454169005170 putative switch regulator; other site 454169005171 non-specific DNA interactions [nucleotide binding]; other site 454169005172 DNA binding site [nucleotide binding] 454169005173 sequence specific DNA binding site [nucleotide binding]; other site 454169005174 putative cAMP binding site [chemical binding]; other site 454169005175 universal stress protein UspE; Provisional; Region: PRK11175 454169005176 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454169005177 Ligand Binding Site [chemical binding]; other site 454169005178 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454169005179 Ligand Binding Site [chemical binding]; other site 454169005180 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 454169005181 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 454169005182 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169005183 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 454169005184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169005185 non-specific DNA binding site [nucleotide binding]; other site 454169005186 salt bridge; other site 454169005187 sequence-specific DNA binding site [nucleotide binding]; other site 454169005188 Cupin domain; Region: Cupin_2; pfam07883 454169005189 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 454169005190 B3/4 domain; Region: B3_4; pfam03483 454169005191 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 454169005192 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 454169005193 Transposase domain (DUF772); Region: DUF772; pfam05598 454169005194 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169005195 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169005196 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454169005197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454169005198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169005199 oxidoreductase; Provisional; Region: PRK12742 454169005200 classical (c) SDRs; Region: SDR_c; cd05233 454169005201 NAD(P) binding site [chemical binding]; other site 454169005202 active site 454169005203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169005204 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169005205 active site 454169005206 catalytic tetrad [active] 454169005207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169005208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169005209 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 454169005210 putative effector binding pocket; other site 454169005211 putative dimerization interface [polypeptide binding]; other site 454169005212 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 454169005213 NmrA-like family; Region: NmrA; pfam05368 454169005214 NAD(P) binding site [chemical binding]; other site 454169005215 active site lysine 454169005216 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 454169005217 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 454169005218 peptide binding site [polypeptide binding]; other site 454169005219 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 454169005220 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 454169005221 putative active site [active] 454169005222 Zn binding site [ion binding]; other site 454169005223 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 454169005224 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 454169005225 active site 454169005226 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 454169005227 dimer interface [polypeptide binding]; other site 454169005228 catalytic triad [active] 454169005229 peroxidatic and resolving cysteines [active] 454169005230 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 454169005231 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 454169005232 putative aromatic amino acid binding site; other site 454169005233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169005234 Walker A motif; other site 454169005235 ATP binding site [chemical binding]; other site 454169005236 Walker B motif; other site 454169005237 arginine finger; other site 454169005238 hypothetical protein; Provisional; Region: PRK05415 454169005239 TIGR01620 family protein; Region: hyp_HI0043 454169005240 Predicted ATPase [General function prediction only]; Region: COG3106 454169005241 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 454169005242 active site residue [active] 454169005243 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 454169005244 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 454169005245 phage shock protein C; Region: phageshock_pspC; TIGR02978 454169005246 phage shock protein B; Provisional; Region: pspB; PRK09458 454169005247 phage shock protein PspA; Provisional; Region: PRK10698 454169005248 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 454169005249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169005250 Walker A motif; other site 454169005251 ATP binding site [chemical binding]; other site 454169005252 Walker B motif; other site 454169005253 arginine finger; other site 454169005254 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 454169005255 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 454169005256 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 454169005257 peptide binding site [polypeptide binding]; other site 454169005258 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 454169005259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169005260 dimer interface [polypeptide binding]; other site 454169005261 conserved gate region; other site 454169005262 putative PBP binding loops; other site 454169005263 ABC-ATPase subunit interface; other site 454169005264 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 454169005265 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454169005266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169005267 dimer interface [polypeptide binding]; other site 454169005268 conserved gate region; other site 454169005269 putative PBP binding loops; other site 454169005270 ABC-ATPase subunit interface; other site 454169005271 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 454169005272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169005273 Walker A/P-loop; other site 454169005274 ATP binding site [chemical binding]; other site 454169005275 Q-loop/lid; other site 454169005276 ABC transporter signature motif; other site 454169005277 Walker B; other site 454169005278 D-loop; other site 454169005279 H-loop/switch region; other site 454169005280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454169005281 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 454169005282 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169005283 Walker A/P-loop; other site 454169005284 ATP binding site [chemical binding]; other site 454169005285 Q-loop/lid; other site 454169005286 ABC transporter signature motif; other site 454169005287 Walker B; other site 454169005288 D-loop; other site 454169005289 H-loop/switch region; other site 454169005290 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 454169005291 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 454169005292 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 454169005293 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 454169005294 NAD binding site [chemical binding]; other site 454169005295 homotetramer interface [polypeptide binding]; other site 454169005296 homodimer interface [polypeptide binding]; other site 454169005297 substrate binding site [chemical binding]; other site 454169005298 active site 454169005299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 454169005300 Uncharacterized conserved protein [Function unknown]; Region: COG2128 454169005301 exoribonuclease II; Provisional; Region: PRK05054 454169005302 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 454169005303 RNB domain; Region: RNB; pfam00773 454169005304 S1 RNA binding domain; Region: S1; pfam00575 454169005305 RNase II stability modulator; Provisional; Region: PRK10060 454169005306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169005307 putative active site [active] 454169005308 heme pocket [chemical binding]; other site 454169005309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169005310 metal binding site [ion binding]; metal-binding site 454169005311 active site 454169005312 I-site; other site 454169005313 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169005314 hypothetical protein; Provisional; Region: PRK13658 454169005315 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169005316 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169005317 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169005318 lipoprotein; Provisional; Region: PRK10540 454169005319 translation initiation factor Sui1; Validated; Region: PRK06824 454169005320 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 454169005321 putative rRNA binding site [nucleotide binding]; other site 454169005322 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 454169005323 active site 454169005324 dimer interface [polypeptide binding]; other site 454169005325 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 454169005326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 454169005327 TPR motif; other site 454169005328 binding surface 454169005329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454169005330 binding surface 454169005331 TPR motif; other site 454169005332 Predicted membrane protein [Function unknown]; Region: COG3771 454169005333 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454169005334 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 454169005335 active site 454169005336 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 454169005337 dimerization interface [polypeptide binding]; other site 454169005338 active site 454169005339 aconitate hydratase; Validated; Region: PRK09277 454169005340 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 454169005341 substrate binding site [chemical binding]; other site 454169005342 ligand binding site [chemical binding]; other site 454169005343 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 454169005344 substrate binding site [chemical binding]; other site 454169005345 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 454169005346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169005347 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 454169005348 substrate binding site [chemical binding]; other site 454169005349 putative dimerization interface [polypeptide binding]; other site 454169005350 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 454169005351 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 454169005352 active site 454169005353 interdomain interaction site; other site 454169005354 putative metal-binding site [ion binding]; other site 454169005355 nucleotide binding site [chemical binding]; other site 454169005356 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 454169005357 domain I; other site 454169005358 DNA binding groove [nucleotide binding] 454169005359 phosphate binding site [ion binding]; other site 454169005360 domain II; other site 454169005361 domain III; other site 454169005362 nucleotide binding site [chemical binding]; other site 454169005363 catalytic site [active] 454169005364 domain IV; other site 454169005365 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454169005366 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454169005367 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 454169005368 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 454169005369 hypothetical protein; Provisional; Region: PRK11037 454169005370 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 454169005371 putative inner membrane peptidase; Provisional; Region: PRK11778 454169005372 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 454169005373 tandem repeat interface [polypeptide binding]; other site 454169005374 oligomer interface [polypeptide binding]; other site 454169005375 active site residues [active] 454169005376 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 454169005377 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 454169005378 NADP binding site [chemical binding]; other site 454169005379 homodimer interface [polypeptide binding]; other site 454169005380 active site 454169005381 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 454169005382 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 454169005383 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 454169005384 homodimer interface [polypeptide binding]; other site 454169005385 Walker A motif; other site 454169005386 ATP binding site [chemical binding]; other site 454169005387 hydroxycobalamin binding site [chemical binding]; other site 454169005388 Walker B motif; other site 454169005389 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 454169005390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169005391 RNA binding surface [nucleotide binding]; other site 454169005392 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 454169005393 probable active site [active] 454169005394 hypothetical protein; Provisional; Region: PRK11630 454169005395 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 454169005396 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 454169005397 active site 454169005398 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 454169005399 Tryptophan operon leader 454169005400 anthranilate synthase component I; Provisional; Region: PRK13564 454169005401 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 454169005402 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 454169005403 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 454169005404 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 454169005405 glutamine binding [chemical binding]; other site 454169005406 catalytic triad [active] 454169005407 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 454169005408 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 454169005409 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 454169005410 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 454169005411 active site 454169005412 ribulose/triose binding site [chemical binding]; other site 454169005413 phosphate binding site [ion binding]; other site 454169005414 substrate (anthranilate) binding pocket [chemical binding]; other site 454169005415 product (indole) binding pocket [chemical binding]; other site 454169005416 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 454169005417 active site 454169005418 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 454169005419 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 454169005420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169005421 catalytic residue [active] 454169005422 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 454169005423 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 454169005424 substrate binding site [chemical binding]; other site 454169005425 active site 454169005426 catalytic residues [active] 454169005427 heterodimer interface [polypeptide binding]; other site 454169005428 General stress protein [General function prediction only]; Region: GsiB; COG3729 454169005429 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 454169005430 dimerization interface [polypeptide binding]; other site 454169005431 metal binding site [ion binding]; metal-binding site 454169005432 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 454169005433 dinuclear metal binding motif [ion binding]; other site 454169005434 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 454169005435 dimanganese center [ion binding]; other site 454169005436 outer membrane protein W; Provisional; Region: PRK10959 454169005437 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 454169005438 hypothetical protein; Provisional; Region: PRK02868 454169005439 intracellular septation protein A; Reviewed; Region: PRK00259 454169005440 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 454169005441 transport protein TonB; Provisional; Region: PRK10819 454169005442 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 454169005443 YciI-like protein; Reviewed; Region: PRK11370 454169005444 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 454169005445 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 454169005446 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 454169005447 putative active site [active] 454169005448 catalytic site [active] 454169005449 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 454169005450 putative active site [active] 454169005451 catalytic site [active] 454169005452 Ion transport protein; Region: Ion_trans; pfam00520 454169005453 Ion channel; Region: Ion_trans_2; pfam07885 454169005454 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 454169005455 Double zinc ribbon; Region: DZR; pfam12773 454169005456 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 454169005457 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169005458 Walker A/P-loop; other site 454169005459 ATP binding site [chemical binding]; other site 454169005460 Q-loop/lid; other site 454169005461 ABC transporter signature motif; other site 454169005462 Walker B; other site 454169005463 D-loop; other site 454169005464 H-loop/switch region; other site 454169005465 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 454169005466 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 454169005467 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169005468 Walker A/P-loop; other site 454169005469 ATP binding site [chemical binding]; other site 454169005470 Q-loop/lid; other site 454169005471 ABC transporter signature motif; other site 454169005472 Walker B; other site 454169005473 D-loop; other site 454169005474 H-loop/switch region; other site 454169005475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454169005476 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 454169005477 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454169005478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169005479 dimer interface [polypeptide binding]; other site 454169005480 conserved gate region; other site 454169005481 ABC-ATPase subunit interface; other site 454169005482 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 454169005483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169005484 dimer interface [polypeptide binding]; other site 454169005485 conserved gate region; other site 454169005486 putative PBP binding loops; other site 454169005487 ABC-ATPase subunit interface; other site 454169005488 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 454169005489 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 454169005490 peptide binding site [polypeptide binding]; other site 454169005491 hypothetical protein; Provisional; Region: PRK11111 454169005492 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 454169005493 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 454169005494 putative catalytic cysteine [active] 454169005495 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 454169005496 putative active site [active] 454169005497 metal binding site [ion binding]; metal-binding site 454169005498 thymidine kinase; Provisional; Region: PRK04296 454169005499 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 454169005500 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 454169005501 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 454169005502 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 454169005503 active site 454169005504 tetramer interface; other site 454169005505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169005506 active site 454169005507 response regulator of RpoS; Provisional; Region: PRK10693 454169005508 phosphorylation site [posttranslational modification] 454169005509 intermolecular recognition site; other site 454169005510 dimerization interface [polypeptide binding]; other site 454169005511 hypothetical protein; Provisional; Region: PRK10279 454169005512 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 454169005513 active site 454169005514 nucleophile elbow; other site 454169005515 SEC-C motif; Region: SEC-C; pfam02810 454169005516 hypothetical protein; Provisional; Region: PRK04233 454169005517 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 454169005518 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 454169005519 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 454169005520 putative active site [active] 454169005521 putative substrate binding site [chemical binding]; other site 454169005522 putative cosubstrate binding site; other site 454169005523 catalytic site [active] 454169005524 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169005525 Sel1-like repeats; Region: SEL1; smart00671 454169005526 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169005527 Sel1-like repeats; Region: SEL1; smart00671 454169005528 Sel1-like repeats; Region: SEL1; smart00671 454169005529 Sel1-like repeats; Region: SEL1; smart00671 454169005530 Sel1-like repeats; Region: SEL1; smart00671 454169005531 Sel1-like repeats; Region: SEL1; smart00671 454169005532 Sel1-like repeats; Region: SEL1; smart00671 454169005533 Sel1-like repeats; Region: SEL1; smart00671 454169005534 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 454169005535 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 454169005536 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 454169005537 4Fe-4S binding domain; Region: Fer4; cl02805 454169005538 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 454169005539 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 454169005540 [4Fe-4S] binding site [ion binding]; other site 454169005541 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169005542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169005543 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169005544 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 454169005545 molybdopterin cofactor binding site; other site 454169005546 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 454169005547 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 454169005548 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 454169005549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169005550 dimerization interface [polypeptide binding]; other site 454169005551 Histidine kinase; Region: HisKA_3; pfam07730 454169005552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169005553 ATP binding site [chemical binding]; other site 454169005554 Mg2+ binding site [ion binding]; other site 454169005555 G-X-G motif; other site 454169005556 transcriptional regulator NarL; Provisional; Region: PRK10651 454169005557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169005558 active site 454169005559 phosphorylation site [posttranslational modification] 454169005560 intermolecular recognition site; other site 454169005561 dimerization interface [polypeptide binding]; other site 454169005562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169005563 DNA binding residues [nucleotide binding] 454169005564 dimerization interface [polypeptide binding]; other site 454169005565 putative invasin; Provisional; Region: PRK10177 454169005566 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 454169005567 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 454169005568 cation transport regulator; Reviewed; Region: chaB; PRK09582 454169005569 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 454169005570 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 454169005571 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 454169005572 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454169005573 hypothetical protein; Provisional; Region: PRK10941 454169005574 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 454169005575 hypothetical protein; Provisional; Region: PRK10278 454169005576 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 454169005577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169005578 peptide chain release factor 1; Validated; Region: prfA; PRK00591 454169005579 This domain is found in peptide chain release factors; Region: PCRF; smart00937 454169005580 RF-1 domain; Region: RF-1; pfam00472 454169005581 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 454169005582 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 454169005583 tRNA; other site 454169005584 putative tRNA binding site [nucleotide binding]; other site 454169005585 putative NADP binding site [chemical binding]; other site 454169005586 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 454169005587 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 454169005588 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 454169005589 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 454169005590 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 454169005591 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 454169005592 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 454169005593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169005594 active site 454169005595 putative transporter; Provisional; Region: PRK11660 454169005596 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 454169005597 Sulfate transporter family; Region: Sulfate_transp; pfam00916 454169005598 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 454169005599 hypothetical protein; Provisional; Region: PRK10692 454169005600 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 454169005601 putative active site [active] 454169005602 catalytic residue [active] 454169005603 GTP-binding protein YchF; Reviewed; Region: PRK09601 454169005604 YchF GTPase; Region: YchF; cd01900 454169005605 G1 box; other site 454169005606 GTP/Mg2+ binding site [chemical binding]; other site 454169005607 Switch I region; other site 454169005608 G2 box; other site 454169005609 Switch II region; other site 454169005610 G3 box; other site 454169005611 G4 box; other site 454169005612 G5 box; other site 454169005613 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 454169005614 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 454169005615 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 454169005616 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 454169005617 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 454169005618 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 454169005619 hydrogenase 1 large subunit; Provisional; Region: PRK10170 454169005620 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 454169005621 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 454169005622 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 454169005623 putative substrate-binding site; other site 454169005624 nickel binding site [ion binding]; other site 454169005625 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 454169005626 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454169005627 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454169005628 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 454169005629 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 454169005630 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 454169005631 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 454169005632 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 454169005633 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 454169005634 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 454169005635 NAD(P) binding site [chemical binding]; other site 454169005636 trehalase; Provisional; Region: treA; PRK13271 454169005637 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 454169005638 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 454169005639 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 454169005640 Flagellar regulator YcgR; Region: YcgR; pfam07317 454169005641 PilZ domain; Region: PilZ; pfam07238 454169005642 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 454169005643 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169005644 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169005645 catalytic residue [active] 454169005646 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 454169005647 dimer interface [polypeptide binding]; other site 454169005648 catalytic triad [active] 454169005649 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 454169005650 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 454169005651 TrkA-C domain; Region: TrkA_C; pfam02080 454169005652 Transporter associated domain; Region: CorC_HlyC; smart01091 454169005653 alanine racemase; Reviewed; Region: dadX; PRK03646 454169005654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 454169005655 active site 454169005656 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169005657 substrate binding site [chemical binding]; other site 454169005658 catalytic residues [active] 454169005659 dimer interface [polypeptide binding]; other site 454169005660 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 454169005661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454169005662 SpoVR family protein; Provisional; Region: PRK11767 454169005663 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 454169005664 fatty acid metabolism regulator; Provisional; Region: PRK04984 454169005665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169005666 DNA-binding site [nucleotide binding]; DNA binding site 454169005667 FadR C-terminal domain; Region: FadR_C; pfam07840 454169005668 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 454169005669 transmembrane helices; other site 454169005670 disulfide bond formation protein B; Provisional; Region: PRK01749 454169005671 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 454169005672 GnsA/GnsB family; Region: GnsAB; pfam08178 454169005673 hypothetical protein; Provisional; Region: PRK05170 454169005674 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 454169005675 hypothetical protein; Provisional; Region: PRK10691 454169005676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 454169005677 septum formation inhibitor; Reviewed; Region: minC; PRK03511 454169005678 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 454169005679 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 454169005680 cell division inhibitor MinD; Provisional; Region: PRK10818 454169005681 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 454169005682 Switch I; other site 454169005683 Switch II; other site 454169005684 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 454169005685 ribonuclease D; Provisional; Region: PRK10829 454169005686 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 454169005687 catalytic site [active] 454169005688 putative active site [active] 454169005689 putative substrate binding site [chemical binding]; other site 454169005690 HRDC domain; Region: HRDC; cl02578 454169005691 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 454169005692 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 454169005693 acyl-activating enzyme (AAE) consensus motif; other site 454169005694 putative AMP binding site [chemical binding]; other site 454169005695 putative active site [active] 454169005696 putative CoA binding site [chemical binding]; other site 454169005697 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 454169005698 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 454169005699 Glycoprotease family; Region: Peptidase_M22; pfam00814 454169005700 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 454169005701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 454169005702 DEAD_2; Region: DEAD_2; pfam06733 454169005703 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 454169005704 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 454169005705 homotrimer interaction site [polypeptide binding]; other site 454169005706 putative active site [active] 454169005707 hypothetical protein; Provisional; Region: PRK05114 454169005708 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 454169005709 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 454169005710 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 454169005711 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 454169005712 putative active site [active] 454169005713 putative CoA binding site [chemical binding]; other site 454169005714 nudix motif; other site 454169005715 metal binding site [ion binding]; metal-binding site 454169005716 L-serine deaminase; Provisional; Region: PRK15023 454169005717 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454169005718 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454169005719 phage resistance protein; Provisional; Region: PRK10551 454169005720 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454169005721 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169005722 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 454169005723 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 454169005724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454169005725 Transporter associated domain; Region: CorC_HlyC; smart01091 454169005726 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 454169005727 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454169005728 active pocket/dimerization site; other site 454169005729 active site 454169005730 phosphorylation site [posttranslational modification] 454169005731 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 454169005732 active site 454169005733 phosphorylation site [posttranslational modification] 454169005734 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 454169005735 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 454169005736 hypothetical protein; Provisional; Region: PRK02913 454169005737 yybP-ykoY leader 454169005738 hypothetical protein; Provisional; Region: PRK11469 454169005739 Domain of unknown function DUF; Region: DUF204; pfam02659 454169005740 Domain of unknown function DUF; Region: DUF204; pfam02659 454169005741 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 454169005742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169005743 S-adenosylmethionine binding site [chemical binding]; other site 454169005744 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 454169005745 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454169005746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454169005747 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454169005748 DNA-binding site [nucleotide binding]; DNA binding site 454169005749 RNA-binding motif; other site 454169005750 YebO-like protein; Region: YebO; pfam13974 454169005751 PhoPQ regulatory protein; Provisional; Region: PRK10299 454169005752 YobH-like protein; Region: YobH; pfam13996 454169005753 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 454169005754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169005755 dimerization interface [polypeptide binding]; other site 454169005756 putative Zn2+ binding site [ion binding]; other site 454169005757 putative DNA binding site [nucleotide binding]; other site 454169005758 Bacterial transcriptional regulator; Region: IclR; pfam01614 454169005759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169005760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169005761 putative substrate translocation pore; other site 454169005762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169005763 heat shock protein HtpX; Provisional; Region: PRK05457 454169005764 carboxy-terminal protease; Provisional; Region: PRK11186 454169005765 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 454169005766 protein binding site [polypeptide binding]; other site 454169005767 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 454169005768 Catalytic dyad [active] 454169005769 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 454169005770 ProP expression regulator; Provisional; Region: PRK04950 454169005771 ProQ/FINO family; Region: ProQ; pfam04352 454169005772 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 454169005773 GAF domain; Region: GAF_2; pfam13185 454169005774 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 454169005775 Paraquat-inducible protein A; Region: PqiA; pfam04403 454169005776 Paraquat-inducible protein A; Region: PqiA; pfam04403 454169005777 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 454169005778 mce related protein; Region: MCE; pfam02470 454169005779 mce related protein; Region: MCE; pfam02470 454169005780 mce related protein; Region: MCE; pfam02470 454169005781 mce related protein; Region: MCE; pfam02470 454169005782 mce related protein; Region: MCE; pfam02470 454169005783 mce related protein; Region: MCE; pfam02470 454169005784 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 454169005785 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 454169005786 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 454169005787 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 454169005788 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 454169005789 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 454169005790 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454169005791 type III secretion protein SopE2; Provisional; Region: PRK15280 454169005792 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 454169005793 SopE GEF domain; Region: SopE_GEF; pfam07487 454169005794 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 454169005795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169005796 Coenzyme A binding pocket [chemical binding]; other site 454169005797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454169005798 DNA binding site [nucleotide binding] 454169005799 active site 454169005800 Int/Topo IB signature motif; other site 454169005801 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454169005802 EamA-like transporter family; Region: EamA; pfam00892 454169005803 EamA-like transporter family; Region: EamA; pfam00892 454169005804 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 454169005805 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 454169005806 Transposase domain (DUF772); Region: DUF772; pfam05598 454169005807 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169005808 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169005809 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454169005810 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 454169005811 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 454169005812 exonuclease VIII; Reviewed; Region: PRK09709 454169005813 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 454169005814 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 454169005815 dimer interface [polypeptide binding]; other site 454169005816 active site 454169005817 Int/Topo IB signature motif; other site 454169005818 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 454169005819 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 454169005820 hypothetical protein; Provisional; Region: PRK10301 454169005821 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 454169005822 Predicted amidohydrolase [General function prediction only]; Region: COG0388 454169005823 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 454169005824 exodeoxyribonuclease X; Provisional; Region: PRK07983 454169005825 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 454169005826 active site 454169005827 catalytic site [active] 454169005828 substrate binding site [chemical binding]; other site 454169005829 protease 2; Provisional; Region: PRK10115 454169005830 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454169005831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 454169005832 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 454169005833 putative metal binding site [ion binding]; other site 454169005834 hypothetical protein; Provisional; Region: PRK13680 454169005835 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 454169005836 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 454169005837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454169005838 ATP-grasp domain; Region: ATP-grasp; pfam02222 454169005839 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 454169005840 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 454169005841 active site 454169005842 intersubunit interface [polypeptide binding]; other site 454169005843 catalytic residue [active] 454169005844 phosphogluconate dehydratase; Validated; Region: PRK09054 454169005845 6-phosphogluconate dehydratase; Region: edd; TIGR01196 454169005846 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 454169005847 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 454169005848 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 454169005849 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 454169005850 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 454169005851 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 454169005852 putative active site [active] 454169005853 pyruvate kinase; Provisional; Region: PRK05826 454169005854 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 454169005855 domain interfaces; other site 454169005856 active site 454169005857 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 454169005858 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 454169005859 putative acyl-acceptor binding pocket; other site 454169005860 putative peptidase; Provisional; Region: PRK11649 454169005861 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 454169005862 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169005863 Peptidase family M23; Region: Peptidase_M23; pfam01551 454169005864 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 454169005865 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 454169005866 metal binding site [ion binding]; metal-binding site 454169005867 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 454169005868 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 454169005869 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 454169005870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169005871 ABC-ATPase subunit interface; other site 454169005872 dimer interface [polypeptide binding]; other site 454169005873 putative PBP binding regions; other site 454169005874 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 454169005875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169005876 Walker A motif; other site 454169005877 ATP binding site [chemical binding]; other site 454169005878 Walker B motif; other site 454169005879 arginine finger; other site 454169005880 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 454169005881 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 454169005882 RuvA N terminal domain; Region: RuvA_N; pfam01330 454169005883 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 454169005884 hypothetical protein; Provisional; Region: PRK11470 454169005885 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 454169005886 active site 454169005887 putative DNA-binding cleft [nucleotide binding]; other site 454169005888 dimer interface [polypeptide binding]; other site 454169005889 hypothetical protein; Validated; Region: PRK00110 454169005890 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 454169005891 nudix motif; other site 454169005892 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 454169005893 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 454169005894 dimer interface [polypeptide binding]; other site 454169005895 anticodon binding site; other site 454169005896 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 454169005897 homodimer interface [polypeptide binding]; other site 454169005898 motif 1; other site 454169005899 active site 454169005900 motif 2; other site 454169005901 GAD domain; Region: GAD; pfam02938 454169005902 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 454169005903 active site 454169005904 motif 3; other site 454169005905 Isochorismatase family; Region: Isochorismatase; pfam00857 454169005906 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 454169005907 catalytic triad [active] 454169005908 conserved cis-peptide bond; other site 454169005909 hypothetical protein; Provisional; Region: PRK10302 454169005910 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 454169005911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169005912 S-adenosylmethionine binding site [chemical binding]; other site 454169005913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169005914 S-adenosylmethionine binding site [chemical binding]; other site 454169005915 copper homeostasis protein CutC; Provisional; Region: PRK11572 454169005916 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 454169005917 putative metal binding site [ion binding]; other site 454169005918 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 454169005919 arginyl-tRNA synthetase; Region: argS; TIGR00456 454169005920 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 454169005921 active site 454169005922 HIGH motif; other site 454169005923 KMSK motif region; other site 454169005924 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 454169005925 tRNA binding surface [nucleotide binding]; other site 454169005926 anticodon binding site; other site 454169005927 penicillin-binding protein 2; Provisional; Region: PRK10795 454169005928 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454169005929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454169005930 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 454169005931 Flagellar protein FlhE; Region: FlhE; pfam06366 454169005932 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 454169005933 FHIPEP family; Region: FHIPEP; pfam00771 454169005934 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 454169005935 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 454169005936 chemotaxis regulator CheZ; Provisional; Region: PRK11166 454169005937 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 454169005938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169005939 active site 454169005940 phosphorylation site [posttranslational modification] 454169005941 intermolecular recognition site; other site 454169005942 dimerization interface [polypeptide binding]; other site 454169005943 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 454169005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169005945 active site 454169005946 phosphorylation site [posttranslational modification] 454169005947 intermolecular recognition site; other site 454169005948 dimerization interface [polypeptide binding]; other site 454169005949 CheB methylesterase; Region: CheB_methylest; pfam01339 454169005950 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 454169005951 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 454169005952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169005953 S-adenosylmethionine binding site [chemical binding]; other site 454169005954 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 454169005955 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454169005956 dimer interface [polypeptide binding]; other site 454169005957 ligand binding site [chemical binding]; other site 454169005958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169005959 dimerization interface [polypeptide binding]; other site 454169005960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169005961 dimer interface [polypeptide binding]; other site 454169005962 putative CheW interface [polypeptide binding]; other site 454169005963 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 454169005964 putative CheA interaction surface; other site 454169005965 chemotaxis protein CheA; Provisional; Region: PRK10547 454169005966 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454169005967 putative binding surface; other site 454169005968 active site 454169005969 CheY binding; Region: CheY-binding; pfam09078 454169005970 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 454169005971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169005972 ATP binding site [chemical binding]; other site 454169005973 Mg2+ binding site [ion binding]; other site 454169005974 G-X-G motif; other site 454169005975 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 454169005976 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 454169005977 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 454169005978 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454169005979 ligand binding site [chemical binding]; other site 454169005980 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 454169005981 flagellar motor protein MotA; Validated; Region: PRK09110 454169005982 transcriptional activator FlhC; Provisional; Region: PRK12722 454169005983 transcriptional activator FlhD; Provisional; Region: PRK02909 454169005984 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454169005985 Ligand Binding Site [chemical binding]; other site 454169005986 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 454169005987 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 454169005988 active site 454169005989 homotetramer interface [polypeptide binding]; other site 454169005990 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 454169005991 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 454169005992 DJ-1 family protein; Region: not_thiJ; TIGR01383 454169005993 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 454169005994 conserved cys residue [active] 454169005995 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 454169005996 Ferritin-like domain; Region: Ferritin; pfam00210 454169005997 ferroxidase diiron center [ion binding]; other site 454169005998 hypothetical protein; Provisional; Region: PRK09273 454169005999 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 454169006000 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 454169006001 YecR-like lipoprotein; Region: YecR; pfam13992 454169006002 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 454169006003 Ferritin-like domain; Region: Ferritin; pfam00210 454169006004 ferroxidase diiron center [ion binding]; other site 454169006005 probable metal-binding protein; Region: matur_matur; TIGR03853 454169006006 tyrosine transporter TyrP; Provisional; Region: PRK15132 454169006007 aromatic amino acid transport protein; Region: araaP; TIGR00837 454169006008 hypothetical protein; Provisional; Region: PRK10396 454169006009 yecA family protein; Region: ygfB_yecA; TIGR02292 454169006010 SEC-C motif; Region: SEC-C; pfam02810 454169006011 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 454169006012 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 454169006013 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 454169006014 NlpC/P60 family; Region: NLPC_P60; cl17555 454169006015 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 454169006016 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 454169006017 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 454169006018 GIY-YIG motif/motif A; other site 454169006019 active site 454169006020 catalytic site [active] 454169006021 putative DNA binding site [nucleotide binding]; other site 454169006022 metal binding site [ion binding]; metal-binding site 454169006023 UvrB/uvrC motif; Region: UVR; pfam02151 454169006024 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 454169006025 Helix-hairpin-helix motif; Region: HHH; pfam00633 454169006026 response regulator; Provisional; Region: PRK09483 454169006027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169006028 active site 454169006029 phosphorylation site [posttranslational modification] 454169006030 intermolecular recognition site; other site 454169006031 dimerization interface [polypeptide binding]; other site 454169006032 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169006033 DNA binding residues [nucleotide binding] 454169006034 dimerization interface [polypeptide binding]; other site 454169006035 hypothetical protein; Provisional; Region: PRK10613 454169006036 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 454169006037 Autoinducer binding domain; Region: Autoind_bind; pfam03472 454169006038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169006039 DNA binding residues [nucleotide binding] 454169006040 dimerization interface [polypeptide binding]; other site 454169006041 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 454169006042 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454169006043 Walker A/P-loop; other site 454169006044 ATP binding site [chemical binding]; other site 454169006045 Q-loop/lid; other site 454169006046 ABC transporter signature motif; other site 454169006047 Walker B; other site 454169006048 D-loop; other site 454169006049 H-loop/switch region; other site 454169006050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454169006051 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169006052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169006053 dimer interface [polypeptide binding]; other site 454169006054 conserved gate region; other site 454169006055 putative PBP binding loops; other site 454169006056 ABC-ATPase subunit interface; other site 454169006057 D-cysteine desulfhydrase; Validated; Region: PRK03910 454169006058 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 454169006059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169006060 catalytic residue [active] 454169006061 cystine transporter subunit; Provisional; Region: PRK11260 454169006062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169006063 substrate binding pocket [chemical binding]; other site 454169006064 membrane-bound complex binding site; other site 454169006065 hinge residues; other site 454169006066 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 454169006067 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 454169006068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454169006069 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 454169006070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454169006071 DNA binding residues [nucleotide binding] 454169006072 flagellin; Validated; Region: PRK08026 454169006073 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 454169006074 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 454169006075 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 454169006076 flagellar capping protein; Reviewed; Region: fliD; PRK08032 454169006077 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 454169006078 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 454169006079 flagellar protein FliS; Validated; Region: fliS; PRK05685 454169006080 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 454169006081 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 454169006082 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 454169006083 active site 454169006084 Na/Ca binding site [ion binding]; other site 454169006085 catalytic site [active] 454169006086 lipoprotein; Provisional; Region: PRK10397 454169006087 putative inner membrane protein; Provisional; Region: PRK11099 454169006088 Sulphur transport; Region: Sulf_transp; pfam04143 454169006089 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 454169006090 CPxP motif; other site 454169006091 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 454169006092 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 454169006093 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 454169006094 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 454169006095 flagellar motor switch protein FliG; Region: fliG; TIGR00207 454169006096 FliG C-terminal domain; Region: FliG_C; pfam01706 454169006097 flagellar assembly protein H; Validated; Region: fliH; PRK05687 454169006098 Flagellar assembly protein FliH; Region: FliH; pfam02108 454169006099 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 454169006100 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 454169006101 Walker A motif/ATP binding site; other site 454169006102 Walker B motif; other site 454169006103 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 454169006104 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 454169006105 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 454169006106 flagellar hook-length control protein; Provisional; Region: PRK10118 454169006107 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 454169006108 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 454169006109 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 454169006110 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 454169006111 flagellar motor switch protein; Validated; Region: fliN; PRK05698 454169006112 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 454169006113 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 454169006114 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 454169006115 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 454169006116 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 454169006117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169006118 DNA binding residues [nucleotide binding] 454169006119 dimerization interface [polypeptide binding]; other site 454169006120 hypothetical protein; Provisional; Region: PRK10708 454169006121 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 454169006122 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 454169006123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169006124 active site 454169006125 motif I; other site 454169006126 motif II; other site 454169006127 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 454169006128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169006129 metal binding site [ion binding]; metal-binding site 454169006130 active site 454169006131 I-site; other site 454169006132 hypothetical protein; Provisional; Region: PRK10062 454169006133 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 454169006134 EamA-like transporter family; Region: EamA; pfam00892 454169006135 EamA-like transporter family; Region: EamA; pfam00892 454169006136 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 454169006137 additional DNA contacts [nucleotide binding]; other site 454169006138 mismatch recognition site; other site 454169006139 active site 454169006140 zinc binding site [ion binding]; other site 454169006141 DNA intercalation site [nucleotide binding]; other site 454169006142 DNA cytosine methylase; Provisional; Region: PRK10458 454169006143 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 454169006144 cofactor binding site; other site 454169006145 DNA binding site [nucleotide binding] 454169006146 substrate interaction site [chemical binding]; other site 454169006147 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 454169006148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454169006149 Zn2+ binding site [ion binding]; other site 454169006150 Mg2+ binding site [ion binding]; other site 454169006151 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169006152 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169006153 trimer interface [polypeptide binding]; other site 454169006154 eyelet of channel; other site 454169006155 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 454169006156 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 454169006157 active site 454169006158 DNA binding site [nucleotide binding] 454169006159 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 454169006160 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 454169006161 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 454169006162 Catalytic site [active] 454169006163 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 454169006164 putative protease; Region: PHA00666 454169006165 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 454169006166 Integrase; Region: Integrase_1; pfam12835 454169006167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 454169006168 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169006169 Sel1 repeat; Region: Sel1; pfam08238 454169006170 Sel1-like repeats; Region: SEL1; smart00671 454169006171 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 454169006172 AMP nucleosidase; Provisional; Region: PRK08292 454169006173 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 454169006174 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 454169006175 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 454169006176 MATE family multidrug exporter; Provisional; Region: PRK10189 454169006177 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 454169006178 L,D-transpeptidase; Provisional; Region: PRK10190 454169006179 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454169006180 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 454169006181 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 454169006182 putative dimer interface [polypeptide binding]; other site 454169006183 active site pocket [active] 454169006184 putative cataytic base [active] 454169006185 cobalamin synthase; Reviewed; Region: cobS; PRK00235 454169006186 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 454169006187 homotrimer interface [polypeptide binding]; other site 454169006188 Walker A motif; other site 454169006189 GTP binding site [chemical binding]; other site 454169006190 Walker B motif; other site 454169006191 cobyric acid synthase; Provisional; Region: PRK00784 454169006192 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 454169006193 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 454169006194 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 454169006195 catalytic triad [active] 454169006196 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 454169006197 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 454169006198 Walker A/P-loop; other site 454169006199 ATP binding site [chemical binding]; other site 454169006200 Q-loop/lid; other site 454169006201 ABC transporter signature motif; other site 454169006202 Walker B; other site 454169006203 D-loop; other site 454169006204 H-loop/switch region; other site 454169006205 cobalt transport protein CbiQ; Provisional; Region: PRK15485 454169006206 cobalt transport protein CbiN; Provisional; Region: PRK02898 454169006207 cobalt transport protein CbiM; Validated; Region: PRK08319 454169006208 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 454169006209 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 454169006210 active site 454169006211 SAM binding site [chemical binding]; other site 454169006212 homodimer interface [polypeptide binding]; other site 454169006213 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 454169006214 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 454169006215 active site 454169006216 C-terminal domain interface [polypeptide binding]; other site 454169006217 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 454169006218 active site 454169006219 N-terminal domain interface [polypeptide binding]; other site 454169006220 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 454169006221 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 454169006222 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 454169006223 active site 454169006224 SAM binding site [chemical binding]; other site 454169006225 homodimer interface [polypeptide binding]; other site 454169006226 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 454169006227 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 454169006228 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 454169006229 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 454169006230 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 454169006231 active site 454169006232 SAM binding site [chemical binding]; other site 454169006233 homodimer interface [polypeptide binding]; other site 454169006234 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 454169006235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169006236 S-adenosylmethionine binding site [chemical binding]; other site 454169006237 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 454169006238 active site 454169006239 putative homodimer interface [polypeptide binding]; other site 454169006240 SAM binding site [chemical binding]; other site 454169006241 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 454169006242 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 454169006243 Precorrin-8X methylmutase; Region: CbiC; pfam02570 454169006244 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 454169006245 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 454169006246 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 454169006247 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 454169006248 catalytic triad [active] 454169006249 Cobalamin riboswitch 454169006250 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 454169006251 Sensory domain found in PocR; Region: PocR; pfam10114 454169006252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169006253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169006254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169006255 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 454169006256 amphipathic channel; other site 454169006257 Asn-Pro-Ala signature motifs; other site 454169006258 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454169006259 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 454169006260 Hexamer interface [polypeptide binding]; other site 454169006261 Putative hexagonal pore residue; other site 454169006262 propanediol utilization protein PduB; Provisional; Region: PRK15415 454169006263 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 454169006264 putative hexamer interface [polypeptide binding]; other site 454169006265 putative hexagonal pore; other site 454169006266 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 454169006267 putative hexamer interface [polypeptide binding]; other site 454169006268 putative hexagonal pore; other site 454169006269 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 454169006270 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 454169006271 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 454169006272 alpha-beta subunit interface [polypeptide binding]; other site 454169006273 alpha-gamma subunit interface [polypeptide binding]; other site 454169006274 active site 454169006275 substrate and K+ binding site; other site 454169006276 K+ binding site [ion binding]; other site 454169006277 cobalamin binding site [chemical binding]; other site 454169006278 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 454169006279 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 454169006280 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 454169006281 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 454169006282 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454169006283 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 454169006284 Hexamer interface [polypeptide binding]; other site 454169006285 Putative hexagonal pore residue; other site 454169006286 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454169006287 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 454169006288 putative hexamer interface [polypeptide binding]; other