-- dump date 20140620_053950 -- class Genbank::misc_feature -- table misc_feature_note -- id note 423368000001 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 423368000002 Ligand Binding Site [chemical binding]; other site 423368000003 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 423368000004 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 423368000005 tandem repeat interface [polypeptide binding]; other site 423368000006 oligomer interface [polypeptide binding]; other site 423368000007 active site residues [active] 423368000008 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 423368000009 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 423368000010 catalytic residues [active] 423368000011 Staphylococcal nuclease homologues; Region: SNc; smart00318 423368000012 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 423368000013 Catalytic site; other site 423368000014 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 423368000015 IHF dimer interface [polypeptide binding]; other site 423368000016 IHF - DNA interface [nucleotide binding]; other site 423368000017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368000018 non-specific DNA binding site [nucleotide binding]; other site 423368000019 salt bridge; other site 423368000020 sequence-specific DNA binding site [nucleotide binding]; other site 423368000021 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 423368000022 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 423368000023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 423368000024 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 423368000025 Integrase core domain; Region: rve; pfam00665 423368000026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368000027 dimerization interface [polypeptide binding]; other site 423368000028 putative DNA binding site [nucleotide binding]; other site 423368000029 putative Zn2+ binding site [ion binding]; other site 423368000030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 423368000031 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 423368000032 Integrase core domain; Region: rve; pfam00665 423368000033 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 423368000034 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 423368000035 catalytic residues [active] 423368000036 catalytic nucleophile [active] 423368000037 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 423368000038 Putative transposase; Region: Y2_Tnp; pfam04986 423368000039 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 423368000040 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 423368000041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368000042 putative substrate translocation pore; other site 423368000043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368000044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368000045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368000046 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368000047 putative substrate translocation pore; other site 423368000048 tetracycline repressor protein TetR; Provisional; Region: PRK13756 423368000049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368000050 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 423368000051 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 423368000052 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 423368000053 Phosphotransferase enzyme family; Region: APH; pfam01636 423368000054 active site 423368000055 ATP binding site [chemical binding]; other site 423368000056 antibiotic binding site [chemical binding]; other site 423368000057 dihydropteroate synthase; Region: DHPS; TIGR01496 423368000058 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 423368000059 substrate binding pocket [chemical binding]; other site 423368000060 dimer interface [polypeptide binding]; other site 423368000061 inhibitor binding site; inhibition site 423368000062 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 423368000063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 423368000064 P-loop; other site 423368000065 Magnesium ion binding site [ion binding]; other site 423368000066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 423368000067 Magnesium ion binding site [ion binding]; other site 423368000068 ParB-like nuclease domain; Region: ParB; smart00470 423368000069 KorB domain; Region: KorB; pfam08535 423368000070 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 423368000071 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 423368000072 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 423368000073 DNA topoisomerase III; Provisional; Region: PRK07726 423368000074 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 423368000075 active site 423368000076 putative interdomain interaction site [polypeptide binding]; other site 423368000077 putative metal-binding site [ion binding]; other site 423368000078 putative nucleotide binding site [chemical binding]; other site 423368000079 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 423368000080 domain I; other site 423368000081 DNA binding groove [nucleotide binding] 423368000082 phosphate binding site [ion binding]; other site 423368000083 domain II; other site 423368000084 domain III; other site 423368000085 nucleotide binding site [chemical binding]; other site 423368000086 catalytic site [active] 423368000087 domain IV; other site 423368000088 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368000089 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368000090 Putative helicase; Region: TraI_2; pfam07514 423368000091 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 423368000092 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 423368000093 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 423368000094 cellulose synthase-like protein; Region: PLN02248 423368000095 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 423368000096 TraL protein; Region: TraL; cl06278 423368000097 TraE protein; Region: TraE; cl05060 423368000098 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 423368000099 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 423368000100 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 423368000101 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 423368000102 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 423368000103 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 423368000104 dimerization domain [polypeptide binding]; other site 423368000105 dimer interface [polypeptide binding]; other site 423368000106 catalytic residues [active] 423368000107 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 423368000108 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 423368000109 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 423368000110 multidrug efflux system protein; Provisional; Region: PRK11431 423368000111 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 423368000112 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 423368000113 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 423368000114 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 423368000115 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 423368000116 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 423368000117 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 423368000118 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 423368000119 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 423368000120 multidrug efflux system protein; Provisional; Region: PRK11431 423368000121 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 423368000122 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 423368000123 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 423368000124 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 423368000125 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 423368000126 dimerization domain [polypeptide binding]; other site 423368000127 dimer interface [polypeptide binding]; other site 423368000128 catalytic residues [active] 423368000129 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 423368000130 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 423368000131 Domain of unknown function DUF87; Region: DUF87; pfam01935 423368000132 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 423368000133 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 423368000134 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 423368000135 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 423368000136 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 423368000137 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368000138 TraU protein; Region: TraU; pfam06834 423368000139 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 423368000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368000141 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 423368000142 Walker A motif; other site 423368000143 ATP binding site [chemical binding]; other site 423368000144 Walker B motif; other site 423368000145 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 423368000146 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 423368000147 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 423368000148 dimer interface [polypeptide binding]; other site 423368000149 ssDNA binding site [nucleotide binding]; other site 423368000150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 423368000151 RecT family; Region: RecT; cl04285 423368000152 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 423368000153 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 423368000154 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 423368000155 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 423368000156 metal ion-dependent adhesion site (MIDAS); other site 423368000157 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 423368000158 Dam-replacing family; Region: DRP; pfam06044 423368000159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 423368000160 catalytic loop [active] 423368000161 iron binding site [ion binding]; other site 423368000162 Protein of unknown function (DUF475); Region: DUF475; cl17481 423368000163 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 423368000164 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 423368000165 cofactor binding site; other site 423368000166 DNA binding site [nucleotide binding] 423368000167 substrate interaction site [chemical binding]; other site 423368000168 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 423368000169 Ligand Binding Site [chemical binding]; other site 423368000170 HD domain; Region: HD_3; cl17350 423368000171 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 423368000172 Toprim domain; Region: Toprim_3; pfam13362 423368000173 active site 423368000174 metal binding site [ion binding]; metal-binding site 423368000175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 423368000176 Transposase; Region: DEDD_Tnp_IS110; pfam01548 423368000177 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 423368000178 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 423368000179 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 423368000180 integrase/recombinase; Provisional; Region: PRK15417 423368000181 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 423368000182 Int/Topo IB signature motif; other site 423368000183 aminoglycoside resistance protein; Provisional; Region: PRK13746 423368000184 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 423368000185 active site 423368000186 NTP binding site [chemical binding]; other site 423368000187 metal binding triad [ion binding]; metal-binding site 423368000188 antibiotic binding site [chemical binding]; other site 423368000189 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 423368000190 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 423368000191 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 423368000192 oligomerisation interface [polypeptide binding]; other site 423368000193 mobile loop; other site 423368000194 roof hairpin; other site 423368000195 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 423368000196 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 423368000197 ring oligomerisation interface [polypeptide binding]; other site 423368000198 ATP/Mg binding site [chemical binding]; other site 423368000199 stacking interactions; other site 423368000200 hinge regions; other site 423368000201 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 423368000202 Putative transposase; Region: Y2_Tnp; pfam04986 423368000203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 423368000204 MULE transposase domain; Region: MULE; pfam10551 423368000205 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 423368000206 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 423368000207 dihydropteroate synthase; Region: DHPS; TIGR01496 423368000208 substrate binding pocket [chemical binding]; other site 423368000209 dimer interface [polypeptide binding]; other site 423368000210 inhibitor binding site; inhibition site 423368000211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 423368000212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368000213 Coenzyme A binding pocket [chemical binding]; other site 423368000214 transposase/IS protein; Provisional; Region: PRK09183 423368000215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368000216 Walker A motif; other site 423368000217 ATP binding site [chemical binding]; other site 423368000218 Walker B motif; other site 423368000219 arginine finger; other site 423368000220 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 423368000221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 423368000222 Integrase core domain; Region: rve; pfam00665 423368000223 Transposase; Region: HTH_Tnp_1; pfam01527 423368000224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 423368000225 putative transposase OrfB; Reviewed; Region: PHA02517 423368000226 HTH-like domain; Region: HTH_21; pfam13276 423368000227 Integrase core domain; Region: rve; pfam00665 423368000228 Integrase core domain; Region: rve_2; pfam13333 423368000229 Bacterial TniB protein; Region: TniB; pfam05621 423368000230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 423368000231 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 423368000232 Integrase core domain; Region: rve; pfam00665 423368000233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 423368000234 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 423368000235 Integrase core domain; Region: rve; pfam00665 423368000236 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368000237 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 423368000238 putative mercury resistance protein; Provisional; Region: PRK13747 423368000239 transcriptional regulator MerD; Provisional; Region: PRK13749 423368000240 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 423368000241 DNA binding residues [nucleotide binding] 423368000242 putative dimer interface [polypeptide binding]; other site 423368000243 alkylmercury lyase; Provisional; Region: PRK13239 423368000244 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 423368000245 Alkylmercury lyase; Region: MerB; pfam03243 423368000246 putative mercuric reductase; Provisional; Region: PRK13748 423368000247 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368000248 metal-binding site [ion binding] 423368000249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368000250 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 423368000251 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368000252 metal-binding site [ion binding] 423368000253 putative mercuric transport protein; Provisional; Region: PRK13751 423368000254 putative transcriptional regulator MerR; Provisional; Region: PRK13752 423368000255 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 423368000256 DNA binding residues [nucleotide binding] 423368000257 dimer interface [polypeptide binding]; other site 423368000258 mercury binding site [ion binding]; other site 423368000259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 423368000260 Transposase; Region: DEDD_Tnp_IS110; pfam01548 423368000261 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 423368000262 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 423368000263 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 423368000264 RHS Repeat; Region: RHS_repeat; pfam05593 423368000265 RHS Repeat; Region: RHS_repeat; pfam05593 423368000266 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 423368000267 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 423368000268 RHS protein; Region: RHS; pfam03527 423368000269 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 423368000270 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 423368000271 active site 423368000272 catalytic residues [active] 423368000273 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 423368000274 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368000275 active site 423368000276 DNA binding site [nucleotide binding] 423368000277 Int/Topo IB signature motif; other site 423368000278 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 423368000279 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 423368000280 active site 423368000281 catalytic site [active] 423368000282 substrate binding site [chemical binding]; other site 423368000283 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 423368000284 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 423368000285 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 423368000286 Part of AAA domain; Region: AAA_19; pfam13245 423368000287 Family description; Region: UvrD_C_2; pfam13538 423368000288 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 423368000289 F plasmid transfer operon protein; Region: TraF; pfam13728 423368000290 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 423368000291 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 423368000292 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 423368000293 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368000294 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368000295 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 423368000296 PRTRC system protein D; Region: PRTRC_D; TIGR03739 423368000297 Mg binding site [ion binding]; other site 423368000298 nucleotide binding site [chemical binding]; other site 423368000299 putative protofilament interface [polypeptide binding]; other site 423368000300 Nuclease-related domain; Region: NERD; pfam08378 423368000301 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 423368000302 Threonine operon leader 423368000303 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 423368000304 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 423368000305 putative catalytic residues [active] 423368000306 putative nucleotide binding site [chemical binding]; other site 423368000307 putative aspartate binding site [chemical binding]; other site 423368000308 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 423368000309 dimer interface [polypeptide binding]; other site 423368000310 putative threonine allosteric regulatory site; other site 423368000311 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 423368000312 putative threonine allosteric regulatory site; other site 423368000313 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 423368000314 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 423368000315 homoserine kinase; Provisional; Region: PRK01212 423368000316 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 423368000317 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 423368000318 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 423368000319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368000320 catalytic residue [active] 423368000321 hypothetical protein; Validated; Region: PRK02101 423368000322 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 423368000323 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 423368000324 transaldolase-like protein; Provisional; Region: PTZ00411 423368000325 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 423368000326 active site 423368000327 dimer interface [polypeptide binding]; other site 423368000328 catalytic residue [active] 423368000329 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 423368000330 MPT binding site; other site 423368000331 trimer interface [polypeptide binding]; other site 423368000332 hypothetical protein; Provisional; Region: PRK10659 423368000333 hypothetical protein; Provisional; Region: PRK10236 423368000334 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 423368000335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 423368000336 hypothetical protein; Provisional; Region: PRK10154 423368000337 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 423368000338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 423368000339 nucleotide binding site [chemical binding]; other site 423368000340 chaperone protein DnaJ; Provisional; Region: PRK10767 423368000341 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 423368000342 HSP70 interaction site [polypeptide binding]; other site 423368000343 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 423368000344 substrate binding site [polypeptide binding]; other site 423368000345 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 423368000346 Zn binding sites [ion binding]; other site 423368000347 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 423368000348 dimer interface [polypeptide binding]; other site 423368000349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368000350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368000351 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 423368000352 substrate binding pocket [chemical binding]; other site 423368000353 dimerization interface [polypeptide binding]; other site 423368000354 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 423368000355 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 423368000356 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 423368000357 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 423368000358 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 423368000359 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 423368000360 active site 423368000361 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 423368000362 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 423368000363 aromatic chitin/cellulose binding site residues [chemical binding]; other site 423368000364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 423368000365 Helix-turn-helix domain; Region: HTH_36; pfam13730 423368000366 fimbrial protein BcfA; Provisional; Region: PRK15187 423368000367 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 423368000368 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368000369 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368000370 outer membrane usher protein; Provisional; Region: PRK15193 423368000371 PapC N-terminal domain; Region: PapC_N; pfam13954 423368000372 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368000373 PapC C-terminal domain; Region: PapC_C; pfam13953 423368000374 fimbrial protein BcfD; Provisional; Region: PRK15189 423368000375 fimbrial protein BcfE; Provisional; Region: PRK15190 423368000376 fimbrial protein BcfF; Provisional; Region: PRK15191 423368000377 fimbrial chaperone BcfG; Provisional; Region: PRK15192 423368000378 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368000379 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368000380 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 423368000381 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 423368000382 catalytic residues [active] 423368000383 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 423368000384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368000385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368000386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368000387 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 423368000388 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 423368000389 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 423368000390 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 423368000391 active site 423368000392 metal binding site [ion binding]; metal-binding site 423368000393 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 423368000394 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 423368000395 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 423368000396 Sulfatase; Region: Sulfatase; pfam00884 423368000397 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 423368000398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368000399 FeS/SAM binding site; other site 423368000400 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 423368000401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 423368000402 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 423368000403 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 423368000404 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 423368000405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368000406 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 423368000407 putative dimerization interface [polypeptide binding]; other site 423368000408 putative alpha-glucosidase; Provisional; Region: PRK10658 423368000409 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 423368000410 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 423368000411 putative active site [active] 423368000412 putative catalytic site [active] 423368000413 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 423368000414 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 423368000415 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 423368000416 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 423368000417 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 423368000418 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 423368000419 active site 423368000420 Riboflavin kinase; Region: Flavokinase; smart00904 423368000421 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 423368000422 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 423368000423 active site 423368000424 HIGH motif; other site 423368000425 nucleotide binding site [chemical binding]; other site 423368000426 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 423368000427 active site 423368000428 KMSKS motif; other site 423368000429 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 423368000430 tRNA binding surface [nucleotide binding]; other site 423368000431 anticodon binding site; other site 423368000432 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 423368000433 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 423368000434 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 423368000435 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 423368000436 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 423368000437 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 423368000438 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 423368000439 active site 423368000440 tetramer interface [polypeptide binding]; other site 423368000441 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 423368000442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368000443 active site 423368000444 phosphorylation site [posttranslational modification] 423368000445 intermolecular recognition site; other site 423368000446 dimerization interface [polypeptide binding]; other site 423368000447 Transcriptional regulator; Region: CitT; pfam12431 423368000448 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 423368000449 PAS domain; Region: PAS; smart00091 423368000450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368000451 ATP binding site [chemical binding]; other site 423368000452 Mg2+ binding site [ion binding]; other site 423368000453 G-X-G motif; other site 423368000454 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 423368000455 oxaloacetate decarboxylase; Provisional; Region: PRK14040 423368000456 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 423368000457 active site 423368000458 catalytic residues [active] 423368000459 metal binding site [ion binding]; metal-binding site 423368000460 homodimer binding site [polypeptide binding]; other site 423368000461 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 423368000462 carboxyltransferase (CT) interaction site; other site 423368000463 biotinylation site [posttranslational modification]; other site 423368000464 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 423368000465 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 423368000466 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 423368000467 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 423368000468 putative active site [active] 423368000469 (T/H)XGH motif; other site 423368000470 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 423368000471 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 423368000472 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 423368000473 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 423368000474 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 423368000475 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 423368000476 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 423368000477 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 423368000478 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 423368000479 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 423368000480 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 423368000481 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 423368000482 catalytic site [active] 423368000483 subunit interface [polypeptide binding]; other site 423368000484 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 423368000485 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 423368000486 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 423368000487 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 423368000488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 423368000489 ATP-grasp domain; Region: ATP-grasp_4; cl17255 423368000490 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 423368000491 IMP binding site; other site 423368000492 dimer interface [polypeptide binding]; other site 423368000493 interdomain contacts; other site 423368000494 partial ornithine binding site; other site 423368000495 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 423368000496 carnitine operon protein CaiE; Provisional; Region: PRK13627 423368000497 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 423368000498 putative trimer interface [polypeptide binding]; other site 423368000499 putative metal binding site [ion binding]; other site 423368000500 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 423368000501 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 423368000502 substrate binding site [chemical binding]; other site 423368000503 oxyanion hole (OAH) forming residues; other site 423368000504 trimer interface [polypeptide binding]; other site 423368000505 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 423368000506 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 423368000507 acyl-activating enzyme (AAE) consensus motif; other site 423368000508 putative AMP binding site [chemical binding]; other site 423368000509 putative active site [active] 423368000510 putative CoA binding site [chemical binding]; other site 423368000511 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 423368000512 CoA-transferase family III; Region: CoA_transf_3; pfam02515 423368000513 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 423368000514 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 423368000515 active site 423368000516 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 423368000517 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 423368000518 Ligand binding site [chemical binding]; other site 423368000519 Electron transfer flavoprotein domain; Region: ETF; pfam01012 423368000520 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 423368000521 Electron transfer flavoprotein domain; Region: ETF; smart00893 423368000522 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 423368000523 putative oxidoreductase FixC; Provisional; Region: PRK10157 423368000524 ferredoxin-like protein FixX; Provisional; Region: PRK15449 423368000525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368000526 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 423368000527 putative substrate translocation pore; other site 423368000528 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 423368000529 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368000530 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 423368000531 Sulfatase; Region: Sulfatase; cl17466 423368000532 Sulfatase; Region: Sulfatase; cl17466 423368000533 Sulfatase; Region: Sulfatase; cl17466 423368000534 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 423368000535 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 423368000536 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 423368000537 TrkA-N domain; Region: TrkA_N; pfam02254 423368000538 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 423368000539 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 423368000540 folate binding site [chemical binding]; other site 423368000541 NADP+ binding site [chemical binding]; other site 423368000542 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 423368000543 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 423368000544 active site 423368000545 metal binding site [ion binding]; metal-binding site 423368000546 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 423368000547 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 423368000548 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 423368000549 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 423368000550 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 423368000551 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 423368000552 SurA N-terminal domain; Region: SurA_N; pfam09312 423368000553 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 423368000554 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 423368000555 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 423368000556 OstA-like protein; Region: OstA; pfam03968 423368000557 Organic solvent tolerance protein; Region: OstA_C; pfam04453 423368000558 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 423368000559 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 423368000560 putative metal binding site [ion binding]; other site 423368000561 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 423368000562 HSP70 interaction site [polypeptide binding]; other site 423368000563 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 423368000564 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 423368000565 active site 423368000566 ATP-dependent helicase HepA; Validated; Region: PRK04914 423368000567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368000568 ATP binding site [chemical binding]; other site 423368000569 putative Mg++ binding site [ion binding]; other site 423368000570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368000571 nucleotide binding region [chemical binding]; other site 423368000572 ATP-binding site [chemical binding]; other site 423368000573 DNA polymerase II; Reviewed; Region: PRK05762 423368000574 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 423368000575 active site 423368000576 catalytic site [active] 423368000577 substrate binding site [chemical binding]; other site 423368000578 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 423368000579 active site 423368000580 metal-binding site 423368000581 Uncharacterized conserved protein [Function unknown]; Region: COG1434 423368000582 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 423368000583 putative active site [active] 423368000584 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 423368000585 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 423368000586 intersubunit interface [polypeptide binding]; other site 423368000587 active site 423368000588 Zn2+ binding site [ion binding]; other site 423368000589 L-arabinose isomerase; Provisional; Region: PRK02929 423368000590 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 423368000591 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 423368000592 trimer interface [polypeptide binding]; other site 423368000593 putative substrate binding site [chemical binding]; other site 423368000594 putative metal binding site [ion binding]; other site 423368000595 ribulokinase; Provisional; Region: PRK04123 423368000596 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 423368000597 N- and C-terminal domain interface [polypeptide binding]; other site 423368000598 active site 423368000599 MgATP binding site [chemical binding]; other site 423368000600 catalytic site [active] 423368000601 metal binding site [ion binding]; metal-binding site 423368000602 carbohydrate binding site [chemical binding]; other site 423368000603 homodimer interface [polypeptide binding]; other site 423368000604 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 423368000605 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 423368000606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368000607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368000608 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 423368000609 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 423368000610 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 423368000611 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 423368000612 Walker A/P-loop; other site 423368000613 ATP binding site [chemical binding]; other site 423368000614 Q-loop/lid; other site 423368000615 ABC transporter signature motif; other site 423368000616 Walker B; other site 423368000617 D-loop; other site 423368000618 H-loop/switch region; other site 423368000619 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 423368000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368000621 dimer interface [polypeptide binding]; other site 423368000622 conserved gate region; other site 423368000623 putative PBP binding loops; other site 423368000624 ABC-ATPase subunit interface; other site 423368000625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368000626 dimer interface [polypeptide binding]; other site 423368000627 conserved gate region; other site 423368000628 putative PBP binding loops; other site 423368000629 ABC-ATPase subunit interface; other site 423368000630 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 423368000631 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 423368000632 transcriptional regulator SgrR; Provisional; Region: PRK13626 423368000633 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 423368000634 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 423368000635 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 423368000636 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 423368000637 substrate binding site [chemical binding]; other site 423368000638 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 423368000639 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 423368000640 substrate binding site [chemical binding]; other site 423368000641 ligand binding site [chemical binding]; other site 423368000642 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 423368000643 tartrate dehydrogenase; Region: TTC; TIGR02089 423368000644 2-isopropylmalate synthase; Validated; Region: PRK00915 423368000645 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 423368000646 active site 423368000647 catalytic residues [active] 423368000648 metal binding site [ion binding]; metal-binding site 423368000649 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 423368000650 Leucine operon leader 423368000651 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 423368000652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368000653 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 423368000654 putative substrate binding pocket [chemical binding]; other site 423368000655 putative dimerization interface [polypeptide binding]; other site 423368000656 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 423368000657 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 423368000658 PYR/PP interface [polypeptide binding]; other site 423368000659 dimer interface [polypeptide binding]; other site 423368000660 TPP binding site [chemical binding]; other site 423368000661 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 423368000662 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 423368000663 TPP-binding site [chemical binding]; other site 423368000664 dimer interface [polypeptide binding]; other site 423368000665 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 423368000666 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 423368000667 putative valine binding site [chemical binding]; other site 423368000668 dimer interface [polypeptide binding]; other site 423368000669 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 423368000670 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 423368000671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368000672 DNA binding site [nucleotide binding] 423368000673 domain linker motif; other site 423368000674 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 423368000675 dimerization interface [polypeptide binding]; other site 423368000676 ligand binding site [chemical binding]; other site 423368000677 mraZ protein; Region: TIGR00242 423368000678 MraZ protein; Region: MraZ; pfam02381 423368000679 MraZ protein; Region: MraZ; pfam02381 423368000680 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 423368000681 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 423368000682 cell division protein FtsL; Provisional; Region: PRK10772 423368000683 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 423368000684 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 423368000685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 423368000686 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 423368000687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 423368000688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 423368000689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 423368000690 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 423368000691 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 423368000692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 423368000693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 423368000694 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 423368000695 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 423368000696 Mg++ binding site [ion binding]; other site 423368000697 putative catalytic motif [active] 423368000698 putative substrate binding site [chemical binding]; other site 423368000699 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 423368000700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 423368000701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 423368000702 cell division protein FtsW; Provisional; Region: PRK10774 423368000703 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 423368000704 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 423368000705 active site 423368000706 homodimer interface [polypeptide binding]; other site 423368000707 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 423368000708 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 423368000709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 423368000710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 423368000711 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 423368000712 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 423368000713 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 423368000714 cell division protein FtsQ; Provisional; Region: PRK10775 423368000715 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 423368000716 Cell division protein FtsQ; Region: FtsQ; pfam03799 423368000717 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 423368000718 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368000719 Cell division protein FtsA; Region: FtsA; pfam14450 423368000720 cell division protein FtsZ; Validated; Region: PRK09330 423368000721 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 423368000722 nucleotide binding site [chemical binding]; other site 423368000723 SulA interaction site; other site 423368000724 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 423368000725 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 423368000726 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 423368000727 SecA regulator SecM; Provisional; Region: PRK02943 423368000728 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 423368000729 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 423368000730 SEC-C motif; Region: SEC-C; pfam02810 423368000731 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 423368000732 active site 423368000733 8-oxo-dGMP binding site [chemical binding]; other site 423368000734 nudix motif; other site 423368000735 metal binding site [ion binding]; metal-binding site 423368000736 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 423368000737 DNA gyrase inhibitor; Reviewed; Region: PRK00418 423368000738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 423368000739 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 423368000740 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 423368000741 CoA-binding site [chemical binding]; other site 423368000742 ATP-binding [chemical binding]; other site 423368000743 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 423368000744 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 423368000745 active site 423368000746 type IV pilin biogenesis protein; Provisional; Region: PRK10573 423368000747 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 423368000748 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 423368000749 hypothetical protein; Provisional; Region: PRK10436 423368000750 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 423368000751 Walker A motif; other site 423368000752 ATP binding site [chemical binding]; other site 423368000753 Walker B motif; other site 423368000754 putative major pilin subunit; Provisional; Region: PRK10574 423368000755 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 423368000756 Pilin (bacterial filament); Region: Pilin; pfam00114 423368000757 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 423368000758 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 423368000759 dimerization interface [polypeptide binding]; other site 423368000760 active site 423368000761 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 423368000762 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 423368000763 amidase catalytic site [active] 423368000764 Zn binding residues [ion binding]; other site 423368000765 substrate binding site [chemical binding]; other site 423368000766 regulatory protein AmpE; Provisional; Region: PRK10987 423368000767 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 423368000768 active site 423368000769 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 423368000770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368000771 putative substrate translocation pore; other site 423368000772 aromatic amino acid transporter; Provisional; Region: PRK10238 423368000773 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 423368000774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368000775 DNA-binding site [nucleotide binding]; DNA binding site 423368000776 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 423368000777 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 423368000778 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 423368000779 dimer interface [polypeptide binding]; other site 423368000780 TPP-binding site [chemical binding]; other site 423368000781 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 423368000782 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 423368000783 E3 interaction surface; other site 423368000784 lipoyl attachment site [posttranslational modification]; other site 423368000785 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 423368000786 E3 interaction surface; other site 423368000787 lipoyl attachment site [posttranslational modification]; other site 423368000788 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 423368000789 E3 interaction surface; other site 423368000790 lipoyl attachment site [posttranslational modification]; other site 423368000791 e3 binding domain; Region: E3_binding; pfam02817 423368000792 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 423368000793 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 423368000794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 423368000795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368000796 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 423368000797 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 423368000798 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 423368000799 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 423368000800 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 423368000801 substrate binding site [chemical binding]; other site 423368000802 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 423368000803 substrate binding site [chemical binding]; other site 423368000804 ligand binding site [chemical binding]; other site 423368000805 putative inner membrane protein; Provisional; Region: PRK09823 423368000806 Low molecular weight phosphatase family; Region: LMWPc; cl00105 423368000807 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 423368000808 active site 423368000809 hypothetical protein; Provisional; Region: PRK05248 423368000810 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 423368000811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 423368000812 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 423368000813 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 423368000814 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368000815 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368000816 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368000817 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 423368000818 spermidine synthase; Provisional; Region: PRK00811 423368000819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368000820 S-adenosylmethionine binding site [chemical binding]; other site 423368000821 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 423368000822 multicopper oxidase; Provisional; Region: PRK10965 423368000823 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 423368000824 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 423368000825 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 423368000826 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 423368000827 Trp docking motif [polypeptide binding]; other site 423368000828 putative active site [active] 423368000829 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 423368000830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368000831 active site 423368000832 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 423368000833 active site clefts [active] 423368000834 zinc binding site [ion binding]; other site 423368000835 dimer interface [polypeptide binding]; other site 423368000836 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 423368000837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 423368000838 Walker A/P-loop; other site 423368000839 ATP binding site [chemical binding]; other site 423368000840 Q-loop/lid; other site 423368000841 ABC transporter signature motif; other site 423368000842 Walker B; other site 423368000843 D-loop; other site 423368000844 H-loop/switch region; other site 423368000845 inner membrane transport permease; Provisional; Region: PRK15066 423368000846 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 423368000847 putative fimbrial protein StiH; Provisional; Region: PRK15297 423368000848 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 423368000849 PapC N-terminal domain; Region: PapC_N; pfam13954 423368000850 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368000851 PapC C-terminal domain; Region: PapC_C; pfam13953 423368000852 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 423368000853 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368000854 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368000855 fimbrial protein StiA; Provisional; Region: PRK15300 423368000856 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368000857 active pocket/dimerization site; other site 423368000858 active site 423368000859 phosphorylation site [posttranslational modification] 423368000860 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 423368000861 putative active site [active] 423368000862 putative metal binding site [ion binding]; other site 423368000863 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 423368000864 tetramerization interface [polypeptide binding]; other site 423368000865 active site 423368000866 Pantoate-beta-alanine ligase; Region: PanC; cd00560 423368000867 pantoate--beta-alanine ligase; Region: panC; TIGR00018 423368000868 active site 423368000869 ATP-binding site [chemical binding]; other site 423368000870 pantoate-binding site; other site 423368000871 HXXH motif; other site 423368000872 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 423368000873 oligomerization interface [polypeptide binding]; other site 423368000874 active site 423368000875 metal binding site [ion binding]; metal-binding site 423368000876 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 423368000877 catalytic center binding site [active] 423368000878 ATP binding site [chemical binding]; other site 423368000879 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 423368000880 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 423368000881 active site 423368000882 NTP binding site [chemical binding]; other site 423368000883 metal binding triad [ion binding]; metal-binding site 423368000884 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 423368000885 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 423368000886 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 423368000887 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 423368000888 active site 423368000889 nucleotide binding site [chemical binding]; other site 423368000890 HIGH motif; other site 423368000891 KMSKS motif; other site 423368000892 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 423368000893 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 423368000894 2'-5' RNA ligase; Provisional; Region: PRK15124 423368000895 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 423368000896 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 423368000897 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 423368000898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368000899 ATP binding site [chemical binding]; other site 423368000900 putative Mg++ binding site [ion binding]; other site 423368000901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368000902 nucleotide binding region [chemical binding]; other site 423368000903 ATP-binding site [chemical binding]; other site 423368000904 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 423368000905 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 423368000906 Transglycosylase; Region: Transgly; pfam00912 423368000907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 423368000908 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 423368000909 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368000910 N-terminal plug; other site 423368000911 ligand-binding site [chemical binding]; other site 423368000912 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 423368000913 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 423368000914 Walker A/P-loop; other site 423368000915 ATP binding site [chemical binding]; other site 423368000916 Q-loop/lid; other site 423368000917 ABC transporter signature motif; other site 423368000918 Walker B; other site 423368000919 D-loop; other site 423368000920 H-loop/switch region; other site 423368000921 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 423368000922 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 423368000923 siderophore binding site; other site 423368000924 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 423368000925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368000926 ABC-ATPase subunit interface; other site 423368000927 dimer interface [polypeptide binding]; other site 423368000928 putative PBP binding regions; other site 423368000929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368000930 ABC-ATPase subunit interface; other site 423368000931 dimer interface [polypeptide binding]; other site 423368000932 putative PBP binding regions; other site 423368000933 putative fimbrial subunit StfA; Provisional; Region: PRK15283 423368000934 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 423368000935 PapC N-terminal domain; Region: PapC_N; pfam13954 423368000936 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368000937 PapC C-terminal domain; Region: PapC_C; pfam13953 423368000938 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 423368000939 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368000940 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368000941 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 423368000942 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 423368000943 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 423368000944 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 423368000945 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 423368000946 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 423368000947 inhibitor-cofactor binding pocket; inhibition site 423368000948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368000949 catalytic residue [active] 423368000950 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 423368000951 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 423368000952 Cl- selectivity filter; other site 423368000953 Cl- binding residues [ion binding]; other site 423368000954 pore gating glutamate residue; other site 423368000955 dimer interface [polypeptide binding]; other site 423368000956 H+/Cl- coupling transport residue; other site 423368000957 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 423368000958 hypothetical protein; Provisional; Region: PRK10578 423368000959 UPF0126 domain; Region: UPF0126; pfam03458 423368000960 UPF0126 domain; Region: UPF0126; pfam03458 423368000961 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 423368000962 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 423368000963 cobalamin binding residues [chemical binding]; other site 423368000964 putative BtuC binding residues; other site 423368000965 dimer interface [polypeptide binding]; other site 423368000966 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 423368000967 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 423368000968 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 423368000969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 423368000970 Zn2+ binding site [ion binding]; other site 423368000971 Mg2+ binding site [ion binding]; other site 423368000972 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 423368000973 serine endoprotease; Provisional; Region: PRK10942 423368000974 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 423368000975 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 423368000976 protein binding site [polypeptide binding]; other site 423368000977 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 423368000978 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 423368000979 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 423368000980 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 423368000981 hypothetical protein; Provisional; Region: PRK13677 423368000982 shikimate transporter; Provisional; Region: PRK09952 423368000983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368000984 putative substrate translocation pore; other site 423368000985 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 423368000986 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 423368000987 trimer interface [polypeptide binding]; other site 423368000988 active site 423368000989 substrate binding site [chemical binding]; other site 423368000990 CoA binding site [chemical binding]; other site 423368000991 PII uridylyl-transferase; Provisional; Region: PRK05007 423368000992 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 423368000993 metal binding triad; other site 423368000994 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 423368000995 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 423368000996 Zn2+ binding site [ion binding]; other site 423368000997 Mg2+ binding site [ion binding]; other site 423368000998 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 423368000999 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 423368001000 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 423368001001 active site 423368001002 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 423368001003 rRNA interaction site [nucleotide binding]; other site 423368001004 S8 interaction site; other site 423368001005 putative laminin-1 binding site; other site 423368001006 elongation factor Ts; Provisional; Region: tsf; PRK09377 423368001007 UBA/TS-N domain; Region: UBA; pfam00627 423368001008 Elongation factor TS; Region: EF_TS; pfam00889 423368001009 Elongation factor TS; Region: EF_TS; pfam00889 423368001010 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 423368001011 putative nucleotide binding site [chemical binding]; other site 423368001012 uridine monophosphate binding site [chemical binding]; other site 423368001013 homohexameric interface [polypeptide binding]; other site 423368001014 ribosome recycling factor; Reviewed; Region: frr; PRK00083 423368001015 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 423368001016 hinge region; other site 423368001017 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 423368001018 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 423368001019 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 423368001020 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 423368001021 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 423368001022 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 423368001023 catalytic residue [active] 423368001024 putative FPP diphosphate binding site; other site 423368001025 putative FPP binding hydrophobic cleft; other site 423368001026 dimer interface [polypeptide binding]; other site 423368001027 putative IPP diphosphate binding site; other site 423368001028 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 423368001029 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 423368001030 zinc metallopeptidase RseP; Provisional; Region: PRK10779 423368001031 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 423368001032 active site 423368001033 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 423368001034 protein binding site [polypeptide binding]; other site 423368001035 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 423368001036 protein binding site [polypeptide binding]; other site 423368001037 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 423368001038 putative substrate binding region [chemical binding]; other site 423368001039 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 423368001040 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 423368001041 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 423368001042 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 423368001043 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 423368001044 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 423368001045 Surface antigen; Region: Bac_surface_Ag; pfam01103 423368001046 periplasmic chaperone; Provisional; Region: PRK10780 423368001047 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 423368001048 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 423368001049 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 423368001050 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 423368001051 trimer interface [polypeptide binding]; other site 423368001052 active site 423368001053 UDP-GlcNAc binding site [chemical binding]; other site 423368001054 lipid binding site [chemical binding]; lipid-binding site 423368001055 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 423368001056 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 423368001057 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 423368001058 active site 423368001059 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 423368001060 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 423368001061 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 423368001062 RNA/DNA hybrid binding site [nucleotide binding]; other site 423368001063 active site 423368001064 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 423368001065 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 423368001066 putative active site [active] 423368001067 putative PHP Thumb interface [polypeptide binding]; other site 423368001068 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 423368001069 generic binding surface II; other site 423368001070 generic binding surface I; other site 423368001071 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 423368001072 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 423368001073 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 423368001074 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 423368001075 putative sugar binding site [chemical binding]; other site 423368001076 catalytic residues [active] 423368001077 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 423368001078 lysine decarboxylase LdcC; Provisional; Region: PRK15399 423368001079 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 423368001080 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 423368001081 homodimer interface [polypeptide binding]; other site 423368001082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368001083 catalytic residue [active] 423368001084 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 423368001085 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 423368001086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 423368001087 putative metal binding site [ion binding]; other site 423368001088 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 423368001089 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 423368001090 Ligand Binding Site [chemical binding]; other site 423368001091 TilS substrate binding domain; Region: TilS; pfam09179 423368001092 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 423368001093 Rho-binding antiterminator; Provisional; Region: PRK11625 423368001094 hypothetical protein; Provisional; Region: PRK04964 423368001095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 423368001096 hypothetical protein; Provisional; Region: PRK09256 423368001097 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 423368001098 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 423368001099 NlpE N-terminal domain; Region: NlpE; pfam04170 423368001100 prolyl-tRNA synthetase; Provisional; Region: PRK09194 423368001101 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 423368001102 dimer interface [polypeptide binding]; other site 423368001103 motif 1; other site 423368001104 active site 423368001105 motif 2; other site 423368001106 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 423368001107 putative deacylase active site [active] 423368001108 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 423368001109 active site 423368001110 motif 3; other site 423368001111 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 423368001112 anticodon binding site; other site 423368001113 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 423368001114 homodimer interaction site [polypeptide binding]; other site 423368001115 cofactor binding site; other site 423368001116 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 423368001117 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 423368001118 lipoprotein, YaeC family; Region: TIGR00363 423368001119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368001120 dimer interface [polypeptide binding]; other site 423368001121 conserved gate region; other site 423368001122 ABC-ATPase subunit interface; other site 423368001123 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 423368001124 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 423368001125 Walker A/P-loop; other site 423368001126 ATP binding site [chemical binding]; other site 423368001127 Q-loop/lid; other site 423368001128 ABC transporter signature motif; other site 423368001129 Walker B; other site 423368001130 D-loop; other site 423368001131 H-loop/switch region; other site 423368001132 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 423368001133 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 423368001134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368001135 active site 423368001136 motif I; other site 423368001137 motif II; other site 423368001138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368001139 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368001140 active site 423368001141 catalytic tetrad [active] 423368001142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368001143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368001144 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 423368001145 putative effector binding pocket; other site 423368001146 dimerization interface [polypeptide binding]; other site 423368001147 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 423368001148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001149 putative substrate translocation pore; other site 423368001150 hypothetical protein; Provisional; Region: PRK05421 423368001151 putative catalytic site [active] 423368001152 putative metal binding site [ion binding]; other site 423368001153 putative phosphate binding site [ion binding]; other site 423368001154 putative catalytic site [active] 423368001155 putative phosphate binding site [ion binding]; other site 423368001156 putative metal binding site [ion binding]; other site 423368001157 Methyltransferase domain; Region: Methyltransf_23; pfam13489 423368001158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368001159 S-adenosylmethionine binding site [chemical binding]; other site 423368001160 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 423368001161 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368001162 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368001163 catalytic residue [active] 423368001164 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368001165 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368001166 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 423368001167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368001168 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 423368001169 RNA/DNA hybrid binding site [nucleotide binding]; other site 423368001170 active site 423368001171 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 423368001172 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 423368001173 active site 423368001174 catalytic site [active] 423368001175 substrate binding site [chemical binding]; other site 423368001176 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 423368001177 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 423368001178 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 423368001179 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 423368001180 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 423368001181 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 423368001182 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 423368001183 ImpE protein; Region: ImpE; pfam07024 423368001184 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 423368001185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368001186 Walker A motif; other site 423368001187 ATP binding site [chemical binding]; other site 423368001188 Walker B motif; other site 423368001189 arginine finger; other site 423368001190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368001191 Walker A motif; other site 423368001192 ATP binding site [chemical binding]; other site 423368001193 Walker B motif; other site 423368001194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 423368001195 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 423368001196 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 423368001197 Protein of unknown function (DUF877); Region: DUF877; pfam05943 423368001198 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 423368001199 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 423368001200 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 423368001201 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 423368001202 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 423368001203 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 423368001204 hypothetical protein; Provisional; Region: PRK08126 423368001205 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 423368001206 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 423368001207 ligand binding site [chemical binding]; other site 423368001208 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 423368001209 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 423368001210 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 423368001211 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 423368001212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 423368001213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 423368001214 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 423368001215 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 423368001216 Uncharacterized conserved protein [Function unknown]; Region: COG5435 423368001217 PAAR motif; Region: PAAR_motif; pfam05488 423368001218 RHS Repeat; Region: RHS_repeat; pfam05593 423368001219 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 423368001220 RHS Repeat; Region: RHS_repeat; pfam05593 423368001221 RHS Repeat; Region: RHS_repeat; pfam05593 423368001222 RHS protein; Region: RHS; pfam03527 423368001223 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 423368001224 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 423368001225 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 423368001226 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 423368001227 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 423368001228 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368001229 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368001230 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 423368001231 PapC N-terminal domain; Region: PapC_N; pfam13954 423368001232 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368001233 PapC C-terminal domain; Region: PapC_C; pfam13953 423368001234 putative pilin structural protein SafD; Provisional; Region: PRK15222 423368001235 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 423368001236 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 423368001237 putative active site [active] 423368001238 putative metal binding site [ion binding]; other site 423368001239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368001240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368001241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368001242 dimerization interface [polypeptide binding]; other site 423368001243 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 423368001244 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 423368001245 dimer interface [polypeptide binding]; other site 423368001246 C-N hydrolase family amidase; Provisional; Region: PRK10438 423368001247 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 423368001248 putative active site [active] 423368001249 catalytic triad [active] 423368001250 dimer interface [polypeptide binding]; other site 423368001251 multimer interface [polypeptide binding]; other site 423368001252 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 423368001253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 423368001254 active site 423368001255 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 423368001256 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 423368001257 dimer interface [polypeptide binding]; other site 423368001258 active site 423368001259 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 423368001260 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 423368001261 putative active site [active] 423368001262 putative dimer interface [polypeptide binding]; other site 423368001263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 423368001264 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368001265 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 423368001266 active site 423368001267 DNA polymerase IV; Validated; Region: PRK02406 423368001268 DNA binding site [nucleotide binding] 423368001269 hypothetical protein; Reviewed; Region: PRK09588 423368001270 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 423368001271 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 423368001272 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 423368001273 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 423368001274 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 423368001275 metal binding site [ion binding]; metal-binding site 423368001276 dimer interface [polypeptide binding]; other site 423368001277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368001278 active site 423368001279 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 423368001280 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 423368001281 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368001282 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368001283 trimer interface [polypeptide binding]; other site 423368001284 eyelet of channel; other site 423368001285 gamma-glutamyl kinase; Provisional; Region: PRK05429 423368001286 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 423368001287 nucleotide binding site [chemical binding]; other site 423368001288 homotetrameric interface [polypeptide binding]; other site 423368001289 putative phosphate binding site [ion binding]; other site 423368001290 putative allosteric binding site; other site 423368001291 PUA domain; Region: PUA; pfam01472 423368001292 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 423368001293 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 423368001294 putative catalytic cysteine [active] 423368001295 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 423368001296 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 423368001297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001298 putative substrate translocation pore; other site 423368001299 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 423368001300 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 423368001301 substrate binding site [chemical binding]; other site 423368001302 ligand binding site [chemical binding]; other site 423368001303 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 423368001304 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 423368001305 hypothetical protein; Provisional; Region: PRK14812 423368001306 substrate binding site [chemical binding]; other site 423368001307 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 423368001308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 423368001309 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 423368001310 transcriptional activator TtdR; Provisional; Region: PRK09801 423368001311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368001312 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 423368001313 putative effector binding pocket; other site 423368001314 putative dimerization interface [polypeptide binding]; other site 423368001315 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 423368001316 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368001317 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368001318 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 423368001319 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 423368001320 PapC N-terminal domain; Region: PapC_N; pfam13954 423368001321 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368001322 PapC C-terminal domain; Region: PapC_C; pfam13953 423368001323 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 423368001324 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368001325 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368001326 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 423368001327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 423368001328 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 423368001329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368001330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 423368001331 DNA binding site [nucleotide binding] 423368001332 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 423368001333 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 423368001334 DNA binding residues [nucleotide binding] 423368001335 dimerization interface [polypeptide binding]; other site 423368001336 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 423368001337 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 423368001338 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 423368001339 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 423368001340 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368001341 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368001342 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 423368001343 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368001344 metal-binding site [ion binding] 423368001345 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 423368001346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368001347 motif II; other site 423368001348 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 423368001349 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 423368001350 DNA binding residues [nucleotide binding] 423368001351 dimer interface [polypeptide binding]; other site 423368001352 copper binding site [ion binding]; other site 423368001353 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368001354 metal-binding site [ion binding] 423368001355 putative sialic acid transporter; Region: 2A0112; TIGR00891 423368001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001357 putative substrate translocation pore; other site 423368001358 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 423368001359 DNA methylase; Region: N6_N4_Mtase; cl17433 423368001360 DNA methylase; Region: N6_N4_Mtase; pfam01555 423368001361 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 423368001362 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 423368001363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 423368001364 VRR-NUC domain; Region: VRR_NUC; pfam08774 423368001365 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 423368001366 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 423368001367 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 423368001368 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 423368001369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368001370 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 423368001371 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368001372 N-terminal plug; other site 423368001373 ligand-binding site [chemical binding]; other site 423368001374 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 423368001375 hypothetical protein; Provisional; Region: PRK09929 423368001376 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 423368001377 Propionate catabolism activator; Region: PrpR_N; pfam06506 423368001378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368001379 Walker A motif; other site 423368001380 ATP binding site [chemical binding]; other site 423368001381 Walker B motif; other site 423368001382 arginine finger; other site 423368001383 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 423368001384 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 423368001385 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 423368001386 tetramer interface [polypeptide binding]; other site 423368001387 active site 423368001388 Mg2+/Mn2+ binding site [ion binding]; other site 423368001389 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 423368001390 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 423368001391 dimer interface [polypeptide binding]; other site 423368001392 active site 423368001393 citrylCoA binding site [chemical binding]; other site 423368001394 oxalacetate/citrate binding site [chemical binding]; other site 423368001395 coenzyme A binding site [chemical binding]; other site 423368001396 catalytic triad [active] 423368001397 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 423368001398 2-methylcitrate dehydratase; Region: prpD; TIGR02330 423368001399 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 423368001400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 423368001401 acyl-activating enzyme (AAE) consensus motif; other site 423368001402 AMP binding site [chemical binding]; other site 423368001403 active site 423368001404 CoA binding site [chemical binding]; other site 423368001405 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 423368001406 dimer interface [polypeptide binding]; other site 423368001407 active site 423368001408 Schiff base residues; other site 423368001409 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 423368001410 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 423368001411 Autotransporter beta-domain; Region: Autotransporter; pfam03797 423368001412 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 423368001413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 423368001414 ligand binding site [chemical binding]; other site 423368001415 flexible hinge region; other site 423368001416 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 423368001417 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 423368001418 microcin B17 transporter; Reviewed; Region: PRK11098 423368001419 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 423368001420 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 423368001421 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 423368001422 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 423368001423 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 423368001424 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 423368001425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 423368001426 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 423368001427 drug efflux system protein MdtG; Provisional; Region: PRK09874 423368001428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001429 putative substrate translocation pore; other site 423368001430 anti-RssB factor; Provisional; Region: PRK10244 423368001431 hypothetical protein; Provisional; Region: PRK11505 423368001432 psiF repeat; Region: PsiF_repeat; pfam07769 423368001433 psiF repeat; Region: PsiF_repeat; pfam07769 423368001434 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 423368001435 MASE2 domain; Region: MASE2; pfam05230 423368001436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368001437 metal binding site [ion binding]; metal-binding site 423368001438 active site 423368001439 I-site; other site 423368001440 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 423368001441 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 423368001442 hypothetical protein; Validated; Region: PRK00124 423368001443 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 423368001444 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 423368001445 ADP binding site [chemical binding]; other site 423368001446 magnesium binding site [ion binding]; other site 423368001447 putative shikimate binding site; other site 423368001448 hypothetical protein; Provisional; Region: PRK10380 423368001449 hypothetical protein; Provisional; Region: PRK10481 423368001450 hypothetical protein; Provisional; Region: PRK10579 423368001451 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 423368001452 fructokinase; Reviewed; Region: PRK09557 423368001453 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368001454 nucleotide binding site [chemical binding]; other site 423368001455 MFS transport protein AraJ; Provisional; Region: PRK10091 423368001456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001457 putative substrate translocation pore; other site 423368001458 exonuclease subunit SbcC; Provisional; Region: PRK10246 423368001459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368001460 Walker A/P-loop; other site 423368001461 ATP binding site [chemical binding]; other site 423368001462 Q-loop/lid; other site 423368001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368001464 ABC transporter signature motif; other site 423368001465 Walker B; other site 423368001466 D-loop; other site 423368001467 H-loop/switch region; other site 423368001468 exonuclease subunit SbcD; Provisional; Region: PRK10966 423368001469 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 423368001470 active site 423368001471 metal binding site [ion binding]; metal-binding site 423368001472 DNA binding site [nucleotide binding] 423368001473 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 423368001474 transcriptional regulator PhoB; Provisional; Region: PRK10161 423368001475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368001476 active site 423368001477 phosphorylation site [posttranslational modification] 423368001478 intermolecular recognition site; other site 423368001479 dimerization interface [polypeptide binding]; other site 423368001480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368001481 DNA binding site [nucleotide binding] 423368001482 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 423368001483 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 423368001484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368001485 putative active site [active] 423368001486 heme pocket [chemical binding]; other site 423368001487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368001488 dimer interface [polypeptide binding]; other site 423368001489 phosphorylation site [posttranslational modification] 423368001490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368001491 ATP binding site [chemical binding]; other site 423368001492 Mg2+ binding site [ion binding]; other site 423368001493 G-X-G motif; other site 423368001494 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 423368001495 putative proline-specific permease; Provisional; Region: proY; PRK10580 423368001496 maltodextrin glucosidase; Provisional; Region: PRK10785 423368001497 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 423368001498 homodimer interface [polypeptide binding]; other site 423368001499 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 423368001500 active site 423368001501 homodimer interface [polypeptide binding]; other site 423368001502 catalytic site [active] 423368001503 peroxidase; Provisional; Region: PRK15000 423368001504 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 423368001505 dimer interface [polypeptide binding]; other site 423368001506 decamer (pentamer of dimers) interface [polypeptide binding]; other site 423368001507 catalytic triad [active] 423368001508 peroxidatic and resolving cysteines [active] 423368001509 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 423368001510 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 423368001511 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 423368001512 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 423368001513 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 423368001514 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 423368001515 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 423368001516 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 423368001517 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 423368001518 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 423368001519 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 423368001520 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 423368001521 Protein export membrane protein; Region: SecD_SecF; pfam02355 423368001522 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 423368001523 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 423368001524 Predicted transcriptional regulator [Transcription]; Region: COG2378 423368001525 HTH domain; Region: HTH_11; pfam08279 423368001526 WYL domain; Region: WYL; pfam13280 423368001527 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 423368001528 active site 423368001529 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 423368001530 hypothetical protein; Provisional; Region: PRK11530 423368001531 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 423368001532 ATP cone domain; Region: ATP-cone; pfam03477 423368001533 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 423368001534 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 423368001535 catalytic motif [active] 423368001536 Zn binding site [ion binding]; other site 423368001537 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 423368001538 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 423368001539 homopentamer interface [polypeptide binding]; other site 423368001540 active site 423368001541 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 423368001542 putative RNA binding site [nucleotide binding]; other site 423368001543 thiamine monophosphate kinase; Provisional; Region: PRK05731 423368001544 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 423368001545 ATP binding site [chemical binding]; other site 423368001546 dimerization interface [polypeptide binding]; other site 423368001547 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 423368001548 tetramer interfaces [polypeptide binding]; other site 423368001549 binuclear metal-binding site [ion binding]; other site 423368001550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368001551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368001552 active site 423368001553 catalytic tetrad [active] 423368001554 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 423368001555 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 423368001556 TPP-binding site; other site 423368001557 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 423368001558 PYR/PP interface [polypeptide binding]; other site 423368001559 dimer interface [polypeptide binding]; other site 423368001560 TPP binding site [chemical binding]; other site 423368001561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 423368001562 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 423368001563 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 423368001564 substrate binding pocket [chemical binding]; other site 423368001565 chain length determination region; other site 423368001566 substrate-Mg2+ binding site; other site 423368001567 catalytic residues [active] 423368001568 aspartate-rich region 1; other site 423368001569 active site lid residues [active] 423368001570 aspartate-rich region 2; other site 423368001571 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 423368001572 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 423368001573 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 423368001574 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 423368001575 Ligand Binding Site [chemical binding]; other site 423368001576 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 423368001577 active site residue [active] 423368001578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 423368001579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368001580 dimer interface [polypeptide binding]; other site 423368001581 conserved gate region; other site 423368001582 putative PBP binding loops; other site 423368001583 ABC-ATPase subunit interface; other site 423368001584 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 423368001585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368001586 dimer interface [polypeptide binding]; other site 423368001587 conserved gate region; other site 423368001588 putative PBP binding loops; other site 423368001589 ABC-ATPase subunit interface; other site 423368001590 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 423368001591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368001592 Walker A/P-loop; other site 423368001593 ATP binding site [chemical binding]; other site 423368001594 Q-loop/lid; other site 423368001595 ABC transporter signature motif; other site 423368001596 Walker B; other site 423368001597 D-loop; other site 423368001598 H-loop/switch region; other site 423368001599 TOBE domain; Region: TOBE_2; pfam08402 423368001600 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 423368001601 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 423368001602 transcriptional regulator protein; Region: phnR; TIGR03337 423368001603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368001604 DNA-binding site [nucleotide binding]; DNA binding site 423368001605 UTRA domain; Region: UTRA; pfam07702 423368001606 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 423368001607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368001608 catalytic residue [active] 423368001609 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 423368001610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368001611 motif II; other site 423368001612 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 423368001613 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 423368001614 conserved cys residue [active] 423368001615 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 423368001616 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 423368001617 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 423368001618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 423368001619 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 423368001620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368001622 putative substrate translocation pore; other site 423368001623 Sel1-like repeats; Region: SEL1; smart00671 423368001624 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368001625 Sel1 repeat; Region: Sel1; pfam08238 423368001626 Sel1-like repeats; Region: SEL1; smart00671 423368001627 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368001628 Sel1-like repeats; Region: SEL1; smart00671 423368001629 Sel1-like repeats; Region: SEL1; smart00671 423368001630 Sel1-like repeats; Region: SEL1; smart00671 423368001631 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 423368001632 UbiA prenyltransferase family; Region: UbiA; pfam01040 423368001633 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 423368001634 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 423368001635 Subunit I/III interface [polypeptide binding]; other site 423368001636 Subunit III/IV interface [polypeptide binding]; other site 423368001637 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 423368001638 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 423368001639 D-pathway; other site 423368001640 Putative ubiquinol binding site [chemical binding]; other site 423368001641 Low-spin heme (heme b) binding site [chemical binding]; other site 423368001642 Putative water exit pathway; other site 423368001643 Binuclear center (heme o3/CuB) [ion binding]; other site 423368001644 K-pathway; other site 423368001645 Putative proton exit pathway; other site 423368001646 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 423368001647 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 423368001648 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 423368001649 muropeptide transporter; Reviewed; Region: ampG; PRK11902 423368001650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001651 putative substrate translocation pore; other site 423368001652 hypothetical protein; Provisional; Region: PRK11627 423368001653 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 423368001654 transcriptional regulator BolA; Provisional; Region: PRK11628 423368001655 trigger factor; Provisional; Region: tig; PRK01490 423368001656 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 423368001657 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 423368001658 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 423368001659 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 423368001660 oligomer interface [polypeptide binding]; other site 423368001661 active site residues [active] 423368001662 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 423368001663 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 423368001664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368001665 Walker A motif; other site 423368001666 ATP binding site [chemical binding]; other site 423368001667 Walker B motif; other site 423368001668 Iron permease FTR1 family; Region: FTR1; cl00475 423368001669 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 423368001670 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 423368001671 Found in ATP-dependent protease La (LON); Region: LON; smart00464 423368001672 Found in ATP-dependent protease La (LON); Region: LON; smart00464 423368001673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368001674 Walker A motif; other site 423368001675 ATP binding site [chemical binding]; other site 423368001676 Walker B motif; other site 423368001677 arginine finger; other site 423368001678 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 423368001679 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 423368001680 IHF dimer interface [polypeptide binding]; other site 423368001681 IHF - DNA interface [nucleotide binding]; other site 423368001682 periplasmic folding chaperone; Provisional; Region: PRK10788 423368001683 SurA N-terminal domain; Region: SurA_N_3; cl07813 423368001684 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 423368001685 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 423368001686 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 423368001687 active site 423368001688 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 423368001689 Ligand Binding Site [chemical binding]; other site 423368001690 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 423368001691 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 423368001692 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 423368001693 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 423368001694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368001695 active site 423368001696 motif I; other site 423368001697 motif II; other site 423368001698 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 423368001699 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 423368001700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368001701 catalytic residue [active] 423368001702 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 423368001703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368001704 putative DNA binding site [nucleotide binding]; other site 423368001705 putative Zn2+ binding site [ion binding]; other site 423368001706 AsnC family; Region: AsnC_trans_reg; pfam01037 423368001707 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 423368001708 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368001709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368001710 Walker A/P-loop; other site 423368001711 ATP binding site [chemical binding]; other site 423368001712 Q-loop/lid; other site 423368001713 ABC transporter signature motif; other site 423368001714 Walker B; other site 423368001715 D-loop; other site 423368001716 H-loop/switch region; other site 423368001717 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 423368001718 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368001719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368001720 Walker A/P-loop; other site 423368001721 ATP binding site [chemical binding]; other site 423368001722 Q-loop/lid; other site 423368001723 ABC transporter signature motif; other site 423368001724 Walker B; other site 423368001725 D-loop; other site 423368001726 H-loop/switch region; other site 423368001727 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 423368001728 Nitrogen regulatory protein P-II; Region: P-II; smart00938 423368001729 ammonium transporter; Provisional; Region: PRK10666 423368001730 acyl-CoA thioesterase II; Provisional; Region: PRK10526 423368001731 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 423368001732 active site 423368001733 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 423368001734 catalytic triad [active] 423368001735 dimer interface [polypeptide binding]; other site 423368001736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 423368001737 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 423368001738 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 423368001739 DNA binding site [nucleotide binding] 423368001740 active site 423368001741 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 423368001742 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 423368001743 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368001744 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 423368001745 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 423368001746 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 423368001747 maltose O-acetyltransferase; Provisional; Region: PRK10092 423368001748 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 423368001749 active site 423368001750 substrate binding site [chemical binding]; other site 423368001751 trimer interface [polypeptide binding]; other site 423368001752 CoA binding site [chemical binding]; other site 423368001753 gene expression modulator; Provisional; Region: PRK10945 423368001754 Hha toxicity attenuator; Provisional; Region: PRK10667 423368001755 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 423368001756 Protein export membrane protein; Region: SecD_SecF; cl14618 423368001757 Protein export membrane protein; Region: SecD_SecF; cl14618 423368001758 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 423368001759 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368001760 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 423368001761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368001762 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 423368001763 hypothetical protein; Provisional; Region: PRK11281 423368001764 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 423368001765 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 423368001766 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368001767 Uncharacterized conserved protein [Function unknown]; Region: COG5464 423368001768 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 423368001769 hypothetical protein; Provisional; Region: PRK11038 423368001770 primosomal replication protein N''; Provisional; Region: PRK10093 423368001771 hypothetical protein; Provisional; Region: PRK10527 423368001772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368001773 active site 423368001774 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 423368001775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368001776 Walker A motif; other site 423368001777 ATP binding site [chemical binding]; other site 423368001778 Walker B motif; other site 423368001779 DNA polymerase III subunit delta'; Validated; Region: PRK08485 423368001780 arginine finger; other site 423368001781 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 423368001782 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 423368001783 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 423368001784 DnaX ribosomal frameshifting element 423368001785 hypothetical protein; Validated; Region: PRK00153 423368001786 recombination protein RecR; Reviewed; Region: recR; PRK00076 423368001787 RecR protein; Region: RecR; pfam02132 423368001788 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 423368001789 putative active site [active] 423368001790 putative metal-binding site [ion binding]; other site 423368001791 tetramer interface [polypeptide binding]; other site 423368001792 heat shock protein 90; Provisional; Region: PRK05218 423368001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368001794 ATP binding site [chemical binding]; other site 423368001795 Mg2+ binding site [ion binding]; other site 423368001796 G-X-G motif; other site 423368001797 adenylate kinase; Reviewed; Region: adk; PRK00279 423368001798 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 423368001799 AMP-binding site [chemical binding]; other site 423368001800 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 423368001801 ferrochelatase; Reviewed; Region: hemH; PRK00035 423368001802 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 423368001803 C-terminal domain interface [polypeptide binding]; other site 423368001804 active site 423368001805 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 423368001806 active site 423368001807 N-terminal domain interface [polypeptide binding]; other site 423368001808 acetyl esterase; Provisional; Region: PRK10162 423368001809 inosine/guanosine kinase; Provisional; Region: PRK15074 423368001810 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368001811 putative cation:proton antiport protein; Provisional; Region: PRK10669 423368001812 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 423368001813 TrkA-N domain; Region: TrkA_N; pfam02254 423368001814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368001816 putative substrate translocation pore; other site 423368001817 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 423368001818 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 423368001819 active site 423368001820 metal binding site [ion binding]; metal-binding site 423368001821 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 423368001822 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 423368001823 putative deacylase active site [active] 423368001824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 423368001825 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 423368001826 copper exporting ATPase; Provisional; Region: copA; PRK10671 423368001827 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368001828 metal-binding site [ion binding] 423368001829 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368001830 metal-binding site [ion binding] 423368001831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 423368001832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368001833 motif II; other site 423368001834 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 423368001835 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 423368001836 DNA binding residues [nucleotide binding] 423368001837 dimer interface [polypeptide binding]; other site 423368001838 copper binding site [ion binding]; other site 423368001839 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 423368001840 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 423368001841 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 423368001842 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 423368001843 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 423368001844 Walker A/P-loop; other site 423368001845 ATP binding site [chemical binding]; other site 423368001846 Q-loop/lid; other site 423368001847 ABC transporter signature motif; other site 423368001848 Walker B; other site 423368001849 D-loop; other site 423368001850 H-loop/switch region; other site 423368001851 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 423368001852 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 423368001853 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 423368001854 oxidoreductase; Provisional; Region: PRK08017 423368001855 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 423368001856 NADP binding site [chemical binding]; other site 423368001857 active site 423368001858 steroid binding site; other site 423368001859 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 423368001860 active site 423368001861 catalytic triad [active] 423368001862 oxyanion hole [active] 423368001863 switch loop; other site 423368001864 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 423368001865 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 423368001866 Walker A/P-loop; other site 423368001867 ATP binding site [chemical binding]; other site 423368001868 Q-loop/lid; other site 423368001869 ABC transporter signature motif; other site 423368001870 Walker B; other site 423368001871 D-loop; other site 423368001872 H-loop/switch region; other site 423368001873 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 423368001874 FtsX-like permease family; Region: FtsX; pfam02687 423368001875 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368001876 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 423368001877 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 423368001878 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 423368001879 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 423368001880 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 423368001881 Walker A/P-loop; other site 423368001882 ATP binding site [chemical binding]; other site 423368001883 Q-loop/lid; other site 423368001884 ABC transporter signature motif; other site 423368001885 Walker B; other site 423368001886 D-loop; other site 423368001887 H-loop/switch region; other site 423368001888 NIL domain; Region: NIL; pfam09383 423368001889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368001890 dimer interface [polypeptide binding]; other site 423368001891 conserved gate region; other site 423368001892 ABC-ATPase subunit interface; other site 423368001893 Predicted ATPase [General function prediction only]; Region: COG2603 423368001894 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 423368001895 active site residue [active] 423368001896 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 423368001897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368001898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368001899 dimerization interface [polypeptide binding]; other site 423368001900 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 423368001901 ureidoglycolate hydrolase; Provisional; Region: PRK03606 423368001902 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 423368001903 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 423368001904 Bacterial transcriptional regulator; Region: IclR; pfam01614 423368001905 glyoxylate carboligase; Provisional; Region: PRK11269 423368001906 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 423368001907 PYR/PP interface [polypeptide binding]; other site 423368001908 dimer interface [polypeptide binding]; other site 423368001909 TPP binding site [chemical binding]; other site 423368001910 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 423368001911 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 423368001912 TPP-binding site [chemical binding]; other site 423368001913 hydroxypyruvate isomerase; Provisional; Region: PRK09997 423368001914 tartronate semialdehyde reductase; Provisional; Region: PRK15059 423368001915 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 423368001916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368001917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368001918 putative substrate translocation pore; other site 423368001919 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 423368001920 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 423368001921 Na binding site [ion binding]; other site 423368001922 putative substrate binding site [chemical binding]; other site 423368001923 allantoinase; Provisional; Region: PRK08044 423368001924 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 423368001925 active site 423368001926 putative uracil/xanthine transporter; Provisional; Region: PRK11412 423368001927 glycerate kinase II; Provisional; Region: PRK09932 423368001928 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 423368001929 Mif2/CENP-C like; Region: Mif2; pfam11699 423368001930 Cupin domain; Region: Cupin_2; pfam07883 423368001931 allantoate amidohydrolase; Region: AllC; TIGR03176 423368001932 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 423368001933 active site 423368001934 metal binding site [ion binding]; metal-binding site 423368001935 dimer interface [polypeptide binding]; other site 423368001936 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 423368001937 membrane protein FdrA; Validated; Region: PRK06091 423368001938 CoA binding domain; Region: CoA_binding; pfam02629 423368001939 CoA-ligase; Region: Ligase_CoA; pfam00549 423368001940 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 423368001941 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 423368001942 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 423368001943 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 423368001944 putative substrate binding site [chemical binding]; other site 423368001945 nucleotide binding site [chemical binding]; other site 423368001946 nucleotide binding site [chemical binding]; other site 423368001947 homodimer interface [polypeptide binding]; other site 423368001948 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 423368001949 ATP-grasp domain; Region: ATP-grasp; pfam02222 423368001950 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 423368001951 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 423368001952 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 423368001953 putative active site [active] 423368001954 putative metal binding site [ion binding]; other site 423368001955 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 423368001956 substrate binding site [chemical binding]; other site 423368001957 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 423368001958 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 423368001959 active site 423368001960 HIGH motif; other site 423368001961 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 423368001962 KMSKS motif; other site 423368001963 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 423368001964 tRNA binding surface [nucleotide binding]; other site 423368001965 anticodon binding site; other site 423368001966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 423368001967 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 423368001968 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 423368001969 ribosome-associated protein; Provisional; Region: PRK11507 423368001970 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 423368001971 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 423368001972 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 423368001973 homodimer interface [polypeptide binding]; other site 423368001974 NADP binding site [chemical binding]; other site 423368001975 substrate binding site [chemical binding]; other site 423368001976 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 423368001977 fimbrial protein FimI; Provisional; Region: PRK15200 423368001978 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 423368001979 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368001980 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368001981 outer membrane usher protein FimD; Provisional; Region: PRK15198 423368001982 PapC N-terminal domain; Region: PapC_N; pfam13954 423368001983 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368001984 PapC C-terminal domain; Region: PapC_C; pfam13953 423368001985 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 423368001986 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 423368001987 transcriptional regulator FimZ; Provisional; Region: PRK09935 423368001988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368001989 active site 423368001990 phosphorylation site [posttranslational modification] 423368001991 intermolecular recognition site; other site 423368001992 dimerization interface [polypeptide binding]; other site 423368001993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368001994 DNA binding residues [nucleotide binding] 423368001995 dimerization interface [polypeptide binding]; other site 423368001996 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 423368001997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368001998 DNA binding residues [nucleotide binding] 423368001999 dimerization interface [polypeptide binding]; other site 423368002000 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 423368002001 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 423368002002 Ligand binding site; other site 423368002003 Putative Catalytic site; other site 423368002004 DXD motif; other site 423368002005 Predicted membrane protein [Function unknown]; Region: COG2246 423368002006 GtrA-like protein; Region: GtrA; pfam04138 423368002007 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 423368002008 Cupin; Region: Cupin_6; pfam12852 423368002009 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 423368002010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368002011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368002012 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 423368002013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368002014 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 423368002015 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368002016 Predicted membrane protein [Function unknown]; Region: COG3059 423368002017 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 423368002018 phenylalanine transporter; Provisional; Region: PRK10249 423368002019 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 423368002020 