site 454169006289 putative hexagonal pore; other site 454169006290 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 454169006291 Propanediol utilisation protein PduL; Region: PduL; pfam06130 454169006292 Propanediol utilisation protein PduL; Region: PduL; pfam06130 454169006293 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 454169006294 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 454169006295 Hexamer/Pentamer interface [polypeptide binding]; other site 454169006296 central pore; other site 454169006297 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 454169006298 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 454169006299 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 454169006300 putative catalytic cysteine [active] 454169006301 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 454169006302 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 454169006303 putative active site [active] 454169006304 metal binding site [ion binding]; metal-binding site 454169006305 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 454169006306 SLBB domain; Region: SLBB; pfam10531 454169006307 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 454169006308 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 454169006309 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 454169006310 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 454169006311 putative hexamer interface [polypeptide binding]; other site 454169006312 putative hexagonal pore; other site 454169006313 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 454169006314 putative hexamer interface [polypeptide binding]; other site 454169006315 putative hexagonal pore; other site 454169006316 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 454169006317 putative hexamer interface [polypeptide binding]; other site 454169006318 putative hexagonal pore; other site 454169006319 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 454169006320 G3 box; other site 454169006321 Switch II region; other site 454169006322 GTP/Mg2+ binding site [chemical binding]; other site 454169006323 G4 box; other site 454169006324 G5 box; other site 454169006325 propionate kinase; Reviewed; Region: PRK12397 454169006326 propionate/acetate kinase; Provisional; Region: PRK12379 454169006327 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 454169006328 hypothetical protein; Provisional; Region: PRK05423 454169006329 Predicted membrane protein [Function unknown]; Region: COG1289 454169006330 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454169006331 DNA gyrase inhibitor; Provisional; Region: PRK10016 454169006332 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 454169006333 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 454169006334 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 454169006335 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 454169006336 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 454169006337 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 454169006338 4Fe-4S binding domain; Region: Fer4; cl02805 454169006339 thiosulfate reductase PhsA; Provisional; Region: PRK15488 454169006340 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 454169006341 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 454169006342 putative [Fe4-S4] binding site [ion binding]; other site 454169006343 putative molybdopterin cofactor binding site [chemical binding]; other site 454169006344 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454169006345 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 454169006346 putative molybdopterin cofactor binding site; other site 454169006347 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 454169006348 SopA-like central domain; Region: SopA; pfam13981 454169006349 SopA-like catalytic domain; Region: SopA_C; pfam13979 454169006350 exonuclease I; Provisional; Region: sbcB; PRK11779 454169006351 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 454169006352 active site 454169006353 catalytic site [active] 454169006354 substrate binding site [chemical binding]; other site 454169006355 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 454169006356 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 454169006357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169006358 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 454169006359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169006360 dimerization interface [polypeptide binding]; other site 454169006361 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 454169006362 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 454169006363 putative NAD(P) binding site [chemical binding]; other site 454169006364 Histidine operon leader 454169006365 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 454169006366 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 454169006367 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 454169006368 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 454169006369 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 454169006370 NAD binding site [chemical binding]; other site 454169006371 dimerization interface [polypeptide binding]; other site 454169006372 product binding site; other site 454169006373 substrate binding site [chemical binding]; other site 454169006374 zinc binding site [ion binding]; other site 454169006375 catalytic residues [active] 454169006376 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 454169006377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169006378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169006379 homodimer interface [polypeptide binding]; other site 454169006380 catalytic residue [active] 454169006381 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 454169006382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169006383 active site 454169006384 motif I; other site 454169006385 motif II; other site 454169006386 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 454169006387 putative active site pocket [active] 454169006388 4-fold oligomerization interface [polypeptide binding]; other site 454169006389 metal binding residues [ion binding]; metal-binding site 454169006390 3-fold/trimer interface [polypeptide binding]; other site 454169006391 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 454169006392 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 454169006393 putative active site [active] 454169006394 oxyanion strand; other site 454169006395 catalytic triad [active] 454169006396 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 454169006397 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 454169006398 catalytic residues [active] 454169006399 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 454169006400 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 454169006401 substrate binding site [chemical binding]; other site 454169006402 glutamase interaction surface [polypeptide binding]; other site 454169006403 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 454169006404 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 454169006405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 454169006406 metal binding site [ion binding]; metal-binding site 454169006407 chain length determinant protein WzzB; Provisional; Region: PRK15471 454169006408 Chain length determinant protein; Region: Wzz; pfam02706 454169006409 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 454169006410 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 454169006411 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 454169006412 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 454169006413 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 454169006414 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454169006415 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 454169006416 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 454169006417 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 454169006418 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 454169006419 Bacterial sugar transferase; Region: Bac_transf; pfam02397 454169006420 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 454169006421 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 454169006422 active site 454169006423 substrate binding site [chemical binding]; other site 454169006424 metal binding site [ion binding]; metal-binding site 454169006425 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 454169006426 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 454169006427 Substrate binding site; other site 454169006428 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 454169006429 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454169006430 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 454169006431 active site 454169006432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169006433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 454169006434 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 454169006435 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 454169006436 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 454169006437 active site 454169006438 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 454169006439 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 454169006440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454169006441 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 454169006442 NAD(P) binding site [chemical binding]; other site 454169006443 active site 454169006444 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 454169006445 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 454169006446 inhibitor-cofactor binding pocket; inhibition site 454169006447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169006448 catalytic residue [active] 454169006449 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 454169006450 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 454169006451 NAD binding site [chemical binding]; other site 454169006452 homotetramer interface [polypeptide binding]; other site 454169006453 homodimer interface [polypeptide binding]; other site 454169006454 substrate binding site [chemical binding]; other site 454169006455 active site 454169006456 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 454169006457 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 454169006458 substrate binding site; other site 454169006459 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 454169006460 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454169006461 catalytic loop [active] 454169006462 iron binding site [ion binding]; other site 454169006463 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 454169006464 FAD binding pocket [chemical binding]; other site 454169006465 FAD binding motif [chemical binding]; other site 454169006466 phosphate binding motif [ion binding]; other site 454169006467 beta-alpha-beta structure motif; other site 454169006468 NAD binding pocket [chemical binding]; other site 454169006469 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 454169006470 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 454169006471 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 454169006472 substrate binding site; other site 454169006473 tetramer interface; other site 454169006474 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 454169006475 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 454169006476 NADP binding site [chemical binding]; other site 454169006477 active site 454169006478 putative substrate binding site [chemical binding]; other site 454169006479 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 454169006480 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 454169006481 NAD binding site [chemical binding]; other site 454169006482 substrate binding site [chemical binding]; other site 454169006483 homodimer interface [polypeptide binding]; other site 454169006484 active site 454169006485 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 454169006486 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 454169006487 active site 454169006488 tetramer interface; other site 454169006489 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 454169006490 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 454169006491 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 454169006492 putative ADP-binding pocket [chemical binding]; other site 454169006493 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 454169006494 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 454169006495 colanic acid exporter; Provisional; Region: PRK10459 454169006496 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 454169006497 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 454169006498 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 454169006499 phosphomannomutase CpsG; Provisional; Region: PRK15414 454169006500 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 454169006501 active site 454169006502 substrate binding site [chemical binding]; other site 454169006503 metal binding site [ion binding]; metal-binding site 454169006504 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 454169006505 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 454169006506 Substrate binding site; other site 454169006507 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 454169006508 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 454169006509 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 454169006510 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 454169006511 active site 454169006512 GDP-Mannose binding site [chemical binding]; other site 454169006513 dimer interface [polypeptide binding]; other site 454169006514 modified nudix motif 454169006515 metal binding site [ion binding]; metal-binding site 454169006516 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 454169006517 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 454169006518 NADP binding site [chemical binding]; other site 454169006519 active site 454169006520 putative substrate binding site [chemical binding]; other site 454169006521 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 454169006522 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 454169006523 NADP-binding site; other site 454169006524 homotetramer interface [polypeptide binding]; other site 454169006525 substrate binding site [chemical binding]; other site 454169006526 homodimer interface [polypeptide binding]; other site 454169006527 active site 454169006528 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 454169006529 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 454169006530 putative trimer interface [polypeptide binding]; other site 454169006531 putative active site [active] 454169006532 putative substrate binding site [chemical binding]; other site 454169006533 putative CoA binding site [chemical binding]; other site 454169006534 putative glycosyl transferase; Provisional; Region: PRK10063 454169006535 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 454169006536 metal-binding site 454169006537 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 454169006538 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 454169006539 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454169006540 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454169006541 putative acyl transferase; Provisional; Region: PRK10191 454169006542 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 454169006543 trimer interface [polypeptide binding]; other site 454169006544 active site 454169006545 substrate binding site [chemical binding]; other site 454169006546 CoA binding site [chemical binding]; other site 454169006547 putative glycosyl transferase; Provisional; Region: PRK10018 454169006548 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 454169006549 active site 454169006550 tyrosine kinase; Provisional; Region: PRK11519 454169006551 Chain length determinant protein; Region: Wzz; pfam02706 454169006552 Chain length determinant protein; Region: Wzz; cl15801 454169006553 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 454169006554 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 454169006555 Low molecular weight phosphatase family; Region: LMWPc; cd00115 454169006556 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 454169006557 active site 454169006558 polysaccharide export protein Wza; Provisional; Region: PRK15078 454169006559 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 454169006560 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 454169006561 FOG: CBS domain [General function prediction only]; Region: COG0517 454169006562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454169006563 Transporter associated domain; Region: CorC_HlyC; smart01091 454169006564 putative assembly protein; Provisional; Region: PRK10833 454169006565 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 454169006566 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 454169006567 trimer interface [polypeptide binding]; other site 454169006568 active site 454169006569 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 454169006570 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 454169006571 ATP-binding site [chemical binding]; other site 454169006572 Sugar specificity; other site 454169006573 Pyrimidine base specificity; other site 454169006574 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 454169006575 PAS domain S-box; Region: sensory_box; TIGR00229 454169006576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169006577 putative active site [active] 454169006578 heme pocket [chemical binding]; other site 454169006579 PAS domain S-box; Region: sensory_box; TIGR00229 454169006580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169006581 putative active site [active] 454169006582 heme pocket [chemical binding]; other site 454169006583 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454169006584 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169006585 metal binding site [ion binding]; metal-binding site 454169006586 active site 454169006587 I-site; other site 454169006588 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169006589 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 454169006590 AlkA N-terminal domain; Region: AlkA_N; pfam06029 454169006591 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 454169006592 minor groove reading motif; other site 454169006593 helix-hairpin-helix signature motif; other site 454169006594 substrate binding pocket [chemical binding]; other site 454169006595 active site 454169006596 putative chaperone; Provisional; Region: PRK11678 454169006597 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 454169006598 nucleotide binding site [chemical binding]; other site 454169006599 putative NEF/HSP70 interaction site [polypeptide binding]; other site 454169006600 SBD interface [polypeptide binding]; other site 454169006601 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 454169006602 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169006603 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169006604 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 454169006605 Protein export membrane protein; Region: SecD_SecF; cl14618 454169006606 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 454169006607 putative transporter; Provisional; Region: PRK10504 454169006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169006609 putative substrate translocation pore; other site 454169006610 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 454169006611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169006612 dimerization interface [polypeptide binding]; other site 454169006613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169006614 dimer interface [polypeptide binding]; other site 454169006615 phosphorylation site [posttranslational modification] 454169006616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169006617 ATP binding site [chemical binding]; other site 454169006618 Mg2+ binding site [ion binding]; other site 454169006619 G-X-G motif; other site 454169006620 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 454169006621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169006622 active site 454169006623 phosphorylation site [posttranslational modification] 454169006624 intermolecular recognition site; other site 454169006625 dimerization interface [polypeptide binding]; other site 454169006626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169006627 DNA binding site [nucleotide binding] 454169006628 PcfJ-like protein; Region: PcfJ; pfam14284 454169006629 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 454169006630 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 454169006631 putative protease; Provisional; Region: PRK15452 454169006632 Peptidase family U32; Region: Peptidase_U32; pfam01136 454169006633 type III secretion system protein; Provisional; Region: PRK15383 454169006634 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 454169006635 lipid kinase; Reviewed; Region: PRK13054 454169006636 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 454169006637 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 454169006638 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 454169006639 putative active site; other site 454169006640 catalytic residue [active] 454169006641 nucleoside transporter; Region: 2A0110; TIGR00889 454169006642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169006643 putative substrate translocation pore; other site 454169006644 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 454169006645 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169006646 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 454169006647 substrate binding site [chemical binding]; other site 454169006648 ATP binding site [chemical binding]; other site 454169006649 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454169006650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169006651 DNA-binding site [nucleotide binding]; DNA binding site 454169006652 UTRA domain; Region: UTRA; pfam07702 454169006653 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 454169006654 dimer interface [polypeptide binding]; other site 454169006655 substrate binding site [chemical binding]; other site 454169006656 ATP binding site [chemical binding]; other site 454169006657 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 454169006658 substrate binding site [chemical binding]; other site 454169006659 multimerization interface [polypeptide binding]; other site 454169006660 ATP binding site [chemical binding]; other site 454169006661 Predicted integral membrane protein [Function unknown]; Region: COG5455 454169006662 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 454169006663 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 454169006664 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 454169006665 PapC N-terminal domain; Region: PapC_N; pfam13954 454169006666 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169006667 PapC C-terminal domain; Region: PapC_C; pfam13953 454169006668 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 454169006669 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169006670 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169006671 fimbrial chaperone protein; Provisional; Region: PRK15220 454169006672 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 454169006673 antiporter inner membrane protein; Provisional; Region: PRK11670 454169006674 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 454169006675 Walker A motif; other site 454169006676 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 454169006677 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 454169006678 active site 454169006679 HIGH motif; other site 454169006680 KMSKS motif; other site 454169006681 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 454169006682 tRNA binding surface [nucleotide binding]; other site 454169006683 anticodon binding site; other site 454169006684 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 454169006685 dimer interface [polypeptide binding]; other site 454169006686 putative tRNA-binding site [nucleotide binding]; other site 454169006687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 454169006688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 454169006689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 454169006690 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 454169006691 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 454169006692 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 454169006693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169006694 active site 454169006695 phosphorylation site [posttranslational modification] 454169006696 intermolecular recognition site; other site 454169006697 dimerization interface [polypeptide binding]; other site 454169006698 LytTr DNA-binding domain; Region: LytTR; pfam04397 454169006699 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 454169006700 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 454169006701 GAF domain; Region: GAF; pfam01590 454169006702 Histidine kinase; Region: His_kinase; pfam06580 454169006703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169006704 ATP binding site [chemical binding]; other site 454169006705 Mg2+ binding site [ion binding]; other site 454169006706 G-X-G motif; other site 454169006707 transcriptional regulator MirA; Provisional; Region: PRK15043 454169006708 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 454169006709 DNA binding residues [nucleotide binding] 454169006710 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 454169006711 putative PBP binding loops; other site 454169006712 ABC-ATPase subunit interface; other site 454169006713 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 454169006714 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 454169006715 Walker A/P-loop; other site 454169006716 ATP binding site [chemical binding]; other site 454169006717 Q-loop/lid; other site 454169006718 ABC transporter signature motif; other site 454169006719 Walker B; other site 454169006720 D-loop; other site 454169006721 H-loop/switch region; other site 454169006722 CBS domain; Region: CBS; pfam00571 454169006723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169006724 dimer interface [polypeptide binding]; other site 454169006725 conserved gate region; other site 454169006726 ABC-ATPase subunit interface; other site 454169006727 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 454169006728 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 454169006729 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 454169006730 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 454169006731 D-lactate dehydrogenase; Provisional; Region: PRK11183 454169006732 FAD binding domain; Region: FAD_binding_4; pfam01565 454169006733 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 454169006734 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 454169006735 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 454169006736 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 454169006737 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454169006738 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 454169006739 oxidoreductase; Provisional; Region: PRK12743 454169006740 classical (c) SDRs; Region: SDR_c; cd05233 454169006741 NAD(P) binding site [chemical binding]; other site 454169006742 active site 454169006743 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 454169006744 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 454169006745 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 454169006746 FMN binding site [chemical binding]; other site 454169006747 active site 454169006748 catalytic residues [active] 454169006749 substrate binding site [chemical binding]; other site 454169006750 salicylate hydroxylase; Provisional; Region: PRK08163 454169006751 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454169006752 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 454169006753 maleylacetoacetate isomerase; Region: maiA; TIGR01262 454169006754 C-terminal domain interface [polypeptide binding]; other site 454169006755 GSH binding site (G-site) [chemical binding]; other site 454169006756 putative dimer interface [polypeptide binding]; other site 454169006757 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 454169006758 dimer interface [polypeptide binding]; other site 454169006759 N-terminal domain interface [polypeptide binding]; other site 454169006760 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 454169006761 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 454169006762 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 454169006763 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 454169006764 Cupin domain; Region: Cupin_2; pfam07883 454169006765 Cupin domain; Region: Cupin_2; pfam07883 454169006766 benzoate transport; Region: 2A0115; TIGR00895 454169006767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169006768 putative substrate translocation pore; other site 454169006769 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 454169006770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169006771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169006772 dimerization interface [polypeptide binding]; other site 454169006773 hypothetical protein; Provisional; Region: PRK01821 454169006774 hypothetical protein; Provisional; Region: PRK10711 454169006775 cytidine deaminase; Provisional; Region: PRK09027 454169006776 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 454169006777 active site 454169006778 catalytic motif [active] 454169006779 Zn binding site [ion binding]; other site 454169006780 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 454169006781 active site 454169006782 catalytic motif [active] 454169006783 Zn binding site [ion binding]; other site 454169006784 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454169006785 putative active site [active] 454169006786 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 454169006787 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 454169006788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454169006789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169006790 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 454169006791 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 454169006792 homodimer interface [polypeptide binding]; other site 454169006793 active site 454169006794 FMN binding site [chemical binding]; other site 454169006795 substrate binding site [chemical binding]; other site 454169006796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454169006797 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454169006798 TM-ABC transporter signature motif; other site 454169006799 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 454169006800 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 454169006801 Walker A/P-loop; other site 454169006802 ATP binding site [chemical binding]; other site 454169006803 Q-loop/lid; other site 454169006804 ABC transporter signature motif; other site 454169006805 Walker B; other site 454169006806 D-loop; other site 454169006807 H-loop/switch region; other site 454169006808 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 454169006809 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 454169006810 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 454169006811 ligand binding site [chemical binding]; other site 454169006812 calcium binding site [ion binding]; other site 454169006813 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 454169006814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169006815 DNA binding site [nucleotide binding] 454169006816 domain linker motif; other site 454169006817 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454169006818 dimerization interface (closed form) [polypeptide binding]; other site 454169006819 ligand binding site [chemical binding]; other site 454169006820 Predicted membrane protein [Function unknown]; Region: COG2311 454169006821 hypothetical protein; Provisional; Region: PRK10835 454169006822 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 454169006823 GTP cyclohydrolase I; Provisional; Region: PLN03044 454169006824 active site 454169006825 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 454169006826 S-formylglutathione hydrolase; Region: PLN02442 454169006827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169006828 non-specific DNA binding site [nucleotide binding]; other site 454169006829 salt bridge; other site 454169006830 sequence-specific DNA binding site [nucleotide binding]; other site 454169006831 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 454169006832 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454169006833 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454169006834 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 454169006835 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 454169006836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169006837 motif II; other site 454169006838 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 454169006839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169006840 putative substrate translocation pore; other site 454169006841 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 454169006842 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169006843 N-terminal plug; other site 454169006844 ligand-binding site [chemical binding]; other site 454169006845 lysine transporter; Provisional; Region: PRK10836 454169006846 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 454169006847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169006848 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 454169006849 putative dimerization interface [polypeptide binding]; other site 454169006850 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 454169006851 endonuclease IV; Provisional; Region: PRK01060 454169006852 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 454169006853 AP (apurinic/apyrimidinic) site pocket; other site 454169006854 DNA interaction; other site 454169006855 Metal-binding active site; metal-binding site 454169006856 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 454169006857 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 454169006858 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 454169006859 active site 454169006860 P-loop; other site 454169006861 phosphorylation site [posttranslational modification] 454169006862 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 454169006863 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 454169006864 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 454169006865 putative substrate binding site [chemical binding]; other site 454169006866 putative ATP binding site [chemical binding]; other site 454169006867 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 454169006868 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169006869 active site 454169006870 phosphorylation site [posttranslational modification] 454169006871 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454169006872 dimerization domain swap beta strand [polypeptide binding]; other site 454169006873 regulatory protein interface [polypeptide binding]; other site 454169006874 active site 454169006875 regulatory phosphorylation site [posttranslational modification]; other site 454169006876 sugar efflux transporter B; Provisional; Region: PRK15011 454169006877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169006878 putative substrate translocation pore; other site 454169006879 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 454169006880 elongation factor P; Provisional; Region: PRK04542 454169006881 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 454169006882 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 454169006883 RNA binding site [nucleotide binding]; other site 454169006884 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 454169006885 RNA binding site [nucleotide binding]; other site 454169006886 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 454169006887 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 454169006888 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 454169006889 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454169006890 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 454169006891 active site 454169006892 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 454169006893 NlpC/P60 family; Region: NLPC_P60; pfam00877 454169006894 phage resistance protein; Provisional; Region: PRK10551 454169006895 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454169006896 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169006897 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 454169006898 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 454169006899 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 454169006900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169006901 dimer interface [polypeptide binding]; other site 454169006902 conserved gate region; other site 454169006903 putative PBP binding loops; other site 454169006904 ABC-ATPase subunit interface; other site 454169006905 microcin C ABC transporter permease; Provisional; Region: PRK15021 454169006906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169006907 dimer interface [polypeptide binding]; other site 454169006908 conserved gate region; other site 454169006909 ABC-ATPase subunit interface; other site 454169006910 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 454169006911 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169006912 Walker A/P-loop; other site 454169006913 ATP binding site [chemical binding]; other site 454169006914 Q-loop/lid; other site 454169006915 ABC transporter signature motif; other site 454169006916 Walker B; other site 454169006917 D-loop; other site 454169006918 H-loop/switch region; other site 454169006919 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 454169006920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169006921 Walker A/P-loop; other site 454169006922 ATP binding site [chemical binding]; other site 454169006923 Q-loop/lid; other site 454169006924 ABC transporter signature motif; other site 454169006925 Walker B; other site 454169006926 D-loop; other site 454169006927 H-loop/switch region; other site 454169006928 hypothetical protein; Provisional; Region: PRK11835 454169006929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169006930 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 454169006931 putative substrate translocation pore; other site 454169006932 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 454169006933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169006934 RNA binding surface [nucleotide binding]; other site 454169006935 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 454169006936 active site 454169006937 uracil binding [chemical binding]; other site 454169006938 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 454169006939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169006940 ATP binding site [chemical binding]; other site 454169006941 putative Mg++ binding site [ion binding]; other site 454169006942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169006943 nucleotide binding region [chemical binding]; other site 454169006944 ATP-binding site [chemical binding]; other site 454169006945 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 454169006946 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 454169006947 5S rRNA interface [nucleotide binding]; other site 454169006948 CTC domain interface [polypeptide binding]; other site 454169006949 L16 interface [polypeptide binding]; other site 454169006950 Nucleoid-associated protein [General function prediction only]; Region: COG3081 454169006951 nucleoid-associated protein NdpA; Validated; Region: PRK00378 454169006952 hypothetical protein; Provisional; Region: PRK13689 454169006953 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 454169006954 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 454169006955 Sulfatase; Region: Sulfatase; cl17466 454169006956 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 454169006957 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 454169006958 Catalytic site [active] 454169006959 DinI-like family; Region: DinI; cl11630 454169006960 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454169006961 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454169006962 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 454169006963 Phage head maturation protease [General function prediction only]; Region: COG3740 454169006964 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 454169006965 Phage-related protein [Function unknown]; Region: COG4695; cl01923 454169006966 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 454169006967 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 454169006968 Protein of unknown function (DUF968); Region: DUF968; pfam06147 454169006969 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 454169006970 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 454169006971 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 454169006972 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 454169006973 Leucine-rich repeats; other site 454169006974 Substrate binding site [chemical binding]; other site 454169006975 DinI-like family; Region: DinI; cl11630 454169006976 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 454169006977 transcriptional regulator NarP; Provisional; Region: PRK10403 454169006978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169006979 active site 454169006980 phosphorylation site [posttranslational modification] 454169006981 intermolecular recognition site; other site 454169006982 dimerization interface [polypeptide binding]; other site 454169006983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169006984 DNA binding residues [nucleotide binding] 454169006985 dimerization interface [polypeptide binding]; other site 454169006986 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 454169006987 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 454169006988 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 454169006989 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 454169006990 catalytic residues [active] 454169006991 central insert; other site 454169006992 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 454169006993 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 454169006994 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 454169006995 heme exporter protein CcmC; Region: ccmC; TIGR01191 454169006996 heme exporter protein CcmB; Region: ccmB; TIGR01190 454169006997 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 454169006998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169006999 Walker A/P-loop; other site 454169007000 ATP binding site [chemical binding]; other site 454169007001 Q-loop/lid; other site 454169007002 ABC transporter signature motif; other site 454169007003 Walker B; other site 454169007004 D-loop; other site 454169007005 H-loop/switch region; other site 454169007006 cytochrome c-type protein NapC; Provisional; Region: PRK10617 454169007007 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 454169007008 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 454169007009 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 454169007010 4Fe-4S binding domain; Region: Fer4_5; pfam12801 454169007011 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169007012 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 454169007013 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 454169007014 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 454169007015 [4Fe-4S] binding site [ion binding]; other site 454169007016 molybdopterin cofactor binding site; other site 454169007017 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 454169007018 molybdopterin cofactor binding site; other site 454169007019 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 454169007020 4Fe-4S binding domain; Region: Fer4; cl02805 454169007021 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 454169007022 secondary substrate binding site; other site 454169007023 primary substrate binding site; other site 454169007024 inhibition loop; other site 454169007025 dimerization interface [polypeptide binding]; other site 454169007026 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 454169007027 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 454169007028 Walker A/P-loop; other site 454169007029 ATP binding site [chemical binding]; other site 454169007030 Q-loop/lid; other site 454169007031 ABC transporter signature motif; other site 454169007032 Walker B; other site 454169007033 D-loop; other site 454169007034 H-loop/switch region; other site 454169007035 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 454169007036 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 454169007037 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 454169007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169007039 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 454169007040 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 454169007041 DNA binding site [nucleotide binding] 454169007042 active site 454169007043 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 454169007044 ApbE family; Region: ApbE; pfam02424 454169007045 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454169007046 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454169007047 trimer interface [polypeptide binding]; other site 454169007048 eyelet of channel; other site 454169007049 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 454169007050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169007051 ATP binding site [chemical binding]; other site 454169007052 G-X-G motif; other site 454169007053 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454169007054 putative binding surface; other site 454169007055 active site 454169007056 transcriptional regulator RcsB; Provisional; Region: PRK10840 454169007057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169007058 active site 454169007059 phosphorylation site [posttranslational modification] 454169007060 intermolecular recognition site; other site 454169007061 dimerization interface [polypeptide binding]; other site 454169007062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169007063 DNA binding residues [nucleotide binding] 454169007064 dimerization interface [polypeptide binding]; other site 454169007065 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 454169007066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169007067 dimer interface [polypeptide binding]; other site 454169007068 phosphorylation site [posttranslational modification] 454169007069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169007070 ATP binding site [chemical binding]; other site 454169007071 Mg2+ binding site [ion binding]; other site 454169007072 G-X-G motif; other site 454169007073 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 454169007074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169007075 active site 454169007076 phosphorylation site [posttranslational modification] 454169007077 intermolecular recognition site; other site 454169007078 dimerization interface [polypeptide binding]; other site 454169007079 DNA gyrase subunit A; Validated; Region: PRK05560 454169007080 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 454169007081 CAP-like domain; other site 454169007082 active site 454169007083 primary dimer interface [polypeptide binding]; other site 454169007084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169007085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169007086 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169007087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169007088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169007089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169007090 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 454169007091 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 454169007092 active site pocket [active] 454169007093 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 454169007094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007095 putative substrate translocation pore; other site 454169007096 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454169007097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169007098 DNA-binding site [nucleotide binding]; DNA binding site 454169007099 FCD domain; Region: FCD; pfam07729 454169007100 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 454169007101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169007102 S-adenosylmethionine binding site [chemical binding]; other site 454169007103 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 454169007104 ATP cone domain; Region: ATP-cone; pfam03477 454169007105 Class I ribonucleotide reductase; Region: RNR_I; cd01679 454169007106 active site 454169007107 dimer interface [polypeptide binding]; other site 454169007108 catalytic residues [active] 454169007109 effector binding site; other site 454169007110 R2 peptide binding site; other site 454169007111 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 454169007112 dimer interface [polypeptide binding]; other site 454169007113 putative radical transfer pathway; other site 454169007114 diiron center [ion binding]; other site 454169007115 tyrosyl radical; other site 454169007116 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 454169007117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454169007118 catalytic loop [active] 454169007119 iron binding site [ion binding]; other site 454169007120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169007121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007122 putative substrate translocation pore; other site 454169007123 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 454169007124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169007125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169007126 dimerization interface [polypeptide binding]; other site 454169007127 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 454169007128 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 454169007129 active site 454169007130 catalytic site [active] 454169007131 metal binding site [ion binding]; metal-binding site 454169007132 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 454169007133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007134 putative substrate translocation pore; other site 454169007135 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 454169007136 hydroxyglutarate oxidase; Provisional; Region: PRK11728 454169007137 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 454169007138 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 454169007139 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 454169007140 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 454169007141 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169007142 Cysteine-rich domain; Region: CCG; pfam02754 454169007143 Cysteine-rich domain; Region: CCG; pfam02754 454169007144 deubiquitinase SseL; Provisional; Region: PRK14848 454169007145 hypothetical protein; Provisional; Region: PRK03673 454169007146 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 454169007147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007148 D-galactonate transporter; Region: 2A0114; TIGR00893 454169007149 putative substrate translocation pore; other site 454169007150 L-rhamnonate dehydratase; Provisional; Region: PRK15440 454169007151 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 454169007152 putative active site pocket [active] 454169007153 putative metal binding site [ion binding]; other site 454169007154 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454169007155 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454169007156 Bacterial transcriptional regulator; Region: IclR; pfam01614 454169007157 hypothetical protein; Provisional; Region: PRK03673 454169007158 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 454169007159 putative MPT binding site; other site 454169007160 Competence-damaged protein; Region: CinA; cl00666 454169007161 YfaZ precursor; Region: YfaZ; pfam07437 454169007162 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 454169007163 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 454169007164 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 454169007165 catalytic core [active] 454169007166 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 454169007167 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 454169007168 inhibitor-cofactor binding pocket; inhibition site 454169007169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169007170 catalytic residue [active] 454169007171 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 454169007172 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454169007173 Ligand binding site; other site 454169007174 Putative Catalytic site; other site 454169007175 DXD motif; other site 454169007176 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 454169007177 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 454169007178 active site 454169007179 substrate binding site [chemical binding]; other site 454169007180 cosubstrate binding site; other site 454169007181 catalytic site [active] 454169007182 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 454169007183 active site 454169007184 hexamer interface [polypeptide binding]; other site 454169007185 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 454169007186 NAD binding site [chemical binding]; other site 454169007187 substrate binding site [chemical binding]; other site 454169007188 active site 454169007189 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 454169007190 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 454169007191 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 454169007192 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 454169007193 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 454169007194 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 454169007195 signal transduction protein PmrD; Provisional; Region: PRK15450 454169007196 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 454169007197 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 454169007198 acyl-activating enzyme (AAE) consensus motif; other site 454169007199 putative AMP binding site [chemical binding]; other site 454169007200 putative active site [active] 454169007201 putative CoA binding site [chemical binding]; other site 454169007202 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 454169007203 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 454169007204 active site 454169007205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454169007206 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 454169007207 substrate binding site [chemical binding]; other site 454169007208 oxyanion hole (OAH) forming residues; other site 454169007209 trimer interface [polypeptide binding]; other site 454169007210 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 454169007211 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 454169007212 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 454169007213 dimer interface [polypeptide binding]; other site 454169007214 tetramer interface [polypeptide binding]; other site 454169007215 PYR/PP interface [polypeptide binding]; other site 454169007216 TPP binding site [chemical binding]; other site 454169007217 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 454169007218 TPP-binding site; other site 454169007219 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 454169007220 isochorismate synthases; Region: isochor_syn; TIGR00543 454169007221 hypothetical protein; Provisional; Region: PRK10404 454169007222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169007223 Coenzyme A binding pocket [chemical binding]; other site 454169007224 ribonuclease BN; Region: true_RNase_BN; TIGR02649 454169007225 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 454169007226 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 454169007227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169007228 active site 454169007229 phosphorylation site [posttranslational modification] 454169007230 intermolecular recognition site; other site 454169007231 dimerization interface [polypeptide binding]; other site 454169007232 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 454169007233 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454169007234 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 454169007235 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454169007236 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 454169007237 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 454169007238 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454169007239 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 454169007240 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 454169007241 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 454169007242 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 454169007243 4Fe-4S binding domain; Region: Fer4; pfam00037 454169007244 4Fe-4S binding domain; Region: Fer4; pfam00037 454169007245 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 454169007246 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 454169007247 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454169007248 catalytic loop [active] 454169007249 iron binding site [ion binding]; other site 454169007250 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 454169007251 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 454169007252 [4Fe-4S] binding site [ion binding]; other site 454169007253 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 454169007254 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 454169007255 SLBB domain; Region: SLBB; pfam10531 454169007256 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 454169007257 NADH dehydrogenase subunit E; Validated; Region: PRK07539 454169007258 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 454169007259 putative dimer interface [polypeptide binding]; other site 454169007260 [2Fe-2S] cluster binding site [ion binding]; other site 454169007261 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 454169007262 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 454169007263 NADH dehydrogenase subunit D; Validated; Region: PRK06075 454169007264 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 454169007265 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 454169007266 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 454169007267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169007268 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 454169007269 putative dimerization interface [polypeptide binding]; other site 454169007270 aminotransferase AlaT; Validated; Region: PRK09265 454169007271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169007272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169007273 homodimer interface [polypeptide binding]; other site 454169007274 catalytic residue [active] 454169007275 5'-nucleotidase; Provisional; Region: PRK03826 454169007276 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454169007277 transmembrane helices; other site 454169007278 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 454169007279 TrkA-C domain; Region: TrkA_C; pfam02080 454169007280 TrkA-C domain; Region: TrkA_C; pfam02080 454169007281 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454169007282 putative phosphatase; Provisional; Region: PRK11587 454169007283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169007284 motif II; other site 454169007285 hypothetical protein; Validated; Region: PRK05445 454169007286 hypothetical protein; Provisional; Region: PRK01816 454169007287 propionate/acetate kinase; Provisional; Region: PRK12379 454169007288 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 454169007289 phosphate acetyltransferase; Reviewed; Region: PRK05632 454169007290 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 454169007291 DRTGG domain; Region: DRTGG; pfam07085 454169007292 phosphate acetyltransferase; Region: pta; TIGR00651 454169007293 hypothetical protein; Provisional; Region: PRK11588 454169007294 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 454169007295 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 454169007296 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454169007297 PYR/PP interface [polypeptide binding]; other site 454169007298 dimer interface [polypeptide binding]; other site 454169007299 TPP binding site [chemical binding]; other site 454169007300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454169007301 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 454169007302 TPP-binding site [chemical binding]; other site 454169007303 dimer interface [polypeptide binding]; other site 454169007304 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 454169007305 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 454169007306 active site 454169007307 P-loop; other site 454169007308 phosphorylation site [posttranslational modification] 454169007309 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169007310 active site 454169007311 phosphorylation site [posttranslational modification] 454169007312 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454169007313 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169007314 DNA binding site [nucleotide binding] 454169007315 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454169007316 putative dimerization interface [polypeptide binding]; other site 454169007317 putative ligand binding site [chemical binding]; other site 454169007318 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 454169007319 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 454169007320 nudix motif; other site 454169007321 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 454169007322 active site 454169007323 metal binding site [ion binding]; metal-binding site 454169007324 homotetramer interface [polypeptide binding]; other site 454169007325 glutathione S-transferase; Provisional; Region: PRK15113 454169007326 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 454169007327 C-terminal domain interface [polypeptide binding]; other site 454169007328 GSH binding site (G-site) [chemical binding]; other site 454169007329 dimer interface [polypeptide binding]; other site 454169007330 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 454169007331 N-terminal domain interface [polypeptide binding]; other site 454169007332 putative dimer interface [polypeptide binding]; other site 454169007333 putative substrate binding pocket (H-site) [chemical binding]; other site 454169007334 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 454169007335 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 454169007336 C-terminal domain interface [polypeptide binding]; other site 454169007337 GSH binding site (G-site) [chemical binding]; other site 454169007338 dimer interface [polypeptide binding]; other site 454169007339 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 454169007340 N-terminal domain interface [polypeptide binding]; other site 454169007341 putative dimer interface [polypeptide binding]; other site 454169007342 active site 454169007343 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 454169007344 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 454169007345 putative NAD(P) binding site [chemical binding]; other site 454169007346 putative active site [active] 454169007347 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 454169007348 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454169007349 Walker A/P-loop; other site 454169007350 ATP binding site [chemical binding]; other site 454169007351 Q-loop/lid; other site 454169007352 ABC transporter signature motif; other site 454169007353 Walker B; other site 454169007354 D-loop; other site 454169007355 H-loop/switch region; other site 454169007356 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169007357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169007358 dimer interface [polypeptide binding]; other site 454169007359 conserved gate region; other site 454169007360 putative PBP binding loops; other site 454169007361 ABC-ATPase subunit interface; other site 454169007362 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454169007363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169007364 dimer interface [polypeptide binding]; other site 454169007365 conserved gate region; other site 454169007366 putative PBP binding loops; other site 454169007367 ABC-ATPase subunit interface; other site 454169007368 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 454169007369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169007370 substrate binding pocket [chemical binding]; other site 454169007371 membrane-bound complex binding site; other site 454169007372 hinge residues; other site 454169007373 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 454169007374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169007375 substrate binding pocket [chemical binding]; other site 454169007376 membrane-bound complex binding site; other site 454169007377 hinge residues; other site 454169007378 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 454169007379 Flavoprotein; Region: Flavoprotein; pfam02441 454169007380 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 454169007381 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 454169007382 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 454169007383 dimer interface [polypeptide binding]; other site 454169007384 active site 454169007385 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169007386 substrate binding site [chemical binding]; other site 454169007387 catalytic residue [active] 454169007388 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 454169007389 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 454169007390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 454169007391 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169007392 catalytic residue [active] 454169007393 PAS fold; Region: PAS_4; pfam08448 454169007394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 454169007395 putative active site [active] 454169007396 heme pocket [chemical binding]; other site 454169007397 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 454169007398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169007399 Walker A motif; other site 454169007400 ATP binding site [chemical binding]; other site 454169007401 Walker B motif; other site 454169007402 arginine finger; other site 454169007403 