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368002021 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 423368002022 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 423368002023 active site 423368002024 oxyanion hole [active] 423368002025 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 423368002026 catalytic triad [active] 423368002027 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 423368002028 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 423368002029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368002030 ATP binding site [chemical binding]; other site 423368002031 Walker B motif; other site 423368002032 arginine finger; other site 423368002033 Transcriptional antiterminator [Transcription]; Region: COG3933 423368002034 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368002035 active pocket/dimerization site; other site 423368002036 active site 423368002037 phosphorylation site [posttranslational modification] 423368002038 PRD domain; Region: PRD; pfam00874 423368002039 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 423368002040 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 423368002041 putative active site [active] 423368002042 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 423368002043 dimer interface [polypeptide binding]; other site 423368002044 active site 423368002045 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 423368002046 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 423368002047 dimer interface [polypeptide binding]; other site 423368002048 active site 423368002049 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 423368002050 dimer interface [polypeptide binding]; other site 423368002051 active site 423368002052 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 423368002053 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 423368002054 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 423368002055 active site 423368002056 phosphorylation site [posttranslational modification] 423368002057 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368002058 active pocket/dimerization site; other site 423368002059 active site 423368002060 phosphorylation site [posttranslational modification] 423368002061 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 423368002062 dimer interface [polypeptide binding]; other site 423368002063 FMN binding site [chemical binding]; other site 423368002064 hypothetical protein; Provisional; Region: PRK10250 423368002065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 423368002066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368002067 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 423368002068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368002069 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 423368002070 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 423368002071 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 423368002072 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 423368002073 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 423368002074 outer membrane receptor FepA; Provisional; Region: PRK13524 423368002075 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368002076 N-terminal plug; other site 423368002077 ligand-binding site [chemical binding]; other site 423368002078 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 423368002079 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 423368002080 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 423368002081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 423368002082 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 423368002083 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 423368002084 acyl-activating enzyme (AAE) consensus motif; other site 423368002085 AMP binding site [chemical binding]; other site 423368002086 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 423368002087 LPS O-antigen length regulator; Provisional; Region: PRK10381 423368002088 Chain length determinant protein; Region: Wzz; pfam02706 423368002089 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 423368002090 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 423368002091 Walker A/P-loop; other site 423368002092 ATP binding site [chemical binding]; other site 423368002093 Q-loop/lid; other site 423368002094 ABC transporter signature motif; other site 423368002095 Walker B; other site 423368002096 D-loop; other site 423368002097 H-loop/switch region; other site 423368002098 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 423368002099 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368002100 ABC-ATPase subunit interface; other site 423368002101 dimer interface [polypeptide binding]; other site 423368002102 putative PBP binding regions; other site 423368002103 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 423368002104 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368002105 ABC-ATPase subunit interface; other site 423368002106 dimer interface [polypeptide binding]; other site 423368002107 putative PBP binding regions; other site 423368002108 enterobactin exporter EntS; Provisional; Region: PRK10489 423368002109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368002110 putative substrate translocation pore; other site 423368002111 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 423368002112 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 423368002113 siderophore binding site; other site 423368002114 isochorismate synthase EntC; Provisional; Region: PRK15016 423368002115 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 423368002116 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 423368002117 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 423368002118 acyl-activating enzyme (AAE) consensus motif; other site 423368002119 active site 423368002120 AMP binding site [chemical binding]; other site 423368002121 substrate binding site [chemical binding]; other site 423368002122 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 423368002123 hydrophobic substrate binding pocket; other site 423368002124 Isochorismatase family; Region: Isochorismatase; pfam00857 423368002125 active site 423368002126 conserved cis-peptide bond; other site 423368002127 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 423368002128 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 423368002129 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 423368002130 putative NAD(P) binding site [chemical binding]; other site 423368002131 active site 423368002132 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 423368002133 CoenzymeA binding site [chemical binding]; other site 423368002134 subunit interaction site [polypeptide binding]; other site 423368002135 PHB binding site; other site 423368002136 carbon starvation protein A; Provisional; Region: PRK15015 423368002137 Carbon starvation protein CstA; Region: CstA; pfam02554 423368002138 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 423368002139 Uncharacterized small protein [Function unknown]; Region: COG2879 423368002140 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 423368002141 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 423368002142 putative active site [active] 423368002143 metal binding site [ion binding]; metal-binding site 423368002144 methionine aminotransferase; Validated; Region: PRK09082 423368002145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368002146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368002147 homodimer interface [polypeptide binding]; other site 423368002148 catalytic residue [active] 423368002149 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 423368002150 ParB-like nuclease domain; Region: ParBc; pfam02195 423368002151 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 423368002152 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 423368002153 Active Sites [active] 423368002154 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 423368002155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368002156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368002157 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368002158 dimerization interface [polypeptide binding]; other site 423368002159 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 423368002160 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 423368002161 dimerization domain [polypeptide binding]; other site 423368002162 dimer interface [polypeptide binding]; other site 423368002163 catalytic residues [active] 423368002164 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 423368002165 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 423368002166 dimer interface [polypeptide binding]; other site 423368002167 decamer (pentamer of dimers) interface [polypeptide binding]; other site 423368002168 catalytic triad [active] 423368002169 peroxidatic and resolving cysteines [active] 423368002170 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 423368002171 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 423368002172 catalytic residue [active] 423368002173 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 423368002174 catalytic residues [active] 423368002175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368002176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368002177 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 423368002178 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 423368002179 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 423368002180 putative [4Fe-4S] binding site [ion binding]; other site 423368002181 putative molybdopterin cofactor binding site [chemical binding]; other site 423368002182 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 423368002183 molybdopterin cofactor binding site; other site 423368002184 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 423368002185 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 423368002186 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 423368002187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 423368002188 Ligand Binding Site [chemical binding]; other site 423368002189 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 423368002190 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 423368002191 NAD binding site [chemical binding]; other site 423368002192 catalytic Zn binding site [ion binding]; other site 423368002193 structural Zn binding site [ion binding]; other site 423368002194 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 423368002195 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 423368002196 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 423368002197 B1 nucleotide binding pocket [chemical binding]; other site 423368002198 B2 nucleotide binding pocket [chemical binding]; other site 423368002199 CAS motifs; other site 423368002200 active site 423368002201 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 423368002202 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 423368002203 transmembrane helices; other site 423368002204 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 423368002205 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 423368002206 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 423368002207 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 423368002208 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 423368002209 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 423368002210 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 423368002211 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 423368002212 putative active site [active] 423368002213 (T/H)XGH motif; other site 423368002214 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 423368002215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368002216 putative active site [active] 423368002217 heme pocket [chemical binding]; other site 423368002218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368002219 ATP binding site [chemical binding]; other site 423368002220 Mg2+ binding site [ion binding]; other site 423368002221 G-X-G motif; other site 423368002222 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 423368002223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368002224 active site 423368002225 phosphorylation site [posttranslational modification] 423368002226 intermolecular recognition site; other site 423368002227 dimerization interface [polypeptide binding]; other site 423368002228 Transcriptional regulator; Region: CitT; pfam12431 423368002229 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 423368002230 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 423368002231 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 423368002232 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 423368002233 DNA-binding site [nucleotide binding]; DNA binding site 423368002234 RNA-binding motif; other site 423368002235 chromosome condensation membrane protein; Provisional; Region: PRK14196 423368002236 Predicted amidohydrolase [General function prediction only]; Region: COG0388 423368002237 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 423368002238 putative active site [active] 423368002239 catalytic triad [active] 423368002240 putative dimer interface [polypeptide binding]; other site 423368002241 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 423368002242 lipoyl synthase; Provisional; Region: PRK05481 423368002243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368002244 FeS/SAM binding site; other site 423368002245 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 423368002246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368002247 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 423368002248 substrate binding pocket [chemical binding]; other site 423368002249 dimerization interface [polypeptide binding]; other site 423368002250 lipoate-protein ligase B; Provisional; Region: PRK14342 423368002251 hypothetical protein; Provisional; Region: PRK04998 423368002252 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 423368002253 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 423368002254 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 423368002255 rare lipoprotein A; Provisional; Region: PRK10672 423368002256 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 423368002257 Sporulation related domain; Region: SPOR; pfam05036 423368002258 cell wall shape-determining protein; Provisional; Region: PRK10794 423368002259 penicillin-binding protein 2; Provisional; Region: PRK10795 423368002260 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 423368002261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 423368002262 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 423368002263 ribosome-associated protein; Provisional; Region: PRK11538 423368002264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 423368002265 catalytic core [active] 423368002266 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 423368002267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368002269 homodimer interface [polypeptide binding]; other site 423368002270 catalytic residue [active] 423368002271 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 423368002272 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 423368002273 active site 423368002274 (T/H)XGH motif; other site 423368002275 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 423368002276 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 423368002277 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 423368002278 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 423368002279 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 423368002280 HIGH motif; other site 423368002281 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 423368002282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 423368002283 active site 423368002284 KMSKS motif; other site 423368002285 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 423368002286 tRNA binding surface [nucleotide binding]; other site 423368002287 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 423368002288 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 423368002289 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 423368002290 Propionate catabolism activator; Region: PrpR_N; pfam06506 423368002291 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 423368002292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368002293 Walker A motif; other site 423368002294 ATP binding site [chemical binding]; other site 423368002295 Walker B motif; other site 423368002296 arginine finger; other site 423368002297 hypothetical protein; Provisional; Region: PRK11032 423368002298 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 423368002299 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368002300 Sel1-like repeats; Region: SEL1; smart00671 423368002301 Sel1-like repeats; Region: SEL1; smart00671 423368002302 Sel1-like repeats; Region: SEL1; smart00671 423368002303 Sel1-like repeats; Region: SEL1; smart00671 423368002304 Sel1-like repeats; Region: SEL1; smart00671 423368002305 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 423368002306 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 423368002307 HSP70 interaction site [polypeptide binding]; other site 423368002308 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 423368002309 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 423368002310 HSP70 interaction site [polypeptide binding]; other site 423368002311 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 423368002312 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 423368002313 nucleotide binding site [chemical binding]; other site 423368002314 putative NEF/HSP70 interaction site [polypeptide binding]; other site 423368002315 SBD interface [polypeptide binding]; other site 423368002316 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 423368002317 active site 423368002318 tetramer interface [polypeptide binding]; other site 423368002319 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 423368002320 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 423368002321 Walker A/P-loop; other site 423368002322 ATP binding site [chemical binding]; other site 423368002323 Q-loop/lid; other site 423368002324 ABC transporter signature motif; other site 423368002325 Walker B; other site 423368002326 D-loop; other site 423368002327 H-loop/switch region; other site 423368002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368002329 dimer interface [polypeptide binding]; other site 423368002330 conserved gate region; other site 423368002331 putative PBP binding loops; other site 423368002332 ABC-ATPase subunit interface; other site 423368002333 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368002335 dimer interface [polypeptide binding]; other site 423368002336 conserved gate region; other site 423368002337 putative PBP binding loops; other site 423368002338 ABC-ATPase subunit interface; other site 423368002339 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 423368002340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368002341 substrate binding pocket [chemical binding]; other site 423368002342 membrane-bound complex binding site; other site 423368002343 hinge residues; other site 423368002344 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 423368002345 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 423368002346 putative active site [active] 423368002347 catalytic triad [active] 423368002348 putative dimer interface [polypeptide binding]; other site 423368002349 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 423368002350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 423368002351 Transporter associated domain; Region: CorC_HlyC; smart01091 423368002352 metal-binding heat shock protein; Provisional; Region: PRK00016 423368002353 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 423368002354 PhoH-like protein; Region: PhoH; pfam02562 423368002355 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 423368002356 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 423368002357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368002358 FeS/SAM binding site; other site 423368002359 TRAM domain; Region: TRAM; pfam01938 423368002360 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 423368002361 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 423368002362 asparagine synthetase B; Provisional; Region: asnB; PRK09431 423368002363 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 423368002364 active site 423368002365 dimer interface [polypeptide binding]; other site 423368002366 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 423368002367 Ligand Binding Site [chemical binding]; other site 423368002368 Molecular Tunnel; other site 423368002369 UMP phosphatase; Provisional; Region: PRK10444 423368002370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002371 active site 423368002372 motif I; other site 423368002373 motif II; other site 423368002374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002375 MarR family; Region: MarR; pfam01047 423368002376 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 423368002377 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368002378 nucleotide binding site [chemical binding]; other site 423368002379 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 423368002380 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 423368002381 active site 423368002382 dimer interface [polypeptide binding]; other site 423368002383 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 423368002384 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 423368002385 active site 423368002386 trimer interface [polypeptide binding]; other site 423368002387 allosteric site; other site 423368002388 active site lid [active] 423368002389 hexamer (dimer of trimers) interface [polypeptide binding]; other site 423368002390 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 423368002391 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 423368002392 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 423368002393 active site turn [active] 423368002394 phosphorylation site [posttranslational modification] 423368002395 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 423368002396 HPr interaction site; other site 423368002397 glycerol kinase (GK) interaction site [polypeptide binding]; other site 423368002398 active site 423368002399 phosphorylation site [posttranslational modification] 423368002400 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 423368002401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 423368002402 active site 423368002403 HIGH motif; other site 423368002404 nucleotide binding site [chemical binding]; other site 423368002405 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 423368002406 KMSKS motif; other site 423368002407 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 423368002408 outer membrane porin, OprD family; Region: OprD; pfam03573 423368002409 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 423368002410 YbfN-like lipoprotein; Region: YbfN; pfam13982 423368002411 citrate-proton symporter; Provisional; Region: PRK15075 423368002412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368002413 putative substrate translocation pore; other site 423368002414 tricarballylate utilization protein B; Provisional; Region: PRK15033 423368002415 tricarballylate dehydrogenase; Validated; Region: PRK08274 423368002416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368002417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368002418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368002419 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 423368002420 putative dimerization interface [polypeptide binding]; other site 423368002421 ferric uptake regulator; Provisional; Region: fur; PRK09462 423368002422 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 423368002423 metal binding site 2 [ion binding]; metal-binding site 423368002424 putative DNA binding helix; other site 423368002425 metal binding site 1 [ion binding]; metal-binding site 423368002426 dimer interface [polypeptide binding]; other site 423368002427 structural Zn2+ binding site [ion binding]; other site 423368002428 flavodoxin FldA; Validated; Region: PRK09267 423368002429 LexA regulated protein; Provisional; Region: PRK11675 423368002430 acyl-CoA esterase; Provisional; Region: PRK10673 423368002431 PGAP1-like protein; Region: PGAP1; pfam07819 423368002432 replication initiation regulator SeqA; Provisional; Region: PRK11187 423368002433 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 423368002434 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 423368002435 active site 423368002436 substrate binding site [chemical binding]; other site 423368002437 metal binding site [ion binding]; metal-binding site 423368002438 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 423368002439 putrescine transporter; Provisional; Region: potE; PRK10655 423368002440 ornithine decarboxylase; Provisional; Region: PRK13578 423368002441 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 423368002442 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 423368002443 homodimer interface [polypeptide binding]; other site 423368002444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368002445 catalytic residue [active] 423368002446 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 423368002447 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 423368002448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368002449 active site 423368002450 phosphorylation site [posttranslational modification] 423368002451 intermolecular recognition site; other site 423368002452 dimerization interface [polypeptide binding]; other site 423368002453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368002454 DNA binding site [nucleotide binding] 423368002455 sensor protein KdpD; Provisional; Region: PRK10490 423368002456 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 423368002457 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 423368002458 Ligand Binding Site [chemical binding]; other site 423368002459 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 423368002460 GAF domain; Region: GAF_3; pfam13492 423368002461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368002462 dimer interface [polypeptide binding]; other site 423368002463 phosphorylation site [posttranslational modification] 423368002464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368002465 ATP binding site [chemical binding]; other site 423368002466 Mg2+ binding site [ion binding]; other site 423368002467 G-X-G motif; other site 423368002468 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 423368002469 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 423368002470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 423368002471 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 423368002472 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 423368002473 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 423368002474 DNA photolyase; Region: DNA_photolyase; pfam00875 423368002475 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 423368002476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368002477 putative substrate translocation pore; other site 423368002478 POT family; Region: PTR2; pfam00854 423368002479 Uncharacterized conserved protein [Function unknown]; Region: COG0327 423368002480 metal-binding protein; Provisional; Region: PRK10799 423368002481 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 423368002482 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 423368002483 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 423368002484 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 423368002485 putative active site [active] 423368002486 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368002487 active site 423368002488 DNA binding site [nucleotide binding] 423368002489 Int/Topo IB signature motif; other site 423368002490 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 423368002491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 423368002492 UDP-galactopyranose mutase; Region: GLF; pfam03275 423368002493 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 423368002494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 423368002495 active site 423368002496 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 423368002497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 423368002498 putative ADP-binding pocket [chemical binding]; other site 423368002499 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 423368002500 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 423368002501 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 423368002502 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 423368002503 Walker A/P-loop; other site 423368002504 ATP binding site [chemical binding]; other site 423368002505 Q-loop/lid; other site 423368002506 ABC transporter signature motif; other site 423368002507 Walker B; other site 423368002508 D-loop; other site 423368002509 H-loop/switch region; other site 423368002510 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 423368002511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 423368002512 active site 423368002513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 423368002514 active site 423368002515 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 423368002516 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 423368002517 endonuclease VIII; Provisional; Region: PRK10445 423368002518 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 423368002519 DNA binding site [nucleotide binding] 423368002520 catalytic residue [active] 423368002521 putative catalytic residues [active] 423368002522 H2TH interface [polypeptide binding]; other site 423368002523 intercalation triad [nucleotide binding]; other site 423368002524 substrate specificity determining residue; other site 423368002525 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 423368002526 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 423368002527 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 423368002528 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 423368002529 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 423368002530 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 423368002531 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 423368002532 dimer interface [polypeptide binding]; other site 423368002533 active site 423368002534 citrylCoA binding site [chemical binding]; other site 423368002535 NADH binding [chemical binding]; other site 423368002536 cationic pore residues; other site 423368002537 oxalacetate/citrate binding site [chemical binding]; other site 423368002538 coenzyme A binding site [chemical binding]; other site 423368002539 catalytic triad [active] 423368002540 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 423368002541 Iron-sulfur protein interface; other site 423368002542 proximal quinone binding site [chemical binding]; other site 423368002543 SdhD (CybS) interface [polypeptide binding]; other site 423368002544 proximal heme binding site [chemical binding]; other site 423368002545 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 423368002546 SdhC subunit interface [polypeptide binding]; other site 423368002547 proximal heme binding site [chemical binding]; other site 423368002548 cardiolipin binding site; other site 423368002549 Iron-sulfur protein interface; other site 423368002550 proximal quinone binding site [chemical binding]; other site 423368002551 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 423368002552 L-aspartate oxidase; Provisional; Region: PRK06175 423368002553 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 423368002554 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 423368002555 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 423368002556 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 423368002557 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 423368002558 TPP-binding site [chemical binding]; other site 423368002559 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 423368002560 dimer interface [polypeptide binding]; other site 423368002561 PYR/PP interface [polypeptide binding]; other site 423368002562 TPP binding site [chemical binding]; other site 423368002563 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 423368002564 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 423368002565 E3 interaction surface; other site 423368002566 lipoyl attachment site [posttranslational modification]; other site 423368002567 e3 binding domain; Region: E3_binding; pfam02817 423368002568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 423368002569 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 423368002570 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 423368002571 CoA-ligase; Region: Ligase_CoA; pfam00549 423368002572 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 423368002573 CoA binding domain; Region: CoA_binding; smart00881 423368002574 CoA-ligase; Region: Ligase_CoA; pfam00549 423368002575 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 423368002576 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 423368002577 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 423368002578 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 423368002579 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 423368002580 hypothetical protein; Provisional; Region: PRK10588 423368002581 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 423368002582 active site 423368002583 colicin uptake protein TolQ; Provisional; Region: PRK10801 423368002584 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 423368002585 colicin uptake protein TolR; Provisional; Region: PRK11024 423368002586 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 423368002587 TolA C-terminal; Region: TolA; pfam06519 423368002588 translocation protein TolB; Provisional; Region: tolB; PRK03629 423368002589 TolB amino-terminal domain; Region: TolB_N; pfam04052 423368002590 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 423368002591 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 423368002592 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 423368002593 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 423368002594 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 423368002595 ligand binding site [chemical binding]; other site 423368002596 tol-pal system protein YbgF; Provisional; Region: PRK10803 423368002597 Tetratricopeptide repeat; Region: TPR_6; pfam13174 423368002598 Tetratricopeptide repeat; Region: TPR_6; pfam13174 423368002599 quinolinate synthetase; Provisional; Region: PRK09375 423368002600 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 423368002601 zinc transporter ZitB; Provisional; Region: PRK03557 423368002602 YbgS-like protein; Region: YbgS; pfam13985 423368002603 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 423368002604 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 423368002605 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 423368002606 fumarate hydratase; Provisional; Region: PRK06246 423368002607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368002608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368002609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368002610 dimerization interface [polypeptide binding]; other site 423368002611 cell density-dependent motility repressor; Provisional; Region: PRK10082 423368002612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368002613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368002614 dimerization interface [polypeptide binding]; other site 423368002615 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 423368002616 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 423368002617 transmembrane helices; other site 423368002618 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 423368002619 oxaloacetate decarboxylase; Provisional; Region: PRK14040 423368002620 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 423368002621 active site 423368002622 catalytic residues [active] 423368002623 metal binding site [ion binding]; metal-binding site 423368002624 homodimer binding site [polypeptide binding]; other site 423368002625 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 423368002626 carboxyltransferase (CT) interaction site; other site 423368002627 biotinylation site [posttranslational modification]; other site 423368002628 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 423368002629 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 423368002630 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 423368002631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368002632 dimer interface [polypeptide binding]; other site 423368002633 putative PBP binding regions; other site 423368002634 ABC-ATPase subunit interface; other site 423368002635 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 423368002636 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 423368002637 Walker A/P-loop; other site 423368002638 ATP binding site [chemical binding]; other site 423368002639 Q-loop/lid; other site 423368002640 ABC transporter signature motif; other site 423368002641 Walker B; other site 423368002642 D-loop; other site 423368002643 H-loop/switch region; other site 423368002644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 423368002645 catalytic core [active] 423368002646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 423368002647 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 423368002648 active site 423368002649 catalytic residues [active] 423368002650 galactokinase; Provisional; Region: PRK05101 423368002651 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 423368002652 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 423368002653 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 423368002654 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 423368002655 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 423368002656 dimer interface [polypeptide binding]; other site 423368002657 active site 423368002658 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 423368002659 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 423368002660 NAD binding site [chemical binding]; other site 423368002661 homodimer interface [polypeptide binding]; other site 423368002662 active site 423368002663 substrate binding site [chemical binding]; other site 423368002664 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 423368002665 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 423368002666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368002667 Walker A/P-loop; other site 423368002668 ATP binding site [chemical binding]; other site 423368002669 Q-loop/lid; other site 423368002670 ABC transporter signature motif; other site 423368002671 Walker B; other site 423368002672 D-loop; other site 423368002673 H-loop/switch region; other site 423368002674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368002675 Walker A/P-loop; other site 423368002676 ATP binding site [chemical binding]; other site 423368002677 Q-loop/lid; other site 423368002678 ABC transporter signature motif; other site 423368002679 Walker B; other site 423368002680 D-loop; other site 423368002681 H-loop/switch region; other site 423368002682 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 423368002683 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 423368002684 molybdenum-pterin binding domain; Region: Mop; TIGR00638 423368002685 TOBE domain; Region: TOBE; pfam03459 423368002686 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 423368002687 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 423368002688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368002689 substrate binding pocket [chemical binding]; other site 423368002690 membrane-bound complex binding site; other site 423368002691 hinge residues; other site 423368002692 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 423368002693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368002694 dimer interface [polypeptide binding]; other site 423368002695 conserved gate region; other site 423368002696 putative PBP binding loops; other site 423368002697 ABC-ATPase subunit interface; other site 423368002698 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 423368002699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368002700 Walker A/P-loop; other site 423368002701 ATP binding site [chemical binding]; other site 423368002702 Q-loop/lid; other site 423368002703 ABC transporter signature motif; other site 423368002704 Walker B; other site 423368002705 D-loop; other site 423368002706 H-loop/switch region; other site 423368002707 molybdenum-pterin binding domain; Region: Mop; TIGR00638 423368002708 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 423368002709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002710 active site 423368002711 motif I; other site 423368002712 motif II; other site 423368002713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002714 6-phosphogluconolactonase; Provisional; Region: PRK11028 423368002715 acyl-CoA thioesterase; Provisional; Region: PRK10531 423368002716 putative pectinesterase; Region: PLN02432; cl01911 423368002717 imidazolonepropionase; Validated; Region: PRK09356 423368002718 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 423368002719 active site 423368002720 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 423368002721 putative active site [active] 423368002722 putative metal binding site [ion binding]; other site 423368002723 histidine utilization repressor; Provisional; Region: PRK14999 423368002724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368002725 DNA-binding site [nucleotide binding]; DNA binding site 423368002726 UTRA domain; Region: UTRA; pfam07702 423368002727 urocanate hydratase; Provisional; Region: PRK05414 423368002728 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 423368002729 active sites [active] 423368002730 tetramer interface [polypeptide binding]; other site 423368002731 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 423368002732 substrate binding site [chemical binding]; other site 423368002733 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 423368002734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 423368002735 inhibitor-cofactor binding pocket; inhibition site 423368002736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368002737 catalytic residue [active] 423368002738 biotin synthase; Provisional; Region: PRK15108 423368002739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368002740 FeS/SAM binding site; other site 423368002741 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 423368002742 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 423368002743 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 423368002744 substrate-cofactor binding pocket; other site 423368002745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368002746 catalytic residue [active] 423368002747 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 423368002748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368002749 S-adenosylmethionine binding site [chemical binding]; other site 423368002750 AAA domain; Region: AAA_26; pfam13500 423368002751 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 423368002752 excinuclease ABC subunit B; Provisional; Region: PRK05298 423368002753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368002754 ATP binding site [chemical binding]; other site 423368002755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368002756 nucleotide binding region [chemical binding]; other site 423368002757 ATP-binding site [chemical binding]; other site 423368002758 Ultra-violet resistance protein B; Region: UvrB; pfam12344 423368002759 UvrB/uvrC motif; Region: UVR; pfam02151 423368002760 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 423368002761 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 423368002762 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 423368002763 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 423368002764 Leucine-rich repeats; other site 423368002765 Substrate binding site [chemical binding]; other site 423368002766 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 423368002767 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 423368002768 putative substrate binding pocket [chemical binding]; other site 423368002769 dimer interface [polypeptide binding]; other site 423368002770 phosphate binding site [ion binding]; other site 423368002771 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 423368002772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368002773 FeS/SAM binding site; other site 423368002774 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 423368002775 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 423368002776 MPT binding site; other site 423368002777 trimer interface [polypeptide binding]; other site 423368002778 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 423368002779 trimer interface [polypeptide binding]; other site 423368002780 dimer interface [polypeptide binding]; other site 423368002781 putative active site [active] 423368002782 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 423368002783 MoaE interaction surface [polypeptide binding]; other site 423368002784 MoeB interaction surface [polypeptide binding]; other site 423368002785 thiocarboxylated glycine; other site 423368002786 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 423368002787 MoaE homodimer interface [polypeptide binding]; other site 423368002788 MoaD interaction [polypeptide binding]; other site 423368002789 active site residues [active] 423368002790 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 423368002791 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 423368002792 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 423368002793 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 423368002794 Predicted integral membrane protein [Function unknown]; Region: COG0392 423368002795 cardiolipin synthase 2; Provisional; Region: PRK11263 423368002796 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 423368002797 putative active site [active] 423368002798 catalytic site [active] 423368002799 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 423368002800 putative active site [active] 423368002801 catalytic site [active] 423368002802 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 423368002803 putative catalytic site [active] 423368002804 putative metal binding site [ion binding]; other site 423368002805 putative phosphate binding site [ion binding]; other site 423368002806 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 423368002807 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 423368002808 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 423368002809 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 423368002810 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 423368002811 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 423368002812 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 423368002813 Walker A/P-loop; other site 423368002814 ATP binding site [chemical binding]; other site 423368002815 Q-loop/lid; other site 423368002816 ABC transporter signature motif; other site 423368002817 Walker B; other site 423368002818 D-loop; other site 423368002819 H-loop/switch region; other site 423368002820 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 423368002821 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 423368002822 Walker A/P-loop; other site 423368002823 ATP binding site [chemical binding]; other site 423368002824 Q-loop/lid; other site 423368002825 ABC transporter signature motif; other site 423368002826 Walker B; other site 423368002827 D-loop; other site 423368002828 H-loop/switch region; other site 423368002829 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 423368002830 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368002831 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368002832 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 423368002833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368002834 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 423368002835 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 423368002836 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 423368002837 ATP binding site [chemical binding]; other site 423368002838 Mg++ binding site [ion binding]; other site 423368002839 motif III; other site 423368002840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368002841 nucleotide binding region [chemical binding]; other site 423368002842 ATP-binding site [chemical binding]; other site 423368002843 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 423368002844 DEAD_2; Region: DEAD_2; pfam06733 423368002845 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 423368002846 glycosyl transferase family protein; Provisional; Region: PRK08136 423368002847 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 423368002848 hypothetical protein; Provisional; Region: PRK10259 423368002849 hypothetical protein; Provisional; Region: PRK11019 423368002850 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 423368002851 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 423368002852 putative mechanosensitive channel protein; Provisional; Region: PRK11465 423368002853 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368002854 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 423368002855 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 423368002856 Walker A/P-loop; other site 423368002857 ATP binding site [chemical binding]; other site 423368002858 Q-loop/lid; other site 423368002859 ABC transporter signature motif; other site 423368002860 Walker B; other site 423368002861 D-loop; other site 423368002862 H-loop/switch region; other site 423368002863 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368002864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368002865 dimer interface [polypeptide binding]; other site 423368002866 conserved gate region; other site 423368002867 putative PBP binding loops; other site 423368002868 ABC-ATPase subunit interface; other site 423368002869 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 423368002870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368002871 substrate binding pocket [chemical binding]; other site 423368002872 membrane-bound complex binding site; other site 423368002873 hinge residues; other site 423368002874 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 423368002875 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 423368002876 dimerization interface [polypeptide binding]; other site 423368002877 DPS ferroxidase diiron center [ion binding]; other site 423368002878 ion pore; other site 423368002879 threonine and homoserine efflux system; Provisional; Region: PRK10532 423368002880 EamA-like transporter family; Region: EamA; pfam00892 423368002881 outer membrane protein X; Provisional; Region: ompX; PRK09408 423368002882 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 423368002883 Sulfatase; Region: Sulfatase; pfam00884 423368002884 manganese transport regulator MntR; Provisional; Region: PRK11050 423368002885 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 423368002886 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 423368002887 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 423368002888 transmembrane helices; other site 423368002889 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 423368002890 L,D-transpeptidase; Provisional; Region: PRK10260 423368002891 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368002892 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 423368002893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368002894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368002895 Walker A/P-loop; other site 423368002896 ATP binding site [chemical binding]; other site 423368002897 ABC transporter signature motif; other site 423368002898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368002899 Walker B; other site 423368002900 ABC transporter; Region: ABC_tran_2; pfam12848 423368002901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368002902 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 423368002903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002904 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 423368002905 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 423368002906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002907 active site 423368002908 motif I; other site 423368002909 motif II; other site 423368002910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368002911 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 423368002912 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 423368002913 dimer interface [polypeptide binding]; other site 423368002914 active site 423368002915 glycine loop; other site 423368002916 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 423368002917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368002918 FeS/SAM binding site; other site 423368002919 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 423368002920 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 423368002921 ATP binding site [chemical binding]; other site 423368002922 substrate interface [chemical binding]; other site 423368002923 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 423368002924 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 423368002925 dimer interface [polypeptide binding]; other site 423368002926 putative functional site; other site 423368002927 putative MPT binding site; other site 423368002928 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 423368002929 catalytic nucleophile [active] 423368002930 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 423368002931 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368002932 Walker A/P-loop; other site 423368002933 ATP binding site [chemical binding]; other site 423368002934 Q-loop/lid; other site 423368002935 ABC transporter signature motif; other site 423368002936 Walker B; other site 423368002937 D-loop; other site 423368002938 H-loop/switch region; other site 423368002939 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 423368002940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368002941 Walker A/P-loop; other site 423368002942 ATP binding site [chemical binding]; other site 423368002943 Q-loop/lid; other site 423368002944 ABC transporter signature motif; other site 423368002945 Walker B; other site 423368002946 D-loop; other site 423368002947 H-loop/switch region; other site 423368002948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 423368002949 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 423368002950 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 423368002951 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 423368002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368002953 dimer interface [polypeptide binding]; other site 423368002954 conserved gate region; other site 423368002955 putative PBP binding loops; other site 423368002956 ABC-ATPase subunit interface; other site 423368002957 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 423368002958 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 423368002959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368002960 dimer interface [polypeptide binding]; other site 423368002961 conserved gate region; other site 423368002962 putative PBP binding loops; other site 423368002963 ABC-ATPase subunit interface; other site 423368002964 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 423368002965 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 423368002966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368002967 FeS/SAM binding site; other site 423368002968 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 423368002969 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 423368002970 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 423368002971 Ligand binding site [chemical binding]; other site 423368002972 Electron transfer flavoprotein domain; Region: ETF; pfam01012 423368002973 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 423368002974 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 423368002975 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 423368002976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 423368002977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 423368002978 active site 423368002979 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 423368002980 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368002981 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 423368002982 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 423368002983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368002984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368002985 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 423368002986 putative dimerization interface [polypeptide binding]; other site 423368002987 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 423368002988 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 423368002989 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 423368002990 putative C-terminal domain interface [polypeptide binding]; other site 423368002991 putative GSH binding site (G-site) [chemical binding]; other site 423368002992 putative dimer interface [polypeptide binding]; other site 423368002993 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 423368002994 putative N-terminal domain interface [polypeptide binding]; other site 423368002995 putative dimer interface [polypeptide binding]; other site 423368002996 putative substrate binding pocket (H-site) [chemical binding]; other site 423368002997 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 423368002998 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 423368002999 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 423368003000 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 423368003001 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 423368003002 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368003003 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 423368003004 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 423368003005 active site 423368003006 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 423368003007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003008 putative substrate translocation pore; other site 423368003009 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 423368003010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368003011 active site 423368003012 motif I; other site 423368003013 motif II; other site 423368003014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368003015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003016 putative substrate translocation pore; other site 423368003017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368003018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 423368003019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368003020 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 423368003021 putative transporter; Provisional; Region: PRK04972 423368003022 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 423368003023 TrkA-C domain; Region: TrkA_C; pfam02080 423368003024 TrkA-C domain; Region: TrkA_C; pfam02080 423368003025 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 423368003026 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 423368003027 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 423368003028 GSH binding site [chemical binding]; other site 423368003029 catalytic residues [active] 423368003030 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 423368003031 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 423368003032 dimer interface [polypeptide binding]; other site 423368003033 FMN binding site [chemical binding]; other site 423368003034 NADPH bind site [chemical binding]; other site 423368003035 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 423368003036 RimK-like ATP-grasp domain; Region: RimK; pfam08443 423368003037 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 423368003038 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 423368003039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 423368003040 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 423368003041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003042 Walker A/P-loop; other site 423368003043 ATP binding site [chemical binding]; other site 423368003044 Q-loop/lid; other site 423368003045 ABC transporter signature motif; other site 423368003046 Walker B; other site 423368003047 D-loop; other site 423368003048 H-loop/switch region; other site 423368003049 TOBE domain; Region: TOBE_2; pfam08402 423368003050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368003051 dimer interface [polypeptide binding]; other site 423368003052 conserved gate region; other site 423368003053 putative PBP binding loops; other site 423368003054 ABC-ATPase subunit interface; other site 423368003055 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 423368003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368003057 dimer interface [polypeptide binding]; other site 423368003058 conserved gate region; other site 423368003059 putative PBP binding loops; other site 423368003060 ABC-ATPase subunit interface; other site 423368003061 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 423368003062 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 423368003063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368003064 S-adenosylmethionine binding site [chemical binding]; other site 423368003065 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 423368003066 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 423368003067 active site 423368003068 P-loop; other site 423368003069 phosphorylation site [posttranslational modification] 423368003070 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 423368003071 Sulfatase; Region: Sulfatase; cl17466 423368003072 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 423368003073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368003074 substrate binding pocket [chemical binding]; other site 423368003075 membrane-bound complex binding site; other site 423368003076 hinge residues; other site 423368003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368003078 dimer interface [polypeptide binding]; other site 423368003079 conserved gate region; other site 423368003080 putative PBP binding loops; other site 423368003081 ABC-ATPase subunit interface; other site 423368003082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368003084 dimer interface [polypeptide binding]; other site 423368003085 conserved gate region; other site 423368003086 putative PBP binding loops; other site 423368003087 ABC-ATPase subunit interface; other site 423368003088 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 423368003089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368003090 substrate binding pocket [chemical binding]; other site 423368003091 membrane-bound complex binding site; other site 423368003092 hinge residues; other site 423368003093 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 423368003094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003095 Walker A/P-loop; other site 423368003096 ATP binding site [chemical binding]; other site 423368003097 Q-loop/lid; other site 423368003098 ABC transporter signature motif; other site 423368003099 Walker B; other site 423368003100 D-loop; other site 423368003101 H-loop/switch region; other site 423368003102 putative lipoprotein; Provisional; Region: PRK10533 423368003103 hypothetical protein; Provisional; Region: PRK02877 423368003104 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 423368003105 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 423368003106 amidase catalytic site [active] 423368003107 Zn binding residues [ion binding]; other site 423368003108 substrate binding site [chemical binding]; other site 423368003109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 423368003110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 423368003111 NAD(P) binding site [chemical binding]; other site 423368003112 active site 423368003113 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 423368003114 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 423368003115 putative NAD(P) binding site [chemical binding]; other site 423368003116 putative active site [active] 423368003117 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 423368003118 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 423368003119 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 423368003120 tetramer interface [polypeptide binding]; other site 423368003121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368003122 catalytic residue [active] 423368003123 pyruvate dehydrogenase; Provisional; Region: PRK09124 423368003124 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 423368003125 PYR/PP interface [polypeptide binding]; other site 423368003126 dimer interface [polypeptide binding]; other site 423368003127 tetramer interface [polypeptide binding]; other site 423368003128 TPP binding site [chemical binding]; other site 423368003129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 423368003130 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 423368003131 TPP-binding site [chemical binding]; other site 423368003132 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 423368003133 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 423368003134 FAD binding pocket [chemical binding]; other site 423368003135 FAD binding motif [chemical binding]; other site 423368003136 phosphate binding motif [ion binding]; other site 423368003137 beta-alpha-beta structure motif; other site 423368003138 NAD binding pocket [chemical binding]; other site 423368003139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 423368003140 catalytic loop [active] 423368003141 iron binding site [ion binding]; other site 423368003142 hybrid cluster protein; Provisional; Region: PRK05290 423368003143 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368003144 ACS interaction site; other site 423368003145 CODH interaction site; other site 423368003146 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 423368003147 hybrid metal cluster; other site 423368003148 Predicted membrane protein [Function unknown]; Region: COG2431 423368003149 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 423368003150 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 423368003151 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 423368003152 putative active site [active] 423368003153 putative metal-binding site [ion binding]; other site 423368003154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 423368003155 macrolide transporter subunit MacA; Provisional; Region: PRK11578 423368003156 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368003157 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368003158 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 423368003159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 423368003160 Walker A/P-loop; other site 423368003161 ATP binding site [chemical binding]; other site 423368003162 Q-loop/lid; other site 423368003163 ABC transporter signature motif; other site 423368003164 Walker B; other site 423368003165 D-loop; other site 423368003166 H-loop/switch region; other site 423368003167 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 423368003168 FtsX-like permease family; Region: FtsX; pfam02687 423368003169 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 423368003170 DNA-binding site [nucleotide binding]; DNA binding site 423368003171 RNA-binding motif; other site 423368003172 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 423368003173 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 423368003174 Clp amino terminal domain; Region: Clp_N; pfam02861 423368003175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368003176 Walker A motif; other site 423368003177 ATP binding site [chemical binding]; other site 423368003178 Walker B motif; other site 423368003179 arginine finger; other site 423368003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368003181 Walker A motif; other site 423368003182 ATP binding site [chemical binding]; other site 423368003183 Walker B motif; other site 423368003184 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 423368003185 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368003186 DNA binding site [nucleotide binding] 423368003187 active site 423368003188 Int/Topo IB signature motif; other site 423368003189 Isochorismatase family; Region: Isochorismatase; pfam00857 423368003190 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 423368003191 catalytic triad [active] 423368003192 dimer interface [polypeptide binding]; other site 423368003193 conserved cis-peptide bond; other site 423368003194 Pirin-related protein [General function prediction only]; Region: COG1741 423368003195 Pirin; Region: Pirin; pfam02678 423368003196 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 423368003197 LysR family transcriptional regulator; Provisional; Region: PRK14997 423368003198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368003199 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 423368003200 putative effector binding pocket; other site 423368003201 putative dimerization interface [polypeptide binding]; other site 423368003202 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 423368003203 rRNA binding site [nucleotide binding]; other site 423368003204 predicted 30S ribosome binding site; other site 423368003205 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 423368003206 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 423368003207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368003208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003209 Walker A/P-loop; other site 423368003210 ATP binding site [chemical binding]; other site 423368003211 Q-loop/lid; other site 423368003212 ABC transporter signature motif; other site 423368003213 Walker B; other site 423368003214 D-loop; other site 423368003215 H-loop/switch region; other site 423368003216 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 423368003217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368003218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003219 Walker A/P-loop; other site 423368003220 ATP binding site [chemical binding]; other site 423368003221 Q-loop/lid; other site 423368003222 ABC transporter signature motif; other site 423368003223 Walker B; other site 423368003224 D-loop; other site 423368003225 H-loop/switch region; other site 423368003226 thioredoxin reductase; Provisional; Region: PRK10262 423368003227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368003228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368003229 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 423368003230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368003231 putative DNA binding site [nucleotide binding]; other site 423368003232 putative Zn2+ binding site [ion binding]; other site 423368003233 AsnC family; Region: AsnC_trans_reg; pfam01037 423368003234 DNA translocase FtsK; Provisional; Region: PRK10263 423368003235 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 423368003236 DNA translocase FtsK; Provisional; Region: PRK10263 423368003237 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 423368003238 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 423368003239 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 423368003240 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 423368003241 recombination factor protein RarA; Reviewed; Region: PRK13342 423368003242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368003243 Walker A motif; other site 423368003244 ATP binding site [chemical binding]; other site 423368003245 Walker B motif; other site 423368003246 arginine finger; other site 423368003247 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 423368003248 seryl-tRNA synthetase; Provisional; Region: PRK05431 423368003249 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 423368003250 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 423368003251 dimer interface [polypeptide binding]; other site 423368003252 active site 423368003253 motif 1; other site 423368003254 motif 2; other site 423368003255 motif 3; other site 423368003256 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 423368003257 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 423368003258 putative [Fe4-S4] binding site [ion binding]; other site 423368003259 putative molybdopterin cofactor binding site [chemical binding]; other site 423368003260 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 423368003261 putative molybdopterin cofactor binding site; other site 423368003262 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 423368003263 4Fe-4S binding domain; Region: Fer4; pfam00037 423368003264 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 423368003265 putative MFS family transporter protein; Provisional; Region: PRK03633 423368003266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003267 putative substrate translocation pore; other site 423368003268 inner membrane transporter YjeM; Provisional; Region: PRK15238 423368003269 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 423368003270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368003271 FeS/SAM binding site; other site 423368003272 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 423368003273 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 423368003274 Pyruvate formate lyase 1; Region: PFL1; cd01678 423368003275 coenzyme A binding site [chemical binding]; other site 423368003276 active site 423368003277 catalytic residues [active] 423368003278 glycine loop; other site 423368003279 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 423368003280 uncharacterized domain; Region: TIGR00702 423368003281 YcaO-like family; Region: YcaO; pfam02624 423368003282 Predicted membrane protein [Function unknown]; Region: COG2323 423368003283 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 423368003284 homodimer interface [polypeptide binding]; other site 423368003285 substrate-cofactor binding pocket; other site 423368003286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368003287 catalytic residue [active] 423368003288 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 423368003289 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 423368003290 hinge; other site 423368003291 active site 423368003292 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 423368003293 cytidylate kinase; Provisional; Region: cmk; PRK00023 423368003294 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 423368003295 CMP-binding site; other site 423368003296 The sites determining sugar specificity; other site 423368003297 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 423368003298 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 423368003299 RNA binding site [nucleotide binding]; other site 423368003300 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 423368003301 RNA binding site [nucleotide binding]; other site 423368003302 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 423368003303 RNA binding site [nucleotide binding]; other site 423368003304 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 423368003305 RNA binding site [nucleotide binding]; other site 423368003306 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 423368003307 RNA binding site [nucleotide binding]; other site 423368003308 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 423368003309 IHF dimer interface [polypeptide binding]; other site 423368003310 IHF - DNA interface [nucleotide binding]; other site 423368003311 ComEC family competence protein; Provisional; Region: PRK11539 423368003312 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 423368003313 Competence protein; Region: Competence; pfam03772 423368003314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 423368003315 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 423368003316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368003317 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 423368003318 Walker A/P-loop; other site 423368003319 ATP binding site [chemical binding]; other site 423368003320 Q-loop/lid; other site 423368003321 ABC transporter signature motif; other site 423368003322 Walker B; other site 423368003323 D-loop; other site 423368003324 H-loop/switch region; other site 423368003325 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 423368003326 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 423368003327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 423368003328 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 423368003329 hypothetical protein; Provisional; Region: PRK11827 423368003330 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 423368003331 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 423368003332 Ligand binding site; other site 423368003333 oligomer interface; other site 423368003334 hypothetical protein; Provisional; Region: PRK10593 423368003335 Uncharacterized conserved protein [Function unknown]; Region: COG1434 423368003336 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 423368003337 putative active site [active] 423368003338 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 423368003339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368003340 S-adenosylmethionine binding site [chemical binding]; other site 423368003341 condesin subunit F; Provisional; Region: PRK05260 423368003342 condesin subunit E; Provisional; Region: PRK05256 423368003343 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 423368003344 P-loop containing region of AAA domain; Region: AAA_29; cl17516 423368003345 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 423368003346 murein L,D-transpeptidase; Provisional; Region: PRK10594 423368003347 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 423368003348 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368003349 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368003350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 423368003351 Peptidase M15; Region: Peptidase_M15_3; cl01194 423368003352 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 423368003353 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 423368003354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368003355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368003356 homodimer interface [polypeptide binding]; other site 423368003357 catalytic residue [active] 423368003358 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368003359 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368003360 trimer interface [polypeptide binding]; other site 423368003361 eyelet of channel; other site 423368003362 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 423368003363 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 423368003364 putative dimer interface [polypeptide binding]; other site 423368003365 putative anticodon binding site; other site 423368003366 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 423368003367 homodimer interface [polypeptide binding]; other site 423368003368 motif 1; other site 423368003369 motif 2; other site 423368003370 active site 423368003371 motif 3; other site 423368003372 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 423368003373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368003374 putative DNA binding site [nucleotide binding]; other site 423368003375 putative Zn2+ binding site [ion binding]; other site 423368003376 AsnC family; Region: AsnC_trans_reg; pfam01037 423368003377 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 423368003378 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 423368003379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368003380 catalytic residue [active] 423368003381 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 423368003382 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 423368003383 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 423368003384 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 423368003385 active site 423368003386 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 423368003387 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 423368003388 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 423368003389 Int/Topo IB signature motif; other site 423368003390 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 423368003391 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 423368003392 RecT family; Region: RecT; pfam03837 423368003393 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 423368003394 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 423368003395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368003396 non-specific DNA binding site [nucleotide binding]; other site 423368003397 salt bridge; other site 423368003398 sequence-specific DNA binding site [nucleotide binding]; other site 423368003399 Bacteriophage CII protein; Region: Phage_CII; pfam05269 423368003400 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 423368003401 primosomal protein DnaI; Provisional; Region: PRK02854 423368003402 putative replication protein; Provisional; Region: PRK12377 423368003403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368003404 Walker A motif; other site 423368003405 ATP binding site [chemical binding]; other site 423368003406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 423368003407 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 423368003408 DinI-like family; Region: DinI; pfam06183 423368003409 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 423368003410 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 423368003411 Antitermination protein; Region: Antiterm; pfam03589 423368003412 Antitermination protein; Region: Antiterm; pfam03589 423368003413 PipA protein; Region: PipA; pfam07108 423368003414 phage holin, lambda family; Region: holin_lambda; TIGR01594 423368003415 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 423368003416 catalytic residues [active] 423368003417 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 423368003418 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 423368003419 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 423368003420 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 423368003421 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 423368003422 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 423368003423 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 423368003424 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 423368003425 oligomer interface [polypeptide binding]; other site 423368003426 active site residues [active] 423368003427 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 423368003428 Uncharacterized conserved protein [Function unknown]; Region: COG5471 423368003429 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 423368003430 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 423368003431 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 423368003432 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 423368003433 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 423368003434 Minor tail protein T; Region: Phage_tail_T; cl05636 423368003435 Phage-related minor tail protein [Function unknown]; Region: COG5281 423368003436 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 423368003437 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 423368003438 Phage-related protein [Function unknown]; Region: COG4718 423368003439 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 423368003440 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 423368003441 E-class dimer interface [polypeptide binding]; other site 423368003442 P-class dimer interface [polypeptide binding]; other site 423368003443 active site 423368003444 Cu2+ binding site [ion binding]; other site 423368003445 Zn2+ binding site [ion binding]; other site 423368003446 Phage-related protein [Function unknown]; Region: gp18; COG4672 423368003447 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 423368003448 MPN+ (JAMM) motif; other site 423368003449 Zinc-binding site [ion binding]; other site 423368003450 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 423368003451 NlpC/P60 family; Region: NLPC_P60; cl17555 423368003452 Phage-related protein, tail component [Function unknown]; Region: COG4723 423368003453 Phage-related protein, tail component [Function unknown]; Region: COG4733 423368003454 Putative phage tail protein; Region: Phage-tail_3; pfam13550 423368003455 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 423368003456 Interdomain contacts; other site 423368003457 Cytokine receptor motif; other site 423368003458 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 423368003459 Fibronectin type III protein; Region: DUF3672; pfam12421 423368003460 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 423368003461 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368003462 Phage Tail Collar Domain; Region: Collar; pfam07484 423368003463 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368003464 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 423368003465 hypothetical protein; Provisional; Region: PRK09951 423368003466 DinI-like family; Region: DinI; cl11630 423368003467 aminopeptidase N; Provisional; Region: pepN; PRK14015 423368003468 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 423368003469 active site 423368003470 Zn binding site [ion binding]; other site 423368003471 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 423368003472 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 423368003473 quinone interaction residues [chemical binding]; other site 423368003474 active site 423368003475 catalytic residues [active] 423368003476 FMN binding site [chemical binding]; other site 423368003477 substrate binding site [chemical binding]; other site 423368003478 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 423368003479 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 423368003480 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 423368003481 MOSC domain; Region: MOSC; pfam03473 423368003482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 423368003483 catalytic loop [active] 423368003484 iron binding site [ion binding]; other site 423368003485 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 423368003486 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 423368003487 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 423368003488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368003489 S-adenosylmethionine binding site [chemical binding]; other site 423368003490 ABC transporter ATPase component; Reviewed; Region: PRK11147 423368003491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003493 Walker A/P-loop; other site 423368003494 Walker A/P-loop; other site 423368003495 ATP binding site [chemical binding]; other site 423368003496 ATP binding site [chemical binding]; other site 423368003497 Q-loop/lid; other site 423368003498 Q-loop/lid; other site 423368003499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368003500 ABC transporter signature motif; other site 423368003501 Walker B; other site 423368003502 D-loop; other site 423368003503 ABC transporter; Region: ABC_tran_2; pfam12848 423368003504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368003505 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 423368003506 Paraquat-inducible protein A; Region: PqiA; pfam04403 423368003507 Paraquat-inducible protein A; Region: PqiA; pfam04403 423368003508 paraquat-inducible protein B; Provisional; Region: PRK10807 423368003509 mce related protein; Region: MCE; pfam02470 423368003510 mce related protein; Region: MCE; pfam02470 423368003511 mce related protein; Region: MCE; pfam02470 423368003512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 423368003513 Protein of unknown function (DUF330); Region: DUF330; pfam03886 423368003514 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 423368003515 active site 1 [active] 423368003516 dimer interface [polypeptide binding]; other site 423368003517 active site 2 [active] 423368003518 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 423368003519 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 423368003520 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 423368003521 outer membrane protein A; Reviewed; Region: PRK10808 423368003522 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 423368003523 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 423368003524 ligand binding site [chemical binding]; other site 423368003525 cell division inhibitor SulA; Region: sula; TIGR00623 423368003526 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 423368003527 TfoX C-terminal domain; Region: TfoX_C; pfam04994 423368003528 TIGR01666 family membrane protein; Region: YCCS 423368003529 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 423368003530 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 423368003531 Predicted membrane protein [Function unknown]; Region: COG3304 423368003532 Domain of unknown function (DUF307); Region: DUF307; pfam03733 423368003533 Domain of unknown function (DUF307); Region: DUF307; pfam03733 423368003534 DNA helicase IV; Provisional; Region: helD; PRK11054 423368003535 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 423368003536 Part of AAA domain; Region: AAA_19; pfam13245 423368003537 Family description; Region: UvrD_C_2; pfam13538 423368003538 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 423368003539 active site 423368003540 dimer interfaces [polypeptide binding]; other site 423368003541 catalytic residues [active] 423368003542 hypothetical protein; Provisional; Region: PRK03641 423368003543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 423368003544 heat shock protein HspQ; Provisional; Region: PRK14129 423368003545 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 423368003546 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 423368003547 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 423368003548 putative RNA binding site [nucleotide binding]; other site 423368003549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368003550 S-adenosylmethionine binding site [chemical binding]; other site 423368003551 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 423368003552 substrate binding site [chemical binding]; other site 423368003553 Cupin domain; Region: Cupin_2; cl17218 423368003554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368003555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368003556 acylphosphatase; Provisional; Region: PRK14426 423368003557 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 423368003558 sulfur transfer protein TusE; Provisional; Region: PRK11508 423368003559 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 423368003560 YccA-like proteins; Region: YccA_like; cd10433 423368003561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368003562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368003563 active site 423368003564 DNA binding site [nucleotide binding] 423368003565 Int/Topo IB signature motif; other site 423368003566 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 423368003567 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 423368003568 exonuclease VIII; Reviewed; Region: PRK09709 423368003569 exonuclease VIII; Reviewed; Region: PRK09709 423368003570 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 423368003571 Helix-turn-helix domain; Region: HTH_36; pfam13730 423368003572 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 423368003573 replicative DNA helicase; Region: DnaB; TIGR00665 423368003574 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 423368003575 Walker A motif; other site 423368003576 ATP binding site [chemical binding]; other site 423368003577 Walker B motif; other site 423368003578 DNA binding loops [nucleotide binding] 423368003579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 423368003580 MT-A70; Region: MT-A70; cl01947 423368003581 Methyltransferase domain; Region: Methyltransf_23; pfam13489 423368003582 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 423368003583 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 423368003584 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 423368003585 catalytic residues [active] 423368003586 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 423368003587 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 423368003588 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 423368003589 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 423368003590 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 423368003591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 423368003592 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 423368003593 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 423368003594 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 423368003595 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 423368003596 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 423368003597 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 423368003598 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368003599 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368003600 catalytic residue [active] 423368003601 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 423368003602 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 423368003603 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 423368003604 Baseplate J-like protein; Region: Baseplate_J; cl01294 423368003605 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 423368003606 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 423368003607 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368003608 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368003609 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 423368003610 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 423368003611 PipA protein; Region: PipA; pfam07108 423368003612 secreted effector protein PipB; Provisional; Region: PRK15197 423368003613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368003614 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368003615 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368003616 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 423368003617 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 423368003618 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 423368003619 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 423368003620 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 423368003621 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 423368003622 HAMP domain; Region: HAMP; pfam00672 423368003623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368003624 dimer interface [polypeptide binding]; other site 423368003625 phosphorylation site [posttranslational modification] 423368003626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368003627 ATP binding site [chemical binding]; other site 423368003628 Mg2+ binding site [ion binding]; other site 423368003629 G-X-G motif; other site 423368003630 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 423368003631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368003632 active site 423368003633 phosphorylation site [posttranslational modification] 423368003634 intermolecular recognition site; other site 423368003635 dimerization interface [polypeptide binding]; other site 423368003636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368003637 DNA binding site [nucleotide binding] 423368003638 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 423368003639 active site 423368003640 homotetramer interface [polypeptide binding]; other site 423368003641 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 423368003642 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 423368003643 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 423368003644 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 423368003645 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 423368003646 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 423368003647 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 423368003648 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 423368003649 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 423368003650 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 423368003651 NAD binding site [chemical binding]; other site 423368003652 catalytic residues [active] 423368003653 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 423368003654 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 423368003655 putative active site [active] 423368003656 putative metal binding site [ion binding]; other site 423368003657 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 423368003658 putative substrate binding pocket [chemical binding]; other site 423368003659 trimer interface [polypeptide binding]; other site 423368003660 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 423368003661 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 423368003662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003663 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 423368003664 putative substrate translocation pore; other site 423368003665 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 423368003666 Cupin domain; Region: Cupin_2; pfam07883 423368003667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368003668 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 423368003669 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 423368003670 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 423368003671 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 423368003672 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 423368003673 HSP70 interaction site [polypeptide binding]; other site 423368003674 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 423368003675 substrate binding site [polypeptide binding]; other site 423368003676 dimer interface [polypeptide binding]; other site 423368003677 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 423368003678 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 423368003679 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 423368003680 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 423368003681 DsbD alpha interface [polypeptide binding]; other site 423368003682 catalytic residues [active] 423368003683 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 423368003684 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 423368003685 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 423368003686 catalytic residues [active] 423368003687 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 423368003688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 423368003689 catalytic residues [active] 423368003690 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 423368003691 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 423368003692 catalytic core [active] 423368003693 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 423368003694 hypothetical protein; Provisional; Region: PRK10174 423368003695 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 423368003696 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 423368003697 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 423368003698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368003699 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 423368003700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 423368003701 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 423368003702 Predicted transcriptional regulator [Transcription]; Region: COG3905 423368003703 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 423368003704 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 423368003705 Glutamate binding site [chemical binding]; other site 423368003706 NAD binding site [chemical binding]; other site 423368003707 catalytic residues [active] 423368003708 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 423368003709 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 423368003710 Na binding site [ion binding]; other site 423368003711 hypothetical protein; Provisional; Region: PRK10536 423368003712 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 423368003713 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 423368003714 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 423368003715 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 423368003716 putative active site [active] 423368003717 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 423368003718 Na binding site [ion binding]; other site 423368003719 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 423368003720 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 423368003721 putative active site cavity [active] 423368003722 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 423368003723 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 423368003724 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 423368003725 putative sialic acid transporter; Provisional; Region: PRK12307 423368003726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003727 putative substrate translocation pore; other site 423368003728 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 423368003729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 423368003730 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 423368003731 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 423368003732 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 423368003733 putative ligand binding site [chemical binding]; other site 423368003734 NAD binding site [chemical binding]; other site 423368003735 dimerization interface [polypeptide binding]; other site 423368003736 catalytic site [active] 423368003737 putative hydrolase; Validated; Region: PRK09248 423368003738 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 423368003739 active site 423368003740 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 423368003741 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 423368003742 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 423368003743 curli assembly protein CsgF; Provisional; Region: PRK10050 423368003744 curli assembly protein CsgE; Provisional; Region: PRK10386 423368003745 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 423368003746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368003747 DNA binding residues [nucleotide binding] 423368003748 dimerization interface [polypeptide binding]; other site 423368003749 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 423368003750 Curlin associated repeat; Region: Curlin_rpt; pfam07012 423368003751 Curlin associated repeat; Region: Curlin_rpt; pfam07012 423368003752 major curlin subunit; Provisional; Region: csgA; PRK10051 423368003753 Curlin associated repeat; Region: Curlin_rpt; pfam07012 423368003754 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 423368003755 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 423368003756 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 423368003757 putative ADP-ribose binding site [chemical binding]; other site 423368003758 putative active site [active] 423368003759 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 423368003760 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 423368003761 putative active site [active] 423368003762 catalytic site [active] 423368003763 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 423368003764 putative active site [active] 423368003765 catalytic site [active] 423368003766 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 423368003767 Acyltransferase family; Region: Acyl_transf_3; pfam01757 423368003768 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 423368003769 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 423368003770 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 423368003771 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 423368003772 Ligand binding site; other site 423368003773 DXD motif; other site 423368003774 lipoprotein; Provisional; Region: PRK10175 423368003775 secY/secA suppressor protein; Provisional; Region: PRK11467 423368003776 drug efflux system protein MdtG; Provisional; Region: PRK09874 423368003777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003778 putative substrate translocation pore; other site 423368003779 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 423368003780 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 423368003781 putative acyl-acceptor binding pocket; other site 423368003782 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 423368003783 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 423368003784 active site residue [active] 423368003785 hypothetical protein; Provisional; Region: PRK03757 423368003786 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 423368003787 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 423368003788 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 423368003789 hydroxyglutarate oxidase; Provisional; Region: PRK11728 423368003790 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 423368003791 DNA damage-inducible protein I; Provisional; Region: PRK10597 423368003792 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 423368003793 active site 423368003794 substrate binding pocket [chemical binding]; other site 423368003795 dimer interface [polypeptide binding]; other site 423368003796 lipoprotein; Provisional; Region: PRK10598 423368003797 glutaredoxin 2; Provisional; Region: PRK10387 423368003798 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 423368003799 C-terminal domain interface [polypeptide binding]; other site 423368003800 GSH binding site (G-site) [chemical binding]; other site 423368003801 catalytic residues [active] 423368003802 putative dimer interface [polypeptide binding]; other site 423368003803 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 423368003804 N-terminal domain interface [polypeptide binding]; other site 423368003805 multidrug resistance protein MdtH; Provisional; Region: PRK11646 423368003806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368003807 putative substrate translocation pore; other site 423368003808 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 423368003809 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 423368003810 hypothetical protein; Provisional; Region: PRK11239 423368003811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 423368003812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 423368003813 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 423368003814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 423368003815 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 423368003816 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 423368003817 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 423368003818 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 423368003819 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 423368003820 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 423368003821 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 423368003822 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 423368003823 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 423368003824 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 423368003825 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 423368003826 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 423368003827 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 423368003828 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 423368003829 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 423368003830 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 423368003831 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 423368003832 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 423368003833 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 423368003834 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 423368003835 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 423368003836 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 423368003837 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 423368003838 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 423368003839 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 423368003840 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 423368003841 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 423368003842 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 423368003843 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 423368003844 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 423368003845 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 423368003846 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 423368003847 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 423368003848 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 423368003849 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 423368003850 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 423368003851 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 423368003852 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 423368003853 homodimer interface [polypeptide binding]; other site 423368003854 oligonucleotide binding site [chemical binding]; other site 423368003855 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 423368003856 RNase E 5' UTR element 423368003857 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 423368003858 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368003859 RNA binding surface [nucleotide binding]; other site 423368003860 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 423368003861 active site 423368003862 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 423368003863 Maf-like protein; Region: Maf; pfam02545 423368003864 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 423368003865 active site 423368003866 dimer interface [polypeptide binding]; other site 423368003867 hypothetical protein; Provisional; Region: PRK11193 423368003868 putative phosphate acyltransferase; Provisional; Region: PRK05331 423368003869 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 423368003870 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 423368003871 dimer interface [polypeptide binding]; other site 423368003872 active site 423368003873 CoA binding pocket [chemical binding]; other site 423368003874 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 423368003875 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 423368003876 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 423368003877 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 423368003878 NAD(P) binding site [chemical binding]; other site 423368003879 homotetramer interface [polypeptide binding]; other site 423368003880 homodimer interface [polypeptide binding]; other site 423368003881 active site 423368003882 acyl carrier protein; Provisional; Region: acpP; PRK00982 423368003883 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 423368003884 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 423368003885 dimer interface [polypeptide binding]; other site 423368003886 active site 423368003887 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 423368003888 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 423368003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368003890 catalytic residue [active] 423368003891 conserved hypothetical protein, YceG family; Region: TIGR00247 423368003892 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 423368003893 dimerization interface [polypeptide binding]; other site 423368003894 thymidylate kinase; Validated; Region: tmk; PRK00698 423368003895 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 423368003896 TMP-binding site; other site 423368003897 ATP-binding site [chemical binding]; other site 423368003898 DNA polymerase III subunit delta'; Validated; Region: PRK07993 423368003899 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 423368003900 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 423368003901 active site 423368003902 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 423368003903 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 423368003904 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 423368003905 active site turn [active] 423368003906 phosphorylation site [posttranslational modification] 423368003907 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 423368003908 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368003909 N-terminal plug; other site 423368003910 ligand-binding site [chemical binding]; other site 423368003911 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 423368003912 nucleotide binding site/active site [active] 423368003913 HIT family signature motif; other site 423368003914 catalytic residue [active] 423368003915 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 423368003916 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 423368003917 putative dimer interface [polypeptide binding]; other site 423368003918 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 423368003919 thiamine kinase; Region: ycfN_thiK; TIGR02721 423368003920 thiamine kinase; Provisional; Region: thiK; PRK10271 423368003921 substrate binding site [chemical binding]; other site 423368003922 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 423368003923 beta-hexosaminidase; Provisional; Region: PRK05337 423368003924 hypothetical protein; Provisional; Region: PRK04940 423368003925 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 423368003926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368003927 hypothetical protein; Provisional; Region: PRK11280 423368003928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 423368003929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368003930 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368003931 L,D-transpeptidase; Provisional; Region: PRK10190 423368003932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368003933 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368003934 transcription-repair coupling factor; Provisional; Region: PRK10689 423368003935 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 423368003936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368003937 ATP binding site [chemical binding]; other site 423368003938 putative Mg++ binding site [ion binding]; other site 423368003939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368003940 nucleotide binding region [chemical binding]; other site 423368003941 ATP-binding site [chemical binding]; other site 423368003942 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 423368003943 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 423368003944 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 423368003945 FtsX-like permease family; Region: FtsX; pfam02687 423368003946 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 423368003947 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 423368003948 Walker A/P-loop; other site 423368003949 ATP binding site [chemical binding]; other site 423368003950 Q-loop/lid; other site 423368003951 ABC transporter signature motif; other site 423368003952 Walker B; other site 423368003953 D-loop; other site 423368003954 H-loop/switch region; other site 423368003955 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 423368003956 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 423368003957 FtsX-like permease family; Region: FtsX; pfam02687 423368003958 fructokinase; Reviewed; Region: PRK09557 423368003959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368003960 nucleotide binding site [chemical binding]; other site 423368003961 NAD-dependent deacetylase; Provisional; Region: PRK00481 423368003962 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 423368003963 NAD+ binding site [chemical binding]; other site 423368003964 substrate binding site [chemical binding]; other site 423368003965 Zn binding site [ion binding]; other site 423368003966 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 423368003967 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 423368003968 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 423368003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368003970 dimer interface [polypeptide binding]; other site 423368003971 conserved gate region; other site 423368003972 putative PBP binding loops; other site 423368003973 ABC-ATPase subunit interface; other site 423368003974 Sif protein; Region: Sif; pfam06767 423368003975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 423368003976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368003977 dimer interface [polypeptide binding]; other site 423368003978 conserved gate region; other site 423368003979 putative PBP binding loops; other site 423368003980 ABC-ATPase subunit interface; other site 423368003981 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 423368003982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368003983 Walker A/P-loop; other site 423368003984 ATP binding site [chemical binding]; other site 423368003985 Q-loop/lid; other site 423368003986 ABC transporter signature motif; other site 423368003987 Walker B; other site 423368003988 D-loop; other site 423368003989 H-loop/switch region; other site 423368003990 TOBE domain; Region: TOBE_2; pfam08402 423368003991 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 423368003992 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 423368003993 metal binding site [ion binding]; metal-binding site 423368003994 dimer interface [polypeptide binding]; other site 423368003995 Uncharacterized conserved protein [Function unknown]; Region: COG2850 423368003996 Cupin domain; Region: Cupin_2; cl17218 423368003997 sensor protein PhoQ; Provisional; Region: PRK10815 423368003998 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 423368003999 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 423368004000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368004001 ATP binding site [chemical binding]; other site 423368004002 Mg2+ binding site [ion binding]; other site 423368004003 G-X-G motif; other site 423368004004 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 423368004005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368004006 active site 423368004007 phosphorylation site [posttranslational modification] 423368004008 intermolecular recognition site; other site 423368004009 dimerization interface [polypeptide binding]; other site 423368004010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368004011 DNA binding site [nucleotide binding] 423368004012 adenylosuccinate lyase; Provisional; Region: PRK09285 423368004013 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 423368004014 tetramer interface [polypeptide binding]; other site 423368004015 active site 423368004016 putative lysogenization regulator; Reviewed; Region: PRK00218 423368004017 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 423368004018 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 423368004019 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 423368004020 nudix motif; other site 423368004021 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 423368004022 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 423368004023 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 423368004024 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 423368004025 probable active site [active] 423368004026 isocitrate dehydrogenase; Validated; Region: PRK07362 423368004027 isocitrate dehydrogenase; Reviewed; Region: PRK07006 423368004028 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 423368004029 Ricin-type beta-trefoil; Region: RICIN; smart00458 423368004030 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 423368004031 putative sugar binding sites [chemical binding]; other site 423368004032 Q-X-W motif; other site 423368004033 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 423368004034 lysozyme inhibitor; Provisional; Region: PRK13791 423368004035 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 423368004036 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 423368004037 putative dimer interface [polypeptide binding]; other site 423368004038 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 423368004039 BNR repeat-like domain; Region: BNR_2; pfam13088 423368004040 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 423368004041 TRL-like protein family; Region: TRL; pfam13146 423368004042 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 423368004043 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 423368004044 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 423368004045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368004046 dimer interface [polypeptide binding]; other site 423368004047 conserved gate region; other site 423368004048 ABC-ATPase subunit interface; other site 423368004049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 423368004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368004051 dimer interface [polypeptide binding]; other site 423368004052 conserved gate region; other site 423368004053 putative PBP binding loops; other site 423368004054 ABC-ATPase subunit interface; other site 423368004055 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368004056 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 423368004057 Walker A/P-loop; other site 423368004058 ATP binding site [chemical binding]; other site 423368004059 Q-loop/lid; other site 423368004060 ABC transporter signature motif; other site 423368004061 Walker B; other site 423368004062 D-loop; other site 423368004063 H-loop/switch region; other site 423368004064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368004065 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 423368004066 Walker A/P-loop; other site 423368004067 ATP binding site [chemical binding]; other site 423368004068 Q-loop/lid; other site 423368004069 ABC transporter signature motif; other site 