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454169007404 amidophosphoribosyltransferase; Provisional; Region: PRK09246 454169007405 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 454169007406 active site 454169007407 tetramer interface [polypeptide binding]; other site 454169007408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169007409 active site 454169007410 colicin V production protein; Provisional; Region: PRK10845 454169007411 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 454169007412 cell division protein DedD; Provisional; Region: PRK11633 454169007413 Sporulation related domain; Region: SPOR; pfam05036 454169007414 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 454169007415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454169007416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454169007417 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 454169007418 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 454169007419 hypothetical protein; Provisional; Region: PRK10847 454169007420 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454169007421 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 454169007422 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 454169007423 dimerization interface 3.5A [polypeptide binding]; other site 454169007424 active site 454169007425 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 454169007426 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 454169007427 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 454169007428 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 454169007429 ligand binding site [chemical binding]; other site 454169007430 NAD binding site [chemical binding]; other site 454169007431 catalytic site [active] 454169007432 homodimer interface [polypeptide binding]; other site 454169007433 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 454169007434 putative transporter; Provisional; Region: PRK12382 454169007435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007436 putative substrate translocation pore; other site 454169007437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169007438 non-specific DNA binding site [nucleotide binding]; other site 454169007439 salt bridge; other site 454169007440 sequence-specific DNA binding site [nucleotide binding]; other site 454169007441 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 454169007442 CAAX protease self-immunity; Region: Abi; pfam02517 454169007443 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 454169007444 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 454169007445 dimer interface [polypeptide binding]; other site 454169007446 active site 454169007447 Uncharacterized conserved protein [Function unknown]; Region: COG4121 454169007448 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 454169007449 YfcL protein; Region: YfcL; pfam08891 454169007450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 454169007451 hypothetical protein; Provisional; Region: PRK10621 454169007452 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 454169007453 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 454169007454 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 454169007455 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 454169007456 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 454169007457 Tetramer interface [polypeptide binding]; other site 454169007458 active site 454169007459 FMN-binding site [chemical binding]; other site 454169007460 HemK family putative methylases; Region: hemK_fam; TIGR00536 454169007461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169007462 S-adenosylmethionine binding site [chemical binding]; other site 454169007463 hypothetical protein; Provisional; Region: PRK04946 454169007464 Smr domain; Region: Smr; pfam01713 454169007465 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454169007466 catalytic core [active] 454169007467 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 454169007468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454169007469 substrate binding site [chemical binding]; other site 454169007470 oxyanion hole (OAH) forming residues; other site 454169007471 trimer interface [polypeptide binding]; other site 454169007472 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 454169007473 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 454169007474 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 454169007475 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 454169007476 dimer interface [polypeptide binding]; other site 454169007477 active site 454169007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 454169007479 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 454169007480 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 454169007481 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 454169007482 integrase; Provisional; Region: PRK09692 454169007483 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 454169007484 active site 454169007485 Int/Topo IB signature motif; other site 454169007486 AIPR protein; Region: AIPR; pfam10592 454169007487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 454169007488 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 454169007489 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 454169007490 active site 454169007491 metal binding site [ion binding]; metal-binding site 454169007492 interdomain interaction site; other site 454169007493 Domain of unknown function (DUF927); Region: DUF927; pfam06048 454169007494 Ash protein family; Region: Phage_ASH; pfam10554 454169007495 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 454169007496 outer membrane protease; Reviewed; Region: PRK10993 454169007497 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 454169007498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169007499 active site 454169007500 phosphorylation site [posttranslational modification] 454169007501 intermolecular recognition site; other site 454169007502 dimerization interface [polypeptide binding]; other site 454169007503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 454169007504 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454169007505 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 454169007506 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 454169007507 dimerization interface [polypeptide binding]; other site 454169007508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169007509 dimer interface [polypeptide binding]; other site 454169007510 phosphorylation site [posttranslational modification] 454169007511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169007512 ATP binding site [chemical binding]; other site 454169007513 Mg2+ binding site [ion binding]; other site 454169007514 G-X-G motif; other site 454169007515 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 454169007516 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454169007517 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 454169007518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007520 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 454169007521 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 454169007522 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 454169007523 putative acyl-acceptor binding pocket; other site 454169007524 Transposase IS200 like; Region: Y1_Tnp; pfam01797 454169007525 aminotransferase; Validated; Region: PRK08175 454169007526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169007527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169007528 homodimer interface [polypeptide binding]; other site 454169007529 catalytic residue [active] 454169007530 glucokinase; Provisional; Region: glk; PRK00292 454169007531 glucokinase, proteobacterial type; Region: glk; TIGR00749 454169007532 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 454169007533 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 454169007534 Cl- selectivity filter; other site 454169007535 Cl- binding residues [ion binding]; other site 454169007536 pore gating glutamate residue; other site 454169007537 dimer interface [polypeptide binding]; other site 454169007538 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 454169007539 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 454169007540 dimer interface [polypeptide binding]; other site 454169007541 PYR/PP interface [polypeptide binding]; other site 454169007542 TPP binding site [chemical binding]; other site 454169007543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454169007544 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 454169007545 TPP-binding site [chemical binding]; other site 454169007546 dimer interface [polypeptide binding]; other site 454169007547 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169007548 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169007549 active site 454169007550 catalytic tetrad [active] 454169007551 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 454169007552 manganese transport protein MntH; Reviewed; Region: PRK00701 454169007553 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 454169007554 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 454169007555 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 454169007556 Nucleoside recognition; Region: Gate; pfam07670 454169007557 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 454169007558 MASE1; Region: MASE1; pfam05231 454169007559 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454169007560 diguanylate cyclase; Region: GGDEF; smart00267 454169007561 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169007562 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 454169007563 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 454169007564 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 454169007565 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 454169007566 active site 454169007567 HIGH motif; other site 454169007568 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 454169007569 active site 454169007570 KMSKS motif; other site 454169007571 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 454169007572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169007573 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 454169007574 putative dimerization interface [polypeptide binding]; other site 454169007575 putative substrate binding pocket [chemical binding]; other site 454169007576 XapX domain; Region: XapX; TIGR03510 454169007577 nucleoside transporter; Region: 2A0110; TIGR00889 454169007578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169007579 putative substrate translocation pore; other site 454169007580 purine nucleoside phosphorylase; Provisional; Region: PRK08202 454169007581 hypothetical protein; Provisional; Region: PRK11528 454169007582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169007583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169007584 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 454169007585 putative dimerization interface [polypeptide binding]; other site 454169007586 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 454169007587 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 454169007588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 454169007589 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 454169007590 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 454169007591 nucleotide binding pocket [chemical binding]; other site 454169007592 K-X-D-G motif; other site 454169007593 catalytic site [active] 454169007594 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 454169007595 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 454169007596 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 454169007597 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 454169007598 Dimer interface [polypeptide binding]; other site 454169007599 BRCT sequence motif; other site 454169007600 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 454169007601 cell division protein ZipA; Provisional; Region: PRK03427 454169007602 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 454169007603 FtsZ protein binding site [polypeptide binding]; other site 454169007604 putative sulfate transport protein CysZ; Validated; Region: PRK04949 454169007605 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 454169007606 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 454169007607 dimer interface [polypeptide binding]; other site 454169007608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169007609 catalytic residue [active] 454169007610 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454169007611 dimerization domain swap beta strand [polypeptide binding]; other site 454169007612 regulatory protein interface [polypeptide binding]; other site 454169007613 active site 454169007614 regulatory phosphorylation site [posttranslational modification]; other site 454169007615 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 454169007616 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 454169007617 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 454169007618 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 454169007619 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 454169007620 HPr interaction site; other site 454169007621 glycerol kinase (GK) interaction site [polypeptide binding]; other site 454169007622 active site 454169007623 phosphorylation site [posttranslational modification] 454169007624 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 454169007625 dimer interface [polypeptide binding]; other site 454169007626 pyridoxamine kinase; Validated; Region: PRK05756 454169007627 pyridoxal binding site [chemical binding]; other site 454169007628 ATP binding site [chemical binding]; other site 454169007629 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 454169007630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169007631 DNA-binding site [nucleotide binding]; DNA binding site 454169007632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169007634 homodimer interface [polypeptide binding]; other site 454169007635 catalytic residue [active] 454169007636 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 454169007637 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 454169007638 catalytic triad [active] 454169007639 hypothetical protein; Provisional; Region: PRK10318 454169007640 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169007641 Sel1-like repeats; Region: SEL1; smart00671 454169007642 cysteine synthase B; Region: cysM; TIGR01138 454169007643 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 454169007644 dimer interface [polypeptide binding]; other site 454169007645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169007646 catalytic residue [active] 454169007647 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 454169007648 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 454169007649 Walker A/P-loop; other site 454169007650 ATP binding site [chemical binding]; other site 454169007651 Q-loop/lid; other site 454169007652 ABC transporter signature motif; other site 454169007653 Walker B; other site 454169007654 D-loop; other site 454169007655 H-loop/switch region; other site 454169007656 TOBE-like domain; Region: TOBE_3; pfam12857 454169007657 sulfate transport protein; Provisional; Region: cysT; CHL00187 454169007658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169007659 dimer interface [polypeptide binding]; other site 454169007660 conserved gate region; other site 454169007661 putative PBP binding loops; other site 454169007662 ABC-ATPase subunit interface; other site 454169007663 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 454169007664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169007665 dimer interface [polypeptide binding]; other site 454169007666 conserved gate region; other site 454169007667 putative PBP binding loops; other site 454169007668 ABC-ATPase subunit interface; other site 454169007669 thiosulfate transporter subunit; Provisional; Region: PRK10852 454169007670 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454169007671 short chain dehydrogenase; Provisional; Region: PRK08226 454169007672 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 454169007673 NAD binding site [chemical binding]; other site 454169007674 homotetramer interface [polypeptide binding]; other site 454169007675 homodimer interface [polypeptide binding]; other site 454169007676 active site 454169007677 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 454169007678 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 454169007679 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 454169007680 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 454169007681 putative acetyltransferase; Provisional; Region: PRK03624 454169007682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169007683 Coenzyme A binding pocket [chemical binding]; other site 454169007684 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 454169007685 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 454169007686 active site 454169007687 metal binding site [ion binding]; metal-binding site 454169007688 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 454169007689 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 454169007690 transcriptional regulator EutR; Provisional; Region: PRK10130 454169007691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169007692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169007693 carboxysome structural protein EutK; Provisional; Region: PRK15466 454169007694 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 454169007695 Hexamer interface [polypeptide binding]; other site 454169007696 Hexagonal pore residue; other site 454169007697 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 454169007698 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 454169007699 putative hexamer interface [polypeptide binding]; other site 454169007700 putative hexagonal pore; other site 454169007701 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 454169007702 putative hexamer interface [polypeptide binding]; other site 454169007703 putative hexagonal pore; other site 454169007704 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 454169007705 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 454169007706 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 454169007707 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 454169007708 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 454169007709 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 454169007710 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 454169007711 active site 454169007712 metal binding site [ion binding]; metal-binding site 454169007713 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 454169007714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169007715 nucleotide binding site [chemical binding]; other site 454169007716 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 454169007717 putative catalytic cysteine [active] 454169007718 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 454169007719 Hexamer/Pentamer interface [polypeptide binding]; other site 454169007720 central pore; other site 454169007721 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454169007722 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 454169007723 Hexamer interface [polypeptide binding]; other site 454169007724 Putative hexagonal pore residue; other site 454169007725 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 454169007726 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 454169007727 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 454169007728 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 454169007729 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 454169007730 G1 box; other site 454169007731 GTP/Mg2+ binding site [chemical binding]; other site 454169007732 G2 box; other site 454169007733 Switch I region; other site 454169007734 G3 box; other site 454169007735 Switch II region; other site 454169007736 G4 box; other site 454169007737 G5 box; other site 454169007738 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 454169007739 putative hexamer interface [polypeptide binding]; other site 454169007740 putative hexagonal pore; other site 454169007741 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 454169007742 Malic enzyme, N-terminal domain; Region: malic; pfam00390 454169007743 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 454169007744 putative NAD(P) binding site [chemical binding]; other site 454169007745 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 454169007746 transaldolase-like protein; Provisional; Region: PTZ00411 454169007747 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 454169007748 active site 454169007749 dimer interface [polypeptide binding]; other site 454169007750 catalytic residue [active] 454169007751 transketolase; Reviewed; Region: PRK12753 454169007752 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 454169007753 TPP-binding site [chemical binding]; other site 454169007754 dimer interface [polypeptide binding]; other site 454169007755 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454169007756 PYR/PP interface [polypeptide binding]; other site 454169007757 dimer interface [polypeptide binding]; other site 454169007758 TPP binding site [chemical binding]; other site 454169007759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454169007760 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 454169007761 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 454169007762 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 454169007763 dimer interface [polypeptide binding]; other site 454169007764 ADP-ribose binding site [chemical binding]; other site 454169007765 active site 454169007766 nudix motif; other site 454169007767 metal binding site [ion binding]; metal-binding site 454169007768 putative periplasmic esterase; Provisional; Region: PRK03642 454169007769 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 454169007770 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 454169007771 4Fe-4S binding domain; Region: Fer4; pfam00037 454169007772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454169007773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169007774 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 454169007775 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 454169007776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169007777 dimerization interface [polypeptide binding]; other site 454169007778 Histidine kinase; Region: HisKA_3; pfam07730 454169007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169007780 ATP binding site [chemical binding]; other site 454169007781 Mg2+ binding site [ion binding]; other site 454169007782 G-X-G motif; other site 454169007783 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 454169007784 Protein export membrane protein; Region: SecD_SecF; cl14618 454169007785 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 454169007786 ArsC family; Region: ArsC; pfam03960 454169007787 putative catalytic residues [active] 454169007788 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 454169007789 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 454169007790 metal binding site [ion binding]; metal-binding site 454169007791 dimer interface [polypeptide binding]; other site 454169007792 hypothetical protein; Provisional; Region: PRK13664 454169007793 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 454169007794 Helicase; Region: Helicase_RecD; pfam05127 454169007795 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 454169007796 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 454169007797 Predicted metalloprotease [General function prediction only]; Region: COG2321 454169007798 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 454169007799 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 454169007800 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 454169007801 ATP binding site [chemical binding]; other site 454169007802 active site 454169007803 substrate binding site [chemical binding]; other site 454169007804 lipoprotein; Provisional; Region: PRK11679 454169007805 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 454169007806 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 454169007807 dihydrodipicolinate synthase; Region: dapA; TIGR00674 454169007808 dimer interface [polypeptide binding]; other site 454169007809 active site 454169007810 catalytic residue [active] 454169007811 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 454169007812 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 454169007813 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 454169007814 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 454169007815 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 454169007816 catalytic triad [active] 454169007817 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 454169007818 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 454169007819 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454169007820 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 454169007821 Peptidase family M48; Region: Peptidase_M48; cl12018 454169007822 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 454169007823 ArsC family; Region: ArsC; pfam03960 454169007824 catalytic residues [active] 454169007825 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 454169007826 DNA replication initiation factor; Provisional; Region: PRK08084 454169007827 uracil transporter; Provisional; Region: PRK10720 454169007828 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169007829 active site 454169007830 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 454169007831 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 454169007832 dimerization interface [polypeptide binding]; other site 454169007833 putative ATP binding site [chemical binding]; other site 454169007834 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 454169007835 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 454169007836 active site 454169007837 substrate binding site [chemical binding]; other site 454169007838 cosubstrate binding site; other site 454169007839 catalytic site [active] 454169007840 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 454169007841 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 454169007842 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 454169007843 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 454169007844 putative active site [active] 454169007845 catalytic site [active] 454169007846 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 454169007847 domain interface [polypeptide binding]; other site 454169007848 active site 454169007849 catalytic site [active] 454169007850 exopolyphosphatase; Provisional; Region: PRK10854 454169007851 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169007852 nucleotide binding site [chemical binding]; other site 454169007853 MASE1; Region: MASE1; pfam05231 454169007854 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454169007855 diguanylate cyclase; Region: GGDEF; smart00267 454169007856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169007857 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 454169007858 Integrase core domain; Region: rve; pfam00665 454169007859 GMP synthase; Reviewed; Region: guaA; PRK00074 454169007860 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 454169007861 AMP/PPi binding site [chemical binding]; other site 454169007862 candidate oxyanion hole; other site 454169007863 catalytic triad [active] 454169007864 potential glutamine specificity residues [chemical binding]; other site 454169007865 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 454169007866 ATP Binding subdomain [chemical binding]; other site 454169007867 Ligand Binding sites [chemical binding]; other site 454169007868 Dimerization subdomain; other site 454169007869 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 454169007870 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 454169007871 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 454169007872 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 454169007873 active site 454169007874 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 454169007875 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 454169007876 generic binding surface II; other site 454169007877 generic binding surface I; other site 454169007878 outer membrane protein RatA; Provisional; Region: PRK15315 454169007879 Oxygen tolerance; Region: BatD; pfam13584 454169007880 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454169007881 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454169007882 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454169007883 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454169007884 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454169007885 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454169007886 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454169007887 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454169007888 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454169007889 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454169007890 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454169007891 intimin-like protein SinH; Provisional; Region: PRK15318 454169007892 intimin-like protein SinH; Provisional; Region: PRK15318 454169007893 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 454169007894 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 454169007895 GTP-binding protein Der; Reviewed; Region: PRK00093 454169007896 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 454169007897 G1 box; other site 454169007898 GTP/Mg2+ binding site [chemical binding]; other site 454169007899 Switch I region; other site 454169007900 G2 box; other site 454169007901 Switch II region; other site 454169007902 G3 box; other site 454169007903 G4 box; other site 454169007904 G5 box; other site 454169007905 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 454169007906 G1 box; other site 454169007907 GTP/Mg2+ binding site [chemical binding]; other site 454169007908 Switch I region; other site 454169007909 G2 box; other site 454169007910 G3 box; other site 454169007911 Switch II region; other site 454169007912 G4 box; other site 454169007913 G5 box; other site 454169007914 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 454169007915 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 454169007916 Trp docking motif [polypeptide binding]; other site 454169007917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 454169007918 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 454169007919 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 454169007920 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 454169007921 dimer interface [polypeptide binding]; other site 454169007922 motif 1; other site 454169007923 active site 454169007924 motif 2; other site 454169007925 motif 3; other site 454169007926 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 454169007927 anticodon binding site; other site 454169007928 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 454169007929 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 454169007930 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 454169007931 cytoskeletal protein RodZ; Provisional; Region: PRK10856 454169007932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169007933 non-specific DNA binding site [nucleotide binding]; other site 454169007934 salt bridge; other site 454169007935 sequence-specific DNA binding site [nucleotide binding]; other site 454169007936 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 454169007937 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 454169007938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169007939 FeS/SAM binding site; other site 454169007940 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 454169007941 active site 454169007942 multimer interface [polypeptide binding]; other site 454169007943 4Fe-4S binding domain; Region: Fer4; pfam00037 454169007944 hydrogenase 4 subunit H; Validated; Region: PRK08222 454169007945 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454169007946 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454169007947 4Fe-4S binding domain; Region: Fer4; pfam00037 454169007948 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454169007949 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454169007950 putative [Fe4-S4] binding site [ion binding]; other site 454169007951 putative molybdopterin cofactor binding site [chemical binding]; other site 454169007952 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454169007953 putative molybdopterin cofactor binding site; other site 454169007954 penicillin-binding protein 1C; Provisional; Region: PRK11240 454169007955 Transglycosylase; Region: Transgly; pfam00912 454169007956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 454169007957 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 454169007958 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 454169007959 MG2 domain; Region: A2M_N; pfam01835 454169007960 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 454169007961 surface patch; other site 454169007962 thioester region; other site 454169007963 specificity defining residues; other site 454169007964 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 454169007965 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 454169007966 active site residue [active] 454169007967 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 454169007968 active site residue [active] 454169007969 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 454169007970 aminopeptidase B; Provisional; Region: PRK05015 454169007971 Peptidase; Region: DUF3663; pfam12404 454169007972 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 454169007973 interface (dimer of trimers) [polypeptide binding]; other site 454169007974 Substrate-binding/catalytic site; other site 454169007975 Zn-binding sites [ion binding]; other site 454169007976 hypothetical protein; Provisional; Region: PRK10721 454169007977 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 454169007978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454169007979 catalytic loop [active] 454169007980 iron binding site [ion binding]; other site 454169007981 chaperone protein HscA; Provisional; Region: hscA; PRK05183 454169007982 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 454169007983 nucleotide binding site [chemical binding]; other site 454169007984 putative NEF/HSP70 interaction site [polypeptide binding]; other site 454169007985 SBD interface [polypeptide binding]; other site 454169007986 co-chaperone HscB; Provisional; Region: hscB; PRK05014 454169007987 DnaJ domain; Region: DnaJ; pfam00226 454169007988 HSP70 interaction site [polypeptide binding]; other site 454169007989 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 454169007990 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 454169007991 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 454169007992 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 454169007993 trimerization site [polypeptide binding]; other site 454169007994 active site 454169007995 cysteine desulfurase; Provisional; Region: PRK14012 454169007996 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 454169007997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169007998 catalytic residue [active] 454169007999 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 454169008000 Rrf2 family protein; Region: rrf2_super; TIGR00738 454169008001 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 454169008002 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 454169008003 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 454169008004 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 454169008005 active site 454169008006 dimerization interface [polypeptide binding]; other site 454169008007 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 454169008008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454169008009 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 454169008010 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169008011 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 454169008012 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 454169008013 FAD binding pocket [chemical binding]; other site 454169008014 FAD binding motif [chemical binding]; other site 454169008015 phosphate binding motif [ion binding]; other site 454169008016 beta-alpha-beta structure motif; other site 454169008017 NAD binding pocket [chemical binding]; other site 454169008018 Iron coordination center [ion binding]; other site 454169008019 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 454169008020 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454169008021 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169008022 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 454169008023 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 454169008024 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 454169008025 PRD domain; Region: PRD; pfam00874 454169008026 PRD domain; Region: PRD; pfam00874 454169008027 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 454169008028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008029 putative substrate translocation pore; other site 454169008030 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 454169008031 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 454169008032 dimer interface [polypeptide binding]; other site 454169008033 active site 454169008034 glycine-pyridoxal phosphate binding site [chemical binding]; other site 454169008035 folate binding site [chemical binding]; other site 454169008036 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 454169008037 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 454169008038 heme-binding site [chemical binding]; other site 454169008039 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 454169008040 FAD binding pocket [chemical binding]; other site 454169008041 FAD binding motif [chemical binding]; other site 454169008042 phosphate binding motif [ion binding]; other site 454169008043 beta-alpha-beta structure motif; other site 454169008044 NAD binding pocket [chemical binding]; other site 454169008045 Heme binding pocket [chemical binding]; other site 454169008046 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 454169008047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169008048 DNA binding site [nucleotide binding] 454169008049 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 454169008050 lysine decarboxylase CadA; Provisional; Region: PRK15400 454169008051 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454169008052 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454169008053 homodimer interface [polypeptide binding]; other site 454169008054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169008055 catalytic residue [active] 454169008056 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454169008057 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 454169008058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008059 putative substrate translocation pore; other site 454169008060 POT family; Region: PTR2; pfam00854 454169008061 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 454169008062 Nitrogen regulatory protein P-II; Region: P-II; smart00938 454169008063 response regulator GlrR; Provisional; Region: PRK15115 454169008064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169008065 active site 454169008066 phosphorylation site [posttranslational modification] 454169008067 intermolecular recognition site; other site 454169008068 dimerization interface [polypeptide binding]; other site 454169008069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169008070 Walker A motif; other site 454169008071 ATP binding site [chemical binding]; other site 454169008072 Walker B motif; other site 454169008073 arginine finger; other site 454169008074 hypothetical protein; Provisional; Region: PRK10722 454169008075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 454169008076 HAMP domain; Region: HAMP; pfam00672 454169008077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169008078 dimer interface [polypeptide binding]; other site 454169008079 phosphorylation site [posttranslational modification] 454169008080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169008081 ATP binding site [chemical binding]; other site 454169008082 Mg2+ binding site [ion binding]; other site 454169008083 G-X-G motif; other site 454169008084 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 454169008085 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 454169008086 dimerization interface [polypeptide binding]; other site 454169008087 ATP binding site [chemical binding]; other site 454169008088 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 454169008089 dimerization interface [polypeptide binding]; other site 454169008090 ATP binding site [chemical binding]; other site 454169008091 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 454169008092 putative active site [active] 454169008093 catalytic triad [active] 454169008094 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 454169008095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169008096 substrate binding pocket [chemical binding]; other site 454169008097 membrane-bound complex binding site; other site 454169008098 hinge residues; other site 454169008099 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169008100 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169008101 catalytic residue [active] 454169008102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 454169008103 nucleoside/Zn binding site; other site 454169008104 dimer interface [polypeptide binding]; other site 454169008105 catalytic motif [active] 454169008106 hypothetical protein; Provisional; Region: PRK11590 454169008107 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 454169008108 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 454169008109 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454169008110 active site turn [active] 454169008111 phosphorylation site [posttranslational modification] 454169008112 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454169008113 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 454169008114 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 454169008115 putative active site [active] 454169008116 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 454169008117 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 454169008118 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 454169008119 putative active site [active] 454169008120 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 454169008121 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 454169008122 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 454169008123 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 454169008124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008125 putative substrate translocation pore; other site 454169008126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169008127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169008128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169008129 dimerization interface [polypeptide binding]; other site 454169008130 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 454169008131 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 454169008132 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 454169008133 active site 454169008134 hydrophilic channel; other site 454169008135 dimerization interface [polypeptide binding]; other site 454169008136 catalytic residues [active] 454169008137 active site lid [active] 454169008138 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 454169008139 Recombination protein O N terminal; Region: RecO_N; pfam11967 454169008140 Recombination protein O C terminal; Region: RecO_C; pfam02565 454169008141 GTPase Era; Reviewed; Region: era; PRK00089 454169008142 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 454169008143 G1 box; other site 454169008144 GTP/Mg2+ binding site [chemical binding]; other site 454169008145 Switch I region; other site 454169008146 G2 box; other site 454169008147 Switch II region; other site 454169008148 G3 box; other site 454169008149 G4 box; other site 454169008150 G5 box; other site 454169008151 KH domain; Region: KH_2; pfam07650 454169008152 ribonuclease III; Reviewed; Region: rnc; PRK00102 454169008153 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 454169008154 dimerization interface [polypeptide binding]; other site 454169008155 active site 454169008156 metal binding site [ion binding]; metal-binding site 454169008157 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 454169008158 dsRNA binding site [nucleotide binding]; other site 454169008159 rncO 454169008160 signal peptidase I; Provisional; Region: PRK10861 454169008161 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 454169008162 Catalytic site [active] 454169008163 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 454169008164 GTP-binding protein LepA; Provisional; Region: PRK05433 454169008165 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 454169008166 G1 box; other site 454169008167 putative GEF interaction site [polypeptide binding]; other site 454169008168 GTP/Mg2+ binding site [chemical binding]; other site 454169008169 Switch I region; other site 454169008170 G2 box; other site 454169008171 G3 box; other site 454169008172 Switch II region; other site 454169008173 G4 box; other site 454169008174 G5 box; other site 454169008175 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 454169008176 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 454169008177 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 454169008178 SoxR reducing system protein RseC; Provisional; Region: PRK10862 454169008179 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 454169008180 anti-sigma E factor; Provisional; Region: rseB; PRK09455 454169008181 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 454169008182 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 454169008183 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 454169008184 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 454169008185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454169008186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454169008187 DNA binding residues [nucleotide binding] 454169008188 L-aspartate oxidase; Provisional; Region: PRK09077 454169008189 L-aspartate oxidase; Provisional; Region: PRK06175 454169008190 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 454169008191 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 454169008192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169008193 S-adenosylmethionine binding site [chemical binding]; other site 454169008194 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 454169008195 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454169008196 ATP binding site [chemical binding]; other site 454169008197 Mg++ binding site [ion binding]; other site 454169008198 motif III; other site 454169008199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169008200 nucleotide binding region [chemical binding]; other site 454169008201 ATP-binding site [chemical binding]; other site 454169008202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169008203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169008204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169008205 dimerization interface [polypeptide binding]; other site 454169008206 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 454169008207 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 454169008208 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 454169008209 ligand binding site [chemical binding]; other site 454169008210 active site 454169008211 UGI interface [polypeptide binding]; other site 454169008212 catalytic site [active] 454169008213 putative methyltransferase; Provisional; Region: PRK10864 454169008214 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 454169008215 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 454169008216 thioredoxin 2; Provisional; Region: PRK10996 454169008217 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 454169008218 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 454169008219 catalytic residues [active] 454169008220 Uncharacterized conserved protein [Function unknown]; Region: COG3148 454169008221 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 454169008222 CoA binding domain; Region: CoA_binding_2; pfam13380 454169008223 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 454169008224 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 454169008225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 454169008226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169008227 Coenzyme A binding pocket [chemical binding]; other site 454169008228 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 454169008229 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 454169008230 domain interface [polypeptide binding]; other site 454169008231 putative active site [active] 454169008232 catalytic site [active] 454169008233 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 454169008234 domain interface [polypeptide binding]; other site 454169008235 putative active site [active] 454169008236 catalytic site [active] 454169008237 lipoprotein; Provisional; Region: PRK10759 454169008238 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 454169008239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008240 putative substrate translocation pore; other site 454169008241 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 454169008242 protein disaggregation chaperone; Provisional; Region: PRK10865 454169008243 Clp amino terminal domain; Region: Clp_N; pfam02861 454169008244 Clp amino terminal domain; Region: Clp_N; pfam02861 454169008245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169008246 Walker A motif; other site 454169008247 ATP binding site [chemical binding]; other site 454169008248 Walker B motif; other site 454169008249 arginine finger; other site 454169008250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169008251 Walker A motif; other site 454169008252 ATP binding site [chemical binding]; other site 454169008253 Walker B motif; other site 454169008254 arginine finger; other site 454169008255 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 454169008256 hypothetical protein; Provisional; Region: PRK10723 454169008257 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 454169008258 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 454169008259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169008260 RNA binding surface [nucleotide binding]; other site 454169008261 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 454169008262 active site 454169008263 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 454169008264 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 454169008265 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 454169008266 30S subunit binding site; other site 454169008267 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 454169008268 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 454169008269 Prephenate dehydratase; Region: PDT; pfam00800 454169008270 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 454169008271 putative L-Phe binding site [chemical binding]; other site 454169008272 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 454169008273 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 454169008274 Chorismate mutase type II; Region: CM_2; cl00693 454169008275 prephenate dehydrogenase; Validated; Region: PRK08507 454169008276 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 454169008277 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454169008278 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 454169008279 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 454169008280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169008281 metal binding site [ion binding]; metal-binding site 454169008282 active site 454169008283 I-site; other site 454169008284 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 454169008285 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 454169008286 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 454169008287 RimM N-terminal domain; Region: RimM; pfam01782 454169008288 PRC-barrel domain; Region: PRC; pfam05239 454169008289 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 454169008290 signal recognition particle protein; Provisional; Region: PRK10867 454169008291 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 454169008292 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 454169008293 P loop; other site 454169008294 GTP binding site [chemical binding]; other site 454169008295 Signal peptide binding domain; Region: SRP_SPB; pfam02978 454169008296 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 454169008297 hypothetical protein; Provisional; Region: PRK11573 454169008298 Domain of unknown function DUF21; Region: DUF21; pfam01595 454169008299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454169008300 Transporter associated domain; Region: CorC_HlyC; smart01091 454169008301 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 454169008302 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 454169008303 dimer interface [polypeptide binding]; other site 454169008304 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 454169008305 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 454169008306 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 454169008307 recombination and repair protein; Provisional; Region: PRK10869 454169008308 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 454169008309 Walker A/P-loop; other site 454169008310 ATP binding site [chemical binding]; other site 454169008311 Q-loop/lid; other site 454169008312 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 454169008313 ABC transporter signature motif; other site 454169008314 Walker B; other site 454169008315 D-loop; other site 454169008316 H-loop/switch region; other site 454169008317 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 454169008318 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 454169008319 hypothetical protein; Validated; Region: PRK01777 454169008320 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 454169008321 putative coenzyme Q binding site [chemical binding]; other site 454169008322 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 454169008323 SmpB-tmRNA interface; other site 454169008324 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008325 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008326 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008327 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008328 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008329 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008330 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008331 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008332 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008333 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008334 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008335 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169008336 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008337 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008338 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169008339 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008340 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169008341 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 454169008342 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 454169008343 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 454169008344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169008345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169008346 Walker A/P-loop; other site 454169008347 ATP binding site [chemical binding]; other site 454169008348 Q-loop/lid; other site 454169008349 ABC transporter signature motif; other site 454169008350 Walker B; other site 454169008351 D-loop; other site 454169008352 H-loop/switch region; other site 454169008353 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 454169008354 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169008355 SEC-C motif; Region: SEC-C; pfam02810 454169008356 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 454169008357 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 454169008358 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 454169008359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 454169008360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169008361 non-specific DNA binding site [nucleotide binding]; other site 454169008362 salt bridge; other site 454169008363 sequence-specific DNA binding site [nucleotide binding]; other site 454169008364 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 454169008365 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 454169008366 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 454169008367 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 454169008368 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 454169008369 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 454169008370 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454169008371 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454169008372 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454169008373 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 454169008374 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 454169008375 active site 454169008376 dimer interface [polypeptide binding]; other site 454169008377 magnesium binding site [ion binding]; other site 454169008378 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 454169008379 tetramer interface [polypeptide binding]; other site 454169008380 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 454169008381 active site 454169008382 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 454169008383 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 454169008384 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454169008385 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 454169008386 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454169008387 active site turn [active] 454169008388 phosphorylation site [posttranslational modification] 454169008389 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 454169008390 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454169008391 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 454169008392 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 454169008393 Integrase; Region: Integrase_1; pfam12835 454169008394 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 454169008395 DNA-binding interface [nucleotide binding]; DNA binding site 454169008396 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 454169008397 Family description; Region: UvrD_C_2; pfam13538 454169008398 Transposase; Region: HTH_Tnp_1; cl17663 454169008399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 454169008400 putative transposase OrfB; Reviewed; Region: PHA02517 454169008401 HTH-like domain; Region: HTH_21; pfam13276 454169008402 Integrase core domain; Region: rve; pfam00665 454169008403 Integrase core domain; Region: rve_2; pfam13333 454169008404 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 454169008405 flagellin; Validated; Region: PRK08026 454169008406 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 454169008407 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 454169008408 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 454169008409 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 454169008410 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 454169008411 catalytic residues [active] 454169008412 catalytic nucleophile [active] 454169008413 Presynaptic Site I dimer interface [polypeptide binding]; other site 454169008414 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 454169008415 Synaptic Flat tetramer interface [polypeptide binding]; other site 454169008416 Synaptic Site I dimer interface [polypeptide binding]; other site 454169008417 DNA binding site [nucleotide binding] 454169008418 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 454169008419 DNA-binding interface [nucleotide binding]; DNA binding site 454169008420 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 454169008421 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 454169008422 homodimer interface [polypeptide binding]; other site 454169008423 active site 454169008424 TDP-binding site; other site 454169008425 acceptor substrate-binding pocket; other site 454169008426 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169008427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169008428 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 454169008429 Walker A/P-loop; other site 454169008430 ATP binding site [chemical binding]; other site 454169008431 Q-loop/lid; other site 454169008432 ABC transporter signature motif; other site 454169008433 Walker B; other site 454169008434 D-loop; other site 454169008435 H-loop/switch region; other site 454169008436 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 454169008437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454169008438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169008439 Walker A/P-loop; other site 454169008440 ATP binding site [chemical binding]; other site 454169008441 Q-loop/lid; other site 454169008442 ABC transporter signature motif; other site 454169008443 Walker B; other site 454169008444 D-loop; other site 454169008445 H-loop/switch region; other site 454169008446 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 454169008447 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 454169008448 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454169008449 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 454169008450 outer membrane receptor FepA; Provisional; Region: PRK13528 454169008451 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169008452 N-terminal plug; other site 454169008453 ligand-binding site [chemical binding]; other site 454169008454 secreted effector protein PipB2; Provisional; Region: PRK15196 454169008455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169008456 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169008457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169008458 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169008459 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454169008460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 454169008461 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 454169008462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 454169008463 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 454169008464 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 454169008465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 454169008466 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 454169008467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169008468 dimer interface [polypeptide binding]; other site 454169008469 phosphorylation site [posttranslational modification] 454169008470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169008471 ATP binding site [chemical binding]; other site 454169008472 Mg2+ binding site [ion binding]; other site 454169008473 G-X-G motif; other site 454169008474 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 454169008475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169008476 active site 454169008477 phosphorylation site [posttranslational modification] 454169008478 intermolecular recognition site; other site 454169008479 dimerization interface [polypeptide binding]; other site 454169008480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169008481 DNA binding site [nucleotide binding] 454169008482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 454169008483 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 454169008484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 454169008485 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 454169008486 substrate binding pocket [chemical binding]; other site 454169008487 active site 454169008488 iron coordination sites [ion binding]; other site 454169008489 Predicted dehydrogenase [General function prediction only]; Region: COG0579 454169008490 hydroxyglutarate oxidase; Provisional; Region: PRK11728 454169008491 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 454169008492 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 454169008493 tetramerization interface [polypeptide binding]; other site 454169008494 NAD(P) binding site [chemical binding]; other site 454169008495 catalytic residues [active] 454169008496 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 454169008497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454169008498 inhibitor-cofactor binding pocket; inhibition site 454169008499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169008500 catalytic residue [active] 454169008501 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 454169008502 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 454169008503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169008504 DNA-binding site [nucleotide binding]; DNA binding site 454169008505 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454169008506 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 454169008507 bacterial OsmY and nodulation domain; Region: BON; smart00749 454169008508 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169008509 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 454169008510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169008511 dimerization interface [polypeptide binding]; other site 454169008512 putative DNA binding site [nucleotide binding]; other site 454169008513 putative Zn2+ binding site [ion binding]; other site 454169008514 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 454169008515 active site residue [active] 454169008516 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 454169008517 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 454169008518 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 454169008519 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 454169008520 hypothetical protein; Provisional; Region: PRK10556 454169008521 hypothetical protein; Provisional; Region: PRK10132 454169008522 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 454169008523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169008524 DNA-binding site [nucleotide binding]; DNA binding site 454169008525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169008526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169008527 homodimer interface [polypeptide binding]; other site 454169008528 catalytic residue [active] 454169008529 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 454169008530 Uncharacterized conserved protein [Function unknown]; Region: COG2128 454169008531 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 454169008532 catalytic residues [active] 454169008533 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 454169008534 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 454169008535 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 454169008536 Class I ribonucleotide reductase; Region: RNR_I; cd01679 454169008537 active site 454169008538 dimer interface [polypeptide binding]; other site 454169008539 catalytic residues [active] 454169008540 effector binding site; other site 454169008541 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 454169008542 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 454169008543 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 454169008544 dimer interface [polypeptide binding]; other site 454169008545 putative radical transfer pathway; other site 454169008546 diiron center [ion binding]; other site 454169008547 tyrosyl radical; other site 454169008548 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 454169008549 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 454169008550 Walker A/P-loop; other site 454169008551 ATP binding site [chemical binding]; other site 454169008552 Q-loop/lid; other site 454169008553 ABC transporter signature motif; other site 454169008554 Walker B; other site 454169008555 D-loop; other site 454169008556 H-loop/switch region; other site 454169008557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 454169008558 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 454169008559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169008560 dimer interface [polypeptide binding]; other site 454169008561 conserved gate region; other site 454169008562 putative PBP binding loops; other site 454169008563 ABC-ATPase subunit interface; other site 454169008564 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 454169008565 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 454169008566 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454169008567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008568 transcriptional repressor MprA; Provisional; Region: PRK10870 454169008569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454169008570 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 454169008571 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169008572 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169008573 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 454169008574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008575 putative substrate translocation pore; other site 454169008576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008577 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 454169008578 S-ribosylhomocysteinase; Provisional; Region: PRK02260 454169008579 glutamate--cysteine ligase; Provisional; Region: PRK02107 454169008580 Predicted membrane protein [Function unknown]; Region: COG1238 454169008581 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 454169008582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169008583 motif II; other site 454169008584 carbon storage regulator; Provisional; Region: PRK01712 454169008585 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 454169008586 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 454169008587 motif 1; other site 454169008588 active site 454169008589 motif 2; other site 454169008590 motif 3; other site 454169008591 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 454169008592 DHHA1 domain; Region: DHHA1; pfam02272 454169008593 recombination regulator RecX; Reviewed; Region: recX; PRK00117 454169008594 recombinase A; Provisional; Region: recA; PRK09354 454169008595 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 454169008596 hexamer interface [polypeptide binding]; other site 454169008597 Walker A motif; other site 454169008598 ATP binding site [chemical binding]; other site 454169008599 Walker B motif; other site 454169008600 hypothetical protein; Validated; Region: PRK03661 454169008601 Transglycosylase SLT domain; Region: SLT_2; pfam13406 454169008602 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169008603 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169008604 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 454169008605 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 454169008606 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 454169008607 Nucleoside recognition; Region: Gate; pfam07670 454169008608 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 454169008609 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 454169008610 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 454169008611 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 454169008612 putative NAD(P) binding site [chemical binding]; other site 454169008613 active site 454169008614 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 454169008615 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 454169008616 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454169008617 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169008618 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 454169008619 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 454169008620 putative active site [active] 454169008621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 454169008622 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 454169008623 GAF domain; Region: GAF; pfam01590 454169008624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169008625 Walker A motif; other site 454169008626 ATP binding site [chemical binding]; other site 454169008627 Walker B motif; other site 454169008628 arginine finger; other site 454169008629 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 454169008630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 454169008631 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 454169008632 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 454169008633 iron binding site [ion binding]; other site 454169008634 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 454169008635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169008636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169008637 Acylphosphatase; Region: Acylphosphatase; pfam00708 454169008638 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 454169008639 HypF finger; Region: zf-HYPF; pfam07503 454169008640 HypF finger; Region: zf-HYPF; pfam07503 454169008641 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 454169008642 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 454169008643 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 454169008644 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 454169008645 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 454169008646 nickel binding site [ion binding]; other site 454169008647 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 454169008648 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 454169008649 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 454169008650 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454169008651 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 454169008652 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 454169008653 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 454169008654 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 454169008655 NADH dehydrogenase; Region: NADHdh; cl00469 454169008656 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 454169008657 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454169008658 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 454169008659 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 454169008660 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 454169008661 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 454169008662 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 454169008663 hydrogenase assembly chaperone; Provisional; Region: PRK10409 454169008664 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 454169008665 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 454169008666 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 454169008667 dimerization interface [polypeptide binding]; other site 454169008668 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 454169008669 ATP binding site [chemical binding]; other site 454169008670 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 454169008671 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 454169008672 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 454169008673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169008674 Walker A motif; other site 454169008675 ATP binding site [chemical binding]; other site 454169008676 Walker B motif; other site 454169008677 arginine finger; other site 454169008678 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454169008679 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 454169008680 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 454169008681 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 454169008682 metal binding site [ion binding]; metal-binding site 454169008683 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 454169008684 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 454169008685 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 454169008686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169008687 ABC-ATPase subunit interface; other site 454169008688 dimer interface [polypeptide binding]; other site 454169008689 putative PBP binding regions; other site 454169008690 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 454169008691 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454169008692 ABC-ATPase subunit interface; other site 454169008693 dimer interface [polypeptide binding]; other site 454169008694 putative PBP binding regions; other site 454169008695 effector protein YopJ; Provisional; Region: PRK15371 454169008696 transcriptional activator SprB; Provisional; Region: PRK15320 454169008697 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 454169008698 transcriptional regulator SirC; Provisional; Region: PRK15044 454169008699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169008700 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 454169008701 invasion protein OrgB; Provisional; Region: PRK15322 454169008702 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 454169008703 invasion protein OrgA; Provisional; Region: PRK15323 454169008704 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 454169008705 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 454169008706 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 454169008707 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 454169008708 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 454169008709 transcriptional regulator HilD; Provisional; Region: PRK15185 454169008710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169008711 invasion protein regulator; Provisional; Region: PRK12370 454169008712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169008713 DNA binding site [nucleotide binding] 454169008714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454169008715 binding surface 454169008716 TPR motif; other site 454169008717 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 454169008718 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169008719 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169008720 catalytic residue [active] 454169008721 chaperone protein SicP; Provisional; Region: PRK15329 454169008722 putative acyl carrier protein IacP; Validated; Region: PRK08172 454169008723 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 454169008724 cell invasion protein SipD; Provisional; Region: PRK15330 454169008725 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 454169008726 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 454169008727 chaperone protein SicA; Provisional; Region: PRK15331 454169008728 Tetratricopeptide repeat; Region: TPR_3; pfam07720 454169008729 Tetratricopeptide repeat; Region: TPR_3; pfam07720 454169008730 type III secretion system protein SpaS; Validated; Region: PRK08156 454169008731 type III secretion system protein SpaR; Provisional; Region: PRK15332 454169008732 type III secretion system protein SpaQ; Provisional; Region: PRK15333 454169008733 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 454169008734 type III secretion system protein SpaO; Validated; Region: PRK08158 454169008735 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 454169008736 antigen presentation protein SpaN; Provisional; Region: PRK15334 454169008737 Surface presentation of antigens protein; Region: SPAN; pfam02510 454169008738 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 454169008739 ATP synthase SpaL; Validated; Region: PRK08149 454169008740 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 454169008741 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454169008742 Walker A motif; other site 454169008743 ATP binding site [chemical binding]; other site 454169008744 Walker B motif; other site 454169008745 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 454169008746 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 454169008747 type III secretion system protein InvA; Provisional; Region: PRK15337 454169008748 type III secretion system regulator InvE; Provisional; Region: PRK15338 454169008749 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 454169008750 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 454169008751 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 454169008752 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 454169008753 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454169008754 transcriptional regulator InvF; Provisional; Region: PRK15340 454169008755 InvH outer membrane lipoprotein; Region: InvH; pfam04741 454169008756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 454169008757 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 454169008758 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454169008759 active site 454169008760 metal binding site [ion binding]; metal-binding site 454169008761 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 454169008762 MutS domain I; Region: MutS_I; pfam01624 454169008763 MutS domain II; Region: MutS_II; pfam05188 454169008764 MutS domain III; Region: MutS_III; pfam05192 454169008765 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 454169008766 Walker A/P-loop; other site 454169008767 ATP binding site [chemical binding]; other site 454169008768 Q-loop/lid; other site 454169008769 ABC transporter signature motif; other site 454169008770 Walker B; other site 454169008771 D-loop; other site 454169008772 H-loop/switch region; other site 454169008773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 454169008774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169008776 putative substrate translocation pore; other site 454169008777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169008778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169008779 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 454169008780 putative effector binding pocket; other site 454169008781 dimerization interface [polypeptide binding]; other site 454169008782 GntP family permease; Region: GntP_permease; pfam02447 454169008783 fructuronate transporter; Provisional; Region: PRK10034; cl15264 454169008784 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 454169008785 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 454169008786 putative NAD(P) binding site [chemical binding]; other site 454169008787 active site 454169008788 putative substrate binding site [chemical binding]; other site 454169008789 hypothetical protein; Provisional; Region: PRK09989 454169008790 putative aldolase; Validated; Region: PRK08130 454169008791 intersubunit interface [polypeptide binding]; other site 454169008792 active site 454169008793 Zn2+ binding site [ion binding]; other site 454169008794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 454169008795 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 454169008796 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454169008797 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169008798 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169008799 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169008800 MarR family; Region: MarR_2; cl17246 454169008801 Transcriptional regulators [Transcription]; Region: MarR; COG1846 454169008802 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 454169008803 Flavoprotein; Region: Flavoprotein; pfam02441 454169008804 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 454169008805 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 454169008806 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 454169008807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454169008808 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 454169008809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454169008810 DNA binding residues [nucleotide binding] 454169008811 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 454169008812 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169008813 Peptidase family M23; Region: Peptidase_M23; pfam01551 454169008814 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 454169008815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169008816 S-adenosylmethionine binding site [chemical binding]; other site 454169008817 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 454169008818 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 454169008819 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 454169008820 Permutation of conserved domain; other site 454169008821 active site 454169008822 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 454169008823 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 454169008824 homotrimer interaction site [polypeptide binding]; other site 454169008825 zinc binding site [ion binding]; other site 454169008826 CDP-binding sites; other site 454169008827 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 454169008828 substrate binding site; other site 454169008829 dimer interface; other site 454169008830 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 454169008831 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 454169008832 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 454169008833 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 454169008834 ligand-binding site [chemical binding]; other site 454169008835 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 454169008836 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 454169008837 CysD dimerization site [polypeptide binding]; other site 454169008838 G1 box; other site 454169008839 putative GEF interaction site [polypeptide binding]; other site 454169008840 GTP/Mg2+ binding site [chemical binding]; other site 454169008841 Switch I region; other site 454169008842 G2 box; other site 454169008843 G3 box; other site 454169008844 Switch II region; other site 454169008845 G4 box; other site 454169008846 G5 box; other site 454169008847 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 454169008848 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 454169008849 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 454169008850 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 454169008851 Active Sites [active] 454169008852 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 454169008853 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 454169008854 metal binding site [ion binding]; metal-binding site 454169008855 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 454169008856 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 454169008857 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 454169008858 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 454169008859 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 454169008860 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 454169008861 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 454169008862 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 454169008863 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 454169008864 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 454169008865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 454169008866 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 454169008867 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 454169008868 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 454169008869 Active Sites [active] 454169008870 sulfite reductase subunit beta; Provisional; Region: PRK13504 454169008871 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454169008872 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454169008873 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 454169008874 Flavodoxin; Region: Flavodoxin_1; pfam00258 454169008875 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 454169008876 FAD binding pocket [chemical binding]; other site 454169008877 FAD binding motif [chemical binding]; other site 454169008878 catalytic residues [active] 454169008879 NAD binding pocket [chemical binding]; other site 454169008880 phosphate binding motif [ion binding]; other site 454169008881 beta-alpha-beta structure motif; other site 454169008882 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 454169008883 active site 454169008884 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 454169008885 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 454169008886 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 454169008887 enolase; Provisional; Region: eno; PRK00077 454169008888 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 454169008889 dimer interface [polypeptide binding]; other site 454169008890 metal binding site [ion binding]; metal-binding site 454169008891 substrate binding pocket [chemical binding]; other site 454169008892 CTP synthetase; Validated; Region: pyrG; PRK05380 454169008893 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 454169008894 Catalytic site [active] 454169008895 active site 454169008896 UTP binding site [chemical binding]; other site 454169008897 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 454169008898 active site 454169008899 putative oxyanion hole; other site 454169008900 catalytic triad [active] 454169008901 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 454169008902 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 454169008903 homodimer interface [polypeptide binding]; other site 454169008904 metal binding site [ion binding]; metal-binding site 454169008905 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 454169008906 homodimer interface [polypeptide binding]; other site 454169008907 active site 454169008908 putative chemical substrate binding site [chemical binding]; other site 454169008909 metal binding site [ion binding]; metal-binding site 454169008910 fimbrial protein SteA; Provisional; Region: PRK15261 454169008911 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 454169008912 PapC N-terminal domain; Region: PapC_N; pfam13954 454169008913 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169008914 PapC C-terminal domain; Region: PapC_C; pfam13953 454169008915 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 454169008916 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169008917 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169008918 putative fimbrial protein SteD; Provisional; Region: PRK15275 454169008919 putative fimbrial subunit SteE; Provisional; Region: PRK15276 454169008920 fimbrial protein SteF; Provisional; Region: PRK15260 454169008921 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 454169008922 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 454169008923 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 454169008924 HD domain; Region: HD_4; pfam13328 454169008925 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 454169008926 synthetase active site [active] 454169008927 NTP binding site [chemical binding]; other site 454169008928 metal binding site [ion binding]; metal-binding site 454169008929 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 454169008930 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 454169008931 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 454169008932 TRAM domain; Region: TRAM; pfam01938 454169008933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169008934 S-adenosylmethionine binding site [chemical binding]; other site 454169008935 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 454169008936 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 454169008937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169008938 dimerization interface [polypeptide binding]; other site 454169008939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169008940 dimer interface [polypeptide binding]; other site 454169008941 phosphorylation site [posttranslational modification] 454169008942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169008943 ATP binding site [chemical binding]; other site 454169008944 Mg2+ binding site [ion binding]; other site 454169008945 G-X-G motif; other site 454169008946 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 454169008947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169008948 active site 454169008949 phosphorylation site [posttranslational modification] 454169008950 intermolecular recognition site; other site 454169008951 dimerization interface [polypeptide binding]; other site 454169008952 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454169008953 putative binding surface; other site 454169008954 active site 454169008955 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 454169008956 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 454169008957 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 454169008958 active site 454169008959 tetramer interface [polypeptide binding]; other site 454169008960 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 454169008961 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 454169008962 active site 454169008963 tetramer interface [polypeptide binding]; other site 454169008964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169008965 D-galactonate transporter; Region: 2A0114; TIGR00893 454169008966 putative substrate translocation pore; other site 454169008967 flavodoxin; Provisional; Region: PRK08105 454169008968 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 454169008969 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 454169008970 probable active site [active] 454169008971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 454169008972 SecY interacting protein Syd; Provisional; Region: PRK04968 454169008973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 454169008974 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 454169008975 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 454169008976 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 454169008977 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 454169008978 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454169008979 serine transporter; Region: stp; TIGR00814 454169008980 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 454169008981 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454169008982 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454169008983 flap endonuclease-like protein; Provisional; Region: PRK09482 454169008984 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 454169008985 active site 454169008986 metal binding site 1 [ion binding]; metal-binding site 454169008987 putative 5' ssDNA interaction site; other site 454169008988 metal binding site 3; metal-binding site 454169008989 metal binding site 2 [ion binding]; metal-binding site 454169008990 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 454169008991 putative DNA binding site [nucleotide binding]; other site 454169008992 putative metal binding site [ion binding]; other site 454169008993 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 454169008994 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 454169008995 dimer interface [polypeptide binding]; other site 454169008996 active site 454169008997 metal binding site [ion binding]; metal-binding site 454169008998 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454169008999 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454169009000 intersubunit interface [polypeptide binding]; other site 454169009001 active site 454169009002 Zn2+ binding site [ion binding]; other site 454169009003 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 454169009004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009005 putative substrate translocation pore; other site 454169009006 L-fucose isomerase; Provisional; Region: fucI; PRK10991 454169009007 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 454169009008 hexamer (dimer of trimers) interface [polypeptide binding]; other site 454169009009 trimer interface [polypeptide binding]; other site 454169009010 substrate binding site [chemical binding]; other site 454169009011 Mn binding site [ion binding]; other site 454169009012 L-fuculokinase; Provisional; Region: PRK10331 454169009013 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454169009014 nucleotide binding site [chemical binding]; other site 454169009015 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 454169009016 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 454169009017 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454169009018 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169009019 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 454169009020 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 454169009021 hypothetical protein; Provisional; Region: PRK10873 454169009022 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 454169009023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009024 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 454169009025 dimerization interface [polypeptide binding]; other site 454169009026 substrate binding pocket [chemical binding]; other site 454169009027 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454169009028 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 454169009029 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 454169009030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169009031 catalytic residue [active] 454169009032 CsdA-binding activator; Provisional; Region: PRK15019 454169009033 Predicted permeases [General function prediction only]; Region: RarD; COG2962 454169009034 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 454169009035 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 454169009036 putative ATP binding site [chemical binding]; other site 454169009037 putative substrate interface [chemical binding]; other site 454169009038 murein transglycosylase A; Provisional; Region: mltA; PRK11162 454169009039 murein hydrolase B; Provisional; Region: PRK10760; cl17906 454169009040 MltA specific insert domain; Region: MltA; pfam03562 454169009041 3D domain; Region: 3D; pfam06725 454169009042 AMIN domain; Region: AMIN; pfam11741 454169009043 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 454169009044 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 454169009045 active site 454169009046 metal binding site [ion binding]; metal-binding site 454169009047 N-acetylglutamate synthase; Validated; Region: PRK05279 454169009048 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 454169009049 putative feedback inhibition sensing region; other site 454169009050 putative nucleotide binding site [chemical binding]; other site 454169009051 putative substrate binding site [chemical binding]; other site 454169009052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169009053 Coenzyme A binding pocket [chemical binding]; other site 454169009054 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 454169009055 AAA domain; Region: AAA_30; pfam13604 454169009056 Family description; Region: UvrD_C_2; pfam13538 454169009057 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 454169009058 protease3; Provisional; Region: PRK15101 454169009059 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 454169009060 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 454169009061 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 454169009062 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 454169009063 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 454169009064 hypothetical protein; Provisional; Region: PRK10332 454169009065 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 454169009066 hypothetical protein; Provisional; Region: PRK11521 454169009067 hypothetical protein; Provisional; Region: PRK10557 454169009068 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 454169009069 hypothetical protein; Provisional; Region: PRK10506 454169009070 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 454169009071 thymidylate synthase; Reviewed; Region: thyA; PRK01827 454169009072 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 454169009073 dimerization interface [polypeptide binding]; other site 454169009074 active site 454169009075 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 454169009076 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 454169009077 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 454169009078 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 454169009079 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 454169009080 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 454169009081 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 454169009082 putative active site [active] 454169009083 Ap4A binding site [chemical binding]; other site 454169009084 nudix motif; other site 454169009085 putative metal binding site [ion binding]; other site 454169009086 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 454169009087 putative DNA-binding cleft [nucleotide binding]; other site 454169009088 putative DNA clevage site; other site 454169009089 molecular lever; other site 454169009090 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 454169009091 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454169009092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169009093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169009094 active site 454169009095 catalytic tetrad [active] 454169009096 lysophospholipid transporter LplT; Provisional; Region: PRK11195 454169009097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009098 putative substrate translocation pore; other site 454169009099 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 454169009100 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 454169009101 putative acyl-acceptor binding pocket; other site 454169009102 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 454169009103 acyl-activating enzyme (AAE) consensus motif; other site 454169009104 putative AMP binding site [chemical binding]; other site 454169009105 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 454169009106 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169009107 DNA binding site [nucleotide binding] 454169009108 domain linker motif; other site 454169009109 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454169009110 dimerization interface (closed form) [polypeptide binding]; other site 454169009111 ligand binding site [chemical binding]; other site 454169009112 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454169009113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169009114 DNA binding site [nucleotide binding] 454169009115 domain linker motif; other site 454169009116 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454169009117 dimerization interface (closed form) [polypeptide binding]; other site 454169009118 ligand binding site [chemical binding]; other site 454169009119 diaminopimelate decarboxylase; Provisional; Region: PRK11165 454169009120 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 454169009121 active site 454169009122 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169009123 substrate binding site [chemical binding]; other site 454169009124 catalytic residues [active] 454169009125 dimer interface [polypeptide binding]; other site 454169009126 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 454169009127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169009129 dimerization interface [polypeptide binding]; other site 454169009130 putative racemase; Provisional; Region: PRK10200 454169009131 aspartate racemase; Region: asp_race; TIGR00035 454169009132 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 454169009133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009134 putative substrate translocation pore; other site 454169009135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009136 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 454169009137 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 454169009138 NADP binding site [chemical binding]; other site 454169009139 homodimer interface [polypeptide binding]; other site 454169009140 active site 454169009141 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 454169009142 putative acyltransferase; Provisional; Region: PRK05790 454169009143 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 454169009144 dimer interface [polypeptide binding]; other site 454169009145 active site 454169009146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169009147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169009149 dimerization interface [polypeptide binding]; other site 454169009150 Predicted membrane protein [Function unknown]; Region: COG4125 454169009151 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 454169009152 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 454169009153 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454169009154 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 454169009155 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 454169009156 putative metal binding site [ion binding]; other site 454169009157 putative homodimer interface [polypeptide binding]; other site 454169009158 putative homotetramer interface [polypeptide binding]; other site 454169009159 putative homodimer-homodimer interface [polypeptide binding]; other site 454169009160 putative allosteric switch controlling residues; other site 454169009161 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 454169009162 transcriptional activator SprB; Provisional; Region: PRK15320 454169009163 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 454169009164 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 454169009165 Fimbrial protein; Region: Fimbrial; pfam00419 454169009166 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 454169009167 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169009168 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169009169 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 454169009170 PapC N-terminal domain; Region: PapC_N; pfam13954 454169009171 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169009172 PapC C-terminal domain; Region: PapC_C; pfam13953 454169009173 fimbrial protein StdA; Provisional; Region: PRK15210 454169009174 hypothetical protein; Provisional; Region: PRK10316 454169009175 YfdX protein; Region: YfdX; pfam10938 454169009176 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 454169009177 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 454169009178 tetramer interface [polypeptide binding]; other site 454169009179 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 454169009180 active site 454169009181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 454169009182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454169009183 NAD(P) binding site [chemical binding]; other site 454169009184 active site 454169009185 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 454169009186 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454169009187 substrate binding site [chemical binding]; other site 454169009188 hexamer interface [polypeptide binding]; other site 454169009189 metal binding site [ion binding]; metal-binding site 454169009190 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454169009191 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 454169009192 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 454169009193 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169009194 active site 454169009195 phosphorylation site [posttranslational modification] 454169009196 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169009197 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169009198 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169009199 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 454169009200 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454169009201 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 454169009202 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454169009203 active site 454169009204 P-loop; other site 454169009205 phosphorylation site [posttranslational modification] 454169009206 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169009207 active site 454169009208 phosphorylation site [posttranslational modification] 454169009209 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 454169009210 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 454169009211 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 454169009212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169009213 dimerization interface [polypeptide binding]; other site 454169009214 putative DNA binding site [nucleotide binding]; other site 454169009215 putative Zn2+ binding site [ion binding]; other site 454169009216 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 454169009217 active site 454169009218 Int/Topo IB signature motif; other site 454169009219 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454169009220 Peptidase family M23; Region: Peptidase_M23; pfam01551 454169009221 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 454169009222 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 454169009223 active site 454169009224 metal binding site [ion binding]; metal-binding site 454169009225 nudix motif; other site 454169009226 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 454169009227 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 454169009228 dimer interface [polypeptide binding]; other site 454169009229 putative anticodon binding site; other site 454169009230 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 454169009231 motif 1; other site 454169009232 active site 454169009233 motif 2; other site 454169009234 motif 3; other site 454169009235 This domain is found in peptide chain release factors; Region: PCRF; smart00937 454169009236 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 454169009237 RF-1 domain; Region: RF-1; pfam00472 454169009238 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 454169009239 DHH family; Region: DHH; pfam01368 454169009240 DHHA1 domain; Region: DHHA1; pfam02272 454169009241 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 454169009242 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 454169009243 dimerization domain [polypeptide binding]; other site 454169009244 dimer interface [polypeptide binding]; other site 454169009245 catalytic residues [active] 454169009246 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 454169009247 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 454169009248 active site 454169009249 Int/Topo IB signature motif; other site 454169009250 flavodoxin FldB; Provisional; Region: PRK12359 454169009251 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 454169009252 hypothetical protein; Provisional; Region: PRK10878 454169009253 putative global regulator; Reviewed; Region: PRK09559 454169009254 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 454169009255 hemolysin; Provisional; Region: PRK15087 454169009256 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 454169009257 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 454169009258 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 454169009259 beta-galactosidase; Region: BGL; TIGR03356 454169009260 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 454169009261 glycine dehydrogenase; Provisional; Region: PRK05367 454169009262 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 454169009263 tetramer interface [polypeptide binding]; other site 454169009264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169009265 catalytic residue [active] 454169009266 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 454169009267 tetramer interface [polypeptide binding]; other site 454169009268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169009269 catalytic residue [active] 454169009270 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 454169009271 lipoyl attachment site [posttranslational modification]; other site 454169009272 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 454169009273 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 454169009274 oxidoreductase; Provisional; Region: PRK08013 454169009275 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 454169009276 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 454169009277 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 454169009278 proline aminopeptidase P II; Provisional; Region: PRK10879 454169009279 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 454169009280 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 454169009281 active site 454169009282 hypothetical protein; Reviewed; Region: PRK01736 454169009283 Z-ring-associated protein; Provisional; Region: PRK10972 454169009284 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 454169009285 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 454169009286 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 454169009287 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 454169009288 ligand binding site [chemical binding]; other site 454169009289 NAD binding site [chemical binding]; other site 454169009290 tetramer interface [polypeptide binding]; other site 454169009291 catalytic site [active] 454169009292 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 454169009293 L-serine binding site [chemical binding]; other site 454169009294 ACT domain interface; other site 454169009295 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 454169009296 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454169009297 active site 454169009298 dimer interface [polypeptide binding]; other site 454169009299 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 454169009300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009301 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 454169009302 putative dimerization interface [polypeptide binding]; other site 454169009303 Uncharacterized conserved protein [Function unknown]; Region: COG2968 454169009304 oxidative stress defense protein; Provisional; Region: PRK11087 454169009305 arginine exporter protein; Provisional; Region: PRK09304 454169009306 mechanosensitive channel MscS; Provisional; Region: PRK10334 454169009307 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169009308 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 454169009309 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 454169009310 active site 454169009311 intersubunit interface [polypeptide binding]; other site 454169009312 zinc binding site [ion binding]; other site 454169009313 Na+ binding site [ion binding]; other site 454169009314 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 454169009315 Phosphoglycerate kinase; Region: PGK; pfam00162 454169009316 substrate binding site [chemical binding]; other site 454169009317 hinge regions; other site 454169009318 ADP binding site [chemical binding]; other site 454169009319 catalytic site [active] 454169009320 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 454169009321 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 454169009322 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 454169009323 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 454169009324 trimer interface [polypeptide binding]; other site 454169009325 putative Zn binding site [ion binding]; other site 454169009326 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 454169009327 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 454169009328 Walker A/P-loop; other site 454169009329 ATP binding site [chemical binding]; other site 454169009330 ABC transporter; Region: ABC_tran; pfam00005 454169009331 Q-loop/lid; other site 454169009332 ABC transporter signature motif; other site 454169009333 Walker B; other site 454169009334 D-loop; other site 454169009335 H-loop/switch region; other site 454169009336 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 454169009337 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 454169009338 Walker A/P-loop; other site 454169009339 ATP binding site [chemical binding]; other site 454169009340 Q-loop/lid; other site 454169009341 ABC transporter signature motif; other site 454169009342 Walker B; other site 454169009343 D-loop; other site 454169009344 H-loop/switch region; other site 454169009345 transketolase; Reviewed; Region: PRK12753 454169009346 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 454169009347 TPP-binding site [chemical binding]; other site 454169009348 dimer interface [polypeptide binding]; other site 454169009349 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454169009350 PYR/PP interface [polypeptide binding]; other site 454169009351 dimer interface [polypeptide binding]; other site 454169009352 TPP binding site [chemical binding]; other site 454169009353 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454169009354 Transposase domain (DUF772); Region: DUF772; pfam05598 454169009355 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169009356 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169009357 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 454169009358 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 454169009359 agmatinase; Region: agmatinase; TIGR01230 454169009360 oligomer interface [polypeptide binding]; other site 454169009361 putative active site [active] 454169009362 Mn binding site [ion binding]; other site 454169009363 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 454169009364 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454169009365 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 454169009366 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454169009367 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 454169009368 putative NAD(P) binding site [chemical binding]; other site 454169009369 catalytic Zn binding site [ion binding]; other site 454169009370 structural Zn binding site [ion binding]; other site 454169009371 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 454169009372 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454169009373 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454169009374 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454169009375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169009376 DNA-binding site [nucleotide binding]; DNA binding site 454169009377 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454169009378 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 454169009379 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 454169009380 dimer interface [polypeptide binding]; other site 454169009381 active site 454169009382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169009383 catalytic residues [active] 454169009384 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 454169009385 Virulence promoting factor; Region: YqgB; pfam11036 454169009386 S-adenosylmethionine synthetase; Validated; Region: PRK05250 454169009387 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 454169009388 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 454169009389 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 454169009390 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 454169009391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009392 putative substrate translocation pore; other site 454169009393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009394 hypothetical protein; Provisional; Region: PRK04860 454169009395 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 454169009396 DNA-specific endonuclease I; Provisional; Region: PRK15137 454169009397 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 454169009398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 454169009399 RNA methyltransferase, RsmE family; Region: TIGR00046 454169009400 glutathione synthetase; Provisional; Region: PRK05246 454169009401 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 454169009402 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 454169009403 hypothetical protein; Validated; Region: PRK00228 454169009404 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 454169009405 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 454169009406 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454169009407 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 454169009408 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 454169009409 Walker A motif; other site 454169009410 ATP binding site [chemical binding]; other site 454169009411 Walker B motif; other site 454169009412 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 454169009413 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169009414 catalytic residue [active] 454169009415 YGGT family; Region: YGGT; pfam02325 454169009416 YGGT family; Region: YGGT; pfam02325 454169009417 hypothetical protein; Validated; Region: PRK05090 454169009418 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 454169009419 active site 454169009420 dimerization interface [polypeptide binding]; other site 454169009421 HemN family oxidoreductase; Provisional; Region: PRK05660 454169009422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169009423 FeS/SAM binding site; other site 454169009424 HemN C-terminal domain; Region: HemN_C; pfam06969 454169009425 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 454169009426 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 454169009427 homodimer interface [polypeptide binding]; other site 454169009428 active site 454169009429 hypothetical protein; Provisional; Region: PRK10626 454169009430 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 454169009431 hypothetical protein; Provisional; Region: PRK11702 454169009432 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 454169009433 adenine DNA glycosylase; Provisional; Region: PRK10880 454169009434 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 454169009435 minor groove reading motif; other site 454169009436 helix-hairpin-helix signature motif; other site 454169009437 substrate binding pocket [chemical binding]; other site 454169009438 active site 454169009439 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 454169009440 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 454169009441 DNA binding and oxoG recognition site [nucleotide binding] 454169009442 oxidative damage protection protein; Provisional; Region: PRK05408 454169009443 murein transglycosylase C; Provisional; Region: mltC; PRK11671 454169009444 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 454169009445 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169009446 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169009447 catalytic residue [active] 454169009448 nucleoside transporter; Region: 2A0110; TIGR00889 454169009449 ornithine decarboxylase; Provisional; Region: PRK13578 454169009450 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454169009451 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454169009452 homodimer interface [polypeptide binding]; other site 454169009453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169009454 catalytic residue [active] 454169009455 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454169009456 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 454169009457 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 454169009458 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 454169009459 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 454169009460 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 454169009461 putative active site [active] 454169009462 putative catalytic site [active] 454169009463 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 454169009464 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 454169009465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009466 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 454169009467 putative dimerization interface [polypeptide binding]; other site 454169009468 putative substrate binding pocket [chemical binding]; other site 454169009469 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454169009470 Sulfatase; Region: Sulfatase; pfam00884 454169009471 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454169009472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169009473 FeS/SAM binding site; other site 454169009474 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454169009475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454169009476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169009477 DNA binding residues [nucleotide binding] 454169009478 dimerization interface [polypeptide binding]; other site 454169009479 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 454169009480 Amino acid permease; Region: AA_permease_2; pfam13520 454169009481 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 454169009482 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 454169009483 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 454169009484 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 454169009485 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 454169009486 NAD(P) binding site [chemical binding]; other site 454169009487 catalytic residues [active] 454169009488 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 454169009489 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 454169009490 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 454169009491 active site 454169009492 catalytic site [active] 454169009493 Zn binding site [ion binding]; other site 454169009494 tetramer interface [polypeptide binding]; other site 454169009495 Predicted amidohydrolase [General function prediction only]; Region: COG0388 454169009496 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 454169009497 putative active site [active] 454169009498 catalytic triad [active] 454169009499 putative dimer interface [polypeptide binding]; other site 454169009500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169009501 D-galactonate transporter; Region: 2A0114; TIGR00893 454169009502 putative substrate translocation pore; other site 454169009503 mannonate dehydratase; Provisional; Region: PRK03906 454169009504 mannonate dehydratase; Region: uxuA; TIGR00695 454169009505 D-mannonate oxidoreductase; Provisional; Region: PRK15037 454169009506 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454169009507 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454169009508 Glucuronate isomerase; Region: UxaC; pfam02614 454169009509 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 454169009510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169009511 dimer interface [polypeptide binding]; other site 454169009512 putative CheW interface [polypeptide binding]; other site 454169009513 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 454169009514 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 454169009515 CHAP domain; Region: CHAP; pfam05257 454169009516 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 454169009517 putative S-transferase; Provisional; Region: PRK11752 454169009518 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 454169009519 C-terminal domain interface [polypeptide binding]; other site 454169009520 GSH binding site (G-site) [chemical binding]; other site 454169009521 dimer interface [polypeptide binding]; other site 454169009522 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 454169009523 dimer interface [polypeptide binding]; other site 454169009524 N-terminal domain interface [polypeptide binding]; other site 454169009525 active site 454169009526 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454169009527 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 454169009528 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 454169009529 putative ligand binding residues [chemical binding]; other site 454169009530 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 454169009531 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 454169009532 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 454169009533 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 454169009534 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 454169009535 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 454169009536 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 454169009537 putative substrate-binding site; other site 454169009538 nickel binding site [ion binding]; other site 454169009539 hydrogenase 2 large subunit; Provisional; Region: PRK10467 454169009540 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 454169009541 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 454169009542 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 454169009543 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 454169009544 4Fe-4S binding domain; Region: Fer4_6; pfam12837 454169009545 hydrogenase 2 small subunit; Provisional; Region: PRK10468 454169009546 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 454169009547 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 454169009548 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 454169009549 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 454169009550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169009551 dimerization interface [polypeptide binding]; other site 454169009552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169009553 dimer interface [polypeptide binding]; other site 454169009554 putative CheW interface [polypeptide binding]; other site 454169009555 hypothetical protein; Provisional; Region: PRK05208 454169009556 oxidoreductase; Provisional; Region: PRK07985 454169009557 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 454169009558 NAD binding site [chemical binding]; other site 454169009559 metal binding site [ion binding]; metal-binding site 454169009560 active site 454169009561 biopolymer transport protein ExbD; Provisional; Region: PRK11267 454169009562 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 454169009563 biopolymer transport protein ExbB; Provisional; Region: PRK10414 454169009564 cystathionine beta-lyase; Provisional; Region: PRK08114 454169009565 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 454169009566 homodimer interface [polypeptide binding]; other site 454169009567 substrate-cofactor binding pocket; other site 454169009568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169009569 catalytic residue [active] 454169009570 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454169009571 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 454169009572 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 454169009573 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 454169009574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169009575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169009576 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 454169009577 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 454169009578 dimer interface [polypeptide binding]; other site 454169009579 active site 454169009580 metal binding site [ion binding]; metal-binding site 454169009581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454169009582 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454169009583 active site 454169009584 catalytic tetrad [active] 454169009585 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 454169009586 nucleotide binding site/active site [active] 454169009587 catalytic residue [active] 454169009588 hypothetical protein; Provisional; Region: PRK01254 454169009589 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 454169009590 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 454169009591 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 454169009592 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 454169009593 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 454169009594 DctM-like transporters; Region: DctM; pfam06808 454169009595 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 454169009596 FtsI repressor; Provisional; Region: PRK10883 454169009597 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 454169009598 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 454169009599 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 454169009600 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 454169009601 putative acyl-acceptor binding pocket; other site 454169009602 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 454169009603 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 454169009604 CAP-like domain; other site 454169009605 active site 454169009606 primary dimer interface [polypeptide binding]; other site 454169009607 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454169009608 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169009609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169009610 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 454169009611 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 454169009612 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 454169009613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169009614 active site 454169009615 phosphorylation site [posttranslational modification] 454169009616 intermolecular recognition site; other site 454169009617 dimerization interface [polypeptide binding]; other site 454169009618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169009619 DNA binding site [nucleotide binding] 454169009620 sensor protein QseC; Provisional; Region: PRK10337 454169009621 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 454169009622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169009623 dimer interface [polypeptide binding]; other site 