423368004070 Walker B; other site 423368004071 D-loop; other site 423368004072 H-loop/switch region; other site 423368004073 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 423368004074 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368004075 zinc/cadmium-binding protein; Provisional; Region: PRK10306 423368004076 aminoglycoside resistance protein; Provisional; Region: PRK13746 423368004077 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 423368004078 active site 423368004079 NTP binding site [chemical binding]; other site 423368004080 metal binding triad [ion binding]; metal-binding site 423368004081 antibiotic binding site [chemical binding]; other site 423368004082 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 423368004083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368004084 DNA binding residues [nucleotide binding] 423368004085 transcriptional regulator MirA; Provisional; Region: PRK15043 423368004086 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 423368004087 DNA binding residues [nucleotide binding] 423368004088 dimer interface [polypeptide binding]; other site 423368004089 Pleckstrin homology-like domain; Region: PH-like; cl17171 423368004090 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 423368004091 chorismate mutase; Provisional; Region: PRK08055 423368004092 leucine export protein LeuE; Provisional; Region: PRK10958 423368004093 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 423368004094 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 423368004095 hypothetical protein; Provisional; Region: PRK10457 423368004096 hypothetical protein; Provisional; Region: PRK14760 423368004097 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 423368004098 murein hydrolase B; Provisional; Region: PRK10760; cl17906 423368004099 Domain of unknown function (DUF333); Region: DUF333; pfam03891 423368004100 Uncharacterized conserved protein [Function unknown]; Region: COG3189 423368004101 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 423368004102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004103 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368004104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368004105 Predicted membrane protein [Function unknown]; Region: COG2707 423368004106 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 423368004107 putative deacylase active site [active] 423368004108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 423368004109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368004110 metal binding site [ion binding]; metal-binding site 423368004111 active site 423368004112 I-site; other site 423368004113 hypothetical protein; Provisional; Region: PRK05325 423368004114 PrkA family serine protein kinase; Provisional; Region: PRK15455 423368004115 AAA ATPase domain; Region: AAA_16; pfam13191 423368004116 Walker A motif; other site 423368004117 ATP binding site [chemical binding]; other site 423368004118 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 423368004119 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 423368004120 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 423368004121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368004122 FeS/SAM binding site; other site 423368004123 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 423368004124 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368004125 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368004126 active site 423368004127 catalytic tetrad [active] 423368004128 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 423368004129 active site 423368004130 phosphate binding residues; other site 423368004131 catalytic residues [active] 423368004132 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 423368004133 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 423368004134 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 423368004135 methionine sulfoxide reductase B; Provisional; Region: PRK00222 423368004136 SelR domain; Region: SelR; pfam01641 423368004137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 423368004138 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 423368004139 Isochorismatase family; Region: Isochorismatase; pfam00857 423368004140 catalytic triad [active] 423368004141 metal binding site [ion binding]; metal-binding site 423368004142 conserved cis-peptide bond; other site 423368004143 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 423368004144 active site 423368004145 homodimer interface [polypeptide binding]; other site 423368004146 protease 4; Provisional; Region: PRK10949 423368004147 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 423368004148 tandem repeat interface [polypeptide binding]; other site 423368004149 oligomer interface [polypeptide binding]; other site 423368004150 active site residues [active] 423368004151 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 423368004152 tandem repeat interface [polypeptide binding]; other site 423368004153 oligomer interface [polypeptide binding]; other site 423368004154 active site residues [active] 423368004155 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 423368004156 putative FMN binding site [chemical binding]; other site 423368004157 selenophosphate synthetase; Provisional; Region: PRK00943 423368004158 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 423368004159 dimerization interface [polypeptide binding]; other site 423368004160 putative ATP binding site [chemical binding]; other site 423368004161 DNA topoisomerase III; Provisional; Region: PRK07726 423368004162 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 423368004163 active site 423368004164 putative interdomain interaction site [polypeptide binding]; other site 423368004165 putative metal-binding site [ion binding]; other site 423368004166 putative nucleotide binding site [chemical binding]; other site 423368004167 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 423368004168 domain I; other site 423368004169 DNA binding groove [nucleotide binding] 423368004170 phosphate binding site [ion binding]; other site 423368004171 domain II; other site 423368004172 domain III; other site 423368004173 nucleotide binding site [chemical binding]; other site 423368004174 catalytic site [active] 423368004175 domain IV; other site 423368004176 glutamate dehydrogenase; Provisional; Region: PRK09414 423368004177 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 423368004178 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 423368004179 NAD(P) binding site [chemical binding]; other site 423368004180 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 423368004181 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 423368004182 active site 423368004183 8-oxo-dGMP binding site [chemical binding]; other site 423368004184 nudix motif; other site 423368004185 metal binding site [ion binding]; metal-binding site 423368004186 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 423368004187 putative catalytic site [active] 423368004188 putative phosphate binding site [ion binding]; other site 423368004189 active site 423368004190 metal binding site A [ion binding]; metal-binding site 423368004191 DNA binding site [nucleotide binding] 423368004192 putative AP binding site [nucleotide binding]; other site 423368004193 putative metal binding site B [ion binding]; other site 423368004194 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 423368004195 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 423368004196 inhibitor-cofactor binding pocket; inhibition site 423368004197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368004198 catalytic residue [active] 423368004199 arginine succinyltransferase; Provisional; Region: PRK10456 423368004200 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 423368004201 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 423368004202 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 423368004203 NAD(P) binding site [chemical binding]; other site 423368004204 catalytic residues [active] 423368004205 succinylarginine dihydrolase; Provisional; Region: PRK13281 423368004206 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 423368004207 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 423368004208 putative active site [active] 423368004209 Zn binding site [ion binding]; other site 423368004210 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 423368004211 dimer interface [polypeptide binding]; other site 423368004212 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 423368004213 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 423368004214 GIY-YIG motif/motif A; other site 423368004215 active site 423368004216 catalytic site [active] 423368004217 putative DNA binding site [nucleotide binding]; other site 423368004218 metal binding site [ion binding]; metal-binding site 423368004219 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 423368004220 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 423368004221 homodimer interface [polypeptide binding]; other site 423368004222 NAD binding pocket [chemical binding]; other site 423368004223 ATP binding pocket [chemical binding]; other site 423368004224 Mg binding site [ion binding]; other site 423368004225 active-site loop [active] 423368004226 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 423368004227 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 423368004228 active site 423368004229 P-loop; other site 423368004230 phosphorylation site [posttranslational modification] 423368004231 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 423368004232 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 423368004233 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 423368004234 methionine cluster; other site 423368004235 active site 423368004236 phosphorylation site [posttranslational modification] 423368004237 metal binding site [ion binding]; metal-binding site 423368004238 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 423368004239 Cupin domain; Region: Cupin_2; pfam07883 423368004240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368004241 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 423368004242 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 423368004243 NAD binding site [chemical binding]; other site 423368004244 sugar binding site [chemical binding]; other site 423368004245 divalent metal binding site [ion binding]; other site 423368004246 tetramer (dimer of dimers) interface [polypeptide binding]; other site 423368004247 dimer interface [polypeptide binding]; other site 423368004248 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 423368004249 putative active site [active] 423368004250 YdjC motif; other site 423368004251 Mg binding site [ion binding]; other site 423368004252 putative homodimer interface [polypeptide binding]; other site 423368004253 hydroperoxidase II; Provisional; Region: katE; PRK11249 423368004254 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 423368004255 tetramer interface [polypeptide binding]; other site 423368004256 heme binding pocket [chemical binding]; other site 423368004257 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 423368004258 domain interactions; other site 423368004259 cell division modulator; Provisional; Region: PRK10113 423368004260 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 423368004261 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 423368004262 inner membrane protein; Provisional; Region: PRK11648 423368004263 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 423368004264 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 423368004265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368004266 motif II; other site 423368004267 YniB-like protein; Region: YniB; pfam14002 423368004268 Phosphotransferase enzyme family; Region: APH; pfam01636 423368004269 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 423368004270 active site 423368004271 ATP binding site [chemical binding]; other site 423368004272 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 423368004273 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 423368004274 6-phosphofructokinase 2; Provisional; Region: PRK10294 423368004275 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 423368004276 putative substrate binding site [chemical binding]; other site 423368004277 putative ATP binding site [chemical binding]; other site 423368004278 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 423368004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 423368004280 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 423368004281 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 423368004282 active site 423368004283 substrate binding site [chemical binding]; other site 423368004284 Mg2+ binding site [ion binding]; other site 423368004285 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 423368004286 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 423368004287 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 423368004288 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 423368004289 active site 423368004290 dimer interface [polypeptide binding]; other site 423368004291 motif 1; other site 423368004292 motif 2; other site 423368004293 motif 3; other site 423368004294 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 423368004295 anticodon binding site; other site 423368004296 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 423368004297 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 423368004298 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 423368004299 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 423368004300 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 423368004301 23S rRNA binding site [nucleotide binding]; other site 423368004302 L21 binding site [polypeptide binding]; other site 423368004303 L13 binding site [polypeptide binding]; other site 423368004304 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 423368004305 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 423368004306 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 423368004307 dimer interface [polypeptide binding]; other site 423368004308 motif 1; other site 423368004309 active site 423368004310 motif 2; other site 423368004311 motif 3; other site 423368004312 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 423368004313 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 423368004314 putative tRNA-binding site [nucleotide binding]; other site 423368004315 B3/4 domain; Region: B3_4; pfam03483 423368004316 tRNA synthetase B5 domain; Region: B5; smart00874 423368004317 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 423368004318 dimer interface [polypeptide binding]; other site 423368004319 motif 1; other site 423368004320 motif 3; other site 423368004321 motif 2; other site 423368004322 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 423368004323 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 423368004324 IHF dimer interface [polypeptide binding]; other site 423368004325 IHF - DNA interface [nucleotide binding]; other site 423368004326 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 423368004327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368004328 ABC-ATPase subunit interface; other site 423368004329 dimer interface [polypeptide binding]; other site 423368004330 putative PBP binding regions; other site 423368004331 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 423368004332 catalytic residues [active] 423368004333 dimer interface [polypeptide binding]; other site 423368004334 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 423368004335 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 423368004336 Walker A/P-loop; other site 423368004337 ATP binding site [chemical binding]; other site 423368004338 Q-loop/lid; other site 423368004339 ABC transporter signature motif; other site 423368004340 Walker B; other site 423368004341 D-loop; other site 423368004342 H-loop/switch region; other site 423368004343 NlpC/P60 family; Region: NLPC_P60; pfam00877 423368004344 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 423368004345 Uncharacterized conserved protein [Function unknown]; Region: COG0397 423368004346 hypothetical protein; Validated; Region: PRK00029 423368004347 hypothetical protein; Provisional; Region: PRK10183 423368004348 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 423368004349 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 423368004350 PEP synthetase regulatory protein; Provisional; Region: PRK05339 423368004351 phosphoenolpyruvate synthase; Validated; Region: PRK06464 423368004352 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 423368004353 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 423368004354 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 423368004355 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 423368004356 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 423368004357 acyl-activating enzyme (AAE) consensus motif; other site 423368004358 putative AMP binding site [chemical binding]; other site 423368004359 putative active site [active] 423368004360 putative CoA binding site [chemical binding]; other site 423368004361 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 423368004362 oxidoreductase; Provisional; Region: PRK10015 423368004363 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 423368004364 Electron transfer flavoprotein domain; Region: ETF; smart00893 423368004365 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 423368004366 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 423368004367 Ligand binding site [chemical binding]; other site 423368004368 Electron transfer flavoprotein domain; Region: ETF; pfam01012 423368004369 Cupin domain; Region: Cupin_2; pfam07883 423368004370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368004371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368004372 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 423368004373 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 423368004374 active site 423368004375 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 423368004376 Coenzyme A transferase; Region: CoA_trans; smart00882 423368004377 Coenzyme A transferase; Region: CoA_trans; cl17247 423368004378 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 423368004379 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 423368004380 active site 423368004381 catalytic residue [active] 423368004382 dimer interface [polypeptide binding]; other site 423368004383 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 423368004384 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 423368004385 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 423368004386 shikimate binding site; other site 423368004387 NAD(P) binding site [chemical binding]; other site 423368004388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368004390 putative substrate translocation pore; other site 423368004391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368004393 putative substrate translocation pore; other site 423368004394 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 423368004395 putative inner membrane protein; Provisional; Region: PRK10983 423368004396 Domain of unknown function DUF20; Region: UPF0118; pfam01594 423368004397 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 423368004398 FAD binding domain; Region: FAD_binding_4; pfam01565 423368004399 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 423368004400 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 423368004401 CoenzymeA binding site [chemical binding]; other site 423368004402 subunit interaction site [polypeptide binding]; other site 423368004403 PHB binding site; other site 423368004404 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 423368004405 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 423368004406 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 423368004407 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 423368004408 putative ABC transporter; Region: ycf24; CHL00085 423368004409 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 423368004410 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 423368004411 Walker A/P-loop; other site 423368004412 ATP binding site [chemical binding]; other site 423368004413 Q-loop/lid; other site 423368004414 ABC transporter signature motif; other site 423368004415 Walker B; other site 423368004416 D-loop; other site 423368004417 H-loop/switch region; other site 423368004418 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 423368004419 FeS assembly protein SufD; Region: sufD; TIGR01981 423368004420 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 423368004421 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 423368004422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368004423 catalytic residue [active] 423368004424 cysteine desufuration protein SufE; Provisional; Region: PRK09296 423368004425 L,D-transpeptidase; Provisional; Region: PRK10190 423368004426 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368004427 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368004428 murein lipoprotein; Provisional; Region: PRK15396 423368004429 murein lipoprotein; Provisional; Region: PRK15396 423368004430 pyruvate kinase; Provisional; Region: PRK09206 423368004431 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 423368004432 domain interfaces; other site 423368004433 active site 423368004434 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 423368004435 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 423368004436 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 423368004437 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368004438 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368004439 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368004440 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 423368004441 substrate binding site [chemical binding]; other site 423368004442 dimer interface [polypeptide binding]; other site 423368004443 ATP binding site [chemical binding]; other site 423368004444 tetrathionate reductase subunit A; Provisional; Region: PRK14991 423368004445 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 423368004446 putative [Fe4-S4] binding site [ion binding]; other site 423368004447 putative molybdopterin cofactor binding site [chemical binding]; other site 423368004448 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 423368004449 putative molybdopterin cofactor binding site; other site 423368004450 tetrathionate reductase subunit C; Provisional; Region: PRK14992 423368004451 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 423368004452 tetrathionate reductase subunit B; Provisional; Region: PRK14993 423368004453 4Fe-4S binding domain; Region: Fer4; pfam00037 423368004454 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 423368004455 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 423368004456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 423368004457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368004458 dimer interface [polypeptide binding]; other site 423368004459 phosphorylation site [posttranslational modification] 423368004460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368004461 ATP binding site [chemical binding]; other site 423368004462 Mg2+ binding site [ion binding]; other site 423368004463 G-X-G motif; other site 423368004464 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 423368004465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368004466 active site 423368004467 phosphorylation site [posttranslational modification] 423368004468 intermolecular recognition site; other site 423368004469 dimerization interface [polypeptide binding]; other site 423368004470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368004471 DNA binding residues [nucleotide binding] 423368004472 dimerization interface [polypeptide binding]; other site 423368004473 hypothetical protein; Provisional; Region: PRK10292 423368004474 Uncharacterized conserved protein [Function unknown]; Region: COG1683 423368004475 Uncharacterized conserved protein [Function unknown]; Region: COG3272 423368004476 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 423368004477 transcriptional regulator MirA; Provisional; Region: PRK15043 423368004478 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 423368004479 DNA binding residues [nucleotide binding] 423368004480 two component system sensor kinase SsrB; Provisional; Region: PRK15369 423368004481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368004482 active site 423368004483 phosphorylation site [posttranslational modification] 423368004484 intermolecular recognition site; other site 423368004485 dimerization interface [polypeptide binding]; other site 423368004486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368004487 DNA binding residues [nucleotide binding] 423368004488 dimerization interface [polypeptide binding]; other site 423368004489 two component system sensor kinase SsrA; Provisional; Region: PRK15347 423368004490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368004491 dimerization interface [polypeptide binding]; other site 423368004492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368004493 dimer interface [polypeptide binding]; other site 423368004494 phosphorylation site [posttranslational modification] 423368004495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368004496 ATP binding site [chemical binding]; other site 423368004497 Mg2+ binding site [ion binding]; other site 423368004498 G-X-G motif; other site 423368004499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368004500 active site 423368004501 phosphorylation site [posttranslational modification] 423368004502 intermolecular recognition site; other site 423368004503 dimerization interface [polypeptide binding]; other site 423368004504 outer membrane secretin SsaC; Provisional; Region: PRK15346 423368004505 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 423368004506 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 423368004507 type III secretion system protein SsaD; Provisional; Region: PRK15367 423368004508 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 423368004509 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 423368004510 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 423368004511 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 423368004512 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 423368004513 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 423368004514 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 423368004515 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 423368004516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 423368004517 TPR motif; other site 423368004518 binding surface 423368004519 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 423368004520 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 423368004521 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 423368004522 type III secretion system protein SsaH; Provisional; Region: PRK15356 423368004523 type III secretion system protein SsaI; Provisional; Region: PRK15355 423368004524 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 423368004525 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 423368004526 type III secretion system protein SsaK; Provisional; Region: PRK15354 423368004527 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 423368004528 type III secretion system protein SsaL; Provisional; Region: PRK15345 423368004529 HrpJ-like domain; Region: HrpJ; pfam07201 423368004530 TyeA; Region: TyeA; cl07611 423368004531 type III secretion system protein SsaM; Provisional; Region: PRK15353 423368004532 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 423368004533 FHIPEP family; Region: FHIPEP; pfam00771 423368004534 type III secretion system ATPase SsaN; Validated; Region: PRK07594 423368004535 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 423368004536 Walker A motif; other site 423368004537 ATP binding site [chemical binding]; other site 423368004538 Walker B motif; other site 423368004539 type III secretion system protein SsaO; Provisional; Region: PRK15352 423368004540 type III secretion system protein SsaP; Provisional; Region: PRK15351 423368004541 type III secretion system protein SsaQ; Validated; Region: PRK08035 423368004542 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 423368004543 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 423368004544 type III secretion system protein SsaT; Provisional; Region: PRK15349 423368004545 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 423368004546 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 423368004547 multidrug efflux protein; Reviewed; Region: PRK01766 423368004548 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 423368004549 cation binding site [ion binding]; other site 423368004550 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 423368004551 Lumazine binding domain; Region: Lum_binding; pfam00677 423368004552 Lumazine binding domain; Region: Lum_binding; pfam00677 423368004553 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 423368004554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368004555 S-adenosylmethionine binding site [chemical binding]; other site 423368004556 putative transporter; Provisional; Region: PRK11043 423368004557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004558 putative substrate translocation pore; other site 423368004559 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 423368004560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368004561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368004562 dimerization interface [polypeptide binding]; other site 423368004563 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 423368004564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368004565 DNA binding site [nucleotide binding] 423368004566 domain linker motif; other site 423368004567 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 423368004568 dimerization interface [polypeptide binding]; other site 423368004569 ligand binding site [chemical binding]; other site 423368004570 superoxide dismutase; Provisional; Region: PRK10543 423368004571 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 423368004572 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 423368004573 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 423368004574 NlpC/P60 family; Region: NLPC_P60; pfam00877 423368004575 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 423368004576 putative GSH binding site [chemical binding]; other site 423368004577 catalytic residues [active] 423368004578 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 423368004579 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 423368004580 dimer interface [polypeptide binding]; other site 423368004581 catalytic site [active] 423368004582 putative active site [active] 423368004583 putative substrate binding site [chemical binding]; other site 423368004584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 423368004585 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 423368004586 dimer interface [polypeptide binding]; other site 423368004587 active site 423368004588 metal binding site [ion binding]; metal-binding site 423368004589 glutathione binding site [chemical binding]; other site 423368004590 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 423368004591 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 423368004592 FMN binding site [chemical binding]; other site 423368004593 active site 423368004594 substrate binding site [chemical binding]; other site 423368004595 catalytic residue [active] 423368004596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 423368004597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368004598 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 423368004599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368004600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368004601 active site 423368004602 catalytic tetrad [active] 423368004603 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 423368004604 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 423368004605 E-class dimer interface [polypeptide binding]; other site 423368004606 P-class dimer interface [polypeptide binding]; other site 423368004607 active site 423368004608 Cu2+ binding site [ion binding]; other site 423368004609 Zn2+ binding site [ion binding]; other site 423368004610 Fusaric acid resistance protein family; Region: FUSC; pfam04632 423368004611 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 423368004612 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 423368004613 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368004614 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368004615 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 423368004616 transcriptional regulator SlyA; Provisional; Region: PRK03573 423368004617 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 423368004618 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 423368004619 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 423368004620 lysozyme inhibitor; Provisional; Region: PRK11372 423368004621 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 423368004622 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 423368004623 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 423368004624 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 423368004625 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 423368004626 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 423368004627 active site 423368004628 HIGH motif; other site 423368004629 dimer interface [polypeptide binding]; other site 423368004630 KMSKS motif; other site 423368004631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368004632 RNA binding surface [nucleotide binding]; other site 423368004633 pyridoxamine kinase; Validated; Region: PRK05756 423368004634 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 423368004635 dimer interface [polypeptide binding]; other site 423368004636 pyridoxal binding site [chemical binding]; other site 423368004637 ATP binding site [chemical binding]; other site 423368004638 glutathionine S-transferase; Provisional; Region: PRK10542 423368004639 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 423368004640 C-terminal domain interface [polypeptide binding]; other site 423368004641 GSH binding site (G-site) [chemical binding]; other site 423368004642 dimer interface [polypeptide binding]; other site 423368004643 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 423368004644 dimer interface [polypeptide binding]; other site 423368004645 N-terminal domain interface [polypeptide binding]; other site 423368004646 substrate binding pocket (H-site) [chemical binding]; other site 423368004647 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 423368004648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004649 putative substrate translocation pore; other site 423368004650 POT family; Region: PTR2; pfam00854 423368004651 endonuclease III; Provisional; Region: PRK10702 423368004652 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 423368004653 minor groove reading motif; other site 423368004654 helix-hairpin-helix signature motif; other site 423368004655 substrate binding pocket [chemical binding]; other site 423368004656 active site 423368004657 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 423368004658 electron transport complex RsxE subunit; Provisional; Region: PRK12405 423368004659 electron transport complex protein RnfG; Validated; Region: PRK01908 423368004660 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 423368004661 electron transport complex protein RnfC; Provisional; Region: PRK05035 423368004662 SLBB domain; Region: SLBB; pfam10531 423368004663 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368004664 electron transport complex protein RnfB; Provisional; Region: PRK05113 423368004665 Putative Fe-S cluster; Region: FeS; cl17515 423368004666 4Fe-4S binding domain; Region: Fer4; pfam00037 423368004667 electron transport complex protein RsxA; Provisional; Region: PRK05151 423368004668 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 423368004669 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 423368004670 putative oxidoreductase; Provisional; Region: PRK11579 423368004671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 423368004672 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 423368004673 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 423368004674 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 423368004675 active site 423368004676 purine riboside binding site [chemical binding]; other site 423368004677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 423368004678 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 423368004679 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 423368004680 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 423368004681 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 423368004682 fumarate hydratase; Provisional; Region: PRK15389 423368004683 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 423368004684 Fumarase C-terminus; Region: Fumerase_C; pfam05683 423368004685 fumarate hydratase; Reviewed; Region: fumC; PRK00485 423368004686 Class II fumarases; Region: Fumarase_classII; cd01362 423368004687 active site 423368004688 tetramer interface [polypeptide binding]; other site 423368004689 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 423368004690 sensor protein RstB; Provisional; Region: PRK10604 423368004691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368004692 dimerization interface [polypeptide binding]; other site 423368004693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368004694 dimer interface [polypeptide binding]; other site 423368004695 phosphorylation site [posttranslational modification] 423368004696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368004697 ATP binding site [chemical binding]; other site 423368004698 Mg2+ binding site [ion binding]; other site 423368004699 G-X-G motif; other site 423368004700 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 423368004701 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 423368004702 active site 423368004703 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368004704 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368004705 trimer interface [polypeptide binding]; other site 423368004706 eyelet of channel; other site 423368004707 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 423368004708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368004709 active site 423368004710 phosphorylation site [posttranslational modification] 423368004711 intermolecular recognition site; other site 423368004712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368004713 DNA binding site [nucleotide binding] 423368004714 GlpM protein; Region: GlpM; pfam06942 423368004715 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 423368004716 Spore germination protein; Region: Spore_permease; cl17796 423368004717 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368004718 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368004719 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368004720 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 423368004721 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 423368004722 ligand binding site [chemical binding]; other site 423368004723 homodimer interface [polypeptide binding]; other site 423368004724 NAD(P) binding site [chemical binding]; other site 423368004725 trimer interface B [polypeptide binding]; other site 423368004726 trimer interface A [polypeptide binding]; other site 423368004727 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 423368004728 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 423368004729 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 423368004730 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 423368004731 Domain of unknown function DUF20; Region: UPF0118; pfam01594 423368004732 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 423368004733 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 423368004734 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 423368004735 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 423368004736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004737 putative substrate translocation pore; other site 423368004738 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 423368004739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368004740 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 423368004741 dimerization interface [polypeptide binding]; other site 423368004742 substrate binding pocket [chemical binding]; other site 423368004743 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 423368004744 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 423368004745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368004746 putative dithiobiotin synthetase; Provisional; Region: PRK12374 423368004747 AAA domain; Region: AAA_26; pfam13500 423368004748 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 423368004749 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 423368004750 Cl- selectivity filter; other site 423368004751 Cl- binding residues [ion binding]; other site 423368004752 pore gating glutamate residue; other site 423368004753 dimer interface [polypeptide binding]; other site 423368004754 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 423368004755 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 423368004756 Walker A/P-loop; other site 423368004757 ATP binding site [chemical binding]; other site 423368004758 Q-loop/lid; other site 423368004759 ABC transporter signature motif; other site 423368004760 Walker B; other site 423368004761 D-loop; other site 423368004762 H-loop/switch region; other site 423368004763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 423368004764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368004765 dimer interface [polypeptide binding]; other site 423368004766 conserved gate region; other site 423368004767 ABC-ATPase subunit interface; other site 423368004768 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 423368004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368004770 dimer interface [polypeptide binding]; other site 423368004771 conserved gate region; other site 423368004772 putative PBP binding loops; other site 423368004773 ABC-ATPase subunit interface; other site 423368004774 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 423368004775 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 423368004776 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 423368004777 4Fe-4S binding domain; Region: Fer4; pfam00037 423368004778 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 423368004779 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 423368004780 putative [Fe4-S4] binding site [ion binding]; other site 423368004781 putative molybdopterin cofactor binding site [chemical binding]; other site 423368004782 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 423368004783 putative molybdopterin cofactor binding site; other site 423368004784 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 423368004785 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 423368004786 putative [Fe4-S4] binding site [ion binding]; other site 423368004787 putative molybdopterin cofactor binding site [chemical binding]; other site 423368004788 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 423368004789 putative molybdopterin cofactor binding site; other site 423368004790 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 423368004791 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 423368004792 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 423368004793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368004794 Coenzyme A binding pocket [chemical binding]; other site 423368004795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 423368004796 hypothetical protein; Provisional; Region: PRK13659 423368004797 hypothetical protein; Provisional; Region: PRK02237 423368004798 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 423368004799 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 423368004800 putative active site pocket [active] 423368004801 putative metal binding site [ion binding]; other site 423368004802 putative oxidoreductase; Provisional; Region: PRK10083 423368004803 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 423368004804 putative NAD(P) binding site [chemical binding]; other site 423368004805 catalytic Zn binding site [ion binding]; other site 423368004806 structural Zn binding site [ion binding]; other site 423368004807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004808 metabolite-proton symporter; Region: 2A0106; TIGR00883 423368004809 putative substrate translocation pore; other site 423368004810 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 423368004811 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 423368004812 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 423368004813 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 423368004814 Transcriptional regulators [Transcription]; Region: GntR; COG1802 423368004815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368004816 DNA-binding site [nucleotide binding]; DNA binding site 423368004817 FCD domain; Region: FCD; pfam07729 423368004818 malonic semialdehyde reductase; Provisional; Region: PRK10538 423368004819 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 423368004820 putative NAD(P) binding site [chemical binding]; other site 423368004821 homodimer interface [polypeptide binding]; other site 423368004822 homotetramer interface [polypeptide binding]; other site 423368004823 active site 423368004824 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 423368004825 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 423368004826 active site 423368004827 Zn binding site [ion binding]; other site 423368004828 General stress protein [General function prediction only]; Region: GsiB; COG3729 423368004829 hypothetical protein; Validated; Region: PRK03657 423368004830 hypothetical protein; Provisional; Region: PRK10053 423368004831 putative transporter; Provisional; Region: PRK10054 423368004832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004833 putative substrate translocation pore; other site 423368004834 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 423368004835 EamA-like transporter family; Region: EamA; pfam00892 423368004836 MarB protein; Region: MarB; pfam13999 423368004837 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 423368004838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368004839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368004840 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 423368004841 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 423368004842 inner membrane protein; Provisional; Region: PRK10995 423368004843 putative arabinose transporter; Provisional; Region: PRK03545 423368004844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004845 putative substrate translocation pore; other site 423368004846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368004847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368004848 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 423368004849 putative dimerization interface [polypeptide binding]; other site 423368004850 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 423368004851 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 423368004852 NAD(P) binding site [chemical binding]; other site 423368004853 catalytic residues [active] 423368004854 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 423368004855 glutaminase; Provisional; Region: PRK00971 423368004856 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 423368004857 Predicted membrane protein [Function unknown]; Region: COG3781 423368004858 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 423368004859 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368004860 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368004861 trimer interface [polypeptide binding]; other site 423368004862 eyelet of channel; other site 423368004863 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 423368004864 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 423368004865 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 423368004866 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 423368004867 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 423368004868 Rubredoxin [Energy production and conversion]; Region: COG1773 423368004869 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 423368004870 iron binding site [ion binding]; other site 423368004871 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 423368004872 HupF/HypC family; Region: HupF_HypC; cl00394 423368004873 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 423368004874 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 423368004875 putative substrate-binding site; other site 423368004876 nickel binding site [ion binding]; other site 423368004877 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 423368004878 hydrogenase 1 large subunit; Provisional; Region: PRK10170 423368004879 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 423368004880 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 423368004881 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 423368004882 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 423368004883 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 423368004884 active site 423368004885 Transcriptional regulators [Transcription]; Region: FadR; COG2186 423368004886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368004887 DNA-binding site [nucleotide binding]; DNA binding site 423368004888 FCD domain; Region: FCD; pfam07729 423368004889 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 423368004890 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 423368004891 putative NAD(P) binding site [chemical binding]; other site 423368004892 catalytic Zn binding site [ion binding]; other site 423368004893 structural Zn binding site [ion binding]; other site 423368004894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004895 D-galactonate transporter; Region: 2A0114; TIGR00893 423368004896 putative substrate translocation pore; other site 423368004897 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 423368004898 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 423368004899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368004901 putative substrate translocation pore; other site 423368004902 hypothetical protein; Provisional; Region: PRK06184 423368004903 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 423368004904 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 423368004905 Transcriptional regulators [Transcription]; Region: MarR; COG1846 423368004906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368004907 putative DNA binding site [nucleotide binding]; other site 423368004908 putative Zn2+ binding site [ion binding]; other site 423368004909 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 423368004910 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 423368004911 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 423368004912 homotrimer interaction site [polypeptide binding]; other site 423368004913 putative active site [active] 423368004914 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 423368004915 Domain of unknown function DUF29; Region: DUF29; pfam01724 423368004916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368004917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 423368004918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368004919 DNA binding site [nucleotide binding] 423368004920 domain linker motif; other site 423368004921 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 423368004922 dimerization interface (closed form) [polypeptide binding]; other site 423368004923 ligand binding site [chemical binding]; other site 423368004924 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 423368004925 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 423368004926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368004927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368004928 homodimer interface [polypeptide binding]; other site 423368004929 catalytic residue [active] 423368004930 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 423368004931 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 423368004932 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 423368004933 active site 423368004934 catalytic site [active] 423368004935 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 423368004936 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 423368004937 active site 423368004938 catalytic site [active] 423368004939 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 423368004940 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 423368004941 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 423368004942 catalytic site [active] 423368004943 active site 423368004944 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 423368004945 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 423368004946 acid-resistance protein; Provisional; Region: hdeB; PRK11566 423368004947 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 423368004948 biofilm-dependent modulation protein; Provisional; Region: PRK11436 423368004949 malate dehydrogenase; Provisional; Region: PRK13529 423368004950 Malic enzyme, N-terminal domain; Region: malic; pfam00390 423368004951 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 423368004952 NAD(P) binding site [chemical binding]; other site 423368004953 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 423368004954 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 423368004955 NAD binding site [chemical binding]; other site 423368004956 substrate binding site [chemical binding]; other site 423368004957 catalytic Zn binding site [ion binding]; other site 423368004958 tetramer interface [polypeptide binding]; other site 423368004959 structural Zn binding site [ion binding]; other site 423368004960 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 423368004961 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 423368004962 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 423368004963 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 423368004964 aromatic amino acid exporter; Provisional; Region: PRK11689 423368004965 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368004966 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368004967 trimer interface [polypeptide binding]; other site 423368004968 eyelet of channel; other site 423368004969 Uncharacterized conserved protein [Function unknown]; Region: COG3791 423368004970 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 423368004971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368004972 putative substrate translocation pore; other site 423368004973 TetR family transcriptional regulator; Provisional; Region: PRK14996 423368004974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368004975 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 423368004976 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 423368004977 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 423368004978 [4Fe-4S] binding site [ion binding]; other site 423368004979 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 423368004980 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 423368004981 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 423368004982 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 423368004983 molybdopterin cofactor binding site; other site 423368004984 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 423368004985 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 423368004986 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 423368004987 hypothetical protein; Provisional; Region: PRK10281 423368004988 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 423368004989 L-asparagine permease; Provisional; Region: PRK15049 423368004990 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 423368004991 Uncharacterized conserved protein [Function unknown]; Region: COG3391 423368004992 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 423368004993 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 423368004994 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368004995 N-terminal plug; other site 423368004996 ligand-binding site [chemical binding]; other site 423368004997 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 423368004998 DNA-binding site [nucleotide binding]; DNA binding site 423368004999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 423368005000 FCD domain; Region: FCD; pfam07729 423368005001 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 423368005002 Prostaglandin dehydrogenases; Region: PGDH; cd05288 423368005003 NAD(P) binding site [chemical binding]; other site 423368005004 substrate binding site [chemical binding]; other site 423368005005 dimer interface [polypeptide binding]; other site 423368005006 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 423368005007 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 423368005008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 423368005009 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 423368005010 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 423368005011 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 423368005012 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 423368005013 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 423368005014 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 423368005015 tetrameric interface [polypeptide binding]; other site 423368005016 NAD binding site [chemical binding]; other site 423368005017 catalytic residues [active] 423368005018 substrate binding site [chemical binding]; other site 423368005019 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 423368005020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368005021 DNA-binding site [nucleotide binding]; DNA binding site 423368005022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368005023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368005024 homodimer interface [polypeptide binding]; other site 423368005025 catalytic residue [active] 423368005026 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 423368005027 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 423368005028 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 423368005029 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 423368005030 Peptidase family U32; Region: Peptidase_U32; pfam01136 423368005031 Collagenase; Region: DUF3656; pfam12392 423368005032 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 423368005033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368005034 non-specific DNA binding site [nucleotide binding]; other site 423368005035 salt bridge; other site 423368005036 sequence-specific DNA binding site [nucleotide binding]; other site 423368005037 Cupin domain; Region: Cupin_2; pfam07883 423368005038 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 423368005039 benzoate transporter; Region: benE; TIGR00843 423368005040 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 423368005041 tellurite resistance protein TehB; Provisional; Region: PRK11207 423368005042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368005043 S-adenosylmethionine binding site [chemical binding]; other site 423368005044 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 423368005045 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 423368005046 gating phenylalanine in ion channel; other site 423368005047 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 423368005048 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 423368005049 putative trimer interface [polypeptide binding]; other site 423368005050 putative CoA binding site [chemical binding]; other site 423368005051 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 423368005052 putative trimer interface [polypeptide binding]; other site 423368005053 putative CoA binding site [chemical binding]; other site 423368005054 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 423368005055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368005056 Coenzyme A binding pocket [chemical binding]; other site 423368005057 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 423368005058 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 423368005059 oligomer interface [polypeptide binding]; other site 423368005060 active site 423368005061 metal binding site [ion binding]; metal-binding site 423368005062 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 423368005063 active site 423368005064 P-loop; other site 423368005065 phosphorylation site [posttranslational modification] 423368005066 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 