454169009624 phosphorylation site [posttranslational modification] 454169009625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169009626 ATP binding site [chemical binding]; other site 454169009627 Mg2+ binding site [ion binding]; other site 454169009628 G-X-G motif; other site 454169009629 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 454169009630 Uncharacterized conserved protein [Function unknown]; Region: COG1359 454169009631 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 454169009632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169009633 ATP binding site [chemical binding]; other site 454169009634 Mg2+ binding site [ion binding]; other site 454169009635 G-X-G motif; other site 454169009636 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 454169009637 anchoring element; other site 454169009638 dimer interface [polypeptide binding]; other site 454169009639 ATP binding site [chemical binding]; other site 454169009640 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 454169009641 active site 454169009642 metal binding site [ion binding]; metal-binding site 454169009643 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 454169009644 esterase YqiA; Provisional; Region: PRK11071 454169009645 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 454169009646 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454169009647 active site 454169009648 metal binding site [ion binding]; metal-binding site 454169009649 hexamer interface [polypeptide binding]; other site 454169009650 putative dehydrogenase; Provisional; Region: PRK11039 454169009651 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 454169009652 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 454169009653 dimer interface [polypeptide binding]; other site 454169009654 ADP-ribose binding site [chemical binding]; other site 454169009655 active site 454169009656 nudix motif; other site 454169009657 metal binding site [ion binding]; metal-binding site 454169009658 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 454169009659 hypothetical protein; Provisional; Region: PRK11653 454169009660 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 454169009661 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 454169009662 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 454169009663 putative active site [active] 454169009664 metal binding site [ion binding]; metal-binding site 454169009665 zinc transporter ZupT; Provisional; Region: PRK04201 454169009666 ZIP Zinc transporter; Region: Zip; pfam02535 454169009667 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 454169009668 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454169009669 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 454169009670 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454169009671 catalytic residues [active] 454169009672 hinge region; other site 454169009673 alpha helical domain; other site 454169009674 putative disulfide oxidoreductase; Provisional; Region: PRK04307 454169009675 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 454169009676 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 454169009677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 454169009678 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 454169009679 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 454169009680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 454169009681 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 454169009682 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 454169009683 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 454169009684 putative ribose interaction site [chemical binding]; other site 454169009685 putative ADP binding site [chemical binding]; other site 454169009686 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 454169009687 active site 454169009688 nucleotide binding site [chemical binding]; other site 454169009689 HIGH motif; other site 454169009690 KMSKS motif; other site 454169009691 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 454169009692 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 454169009693 metal binding triad; other site 454169009694 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 454169009695 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 454169009696 metal binding triad; other site 454169009697 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 454169009698 Uncharacterized conserved protein [Function unknown]; Region: COG3025 454169009699 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 454169009700 putative active site [active] 454169009701 putative metal binding residues [ion binding]; other site 454169009702 signature motif; other site 454169009703 putative triphosphate binding site [ion binding]; other site 454169009704 CHAD domain; Region: CHAD; cl10506 454169009705 SH3 domain-containing protein; Provisional; Region: PRK10884 454169009706 Bacterial SH3 domain homologues; Region: SH3b; smart00287 454169009707 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 454169009708 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 454169009709 active site 454169009710 NTP binding site [chemical binding]; other site 454169009711 metal binding triad [ion binding]; metal-binding site 454169009712 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 454169009713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454169009714 Zn2+ binding site [ion binding]; other site 454169009715 Mg2+ binding site [ion binding]; other site 454169009716 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 454169009717 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 454169009718 homooctamer interface [polypeptide binding]; other site 454169009719 active site 454169009720 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 454169009721 UGMP family protein; Validated; Region: PRK09604 454169009722 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 454169009723 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 454169009724 DNA primase; Validated; Region: dnaG; PRK05667 454169009725 CHC2 zinc finger; Region: zf-CHC2; pfam01807 454169009726 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 454169009727 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 454169009728 active site 454169009729 metal binding site [ion binding]; metal-binding site 454169009730 interdomain interaction site; other site 454169009731 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 454169009732 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 454169009733 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 454169009734 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 454169009735 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 454169009736 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 454169009737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454169009738 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 454169009739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454169009740 DNA binding residues [nucleotide binding] 454169009741 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 454169009742 active site 454169009743 SUMO-1 interface [polypeptide binding]; other site 454169009744 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 454169009745 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454169009746 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 454169009747 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 454169009748 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 454169009749 Baseplate J-like protein; Region: Baseplate_J; cl01294 454169009750 Baseplate J-like protein; Region: Baseplate_J; pfam04865 454169009751 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 454169009752 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 454169009753 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 454169009754 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 454169009755 Phage holin family 2; Region: Phage_holin_2; pfam04550 454169009756 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 454169009757 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 454169009758 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 454169009759 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 454169009760 terminase endonuclease subunit; Provisional; Region: M; PHA02537 454169009761 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 454169009762 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 454169009763 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 454169009764 terminase ATPase subunit; Provisional; Region: P; PHA02535 454169009765 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 454169009766 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 454169009767 Phage-related protein [Function unknown]; Region: COG4695; cl01923 454169009768 Phage portal protein; Region: Phage_portal; pfam04860 454169009769 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 454169009770 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 454169009771 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 454169009772 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 454169009773 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 454169009774 active site 454169009775 catalytic site [active] 454169009776 substrate binding site [chemical binding]; other site 454169009777 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 454169009778 threonine ammonia-lyase, medium form; Region: ilvA_1Cterm; TIGR01127 454169009779 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 454169009780 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 454169009781 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 454169009782 Short C-terminal domain; Region: SHOCT; pfam09851 454169009783 integrase; Provisional; Region: int; PHA02601 454169009784 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 454169009785 dimer interface [polypeptide binding]; other site 454169009786 active site 454169009787 catalytic residues [active] 454169009788 Int/Topo IB signature motif; other site 454169009789 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 454169009790 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 454169009791 FAD binding pocket [chemical binding]; other site 454169009792 FAD binding motif [chemical binding]; other site 454169009793 phosphate binding motif [ion binding]; other site 454169009794 NAD binding pocket [chemical binding]; other site 454169009795 Predicted transcriptional regulators [Transcription]; Region: COG1695 454169009796 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 454169009797 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 454169009798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169009799 dimerization interface [polypeptide binding]; other site 454169009800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 454169009801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169009802 dimer interface [polypeptide binding]; other site 454169009803 putative CheW interface [polypeptide binding]; other site 454169009804 PAS fold; Region: PAS_3; pfam08447 454169009805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169009806 putative active site [active] 454169009807 heme pocket [chemical binding]; other site 454169009808 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 454169009809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169009810 dimer interface [polypeptide binding]; other site 454169009811 putative CheW interface [polypeptide binding]; other site 454169009812 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 454169009813 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454169009814 inhibitor-cofactor binding pocket; inhibition site 454169009815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169009816 catalytic residue [active] 454169009817 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 454169009818 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 454169009819 active site 454169009820 FMN binding site [chemical binding]; other site 454169009821 2,4-decadienoyl-CoA binding site; other site 454169009822 catalytic residue [active] 454169009823 4Fe-4S cluster binding site [ion binding]; other site 454169009824 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 454169009825 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169009826 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 454169009827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169009828 S-adenosylmethionine binding site [chemical binding]; other site 454169009829 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 454169009830 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454169009831 putative active site [active] 454169009832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454169009833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454169009834 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 454169009835 serine/threonine transporter SstT; Provisional; Region: PRK13628 454169009836 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454169009837 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454169009838 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 454169009839 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 454169009840 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 454169009841 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 454169009842 Predicted membrane protein [Function unknown]; Region: COG5393 454169009843 YqjK-like protein; Region: YqjK; pfam13997 454169009844 Predicted membrane protein [Function unknown]; Region: COG2259 454169009845 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 454169009846 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 454169009847 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 454169009848 putative dimer interface [polypeptide binding]; other site 454169009849 N-terminal domain interface [polypeptide binding]; other site 454169009850 putative substrate binding pocket (H-site) [chemical binding]; other site 454169009851 Predicted membrane protein [Function unknown]; Region: COG3152 454169009852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009853 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 454169009854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169009855 dimerization interface [polypeptide binding]; other site 454169009856 Pirin-related protein [General function prediction only]; Region: COG1741 454169009857 Pirin; Region: Pirin; pfam02678 454169009858 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 454169009859 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454169009860 serine transporter; Region: stp; TIGR00814 454169009861 L-serine dehydratase TdcG; Provisional; Region: PRK15040 454169009862 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454169009863 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454169009864 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 454169009865 Pyruvate formate lyase 1; Region: PFL1; cd01678 454169009866 coenzyme A binding site [chemical binding]; other site 454169009867 active site 454169009868 catalytic residues [active] 454169009869 glycine loop; other site 454169009870 propionate/acetate kinase; Provisional; Region: PRK12379 454169009871 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 454169009872 threonine/serine transporter TdcC; Provisional; Region: PRK13629 454169009873 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454169009874 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 454169009875 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 454169009876 tetramer interface [polypeptide binding]; other site 454169009877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169009878 catalytic residue [active] 454169009879 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 454169009880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169009881 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 454169009882 putative substrate binding pocket [chemical binding]; other site 454169009883 putative dimerization interface [polypeptide binding]; other site 454169009884 glycerate kinase I; Provisional; Region: PRK10342 454169009885 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 454169009886 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454169009887 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 454169009888 galactarate dehydratase; Region: galactar-dH20; TIGR03248 454169009889 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 454169009890 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 454169009891 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 454169009892 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 454169009893 intersubunit interface [polypeptide binding]; other site 454169009894 active site 454169009895 zinc binding site [ion binding]; other site 454169009896 Na+ binding site [ion binding]; other site 454169009897 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 454169009898 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169009899 active site 454169009900 phosphorylation site [posttranslational modification] 454169009901 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454169009902 active site 454169009903 P-loop; other site 454169009904 phosphorylation site [posttranslational modification] 454169009905 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454169009906 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 454169009907 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 454169009908 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 454169009909 putative NAD(P) binding site [chemical binding]; other site 454169009910 catalytic Zn binding site [ion binding]; other site 454169009911 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169009912 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169009913 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169009914 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 454169009915 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 454169009916 putative SAM binding site [chemical binding]; other site 454169009917 putative homodimer interface [polypeptide binding]; other site 454169009918 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 454169009919 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 454169009920 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 454169009921 putative ligand binding site [chemical binding]; other site 454169009922 TIGR00252 family protein; Region: TIGR00252 454169009923 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 454169009924 dimer interface [polypeptide binding]; other site 454169009925 active site 454169009926 outer membrane lipoprotein; Provisional; Region: PRK11023 454169009927 BON domain; Region: BON; pfam04972 454169009928 BON domain; Region: BON; pfam04972 454169009929 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 454169009930 NADH(P)-binding; Region: NAD_binding_10; pfam13460 454169009931 NAD binding site [chemical binding]; other site 454169009932 active site 454169009933 intracellular protease, PfpI family; Region: PfpI; TIGR01382 454169009934 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 454169009935 proposed catalytic triad [active] 454169009936 conserved cys residue [active] 454169009937 hypothetical protein; Provisional; Region: PRK03467 454169009938 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 454169009939 GIY-YIG motif/motif A; other site 454169009940 putative active site [active] 454169009941 putative metal binding site [ion binding]; other site 454169009942 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 454169009943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169009944 Coenzyme A binding pocket [chemical binding]; other site 454169009945 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 454169009946 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 454169009947 Peptidase family U32; Region: Peptidase_U32; pfam01136 454169009948 putative protease; Provisional; Region: PRK15447 454169009949 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 454169009950 hypothetical protein; Provisional; Region: PRK10508 454169009951 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 454169009952 tryptophan permease; Provisional; Region: PRK10483 454169009953 aromatic amino acid transport protein; Region: araaP; TIGR00837 454169009954 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454169009955 DEAD-like helicases superfamily; Region: DEXDc; smart00487 454169009956 ATP binding site [chemical binding]; other site 454169009957 Mg++ binding site [ion binding]; other site 454169009958 motif III; other site 454169009959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169009960 nucleotide binding region [chemical binding]; other site 454169009961 ATP-binding site [chemical binding]; other site 454169009962 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 454169009963 putative RNA binding site [nucleotide binding]; other site 454169009964 lipoprotein NlpI; Provisional; Region: PRK11189 454169009965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454169009966 binding surface 454169009967 TPR motif; other site 454169009968 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 454169009969 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 454169009970 RNase E interface [polypeptide binding]; other site 454169009971 trimer interface [polypeptide binding]; other site 454169009972 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 454169009973 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 454169009974 RNase E interface [polypeptide binding]; other site 454169009975 trimer interface [polypeptide binding]; other site 454169009976 active site 454169009977 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 454169009978 putative nucleic acid binding region [nucleotide binding]; other site 454169009979 G-X-X-G motif; other site 454169009980 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 454169009981 RNA binding site [nucleotide binding]; other site 454169009982 domain interface; other site 454169009983 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 454169009984 16S/18S rRNA binding site [nucleotide binding]; other site 454169009985 S13e-L30e interaction site [polypeptide binding]; other site 454169009986 25S rRNA binding site [nucleotide binding]; other site 454169009987 Ribosomal S15 leader 454169009988 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 454169009989 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 454169009990 RNA binding site [nucleotide binding]; other site 454169009991 active site 454169009992 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 454169009993 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 454169009994 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 454169009995 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 454169009996 translation initiation factor IF-2; Region: IF-2; TIGR00487 454169009997 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 454169009998 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 454169009999 G1 box; other site 454169010000 putative GEF interaction site [polypeptide binding]; other site 454169010001 GTP/Mg2+ binding site [chemical binding]; other site 454169010002 Switch I region; other site 454169010003 G2 box; other site 454169010004 G3 box; other site 454169010005 Switch II region; other site 454169010006 G4 box; other site 454169010007 G5 box; other site 454169010008 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 454169010009 Translation-initiation factor 2; Region: IF-2; pfam11987 454169010010 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 454169010011 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 454169010012 NusA N-terminal domain; Region: NusA_N; pfam08529 454169010013 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 454169010014 RNA binding site [nucleotide binding]; other site 454169010015 homodimer interface [polypeptide binding]; other site 454169010016 NusA-like KH domain; Region: KH_5; pfam13184 454169010017 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 454169010018 G-X-X-G motif; other site 454169010019 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 454169010020 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 454169010021 ribosome maturation protein RimP; Reviewed; Region: PRK00092 454169010022 Sm and related proteins; Region: Sm_like; cl00259 454169010023 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 454169010024 putative oligomer interface [polypeptide binding]; other site 454169010025 putative RNA binding site [nucleotide binding]; other site 454169010026 argininosuccinate synthase; Validated; Region: PRK05370 454169010027 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 454169010028 Preprotein translocase SecG subunit; Region: SecG; pfam03840 454169010029 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 454169010030 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 454169010031 active site 454169010032 substrate binding site [chemical binding]; other site 454169010033 metal binding site [ion binding]; metal-binding site 454169010034 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 454169010035 dihydropteroate synthase; Region: DHPS; TIGR01496 454169010036 substrate binding pocket [chemical binding]; other site 454169010037 dimer interface [polypeptide binding]; other site 454169010038 inhibitor binding site; inhibition site 454169010039 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 454169010040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169010041 Walker A motif; other site 454169010042 ATP binding site [chemical binding]; other site 454169010043 Walker B motif; other site 454169010044 arginine finger; other site 454169010045 Peptidase family M41; Region: Peptidase_M41; pfam01434 454169010046 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 454169010047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169010048 S-adenosylmethionine binding site [chemical binding]; other site 454169010049 RNA-binding protein YhbY; Provisional; Region: PRK10343 454169010050 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 454169010051 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 454169010052 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 454169010053 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 454169010054 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 454169010055 GTPase CgtA; Reviewed; Region: obgE; PRK12298 454169010056 GTP1/OBG; Region: GTP1_OBG; pfam01018 454169010057 Obg GTPase; Region: Obg; cd01898 454169010058 G1 box; other site 454169010059 GTP/Mg2+ binding site [chemical binding]; other site 454169010060 Switch I region; other site 454169010061 G2 box; other site 454169010062 G3 box; other site 454169010063 Switch II region; other site 454169010064 G4 box; other site 454169010065 G5 box; other site 454169010066 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454169010067 EamA-like transporter family; Region: EamA; pfam00892 454169010068 EamA-like transporter family; Region: EamA; pfam00892 454169010069 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 454169010070 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 454169010071 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 454169010072 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 454169010073 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 454169010074 substrate binding pocket [chemical binding]; other site 454169010075 chain length determination region; other site 454169010076 substrate-Mg2+ binding site; other site 454169010077 catalytic residues [active] 454169010078 aspartate-rich region 1; other site 454169010079 active site lid residues [active] 454169010080 aspartate-rich region 2; other site 454169010081 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 454169010082 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 454169010083 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 454169010084 hinge; other site 454169010085 active site 454169010086 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 454169010087 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 454169010088 anti sigma factor interaction site; other site 454169010089 regulatory phosphorylation site [posttranslational modification]; other site 454169010090 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 454169010091 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 454169010092 mce related protein; Region: MCE; pfam02470 454169010093 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 454169010094 conserved hypothetical integral membrane protein; Region: TIGR00056 454169010095 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 454169010096 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 454169010097 Walker A/P-loop; other site 454169010098 ATP binding site [chemical binding]; other site 454169010099 Q-loop/lid; other site 454169010100 ABC transporter signature motif; other site 454169010101 Walker B; other site 454169010102 D-loop; other site 454169010103 H-loop/switch region; other site 454169010104 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 454169010105 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 454169010106 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 454169010107 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 454169010108 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 454169010109 putative active site [active] 454169010110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 454169010111 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 454169010112 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 454169010113 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 454169010114 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 454169010115 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 454169010116 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 454169010117 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 454169010118 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 454169010119 Walker A/P-loop; other site 454169010120 ATP binding site [chemical binding]; other site 454169010121 Q-loop/lid; other site 454169010122 ABC transporter signature motif; other site 454169010123 Walker B; other site 454169010124 D-loop; other site 454169010125 H-loop/switch region; other site 454169010126 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 454169010127 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 454169010128 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 454169010129 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 454169010130 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 454169010131 30S subunit binding site; other site 454169010132 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169010133 active site 454169010134 phosphorylation site [posttranslational modification] 454169010135 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 454169010136 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454169010137 dimerization domain swap beta strand [polypeptide binding]; other site 454169010138 regulatory protein interface [polypeptide binding]; other site 454169010139 active site 454169010140 regulatory phosphorylation site [posttranslational modification]; other site 454169010141 hypothetical protein; Provisional; Region: PRK10345 454169010142 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 454169010143 Transglycosylase; Region: Transgly; cl17702 454169010144 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 454169010145 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 454169010146 conserved cys residue [active] 454169010147 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 454169010148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169010149 putative active site [active] 454169010150 heme pocket [chemical binding]; other site 454169010151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169010152 dimer interface [polypeptide binding]; other site 454169010153 phosphorylation site [posttranslational modification] 454169010154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169010155 ATP binding site [chemical binding]; other site 454169010156 Mg2+ binding site [ion binding]; other site 454169010157 G-X-G motif; other site 454169010158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169010159 active site 454169010160 phosphorylation site [posttranslational modification] 454169010161 intermolecular recognition site; other site 454169010162 dimerization interface [polypeptide binding]; other site 454169010163 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454169010164 putative binding surface; other site 454169010165 active site 454169010166 radical SAM protein, TIGR01212 family; Region: TIGR01212 454169010167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169010168 FeS/SAM binding site; other site 454169010169 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 454169010170 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 454169010171 active site 454169010172 dimer interface [polypeptide binding]; other site 454169010173 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 454169010174 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 454169010175 active site 454169010176 FMN binding site [chemical binding]; other site 454169010177 substrate binding site [chemical binding]; other site 454169010178 3Fe-4S cluster binding site [ion binding]; other site 454169010179 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 454169010180 domain interface; other site 454169010181 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 454169010182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169010183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169010184 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 454169010185 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 454169010186 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 454169010187 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 454169010188 Na binding site [ion binding]; other site 454169010189 putative substrate binding site [chemical binding]; other site 454169010190 cytosine deaminase; Provisional; Region: PRK09230 454169010191 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 454169010192 active site 454169010193 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454169010194 N-acetylmannosamine kinase; Provisional; Region: PRK05082 454169010195 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169010196 nucleotide binding site [chemical binding]; other site 454169010197 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 454169010198 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 454169010199 putative active site cavity [active] 454169010200 putative sialic acid transporter; Provisional; Region: PRK03893 454169010201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169010202 putative substrate translocation pore; other site 454169010203 N-acetylneuraminate lyase; Provisional; Region: PRK04147 454169010204 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 454169010205 inhibitor site; inhibition site 454169010206 active site 454169010207 dimer interface [polypeptide binding]; other site 454169010208 catalytic residue [active] 454169010209 transcriptional regulator NanR; Provisional; Region: PRK03837 454169010210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169010211 DNA-binding site [nucleotide binding]; DNA binding site 454169010212 FCD domain; Region: FCD; pfam07729 454169010213 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 454169010214 stringent starvation protein A; Provisional; Region: sspA; PRK09481 454169010215 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 454169010216 C-terminal domain interface [polypeptide binding]; other site 454169010217 putative GSH binding site (G-site) [chemical binding]; other site 454169010218 dimer interface [polypeptide binding]; other site 454169010219 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 454169010220 dimer interface [polypeptide binding]; other site 454169010221 N-terminal domain interface [polypeptide binding]; other site 454169010222 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 454169010223 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 454169010224 23S rRNA interface [nucleotide binding]; other site 454169010225 L3 interface [polypeptide binding]; other site 454169010226 Predicted ATPase [General function prediction only]; Region: COG1485 454169010227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 454169010228 hypothetical protein; Provisional; Region: PRK11677 454169010229 serine endoprotease; Provisional; Region: PRK10139 454169010230 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 454169010231 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454169010232 protein binding site [polypeptide binding]; other site 454169010233 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454169010234 serine endoprotease; Provisional; Region: PRK10898 454169010235 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 454169010236 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454169010237 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 454169010238 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 454169010239 oxaloacetate decarboxylase; Provisional; Region: PRK14040 454169010240 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 454169010241 active site 454169010242 catalytic residues [active] 454169010243 metal binding site [ion binding]; metal-binding site 454169010244 homodimer binding site [polypeptide binding]; other site 454169010245 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454169010246 carboxyltransferase (CT) interaction site; other site 454169010247 biotinylation site [posttranslational modification]; other site 454169010248 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 454169010249 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 454169010250 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 454169010251 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 454169010252 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454169010253 transmembrane helices; other site 454169010254 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454169010255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169010256 DNA-binding site [nucleotide binding]; DNA binding site 454169010257 FCD domain; Region: FCD; pfam07729 454169010258 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454169010259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169010260 DNA-binding site [nucleotide binding]; DNA binding site 454169010261 malate dehydrogenase; Provisional; Region: PRK05086 454169010262 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 454169010263 NAD binding site [chemical binding]; other site 454169010264 dimerization interface [polypeptide binding]; other site 454169010265 Substrate binding site [chemical binding]; other site 454169010266 arginine repressor; Provisional; Region: PRK05066 454169010267 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 454169010268 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 454169010269 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169010270 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169010271 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 454169010272 RNAase interaction site [polypeptide binding]; other site 454169010273 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 454169010274 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454169010275 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 454169010276 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169010277 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169010278 efflux system membrane protein; Provisional; Region: PRK11594 454169010279 transcriptional regulator; Provisional; Region: PRK10632 454169010280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169010281 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 454169010282 putative effector binding pocket; other site 454169010283 dimerization interface [polypeptide binding]; other site 454169010284 protease TldD; Provisional; Region: tldD; PRK10735 454169010285 hypothetical protein; Provisional; Region: PRK10899 454169010286 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 454169010287 ribonuclease G; Provisional; Region: PRK11712 454169010288 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 454169010289 homodimer interface [polypeptide binding]; other site 454169010290 oligonucleotide binding site [chemical binding]; other site 454169010291 Maf-like protein; Region: Maf; pfam02545 454169010292 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 454169010293 active site 454169010294 dimer interface [polypeptide binding]; other site 454169010295 rod shape-determining protein MreD; Provisional; Region: PRK11060 454169010296 rod shape-determining protein MreC; Region: mreC; TIGR00219 454169010297 rod shape-determining protein MreC; Region: MreC; pfam04085 454169010298 rod shape-determining protein MreB; Provisional; Region: PRK13927 454169010299 MreB and similar proteins; Region: MreB_like; cd10225 454169010300 nucleotide binding site [chemical binding]; other site 454169010301 Mg binding site [ion binding]; other site 454169010302 putative protofilament interaction site [polypeptide binding]; other site 454169010303 RodZ interaction site [polypeptide binding]; other site 454169010304 regulatory protein CsrD; Provisional; Region: PRK11059 454169010305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169010306 metal binding site [ion binding]; metal-binding site 454169010307 active site 454169010308 I-site; other site 454169010309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169010310 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 454169010311 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 454169010312 NADP binding site [chemical binding]; other site 454169010313 dimer interface [polypeptide binding]; other site 454169010314 TMAO/DMSO reductase; Reviewed; Region: PRK05363 454169010315 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 454169010316 Moco binding site; other site 454169010317 metal coordination site [ion binding]; other site 454169010318 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 454169010319 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 454169010320 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454169010321 carboxyltransferase (CT) interaction site; other site 454169010322 biotinylation site [posttranslational modification]; other site 454169010323 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 454169010324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 454169010325 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 454169010326 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 454169010327 hypothetical protein; Provisional; Region: PRK10633 454169010328 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 454169010329 Na binding site [ion binding]; other site 454169010330 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 454169010331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 454169010332 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 454169010333 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 454169010334 FMN binding site [chemical binding]; other site 454169010335 active site 454169010336 catalytic residues [active] 454169010337 substrate binding site [chemical binding]; other site 454169010338 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 454169010339 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 454169010340 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 454169010341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169010342 DNA methylase; Region: N6_N4_Mtase; pfam01555 454169010343 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 454169010344 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 454169010345 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 454169010346 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 454169010347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169010348 metal binding site [ion binding]; metal-binding site 454169010349 active site 454169010350 I-site; other site 454169010351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169010352 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 454169010353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169010354 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 454169010355 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 454169010356 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169010357 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169010358 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 454169010359 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 454169010360 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 454169010361 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 454169010362 trimer interface [polypeptide binding]; other site 454169010363 putative metal binding site [ion binding]; other site 454169010364 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 454169010365 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 454169010366 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 454169010367 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 454169010368 shikimate binding site; other site 454169010369 NAD(P) binding site [chemical binding]; other site 454169010370 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 454169010371 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454169010372 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 454169010373 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454169010374 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454169010375 hypothetical protein; Validated; Region: PRK03430 454169010376 hypothetical protein; Provisional; Region: PRK10736 454169010377 DNA protecting protein DprA; Region: dprA; TIGR00732 454169010378 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 454169010379 active site 454169010380 catalytic residues [active] 454169010381 metal binding site [ion binding]; metal-binding site 454169010382 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 454169010383 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 454169010384 putative active site [active] 454169010385 substrate binding site [chemical binding]; other site 454169010386 putative cosubstrate binding site; other site 454169010387 catalytic site [active] 454169010388 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 454169010389 substrate binding site [chemical binding]; other site 454169010390 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 454169010391 putative RNA binding site [nucleotide binding]; other site 454169010392 16S rRNA methyltransferase B; Provisional; Region: PRK10901 454169010393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169010394 S-adenosylmethionine binding site [chemical binding]; other site 454169010395 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 454169010396 TrkA-N domain; Region: TrkA_N; pfam02254 454169010397 TrkA-C domain; Region: TrkA_C; pfam02080 454169010398 TrkA-N domain; Region: TrkA_N; pfam02254 454169010399 TrkA-C domain; Region: TrkA_C; pfam02080 454169010400 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 454169010401 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 454169010402 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 454169010403 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 454169010404 DNA binding residues [nucleotide binding] 454169010405 dimer interface [polypeptide binding]; other site 454169010406 metal binding site [ion binding]; metal-binding site 454169010407 hypothetical protein; Provisional; Region: PRK10203 454169010408 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 454169010409 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 454169010410 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 454169010411 alphaNTD homodimer interface [polypeptide binding]; other site 454169010412 alphaNTD - beta interaction site [polypeptide binding]; other site 454169010413 alphaNTD - beta' interaction site [polypeptide binding]; other site 454169010414 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 454169010415 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 454169010416 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 454169010417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169010418 RNA binding surface [nucleotide binding]; other site 454169010419 30S ribosomal protein S11; Validated; Region: PRK05309 454169010420 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 454169010421 30S ribosomal protein S13; Region: bact_S13; TIGR03631 454169010422 Alpha operon ribosome binding site 454169010423 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 454169010424 SecY translocase; Region: SecY; pfam00344 454169010425 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 454169010426 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 454169010427 23S rRNA binding site [nucleotide binding]; other site 454169010428 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 454169010429 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 454169010430 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 454169010431 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 454169010432 23S rRNA interface [nucleotide binding]; other site 454169010433 5S rRNA interface [nucleotide binding]; other site 454169010434 L27 interface [polypeptide binding]; other site 454169010435 L5 interface [polypeptide binding]; other site 454169010436 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 454169010437 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 454169010438 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 454169010439 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 454169010440 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 454169010441 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 454169010442 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 454169010443 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 454169010444 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 454169010445 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 454169010446 RNA binding site [nucleotide binding]; other site 454169010447 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 454169010448 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 454169010449 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 454169010450 23S rRNA interface [nucleotide binding]; other site 454169010451 putative translocon interaction site; other site 454169010452 signal recognition particle (SRP54) interaction site; other site 454169010453 L23 interface [polypeptide binding]; other site 454169010454 trigger factor interaction site; other site 454169010455 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 454169010456 23S rRNA interface [nucleotide binding]; other site 454169010457 5S rRNA interface [nucleotide binding]; other site 454169010458 putative antibiotic binding site [chemical binding]; other site 454169010459 L25 interface [polypeptide binding]; other site 454169010460 L27 interface [polypeptide binding]; other site 454169010461 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 454169010462 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 454169010463 G-X-X-G motif; other site 454169010464 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 454169010465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 454169010466 protein-rRNA interface [nucleotide binding]; other site 454169010467 putative translocon binding site; other site 454169010468 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 454169010469 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 454169010470 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 454169010471 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 454169010472 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 454169010473 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 454169010474 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 454169010475 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 454169010476 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 454169010477 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 454169010478 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 454169010479 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 454169010480 heme binding site [chemical binding]; other site 454169010481 ferroxidase pore; other site 454169010482 ferroxidase diiron center [ion binding]; other site 454169010483 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 454169010484 elongation factor Tu; Reviewed; Region: PRK00049 454169010485 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 454169010486 G1 box; other site 454169010487 GEF interaction site [polypeptide binding]; other site 454169010488 GTP/Mg2+ binding site [chemical binding]; other site 454169010489 Switch I region; other site 454169010490 G2 box; other site 454169010491 G3 box; other site 454169010492 Switch II region; other site 454169010493 G4 box; other site 454169010494 G5 box; other site 454169010495 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 454169010496 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 454169010497 Antibiotic Binding Site [chemical binding]; other site 454169010498 elongation factor G; Reviewed; Region: PRK00007 454169010499 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 454169010500 G1 box; other site 454169010501 putative GEF interaction site [polypeptide binding]; other site 454169010502 GTP/Mg2+ binding site [chemical binding]; other site 454169010503 Switch I region; other site 454169010504 G2 box; other site 454169010505 G3 box; other site 454169010506 Switch II region; other site 454169010507 G4 box; other site 454169010508 G5 box; other site 454169010509 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 454169010510 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 454169010511 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 454169010512 30S ribosomal protein S7; Validated; Region: PRK05302 454169010513 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 454169010514 S17 interaction site [polypeptide binding]; other site 454169010515 S8 interaction site; other site 454169010516 16S rRNA interaction site [nucleotide binding]; other site 454169010517 streptomycin interaction site [chemical binding]; other site 454169010518 23S rRNA interaction site [nucleotide binding]; other site 454169010519 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 454169010520 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 454169010521 sulfur relay protein TusC; Validated; Region: PRK00211 454169010522 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 454169010523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 454169010524 YheO-like PAS domain; Region: PAS_6; pfam08348 454169010525 HTH domain; Region: HTH_22; pfam13309 454169010526 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 454169010527 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 454169010528 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454169010529 phi X174 lysis protein; Provisional; Region: PRK02793 454169010530 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 454169010531 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454169010532 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 454169010533 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 454169010534 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 454169010535 TrkA-N domain; Region: TrkA_N; pfam02254 454169010536 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 454169010537 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 454169010538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169010539 Walker A/P-loop; other site 454169010540 ATP binding site [chemical binding]; other site 454169010541 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169010542 ABC transporter signature motif; other site 454169010543 Walker B; other site 454169010544 D-loop; other site 454169010545 ABC transporter; Region: ABC_tran_2; pfam12848 454169010546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169010547 putative monooxygenase; Provisional; Region: PRK11118 454169010548 putative hydrolase; Provisional; Region: PRK10985 454169010549 hypothetical protein; Provisional; Region: PRK04966 454169010550 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 454169010551 active site 454169010552 hypothetical protein; Provisional; Region: PRK10738 454169010553 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 454169010554 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 454169010555 ligand binding site [chemical binding]; other site 454169010556 flexible hinge region; other site 454169010557 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 454169010558 putative switch regulator; other site 454169010559 non-specific DNA interactions [nucleotide binding]; other site 454169010560 DNA binding site [nucleotide binding] 454169010561 sequence specific DNA binding site [nucleotide binding]; other site 454169010562 putative cAMP binding site [chemical binding]; other site 454169010563 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 454169010564 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 454169010565 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454169010566 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 454169010567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454169010568 inhibitor-cofactor binding pocket; inhibition site 454169010569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169010570 catalytic residue [active] 454169010571 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 454169010572 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 454169010573 glutamine binding [chemical binding]; other site 454169010574 catalytic triad [active] 454169010575 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 454169010576 cell filamentation protein Fic; Provisional; Region: PRK10347 454169010577 hypothetical protein; Provisional; Region: PRK10204 454169010578 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 454169010579 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 454169010580 substrate binding site [chemical binding]; other site 454169010581 putative transporter; Provisional; Region: PRK03699 454169010582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169010583 putative substrate translocation pore; other site 454169010584 nitrite reductase subunit NirD; Provisional; Region: PRK14989 454169010585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169010586 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 454169010587 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 454169010588 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454169010589 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 454169010590 nitrite transporter NirC; Provisional; Region: PRK11562 454169010591 siroheme synthase; Provisional; Region: cysG; PRK10637 454169010592 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 454169010593 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 454169010594 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 454169010595 active site 454169010596 SAM binding site [chemical binding]; other site 454169010597 homodimer interface [polypeptide binding]; other site 454169010598 Autotransporter beta-domain; Region: Autotransporter; pfam03797 454169010599 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 454169010600 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 454169010601 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 454169010602 active site 454169010603 HIGH motif; other site 454169010604 dimer interface [polypeptide binding]; other site 454169010605 KMSKS motif; other site 454169010606 phosphoglycolate phosphatase; Provisional; Region: PRK13222 454169010607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169010608 motif II; other site 454169010609 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454169010610 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 454169010611 substrate binding site [chemical binding]; other site 454169010612 hexamer interface [polypeptide binding]; other site 454169010613 metal binding site [ion binding]; metal-binding site 454169010614 DNA adenine methylase; Provisional; Region: PRK10904 454169010615 cell division protein DamX; Validated; Region: PRK10905 454169010616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 454169010617 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 454169010618 active site 454169010619 dimer interface [polypeptide binding]; other site 454169010620 metal binding site [ion binding]; metal-binding site 454169010621 shikimate kinase; Reviewed; Region: aroK; PRK00131 454169010622 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 454169010623 ADP binding site [chemical binding]; other site 454169010624 magnesium binding site [ion binding]; other site 454169010625 putative shikimate binding site; other site 454169010626 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 454169010627 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454169010628 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 454169010629 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 454169010630 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 454169010631 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 454169010632 Transglycosylase; Region: Transgly; pfam00912 454169010633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 454169010634 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 454169010635 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 454169010636 ADP-ribose binding site [chemical binding]; other site 454169010637 dimer interface [polypeptide binding]; other site 454169010638 active site 454169010639 nudix motif; other site 454169010640 metal binding site [ion binding]; metal-binding site 454169010641 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 454169010642 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 454169010643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169010644 motif II; other site 454169010645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169010646 RNA binding surface [nucleotide binding]; other site 454169010647 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 454169010648 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 454169010649 dimerization interface [polypeptide binding]; other site 454169010650 domain crossover interface; other site 454169010651 redox-dependent activation switch; other site 454169010652 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 454169010653 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 454169010654 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 454169010655 active site 454169010656 substrate-binding site [chemical binding]; other site 454169010657 metal-binding site [ion binding] 454169010658 ATP binding site [chemical binding]; other site 454169010659 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 454169010660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169010661 dimerization interface [polypeptide binding]; other site 454169010662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169010663 dimer interface [polypeptide binding]; other site 454169010664 phosphorylation site [posttranslational modification] 454169010665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169010666 ATP binding site [chemical binding]; other site 454169010667 G-X-G motif; other site 454169010668 osmolarity response regulator; Provisional; Region: ompR; PRK09468 454169010669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169010670 active site 454169010671 phosphorylation site [posttranslational modification] 454169010672 intermolecular recognition site; other site 454169010673 dimerization interface [polypeptide binding]; other site 454169010674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169010675 DNA binding site [nucleotide binding] 454169010676 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 454169010677 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 454169010678 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 454169010679 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 454169010680 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 454169010681 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 454169010682 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 454169010683 RNA binding site [nucleotide binding]; other site 454169010684 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 454169010685 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 454169010686 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 454169010687 G1 box; other site 454169010688 GTP/Mg2+ binding site [chemical binding]; other site 454169010689 Switch I region; other site 454169010690 G2 box; other site 454169010691 G3 box; other site 454169010692 Switch II region; other site 454169010693 G4 box; other site 454169010694 G5 box; other site 454169010695 Nucleoside recognition; Region: Gate; pfam07670 454169010696 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 454169010697 Nucleoside recognition; Region: Gate; pfam07670 454169010698 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 454169010699 hypothetical protein; Provisional; Region: PRK09956 454169010700 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454169010701 carboxylesterase BioH; Provisional; Region: PRK10349 454169010702 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 454169010703 DNA utilization protein GntX; Provisional; Region: PRK11595 454169010704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169010705 active site 454169010706 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 454169010707 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 454169010708 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 454169010709 high-affinity gluconate transporter; Provisional; Region: PRK14984 454169010710 gluconate transporter; Region: gntP; TIGR00791 454169010711 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 454169010712 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 454169010713 maltodextrin phosphorylase; Provisional; Region: PRK14985 454169010714 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 454169010715 homodimer interface [polypeptide binding]; other site 454169010716 active site pocket [active] 454169010717 transcriptional regulator MalT; Provisional; Region: PRK04841 454169010718 AAA ATPase domain; Region: AAA_16; pfam13191 454169010719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169010720 DNA binding residues [nucleotide binding] 454169010721 dimerization interface [polypeptide binding]; other site 454169010722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 454169010723 