423368005067 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 423368005068 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 423368005069 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368005070 active site 423368005071 phosphorylation site [posttranslational modification] 423368005072 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 423368005073 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 423368005074 substrate binding site [chemical binding]; other site 423368005075 hexamer interface [polypeptide binding]; other site 423368005076 metal binding site [ion binding]; metal-binding site 423368005077 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368005078 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 423368005079 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368005080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368005081 Coenzyme A binding pocket [chemical binding]; other site 423368005082 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 423368005083 teramer interface [polypeptide binding]; other site 423368005084 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 423368005085 active site 423368005086 FMN binding site [chemical binding]; other site 423368005087 catalytic residues [active] 423368005088 Uncharacterized conserved protein [Function unknown]; Region: COG2353 423368005089 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 423368005090 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 423368005091 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 423368005092 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 423368005093 substrate binding pocket [chemical binding]; other site 423368005094 catalytic triad [active] 423368005095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 423368005096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 423368005097 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 423368005098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368005099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368005100 dimerization interface [polypeptide binding]; other site 423368005101 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 423368005102 dimer interface [polypeptide binding]; other site 423368005103 ligand binding site [chemical binding]; other site 423368005104 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 423368005105 HAMP domain; Region: HAMP; pfam00672 423368005106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368005107 dimer interface [polypeptide binding]; other site 423368005108 putative CheW interface [polypeptide binding]; other site 423368005109 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 423368005110 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 423368005111 substrate binding site [chemical binding]; other site 423368005112 catalytic Zn binding site [ion binding]; other site 423368005113 NAD binding site [chemical binding]; other site 423368005114 structural Zn binding site [ion binding]; other site 423368005115 dimer interface [polypeptide binding]; other site 423368005116 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 423368005117 putative metal binding site [ion binding]; other site 423368005118 putative homodimer interface [polypeptide binding]; other site 423368005119 putative homotetramer interface [polypeptide binding]; other site 423368005120 putative homodimer-homodimer interface [polypeptide binding]; other site 423368005121 putative allosteric switch controlling residues; other site 423368005122 Sif protein; Region: Sif; cl11505 423368005123 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 423368005124 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 423368005125 active site 423368005126 catalytic triad [active] 423368005127 oxyanion hole [active] 423368005128 Predicted membrane protein [Function unknown]; Region: COG3326 423368005129 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368005130 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 423368005131 substrate binding pocket [chemical binding]; other site 423368005132 membrane-bound complex binding site; other site 423368005133 hinge residues; other site 423368005134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368005135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368005136 dimer interface [polypeptide binding]; other site 423368005137 conserved gate region; other site 423368005138 putative PBP binding loops; other site 423368005139 ABC-ATPase subunit interface; other site 423368005140 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 423368005141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368005142 Walker A/P-loop; other site 423368005143 ATP binding site [chemical binding]; other site 423368005144 Q-loop/lid; other site 423368005145 ABC transporter signature motif; other site 423368005146 Walker B; other site 423368005147 D-loop; other site 423368005148 H-loop/switch region; other site 423368005149 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368005151 dimer interface [polypeptide binding]; other site 423368005152 conserved gate region; other site 423368005153 putative PBP binding loops; other site 423368005154 ABC-ATPase subunit interface; other site 423368005155 Predicted membrane protein [Function unknown]; Region: COG5305 423368005156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368005157 S-adenosylmethionine binding site [chemical binding]; other site 423368005158 cytochrome b561; Provisional; Region: PRK11513 423368005159 Uncharacterized conserved protein [Function unknown]; Region: COG1434 423368005160 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 423368005161 putative active site [active] 423368005162 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 423368005163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368005164 ATP binding site [chemical binding]; other site 423368005165 putative Mg++ binding site [ion binding]; other site 423368005166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368005167 nucleotide binding region [chemical binding]; other site 423368005168 ATP-binding site [chemical binding]; other site 423368005169 Helicase associated domain (HA2); Region: HA2; pfam04408 423368005170 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 423368005171 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 423368005172 azoreductase; Reviewed; Region: PRK00170 423368005173 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 423368005174 Uncharacterized conserved protein [Function unknown]; Region: COG3791 423368005175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 423368005176 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 423368005177 hypothetical protein; Provisional; Region: PRK10695 423368005178 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 423368005179 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 423368005180 putative ligand binding site [chemical binding]; other site 423368005181 putative NAD binding site [chemical binding]; other site 423368005182 catalytic site [active] 423368005183 heat-inducible protein; Provisional; Region: PRK10449 423368005184 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 423368005185 Domain of unknown function (DUF333); Region: DUF333; pfam03891 423368005186 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 423368005187 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 423368005188 dimer interface [polypeptide binding]; other site 423368005189 PYR/PP interface [polypeptide binding]; other site 423368005190 TPP binding site [chemical binding]; other site 423368005191 substrate binding site [chemical binding]; other site 423368005192 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 423368005193 Domain of unknown function; Region: EKR; smart00890 423368005194 4Fe-4S binding domain; Region: Fer4_6; pfam12837 423368005195 4Fe-4S binding domain; Region: Fer4; pfam00037 423368005196 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 423368005197 TPP-binding site [chemical binding]; other site 423368005198 dimer interface [polypeptide binding]; other site 423368005199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 423368005200 Ligand Binding Site [chemical binding]; other site 423368005201 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 423368005202 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 423368005203 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 423368005204 Ligand Binding Site [chemical binding]; other site 423368005205 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 423368005206 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 423368005207 ATP binding site [chemical binding]; other site 423368005208 Mg++ binding site [ion binding]; other site 423368005209 motif III; other site 423368005210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368005211 nucleotide binding region [chemical binding]; other site 423368005212 ATP-binding site [chemical binding]; other site 423368005213 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 423368005214 putative RNA binding site [nucleotide binding]; other site 423368005215 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 423368005216 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 423368005217 Cl binding site [ion binding]; other site 423368005218 oligomer interface [polypeptide binding]; other site 423368005219 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 423368005220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368005221 dimer interface [polypeptide binding]; other site 423368005222 putative CheW interface [polypeptide binding]; other site 423368005223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 423368005224 Smr domain; Region: Smr; pfam01713 423368005225 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 423368005226 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 423368005227 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 423368005228 DNA binding site [nucleotide binding] 423368005229 active site 423368005230 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 423368005231 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 423368005232 ligand binding site [chemical binding]; other site 423368005233 flexible hinge region; other site 423368005234 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 423368005235 putative switch regulator; other site 423368005236 non-specific DNA interactions [nucleotide binding]; other site 423368005237 DNA binding site [nucleotide binding] 423368005238 sequence specific DNA binding site [nucleotide binding]; other site 423368005239 putative cAMP binding site [chemical binding]; other site 423368005240 universal stress protein UspE; Provisional; Region: PRK11175 423368005241 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 423368005242 Ligand Binding Site [chemical binding]; other site 423368005243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 423368005244 Ligand Binding Site [chemical binding]; other site 423368005245 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 423368005246 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 423368005247 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368005248 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 423368005249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368005250 non-specific DNA binding site [nucleotide binding]; other site 423368005251 salt bridge; other site 423368005252 sequence-specific DNA binding site [nucleotide binding]; other site 423368005253 Cupin domain; Region: Cupin_2; pfam07883 423368005254 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 423368005255 B3/4 domain; Region: B3_4; pfam03483 423368005256 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 423368005257 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 423368005258 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 423368005259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368005260 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 423368005261 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 423368005262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 423368005263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368005264 oxidoreductase; Provisional; Region: PRK12742 423368005265 classical (c) SDRs; Region: SDR_c; cd05233 423368005266 NAD(P) binding site [chemical binding]; other site 423368005267 active site 423368005268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368005269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368005270 active site 423368005271 catalytic tetrad [active] 423368005272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368005273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368005274 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 423368005275 putative effector binding pocket; other site 423368005276 putative dimerization interface [polypeptide binding]; other site 423368005277 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 423368005278 NmrA-like family; Region: NmrA; pfam05368 423368005279 NAD(P) binding site [chemical binding]; other site 423368005280 active site lysine 423368005281 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 423368005282 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 423368005283 peptide binding site [polypeptide binding]; other site 423368005284 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 423368005285 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 423368005286 putative active site [active] 423368005287 Zn binding site [ion binding]; other site 423368005288 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 423368005289 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 423368005290 active site 423368005291 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 423368005292 dimer interface [polypeptide binding]; other site 423368005293 catalytic triad [active] 423368005294 peroxidatic and resolving cysteines [active] 423368005295 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 423368005296 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 423368005297 putative aromatic amino acid binding site; other site 423368005298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368005299 Walker A motif; other site 423368005300 ATP binding site [chemical binding]; other site 423368005301 Walker B motif; other site 423368005302 arginine finger; other site 423368005303 hypothetical protein; Provisional; Region: PRK05415 423368005304 TIGR01620 family protein; Region: hyp_HI0043 423368005305 Predicted ATPase [General function prediction only]; Region: COG3106 423368005306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 423368005307 active site residue [active] 423368005308 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 423368005309 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 423368005310 phage shock protein C; Region: phageshock_pspC; TIGR02978 423368005311 phage shock protein B; Provisional; Region: pspB; PRK09458 423368005312 phage shock protein PspA; Provisional; Region: PRK10698 423368005313 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 423368005314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368005315 Walker A motif; other site 423368005316 ATP binding site [chemical binding]; other site 423368005317 Walker B motif; other site 423368005318 arginine finger; other site 423368005319 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 423368005320 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 423368005321 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 423368005322 peptide binding site [polypeptide binding]; other site 423368005323 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 423368005324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368005325 dimer interface [polypeptide binding]; other site 423368005326 conserved gate region; other site 423368005327 putative PBP binding loops; other site 423368005328 ABC-ATPase subunit interface; other site 423368005329 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 423368005330 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 423368005331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368005332 dimer interface [polypeptide binding]; other site 423368005333 conserved gate region; other site 423368005334 putative PBP binding loops; other site 423368005335 ABC-ATPase subunit interface; other site 423368005336 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 423368005337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368005338 Walker A/P-loop; other site 423368005339 ATP binding site [chemical binding]; other site 423368005340 Q-loop/lid; other site 423368005341 ABC transporter signature motif; other site 423368005342 Walker B; other site 423368005343 D-loop; other site 423368005344 H-loop/switch region; other site 423368005345 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 423368005346 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 423368005347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368005348 Walker A/P-loop; other site 423368005349 ATP binding site [chemical binding]; other site 423368005350 Q-loop/lid; other site 423368005351 ABC transporter signature motif; other site 423368005352 Walker B; other site 423368005353 D-loop; other site 423368005354 H-loop/switch region; other site 423368005355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 423368005356 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 423368005357 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 423368005358 NAD binding site [chemical binding]; other site 423368005359 homotetramer interface [polypeptide binding]; other site 423368005360 homodimer interface [polypeptide binding]; other site 423368005361 substrate binding site [chemical binding]; other site 423368005362 active site 423368005363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 423368005364 Uncharacterized conserved protein [Function unknown]; Region: COG2128 423368005365 exoribonuclease II; Provisional; Region: PRK05054 423368005366 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 423368005367 RNB domain; Region: RNB; pfam00773 423368005368 S1 RNA binding domain; Region: S1; pfam00575 423368005369 RNase II stability modulator; Provisional; Region: PRK10060 423368005370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368005371 putative active site [active] 423368005372 heme pocket [chemical binding]; other site 423368005373 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368005374 metal binding site [ion binding]; metal-binding site 423368005375 active site 423368005376 I-site; other site 423368005377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368005378 hypothetical protein; Provisional; Region: PRK13658 423368005379 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368005380 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368005381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368005382 lipoprotein; Provisional; Region: PRK10540 423368005383 translation initiation factor Sui1; Validated; Region: PRK06824 423368005384 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 423368005385 putative rRNA binding site [nucleotide binding]; other site 423368005386 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 423368005387 active site 423368005388 dimer interface [polypeptide binding]; other site 423368005389 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 423368005390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 423368005391 binding surface 423368005392 TPR motif; other site 423368005393 Predicted membrane protein [Function unknown]; Region: COG3771 423368005394 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 423368005395 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 423368005396 active site 423368005397 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 423368005398 dimerization interface [polypeptide binding]; other site 423368005399 active site 423368005400 aconitate hydratase; Validated; Region: PRK09277 423368005401 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 423368005402 substrate binding site [chemical binding]; other site 423368005403 ligand binding site [chemical binding]; other site 423368005404 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 423368005405 substrate binding site [chemical binding]; other site 423368005406 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 423368005407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368005408 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 423368005409 substrate binding site [chemical binding]; other site 423368005410 putative dimerization interface [polypeptide binding]; other site 423368005411 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 423368005412 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 423368005413 active site 423368005414 interdomain interaction site; other site 423368005415 putative metal-binding site [ion binding]; other site 423368005416 nucleotide binding site [chemical binding]; other site 423368005417 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 423368005418 domain I; other site 423368005419 DNA binding groove [nucleotide binding] 423368005420 phosphate binding site [ion binding]; other site 423368005421 domain II; other site 423368005422 domain III; other site 423368005423 nucleotide binding site [chemical binding]; other site 423368005424 catalytic site [active] 423368005425 domain IV; other site 423368005426 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368005427 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368005428 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 423368005429 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 423368005430 hypothetical protein; Provisional; Region: PRK11037 423368005431 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 423368005432 putative inner membrane peptidase; Provisional; Region: PRK11778 423368005433 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 423368005434 tandem repeat interface [polypeptide binding]; other site 423368005435 oligomer interface [polypeptide binding]; other site 423368005436 active site residues [active] 423368005437 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 423368005438 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 423368005439 NADP binding site [chemical binding]; other site 423368005440 homodimer interface [polypeptide binding]; other site 423368005441 active site 423368005442 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 423368005443 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 423368005444 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 423368005445 homodimer interface [polypeptide binding]; other site 423368005446 Walker A motif; other site 423368005447 ATP binding site [chemical binding]; other site 423368005448 hydroxycobalamin binding site [chemical binding]; other site 423368005449 Walker B motif; other site 423368005450 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 423368005451 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368005452 RNA binding surface [nucleotide binding]; other site 423368005453 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 423368005454 probable active site [active] 423368005455 hypothetical protein; Provisional; Region: PRK11630 423368005456 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 423368005457 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 423368005458 active site 423368005459 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 423368005460 Tryptophan operon leader 423368005461 anthranilate synthase component I; Provisional; Region: PRK13564 423368005462 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 423368005463 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 423368005464 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 423368005465 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 423368005466 glutamine binding [chemical binding]; other site 423368005467 catalytic triad [active] 423368005468 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 423368005469 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 423368005470 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 423368005471 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 423368005472 active site 423368005473 ribulose/triose binding site [chemical binding]; other site 423368005474 phosphate binding site [ion binding]; other site 423368005475 substrate (anthranilate) binding pocket [chemical binding]; other site 423368005476 product (indole) binding pocket [chemical binding]; other site 423368005477 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 423368005478 active site 423368005479 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 423368005480 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 423368005481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368005482 catalytic residue [active] 423368005483 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 423368005484 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 423368005485 substrate binding site [chemical binding]; other site 423368005486 active site 423368005487 catalytic residues [active] 423368005488 heterodimer interface [polypeptide binding]; other site 423368005489 General stress protein [General function prediction only]; Region: GsiB; COG3729 423368005490 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 423368005491 dimerization interface [polypeptide binding]; other site 423368005492 metal binding site [ion binding]; metal-binding site 423368005493 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 423368005494 dinuclear metal binding motif [ion binding]; other site 423368005495 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 423368005496 dimanganese center [ion binding]; other site 423368005497 outer membrane protein W; Provisional; Region: PRK10959 423368005498 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 423368005499 hypothetical protein; Provisional; Region: PRK02868 423368005500 intracellular septation protein A; Reviewed; Region: PRK00259 423368005501 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 423368005502 transport protein TonB; Provisional; Region: PRK10819 423368005503 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 423368005504 YciI-like protein; Reviewed; Region: PRK11370 423368005505 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 423368005506 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 423368005507 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 423368005508 putative active site [active] 423368005509 catalytic site [active] 423368005510 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 423368005511 putative active site [active] 423368005512 catalytic site [active] 423368005513 dsDNA-mimic protein; Reviewed; Region: PRK05094 423368005514 Ion transport protein; Region: Ion_trans; pfam00520 423368005515 Ion channel; Region: Ion_trans_2; pfam07885 423368005516 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 423368005517 Double zinc ribbon; Region: DZR; pfam12773 423368005518 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 423368005519 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368005520 Walker A/P-loop; other site 423368005521 ATP binding site [chemical binding]; other site 423368005522 Q-loop/lid; other site 423368005523 ABC transporter signature motif; other site 423368005524 Walker B; other site 423368005525 D-loop; other site 423368005526 H-loop/switch region; other site 423368005527 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 423368005528 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 423368005529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368005530 Walker A/P-loop; other site 423368005531 ATP binding site [chemical binding]; other site 423368005532 Q-loop/lid; other site 423368005533 ABC transporter signature motif; other site 423368005534 Walker B; other site 423368005535 D-loop; other site 423368005536 H-loop/switch region; other site 423368005537 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 423368005538 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 423368005539 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 423368005540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368005541 dimer interface [polypeptide binding]; other site 423368005542 conserved gate region; other site 423368005543 ABC-ATPase subunit interface; other site 423368005544 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 423368005545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368005546 dimer interface [polypeptide binding]; other site 423368005547 conserved gate region; other site 423368005548 putative PBP binding loops; other site 423368005549 ABC-ATPase subunit interface; other site 423368005550 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 423368005551 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 423368005552 peptide binding site [polypeptide binding]; other site 423368005553 hypothetical protein; Provisional; Region: PRK11111 423368005554 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 423368005555 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 423368005556 putative catalytic cysteine [active] 423368005557 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 423368005558 putative active site [active] 423368005559 metal binding site [ion binding]; metal-binding site 423368005560 thymidine kinase; Provisional; Region: PRK04296 423368005561 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 423368005562 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 423368005563 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 423368005564 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 423368005565 active site 423368005566 tetramer interface; other site 423368005567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368005568 active site 423368005569 response regulator of RpoS; Provisional; Region: PRK10693 423368005570 phosphorylation site [posttranslational modification] 423368005571 intermolecular recognition site; other site 423368005572 dimerization interface [polypeptide binding]; other site 423368005573 hypothetical protein; Provisional; Region: PRK10279 423368005574 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 423368005575 active site 423368005576 nucleophile elbow; other site 423368005577 SEC-C motif; Region: SEC-C; pfam02810 423368005578 hypothetical protein; Provisional; Region: PRK04233 423368005579 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 423368005580 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 423368005581 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 423368005582 putative active site [active] 423368005583 putative substrate binding site [chemical binding]; other site 423368005584 putative cosubstrate binding site; other site 423368005585 catalytic site [active] 423368005586 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368005587 Sel1-like repeats; Region: SEL1; smart00671 423368005588 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368005589 Sel1-like repeats; Region: SEL1; smart00671 423368005590 Sel1-like repeats; Region: SEL1; smart00671 423368005591 Sel1-like repeats; Region: SEL1; smart00671 423368005592 Sel1-like repeats; Region: SEL1; smart00671 423368005593 Sel1-like repeats; Region: SEL1; smart00671 423368005594 Sel1-like repeats; Region: SEL1; smart00671 423368005595 Sel1-like repeats; Region: SEL1; smart00671 423368005596 Sel1-like repeats; Region: SEL1; smart00671 423368005597 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 423368005598 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 423368005599 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 423368005600 4Fe-4S binding domain; Region: Fer4; cl02805 423368005601 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 423368005602 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 423368005603 [4Fe-4S] binding site [ion binding]; other site 423368005604 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 423368005605 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 423368005606 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 423368005607 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 423368005608 molybdopterin cofactor binding site; other site 423368005609 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 423368005610 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 423368005611 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 423368005612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368005613 dimerization interface [polypeptide binding]; other site 423368005614 Histidine kinase; Region: HisKA_3; pfam07730 423368005615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368005616 ATP binding site [chemical binding]; other site 423368005617 Mg2+ binding site [ion binding]; other site 423368005618 G-X-G motif; other site 423368005619 transcriptional regulator NarL; Provisional; Region: PRK10651 423368005620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368005621 active site 423368005622 phosphorylation site [posttranslational modification] 423368005623 intermolecular recognition site; other site 423368005624 dimerization interface [polypeptide binding]; other site 423368005625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368005626 DNA binding residues [nucleotide binding] 423368005627 dimerization interface [polypeptide binding]; other site 423368005628 putative invasin; Provisional; Region: PRK10177 423368005629 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 423368005630 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 423368005631 cation transport regulator; Reviewed; Region: chaB; PRK09582 423368005632 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 423368005633 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 423368005634 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 423368005635 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 423368005636 hypothetical protein; Provisional; Region: PRK10941 423368005637 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 423368005638 hypothetical protein; Provisional; Region: PRK10278 423368005639 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 423368005640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368005641 peptide chain release factor 1; Validated; Region: prfA; PRK00591 423368005642 This domain is found in peptide chain release factors; Region: PCRF; smart00937 423368005643 RF-1 domain; Region: RF-1; pfam00472 423368005644 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 423368005645 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 423368005646 tRNA; other site 423368005647 putative tRNA binding site [nucleotide binding]; other site 423368005648 putative NADP binding site [chemical binding]; other site 423368005649 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 423368005650 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 423368005651 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 423368005652 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 423368005653 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 423368005654 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 423368005655 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 423368005656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368005657 active site 423368005658 putative transporter; Provisional; Region: PRK11660 423368005659 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 423368005660 Sulfate transporter family; Region: Sulfate_transp; pfam00916 423368005661 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 423368005662 hypothetical protein; Provisional; Region: PRK10692 423368005663 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 423368005664 putative active site [active] 423368005665 catalytic residue [active] 423368005666 GTP-binding protein YchF; Reviewed; Region: PRK09601 423368005667 YchF GTPase; Region: YchF; cd01900 423368005668 G1 box; other site 423368005669 GTP/Mg2+ binding site [chemical binding]; other site 423368005670 Switch I region; other site 423368005671 G2 box; other site 423368005672 Switch II region; other site 423368005673 G3 box; other site 423368005674 G4 box; other site 423368005675 G5 box; other site 423368005676 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 423368005677 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 423368005678 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 423368005679 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 423368005680 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 423368005681 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 423368005682 hydrogenase 1 large subunit; Provisional; Region: PRK10170 423368005683 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 423368005684 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 423368005685 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 423368005686 putative substrate-binding site; other site 423368005687 nickel binding site [ion binding]; other site 423368005688 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 423368005689 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 423368005690 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 423368005691 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 423368005692 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 423368005693 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 423368005694 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 423368005695 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 423368005696 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 423368005697 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 423368005698 NAD(P) binding site [chemical binding]; other site 423368005699 trehalase; Provisional; Region: treA; PRK13271 423368005700 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 423368005701 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 423368005702 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 423368005703 Flagellar regulator YcgR; Region: YcgR; pfam07317 423368005704 PilZ domain; Region: PilZ; pfam07238 423368005705 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 423368005706 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368005707 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368005708 catalytic residue [active] 423368005709 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 423368005710 dimer interface [polypeptide binding]; other site 423368005711 catalytic triad [active] 423368005712 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 423368005713 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 423368005714 TrkA-C domain; Region: TrkA_C; pfam02080 423368005715 Transporter associated domain; Region: CorC_HlyC; smart01091 423368005716 alanine racemase; Reviewed; Region: dadX; PRK03646 423368005717 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 423368005718 active site 423368005719 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368005720 substrate binding site [chemical binding]; other site 423368005721 catalytic residues [active] 423368005722 dimer interface [polypeptide binding]; other site 423368005723 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 423368005724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 423368005725 SpoVR family protein; Provisional; Region: PRK11767 423368005726 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 423368005727 fatty acid metabolism regulator; Provisional; Region: PRK04984 423368005728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368005729 DNA-binding site [nucleotide binding]; DNA binding site 423368005730 FadR C-terminal domain; Region: FadR_C; pfam07840 423368005731 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 423368005732 transmembrane helices; other site 423368005733 disulfide bond formation protein B; Provisional; Region: PRK01749 423368005734 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 423368005735 GnsA/GnsB family; Region: GnsAB; pfam08178 423368005736 hypothetical protein; Provisional; Region: PRK05170 423368005737 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 423368005738 hypothetical protein; Provisional; Region: PRK10691 423368005739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 423368005740 septum formation inhibitor; Reviewed; Region: minC; PRK03511 423368005741 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 423368005742 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 423368005743 cell division inhibitor MinD; Provisional; Region: PRK10818 423368005744 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 423368005745 Switch I; other site 423368005746 Switch II; other site 423368005747 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 423368005748 ribonuclease D; Provisional; Region: PRK10829 423368005749 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 423368005750 catalytic site [active] 423368005751 putative active site [active] 423368005752 putative substrate binding site [chemical binding]; other site 423368005753 HRDC domain; Region: HRDC; cl02578 423368005754 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 423368005755 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 423368005756 acyl-activating enzyme (AAE) consensus motif; other site 423368005757 putative AMP binding site [chemical binding]; other site 423368005758 putative active site [active] 423368005759 putative CoA binding site [chemical binding]; other site 423368005760 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 423368005761 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 423368005762 Glycoprotease family; Region: Peptidase_M22; pfam00814 423368005763 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 423368005764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 423368005765 DEAD_2; Region: DEAD_2; pfam06733 423368005766 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 423368005767 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 423368005768 homotrimer interaction site [polypeptide binding]; other site 423368005769 putative active site [active] 423368005770 hypothetical protein; Provisional; Region: PRK05114 423368005771 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 423368005772 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 423368005773 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 423368005774 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 423368005775 putative active site [active] 423368005776 putative CoA binding site [chemical binding]; other site 423368005777 nudix motif; other site 423368005778 metal binding site [ion binding]; metal-binding site 423368005779 L-serine deaminase; Provisional; Region: PRK15023 423368005780 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 423368005781 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 423368005782 phage resistance protein; Provisional; Region: PRK10551 423368005783 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 423368005784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368005785 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 423368005786 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 423368005787 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 423368005788 Transporter associated domain; Region: CorC_HlyC; smart01091 423368005789 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 423368005790 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368005791 active pocket/dimerization site; other site 423368005792 active site 423368005793 phosphorylation site [posttranslational modification] 423368005794 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 423368005795 active site 423368005796 phosphorylation site [posttranslational modification] 423368005797 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 423368005798 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 423368005799 hypothetical protein; Provisional; Region: PRK02913 423368005800 yybP-ykoY leader 423368005801 hypothetical protein; Provisional; Region: PRK11469 423368005802 Domain of unknown function DUF; Region: DUF204; pfam02659 423368005803 Domain of unknown function DUF; Region: DUF204; pfam02659 423368005804 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 423368005805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368005806 S-adenosylmethionine binding site [chemical binding]; other site 423368005807 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 423368005808 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 423368005809 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 423368005810 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 423368005811 DNA-binding site [nucleotide binding]; DNA binding site 423368005812 RNA-binding motif; other site 423368005813 YebO-like protein; Region: YebO; pfam13974 423368005814 PhoPQ regulatory protein; Provisional; Region: PRK10299 423368005815 YobH-like protein; Region: YobH; pfam13996 423368005816 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 423368005817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368005818 dimerization interface [polypeptide binding]; other site 423368005819 putative Zn2+ binding site [ion binding]; other site 423368005820 putative DNA binding site [nucleotide binding]; other site 423368005821 Bacterial transcriptional regulator; Region: IclR; pfam01614 423368005822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368005823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368005824 putative substrate translocation pore; other site 423368005825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368005826 heat shock protein HtpX; Provisional; Region: PRK05457 423368005827 carboxy-terminal protease; Provisional; Region: PRK11186 423368005828 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 423368005829 protein binding site [polypeptide binding]; other site 423368005830 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 423368005831 Catalytic dyad [active] 423368005832 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 423368005833 ProP expression regulator; Provisional; Region: PRK04950 423368005834 ProQ/FINO family; Region: ProQ; pfam04352 423368005835 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 423368005836 GAF domain; Region: GAF_2; pfam13185 423368005837 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 423368005838 Paraquat-inducible protein A; Region: PqiA; pfam04403 423368005839 Paraquat-inducible protein A; Region: PqiA; pfam04403 423368005840 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 423368005841 mce related protein; Region: MCE; pfam02470 423368005842 mce related protein; Region: MCE; pfam02470 423368005843 mce related protein; Region: MCE; pfam02470 423368005844 mce related protein; Region: MCE; pfam02470 423368005845 mce related protein; Region: MCE; pfam02470 423368005846 mce related protein; Region: MCE; pfam02470 423368005847 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 423368005848 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 423368005849 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 423368005850 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 423368005851 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 423368005852 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 423368005853 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 423368005854 type III secretion protein SopE2; Provisional; Region: PRK15280 423368005855 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 423368005856 SopE GEF domain; Region: SopE_GEF; pfam07487 423368005857 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 423368005858 Fimbrial protein; Region: Fimbrial; cl01416 423368005859 PapC N-terminal domain; Region: PapC_N; pfam13954 423368005860 Acyltransferase family; Region: Acyl_transf_3; pfam01757 423368005861 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368005862 DNA binding site [nucleotide binding] 423368005863 active site 423368005864 Int/Topo IB signature motif; other site 423368005865 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 423368005866 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 423368005867 EamA-like transporter family; Region: EamA; pfam00892 423368005868 EamA-like transporter family; Region: EamA; pfam00892 423368005869 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 423368005870 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 423368005871 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 423368005872 ADP-ribose binding site [chemical binding]; other site 423368005873 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368005874 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 423368005875 exonuclease VIII; Reviewed; Region: PRK09709 423368005876 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 423368005877 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 423368005878 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 423368005879 dimer interface [polypeptide binding]; other site 423368005880 active site 423368005881 Int/Topo IB signature motif; other site 423368005882 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 423368005883 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 423368005884 hypothetical protein; Provisional; Region: PRK10301 423368005885 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 423368005886 Predicted amidohydrolase [General function prediction only]; Region: COG0388 423368005887 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 423368005888 exodeoxyribonuclease X; Provisional; Region: PRK07983 423368005889 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 423368005890 active site 423368005891 catalytic site [active] 423368005892 substrate binding site [chemical binding]; other site 423368005893 protease 2; Provisional; Region: PRK10115 423368005894 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 423368005895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 423368005896 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 423368005897 putative metal binding site [ion binding]; other site 423368005898 hypothetical protein; Provisional; Region: PRK13680 423368005899 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 423368005900 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 423368005901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 423368005902 ATP-grasp domain; Region: ATP-grasp; pfam02222 423368005903 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 423368005904 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 423368005905 active site 423368005906 intersubunit interface [polypeptide binding]; other site 423368005907 catalytic residue [active] 423368005908 phosphogluconate dehydratase; Validated; Region: PRK09054 423368005909 6-phosphogluconate dehydratase; Region: edd; TIGR01196 423368005910 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 423368005911 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 423368005912 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 423368005913 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 423368005914 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 423368005915 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 423368005916 putative active site [active] 423368005917 pyruvate kinase; Provisional; Region: PRK05826 423368005918 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 423368005919 domain interfaces; other site 423368005920 active site 423368005921 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 423368005922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 423368005923 putative acyl-acceptor binding pocket; other site 423368005924 putative peptidase; Provisional; Region: PRK11649 423368005925 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 423368005926 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368005927 Peptidase family M23; Region: Peptidase_M23; pfam01551 423368005928 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 423368005929 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 423368005930 metal binding site [ion binding]; metal-binding site 423368005931 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 423368005932 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 423368005933 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 423368005934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368005935 ABC-ATPase subunit interface; other site 423368005936 dimer interface [polypeptide binding]; other site 423368005937 putative PBP binding regions; other site 423368005938 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 423368005939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368005940 Walker A motif; other site 423368005941 ATP binding site [chemical binding]; other site 423368005942 Walker B motif; other site 423368005943 arginine finger; other site 423368005944 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 423368005945 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 423368005946 RuvA N terminal domain; Region: RuvA_N; pfam01330 423368005947 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 423368005948 hypothetical protein; Provisional; Region: PRK11470 423368005949 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 423368005950 active site 423368005951 putative DNA-binding cleft [nucleotide binding]; other site 423368005952 dimer interface [polypeptide binding]; other site 423368005953 hypothetical protein; Validated; Region: PRK00110 423368005954 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 423368005955 nudix motif; other site 423368005956 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 423368005957 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 423368005958 dimer interface [polypeptide binding]; other site 423368005959 anticodon binding site; other site 423368005960 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 423368005961 homodimer interface [polypeptide binding]; other site 423368005962 motif 1; other site 423368005963 active site 423368005964 motif 2; other site 423368005965 GAD domain; Region: GAD; pfam02938 423368005966 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 423368005967 active site 423368005968 motif 3; other site 423368005969 Isochorismatase family; Region: Isochorismatase; pfam00857 423368005970 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 423368005971 catalytic triad [active] 423368005972 conserved cis-peptide bond; other site 423368005973 hypothetical protein; Provisional; Region: PRK10302 423368005974 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 423368005975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368005976 S-adenosylmethionine binding site [chemical binding]; other site 423368005977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368005978 S-adenosylmethionine binding site [chemical binding]; other site 423368005979 copper homeostasis protein CutC; Provisional; Region: PRK11572 423368005980 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 423368005981 putative metal binding site [ion binding]; other site 423368005982 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 423368005983 arginyl-tRNA synthetase; Region: argS; TIGR00456 423368005984 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 423368005985 active site 423368005986 HIGH motif; other site 423368005987 KMSK motif region; other site 423368005988 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 423368005989 tRNA binding surface [nucleotide binding]; other site 423368005990 anticodon binding site; other site 423368005991 penicillin-binding protein 2; Provisional; Region: PRK10795 423368005992 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 423368005993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 423368005994 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 423368005995 Flagellar protein FlhE; Region: FlhE; pfam06366 423368005996 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 423368005997 FHIPEP family; Region: FHIPEP; pfam00771 423368005998 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 423368005999 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 423368006000 chemotaxis regulator CheZ; Provisional; Region: PRK11166 423368006001 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 423368006002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368006003 active site 423368006004 phosphorylation site [posttranslational modification] 423368006005 intermolecular recognition site; other site 423368006006 dimerization interface [polypeptide binding]; other site 423368006007 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 423368006008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368006009 active site 423368006010 phosphorylation site [posttranslational modification] 423368006011 intermolecular recognition site; other site 423368006012 dimerization interface [polypeptide binding]; other site 423368006013 CheB methylesterase; Region: CheB_methylest; pfam01339 423368006014 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 423368006015 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 423368006016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368006017 S-adenosylmethionine binding site [chemical binding]; other site 423368006018 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 423368006019 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 423368006020 dimer interface [polypeptide binding]; other site 423368006021 ligand binding site [chemical binding]; other site 423368006022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368006023 dimerization interface [polypeptide binding]; other site 423368006024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368006025 dimer interface [polypeptide binding]; other site 423368006026 putative CheW interface [polypeptide binding]; other site 423368006027 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 423368006028 putative CheA interaction surface; other site 423368006029 chemotaxis protein CheA; Provisional; Region: PRK10547 423368006030 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 423368006031 putative binding surface; other site 423368006032 active site 423368006033 CheY binding; Region: CheY-binding; pfam09078 423368006034 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 423368006035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368006036 ATP binding site [chemical binding]; other site 423368006037 Mg2+ binding site [ion binding]; other site 423368006038 G-X-G motif; other site 423368006039 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 423368006040 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 423368006041 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 423368006042 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 423368006043 ligand binding site [chemical binding]; other site 423368006044 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 423368006045 flagellar motor protein MotA; Validated; Region: PRK09110 423368006046 transcriptional activator FlhC; Provisional; Region: PRK12722 423368006047 transcriptional activator FlhD; Provisional; Region: PRK02909 423368006048 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 423368006049 Ligand Binding Site [chemical binding]; other site 423368006050 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 423368006051 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 423368006052 active site 423368006053 homotetramer interface [polypeptide binding]; other site 423368006054 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 423368006055 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 423368006056 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 423368006057 DJ-1 family protein; Region: not_thiJ; TIGR01383 423368006058 conserved cys residue [active] 423368006059 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 423368006060 Ferritin-like domain; Region: Ferritin; pfam00210 423368006061 ferroxidase diiron center [ion binding]; other site 423368006062 hypothetical protein; Provisional; Region: PRK09273 423368006063 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 423368006064 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 423368006065 YecR-like lipoprotein; Region: YecR; pfam13992 423368006066 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 423368006067 Ferritin-like domain; Region: Ferritin; pfam00210 423368006068 ferroxidase diiron center [ion binding]; other site 423368006069 probable metal-binding protein; Region: matur_matur; TIGR03853 423368006070 tyrosine transporter TyrP; Provisional; Region: PRK15132 423368006071 aromatic amino acid transport protein; Region: araaP; TIGR00837 423368006072 hypothetical protein; Provisional; Region: PRK10396 423368006073 yecA family protein; Region: ygfB_yecA; TIGR02292 423368006074 SEC-C motif; Region: SEC-C; pfam02810 423368006075 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 423368006076 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 423368006077 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 423368006078 NlpC/P60 family; Region: NLPC_P60; cl17555 423368006079 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 423368006080 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 423368006081 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 423368006082 GIY-YIG motif/motif A; other site 423368006083 active site 423368006084 