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 454169010724 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 454169010725 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 454169010726 putative active site [active] 454169010727 adenylation catalytic residue [active] 454169010728 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 454169010729 hypothetical protein; Reviewed; Region: PRK09588 454169010730 TROVE domain; Region: TROVE; pfam05731 454169010731 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 454169010732 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 454169010733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169010734 Walker A motif; other site 454169010735 ATP binding site [chemical binding]; other site 454169010736 Walker B motif; other site 454169010737 arginine finger; other site 454169010738 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 454169010739 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454169010740 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169010741 intramembrane serine protease GlpG; Provisional; Region: PRK10907 454169010742 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 454169010743 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 454169010744 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 454169010745 active site residue [active] 454169010746 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 454169010747 hypothetical protein; Provisional; Region: PRK09781 454169010748 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 454169010749 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 454169010750 dimer interface [polypeptide binding]; other site 454169010751 active site 454169010752 metal binding site [ion binding]; metal-binding site 454169010753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169010754 D-galactonate transporter; Region: 2A0114; TIGR00893 454169010755 putative substrate translocation pore; other site 454169010756 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 454169010757 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 454169010758 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 454169010759 inhibitor site; inhibition site 454169010760 active site 454169010761 dimer interface [polypeptide binding]; other site 454169010762 catalytic residue [active] 454169010763 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454169010764 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454169010765 Bacterial transcriptional regulator; Region: IclR; pfam01614 454169010766 glycogen phosphorylase; Provisional; Region: PRK14986 454169010767 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 454169010768 homodimer interface [polypeptide binding]; other site 454169010769 active site pocket [active] 454169010770 glycogen synthase; Provisional; Region: glgA; PRK00654 454169010771 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 454169010772 ADP-binding pocket [chemical binding]; other site 454169010773 homodimer interface [polypeptide binding]; other site 454169010774 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 454169010775 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 454169010776 ligand binding site; other site 454169010777 oligomer interface; other site 454169010778 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 454169010779 dimer interface [polypeptide binding]; other site 454169010780 N-terminal domain interface [polypeptide binding]; other site 454169010781 sulfate 1 binding site; other site 454169010782 glycogen debranching enzyme; Provisional; Region: PRK03705 454169010783 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 454169010784 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 454169010785 active site 454169010786 catalytic site [active] 454169010787 glycogen branching enzyme; Provisional; Region: PRK05402 454169010788 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 454169010789 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 454169010790 active site 454169010791 catalytic site [active] 454169010792 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 454169010793 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 454169010794 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 454169010795 low affinity gluconate transporter; Provisional; Region: PRK10472 454169010796 gluconate transporter; Region: gntP; TIGR00791 454169010797 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 454169010798 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 454169010799 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169010800 DNA binding site [nucleotide binding] 454169010801 domain linker motif; other site 454169010802 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454169010803 putative ligand binding site [chemical binding]; other site 454169010804 putative dimerization interface [polypeptide binding]; other site 454169010805 Pirin-related protein [General function prediction only]; Region: COG1741 454169010806 Pirin; Region: Pirin; pfam02678 454169010807 putative oxidoreductase; Provisional; Region: PRK10206 454169010808 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454169010809 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454169010810 putative acetyltransferase YhhY; Provisional; Region: PRK10140 454169010811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169010812 Coenzyme A binding pocket [chemical binding]; other site 454169010813 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169010814 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454169010815 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169010816 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454169010817 substrate binding site [chemical binding]; other site 454169010818 dimer interface [polypeptide binding]; other site 454169010819 ATP binding site [chemical binding]; other site 454169010820 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 454169010821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 454169010822 Protein of unknown function, DUF606; Region: DUF606; pfam04657 454169010823 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 454169010824 active site 454169010825 substrate binding pocket [chemical binding]; other site 454169010826 homodimer interaction site [polypeptide binding]; other site 454169010827 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 454169010828 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 454169010829 hypothetical protein; Provisional; Region: PRK10350 454169010830 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 454169010831 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 454169010832 putative active site [active] 454169010833 catalytic site [active] 454169010834 putative metal binding site [ion binding]; other site 454169010835 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 454169010836 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 454169010837 Walker A/P-loop; other site 454169010838 ATP binding site [chemical binding]; other site 454169010839 Q-loop/lid; other site 454169010840 ABC transporter signature motif; other site 454169010841 Walker B; other site 454169010842 D-loop; other site 454169010843 H-loop/switch region; other site 454169010844 TOBE domain; Region: TOBE_2; pfam08402 454169010845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 454169010846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169010847 dimer interface [polypeptide binding]; other site 454169010848 conserved gate region; other site 454169010849 ABC-ATPase subunit interface; other site 454169010850 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 454169010851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169010852 dimer interface [polypeptide binding]; other site 454169010853 conserved gate region; other site 454169010854 putative PBP binding loops; other site 454169010855 ABC-ATPase subunit interface; other site 454169010856 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 454169010857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 454169010858 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 454169010859 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 454169010860 Walker A/P-loop; other site 454169010861 ATP binding site [chemical binding]; other site 454169010862 Q-loop/lid; other site 454169010863 ABC transporter signature motif; other site 454169010864 Walker B; other site 454169010865 D-loop; other site 454169010866 H-loop/switch region; other site 454169010867 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 454169010868 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 454169010869 Walker A/P-loop; other site 454169010870 ATP binding site [chemical binding]; other site 454169010871 Q-loop/lid; other site 454169010872 ABC transporter signature motif; other site 454169010873 Walker B; other site 454169010874 D-loop; other site 454169010875 H-loop/switch region; other site 454169010876 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 454169010877 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 454169010878 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 454169010879 TM-ABC transporter signature motif; other site 454169010880 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454169010881 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 454169010882 TM-ABC transporter signature motif; other site 454169010883 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 454169010884 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 454169010885 dimerization interface [polypeptide binding]; other site 454169010886 ligand binding site [chemical binding]; other site 454169010887 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 454169010888 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 454169010889 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 454169010890 dimerization interface [polypeptide binding]; other site 454169010891 ligand binding site [chemical binding]; other site 454169010892 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 454169010893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454169010894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454169010895 DNA binding residues [nucleotide binding] 454169010896 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 454169010897 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 454169010898 cell division protein FtsE; Provisional; Region: PRK10908 454169010899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169010900 Walker A/P-loop; other site 454169010901 ATP binding site [chemical binding]; other site 454169010902 Q-loop/lid; other site 454169010903 ABC transporter signature motif; other site 454169010904 Walker B; other site 454169010905 D-loop; other site 454169010906 H-loop/switch region; other site 454169010907 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 454169010908 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 454169010909 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 454169010910 P loop; other site 454169010911 GTP binding site [chemical binding]; other site 454169010912 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 454169010913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169010914 S-adenosylmethionine binding site [chemical binding]; other site 454169010915 hypothetical protein; Provisional; Region: PRK10910 454169010916 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 454169010917 Predicted membrane protein [Function unknown]; Region: COG3714 454169010918 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 454169010919 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454169010920 metal-binding site [ion binding] 454169010921 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454169010922 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 454169010923 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454169010924 dimer interface [polypeptide binding]; other site 454169010925 ligand binding site [chemical binding]; other site 454169010926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169010927 dimerization interface [polypeptide binding]; other site 454169010928 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169010929 dimer interface [polypeptide binding]; other site 454169010930 putative CheW interface [polypeptide binding]; other site 454169010931 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 454169010932 CPxP motif; other site 454169010933 hypothetical protein; Provisional; Region: PRK11212 454169010934 hypothetical protein; Provisional; Region: PRK11615 454169010935 major facilitator superfamily transporter; Provisional; Region: PRK05122 454169010936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169010937 putative substrate translocation pore; other site 454169010938 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 454169010939 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454169010940 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 454169010941 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 454169010942 nickel responsive regulator; Provisional; Region: PRK02967 454169010943 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 454169010944 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454169010945 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 454169010946 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454169010947 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 454169010948 Walker A/P-loop; other site 454169010949 ATP binding site [chemical binding]; other site 454169010950 Q-loop/lid; other site 454169010951 ABC transporter signature motif; other site 454169010952 Walker B; other site 454169010953 D-loop; other site 454169010954 H-loop/switch region; other site 454169010955 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454169010956 Walker A/P-loop; other site 454169010957 ATP binding site [chemical binding]; other site 454169010958 Q-loop/lid; other site 454169010959 ABC transporter signature motif; other site 454169010960 Walker B; other site 454169010961 D-loop; other site 454169010962 H-loop/switch region; other site 454169010963 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454169010964 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 454169010965 HlyD family secretion protein; Region: HlyD; pfam00529 454169010966 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169010967 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169010968 Predicted flavoproteins [General function prediction only]; Region: COG2081 454169010969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169010970 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 454169010971 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 454169010972 universal stress protein UspB; Provisional; Region: PRK04960 454169010973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454169010974 Ligand Binding Site [chemical binding]; other site 454169010975 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 454169010976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169010977 putative substrate translocation pore; other site 454169010978 POT family; Region: PTR2; pfam00854 454169010979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169010980 S-adenosylmethionine binding site [chemical binding]; other site 454169010981 oligopeptidase A; Provisional; Region: PRK10911 454169010982 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 454169010983 active site 454169010984 Zn binding site [ion binding]; other site 454169010985 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 454169010986 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454169010987 active site 454169010988 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 454169010989 glutathione reductase; Validated; Region: PRK06116 454169010990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454169010991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169010992 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454169010993 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 454169010994 active site 454169010995 homodimer interface [polypeptide binding]; other site 454169010996 homotetramer interface [polypeptide binding]; other site 454169010997 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 454169010998 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 454169010999 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 454169011000 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169011001 substrate binding site [chemical binding]; other site 454169011002 ATP binding site [chemical binding]; other site 454169011003 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 454169011004 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 454169011005 putative active site [active] 454169011006 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454169011007 dimer interface [polypeptide binding]; other site 454169011008 active site 454169011009 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454169011010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169011011 DNA-binding site [nucleotide binding]; DNA binding site 454169011012 UTRA domain; Region: UTRA; pfam07702 454169011013 trehalase; Provisional; Region: treF; PRK13270 454169011014 Trehalase; Region: Trehalase; pfam01204 454169011015 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 454169011016 catalytic residue [active] 454169011017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454169011018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 454169011019 active site 454169011020 phosphorylation site [posttranslational modification] 454169011021 dimerization interface [polypeptide binding]; other site 454169011022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169011023 DNA binding residues [nucleotide binding] 454169011024 dimerization interface [polypeptide binding]; other site 454169011025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169011026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169011027 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 454169011028 putative effector binding pocket; other site 454169011029 putative dimerization interface [polypeptide binding]; other site 454169011030 inner membrane protein YhjD; Region: TIGR00766 454169011031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011032 metabolite-proton symporter; Region: 2A0106; TIGR00883 454169011033 putative substrate translocation pore; other site 454169011034 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 454169011035 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 454169011036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169011037 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169011038 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 454169011039 substrate binding site [chemical binding]; other site 454169011040 ATP binding site [chemical binding]; other site 454169011041 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 454169011042 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 454169011043 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 454169011044 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454169011045 putative diguanylate cyclase; Provisional; Region: PRK13561 454169011046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169011047 metal binding site [ion binding]; metal-binding site 454169011048 active site 454169011049 I-site; other site 454169011050 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169011051 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 454169011052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454169011053 TPR motif; other site 454169011054 binding surface 454169011055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454169011056 binding surface 454169011057 TPR motif; other site 454169011058 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 454169011059 endo-1,4-D-glucanase; Provisional; Region: PRK11097 454169011060 cellulose synthase regulator protein; Provisional; Region: PRK11114 454169011061 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 454169011062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169011063 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 454169011064 DXD motif; other site 454169011065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169011066 PilZ domain; Region: PilZ; pfam07238 454169011067 cell division protein; Provisional; Region: PRK10037 454169011068 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 454169011069 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 454169011070 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 454169011071 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 454169011072 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 454169011073 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 454169011074 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 454169011075 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454169011076 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 454169011077 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 454169011078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169011079 Walker A/P-loop; other site 454169011080 ATP binding site [chemical binding]; other site 454169011081 Q-loop/lid; other site 454169011082 ABC transporter signature motif; other site 454169011083 Walker B; other site 454169011084 D-loop; other site 454169011085 H-loop/switch region; other site 454169011086 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 454169011087 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 454169011088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454169011089 Walker A/P-loop; other site 454169011090 ATP binding site [chemical binding]; other site 454169011091 Q-loop/lid; other site 454169011092 ABC transporter signature motif; other site 454169011093 Walker B; other site 454169011094 D-loop; other site 454169011095 H-loop/switch region; other site 454169011096 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 454169011097 dipeptide transporter; Provisional; Region: PRK10913 454169011098 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454169011099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169011100 dimer interface [polypeptide binding]; other site 454169011101 conserved gate region; other site 454169011102 putative PBP binding loops; other site 454169011103 ABC-ATPase subunit interface; other site 454169011104 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 454169011105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169011106 dimer interface [polypeptide binding]; other site 454169011107 conserved gate region; other site 454169011108 putative PBP binding loops; other site 454169011109 ABC-ATPase subunit interface; other site 454169011110 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 454169011111 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 454169011112 peptide binding site [polypeptide binding]; other site 454169011113 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 454169011114 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 454169011115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454169011116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169011117 DNA binding site [nucleotide binding] 454169011118 domain linker motif; other site 454169011119 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 454169011120 putative dimerization interface [polypeptide binding]; other site 454169011121 putative ligand binding site [chemical binding]; other site 454169011122 phosphoethanolamine transferase; Provisional; Region: PRK11560 454169011123 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 454169011124 Sulfatase; Region: Sulfatase; pfam00884 454169011125 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 454169011126 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 454169011127 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 454169011128 PapC N-terminal domain; Region: PapC_N; pfam13954 454169011129 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169011130 PapC C-terminal domain; Region: PapC_C; pfam13953 454169011131 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 454169011132 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169011133 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169011134 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 454169011135 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 454169011136 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 454169011137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169011138 Coenzyme A binding pocket [chemical binding]; other site 454169011139 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 454169011140 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 454169011141 molybdopterin cofactor binding site [chemical binding]; other site 454169011142 substrate binding site [chemical binding]; other site 454169011143 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 454169011144 molybdopterin cofactor binding site; other site 454169011145 putative outer membrane lipoprotein; Provisional; Region: PRK10510 454169011146 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454169011147 ligand binding site [chemical binding]; other site 454169011148 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 454169011149 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 454169011150 dimerization interface [polypeptide binding]; other site 454169011151 ligand binding site [chemical binding]; other site 454169011152 NADP binding site [chemical binding]; other site 454169011153 catalytic site [active] 454169011154 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 454169011155 Predicted transcriptional regulator [Transcription]; Region: COG2944 454169011156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169011157 salt bridge; other site 454169011158 non-specific DNA binding site [nucleotide binding]; other site 454169011159 sequence-specific DNA binding site [nucleotide binding]; other site 454169011160 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454169011161 DNA-binding site [nucleotide binding]; DNA binding site 454169011162 RNA-binding motif; other site 454169011163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 454169011164 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 454169011165 DALR anticodon binding domain; Region: DALR_1; pfam05746 454169011166 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 454169011167 dimer interface [polypeptide binding]; other site 454169011168 motif 1; other site 454169011169 active site 454169011170 motif 2; other site 454169011171 motif 3; other site 454169011172 YsaB-like lipoprotein; Region: YsaB; pfam13983 454169011173 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 454169011174 Acyltransferase family; Region: Acyl_transf_3; pfam01757 454169011175 Predicted membrane protein [Function unknown]; Region: COG4682 454169011176 yiaA/B two helix domain; Region: YiaAB; cl01759 454169011177 yiaA/B two helix domain; Region: YiaAB; cl01759 454169011178 xylulokinase; Provisional; Region: PRK15027 454169011179 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 454169011180 N- and C-terminal domain interface [polypeptide binding]; other site 454169011181 active site 454169011182 MgATP binding site [chemical binding]; other site 454169011183 catalytic site [active] 454169011184 metal binding site [ion binding]; metal-binding site 454169011185 xylulose binding site [chemical binding]; other site 454169011186 homodimer interface [polypeptide binding]; other site 454169011187 xylose isomerase; Provisional; Region: PRK05474 454169011188 xylose isomerase; Region: xylose_isom_A; TIGR02630 454169011189 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 454169011190 putative dimerization interface [polypeptide binding]; other site 454169011191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454169011192 putative ligand binding site [chemical binding]; other site 454169011193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169011194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169011195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169011196 hypothetical protein; Provisional; Region: PRK10356 454169011197 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 454169011198 alpha-amylase; Reviewed; Region: malS; PRK09505 454169011199 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 454169011200 active site 454169011201 catalytic site [active] 454169011202 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 454169011203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169011204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169011205 homodimer interface [polypeptide binding]; other site 454169011206 catalytic residue [active] 454169011207 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 454169011208 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454169011209 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454169011210 Bacterial transcriptional regulator; Region: IclR; pfam01614 454169011211 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 454169011212 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454169011213 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 454169011214 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 454169011215 DctM-like transporters; Region: DctM; pfam06808 454169011216 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 454169011217 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 454169011218 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 454169011219 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 454169011220 putative N- and C-terminal domain interface [polypeptide binding]; other site 454169011221 putative active site [active] 454169011222 MgATP binding site [chemical binding]; other site 454169011223 catalytic site [active] 454169011224 metal binding site [ion binding]; metal-binding site 454169011225 putative xylulose binding site [chemical binding]; other site 454169011226 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 454169011227 active site 454169011228 dimer interface [polypeptide binding]; other site 454169011229 magnesium binding site [ion binding]; other site 454169011230 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 454169011231 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 454169011232 AP (apurinic/apyrimidinic) site pocket; other site 454169011233 DNA interaction; other site 454169011234 Metal-binding active site; metal-binding site 454169011235 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454169011236 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454169011237 intersubunit interface [polypeptide binding]; other site 454169011238 active site 454169011239 Zn2+ binding site [ion binding]; other site 454169011240 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454169011241 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 454169011242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169011243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 454169011244 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 454169011245 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 454169011246 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 454169011247 NAD(P) binding site [chemical binding]; other site 454169011248 catalytic residues [active] 454169011249 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 454169011250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454169011251 nucleotide binding site [chemical binding]; other site 454169011252 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 454169011253 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 454169011254 G1 box; other site 454169011255 putative GEF interaction site [polypeptide binding]; other site 454169011256 GTP/Mg2+ binding site [chemical binding]; other site 454169011257 Switch I region; other site 454169011258 G2 box; other site 454169011259 G3 box; other site 454169011260 Switch II region; other site 454169011261 G4 box; other site 454169011262 G5 box; other site 454169011263 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 454169011264 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 454169011265 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 454169011266 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 454169011267 selenocysteine synthase; Provisional; Region: PRK04311 454169011268 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 454169011269 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 454169011270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169011271 catalytic residue [active] 454169011272 putative glutathione S-transferase; Provisional; Region: PRK10357 454169011273 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 454169011274 putative C-terminal domain interface [polypeptide binding]; other site 454169011275 putative GSH binding site (G-site) [chemical binding]; other site 454169011276 putative dimer interface [polypeptide binding]; other site 454169011277 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 454169011278 dimer interface [polypeptide binding]; other site 454169011279 N-terminal domain interface [polypeptide binding]; other site 454169011280 putative substrate binding pocket (H-site) [chemical binding]; other site 454169011281 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 454169011282 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 454169011283 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 454169011284 active site 454169011285 P-loop; other site 454169011286 phosphorylation site [posttranslational modification] 454169011287 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169011288 active site 454169011289 phosphorylation site [posttranslational modification] 454169011290 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 454169011291 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454169011292 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454169011293 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 454169011294 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 454169011295 hypothetical protein; Provisional; Region: PRK11020 454169011296 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 454169011297 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 454169011298 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 454169011299 trimer interface [polypeptide binding]; other site 454169011300 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 454169011301 Haemagglutinin; Region: HIM; pfam05662 454169011302 Haemagglutinin; Region: HIM; pfam05662 454169011303 YadA-like C-terminal region; Region: YadA; pfam03895 454169011304 L-lactate permease; Provisional; Region: PRK10420 454169011305 glycolate transporter; Provisional; Region: PRK09695 454169011306 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 454169011307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169011308 DNA-binding site [nucleotide binding]; DNA binding site 454169011309 FCD domain; Region: FCD; pfam07729 454169011310 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 454169011311 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 454169011312 active site 454169011313 substrate binding site [chemical binding]; other site 454169011314 FMN binding site [chemical binding]; other site 454169011315 putative catalytic residues [active] 454169011316 putative rRNA methylase; Provisional; Region: PRK10358 454169011317 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454169011318 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169011319 DNA binding site [nucleotide binding] 454169011320 domain linker motif; other site 454169011321 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454169011322 putative dimerization interface [polypeptide binding]; other site 454169011323 putative ligand binding site [chemical binding]; other site 454169011324 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 454169011325 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 454169011326 active site pocket [active] 454169011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011328 D-galactonate transporter; Region: 2A0114; TIGR00893 454169011329 putative substrate translocation pore; other site 454169011330 serine acetyltransferase; Provisional; Region: cysE; PRK11132 454169011331 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 454169011332 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 454169011333 trimer interface [polypeptide binding]; other site 454169011334 active site 454169011335 substrate binding site [chemical binding]; other site 454169011336 CoA binding site [chemical binding]; other site 454169011337 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 454169011338 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 454169011339 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 454169011340 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 454169011341 SecA binding site; other site 454169011342 Preprotein binding site; other site 454169011343 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 454169011344 GSH binding site [chemical binding]; other site 454169011345 catalytic residues [active] 454169011346 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 454169011347 active site residue [active] 454169011348 phosphoglyceromutase; Provisional; Region: PRK05434 454169011349 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 454169011350 AmiB activator; Provisional; Region: PRK11637 454169011351 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 454169011352 Peptidase family M23; Region: Peptidase_M23; pfam01551 454169011353 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 454169011354 NodB motif; other site 454169011355 putative active site [active] 454169011356 putative catalytic site [active] 454169011357 Zn binding site [ion binding]; other site 454169011358 putative glycosyl transferase; Provisional; Region: PRK10073 454169011359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 454169011360 active site 454169011361 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 454169011362 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 454169011363 NAD(P) binding site [chemical binding]; other site 454169011364 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 454169011365 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 454169011366 substrate-cofactor binding pocket; other site 454169011367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169011368 catalytic residue [active] 454169011369 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 454169011370 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 454169011371 NADP binding site [chemical binding]; other site 454169011372 homopentamer interface [polypeptide binding]; other site 454169011373 substrate binding site [chemical binding]; other site 454169011374 active site 454169011375 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 454169011376 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 454169011377 putative active site [active] 454169011378 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 454169011379 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 454169011380 putative active site [active] 454169011381 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 454169011382 O-antigen ligase RfaL; Provisional; Region: PRK15487 454169011383 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 454169011384 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 454169011385 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 454169011386 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 454169011387 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 454169011388 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 454169011389 Ligand binding site; other site 454169011390 metal-binding site 454169011391 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 454169011392 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 454169011393 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 454169011394 Ligand binding site; other site 454169011395 metal-binding site 454169011396 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 454169011397 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 454169011398 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 454169011399 putative ADP-binding pocket [chemical binding]; other site 454169011400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169011401 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 454169011402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 454169011403 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 454169011404 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 454169011405 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 454169011406 putative active site [active] 454169011407 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 454169011408 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 454169011409 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454169011410 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 454169011411 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 454169011412 active site 454169011413 (T/H)XGH motif; other site 454169011414 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 454169011415 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 454169011416 DNA binding site [nucleotide binding] 454169011417 catalytic residue [active] 454169011418 H2TH interface [polypeptide binding]; other site 454169011419 putative catalytic residues [active] 454169011420 turnover-facilitating residue; other site 454169011421 intercalation triad [nucleotide binding]; other site 454169011422 8OG recognition residue [nucleotide binding]; other site 454169011423 putative reading head residues; other site 454169011424 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 454169011425 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 454169011426 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 454169011427 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 454169011428 hypothetical protein; Reviewed; Region: PRK00024 454169011429 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 454169011430 MPN+ (JAMM) motif; other site 454169011431 Zinc-binding site [ion binding]; other site 454169011432 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 454169011433 Flavoprotein; Region: Flavoprotein; pfam02441 454169011434 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 454169011435 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 454169011436 trimer interface [polypeptide binding]; other site 454169011437 active site 454169011438 division inhibitor protein; Provisional; Region: slmA; PRK09480 454169011439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169011440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454169011441 active site 454169011442 ribonuclease PH; Reviewed; Region: rph; PRK00173 454169011443 Ribonuclease PH; Region: RNase_PH_bact; cd11362 454169011444 hexamer interface [polypeptide binding]; other site 454169011445 active site 454169011446 hypothetical protein; Provisional; Region: PRK11820 454169011447 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 454169011448 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 454169011449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169011450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169011451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454169011452 dimerization interface [polypeptide binding]; other site 454169011453 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 454169011454 Predicted membrane protein [Function unknown]; Region: COG2860 454169011455 UPF0126 domain; Region: UPF0126; pfam03458 454169011456 UPF0126 domain; Region: UPF0126; pfam03458 454169011457 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 454169011458 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 454169011459 nucleotide binding pocket [chemical binding]; other site 454169011460 K-X-D-G motif; other site 454169011461 catalytic site [active] 454169011462 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 454169011463 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 454169011464 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 454169011465 catalytic site [active] 454169011466 G-X2-G-X-G-K; other site 454169011467 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 454169011468 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 454169011469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454169011470 Zn2+ binding site [ion binding]; other site 454169011471 Mg2+ binding site [ion binding]; other site 454169011472 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 454169011473 synthetase active site [active] 454169011474 NTP binding site [chemical binding]; other site 454169011475 metal binding site [ion binding]; metal-binding site 454169011476 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 454169011477 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 454169011478 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 454169011479 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 454169011480 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 454169011481 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 454169011482 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 454169011483 generic binding surface II; other site 454169011484 ssDNA binding site; other site 454169011485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169011486 ATP binding site [chemical binding]; other site 454169011487 putative Mg++ binding site [ion binding]; other site 454169011488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169011489 nucleotide binding region [chemical binding]; other site 454169011490 ATP-binding site [chemical binding]; other site 454169011491 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 454169011492 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 454169011493 AsmA family; Region: AsmA; pfam05170 454169011494 putative alpha-glucosidase; Provisional; Region: PRK10658 454169011495 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 454169011496 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 454169011497 active site 454169011498 homotrimer interface [polypeptide binding]; other site 454169011499 catalytic site [active] 454169011500 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 454169011501 putative transporter; Provisional; Region: PRK11462 454169011502 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454169011503 Virulence protein [General function prediction only]; Region: COG3943 454169011504 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 454169011505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 454169011506 Transposase; Region: HTH_Tnp_1; pfam01527 454169011507 autotransport protein MisL; Provisional; Region: PRK15313 454169011508 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 454169011509 Autotransporter beta-domain; Region: Autotransporter; pfam03797 454169011510 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 454169011511 DNA binding site [nucleotide binding] 454169011512 Transposase domain (DUF772); Region: DUF772; pfam05598 454169011513 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169011514 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169011515 Isochorismatase family; Region: Isochorismatase; pfam00857 454169011516 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 454169011517 catalytic triad [active] 454169011518 dimer interface [polypeptide binding]; other site 454169011519 conserved cis-peptide bond; other site 454169011520 magnesium-transporting ATPase; Provisional; Region: PRK15122 454169011521 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 454169011522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454169011523 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 454169011524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169011525 motif II; other site 454169011526 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 454169011527 magnesium transport protein MgtC; Provisional; Region: PRK15385 454169011528 MgtC family; Region: MgtC; pfam02308 454169011529 EamA-like transporter family; Region: EamA; pfam00892 454169011530 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 454169011531 EamA-like transporter family; Region: EamA; pfam00892 454169011532 hypothetical protein; Provisional; Region: PRK09956 454169011533 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454169011534 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 454169011535 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 454169011536 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 454169011537 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 454169011538 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 454169011539 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 454169011540 active site 454169011541 phosphorylation site [posttranslational modification] 454169011542 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454169011543 active pocket/dimerization site; other site 454169011544 active site 454169011545 phosphorylation site [posttranslational modification] 454169011546 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 454169011547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169011548 Walker A motif; other site 454169011549 ATP binding site [chemical binding]; other site 454169011550 Walker B motif; other site 454169011551 arginine finger; other site 454169011552 Transcriptional antiterminator [Transcription]; Region: COG3933 454169011553 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 454169011554 active site 454169011555 active pocket/dimerization site; other site 454169011556 phosphorylation site [posttranslational modification] 454169011557 PRD domain; Region: PRD; pfam00874 454169011558 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 454169011559 beta-galactosidase; Region: BGL; TIGR03356 454169011560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 454169011561 Predicted transcriptional regulator [Transcription]; Region: COG2944 454169011562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169011563 non-specific DNA binding site [nucleotide binding]; other site 454169011564 salt bridge; other site 454169011565 sequence-specific DNA binding site [nucleotide binding]; other site 454169011566 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454169011567 dimerization domain swap beta strand [polypeptide binding]; other site 454169011568 regulatory protein interface [polypeptide binding]; other site 454169011569 active site 454169011570 regulatory phosphorylation site [posttranslational modification]; other site 454169011571 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 454169011572 intersubunit interface [polypeptide binding]; other site 454169011573 active site 454169011574 zinc binding site [ion binding]; other site 454169011575 Na+ binding site [ion binding]; other site 454169011576 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 454169011577 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 454169011578 putative N- and C-terminal domain interface [polypeptide binding]; other site 454169011579 putative active site [active] 454169011580 putative MgATP binding site [chemical binding]; other site 454169011581 catalytic site [active] 454169011582 metal binding site [ion binding]; metal-binding site 454169011583 putative carbohydrate binding site [chemical binding]; other site 454169011584 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454169011585 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 454169011586 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454169011587 active site 454169011588 P-loop; other site 454169011589 phosphorylation site [posttranslational modification] 454169011590 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169011591 active site 454169011592 phosphorylation site [posttranslational modification] 454169011593 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454169011594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169011595 DNA-binding site [nucleotide binding]; DNA binding site 454169011596 UTRA domain; Region: UTRA; pfam07702 454169011597 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 454169011598 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 454169011599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011600 putative substrate translocation pore; other site 454169011601 regulatory protein UhpC; Provisional; Region: PRK11663 454169011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011603 putative substrate translocation pore; other site 454169011604 sensory histidine kinase UhpB; Provisional; Region: PRK11644 454169011605 MASE1; Region: MASE1; pfam05231 454169011606 Histidine kinase; Region: HisKA_3; pfam07730 454169011607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169011608 ATP binding site [chemical binding]; other site 454169011609 Mg2+ binding site [ion binding]; other site 454169011610 G-X-G motif; other site 454169011611 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 454169011612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169011613 active site 454169011614 phosphorylation site [posttranslational modification] 454169011615 intermolecular recognition site; other site 454169011616 dimerization interface [polypeptide binding]; other site 454169011617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169011618 DNA binding residues [nucleotide binding] 454169011619 dimerization interface [polypeptide binding]; other site 454169011620 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 454169011621 active site 454169011622 catalytic residues [active] 454169011623 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 454169011624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011625 putative substrate translocation pore; other site 454169011626 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169011627 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454169011628 substrate binding site [chemical binding]; other site 454169011629 dimer interface [polypeptide binding]; other site 454169011630 ATP binding site [chemical binding]; other site 454169011631 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 454169011632 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 454169011633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169011634 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 454169011635 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 454169011636 putative valine binding site [chemical binding]; other site 454169011637 dimer interface [polypeptide binding]; other site 454169011638 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 454169011639 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454169011640 PYR/PP interface [polypeptide binding]; other site 454169011641 dimer interface [polypeptide binding]; other site 454169011642 TPP binding site [chemical binding]; other site 454169011643 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454169011644 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 454169011645 TPP-binding site [chemical binding]; other site 454169011646 dimer interface [polypeptide binding]; other site 454169011647 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 454169011648 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 454169011649 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 454169011650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011651 putative substrate translocation pore; other site 454169011652 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 454169011653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169011654 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 454169011655 dimerization interface [polypeptide binding]; other site 454169011656 substrate binding pocket [chemical binding]; other site 454169011657 permease DsdX; Provisional; Region: PRK09921 454169011658 gluconate transporter; Region: gntP; TIGR00791 454169011659 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 454169011660 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 454169011661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454169011662 catalytic residue [active] 454169011663 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 454169011664 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454169011665 Domain of unknown function (DUF202); Region: DUF202; pfam02656 454169011666 Predicted membrane protein [Function unknown]; Region: COG2149 454169011667 putative transporter; Validated; Region: PRK03818 454169011668 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 454169011669 TrkA-C domain; Region: TrkA_C; pfam02080 454169011670 TrkA-C domain; Region: TrkA_C; pfam02080 454169011671 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 454169011672 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 454169011673 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 454169011674 putative dimer interface [polypeptide binding]; other site 454169011675 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 454169011676 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 454169011677 putative dimer interface [polypeptide binding]; other site 454169011678 hypothetical protein; Provisional; Region: PRK11616 454169011679 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 454169011680 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 454169011681 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 454169011682 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 454169011683 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 454169011684 catalytic residues [active] 454169011685 central insert; other site 454169011686 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 454169011687 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 454169011688 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 454169011689 heme exporter protein CcmC; Region: ccmC; TIGR01191 454169011690 heme exporter protein CcmB; Region: ccmB; TIGR01190 454169011691 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 454169011692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169011693 Walker A/P-loop; other site 454169011694 ATP binding site [chemical binding]; other site 454169011695 Q-loop/lid; other site 454169011696 ABC transporter signature motif; other site 454169011697 Walker B; other site 454169011698 D-loop; other site 454169011699 H-loop/switch region; other site 454169011700 Haem-binding domain; Region: Haem_bd; pfam14376 454169011701 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 454169011702 chaperone protein TorD; Validated; Region: torD; PRK04976 454169011703 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 454169011704 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 454169011705 molybdopterin cofactor binding site [chemical binding]; other site 454169011706 substrate binding site [chemical binding]; other site 454169011707 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 454169011708 molybdopterin cofactor binding site; other site 454169011709 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 454169011710 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 454169011711 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 454169011712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169011713 active site 454169011714 phosphorylation site [posttranslational modification] 454169011715 intermolecular recognition site; other site 454169011716 dimerization interface [polypeptide binding]; other site 454169011717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169011718 DNA binding site [nucleotide binding] 454169011719 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 454169011720 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 454169011721 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 454169011722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169011723 dimer interface [polypeptide binding]; other site 454169011724 phosphorylation site [posttranslational modification] 454169011725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169011726 ATP binding site [chemical binding]; other site 454169011727 Mg2+ binding site [ion binding]; other site 454169011728 G-X-G motif; other site 454169011729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169011730 active site 454169011731 phosphorylation site [posttranslational modification] 454169011732 intermolecular recognition site; other site 454169011733 dimerization interface [polypeptide binding]; other site 454169011734 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454169011735 putative binding surface; other site 454169011736 active site 454169011737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011738 D-galactonate transporter; Region: 2A0114; TIGR00893 454169011739 putative substrate translocation pore; other site 454169011740 galactonate dehydratase; Provisional; Region: PRK14017 454169011741 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 454169011742 putative active site pocket [active] 454169011743 putative metal binding site [ion binding]; other site 454169011744 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 454169011745 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 454169011746 active site 454169011747 intersubunit interface [polypeptide binding]; other site 454169011748 catalytic residue [active] 454169011749 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 454169011750 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 454169011751 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454169011752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169011753 DNA-binding site [nucleotide binding]; DNA binding site 454169011754 FCD domain; Region: FCD; pfam07729 454169011755 sugar phosphate phosphatase; Provisional; Region: PRK10513 454169011756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169011757 active site 454169011758 motif I; other site 454169011759 motif II; other site 454169011760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169011761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011762 D-galactonate transporter; Region: 2A0114; TIGR00893 454169011763 putative substrate translocation pore; other site 454169011764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011765 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 454169011766 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 454169011767 active site pocket [active] 454169011768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169011769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169011770 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 454169011771 putative dimerization interface [polypeptide binding]; other site 454169011772 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 454169011773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169011774 Mg2+ binding site [ion binding]; other site 454169011775 G-X-G motif; other site 454169011776 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 454169011777 anchoring element; other site 454169011778 dimer interface [polypeptide binding]; other site 454169011779 ATP binding site [chemical binding]; other site 454169011780 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 454169011781 active site 454169011782 putative metal-binding site [ion binding]; other site 454169011783 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 454169011784 recF protein; Region: recf; TIGR00611 454169011785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169011786 Walker A/P-loop; other site 454169011787 ATP binding site [chemical binding]; other site 454169011788 Q-loop/lid; other site 454169011789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169011790 ABC transporter signature motif; other site 454169011791 Walker B; other site 454169011792 D-loop; other site 454169011793 H-loop/switch region; other site 454169011794 DNA polymerase III subunit beta; Validated; Region: PRK05643 454169011795 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 454169011796 putative DNA binding surface [nucleotide binding]; other site 454169011797 dimer interface [polypeptide binding]; other site 454169011798 beta-clamp/clamp loader binding surface; other site 454169011799 beta-clamp/translesion DNA polymerase binding surface; other site 454169011800 DnaA N-terminal domain; Region: DnaA_N; pfam11638 454169011801 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 454169011802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169011803 Walker A motif; other site 454169011804 ATP binding site [chemical binding]; other site 454169011805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 454169011806 Walker B motif; other site 454169011807 arginine finger; other site 454169011808 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 454169011809 DnaA box-binding interface [nucleotide binding]; other site 454169011810 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 454169011811 ribonuclease P; Reviewed; Region: rnpA; PRK01732 454169011812 membrane protein insertase; Provisional; Region: PRK01318 454169011813 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 454169011814 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 454169011815 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 454169011816 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 454169011817 trmE is a tRNA modification GTPase; Region: trmE; cd04164 454169011818 G1 box; other site 454169011819 GTP/Mg2+ binding site [chemical binding]; other site 454169011820 Switch I region; other site 454169011821 G2 box; other site 454169011822 Switch II region; other site 454169011823 G3 box; other site 454169011824 G4 box; other site 454169011825 G5 box; other site 454169011826 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 454169011827 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 454169011828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011829 putative substrate translocation pore; other site 454169011830 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 454169011831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169011832 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 454169011833 substrate binding pocket [chemical binding]; other site 454169011834 dimerization interface [polypeptide binding]; other site 454169011835 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 454169011836 Predicted flavoprotein [General function prediction only]; Region: COG0431 454169011837 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 454169011838 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 454169011839 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 454169011840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169011841 active site 454169011842 motif I; other site 454169011843 motif II; other site 454169011844 transcriptional regulator PhoU; Provisional; Region: PRK11115 454169011845 PhoU domain; Region: PhoU; pfam01895 454169011846 PhoU domain; Region: PhoU; pfam01895 454169011847 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 454169011848 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 454169011849 Walker A/P-loop; other site 454169011850 ATP binding site [chemical binding]; other site 454169011851 Q-loop/lid; other site 454169011852 ABC transporter signature motif; other site 454169011853 Walker B; other site 454169011854 D-loop; other site 454169011855 H-loop/switch region; other site 454169011856 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 454169011857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169011858 dimer interface [polypeptide binding]; other site 454169011859 conserved gate region; other site 454169011860 putative PBP binding loops; other site 454169011861 ABC-ATPase subunit interface; other site 454169011862 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 454169011863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169011864 dimer interface [polypeptide binding]; other site 454169011865 conserved gate region; other site 454169011866 putative PBP binding loops; other site 454169011867 ABC-ATPase subunit interface; other site 454169011868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169011869 substrate binding pocket [chemical binding]; other site 454169011870 membrane-bound complex binding site; other site 454169011871 hinge residues; other site 454169011872 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 454169011873 active site 454169011874 P-loop; other site 454169011875 phosphorylation site [posttranslational modification] 454169011876 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 454169011877 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 454169011878 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 454169011879 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 454169011880 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 454169011881 shikimate binding site; other site 454169011882 NAD(P) binding site [chemical binding]; other site 454169011883 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 454169011884 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454169011885 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 454169011886 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 454169011887 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 454169011888 glutaminase active site [active] 454169011889 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 454169011890 dimer interface [polypeptide binding]; other site 454169011891 active site 454169011892 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454169011893 dimer interface [polypeptide binding]; other site 454169011894 active site 454169011895 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 454169011896 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 454169011897 Substrate binding site; other site 454169011898 Mg++ binding site; other site 454169011899 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 454169011900 active site 454169011901 substrate binding site [chemical binding]; other site 454169011902 CoA binding site [chemical binding]; other site 454169011903 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454169011904 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 454169011905 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 454169011906 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 454169011907 gamma subunit interface [polypeptide binding]; other site 454169011908 epsilon subunit interface [polypeptide binding]; other site 454169011909 LBP interface [polypeptide binding]; other site 454169011910 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 454169011911 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 454169011912 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 454169011913 alpha subunit interaction interface [polypeptide binding]; other site 454169011914 Walker A motif; other site 454169011915 ATP binding site [chemical binding]; other site 454169011916 Walker B motif; other site 454169011917 inhibitor binding site; inhibition site 454169011918 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 454169011919 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 454169011920 core domain interface [polypeptide binding]; other site 454169011921 delta subunit interface [polypeptide binding]; other site 454169011922 epsilon subunit interface [polypeptide binding]; other site 454169011923 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 454169011924 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 454169011925 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 454169011926 beta subunit interaction interface [polypeptide binding]; other site 454169011927 Walker A motif; other site 454169011928 ATP binding site [chemical binding]; other site 454169011929 Walker B motif; other site 454169011930 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 454169011931 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 454169011932 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 454169011933 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 454169011934 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 454169011935 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 454169011936 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 454169011937 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 454169011938 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 454169011939 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 454169011940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169011941 S-adenosylmethionine binding site [chemical binding]; other site 454169011942 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 454169011943 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 454169011944 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 454169011945 FMN-binding protein MioC; Provisional; Region: PRK09004 454169011946 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 454169011947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169011948 putative DNA binding site [nucleotide binding]; other site 454169011949 putative Zn2+ binding site [ion binding]; other site 454169011950 AsnC family; Region: AsnC_trans_reg; pfam01037 454169011951 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 454169011952 dimer interface [polypeptide binding]; other site 454169011953 active site 454169011954 hypothetical protein; Provisional; Region: yieM; PRK10997 454169011955 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 454169011956 metal ion-dependent adhesion site (MIDAS); other site 454169011957 regulatory ATPase RavA; Provisional; Region: PRK13531 454169011958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169011959 Walker A motif; other site 454169011960 ATP binding site [chemical binding]; other site 454169011961 Walker B motif; other site 454169011962 arginine finger; other site 454169011963 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 454169011964 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 454169011965 potassium uptake protein; Region: kup; TIGR00794 454169011966 D-ribose pyranase; Provisional; Region: PRK11797 454169011967 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 454169011968 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 454169011969 Walker A/P-loop; other site 454169011970 ATP binding site [chemical binding]; other site 454169011971 Q-loop/lid; other site 454169011972 ABC transporter signature motif; other site 454169011973 Walker B; other site 454169011974 D-loop; other site 454169011975 H-loop/switch region; other site 454169011976 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 454169011977 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454169011978 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454169011979 TM-ABC transporter signature motif; other site 454169011980 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 454169011981 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 454169011982 ligand binding site [chemical binding]; other site 454169011983 dimerization interface [polypeptide binding]; other site 454169011984 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169011985 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454169011986 substrate binding site [chemical binding]; other site 454169011987 dimer interface [polypeptide binding]; other site 454169011988 ATP binding site [chemical binding]; other site 454169011989 transcriptional repressor RbsR; Provisional; Region: PRK10423 454169011990 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169011991 DNA binding site [nucleotide binding] 454169011992 domain linker motif; other site 454169011993 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 454169011994 dimerization interface [polypeptide binding]; other site 454169011995 ligand binding site [chemical binding]; other site 454169011996 putative transporter; Provisional; Region: PRK10504 454169011997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169011998 putative substrate translocation pore; other site 454169011999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169012000 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454169012001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169012002 DNA-binding site [nucleotide binding]; DNA binding site 454169012003 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454169012004 transcriptional regulator HdfR; Provisional; Region: PRK03601 454169012005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169012006 LysR substrate binding domain; Region: LysR_substrate; pfam03466 454169012007 dimerization interface [polypeptide binding]; other site 454169012008 hypothetical protein; Provisional; Region: PRK11027 454169012009 putative ATP-dependent protease; Provisional; Region: PRK09862 454169012010 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 454169012011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169012012 Walker A motif; other site 454169012013 ATP binding site [chemical binding]; other site 454169012014 Walker B motif; other site 454169012015 arginine finger; other site 454169012016 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 454169012017 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 454169012018 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454169012019 PYR/PP interface [polypeptide binding]; other site 454169012020 dimer interface [polypeptide binding]; other site 454169012021 TPP binding site [chemical binding]; other site 454169012022 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454169012023 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 454169012024 TPP-binding site [chemical binding]; other site 454169012025 dimer interface [polypeptide binding]; other site 454169012026 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 454169012027 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 454169012028 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 454169012029 homodimer interface [polypeptide binding]; other site 454169012030 substrate-cofactor binding pocket; other site 454169012031 catalytic residue [active] 454169012032 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 454169012033 threonine dehydratase; Reviewed; Region: PRK09224 454169012034 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 454169012035 tetramer interface [polypeptide binding]; other site 454169012036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169012037 catalytic residue [active] 454169012038 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 454169012039 putative Ile/Val binding site [chemical binding]; other site 454169012040 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 454169012041 putative Ile/Val binding site [chemical binding]; other site 454169012042 Phage-related protein [Function unknown]; Region: COG4679 454169012043 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 454169012044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169012045 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 454169012046 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 454169012047 putative dimerization interface [polypeptide binding]; other site 454169012048 ketol-acid reductoisomerase; Validated; Region: PRK05225 454169012049 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 454169012050 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 454169012051 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 454169012052 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 454169012053 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 454169012054 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 454169012055 Part of AAA domain; Region: AAA_19; pfam13245 454169012056 Family description; Region: UvrD_C_2; pfam13538 454169012057 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 454169012058 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 454169012059 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 454169012060 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454169012061 ATP binding site [chemical binding]; other site 454169012062 Mg++ binding site [ion binding]; other site 454169012063 motif III; other site 454169012064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169012065 nucleotide binding region [chemical binding]; other site 454169012066 ATP-binding site [chemical binding]; other site 454169012067 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 454169012068 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 454169012069 catalytic residues [active] 454169012070 transcription termination factor Rho; Provisional; Region: rho; PRK09376 454169012071 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 454169012072 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 454169012073 RNA binding site [nucleotide binding]; other site 454169012074 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 454169012075 multimer interface [polypeptide binding]; other site 454169012076 Walker A motif; other site 454169012077 ATP binding site [chemical binding]; other site 454169012078 Walker B motif; other site 454169012079 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 454169012080 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 454169012081 Mg++ binding site [ion binding]; other site 454169012082 putative catalytic motif [active] 454169012083 substrate binding site [chemical binding]; other site 454169012084 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 454169012085 Chain length determinant protein; Region: Wzz; pfam02706 454169012086 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 454169012087 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 454169012088 active site 454169012089 homodimer interface [polypeptide binding]; other site 454169012090 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 454169012091 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 454169012092 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 454169012093 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 454169012094 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 454169012095 NAD binding site [chemical binding]; other site 454169012096 substrate binding site [chemical binding]; other site 454169012097 homodimer interface [polypeptide binding]; other site 454169012098 active site 454169012099 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 454169012100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454169012101 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 454169012102 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 454169012103 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 454169012104 inhibitor-cofactor binding pocket; inhibition site 454169012105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169012106 catalytic residue [active] 454169012107 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 454169012108 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 454169012109 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 454169012110 putative common antigen polymerase; Provisional; Region: PRK02975 454169012111 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 454169012112 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 454169012113 putative transport protein YifK; Provisional; Region: PRK10746 454169012114 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 454169012115 HemY protein N-terminus; Region: HemY_N; pfam07219 454169012116 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 454169012117 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 454169012118 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 454169012119 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 454169012120 active site 454169012121 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 454169012122 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 454169012123 domain interfaces; other site 454169012124 active site 454169012125 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 454169012126 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 454169012127 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 454169012128 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 454169012129 putative iron binding site [ion binding]; other site 454169012130 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 454169012131 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 454169012132 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 454169012133 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 454169012134 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 454169012135 hypothetical protein; Provisional; Region: PRK10963 454169012136 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 454169012137 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 454169012138 active site 454169012139 Int/Topo IB signature motif; other site 454169012140 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 454169012141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169012142 motif II; other site 454169012143 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 454169012144 Part of AAA domain; Region: AAA_19; pfam13245 454169012145 Family description; Region: UvrD_C_2; pfam13538 454169012146 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 454169012147 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 454169012148 Cl binding site [ion binding]; other site 454169012149 oligomer interface [polypeptide binding]; other site 454169012150 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 454169012151 EamA-like transporter family; Region: EamA; cl17759 454169012152 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 454169012153 CoenzymeA binding site [chemical binding]; other site 454169012154 subunit interaction site [polypeptide binding]; other site 454169012155 PHB binding site; other site 454169012156 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 454169012157 dimerization interface [polypeptide binding]; other site 454169012158 substrate binding site [chemical binding]; other site 454169012159 active site 454169012160 calcium binding site [ion binding]; other site 454169012161 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 454169012162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169012163 ATP binding site [chemical binding]; other site 454169012164 putative Mg++ binding site [ion binding]; other site 454169012165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169012166 nucleotide binding region [chemical binding]; other site 454169012167 ATP-binding site [chemical binding]; other site 454169012168 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 454169012169 Helicase and RNase D C-terminal; Region: HRDC; smart00341 454169012170 threonine efflux system; Provisional; Region: PRK10229 454169012171 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 454169012172 lysophospholipase L2; Provisional; Region: PRK10749 454169012173 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 454169012174 putative hydrolase; Provisional; Region: PRK10976 454169012175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169012176 active site 454169012177 motif I; other site 454169012178 motif II; other site 454169012179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169012180 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 454169012181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169012182 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 454169012183 putative dimerization interface [polypeptide binding]; other site 454169012184 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 454169012185 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 454169012186 THF binding site; other site 454169012187 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 454169012188 substrate binding site [chemical binding]; other site 454169012189 THF binding site; other site 454169012190 zinc-binding site [ion binding]; other site 454169012191 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454169012192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169012193 FeS/SAM binding site; other site 454169012194 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454169012195 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 454169012196 uridine phosphorylase; Provisional; Region: PRK11178 454169012197 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 454169012198 DNA recombination protein RmuC; Provisional; Region: PRK10361 454169012199 RmuC family; Region: RmuC; pfam02646 454169012200 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 454169012201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169012202 S-adenosylmethionine binding site [chemical binding]; other site 454169012203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 454169012204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 454169012205 SCP-2 sterol transfer family; Region: SCP2; pfam02036 454169012206 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 454169012207 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 454169012208 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 454169012209 sec-independent translocase; Provisional; Region: PRK01770 454169012210 sec-independent translocase; Provisional; Region: tatB; PRK00404 454169012211 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 454169012212 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 454169012213 active site 454169012214 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 454169012215 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 454169012216 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 454169012217 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 454169012218 FMN reductase; Validated; Region: fre; PRK08051 454169012219 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 454169012220 FAD binding pocket [chemical binding]; other site 454169012221 FAD binding motif [chemical binding]; other site 454169012222 phosphate binding motif [ion binding]; other site 454169012223 beta-alpha-beta structure motif; other site 454169012224 NAD binding pocket [chemical binding]; other site 454169012225 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454169012226 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 454169012227 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 454169012228 dimer interface [polypeptide binding]; other site 454169012229 active site 454169012230 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 454169012231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454169012232 substrate binding site [chemical binding]; other site 454169012233 oxyanion hole (OAH) forming residues; other site 454169012234 trimer interface [polypeptide binding]; other site 454169012235 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 454169012236 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 454169012237 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 454169012238 proline dipeptidase; Provisional; Region: PRK13607 454169012239 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 454169012240 active site 454169012241 hypothetical protein; Provisional; Region: PRK11568 454169012242 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 454169012243 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 454169012244 potassium transporter; Provisional; Region: PRK10750 454169012245 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 454169012246 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 454169012247 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 454169012248 Walker A motif; other site 454169012249 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 454169012250 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 454169012251 GTP binding site; other site 454169012252 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 454169012253 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 454169012254 serine/threonine protein kinase; Provisional; Region: PRK11768 454169012255 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 454169012256 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454169012257 catalytic residues [active] 454169012258 hinge region; other site 454169012259 alpha helical domain; other site 454169012260 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 454169012261 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 454169012262 putative acyl-acceptor binding pocket; other site 454169012263 DNA polymerase I; Provisional; Region: PRK05755 454169012264 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 454169012265 active site 454169012266 metal binding site 1 [ion binding]; metal-binding site 454169012267 putative 5' ssDNA interaction site; other site 454169012268 metal binding site 3; metal-binding site 454169012269 metal binding site 2 [ion binding]; metal-binding site 454169012270 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 454169012271 putative DNA binding site [nucleotide binding]; other site 454169012272 putative metal binding site [ion binding]; other site 454169012273 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 454169012274 active site 454169012275 catalytic site [active] 454169012276 substrate binding site [chemical binding]; other site 454169012277 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 454169012278 active site 454169012279 DNA binding site [nucleotide binding] 454169012280 catalytic site [active] 454169012281 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 454169012282 G1 box; other site 454169012283 GTP/Mg2+ binding site [chemical binding]; other site 454169012284 Switch I region; other site 454169012285 G2 box; other site 454169012286 G3 box; other site 454169012287 Switch II region; other site 454169012288 G4 box; other site 454169012289 G5 box; other site 454169012290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 454169012291 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 454169012292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169012293 FeS/SAM binding site; other site 454169012294 HemN C-terminal domain; Region: HemN_C; pfam06969 454169012295 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 454169012296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169012297 active site 454169012298 phosphorylation site [posttranslational modification] 454169012299 intermolecular recognition site; other site 454169012300 dimerization interface [polypeptide binding]; other site 454169012301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169012302 Walker A motif; other site 454169012303 ATP binding site [chemical binding]; other site 454169012304 Walker B motif; other site 454169012305 arginine finger; other site 454169012306 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454169012307 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 454169012308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454169012309 putative active site [active] 454169012310 heme pocket [chemical binding]; other site 454169012311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169012312 dimer interface [polypeptide binding]; other site 454169012313 phosphorylation site [posttranslational modification] 454169012314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169012315 ATP binding site [chemical binding]; other site 454169012316 Mg2+ binding site [ion binding]; other site 454169012317 G-X-G motif; other site 454169012318 glutamine synthetase; Provisional; Region: glnA; PRK09469 454169012319 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 454169012320 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 454169012321 GTP-binding protein; Provisional; Region: PRK10218 454169012322 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 454169012323 G1 box; other site 454169012324 putative GEF interaction site [polypeptide binding]; other site 454169012325 GTP/Mg2+ binding site [chemical binding]; other site 454169012326 Switch I region; other site 454169012327 G2 box; other site 454169012328 G3 box; other site 454169012329 Switch II region; other site 454169012330 G4 box; other site 454169012331 G5 box; other site 454169012332 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 454169012333 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 454169012334 outer membrane porin L; Provisional; Region: ompL; PRK09980 454169012335 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 454169012336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169012337 putative substrate translocation pore; other site 454169012338 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 454169012339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169012340 putative substrate translocation pore; other site 454169012341 alpha-glucosidase; Provisional; Region: PRK10426 454169012342 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 454169012343 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 454169012344 putative active site [active] 454169012345 putative catalytic site [active] 454169012346 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 454169012347 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 454169012348 active site 454169012349 catalytic residues [active] 454169012350 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 454169012351 dimerization interface [polypeptide binding]; other site 454169012352 putative active cleft [active] 454169012353 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 454169012354 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 454169012355 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454169012356 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169012357 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 454169012358 substrate binding site [chemical binding]; other site 454169012359 ATP binding site [chemical binding]; other site 454169012360 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454169012361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169012362 putative DNA binding site [nucleotide binding]; other site 454169012363 putative Zn2+ binding site [ion binding]; other site 454169012364 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169012365 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 454169012366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169012367 motif II; other site 454169012368 hypothetical protein; Reviewed; Region: PRK01637 454169012369 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 454169012370 putative active site [active] 454169012371 dimerization interface [polypeptide binding]; other site 454169012372 putative tRNAtyr binding site [nucleotide binding]; other site 454169012373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169012374 Coenzyme A binding pocket [chemical binding]; other site 454169012375 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 454169012376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169012377 non-specific DNA binding site [nucleotide binding]; other site 454169012378 salt bridge; other site 454169012379 sequence-specific DNA binding site [nucleotide binding]; other site 454169012380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 454169012381 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 454169012382 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 454169012383 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 454169012384 Predicted transcriptional regulator [Transcription]; Region: COG2944 454169012385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169012386 non-specific DNA binding site [nucleotide binding]; other site 454169012387 salt bridge; other site 454169012388 sequence-specific DNA binding site [nucleotide binding]; other site 454169012389 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 454169012390 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 454169012391 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 454169012392 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 454169012393 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 454169012394 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 454169012395 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 454169012396 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 454169012397 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 454169012398 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 454169012399 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 454169012400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169012401 non-specific DNA binding site [nucleotide binding]; other site 454169012402 salt bridge; other site 454169012403 sequence-specific DNA binding site [nucleotide binding]; other site 454169012404 Cupin domain; Region: Cupin_2; cl17218 454169012405 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 454169012406 lactaldehyde reductase; Region: lactal_redase; TIGR02638 454169012407 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 454169012408 dimer interface [polypeptide binding]; other site 454169012409 active site 454169012410 metal binding site [ion binding]; metal-binding site 454169012411 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454169012412 intersubunit interface [polypeptide binding]; other site 454169012413 active site 454169012414 Zn2+ binding site [ion binding]; other site 454169012415 L-rhamnose isomerase; Provisional; Region: PRK01076 454169012416 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 454169012417 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 454169012418 N- and C-terminal domain interface [polypeptide binding]; other site 454169012419 active site 454169012420 putative catalytic site [active] 454169012421 metal binding site [ion binding]; metal-binding site 454169012422 ATP binding site [chemical binding]; other site 454169012423 rhamnulokinase; Provisional; Region: rhaB; PRK10640 454169012424 carbohydrate binding site [chemical binding]; other site 454169012425 transcriptional activator RhaS; Provisional; Region: PRK13503 454169012426 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454169012427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169012428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169012429 transcriptional activator RhaR; Provisional; Region: PRK13502 454169012430 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454169012431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169012432 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 454169012433 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 454169012434 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 454169012435 DctM-like transporters; Region: DctM; pfam06808 454169012436 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 454169012437 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 454169012438 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 454169012439 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 454169012440 superoxide dismutase; Provisional; Region: PRK10925 454169012441 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 454169012442 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 454169012443 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 454169012444 MOSC domain; Region: MOSC; pfam03473 454169012445 3-alpha domain; Region: 3-alpha; pfam03475 454169012446 SnoaL-like domain; Region: SnoaL_2; pfam12680 454169012447 two-component sensor protein; Provisional; Region: cpxA; PRK09470 454169012448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169012449 dimerization interface [polypeptide binding]; other site 454169012450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169012451 dimer interface [polypeptide binding]; other site 454169012452 phosphorylation site [posttranslational modification] 454169012453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169012454 ATP binding site [chemical binding]; other site 454169012455 Mg2+ binding site [ion binding]; other site 454169012456 G-X-G motif; other site 454169012457 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 454169012458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169012459 active site 454169012460 intermolecular recognition site; other site 454169012461 dimerization interface [polypeptide binding]; other site 454169012462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169012463 DNA binding site [nucleotide binding] 454169012464 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454169012465 dimer interface [polypeptide binding]; other site 454169012466 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 454169012467 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 454169012468 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 454169012469 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 454169012470 active site 454169012471 ADP/pyrophosphate binding site [chemical binding]; other site 454169012472 dimerization interface [polypeptide binding]; other site 454169012473 allosteric effector site; other site 454169012474 fructose-1,6-bisphosphate binding site; other site 454169012475 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454169012476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169012477 substrate binding pocket [chemical binding]; other site 454169012478 membrane-bound complex binding site; other site 454169012479 hinge residues; other site 454169012480 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 454169012481 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454169012482 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 454169012483 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454169012484 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 454169012485 putative substrate binding site [chemical binding]; other site 454169012486 putative ATP binding site [chemical binding]; other site 454169012487 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 454169012488 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454169012489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169012490 DNA-binding site [nucleotide binding]; DNA binding site 454169012491 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 454169012492 UTRA domain; Region: UTRA; pfam07702 454169012493 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 454169012494 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 454169012495 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 454169012496 putative N- and C-terminal domain interface [polypeptide binding]; other site 454169012497 putative active site [active] 454169012498 putative MgATP binding site [chemical binding]; other site 454169012499 catalytic site [active] 454169012500 metal binding site [ion binding]; metal-binding site 454169012501 putative carbohydrate binding site [chemical binding]; other site 454169012502 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454169012503 transcriptional regulator LsrR; Provisional; Region: PRK15418 454169012504 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 454169012505 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 454169012506 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 454169012507 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 454169012508 Walker A/P-loop; other site 454169012509 ATP binding site [chemical binding]; other site 454169012510 Q-loop/lid; other site 454169012511 ABC transporter signature motif; other site 454169012512 Walker B; other site 454169012513 D-loop; other site 454169012514 H-loop/switch region; other site 454169012515 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 454169012516 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454169012517 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454169012518 TM-ABC transporter signature motif; other site 454169012519 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454169012520 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454169012521 TM-ABC transporter signature motif; other site 454169012522 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 454169012523 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 454169012524 ligand binding site [chemical binding]; other site 454169012525 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 454169012526 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 454169012527 putative active site; other site 454169012528 catalytic residue [active] 454169012529 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 454169012530 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 454169012531 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454169012532 substrate binding site [chemical binding]; other site 454169012533 hexamer interface [polypeptide binding]; other site 454169012534 metal binding site [ion binding]; metal-binding site 454169012535 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 454169012536 triosephosphate isomerase; Provisional; Region: PRK14567 454169012537 substrate binding site [chemical binding]; other site 454169012538 dimer interface [polypeptide binding]; other site 454169012539 catalytic triad [active] 454169012540 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 454169012541 Predicted membrane protein [Function unknown]; Region: COG3152 454169012542 ferredoxin-NADP reductase; Provisional; Region: PRK10926 454169012543 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 454169012544 FAD binding pocket [chemical binding]; other site 454169012545 FAD binding motif [chemical binding]; other site 454169012546 phosphate binding motif [ion binding]; other site 454169012547 beta-alpha-beta structure motif; other site 454169012548 NAD binding pocket [chemical binding]; other site 454169012549 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 454169012550 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 454169012551 putative active site [active] 454169012552 glycerol kinase; Provisional; Region: glpK; PRK00047 454169012553 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 454169012554 N- and C-terminal domain interface [polypeptide binding]; other site 454169012555 active site 454169012556 MgATP binding site [chemical binding]; other site 454169012557 catalytic site [active] 454169012558 metal binding site [ion binding]; metal-binding site 454169012559 glycerol binding site [chemical binding]; other site 454169012560 homotetramer interface [polypeptide binding]; other site 454169012561 homodimer interface [polypeptide binding]; other site 454169012562 FBP binding site [chemical binding]; other site 454169012563 protein IIAGlc interface [polypeptide binding]; other site 454169012564 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 454169012565 amphipathic channel; other site 454169012566 Asn-Pro-Ala signature motifs; other site 454169012567 septal ring assembly protein ZapB; Provisional; Region: PRK15422 454169012568 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 454169012569 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 454169012570 UbiA prenyltransferase family; Region: UbiA; pfam01040 454169012571 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 454169012572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169012573 Walker A motif; other site 454169012574 ATP binding site [chemical binding]; other site 454169012575 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 454169012576 Walker B motif; other site 454169012577 arginine finger; other site 454169012578 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 454169012579 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 454169012580 active site 454169012581 HslU subunit interaction site [polypeptide binding]; other site 454169012582 essential cell division protein FtsN; Provisional; Region: PRK10927 454169012583 cell division protein FtsN; Provisional; Region: PRK12757 454169012584 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169012585 DNA binding site [nucleotide binding] 454169012586 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 454169012587 domain linker motif; other site 454169012588 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 454169012589 dimerization interface [polypeptide binding]; other site 454169012590 ligand binding site [chemical binding]; other site 454169012591 primosome assembly protein PriA; Validated; Region: PRK05580 454169012592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169012593 ATP binding site [chemical binding]; other site 454169012594 putative Mg++ binding site [ion binding]; other site 454169012595 helicase superfamily c-terminal domain; Region: HELICc; smart00490 454169012596 ATP-binding site [chemical binding]; other site 454169012597 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 454169012598 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 454169012599 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454169012600 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 454169012601 dimerization interface [polypeptide binding]; other site 454169012602 DNA binding site [nucleotide binding] 454169012603 corepressor binding sites; other site 454169012604 cystathionine gamma-synthase; Provisional; Region: PRK08045 454169012605 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 454169012606 homodimer interface [polypeptide binding]; other site 454169012607 substrate-cofactor binding pocket; other site 454169012608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169012609 catalytic residue [active] 454169012610 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 454169012611 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 454169012612 putative catalytic residues [active] 454169012613 putative nucleotide binding site [chemical binding]; other site 454169012614 putative aspartate binding site [chemical binding]; other site 454169012615 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 454169012616 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 454169012617 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 454169012618 mechanosensitive channel MscS; Provisional; Region: PRK10334 454169012619 Conserved TM helix; Region: TM_helix; pfam05552 454169012620 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169012621 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 454169012622 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 454169012623 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 454169012624 active site 454169012625 metal binding site [ion binding]; metal-binding site 454169012626 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454169012627 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 454169012628 FAD binding site [chemical binding]; other site 454169012629 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 454169012630 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 454169012631 heme binding site [chemical binding]; other site 454169012632 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 454169012633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 454169012634 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 454169012635 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 454169012636 dimer interface [polypeptide binding]; other site 454169012637 active site 454169012638 metal binding site [ion binding]; metal-binding site 454169012639 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 454169012640 active site 454169012641 intersubunit interactions; other site 454169012642 catalytic residue [active] 454169012643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454169012644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169012645 hypothetical protein; Provisional; Region: PRK10649 454169012646 Sulfatase; Region: Sulfatase; pfam00884 454169012647 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 454169012648 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 454169012649 acetylornithine deacetylase; Provisional; Region: PRK05111 454169012650 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 454169012651 metal binding site [ion binding]; metal-binding site 454169012652 putative dimer interface [polypeptide binding]; other site 454169012653 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 454169012654 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 454169012655 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 454169012656 nucleotide binding site [chemical binding]; other site 454169012657 N-acetyl-L-glutamate binding site [chemical binding]; other site 454169012658 argininosuccinate lyase; Provisional; Region: PRK04833 454169012659 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 454169012660 active sites [active] 454169012661 tetramer interface [polypeptide binding]; other site 454169012662 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 454169012663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169012664 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 454169012665 dimerization interface [polypeptide binding]; other site 454169012666 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 454169012667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454169012668 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454169012669 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 454169012670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169012671 hypothetical protein; Provisional; Region: PRK11056 454169012672 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 454169012673 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 454169012674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169012675 S-adenosylmethionine binding site [chemical binding]; other site 454169012676 Cobalamin riboswitch 454169012677 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 454169012678 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454169012679 N-terminal plug; other site 454169012680 ligand-binding site [chemical binding]; other site 454169012681 glutamate racemase; Provisional; Region: PRK00865 454169012682 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 454169012683 FAD binding domain; Region: FAD_binding_4; pfam01565 454169012684 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 454169012685 Biotin operon repressor [Transcription]; Region: BirA; COG1654 454169012686 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 454169012687 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 454169012688 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 454169012689 pantothenate kinase; Provisional; Region: PRK05439 454169012690 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 454169012691 ATP-binding site [chemical binding]; other site 454169012692 CoA-binding site [chemical binding]; other site 454169012693 Mg2+-binding site [ion binding]; other site 454169012694 elongation factor Tu; Reviewed; Region: PRK00049 454169012695 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 454169012696 G1 box; other site 454169012697 GEF interaction site [polypeptide binding]; other site 454169012698 GTP/Mg2+ binding site [chemical binding]; other site 454169012699 Switch I region; other site 454169012700 G2 box; other site 454169012701 G3 box; other site 454169012702 Switch II region; other site 454169012703 G4 box; other site 454169012704 G5 box; other site 454169012705 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 454169012706 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 454169012707 Antibiotic Binding Site [chemical binding]; other site 454169012708 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 454169012709 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 454169012710 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 454169012711 putative homodimer interface [polypeptide binding]; other site 454169012712 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 454169012713 heterodimer interface [polypeptide binding]; other site 454169012714 homodimer interface [polypeptide binding]; other site 454169012715 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 454169012716 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 454169012717 23S rRNA interface [nucleotide binding]; other site 454169012718 L7/L12 interface [polypeptide binding]; other site 454169012719 putative thiostrepton binding site; other site 454169012720 L25 interface [polypeptide binding]; other site 454169012721 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 454169012722 mRNA/rRNA interface [nucleotide binding]; other site 454169012723 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 454169012724 23S rRNA interface [nucleotide binding]; other site 454169012725 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 454169012726 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 454169012727 core dimer interface [polypeptide binding]; other site 454169012728 peripheral dimer interface [polypeptide binding]; other site 454169012729 L10 interface [polypeptide binding]; other site 454169012730 L11 interface [polypeptide binding]; other site 454169012731 putative EF-Tu interaction site [polypeptide binding]; other site 454169012732 putative EF-G interaction site [polypeptide binding]; other site 454169012733 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 454169012734 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 454169012735 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 454169012736 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 454169012737 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 454169012738 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 454169012739 RPB3 interaction site [polypeptide binding]; other site 454169012740 RPB1 interaction site [polypeptide binding]; other site 454169012741 RPB11 interaction site [polypeptide binding]; other site 454169012742 RPB10 interaction site [polypeptide binding]; other site 454169012743 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 454169012744 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 454169012745 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 454169012746 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 454169012747 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 454169012748 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 454169012749 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 454169012750 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 454169012751 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 454169012752 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 454169012753 DNA binding site [nucleotide binding] 454169012754 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 454169012755 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 454169012756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169012757 FeS/SAM binding site; other site 454169012758 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 454169012759 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 454169012760 ThiS interaction site; other site 454169012761 putative active site [active] 454169012762 tetramer interface [polypeptide binding]; other site 454169012763 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 454169012764 thiS-thiF/thiG interaction site; other site 454169012765 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 454169012766 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 454169012767 ATP binding site [chemical binding]; other site 454169012768 substrate interface [chemical binding]; other site 454169012769 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 454169012770 thiamine phosphate binding site [chemical binding]; other site 454169012771 active site 454169012772 pyrophosphate binding site [ion binding]; other site 454169012773 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 454169012774 ThiC-associated domain; Region: ThiC-associated; pfam13667 454169012775 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 454169012776 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 454169012777 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 454169012778 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 454169012779 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 454169012780 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 454169012781 putative NADH binding site [chemical binding]; other site 454169012782 putative active site [active] 454169012783 nudix motif; other site 454169012784 putative metal binding site [ion binding]; other site 454169012785 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 454169012786 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 454169012787 substrate binding site [chemical binding]; other site 454169012788 active site 454169012789 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 454169012790 Active_site [active] 454169012791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 454169012792 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454169012793 IHF dimer interface [polypeptide binding]; other site 454169012794 IHF - DNA interface [nucleotide binding]; other site 454169012795 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 454169012796 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454169012797 dimer interface [polypeptide binding]; other site 454169012798 sensor protein ZraS; Provisional; Region: PRK10364 454169012799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169012800 dimer interface [polypeptide binding]; other site 454169012801 phosphorylation site [posttranslational modification] 454169012802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169012803 ATP binding site [chemical binding]; other site 454169012804 Mg2+ binding site [ion binding]; other site 454169012805 G-X-G motif; other site 454169012806 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 454169012807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169012808 active site 454169012809 phosphorylation site [posttranslational modification] 454169012810 intermolecular recognition site; other site 454169012811 dimerization interface [polypeptide binding]; other site 454169012812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169012813 Walker A motif; other site 454169012814 ATP binding site [chemical binding]; other site 454169012815 Walker B motif; other site 454169012816 arginine finger; other site 454169012817 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454169012818 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 454169012819 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 454169012820 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 454169012821 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 454169012822 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 454169012823 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 454169012824 purine monophosphate binding site [chemical binding]; other site 454169012825 dimer interface [polypeptide binding]; other site 454169012826 putative catalytic residues [active] 454169012827 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 454169012828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 454169012829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169012830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 454169012831 Coenzyme A binding pocket [chemical binding]; other site 454169012832 homoserine O-succinyltransferase; Provisional; Region: PRK05368 454169012833 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 454169012834 proposed active site lysine [active] 454169012835 conserved cys residue [active] 454169012836 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 454169012837 malate synthase A; Region: malate_syn_A; TIGR01344 454169012838 active site 454169012839 isocitrate lyase; Provisional; Region: PRK15063 454169012840 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 454169012841 tetramer interface [polypeptide binding]; other site 454169012842 active site 454169012843 Mg2+/Mn2+ binding site [ion binding]; other site 454169012844 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 454169012845 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 454169012846 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 454169012847 transcriptional repressor IclR; Provisional; Region: PRK11569 454169012848 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454169012849 Bacterial transcriptional regulator; Region: IclR; pfam01614 454169012850 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 454169012851 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 454169012852 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 454169012853 substrate binding pocket [chemical binding]; other site 454169012854 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 454169012855 B12 binding site [chemical binding]; other site 454169012856 cobalt ligand [ion binding]; other site 454169012857 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 454169012858 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 454169012859 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 454169012860 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 454169012861 active site pocket [active] 454169012862 oxyanion hole [active] 454169012863 catalytic triad [active] 454169012864 active site nucleophile [active] 454169012865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 454169012866 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 454169012867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454169012868 RNA binding surface [nucleotide binding]; other site 454169012869 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 454169012870 probable active site [active] 454169012871 hypothetical protein; Provisional; Region: PRK10515 454169012872 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 454169012873 Sodium Bile acid symporter family; Region: SBF; pfam01758 454169012874 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 454169012875 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 454169012876 trimer interface [polypeptide binding]; other site 454169012877 active site 454169012878 substrate binding site [chemical binding]; other site 454169012879 CoA binding site [chemical binding]; other site 454169012880 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 454169012881 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 454169012882 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 454169012883 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 454169012884 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 454169012885 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 454169012886 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 454169012887 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 454169012888 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454169012889 Ligand binding site; other site 454169012890 Putative Catalytic site; other site 454169012891 DXD motif; other site 454169012892 Predicted membrane protein [Function unknown]; Region: COG2246 454169012893 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 454169012894 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 454169012895 Phage protein D [General function prediction only]; Region: COG3500 454169012896 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 454169012897 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 454169012898 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 454169012899 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 454169012900 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 454169012901 Phage tail tube protein FII [General function prediction only]; Region: COG3498 454169012902 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 454169012903 Gp37 protein; Region: Gp37; pfam09646 454169012904 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 454169012905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169012906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169012907 catalytic residue [active] 454169012908 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 454169012909 Mor transcription activator family; Region: Mor; pfam08765 454169012910 aspartate kinase III; Validated; Region: PRK09084 454169012911 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 454169012912 nucleotide binding site [chemical binding]; other site 454169012913 substrate binding site [chemical binding]; other site 454169012914 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 454169012915 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 454169012916 dimer interface [polypeptide binding]; other site 454169012917 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 454169012918 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 454169012919 active site 454169012920 dimer interface [polypeptide binding]; other site 454169012921 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 454169012922 dimer interface [polypeptide binding]; other site 454169012923 active site 454169012924 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 454169012925 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 454169012926 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 454169012927 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 454169012928 Predicted membrane protein [Function unknown]; Region: COG3223 454169012929 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 454169012930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169012931 dimer interface [polypeptide binding]; other site 454169012932 conserved gate region; other site 454169012933 putative PBP binding loops; other site 454169012934 ABC-ATPase subunit interface; other site 454169012935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454169012936 dimer interface [polypeptide binding]; other site 454169012937 conserved gate region; other site 454169012938 putative PBP binding loops; other site 454169012939 ABC-ATPase subunit interface; other site 454169012940 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 454169012941 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 454169012942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 454169012943 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 454169012944 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 454169012945 Walker A/P-loop; other site 454169012946 ATP