catalytic site [active] 423368006085 putative DNA binding site [nucleotide binding]; other site 423368006086 metal binding site [ion binding]; metal-binding site 423368006087 UvrB/uvrC motif; Region: UVR; pfam02151 423368006088 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 423368006089 Helix-hairpin-helix motif; Region: HHH; pfam00633 423368006090 response regulator; Provisional; Region: PRK09483 423368006091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368006092 active site 423368006093 phosphorylation site [posttranslational modification] 423368006094 intermolecular recognition site; other site 423368006095 dimerization interface [polypeptide binding]; other site 423368006096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368006097 DNA binding residues [nucleotide binding] 423368006098 dimerization interface [polypeptide binding]; other site 423368006099 hypothetical protein; Provisional; Region: PRK10613 423368006100 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 423368006101 Autoinducer binding domain; Region: Autoind_bind; pfam03472 423368006102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368006103 DNA binding residues [nucleotide binding] 423368006104 dimerization interface [polypeptide binding]; other site 423368006105 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 423368006106 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 423368006107 Walker A/P-loop; other site 423368006108 ATP binding site [chemical binding]; other site 423368006109 Q-loop/lid; other site 423368006110 ABC transporter signature motif; other site 423368006111 Walker B; other site 423368006112 D-loop; other site 423368006113 H-loop/switch region; other site 423368006114 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 423368006115 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368006117 dimer interface [polypeptide binding]; other site 423368006118 conserved gate region; other site 423368006119 putative PBP binding loops; other site 423368006120 ABC-ATPase subunit interface; other site 423368006121 D-cysteine desulfhydrase; Validated; Region: PRK03910 423368006122 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 423368006123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368006124 catalytic residue [active] 423368006125 cystine transporter subunit; Provisional; Region: PRK11260 423368006126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368006127 substrate binding pocket [chemical binding]; other site 423368006128 membrane-bound complex binding site; other site 423368006129 hinge residues; other site 423368006130 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 423368006131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 423368006132 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 423368006133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 423368006134 DNA binding residues [nucleotide binding] 423368006135 flagellin; Validated; Region: PRK08026 423368006136 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 423368006137 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 423368006138 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 423368006139 flagellar capping protein; Reviewed; Region: fliD; PRK08032 423368006140 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 423368006141 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 423368006142 flagellar protein FliS; Validated; Region: fliS; PRK05685 423368006143 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 423368006144 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 423368006145 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 423368006146 active site 423368006147 Na/Ca binding site [ion binding]; other site 423368006148 catalytic site [active] 423368006149 lipoprotein; Provisional; Region: PRK10397 423368006150 putative inner membrane protein; Provisional; Region: PRK11099 423368006151 Sulphur transport; Region: Sulf_transp; pfam04143 423368006152 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 423368006153 CPxP motif; other site 423368006154 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 423368006155 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 423368006156 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 423368006157 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 423368006158 flagellar motor switch protein FliG; Region: fliG; TIGR00207 423368006159 FliG C-terminal domain; Region: FliG_C; pfam01706 423368006160 flagellar assembly protein H; Validated; Region: fliH; PRK05687 423368006161 Flagellar assembly protein FliH; Region: FliH; pfam02108 423368006162 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 423368006163 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 423368006164 Walker A motif/ATP binding site; other site 423368006165 Walker B motif; other site 423368006166 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 423368006167 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 423368006168 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 423368006169 flagellar hook-length control protein; Provisional; Region: PRK10118 423368006170 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 423368006171 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 423368006172 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 423368006173 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 423368006174 flagellar motor switch protein; Validated; Region: fliN; PRK05698 423368006175 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 423368006176 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 423368006177 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 423368006178 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 423368006179 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 423368006180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368006181 DNA binding residues [nucleotide binding] 423368006182 dimerization interface [polypeptide binding]; other site 423368006183 hypothetical protein; Provisional; Region: PRK10708 423368006184 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 423368006185 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 423368006186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368006187 active site 423368006188 motif I; other site 423368006189 motif II; other site 423368006190 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 423368006191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368006192 metal binding site [ion binding]; metal-binding site 423368006193 active site 423368006194 I-site; other site 423368006195 Uncharacterized small protein [Function unknown]; Region: COG5475 423368006196 hypothetical protein; Provisional; Region: PRK10062 423368006197 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 423368006198 EamA-like transporter family; Region: EamA; pfam00892 423368006199 EamA-like transporter family; Region: EamA; pfam00892 423368006200 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 423368006201 additional DNA contacts [nucleotide binding]; other site 423368006202 mismatch recognition site; other site 423368006203 active site 423368006204 zinc binding site [ion binding]; other site 423368006205 DNA intercalation site [nucleotide binding]; other site 423368006206 DNA cytosine methylase; Provisional; Region: PRK10458 423368006207 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 423368006208 cofactor binding site; other site 423368006209 DNA binding site [nucleotide binding] 423368006210 substrate interaction site [chemical binding]; other site 423368006211 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 423368006212 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 423368006213 Zn2+ binding site [ion binding]; other site 423368006214 Mg2+ binding site [ion binding]; other site 423368006215 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368006216 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368006217 trimer interface [polypeptide binding]; other site 423368006218 eyelet of channel; other site 423368006219 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 423368006220 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 423368006221 active site 423368006222 DNA binding site [nucleotide binding] 423368006223 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 423368006224 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 423368006225 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 423368006226 Catalytic site [active] 423368006227 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 423368006228 putative protease; Region: PHA00666 423368006229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 423368006230 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368006231 Sel1 repeat; Region: Sel1; pfam08238 423368006232 Sel1-like repeats; Region: SEL1; smart00671 423368006233 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 423368006234 AMP nucleosidase; Provisional; Region: PRK08292 423368006235 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 423368006236 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 423368006237 MATE family multidrug exporter; Provisional; Region: PRK10189 423368006238 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 423368006239 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 423368006240 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368006241 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 423368006242 Sodium Bile acid symporter family; Region: SBF; cl17470 423368006243 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 423368006244 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 423368006245 P loop; other site 423368006246 Nucleotide binding site [chemical binding]; other site 423368006247 DTAP/Switch II; other site 423368006248 Switch I; other site 423368006249 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 423368006250 P loop; other site 423368006251 Nucleotide binding site [chemical binding]; other site 423368006252 DTAP/Switch II; other site 423368006253 Switch I; other site 423368006254 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 423368006255 Low molecular weight phosphatase family; Region: LMWPc; cd00115 423368006256 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 423368006257 active site 423368006258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368006259 dimerization interface [polypeptide binding]; other site 423368006260 putative DNA binding site [nucleotide binding]; other site 423368006261 putative Zn2+ binding site [ion binding]; other site 423368006262 L,D-transpeptidase; Provisional; Region: PRK10190 423368006263 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 423368006264 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 423368006265 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 423368006266 putative dimer interface [polypeptide binding]; other site 423368006267 active site pocket [active] 423368006268 putative cataytic base [active] 423368006269 cobalamin synthase; Reviewed; Region: cobS; PRK00235 423368006270 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 423368006271 homotrimer interface [polypeptide binding]; other site 423368006272 Walker A motif; other site 423368006273 GTP binding site [chemical binding]; other site 423368006274 Walker B motif; other site 423368006275 cobyric acid synthase; Provisional; Region: PRK00784 423368006276 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 423368006277 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 423368006278 catalytic triad [active] 423368006279 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 423368006280 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 423368006281 Walker A/P-loop; other site 423368006282 ATP binding site [chemical binding]; other site 423368006283 Q-loop/lid; other site 423368006284 ABC transporter signature motif; other site 423368006285 Walker B; other site 423368006286 D-loop; other site 423368006287 H-loop/switch region; other site 423368006288 cobalt transport protein CbiQ; Provisional; Region: PRK15485 423368006289 cobalt transport protein CbiN; Provisional; Region: PRK02898 423368006290 cobalt transport protein CbiM; Validated; Region: PRK08319 423368006291 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 423368006292 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 423368006293 active site 423368006294 SAM binding site [chemical binding]; other site 423368006295 homodimer interface [polypeptide binding]; other site 423368006296 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 423368006297 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 423368006298 active site 423368006299 C-terminal domain interface [polypeptide binding]; other site 423368006300 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 423368006301 active site 423368006302 N-terminal domain interface [polypeptide binding]; other site 423368006303 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 423368006304 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 423368006305 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 423368006306 active site 423368006307 SAM binding site [chemical binding]; other site 423368006308 homodimer interface [polypeptide binding]; other site 423368006309 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 423368006310 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 423368006311 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 423368006312 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 423368006313 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 423368006314 active site 423368006315 SAM binding site [chemical binding]; other site 423368006316 homodimer interface [polypeptide binding]; other site 423368006317 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 423368006318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368006319 S-adenosylmethionine binding site [chemical binding]; other site 423368006320 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 423368006321 active site 423368006322 putative homodimer interface [polypeptide binding]; other site 423368006323 SAM binding site [chemical binding]; other site 423368006324 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 423368006325 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 423368006326 Precorrin-8X methylmutase; Region: CbiC; pfam02570 423368006327 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 423368006328 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 423368006329 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 423368006330 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 423368006331 catalytic triad [active] 423368006332 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 423368006333 Sensory domain found in PocR; Region: PocR; pfam10114 423368006334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368006335 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368006336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368006337 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 423368006338 amphipathic channel; other site 423368006339 Asn-Pro-Ala signature motifs; other site 423368006340 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 423368006341 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 423368006342 Hexamer interface [polypeptide binding]; other site 423368006343 Putative hexagonal pore residue; other site 423368006344 propanediol utilization protein PduB; Provisional; Region: PRK15415 423368006345 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 423368006346 putative hexamer interface [polypeptide binding]; other site 423368006347 putative hexagonal pore; other site 423368006348 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 423368006349 putative hexamer interface [polypeptide binding]; other site 423368006350 putative hexagonal pore; other site 423368006351 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 423368006352 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 423368006353 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 423368006354 alpha-beta subunit interface [polypeptide binding]; other site 423368006355 alpha-gamma subunit interface [polypeptide binding]; other site 423368006356 active site 423368006357 substrate and K+ binding site; other site 423368006358 K+ binding site [ion binding]; other site 423368006359 cobalamin binding site [chemical binding]; other site 423368006360 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 423368006361 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 423368006362 Cell division protein FtsA; Region: FtsA; cl17206 423368006363 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 423368006364 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 423368006365 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 423368006366 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 423368006367 Hexamer interface [polypeptide binding]; other site 423368006368 Putative hexagonal pore residue; other site 423368006369 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 423368006370 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 423368006371 putative hexamer interface [polypeptide binding]; other site 423368006372 putative hexagonal pore; other site 423368006373 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 423368006374 Propanediol utilisation protein PduL; Region: PduL; pfam06130 423368006375 Propanediol utilisation protein PduL; Region: PduL; pfam06130 423368006376 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 423368006377 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 423368006378 Hexamer/Pentamer interface [polypeptide binding]; other site 423368006379 central pore; other site 423368006380 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 423368006381 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 423368006382 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 423368006383 putative catalytic cysteine [active] 423368006384 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 423368006385 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 423368006386 putative active site [active] 423368006387 metal binding site [ion binding]; metal-binding site 423368006388 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 423368006389 SLBB domain; Region: SLBB; pfam10531 423368006390 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 423368006391 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 423368006392 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 423368006393 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 423368006394 putative hexamer interface [polypeptide binding]; other site 423368006395 putative hexagonal pore; other site 423368006396 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 423368006397 putative hexamer interface [polypeptide binding]; other site 423368006398 putative hexagonal pore; other site 423368006399 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 423368006400 putative hexamer interface [polypeptide binding]; other site 423368006401 putative hexagonal pore; other site 423368006402 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 423368006403 G3 box; other site 423368006404 Switch II region; other site 423368006405 GTP/Mg2+ binding site [chemical binding]; other site 423368006406 G4 box; other site 423368006407 G5 box; other site 423368006408 propionate kinase; Reviewed; Region: PRK12397 423368006409 propionate/acetate kinase; Provisional; Region: PRK12379 423368006410 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 423368006411 hypothetical protein; Provisional; Region: PRK05423 423368006412 Predicted membrane protein [Function unknown]; Region: COG1289 423368006413 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 423368006414 DNA gyrase inhibitor; Provisional; Region: PRK10016 423368006415 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 423368006416 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 423368006417 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 423368006418 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 423368006419 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 423368006420 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 423368006421 4Fe-4S binding domain; Region: Fer4; cl02805 423368006422 thiosulfate reductase PhsA; Provisional; Region: PRK15488 423368006423 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 423368006424 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 423368006425 putative [Fe4-S4] binding site [ion binding]; other site 423368006426 putative molybdopterin cofactor binding site [chemical binding]; other site 423368006427 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 423368006428 putative molybdopterin cofactor binding site; other site 423368006429 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 423368006430 SopA-like central domain; Region: SopA; pfam13981 423368006431 SopA-like catalytic domain; Region: SopA_C; pfam13979 423368006432 exonuclease I; Provisional; Region: sbcB; PRK11779 423368006433 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 423368006434 active site 423368006435 catalytic site [active] 423368006436 substrate binding site [chemical binding]; other site 423368006437 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 423368006438 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 423368006439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368006440 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 423368006441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368006442 dimerization interface [polypeptide binding]; other site 423368006443 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 423368006444 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 423368006445 putative NAD(P) binding site [chemical binding]; other site 423368006446 Histidine operon leader 423368006447 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 423368006448 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 423368006449 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 423368006450 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 423368006451 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 423368006452 NAD binding site [chemical binding]; other site 423368006453 dimerization interface [polypeptide binding]; other site 423368006454 product binding site; other site 423368006455 substrate binding site [chemical binding]; other site 423368006456 zinc binding site [ion binding]; other site 423368006457 catalytic residues [active] 423368006458 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 423368006459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368006460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368006461 homodimer interface [polypeptide binding]; other site 423368006462 catalytic residue [active] 423368006463 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 423368006464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368006465 active site 423368006466 motif I; other site 423368006467 motif II; other site 423368006468 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 423368006469 putative active site pocket [active] 423368006470 4-fold oligomerization interface [polypeptide binding]; other site 423368006471 metal binding residues [ion binding]; metal-binding site 423368006472 3-fold/trimer interface [polypeptide binding]; other site 423368006473 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 423368006474 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 423368006475 putative active site [active] 423368006476 oxyanion strand; other site 423368006477 catalytic triad [active] 423368006478 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 423368006479 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 423368006480 catalytic residues [active] 423368006481 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 423368006482 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 423368006483 substrate binding site [chemical binding]; other site 423368006484 glutamase interaction surface [polypeptide binding]; other site 423368006485 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 423368006486 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 423368006487 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 423368006488 metal binding site [ion binding]; metal-binding site 423368006489 chain length determinant protein WzzB; Provisional; Region: PRK15471 423368006490 Chain length determinant protein; Region: Wzz; cl15801 423368006491 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 423368006492 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 423368006493 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 423368006494 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 423368006495 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 423368006496 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 423368006497 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 423368006498 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 423368006499 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 423368006500 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 423368006501 Bacterial sugar transferase; Region: Bac_transf; pfam02397 423368006502 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 423368006503 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 423368006504 active site 423368006505 substrate binding site [chemical binding]; other site 423368006506 metal binding site [ion binding]; metal-binding site 423368006507 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 423368006508 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 423368006509 Substrate binding site; other site 423368006510 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 423368006511 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 423368006512 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 423368006513 putative ADP-binding pocket [chemical binding]; other site 423368006514 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 423368006515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 423368006516 O-Antigen ligase; Region: Wzy_C; pfam04932 423368006517 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 423368006518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 423368006519 active site 423368006520 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 423368006521 trimer interface [polypeptide binding]; other site 423368006522 active site 423368006523 substrate binding site [chemical binding]; other site 423368006524 CoA binding site [chemical binding]; other site 423368006525 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 423368006526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 423368006527 active site 423368006528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 423368006529 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 423368006530 NAD(P) binding site [chemical binding]; other site 423368006531 active site 423368006532 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 423368006533 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 423368006534 inhibitor-cofactor binding pocket; inhibition site 423368006535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368006536 catalytic residue [active] 423368006537 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 423368006538 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 423368006539 NAD binding site [chemical binding]; other site 423368006540 homotetramer interface [polypeptide binding]; other site 423368006541 homodimer interface [polypeptide binding]; other site 423368006542 substrate binding site [chemical binding]; other site 423368006543 active site 423368006544 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 423368006545 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 423368006546 substrate binding site; other site 423368006547 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 423368006548 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 423368006549 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 423368006550 substrate binding site; other site 423368006551 tetramer interface; other site 423368006552 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 423368006553 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 423368006554 NADP binding site [chemical binding]; other site 423368006555 active site 423368006556 putative substrate binding site [chemical binding]; other site 423368006557 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 423368006558 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 423368006559 NAD binding site [chemical binding]; other site 423368006560 substrate binding site [chemical binding]; other site 423368006561 homodimer interface [polypeptide binding]; other site 423368006562 active site 423368006563 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 423368006564 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 423368006565 active site 423368006566 tetramer interface; other site 423368006567 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 423368006568 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 423368006569 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 423368006570 putative ADP-binding pocket [chemical binding]; other site 423368006571 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 423368006572 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 423368006573 colanic acid exporter; Provisional; Region: PRK10459 423368006574 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 423368006575 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 423368006576 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 423368006577 phosphomannomutase CpsG; Provisional; Region: PRK15414 423368006578 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 423368006579 active site 423368006580 substrate binding site [chemical binding]; other site 423368006581 metal binding site [ion binding]; metal-binding site 423368006582 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 423368006583 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 423368006584 Substrate binding site; other site 423368006585 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 423368006586 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 423368006587 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 423368006588 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 423368006589 active site 423368006590 GDP-Mannose binding site [chemical binding]; other site 423368006591 dimer interface [polypeptide binding]; other site 423368006592 modified nudix motif 423368006593 metal binding site [ion binding]; metal-binding site 423368006594 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 423368006595 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 423368006596 NADP binding site [chemical binding]; other site 423368006597 active site 423368006598 putative substrate binding site [chemical binding]; other site 423368006599 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 423368006600 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 423368006601 NADP-binding site; other site 423368006602 homotetramer interface [polypeptide binding]; other site 423368006603 substrate binding site [chemical binding]; other site 423368006604 homodimer interface [polypeptide binding]; other site 423368006605 active site 423368006606 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 423368006607 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 423368006608 putative trimer interface [polypeptide binding]; other site 423368006609 putative active site [active] 423368006610 putative substrate binding site [chemical binding]; other site 423368006611 putative CoA binding site [chemical binding]; other site 423368006612 putative glycosyl transferase; Provisional; Region: PRK10063 423368006613 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 423368006614 metal-binding site 423368006615 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 423368006616 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 423368006617 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 423368006618 putative acyl transferase; Provisional; Region: PRK10191 423368006619 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 423368006620 trimer interface [polypeptide binding]; other site 423368006621 active site 423368006622 substrate binding site [chemical binding]; other site 423368006623 CoA binding site [chemical binding]; other site 423368006624 putative glycosyl transferase; Provisional; Region: PRK10018 423368006625 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 423368006626 active site 423368006627 tyrosine kinase; Provisional; Region: PRK11519 423368006628 Chain length determinant protein; Region: Wzz; pfam02706 423368006629 Chain length determinant protein; Region: Wzz; cl15801 423368006630 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 423368006631 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 423368006632 Low molecular weight phosphatase family; Region: LMWPc; cd00115 423368006633 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 423368006634 active site 423368006635 polysaccharide export protein Wza; Provisional; Region: PRK15078 423368006636 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 423368006637 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 423368006638 FOG: CBS domain [General function prediction only]; Region: COG0517 423368006639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 423368006640 Transporter associated domain; Region: CorC_HlyC; smart01091 423368006641 putative assembly protein; Provisional; Region: PRK10833 423368006642 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 423368006643 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 423368006644 trimer interface [polypeptide binding]; other site 423368006645 active site 423368006646 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 423368006647 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 423368006648 ATP-binding site [chemical binding]; other site 423368006649 Sugar specificity; other site 423368006650 Pyrimidine base specificity; other site 423368006651 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 423368006652 PAS domain S-box; Region: sensory_box; TIGR00229 423368006653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368006654 putative active site [active] 423368006655 heme pocket [chemical binding]; other site 423368006656 PAS domain S-box; Region: sensory_box; TIGR00229 423368006657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368006658 putative active site [active] 423368006659 heme pocket [chemical binding]; other site 423368006660 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 423368006661 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368006662 metal binding site [ion binding]; metal-binding site 423368006663 active site 423368006664 I-site; other site 423368006665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368006666 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 423368006667 AlkA N-terminal domain; Region: AlkA_N; pfam06029 423368006668 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 423368006669 minor groove reading motif; other site 423368006670 helix-hairpin-helix signature motif; other site 423368006671 substrate binding pocket [chemical binding]; other site 423368006672 active site 423368006673 putative chaperone; Provisional; Region: PRK11678 423368006674 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 423368006675 nucleotide binding site [chemical binding]; other site 423368006676 putative NEF/HSP70 interaction site [polypeptide binding]; other site 423368006677 SBD interface [polypeptide binding]; other site 423368006678 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 423368006679 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368006680 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368006681 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 423368006682 Protein export membrane protein; Region: SecD_SecF; cl14618 423368006683 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 423368006684 putative transporter; Provisional; Region: PRK10504 423368006685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368006686 putative substrate translocation pore; other site 423368006687 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 423368006688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368006689 dimerization interface [polypeptide binding]; other site 423368006690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368006691 dimer interface [polypeptide binding]; other site 423368006692 phosphorylation site [posttranslational modification] 423368006693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368006694 ATP binding site [chemical binding]; other site 423368006695 Mg2+ binding site [ion binding]; other site 423368006696 G-X-G motif; other site 423368006697 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 423368006698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368006699 active site 423368006700 phosphorylation site [posttranslational modification] 423368006701 intermolecular recognition site; other site 423368006702 dimerization interface [polypeptide binding]; other site 423368006703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368006704 DNA binding site [nucleotide binding] 423368006705 PcfJ-like protein; Region: PcfJ; pfam14284 423368006706 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 423368006707 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 423368006708 putative protease; Provisional; Region: PRK15452 423368006709 Peptidase family U32; Region: Peptidase_U32; pfam01136 423368006710 type III secretion system protein; Provisional; Region: PRK15383 423368006711 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 423368006712 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 423368006713 lipid kinase; Reviewed; Region: PRK13054 423368006714 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 423368006715 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 423368006716 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 423368006717 putative active site; other site 423368006718 catalytic residue [active] 423368006719 nucleoside transporter; Region: 2A0110; TIGR00889 423368006720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368006721 putative substrate translocation pore; other site 423368006722 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 423368006723 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368006724 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 423368006725 substrate binding site [chemical binding]; other site 423368006726 ATP binding site [chemical binding]; other site 423368006727 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 423368006728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368006729 DNA-binding site [nucleotide binding]; DNA binding site 423368006730 UTRA domain; Region: UTRA; pfam07702 423368006731 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 423368006732 dimer interface [polypeptide binding]; other site 423368006733 substrate binding site [chemical binding]; other site 423368006734 ATP binding site [chemical binding]; other site 423368006735 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 423368006736 substrate binding site [chemical binding]; other site 423368006737 multimerization interface [polypeptide binding]; other site 423368006738 ATP binding site [chemical binding]; other site 423368006739 Predicted integral membrane protein [Function unknown]; Region: COG5455 423368006740 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 423368006741 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 423368006742 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 423368006743 PapC N-terminal domain; Region: PapC_N; pfam13954 423368006744 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368006745 PapC C-terminal domain; Region: PapC_C; pfam13953 423368006746 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 423368006747 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368006748 fimbrial chaperone protein; Provisional; Region: PRK15220 423368006749 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 423368006750 antiporter inner membrane protein; Provisional; Region: PRK11670 423368006751 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 423368006752 Walker A motif; other site 423368006753 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 423368006754 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 423368006755 active site 423368006756 HIGH motif; other site 423368006757 KMSKS motif; other site 423368006758 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 423368006759 tRNA binding surface [nucleotide binding]; other site 423368006760 anticodon binding site; other site 423368006761 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 423368006762 dimer interface [polypeptide binding]; other site 423368006763 putative tRNA-binding site [nucleotide binding]; other site 423368006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 423368006765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 423368006766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 423368006767 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 423368006768 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 423368006769 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 423368006770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368006771 active site 423368006772 phosphorylation site [posttranslational modification] 423368006773 intermolecular recognition site; other site 423368006774 dimerization interface [polypeptide binding]; other site 423368006775 LytTr DNA-binding domain; Region: LytTR; pfam04397 423368006776 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 423368006777 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 423368006778 GAF domain; Region: GAF; pfam01590 423368006779 Histidine kinase; Region: His_kinase; pfam06580 423368006780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368006781 ATP binding site [chemical binding]; other site 423368006782 Mg2+ binding site [ion binding]; other site 423368006783 G-X-G motif; other site 423368006784 transcriptional regulator MirA; Provisional; Region: PRK15043 423368006785 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 423368006786 DNA binding residues [nucleotide binding] 423368006787 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 423368006788 putative PBP binding loops; other site 423368006789 ABC-ATPase subunit interface; other site 423368006790 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 423368006791 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 423368006792 Walker A/P-loop; other site 423368006793 ATP binding site [chemical binding]; other site 423368006794 Q-loop/lid; other site 423368006795 ABC transporter signature motif; other site 423368006796 Walker B; other site 423368006797 D-loop; other site 423368006798 H-loop/switch region; other site 423368006799 CBS domain; Region: CBS; pfam00571 423368006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368006801 dimer interface [polypeptide binding]; other site 423368006802 conserved gate region; other site 423368006803 ABC-ATPase subunit interface; other site 423368006804 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 423368006805 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 423368006806 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 423368006807 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 423368006808 D-lactate dehydrogenase; Provisional; Region: PRK11183 423368006809 FAD binding domain; Region: FAD_binding_4; pfam01565 423368006810 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 423368006811 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 423368006812 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 423368006813 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 423368006814 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 423368006815 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 423368006816 oxidoreductase; Provisional; Region: PRK12743 423368006817 classical (c) SDRs; Region: SDR_c; cd05233 423368006818 NAD(P) binding site [chemical binding]; other site 423368006819 active site 423368006820 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 423368006821 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 423368006822 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 423368006823 FMN binding site [chemical binding]; other site 423368006824 active site 423368006825 catalytic residues [active] 423368006826 substrate binding site [chemical binding]; other site 423368006827 salicylate hydroxylase; Provisional; Region: PRK08163 423368006828 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 423368006829 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 423368006830 maleylacetoacetate isomerase; Region: maiA; TIGR01262 423368006831 C-terminal domain interface [polypeptide binding]; other site 423368006832 GSH binding site (G-site) [chemical binding]; other site 423368006833 putative dimer interface [polypeptide binding]; other site 423368006834 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 423368006835 dimer interface [polypeptide binding]; other site 423368006836 N-terminal domain interface [polypeptide binding]; other site 423368006837 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 423368006838 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 423368006839 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 423368006840 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 423368006841 Cupin domain; Region: Cupin_2; pfam07883 423368006842 Cupin domain; Region: Cupin_2; pfam07883 423368006843 benzoate transport; Region: 2A0115; TIGR00895 423368006844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368006845 putative substrate translocation pore; other site 423368006846 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 423368006847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368006848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368006849 dimerization interface [polypeptide binding]; other site 423368006850 hypothetical protein; Provisional; Region: PRK01821 423368006851 hypothetical protein; Provisional; Region: PRK10711 423368006852 cytidine deaminase; Provisional; Region: PRK09027 423368006853 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 423368006854 active site 423368006855 catalytic motif [active] 423368006856 Zn binding site [ion binding]; other site 423368006857 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 423368006858 active site 423368006859 catalytic motif [active] 423368006860 Zn binding site [ion binding]; other site 423368006861 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 423368006862 putative active site [active] 423368006863 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 423368006864 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 423368006865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 423368006866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368006867 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 423368006868 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 423368006869 homodimer interface [polypeptide binding]; other site 423368006870 active site 423368006871 FMN binding site [chemical binding]; other site 423368006872 substrate binding site [chemical binding]; other site 423368006873 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 423368006874 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 423368006875 TM-ABC transporter signature motif; other site 423368006876 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 423368006877 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 423368006878 Walker A/P-loop; other site 423368006879 ATP binding site [chemical binding]; other site 423368006880 Q-loop/lid; other site 423368006881 ABC transporter signature motif; other site 423368006882 Walker B; other site 423368006883 D-loop; other site 423368006884 H-loop/switch region; other site 423368006885 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 423368006886 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 423368006887 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 423368006888 ligand binding site [chemical binding]; other site 423368006889 calcium binding site [ion binding]; other site 423368006890 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 423368006891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368006892 DNA binding site [nucleotide binding] 423368006893 domain linker motif; other site 423368006894 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 423368006895 dimerization interface (closed form) [polypeptide binding]; other site 423368006896 ligand binding site [chemical binding]; other site 423368006897 Predicted membrane protein [Function unknown]; Region: COG2311 423368006898 hypothetical protein; Provisional; Region: PRK10835 423368006899 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 423368006900 GTP cyclohydrolase I; Provisional; Region: PLN03044 423368006901 active site 423368006902 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 423368006903 S-formylglutathione hydrolase; Region: PLN02442 423368006904 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 423368006905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368006906 non-specific DNA binding site [nucleotide binding]; other site 423368006907 salt bridge; other site 423368006908 sequence-specific DNA binding site [nucleotide binding]; other site 423368006909 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 423368006910 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 423368006911 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 423368006912 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 423368006913 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 423368006914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368006915 motif II; other site 423368006916 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 423368006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368006918 putative substrate translocation pore; other site 423368006919 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 423368006920 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368006921 N-terminal plug; other site 423368006922 ligand-binding site [chemical binding]; other site 423368006923 lysine transporter; Provisional; Region: PRK10836 423368006924 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 423368006925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368006926 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 423368006927 putative dimerization interface [polypeptide binding]; other site 423368006928 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 423368006929 endonuclease IV; Provisional; Region: PRK01060 423368006930 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 423368006931 AP (apurinic/apyrimidinic) site pocket; other site 423368006932 DNA interaction; other site 423368006933 Metal-binding active site; metal-binding site 423368006934 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 423368006935 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 423368006936 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 423368006937 active site 423368006938 P-loop; other site 423368006939 phosphorylation site [posttranslational modification] 423368006940 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 423368006941 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 423368006942 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 423368006943 putative substrate binding site [chemical binding]; other site 423368006944 putative ATP binding site [chemical binding]; other site 423368006945 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 423368006946 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368006947 active site 423368006948 phosphorylation site [posttranslational modification] 423368006949 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 423368006950 dimerization domain swap beta strand [polypeptide binding]; other site 423368006951 regulatory protein interface [polypeptide binding]; other site 423368006952 active site 423368006953 regulatory phosphorylation site [posttranslational modification]; other site 423368006954 sugar efflux transporter B; Provisional; Region: PRK15011 423368006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368006956 putative substrate translocation pore; other site 423368006957 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 423368006958 Flagellin N-methylase; Region: FliB; cl00497 423368006959 elongation factor P; Provisional; Region: PRK04542 423368006960 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 423368006961 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 423368006962 RNA binding site [nucleotide binding]; other site 423368006963 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 423368006964 RNA binding site [nucleotide binding]; other site 423368006965 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 423368006966 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 423368006967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 423368006968 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 423368006969 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 423368006970 active site 423368006971 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 423368006972 NlpC/P60 family; Region: NLPC_P60; pfam00877 423368006973 phage resistance protein; Provisional; Region: PRK10551 423368006974 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 423368006975 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368006976 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 423368006977 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 423368006978 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 423368006979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368006980 dimer interface [polypeptide binding]; other site 423368006981 conserved gate region; other site 423368006982 putative PBP binding loops; other site 423368006983 ABC-ATPase subunit interface; other site 423368006984 microcin C ABC transporter permease; Provisional; Region: PRK15021 423368006985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368006986 dimer interface [polypeptide binding]; other site 423368006987 conserved gate region; other site 423368006988 ABC-ATPase subunit interface; other site 423368006989 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 423368006990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368006991 Walker A/P-loop; other site 423368006992 ATP binding site [chemical binding]; other site 423368006993 Q-loop/lid; other site 423368006994 ABC transporter signature motif; other site 423368006995 Walker B; other site 423368006996 D-loop; other site 423368006997 H-loop/switch region; other site 423368006998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 423368006999 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368007000 Walker A/P-loop; other site 423368007001 ATP binding site [chemical binding]; other site 423368007002 Q-loop/lid; other site 423368007003 ABC transporter signature motif; other site 423368007004 Walker B; other site 423368007005 D-loop; other site 423368007006 H-loop/switch region; other site 423368007007 hypothetical protein; Provisional; Region: PRK11835 423368007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007009 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 423368007010 putative substrate translocation pore; other site 423368007011 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 423368007012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368007013 RNA binding surface [nucleotide binding]; other site 423368007014 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 423368007015 active site 423368007016 uracil binding [chemical binding]; other site 423368007017 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 423368007018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368007019 ATP binding site [chemical binding]; other site 423368007020 putative Mg++ binding site [ion binding]; other site 423368007021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368007022 nucleotide binding region [chemical binding]; other site 423368007023 ATP-binding site [chemical binding]; other site 423368007024 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 423368007025 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 423368007026 5S rRNA interface [nucleotide binding]; other site 423368007027 CTC domain interface [polypeptide binding]; other site 423368007028 L16 interface [polypeptide binding]; other site 423368007029 Nucleoid-associated protein [General function prediction only]; Region: COG3081 423368007030 nucleoid-associated protein NdpA; Validated; Region: PRK00378 423368007031 hypothetical protein; Provisional; Region: PRK13689 423368007032 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 423368007033 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 423368007034 Sulfatase; Region: Sulfatase; cl17466 423368007035 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 423368007036 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 423368007037 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 423368007038 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 423368007039 Leucine-rich repeats; other site 423368007040 Substrate binding site [chemical binding]; other site 423368007041 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368007042 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 423368007043 transcriptional regulator NarP; Provisional; Region: PRK10403 423368007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368007045 active site 423368007046 phosphorylation site [posttranslational modification] 423368007047 intermolecular recognition site; other site 423368007048 dimerization interface [polypeptide binding]; other site 423368007049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368007050 DNA binding residues [nucleotide binding] 423368007051 dimerization interface [polypeptide binding]; other site 423368007052 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 423368007053 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 423368007054 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 423368007055 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 423368007056 catalytic residues [active] 423368007057 central insert; other site 423368007058 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 423368007059 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 423368007060 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 423368007061 heme exporter protein CcmC; Region: ccmC; TIGR01191 423368007062 heme exporter protein CcmB; Region: ccmB; TIGR01190 423368007063 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 423368007064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368007065 Walker A/P-loop; other site 423368007066 ATP binding site [chemical binding]; other site 423368007067 Q-loop/lid; other site 423368007068 ABC transporter signature motif; other site 423368007069 Walker B; other site 423368007070 D-loop; other site 423368007071 H-loop/switch region; other site 423368007072 cytochrome c-type protein NapC; Provisional; Region: PRK10617 423368007073 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 423368007074 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 423368007075 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 423368007076 4Fe-4S binding domain; Region: Fer4_5; pfam12801 423368007077 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368007078 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 423368007079 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 423368007080 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 423368007081 [4Fe-4S] binding site [ion binding]; other site 423368007082 molybdopterin cofactor binding site; other site 423368007083 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 423368007084 molybdopterin cofactor binding site; other site 423368007085 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 423368007086 ferredoxin-type protein; Provisional; Region: PRK10194 423368007087 4Fe-4S binding domain; Region: Fer4; cl02805 423368007088 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 423368007089 secondary substrate binding site; other site 423368007090 primary substrate binding site; other site 423368007091 inhibition loop; other site 423368007092 dimerization interface [polypeptide binding]; other site 423368007093 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 423368007094 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 423368007095 Walker A/P-loop; other site 423368007096 ATP binding site [chemical binding]; other site 423368007097 Q-loop/lid; other site 423368007098 ABC transporter signature motif; other site 423368007099 Walker B; other site 423368007100 D-loop; other site 423368007101 H-loop/switch region; other site 423368007102 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 423368007103 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 423368007104 