binding site [chemical binding]; other site 454169012947 Q-loop/lid; other site 454169012948 ABC transporter signature motif; other site 454169012949 Walker B; other site 454169012950 D-loop; other site 454169012951 H-loop/switch region; other site 454169012952 TOBE domain; Region: TOBE_2; pfam08402 454169012953 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 454169012954 trimer interface; other site 454169012955 sugar binding site [chemical binding]; other site 454169012956 maltose regulon periplasmic protein; Provisional; Region: PRK10564 454169012957 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 454169012958 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 454169012959 UbiA prenyltransferase family; Region: UbiA; pfam01040 454169012960 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 454169012961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 454169012962 putative acyl-acceptor binding pocket; other site 454169012963 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 454169012964 LexA repressor; Validated; Region: PRK00215 454169012965 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 454169012966 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 454169012967 Catalytic site [active] 454169012968 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 454169012969 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 454169012970 hypothetical protein; Provisional; Region: PRK10428 454169012971 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 454169012972 metal binding site 2 [ion binding]; metal-binding site 454169012973 putative DNA binding helix; other site 454169012974 metal binding site 1 [ion binding]; metal-binding site 454169012975 dimer interface [polypeptide binding]; other site 454169012976 structural Zn2+ binding site [ion binding]; other site 454169012977 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 454169012978 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 454169012979 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 454169012980 FMN binding site [chemical binding]; other site 454169012981 active site 454169012982 catalytic residues [active] 454169012983 substrate binding site [chemical binding]; other site 454169012984 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 454169012985 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 454169012986 NADP binding site [chemical binding]; other site 454169012987 dimer interface [polypeptide binding]; other site 454169012988 replicative DNA helicase; Provisional; Region: PRK08006 454169012989 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 454169012990 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 454169012991 Walker A motif; other site 454169012992 ATP binding site [chemical binding]; other site 454169012993 Walker B motif; other site 454169012994 DNA binding loops [nucleotide binding] 454169012995 alanine racemase; Reviewed; Region: alr; PRK00053 454169012996 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 454169012997 active site 454169012998 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454169012999 substrate binding site [chemical binding]; other site 454169013000 catalytic residues [active] 454169013001 dimer interface [polypeptide binding]; other site 454169013002 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 454169013003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454169013004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169013005 homodimer interface [polypeptide binding]; other site 454169013006 catalytic residue [active] 454169013007 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 454169013008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169013009 active site 454169013010 motif I; other site 454169013011 motif II; other site 454169013012 Uncharacterized conserved protein [Function unknown]; Region: COG0432 454169013013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 454169013014 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 454169013015 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 454169013016 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 454169013017 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 454169013018 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 454169013019 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 454169013020 dimer interface [polypeptide binding]; other site 454169013021 ssDNA binding site [nucleotide binding]; other site 454169013022 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454169013023 hypothetical protein; Validated; Region: PRK09039 454169013024 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 454169013025 Outer membrane efflux protein; Region: OEP; pfam02321 454169013026 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 454169013027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454169013028 HlyD family secretion protein; Region: HlyD_3; pfam13437 454169013029 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169013030 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013031 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013032 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013033 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013034 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013035 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013036 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169013037 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013038 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013039 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013040 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013041 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169013042 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013043 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013044 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169013045 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013046 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013047 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013048 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013049 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169013050 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013051 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013052 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013053 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013054 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013055 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013056 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454169013057 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013058 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013059 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013060 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013061 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013062 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013063 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454169013064 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013065 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 454169013066 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013067 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013068 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454169013069 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 454169013070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169013071 Walker A/P-loop; other site 454169013072 ATP binding site [chemical binding]; other site 454169013073 Q-loop/lid; other site 454169013074 ABC transporter signature motif; other site 454169013075 Walker B; other site 454169013076 D-loop; other site 454169013077 H-loop/switch region; other site 454169013078 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 454169013079 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454169013080 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454169013081 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 454169013082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169013083 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 454169013084 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 454169013085 DNA binding residues [nucleotide binding] 454169013086 dimer interface [polypeptide binding]; other site 454169013087 [2Fe-2S] cluster binding site [ion binding]; other site 454169013088 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 454169013089 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 454169013090 putative C-terminal domain interface [polypeptide binding]; other site 454169013091 putative GSH binding site (G-site) [chemical binding]; other site 454169013092 putative dimer interface [polypeptide binding]; other site 454169013093 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 454169013094 putative N-terminal domain interface [polypeptide binding]; other site 454169013095 putative dimer interface [polypeptide binding]; other site 454169013096 putative substrate binding pocket (H-site) [chemical binding]; other site 454169013097 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 454169013098 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 454169013099 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 454169013100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454169013101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169013102 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 454169013103 putative dimerization interface [polypeptide binding]; other site 454169013104 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 454169013105 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 454169013106 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 454169013107 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 454169013108 Na binding site [ion binding]; other site 454169013109 Predicted membrane protein [Function unknown]; Region: COG3162 454169013110 acetyl-CoA synthetase; Provisional; Region: PRK00174 454169013111 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 454169013112 active site 454169013113 CoA binding site [chemical binding]; other site 454169013114 acyl-activating enzyme (AAE) consensus motif; other site 454169013115 AMP binding site [chemical binding]; other site 454169013116 acetate binding site [chemical binding]; other site 454169013117 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 454169013118 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 454169013119 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 454169013120 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 454169013121 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 454169013122 heme lyase subunit NrfE; Provisional; Region: PRK10369 454169013123 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 454169013124 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 454169013125 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 454169013126 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454169013127 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454169013128 Sel1-like repeats; Region: SEL1; smart00671 454169013129 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 454169013130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169013131 Coenzyme A binding pocket [chemical binding]; other site 454169013132 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 454169013133 dimer interface [polypeptide binding]; other site 454169013134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454169013135 hypothetical protein; Provisional; Region: PRK10220 454169013136 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 454169013137 PhnA protein; Region: PhnA; pfam03831 454169013138 proline/glycine betaine transporter; Provisional; Region: PRK10642 454169013139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169013140 putative substrate translocation pore; other site 454169013141 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 454169013142 sensor protein BasS/PmrB; Provisional; Region: PRK10755 454169013143 HAMP domain; Region: HAMP; pfam00672 454169013144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169013145 dimer interface [polypeptide binding]; other site 454169013146 phosphorylation site [posttranslational modification] 454169013147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169013148 ATP binding site [chemical binding]; other site 454169013149 Mg2+ binding site [ion binding]; other site 454169013150 G-X-G motif; other site 454169013151 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 454169013152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169013153 active site 454169013154 phosphorylation site [posttranslational modification] 454169013155 intermolecular recognition site; other site 454169013156 dimerization interface [polypeptide binding]; other site 454169013157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169013158 DNA binding site [nucleotide binding] 454169013159 putative metal dependent hydrolase; Provisional; Region: PRK11598 454169013160 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 454169013161 Sulfatase; Region: Sulfatase; pfam00884 454169013162 arginine:agmatin antiporter; Provisional; Region: PRK10644 454169013163 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 454169013164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169013165 arginine decarboxylase; Provisional; Region: PRK15029 454169013166 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454169013167 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454169013168 homodimer interface [polypeptide binding]; other site 454169013169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454169013170 catalytic residue [active] 454169013171 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454169013172 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 454169013173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169013174 alpha-galactosidase; Provisional; Region: PRK15076 454169013175 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 454169013176 NAD binding site [chemical binding]; other site 454169013177 sugar binding site [chemical binding]; other site 454169013178 divalent metal binding site [ion binding]; other site 454169013179 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 454169013180 dimer interface [polypeptide binding]; other site 454169013181 melibiose:sodium symporter; Provisional; Region: PRK10429 454169013182 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 454169013183 fumarate hydratase; Provisional; Region: PRK15389 454169013184 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 454169013185 Fumarase C-terminus; Region: Fumerase_C; pfam05683 454169013186 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 454169013187 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 454169013188 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 454169013189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169013190 active site 454169013191 phosphorylation site [posttranslational modification] 454169013192 intermolecular recognition site; other site 454169013193 dimerization interface [polypeptide binding]; other site 454169013194 sensory histidine kinase DcuS; Provisional; Region: PRK11086 454169013195 PAS domain; Region: PAS; smart00091 454169013196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169013197 ATP binding site [chemical binding]; other site 454169013198 Mg2+ binding site [ion binding]; other site 454169013199 G-X-G motif; other site 454169013200 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454169013201 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454169013202 putative [Fe4-S4] binding site [ion binding]; other site 454169013203 putative molybdopterin cofactor binding site [chemical binding]; other site 454169013204 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454169013205 putative molybdopterin cofactor binding site; other site 454169013206 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454169013207 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 454169013208 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 454169013209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 454169013210 SdiA-regulated; Region: SdiA-regulated; cd09971 454169013211 putative active site [active] 454169013212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454169013213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169013214 DNA binding residues [nucleotide binding] 454169013215 dimerization interface [polypeptide binding]; other site 454169013216 AraC family transcriptional regulator; Provisional; Region: PRK15186 454169013217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169013218 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 454169013219 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454169013220 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 454169013221 active site 454169013222 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 454169013223 Methyltransferase domain; Region: Methyltransf_27; pfam13708 454169013224 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 454169013225 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 454169013226 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 454169013227 Protein of unknown function (DUF987); Region: DUF987; pfam06174 454169013228 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 454169013229 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 454169013230 MPN+ (JAMM) motif; other site 454169013231 Zinc-binding site [ion binding]; other site 454169013232 Antirestriction protein; Region: Antirestrict; pfam03230 454169013233 Domain of unknown function (DUF932); Region: DUF932; pfam06067 454169013234 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 454169013235 Predicted GTPase [General function prediction only]; Region: COG3596 454169013236 YfjP GTPase; Region: YfjP; cd11383 454169013237 G1 box; other site 454169013238 GTP/Mg2+ binding site [chemical binding]; other site 454169013239 Switch I region; other site 454169013240 G2 box; other site 454169013241 Switch II region; other site 454169013242 G3 box; other site 454169013243 G4 box; other site 454169013244 G5 box; other site 454169013245 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 454169013246 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 454169013247 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 454169013248 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 454169013249 ProQ/FINO family; Region: ProQ; pfam04352 454169013250 H-NS histone family; Region: Histone_HNS; pfam00816 454169013251 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 454169013252 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 454169013253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454169013254 Zn2+ binding site [ion binding]; other site 454169013255 Mg2+ binding site [ion binding]; other site 454169013256 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 454169013257 putative transposase OrfB; Reviewed; Region: PHA02517 454169013258 HTH-like domain; Region: HTH_21; pfam13276 454169013259 Integrase core domain; Region: rve; pfam00665 454169013260 Integrase core domain; Region: rve_2; pfam13333 454169013261 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 454169013262 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 454169013263 dimerization interface [polypeptide binding]; other site 454169013264 active site 454169013265 Transposase domain (DUF772); Region: DUF772; pfam05598 454169013266 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169013267 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169013268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169013269 non-specific DNA binding site [nucleotide binding]; other site 454169013270 salt bridge; other site 454169013271 sequence-specific DNA binding site [nucleotide binding]; other site 454169013272 Domain of unknown function (DUF955); Region: DUF955; pfam06114 454169013273 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 454169013274 homodimer interface [polypeptide binding]; other site 454169013275 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 454169013276 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 454169013277 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 454169013278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169013279 ATP binding site [chemical binding]; other site 454169013280 putative Mg++ binding site [ion binding]; other site 454169013281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 454169013282 HsdM N-terminal domain; Region: HsdM_N; pfam12161 454169013283 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 454169013284 Methyltransferase domain; Region: Methyltransf_26; pfam13659 454169013285 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 454169013286 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 454169013287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454169013288 AAA domain; Region: AAA_21; pfam13304 454169013289 Walker A/P-loop; other site 454169013290 ATP binding site [chemical binding]; other site 454169013291 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454169013292 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 454169013293 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 454169013294 Transposase; Region: HTH_Tnp_1; cl17663 454169013295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 454169013296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454169013297 dimerization interface [polypeptide binding]; other site 454169013298 putative DNA binding site [nucleotide binding]; other site 454169013299 putative Zn2+ binding site [ion binding]; other site 454169013300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169013301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454169013302 putative substrate translocation pore; other site 454169013303 Transposase domain (DUF772); Region: DUF772; pfam05598 454169013304 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 454169013305 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 454169013306 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 454169013307 Predicted transcriptional regulator [Transcription]; Region: COG2378 454169013308 WYL domain; Region: WYL; pfam13280 454169013309 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 454169013310 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 454169013311 Sulfatase; Region: Sulfatase; pfam00884 454169013312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 454169013313 TPR motif; other site 454169013314 binding surface 454169013315 integrase; Provisional; Region: PRK09692 454169013316 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 454169013317 active site 454169013318 Int/Topo IB signature motif; other site 454169013319 putative transcriptional regulator; Provisional; Region: PRK11640 454169013320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454169013321 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 454169013322 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 454169013323 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 454169013324 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 454169013325 DsbD alpha interface [polypeptide binding]; other site 454169013326 catalytic residues [active] 454169013327 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 454169013328 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 454169013329 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 454169013330 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 454169013331 Aspartase; Region: Aspartase; cd01357 454169013332 active sites [active] 454169013333 tetramer interface [polypeptide binding]; other site 454169013334 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 454169013335 putative transporter; Provisional; Region: PRK11021 454169013336 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 454169013337 oligomerisation interface [polypeptide binding]; other site 454169013338 mobile loop; other site 454169013339 roof hairpin; other site 454169013340 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 454169013341 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 454169013342 ring oligomerisation interface [polypeptide binding]; other site 454169013343 ATP/Mg binding site [chemical binding]; other site 454169013344 stacking interactions; other site 454169013345 hinge regions; other site 454169013346 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 454169013347 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 454169013348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169013349 FeS/SAM binding site; other site 454169013350 elongation factor P; Validated; Region: PRK00529 454169013351 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 454169013352 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 454169013353 RNA binding site [nucleotide binding]; other site 454169013354 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 454169013355 RNA binding site [nucleotide binding]; other site 454169013356 Predicted small secreted protein [Function unknown]; Region: COG5510 454169013357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454169013358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169013359 DNA binding residues [nucleotide binding] 454169013360 dimerization interface [polypeptide binding]; other site 454169013361 multidrug efflux system protein; Provisional; Region: PRK11431 454169013362 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 454169013363 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 454169013364 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 454169013365 Iron-sulfur protein interface; other site 454169013366 proximal quinone binding site [chemical binding]; other site 454169013367 C-subunit interface; other site 454169013368 distal quinone binding site; other site 454169013369 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 454169013370 D-subunit interface [polypeptide binding]; other site 454169013371 Iron-sulfur protein interface; other site 454169013372 proximal quinone binding site [chemical binding]; other site 454169013373 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 454169013374 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 454169013375 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 454169013376 L-aspartate oxidase; Provisional; Region: PRK06175 454169013377 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 454169013378 poxB regulator PoxA; Provisional; Region: PRK09350 454169013379 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 454169013380 motif 1; other site 454169013381 dimer interface [polypeptide binding]; other site 454169013382 active site 454169013383 motif 2; other site 454169013384 motif 3; other site 454169013385 inner membrane transporter YjeM; Provisional; Region: PRK15238 454169013386 putative mechanosensitive channel protein; Provisional; Region: PRK10929 454169013387 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 454169013388 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454169013389 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 454169013390 GTPase RsgA; Reviewed; Region: PRK12288 454169013391 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 454169013392 RNA binding site [nucleotide binding]; other site 454169013393 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 454169013394 GTPase/Zn-binding domain interface [polypeptide binding]; other site 454169013395 GTP/Mg2+ binding site [chemical binding]; other site 454169013396 G4 box; other site 454169013397 G5 box; other site 454169013398 G1 box; other site 454169013399 Switch I region; other site 454169013400 G2 box; other site 454169013401 G3 box; other site 454169013402 Switch II region; other site 454169013403 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 454169013404 catalytic site [active] 454169013405 putative active site [active] 454169013406 putative substrate binding site [chemical binding]; other site 454169013407 dimer interface [polypeptide binding]; other site 454169013408 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 454169013409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454169013410 substrate binding pocket [chemical binding]; other site 454169013411 membrane-bound complex binding site; other site 454169013412 hinge residues; other site 454169013413 epoxyqueuosine reductase; Region: TIGR00276 454169013414 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 454169013415 putative carbohydrate kinase; Provisional; Region: PRK10565 454169013416 Uncharacterized conserved protein [Function unknown]; Region: COG0062 454169013417 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 454169013418 putative substrate binding site [chemical binding]; other site 454169013419 putative ATP binding site [chemical binding]; other site 454169013420 ADP-binding protein; Provisional; Region: PRK10646 454169013421 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 454169013422 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 454169013423 active site 454169013424 metal binding site [ion binding]; metal-binding site 454169013425 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 454169013426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169013427 ATP binding site [chemical binding]; other site 454169013428 Mg2+ binding site [ion binding]; other site 454169013429 G-X-G motif; other site 454169013430 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 454169013431 ATP binding site [chemical binding]; other site 454169013432 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 454169013433 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 454169013434 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 454169013435 bacterial Hfq-like; Region: Hfq; cd01716 454169013436 hexamer interface [polypeptide binding]; other site 454169013437 Sm1 motif; other site 454169013438 RNA binding site [nucleotide binding]; other site 454169013439 Sm2 motif; other site 454169013440 GTPase HflX; Provisional; Region: PRK11058 454169013441 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 454169013442 HflX GTPase family; Region: HflX; cd01878 454169013443 G1 box; other site 454169013444 GTP/Mg2+ binding site [chemical binding]; other site 454169013445 Switch I region; other site 454169013446 G2 box; other site 454169013447 G3 box; other site 454169013448 Switch II region; other site 454169013449 G4 box; other site 454169013450 G5 box; other site 454169013451 FtsH protease regulator HflK; Provisional; Region: PRK10930 454169013452 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 454169013453 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 454169013454 FtsH protease regulator HflC; Provisional; Region: PRK11029 454169013455 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 454169013456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 454169013457 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 454169013458 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 454169013459 GDP-binding site [chemical binding]; other site 454169013460 ACT binding site; other site 454169013461 IMP binding site; other site 454169013462 Predicted transcriptional regulator [Transcription]; Region: COG1959 454169013463 transcriptional repressor NsrR; Provisional; Region: PRK11014 454169013464 exoribonuclease R; Provisional; Region: PRK11642 454169013465 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 454169013466 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 454169013467 RNB domain; Region: RNB; pfam00773 454169013468 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 454169013469 RNA binding site [nucleotide binding]; other site 454169013470 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 454169013471 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 454169013472 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 454169013473 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 454169013474 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 454169013475 Ion channel; Region: Ion_trans_2; pfam07885 454169013476 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 454169013477 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 454169013478 Predicted membrane protein [Function unknown]; Region: COG3766 454169013479 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 454169013480 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 454169013481 Predicted integral membrane protein [Function unknown]; Region: COG5463 454169013482 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 454169013483 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 454169013484 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 454169013485 FAD binding site [chemical binding]; other site 454169013486 substrate binding site [chemical binding]; other site 454169013487 catalytic residues [active] 454169013488 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454169013489 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 454169013490 esterase; Provisional; Region: PRK10566 454169013491 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 454169013492 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454169013493 transcriptional repressor UlaR; Provisional; Region: PRK13509 454169013494 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454169013495 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454169013496 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 454169013497 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 454169013498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 454169013499 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 454169013500 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 454169013501 active site 454169013502 P-loop; other site 454169013503 phosphorylation site [posttranslational modification] 454169013504 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169013505 active site 454169013506 phosphorylation site [posttranslational modification] 454169013507 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 454169013508 active site 454169013509 dimer interface [polypeptide binding]; other site 454169013510 magnesium binding site [ion binding]; other site 454169013511 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 454169013512 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 454169013513 AP (apurinic/apyrimidinic) site pocket; other site 454169013514 DNA interaction; other site 454169013515 Metal-binding active site; metal-binding site 454169013516 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454169013517 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454169013518 intersubunit interface [polypeptide binding]; other site 454169013519 active site 454169013520 Zn2+ binding site [ion binding]; other site 454169013521 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 454169013522 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 454169013523 dimer interface [polypeptide binding]; other site 454169013524 ssDNA binding site [nucleotide binding]; other site 454169013525 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454169013526 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 454169013527 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 454169013528 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 454169013529 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 454169013530 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454169013531 EamA-like transporter family; Region: EamA; pfam00892 454169013532 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 454169013533 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 454169013534 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 454169013535 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 454169013536 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454169013537 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 454169013538 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 454169013539 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 454169013540 Hemerythrin-like domain; Region: Hr-like; cd12108 454169013541 Fe binding site [ion binding]; other site 454169013542 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454169013543 EamA-like transporter family; Region: EamA; pfam00892 454169013544 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 454169013545 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 454169013546 NADP binding site [chemical binding]; other site 454169013547 Predicted transcriptional regulators [Transcription]; Region: COG1733 454169013548 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 454169013549 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 454169013550 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 454169013551 active site 454169013552 metal binding site [ion binding]; metal-binding site 454169013553 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454169013554 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 454169013555 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 454169013556 active site 454169013557 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 454169013558 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 454169013559 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 454169013560 Domain of unknown function DUF21; Region: DUF21; pfam01595 454169013561 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454169013562 Transporter associated domain; Region: CorC_HlyC; smart01091 454169013563 methionine sulfoxide reductase A; Provisional; Region: PRK00058 454169013564 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 454169013565 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454169013566 Surface antigen; Region: Bac_surface_Ag; pfam01103 454169013567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 454169013568 Family of unknown function (DUF490); Region: DUF490; pfam04357 454169013569 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 454169013570 putative active site pocket [active] 454169013571 dimerization interface [polypeptide binding]; other site 454169013572 putative catalytic residue [active] 454169013573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169013574 D-galactonate transporter; Region: 2A0114; TIGR00893 454169013575 putative substrate translocation pore; other site 454169013576 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 454169013577 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 454169013578 active site 454169013579 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 454169013580 dimer interface [polypeptide binding]; other site 454169013581 substrate binding site [chemical binding]; other site 454169013582 metal binding sites [ion binding]; metal-binding site 454169013583 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 454169013584 AMP binding site [chemical binding]; other site 454169013585 metal binding site [ion binding]; metal-binding site 454169013586 active site 454169013587 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 454169013588 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454169013589 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454169013590 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454169013591 hypothetical protein; Provisional; Region: PRK05255 454169013592 peptidase PmbA; Provisional; Region: PRK11040 454169013593 cytochrome b562; Provisional; Region: PRK15058 454169013594 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 454169013595 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 454169013596 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 454169013597 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 454169013598 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 454169013599 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 454169013600 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 454169013601 active site 454169013602 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 454169013603 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 454169013604 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 454169013605 HTH domain; Region: HTH_11; pfam08279 454169013606 Mga helix-turn-helix domain; Region: Mga; pfam05043 454169013607 PRD domain; Region: PRD; pfam00874 454169013608 PRD domain; Region: PRD; pfam00874 454169013609 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 454169013610 active site 454169013611 P-loop; other site 454169013612 phosphorylation site [posttranslational modification] 454169013613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454169013614 active site 454169013615 phosphorylation site [posttranslational modification] 454169013616 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 454169013617 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 454169013618 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 454169013619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169013620 FeS/SAM binding site; other site 454169013621 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 454169013622 ATP cone domain; Region: ATP-cone; pfam03477 454169013623 Class III ribonucleotide reductase; Region: RNR_III; cd01675 454169013624 effector binding site; other site 454169013625 active site 454169013626 Zn binding site [ion binding]; other site 454169013627 glycine loop; other site 454169013628 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 454169013629 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 454169013630 Ca binding site [ion binding]; other site 454169013631 active site 454169013632 catalytic site [active] 454169013633 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 454169013634 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 454169013635 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454169013636 active site turn [active] 454169013637 phosphorylation site [posttranslational modification] 454169013638 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454169013639 trehalose repressor; Provisional; Region: treR; PRK09492 454169013640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169013641 DNA binding site [nucleotide binding] 454169013642 domain linker motif; other site 454169013643 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 454169013644 dimerization interface [polypeptide binding]; other site 454169013645 ligand binding site [chemical binding]; other site 454169013646 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 454169013647 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 454169013648 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454169013649 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 454169013650 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 454169013651 Soluble P-type ATPase [General function prediction only]; Region: COG4087 454169013652 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 454169013653 Transposase; Region: HTH_Tnp_1; cl17663 454169013654 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 454169013655 homotrimer interaction site [polypeptide binding]; other site 454169013656 putative active site [active] 454169013657 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 454169013658 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 454169013659 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 454169013660 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 454169013661 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 454169013662 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 454169013663 Arginine repressor [Transcription]; Region: ArgR; COG1438 454169013664 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 454169013665 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 454169013666 Predicted membrane protein [Function unknown]; Region: COG1288 454169013667 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 454169013668 ornithine carbamoyltransferase; Validated; Region: PRK02102 454169013669 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 454169013670 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 454169013671 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 454169013672 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 454169013673 putative substrate binding site [chemical binding]; other site 454169013674 nucleotide binding site [chemical binding]; other site 454169013675 nucleotide binding site [chemical binding]; other site 454169013676 homodimer interface [polypeptide binding]; other site 454169013677 arginine deiminase; Provisional; Region: PRK01388 454169013678 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454169013679 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 454169013680 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 454169013681 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 454169013682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 454169013683 RNase E inhibitor protein; Provisional; Region: PRK11191 454169013684 Transposase IS200 like; Region: Y1_Tnp; pfam01797 454169013685 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 454169013686 active site 454169013687 dinuclear metal binding site [ion binding]; other site 454169013688 dimerization interface [polypeptide binding]; other site 454169013689 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 454169013690 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 454169013691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169013692 Coenzyme A binding pocket [chemical binding]; other site 454169013693 Predicted membrane protein [Function unknown]; Region: COG4269 454169013694 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 454169013695 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 454169013696 HIGH motif; other site 454169013697 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 454169013698 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 454169013699 active site 454169013700 KMSKS motif; other site 454169013701 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 454169013702 tRNA binding surface [nucleotide binding]; other site 454169013703 anticodon binding site; other site 454169013704 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 454169013705 DNA polymerase III subunit chi; Validated; Region: PRK05728 454169013706 multifunctional aminopeptidase A; Provisional; Region: PRK00913 454169013707 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 454169013708 interface (dimer of trimers) [polypeptide binding]; other site 454169013709 Substrate-binding/catalytic site; other site 454169013710 Zn-binding sites [ion binding]; other site 454169013711 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 454169013712 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 454169013713 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 454169013714 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 454169013715 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 454169013716 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454169013717 DNA binding site [nucleotide binding] 454169013718 domain linker motif; other site 454169013719 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454169013720 putative dimerization interface [polypeptide binding]; other site 454169013721 putative ligand binding site [chemical binding]; other site 454169013722 gluconate transporter; Region: gntP; TIGR00791 454169013723 fructuronate transporter; Provisional; Region: PRK10034; cl15264 454169013724 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 454169013725 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 454169013726 NADP binding site [chemical binding]; other site 454169013727 homodimer interface [polypeptide binding]; other site 454169013728 active site 454169013729 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 454169013730 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 454169013731 putative NAD(P) binding site [chemical binding]; other site 454169013732 catalytic Zn binding site [ion binding]; other site 454169013733 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 454169013734 ATP-binding site [chemical binding]; other site 454169013735 Gluconate-6-phosphate binding site [chemical binding]; other site 454169013736 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 454169013737 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 454169013738 putative NAD(P) binding site [chemical binding]; other site 454169013739 putative substrate binding site [chemical binding]; other site 454169013740 catalytic Zn binding site [ion binding]; other site 454169013741 structural Zn binding site [ion binding]; other site 454169013742 dimer interface [polypeptide binding]; other site 454169013743 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 454169013744 HNH endonuclease; Region: HNH_2; pfam13391 454169013745 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 454169013746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169013747 ATP binding site [chemical binding]; other site 454169013748 putative Mg++ binding site [ion binding]; other site 454169013749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169013750 nucleotide binding region [chemical binding]; other site 454169013751 ATP-binding site [chemical binding]; other site 454169013752 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 454169013753 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 454169013754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169013755 ATP binding site [chemical binding]; other site 454169013756 putative Mg++ binding site [ion binding]; other site 454169013757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454169013758 ATP-binding site [chemical binding]; other site 454169013759 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 454169013760 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 454169013761 Part of AAA domain; Region: AAA_19; pfam13245 454169013762 Family description; Region: UvrD_C_2; pfam13538 454169013763 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 454169013764 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 454169013765 dimer interface [polypeptide binding]; other site 454169013766 Mn binding site [ion binding]; other site 454169013767 K binding site [ion binding]; other site 454169013768 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 454169013769 HNH endonuclease; Region: HNH_2; pfam13391 454169013770 hypothetical protein; Provisional; Region: PRK12378 454169013771 Methyltransferase domain; Region: Methyltransf_23; pfam13489 454169013772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169013773 S-adenosylmethionine binding site [chemical binding]; other site 454169013774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169013775 S-adenosylmethionine binding site [chemical binding]; other site 454169013776 hypothetical protein; Provisional; Region: PRK13687 454169013777 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 454169013778 Protein of unknown function DUF91; Region: DUF91; cl00709 454169013779 Uncharacterized conserved protein [Function unknown]; Region: COG3439 454169013780 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 454169013781 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 454169013782 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 454169013783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454169013784 DNA-binding site [nucleotide binding]; DNA binding site 454169013785 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454169013786 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 454169013787 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 454169013788 active site 454169013789 HIGH motif; other site 454169013790 dimer interface [polypeptide binding]; other site 454169013791 KMSKS motif; other site 454169013792 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 454169013793 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 454169013794 aspartate racemase; Region: asp_race; TIGR00035 454169013795 cell density-dependent motility repressor; Provisional; Region: PRK10082 454169013796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454169013797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454169013798 dimerization interface [polypeptide binding]; other site 454169013799 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 454169013800 isoaspartyl dipeptidase; Provisional; Region: PRK10657 454169013801 dimer interface [polypeptide binding]; other site 454169013802 active site 454169013803 hypothetical protein; Provisional; Region: PRK10519 454169013804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 454169013805 Nucleoside recognition; Region: Gate; pfam07670 454169013806 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 454169013807 Predicted membrane protein [Function unknown]; Region: COG2733 454169013808 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 454169013809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454169013810 putative substrate translocation pore; other site 454169013811 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454169013812 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 454169013813 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 454169013814 NAD(P) binding site [chemical binding]; other site 454169013815 catalytic residues [active] 454169013816 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 454169013817 endoribonuclease SymE; Provisional; Region: PRK13605 454169013818 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 454169013819 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 454169013820 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 454169013821 HsdM N-terminal domain; Region: HsdM_N; pfam12161 454169013822 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 454169013823 Methyltransferase domain; Region: Methyltransf_26; pfam13659 454169013824 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 454169013825 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 454169013826 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 454169013827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454169013828 ATP binding site [chemical binding]; other site 454169013829 putative Mg++ binding site [ion binding]; other site 454169013830 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 454169013831 Mrr N-terminal domain; Region: Mrr_N; pfam14338 454169013832 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 454169013833 Restriction endonuclease; Region: Mrr_cat; pfam04471 454169013834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 454169013835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 454169013836 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 454169013837 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 454169013838 P-loop, Walker A motif; other site 454169013839 Base recognition motif; other site 454169013840 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 454169013841 Uncharacterized small protein [Function unknown]; Region: COG2879 454169013842 carbon starvation protein A; Provisional; Region: PRK15015 454169013843 Carbon starvation protein CstA; Region: CstA; pfam02554 454169013844 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 454169013845 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 454169013846 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454169013847 dimer interface [polypeptide binding]; other site 454169013848 ligand binding site [chemical binding]; other site 454169013849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454169013850 dimerization interface [polypeptide binding]; other site 454169013851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454169013852 dimer interface [polypeptide binding]; other site 454169013853 putative CheW interface [polypeptide binding]; other site 454169013854 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454169013855 active pocket/dimerization site; other site 454169013856 active site 454169013857 phosphorylation site [posttranslational modification] 454169013858 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 454169013859 active site 454169013860 phosphorylation site [posttranslational modification] 454169013861 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 454169013862 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 454169013863 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 454169013864 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 454169013865 dimer interface [polypeptide binding]; other site 454169013866 active site 454169013867 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454169013868 dimer interface [polypeptide binding]; other site 454169013869 active site 454169013870 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 454169013871 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 454169013872 putative active site [active] 454169013873 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 454169013874 phosphoglycerol transferase I; Provisional; Region: PRK03776 454169013875 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 454169013876 hypothetical protein; Provisional; Region: PRK11667 454169013877 DNA replication protein DnaC; Validated; Region: PRK07952 454169013878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454169013879 Walker A motif; other site 454169013880 ATP binding site [chemical binding]; other site 454169013881 Walker B motif; other site 454169013882 primosomal protein DnaI; Provisional; Region: PRK02854 454169013883 hypothetical protein; Provisional; Region: PRK09917 454169013884 Uncharacterized conserved protein [Function unknown]; Region: COG2966 454169013885 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 454169013886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454169013887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169013888 DNA binding residues [nucleotide binding] 454169013889 dimerization interface [polypeptide binding]; other site 454169013890 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 454169013891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454169013892 DNA binding residues [nucleotide binding] 454169013893 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 454169013894 putative deacylase active site [active] 454169013895 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 454169013896 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 454169013897 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 454169013898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454169013899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454169013900 metal binding site [ion binding]; metal-binding site 454169013901 active site 454169013902 I-site; other site 454169013903 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 454169013904 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 454169013905 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 454169013906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454169013907 S-adenosylmethionine binding site [chemical binding]; other site 454169013908 DNA polymerase III subunit psi; Validated; Region: PRK06856 454169013909 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 454169013910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454169013911 Coenzyme A binding pocket [chemical binding]; other site 454169013912 dUMP phosphatase; Provisional; Region: PRK09449 454169013913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169013914 motif II; other site 454169013915 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 454169013916 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 454169013917 G1 box; other site 454169013918 putative GEF interaction site [polypeptide binding]; other site 454169013919 GTP/Mg2+ binding site [chemical binding]; other site 454169013920 Switch I region; other site 454169013921 G2 box; other site 454169013922 G3 box; other site 454169013923 Switch II region; other site 454169013924 G4 box; other site 454169013925 G5 box; other site 454169013926 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 454169013927 periplasmic protein; Provisional; Region: PRK10568 454169013928 BON domain; Region: BON; pfam04972 454169013929 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 454169013930 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 454169013931 active site 454169013932 nucleophile elbow; other site 454169013933 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 454169013934 active site 454169013935 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 454169013936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454169013937 FeS/SAM binding site; other site 454169013938 hypothetical protein; Provisional; Region: PRK10977 454169013939 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 454169013940 intersubunit interface [polypeptide binding]; other site 454169013941 active site 454169013942 catalytic residue [active] 454169013943 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 454169013944 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 454169013945 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 454169013946 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 454169013947 phosphopentomutase; Provisional; Region: PRK05362 454169013948 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 454169013949 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 454169013950 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 454169013951 hypothetical protein; Provisional; Region: PRK15301 454169013952 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 454169013953 PapC N-terminal domain; Region: PapC_N; pfam13954 454169013954 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169013955 PapC C-terminal domain; Region: PapC_C; pfam13953 454169013956 putative fimbrial chaperone protein; Provisional; Region: PRK09918 454169013957 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169013958 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169013959 hypothetical protein; Provisional; Region: PRK15302 454169013960 hypothetical protein; Provisional; Region: PRK15303 454169013961 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 454169013962 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 454169013963 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 454169013964 hypothetical protein; Provisional; Region: PRK11246 454169013965 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 454169013966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454169013967 motif II; other site 454169013968 DNA repair protein RadA; Region: sms; TIGR00416 454169013969 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 454169013970 Walker A motif/ATP binding site; other site 454169013971 ATP binding site [chemical binding]; other site 454169013972 Walker B motif; other site 454169013973 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 454169013974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454169013975 non-specific DNA binding site [nucleotide binding]; other site 454169013976 salt bridge; other site 454169013977 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 454169013978 sequence-specific DNA binding site [nucleotide binding]; other site 454169013979 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 454169013980 active site 454169013981 (T/H)XGH motif; other site 454169013982 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 454169013983 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 454169013984 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169013985 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169013986 ABC transporter; Region: ABC_tran_2; pfam12848 454169013987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454169013988 lytic murein transglycosylase; Provisional; Region: PRK11619 454169013989 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454169013990 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454169013991 catalytic residue [active] 454169013992 Trp operon repressor; Provisional; Region: PRK01381 454169013993 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 454169013994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454169013995 catalytic core [active] 454169013996 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 454169013997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454169013998 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 454169013999 hypothetical protein; Provisional; Region: PRK10756 454169014000 CreA protein; Region: CreA; pfam05981 454169014001 DNA-binding response regulator CreB; Provisional; Region: PRK11083 454169014002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169014003 active site 454169014004 phosphorylation site [posttranslational modification] 454169014005 intermolecular recognition site; other site 454169014006 dimerization interface [polypeptide binding]; other site 454169014007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169014008 DNA binding site [nucleotide binding] 454169014009 sensory histidine kinase CreC; Provisional; Region: PRK11100 454169014010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 454169014011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454169014012 dimer interface [polypeptide binding]; other site 454169014013 phosphorylation site [posttranslational modification] 454169014014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454169014015 ATP binding site [chemical binding]; other site 454169014016 Mg2+ binding site [ion binding]; other site 454169014017 G-X-G motif; other site 454169014018 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 454169014019 putative major fimbrial protein SthE; Provisional; Region: PRK15292 454169014020 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 454169014021 putative fimbrial protein SthD; Provisional; Region: PRK15293 454169014022 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 454169014023 PapC N-terminal domain; Region: PapC_N; pfam13954 454169014024 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454169014025 PapC C-terminal domain; Region: PapC_C; pfam13953 454169014026 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 454169014027 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454169014028 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454169014029 putative fimbrial protein SthA; Provisional; Region: PRK15296 454169014030 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 454169014031 Helix-turn-helix domain; Region: HTH_36; pfam13730 454169014032 two-component response regulator; Provisional; Region: PRK11173 454169014033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454169014034 active site 454169014035 phosphorylation site [posttranslational modification] 454169014036 intermolecular recognition site; other site 454169014037 dimerization interface [polypeptide binding]; other site 454169014038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454169014039 DNA binding site [nucleotide binding] 454169014040 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 454169014041 putative RNA methyltransferase; Provisional; Region: PRK10433