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 423368007105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368007106 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 423368007107 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 423368007108 DNA binding site [nucleotide binding] 423368007109 active site 423368007110 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 423368007111 ApbE family; Region: ApbE; pfam02424 423368007112 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 423368007113 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 423368007114 trimer interface [polypeptide binding]; other site 423368007115 eyelet of channel; other site 423368007116 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 423368007117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368007118 ATP binding site [chemical binding]; other site 423368007119 G-X-G motif; other site 423368007120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 423368007121 putative binding surface; other site 423368007122 active site 423368007123 transcriptional regulator RcsB; Provisional; Region: PRK10840 423368007124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368007125 active site 423368007126 phosphorylation site [posttranslational modification] 423368007127 intermolecular recognition site; other site 423368007128 dimerization interface [polypeptide binding]; other site 423368007129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368007130 DNA binding residues [nucleotide binding] 423368007131 dimerization interface [polypeptide binding]; other site 423368007132 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 423368007133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368007134 dimer interface [polypeptide binding]; other site 423368007135 phosphorylation site [posttranslational modification] 423368007136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368007137 ATP binding site [chemical binding]; other site 423368007138 Mg2+ binding site [ion binding]; other site 423368007139 G-X-G motif; other site 423368007140 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 423368007141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368007142 active site 423368007143 phosphorylation site [posttranslational modification] 423368007144 intermolecular recognition site; other site 423368007145 dimerization interface [polypeptide binding]; other site 423368007146 DNA gyrase subunit A; Validated; Region: PRK05560 423368007147 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 423368007148 CAP-like domain; other site 423368007149 active site 423368007150 primary dimer interface [polypeptide binding]; other site 423368007151 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368007152 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368007153 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368007154 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368007155 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368007156 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368007157 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 423368007158 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 423368007159 active site pocket [active] 423368007160 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 423368007161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007162 putative substrate translocation pore; other site 423368007163 Transcriptional regulators [Transcription]; Region: GntR; COG1802 423368007164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368007165 DNA-binding site [nucleotide binding]; DNA binding site 423368007166 FCD domain; Region: FCD; pfam07729 423368007167 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 423368007168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368007169 S-adenosylmethionine binding site [chemical binding]; other site 423368007170 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 423368007171 ATP cone domain; Region: ATP-cone; pfam03477 423368007172 Class I ribonucleotide reductase; Region: RNR_I; cd01679 423368007173 active site 423368007174 dimer interface [polypeptide binding]; other site 423368007175 catalytic residues [active] 423368007176 effector binding site; other site 423368007177 R2 peptide binding site; other site 423368007178 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 423368007179 dimer interface [polypeptide binding]; other site 423368007180 putative radical transfer pathway; other site 423368007181 diiron center [ion binding]; other site 423368007182 tyrosyl radical; other site 423368007183 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 423368007184 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 423368007185 catalytic loop [active] 423368007186 iron binding site [ion binding]; other site 423368007187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368007188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007189 putative substrate translocation pore; other site 423368007190 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 423368007191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368007192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368007193 dimerization interface [polypeptide binding]; other site 423368007194 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 423368007195 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 423368007196 active site 423368007197 catalytic site [active] 423368007198 metal binding site [ion binding]; metal-binding site 423368007199 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 423368007200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007201 putative substrate translocation pore; other site 423368007202 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 423368007203 hydroxyglutarate oxidase; Provisional; Region: PRK11728 423368007204 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 423368007205 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 423368007206 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 423368007207 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 423368007208 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368007209 Cysteine-rich domain; Region: CCG; pfam02754 423368007210 Cysteine-rich domain; Region: CCG; pfam02754 423368007211 deubiquitinase SseL; Provisional; Region: PRK14848 423368007212 hypothetical protein; Provisional; Region: PRK03673 423368007213 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 423368007214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007215 D-galactonate transporter; Region: 2A0114; TIGR00893 423368007216 putative substrate translocation pore; other site 423368007217 L-rhamnonate dehydratase; Provisional; Region: PRK15440 423368007218 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 423368007219 putative active site pocket [active] 423368007220 putative metal binding site [ion binding]; other site 423368007221 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 423368007222 Transcriptional regulator [Transcription]; Region: IclR; COG1414 423368007223 Bacterial transcriptional regulator; Region: IclR; pfam01614 423368007224 hypothetical protein; Provisional; Region: PRK03673 423368007225 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 423368007226 putative MPT binding site; other site 423368007227 Competence-damaged protein; Region: CinA; cl00666 423368007228 YfaZ precursor; Region: YfaZ; pfam07437 423368007229 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 423368007230 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 423368007231 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 423368007232 catalytic core [active] 423368007233 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 423368007234 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 423368007235 inhibitor-cofactor binding pocket; inhibition site 423368007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368007237 catalytic residue [active] 423368007238 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 423368007239 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 423368007240 Ligand binding site; other site 423368007241 Putative Catalytic site; other site 423368007242 DXD motif; other site 423368007243 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 423368007244 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 423368007245 active site 423368007246 substrate binding site [chemical binding]; other site 423368007247 cosubstrate binding site; other site 423368007248 catalytic site [active] 423368007249 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 423368007250 active site 423368007251 hexamer interface [polypeptide binding]; other site 423368007252 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 423368007253 NAD binding site [chemical binding]; other site 423368007254 substrate binding site [chemical binding]; other site 423368007255 active site 423368007256 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 423368007257 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 423368007258 putative active site [active] 423368007259 putative catalytic site [active] 423368007260 putative Zn binding site [ion binding]; other site 423368007261 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 423368007262 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 423368007263 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 423368007264 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 423368007265 signal transduction protein PmrD; Provisional; Region: PRK15450 423368007266 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 423368007267 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 423368007268 acyl-activating enzyme (AAE) consensus motif; other site 423368007269 putative AMP binding site [chemical binding]; other site 423368007270 putative active site [active] 423368007271 putative CoA binding site [chemical binding]; other site 423368007272 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 423368007273 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 423368007274 active site 423368007275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 423368007276 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 423368007277 substrate binding site [chemical binding]; other site 423368007278 oxyanion hole (OAH) forming residues; other site 423368007279 trimer interface [polypeptide binding]; other site 423368007280 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 423368007281 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 423368007282 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 423368007283 dimer interface [polypeptide binding]; other site 423368007284 tetramer interface [polypeptide binding]; other site 423368007285 PYR/PP interface [polypeptide binding]; other site 423368007286 TPP binding site [chemical binding]; other site 423368007287 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 423368007288 TPP-binding site; other site 423368007289 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 423368007290 isochorismate synthases; Region: isochor_syn; TIGR00543 423368007291 hypothetical protein; Provisional; Region: PRK10404 423368007292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368007293 Coenzyme A binding pocket [chemical binding]; other site 423368007294 ribonuclease BN; Region: true_RNase_BN; TIGR02649 423368007295 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 423368007296 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 423368007297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368007298 active site 423368007299 phosphorylation site [posttranslational modification] 423368007300 intermolecular recognition site; other site 423368007301 dimerization interface [polypeptide binding]; other site 423368007302 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 423368007303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 423368007304 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 423368007305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 423368007306 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 423368007307 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 423368007308 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 423368007309 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 423368007310 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 423368007311 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 423368007312 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 423368007313 4Fe-4S binding domain; Region: Fer4; pfam00037 423368007314 4Fe-4S binding domain; Region: Fer4; pfam00037 423368007315 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 423368007316 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 423368007317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 423368007318 catalytic loop [active] 423368007319 iron binding site [ion binding]; other site 423368007320 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 423368007321 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 423368007322 [4Fe-4S] binding site [ion binding]; other site 423368007323 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 423368007324 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 423368007325 SLBB domain; Region: SLBB; pfam10531 423368007326 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 423368007327 NADH dehydrogenase subunit E; Validated; Region: PRK07539 423368007328 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 423368007329 putative dimer interface [polypeptide binding]; other site 423368007330 [2Fe-2S] cluster binding site [ion binding]; other site 423368007331 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 423368007332 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 423368007333 NADH dehydrogenase subunit D; Validated; Region: PRK06075 423368007334 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 423368007335 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 423368007336 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 423368007337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368007338 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 423368007339 putative dimerization interface [polypeptide binding]; other site 423368007340 aminotransferase AlaT; Validated; Region: PRK09265 423368007341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368007342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368007343 homodimer interface [polypeptide binding]; other site 423368007344 catalytic residue [active] 423368007345 5'-nucleotidase; Provisional; Region: PRK03826 423368007346 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 423368007347 transmembrane helices; other site 423368007348 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 423368007349 TrkA-C domain; Region: TrkA_C; pfam02080 423368007350 TrkA-C domain; Region: TrkA_C; pfam02080 423368007351 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 423368007352 putative phosphatase; Provisional; Region: PRK11587 423368007353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368007354 motif II; other site 423368007355 hypothetical protein; Validated; Region: PRK05445 423368007356 hypothetical protein; Provisional; Region: PRK01816 423368007357 propionate/acetate kinase; Provisional; Region: PRK12379 423368007358 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 423368007359 phosphate acetyltransferase; Reviewed; Region: PRK05632 423368007360 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 423368007361 DRTGG domain; Region: DRTGG; pfam07085 423368007362 phosphate acetyltransferase; Region: pta; TIGR00651 423368007363 hypothetical protein; Provisional; Region: PRK11588 423368007364 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 423368007365 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 423368007366 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 423368007367 PYR/PP interface [polypeptide binding]; other site 423368007368 dimer interface [polypeptide binding]; other site 423368007369 TPP binding site [chemical binding]; other site 423368007370 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 423368007371 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 423368007372 TPP-binding site [chemical binding]; other site 423368007373 dimer interface [polypeptide binding]; other site 423368007374 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 423368007375 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 423368007376 active site 423368007377 P-loop; other site 423368007378 phosphorylation site [posttranslational modification] 423368007379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368007380 active site 423368007381 phosphorylation site [posttranslational modification] 423368007382 Transcriptional regulators [Transcription]; Region: PurR; COG1609 423368007383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368007384 DNA binding site [nucleotide binding] 423368007385 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 423368007386 putative dimerization interface [polypeptide binding]; other site 423368007387 putative ligand binding site [chemical binding]; other site 423368007388 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 423368007389 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 423368007390 nudix motif; other site 423368007391 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 423368007392 active site 423368007393 metal binding site [ion binding]; metal-binding site 423368007394 homotetramer interface [polypeptide binding]; other site 423368007395 glutathione S-transferase; Provisional; Region: PRK15113 423368007396 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 423368007397 C-terminal domain interface [polypeptide binding]; other site 423368007398 GSH binding site (G-site) [chemical binding]; other site 423368007399 dimer interface [polypeptide binding]; other site 423368007400 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 423368007401 N-terminal domain interface [polypeptide binding]; other site 423368007402 putative dimer interface [polypeptide binding]; other site 423368007403 putative substrate binding pocket (H-site) [chemical binding]; other site 423368007404 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 423368007405 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 423368007406 C-terminal domain interface [polypeptide binding]; other site 423368007407 GSH binding site (G-site) [chemical binding]; other site 423368007408 dimer interface [polypeptide binding]; other site 423368007409 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 423368007410 N-terminal domain interface [polypeptide binding]; other site 423368007411 putative dimer interface [polypeptide binding]; other site 423368007412 active site 423368007413 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 423368007414 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 423368007415 putative NAD(P) binding site [chemical binding]; other site 423368007416 putative active site [active] 423368007417 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 423368007418 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 423368007419 Walker A/P-loop; other site 423368007420 ATP binding site [chemical binding]; other site 423368007421 Q-loop/lid; other site 423368007422 ABC transporter signature motif; other site 423368007423 Walker B; other site 423368007424 D-loop; other site 423368007425 H-loop/switch region; other site 423368007426 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368007427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368007428 dimer interface [polypeptide binding]; other site 423368007429 conserved gate region; other site 423368007430 putative PBP binding loops; other site 423368007431 ABC-ATPase subunit interface; other site 423368007432 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 423368007433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368007434 dimer interface [polypeptide binding]; other site 423368007435 conserved gate region; other site 423368007436 putative PBP binding loops; other site 423368007437 ABC-ATPase subunit interface; other site 423368007438 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 423368007439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368007440 substrate binding pocket [chemical binding]; other site 423368007441 membrane-bound complex binding site; other site 423368007442 hinge residues; other site 423368007443 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 423368007444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368007445 substrate binding pocket [chemical binding]; other site 423368007446 membrane-bound complex binding site; other site 423368007447 hinge residues; other site 423368007448 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 423368007449 Flavoprotein; Region: Flavoprotein; pfam02441 423368007450 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 423368007451 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 423368007452 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 423368007453 dimer interface [polypeptide binding]; other site 423368007454 active site 423368007455 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368007456 substrate binding site [chemical binding]; other site 423368007457 catalytic residue [active] 423368007458 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 423368007459 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 423368007460 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 423368007461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368007462 catalytic residue [active] 423368007463 PAS fold; Region: PAS_4; pfam08448 423368007464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 423368007465 putative active site [active] 423368007466 heme pocket [chemical binding]; other site 423368007467 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 423368007468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368007469 Walker A motif; other site 423368007470 ATP binding site [chemical binding]; other site 423368007471 Walker B motif; other site 423368007472 arginine finger; other site 423368007473 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 423368007474 amidophosphoribosyltransferase; Provisional; Region: PRK09246 423368007475 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 423368007476 active site 423368007477 tetramer interface [polypeptide binding]; other site 423368007478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368007479 active site 423368007480 colicin V production protein; Provisional; Region: PRK10845 423368007481 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 423368007482 cell division protein DedD; Provisional; Region: PRK11633 423368007483 Sporulation related domain; Region: SPOR; pfam05036 423368007484 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 423368007485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 423368007486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 423368007487 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 423368007488 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 423368007489 hypothetical protein; Provisional; Region: PRK10847 423368007490 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 423368007491 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 423368007492 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 423368007493 dimerization interface 3.5A [polypeptide binding]; other site 423368007494 active site 423368007495 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 423368007496 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 423368007497 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 423368007498 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 423368007499 ligand binding site [chemical binding]; other site 423368007500 NAD binding site [chemical binding]; other site 423368007501 catalytic site [active] 423368007502 homodimer interface [polypeptide binding]; other site 423368007503 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 423368007504 putative transporter; Provisional; Region: PRK12382 423368007505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007506 putative substrate translocation pore; other site 423368007507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368007508 non-specific DNA binding site [nucleotide binding]; other site 423368007509 salt bridge; other site 423368007510 sequence-specific DNA binding site [nucleotide binding]; other site 423368007511 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 423368007512 CAAX protease self-immunity; Region: Abi; pfam02517 423368007513 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 423368007514 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 423368007515 dimer interface [polypeptide binding]; other site 423368007516 active site 423368007517 Uncharacterized conserved protein [Function unknown]; Region: COG4121 423368007518 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 423368007519 YfcL protein; Region: YfcL; pfam08891 423368007520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 423368007521 hypothetical protein; Provisional; Region: PRK10621 423368007522 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 423368007523 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 423368007524 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 423368007525 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 423368007526 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 423368007527 Tetramer interface [polypeptide binding]; other site 423368007528 active site 423368007529 FMN-binding site [chemical binding]; other site 423368007530 HemK family putative methylases; Region: hemK_fam; TIGR00536 423368007531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368007532 S-adenosylmethionine binding site [chemical binding]; other site 423368007533 hypothetical protein; Provisional; Region: PRK04946 423368007534 Smr domain; Region: Smr; pfam01713 423368007535 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 423368007536 catalytic core [active] 423368007537 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 423368007538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 423368007539 substrate binding site [chemical binding]; other site 423368007540 oxyanion hole (OAH) forming residues; other site 423368007541 trimer interface [polypeptide binding]; other site 423368007542 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 423368007543 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 423368007544 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 423368007545 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 423368007546 dimer interface [polypeptide binding]; other site 423368007547 active site 423368007548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 423368007549 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 423368007550 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 423368007551 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 423368007552 outer membrane protease; Reviewed; Region: PRK10993 423368007553 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 423368007554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368007555 active site 423368007556 phosphorylation site [posttranslational modification] 423368007557 intermolecular recognition site; other site 423368007558 dimerization interface [polypeptide binding]; other site 423368007559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 423368007560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 423368007561 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 423368007562 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 423368007563 dimerization interface [polypeptide binding]; other site 423368007564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368007565 dimer interface [polypeptide binding]; other site 423368007566 phosphorylation site [posttranslational modification] 423368007567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368007568 ATP binding site [chemical binding]; other site 423368007569 Mg2+ binding site [ion binding]; other site 423368007570 G-X-G motif; other site 423368007571 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 423368007572 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 423368007573 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 423368007574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007576 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 423368007577 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 423368007578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 423368007579 putative acyl-acceptor binding pocket; other site 423368007580 aminotransferase; Validated; Region: PRK08175 423368007581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368007582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368007583 homodimer interface [polypeptide binding]; other site 423368007584 catalytic residue [active] 423368007585 glucokinase; Provisional; Region: glk; PRK00292 423368007586 glucokinase, proteobacterial type; Region: glk; TIGR00749 423368007587 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 423368007588 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 423368007589 Cl- selectivity filter; other site 423368007590 Cl- binding residues [ion binding]; other site 423368007591 pore gating glutamate residue; other site 423368007592 dimer interface [polypeptide binding]; other site 423368007593 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 423368007594 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 423368007595 dimer interface [polypeptide binding]; other site 423368007596 PYR/PP interface [polypeptide binding]; other site 423368007597 TPP binding site [chemical binding]; other site 423368007598 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 423368007599 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 423368007600 TPP-binding site [chemical binding]; other site 423368007601 dimer interface [polypeptide binding]; other site 423368007602 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368007603 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368007604 active site 423368007605 catalytic tetrad [active] 423368007606 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 423368007607 manganese transport protein MntH; Reviewed; Region: PRK00701 423368007608 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 423368007609 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 423368007610 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 423368007611 Nucleoside recognition; Region: Gate; pfam07670 423368007612 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 423368007613 MASE1; Region: MASE1; pfam05231 423368007614 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 423368007615 diguanylate cyclase; Region: GGDEF; smart00267 423368007616 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368007617 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 423368007618 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 423368007619 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 423368007620 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 423368007621 active site 423368007622 HIGH motif; other site 423368007623 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 423368007624 active site 423368007625 KMSKS motif; other site 423368007626 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 423368007627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368007628 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 423368007629 putative dimerization interface [polypeptide binding]; other site 423368007630 putative substrate binding pocket [chemical binding]; other site 423368007631 XapX domain; Region: XapX; TIGR03510 423368007632 nucleoside transporter; Region: 2A0110; TIGR00889 423368007633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368007634 putative substrate translocation pore; other site 423368007635 purine nucleoside phosphorylase; Provisional; Region: PRK08202 423368007636 hypothetical protein; Provisional; Region: PRK11528 423368007637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368007638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368007639 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 423368007640 putative dimerization interface [polypeptide binding]; other site 423368007641 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 423368007642 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 423368007643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 423368007644 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 423368007645 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 423368007646 nucleotide binding pocket [chemical binding]; other site 423368007647 K-X-D-G motif; other site 423368007648 catalytic site [active] 423368007649 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 423368007650 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 423368007651 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 423368007652 Dimer interface [polypeptide binding]; other site 423368007653 BRCT sequence motif; other site 423368007654 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 423368007655 cell division protein ZipA; Provisional; Region: PRK03427 423368007656 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 423368007657 FtsZ protein binding site [polypeptide binding]; other site 423368007658 putative sulfate transport protein CysZ; Validated; Region: PRK04949 423368007659 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 423368007660 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 423368007661 dimer interface [polypeptide binding]; other site 423368007662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368007663 catalytic residue [active] 423368007664 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 423368007665 dimerization domain swap beta strand [polypeptide binding]; other site 423368007666 regulatory protein interface [polypeptide binding]; other site 423368007667 active site 423368007668 regulatory phosphorylation site [posttranslational modification]; other site 423368007669 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 423368007670 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 423368007671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 423368007672 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 423368007673 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 423368007674 HPr interaction site; other site 423368007675 glycerol kinase (GK) interaction site [polypeptide binding]; other site 423368007676 active site 423368007677 phosphorylation site [posttranslational modification] 423368007678 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 423368007679 dimer interface [polypeptide binding]; other site 423368007680 pyridoxamine kinase; Validated; Region: PRK05756 423368007681 pyridoxal binding site [chemical binding]; other site 423368007682 ATP binding site [chemical binding]; other site 423368007683 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 423368007684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368007685 DNA-binding site [nucleotide binding]; DNA binding site 423368007686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368007687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368007688 homodimer interface [polypeptide binding]; other site 423368007689 catalytic residue [active] 423368007690 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 423368007691 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 423368007692 catalytic triad [active] 423368007693 hypothetical protein; Provisional; Region: PRK10318 423368007694 Transglycosylase; Region: Transgly; cl17702 423368007695 cysteine synthase B; Region: cysM; TIGR01138 423368007696 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 423368007697 dimer interface [polypeptide binding]; other site 423368007698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368007699 catalytic residue [active] 423368007700 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 423368007701 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 423368007702 Walker A/P-loop; other site 423368007703 ATP binding site [chemical binding]; other site 423368007704 Q-loop/lid; other site 423368007705 ABC transporter signature motif; other site 423368007706 Walker B; other site 423368007707 D-loop; other site 423368007708 H-loop/switch region; other site 423368007709 TOBE-like domain; Region: TOBE_3; pfam12857 423368007710 sulfate transport protein; Provisional; Region: cysT; CHL00187 423368007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368007712 dimer interface [polypeptide binding]; other site 423368007713 conserved gate region; other site 423368007714 putative PBP binding loops; other site 423368007715 ABC-ATPase subunit interface; other site 423368007716 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 423368007717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368007718 dimer interface [polypeptide binding]; other site 423368007719 conserved gate region; other site 423368007720 putative PBP binding loops; other site 423368007721 ABC-ATPase subunit interface; other site 423368007722 thiosulfate transporter subunit; Provisional; Region: PRK10852 423368007723 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 423368007724 short chain dehydrogenase; Provisional; Region: PRK08226 423368007725 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 423368007726 NAD binding site [chemical binding]; other site 423368007727 homotetramer interface [polypeptide binding]; other site 423368007728 homodimer interface [polypeptide binding]; other site 423368007729 active site 423368007730 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 423368007731 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 423368007732 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 423368007733 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 423368007734 putative acetyltransferase; Provisional; Region: PRK03624 423368007735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368007736 Coenzyme A binding pocket [chemical binding]; other site 423368007737 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 423368007738 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 423368007739 active site 423368007740 metal binding site [ion binding]; metal-binding site 423368007741 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 423368007742 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 423368007743 transcriptional regulator EutR; Provisional; Region: PRK10130 423368007744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368007745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368007746 carboxysome structural protein EutK; Provisional; Region: PRK15466 423368007747 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 423368007748 Hexamer interface [polypeptide binding]; other site 423368007749 Hexagonal pore residue; other site 423368007750 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 423368007751 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 423368007752 putative hexamer interface [polypeptide binding]; other site 423368007753 putative hexagonal pore; other site 423368007754 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 423368007755 putative hexamer interface [polypeptide binding]; other site 423368007756 putative hexagonal pore; other site 423368007757 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 423368007758 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 423368007759 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 423368007760 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 423368007761 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 423368007762 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 423368007763 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 423368007764 active site 423368007765 metal binding site [ion binding]; metal-binding site 423368007766 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 423368007767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368007768 nucleotide binding site [chemical binding]; other site 423368007769 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 423368007770 putative catalytic cysteine [active] 423368007771 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 423368007772 Hexamer/Pentamer interface [polypeptide binding]; other site 423368007773 central pore; other site 423368007774 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 423368007775 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 423368007776 Hexamer interface [polypeptide binding]; other site 423368007777 Putative hexagonal pore residue; other site 423368007778 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 423368007779 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 423368007780 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 423368007781 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 423368007782 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 423368007783 G1 box; other site 423368007784 GTP/Mg2+ binding site [chemical binding]; other site 423368007785 G2 box; other site 423368007786 Switch I region; other site 423368007787 G3 box; other site 423368007788 Switch II region; other site 423368007789 G4 box; other site 423368007790 G5 box; other site 423368007791 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 423368007792 putative hexamer interface [polypeptide binding]; other site 423368007793 putative hexagonal pore; other site 423368007794 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 423368007795 Malic enzyme, N-terminal domain; Region: malic; pfam00390 423368007796 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 423368007797 putative NAD(P) binding site [chemical binding]; other site 423368007798 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 423368007799 transaldolase-like protein; Provisional; Region: PTZ00411 423368007800 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 423368007801 active site 423368007802 dimer interface [polypeptide binding]; other site 423368007803 catalytic residue [active] 423368007804 transketolase; Reviewed; Region: PRK12753 423368007805 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 423368007806 TPP-binding site [chemical binding]; other site 423368007807 dimer interface [polypeptide binding]; other site 423368007808 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 423368007809 PYR/PP interface [polypeptide binding]; other site 423368007810 dimer interface [polypeptide binding]; other site 423368007811 TPP binding site [chemical binding]; other site 423368007812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 423368007813 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 423368007814 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 423368007815 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 423368007816 dimer interface [polypeptide binding]; other site 423368007817 ADP-ribose binding site [chemical binding]; other site 423368007818 active site 423368007819 nudix motif; other site 423368007820 metal binding site [ion binding]; metal-binding site 423368007821 putative periplasmic esterase; Provisional; Region: PRK03642 423368007822 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 423368007823 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 423368007824 4Fe-4S binding domain; Region: Fer4; pfam00037 423368007825 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 423368007826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368007827 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 423368007828 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 423368007829 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368007830 dimerization interface [polypeptide binding]; other site 423368007831 Histidine kinase; Region: HisKA_3; pfam07730 423368007832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368007833 ATP binding site [chemical binding]; other site 423368007834 Mg2+ binding site [ion binding]; other site 423368007835 G-X-G motif; other site 423368007836 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 423368007837 Protein export membrane protein; Region: SecD_SecF; cl14618 423368007838 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 423368007839 ArsC family; Region: ArsC; pfam03960 423368007840 putative catalytic residues [active] 423368007841 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 423368007842 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 423368007843 metal binding site [ion binding]; metal-binding site 423368007844 dimer interface [polypeptide binding]; other site 423368007845 hypothetical protein; Provisional; Region: PRK13664 423368007846 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 423368007847 Helicase; Region: Helicase_RecD; pfam05127 423368007848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368007849 Coenzyme A binding pocket [chemical binding]; other site 423368007850 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 423368007851 Predicted metalloprotease [General function prediction only]; Region: COG2321 423368007852 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 423368007853 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 423368007854 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 423368007855 ATP binding site [chemical binding]; other site 423368007856 active site 423368007857 substrate binding site [chemical binding]; other site 423368007858 lipoprotein; Provisional; Region: PRK11679 423368007859 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 423368007860 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 423368007861 dihydrodipicolinate synthase; Region: dapA; TIGR00674 423368007862 dimer interface [polypeptide binding]; other site 423368007863 active site 423368007864 catalytic residue [active] 423368007865 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 423368007866 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 423368007867 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 423368007868 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 423368007869 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 423368007870 catalytic triad [active] 423368007871 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 423368007872 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 423368007873 fructuronate transporter; Provisional; Region: PRK10034; cl15264 423368007874 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 423368007875 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 423368007876 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 423368007877 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 423368007878 Domain of unknown function DUF20; Region: UPF0118; pfam01594 423368007879 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 423368007880 Peptidase family M48; Region: Peptidase_M48; cl12018 423368007881 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 423368007882 ArsC family; Region: ArsC; pfam03960 423368007883 catalytic residues [active] 423368007884 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 423368007885 DNA replication initiation factor; Provisional; Region: PRK08084 423368007886 uracil transporter; Provisional; Region: PRK10720 423368007887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368007888 active site 423368007889 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 423368007890 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 423368007891 dimerization interface [polypeptide binding]; other site 423368007892 putative ATP binding site [chemical binding]; other site 423368007893 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 423368007894 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 423368007895 active site 423368007896 substrate binding site [chemical binding]; other site 423368007897 cosubstrate binding site; other site 423368007898 catalytic site [active] 423368007899 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 423368007900 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 423368007901 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 423368007902 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 423368007903 putative active site [active] 423368007904 catalytic site [active] 423368007905 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 423368007906 domain interface [polypeptide binding]; other site 423368007907 active site 423368007908 catalytic site [active] 423368007909 exopolyphosphatase; Provisional; Region: PRK10854 423368007910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368007911 nucleotide binding site [chemical binding]; other site 423368007912 MASE1; Region: MASE1; pfam05231 423368007913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 423368007914 diguanylate cyclase; Region: GGDEF; smart00267 423368007915 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368007916 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 423368007917 Integrase core domain; Region: rve; pfam00665 423368007918 GMP synthase; Reviewed; Region: guaA; PRK00074 423368007919 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 423368007920 AMP/PPi binding site [chemical binding]; other site 423368007921 candidate oxyanion hole; other site 423368007922 catalytic triad [active] 423368007923 potential glutamine specificity residues [chemical binding]; other site 423368007924 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 423368007925 ATP Binding subdomain [chemical binding]; other site 423368007926 Ligand Binding sites [chemical binding]; other site 423368007927 Dimerization subdomain; other site 423368007928 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 423368007929 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 423368007930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 423368007931 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 423368007932 active site 423368007933 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 423368007934 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 423368007935 generic binding surface II; other site 423368007936 generic binding surface I; other site 423368007937 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 423368007938 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 423368007939 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 423368007940 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 423368007941 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 423368007942 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 423368007943 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 423368007944 Autotransporter beta-domain; Region: Autotransporter; smart00869 423368007945 outer membrane protein RatB; Provisional; Region: PRK15314 423368007946 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007947 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007948 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007949 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007950 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007951 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007952 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007953 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007954 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007955 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007956 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007957 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007958 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007959 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007960 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007961 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007962 outer membrane protein RatA; Provisional; Region: PRK15315 423368007963 Oxygen tolerance; Region: BatD; pfam13584 423368007964 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007965 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007966 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007967 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007968 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007969 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007970 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007971 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007972 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007973 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 423368007974 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 423368007975 intimin-like protein SinH; Provisional; Region: PRK15318 423368007976 intimin-like protein SinH; Provisional; Region: PRK15318 423368007977 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 423368007978 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 423368007979 GTP-binding protein Der; Reviewed; Region: PRK00093 423368007980 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 423368007981 G1 box; other site 423368007982 GTP/Mg2+ binding site [chemical binding]; other site 423368007983 Switch I region; other site 423368007984 G2 box; other site 423368007985 Switch II region; other site 423368007986 G3 box; other site 423368007987 G4 box; other site 423368007988 G5 box; other site 423368007989 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 423368007990 G1 box; other site 423368007991 GTP/Mg2+ binding site [chemical binding]; other site 423368007992 Switch I region; other site 423368007993 G2 box; other site 423368007994 G3 box; other site 423368007995 Switch II region; other site 423368007996 G4 box; other site 423368007997 G5 box; other site 423368007998 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 423368007999 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 423368008000 Trp docking motif [polypeptide binding]; other site 423368008001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 423368008002 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 423368008003 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 423368008004 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 423368008005 dimer interface [polypeptide binding]; other site 423368008006 motif 1; other site 423368008007 active site 423368008008 motif 2; other site 423368008009 motif 3; other site 423368008010 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 423368008011 anticodon binding site; other site 423368008012 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 423368008013 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 423368008014 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 423368008015 cytoskeletal protein RodZ; Provisional; Region: PRK10856 423368008016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368008017 non-specific DNA binding site [nucleotide binding]; other site 423368008018 salt bridge; other site 423368008019 sequence-specific DNA binding site [nucleotide binding]; other site 423368008020 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 423368008021 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 423368008022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368008023 FeS/SAM binding site; other site 423368008024 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 423368008025 active site 423368008026 multimer interface [polypeptide binding]; other site 423368008027 4Fe-4S binding domain; Region: Fer4; pfam00037 423368008028 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 423368008029 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 423368008030 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 423368008031 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 423368008032 4Fe-4S binding domain; Region: Fer4; pfam00037 423368008033 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 423368008034 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 423368008035 putative [Fe4-S4] binding site [ion binding]; other site 423368008036 putative molybdopterin cofactor binding site [chemical binding]; other site 423368008037 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 423368008038 putative molybdopterin cofactor binding site; other site 423368008039 penicillin-binding protein 1C; Provisional; Region: PRK11240 423368008040 Transglycosylase; Region: Transgly; pfam00912 423368008041 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 423368008042 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 423368008043 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 423368008044 MG2 domain; Region: A2M_N; pfam01835 423368008045 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 423368008046 surface patch; other site 423368008047 thioester region; other site 423368008048 specificity defining residues; other site 423368008049 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 423368008050 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 423368008051 active site residue [active] 423368008052 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 423368008053 active site residue [active] 423368008054 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 423368008055 aminopeptidase B; Provisional; Region: PRK05015 423368008056 Peptidase; Region: DUF3663; pfam12404 423368008057 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 423368008058 interface (dimer of trimers) [polypeptide binding]; other site 423368008059 Substrate-binding/catalytic site; other site 423368008060 Zn-binding sites [ion binding]; other site 423368008061 hypothetical protein; Provisional; Region: PRK10721 423368008062 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 423368008063 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 423368008064 catalytic loop [active] 423368008065 iron binding site [ion binding]; other site 423368008066 chaperone protein HscA; Provisional; Region: hscA; PRK05183 423368008067 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 423368008068 nucleotide binding site [chemical binding]; other site 423368008069 putative NEF/HSP70 interaction site [polypeptide binding]; other site 423368008070 SBD interface [polypeptide binding]; other site 423368008071 co-chaperone HscB; Provisional; Region: hscB; PRK05014 423368008072 DnaJ domain; Region: DnaJ; pfam00226 423368008073 HSP70 interaction site [polypeptide binding]; other site 423368008074 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 423368008075 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 423368008076 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 423368008077 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 423368008078 trimerization site [polypeptide binding]; other site 423368008079 active site 423368008080 cysteine desulfurase; Provisional; Region: PRK14012 423368008081 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 423368008082 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368008083 catalytic residue [active] 423368008084 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 423368008085 Rrf2 family protein; Region: rrf2_super; TIGR00738 423368008086 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 423368008087 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 423368008088 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 423368008089 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 423368008090 active site 423368008091 dimerization interface [polypeptide binding]; other site 423368008092 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 423368008093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 423368008094 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 423368008095 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368008096 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 423368008097 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 423368008098 FAD binding pocket [chemical binding]; other site 423368008099 FAD binding motif [chemical binding]; other site 423368008100 phosphate binding motif [ion binding]; other site 423368008101 beta-alpha-beta structure motif; other site 423368008102 NAD binding pocket [chemical binding]; other site 423368008103 Iron coordination center [ion binding]; other site 423368008104 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 423368008105 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 423368008106 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368008107 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 423368008108 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 423368008109 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 423368008110 PRD domain; Region: PRD; pfam00874 423368008111 PRD domain; Region: PRD; pfam00874 423368008112 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 423368008113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008114 putative substrate translocation pore; other site 423368008115 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 423368008116 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 423368008117 dimer interface [polypeptide binding]; other site 423368008118 active site 423368008119 glycine-pyridoxal phosphate binding site [chemical binding]; other site 423368008120 folate binding site [chemical binding]; other site 423368008121 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 423368008122 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 423368008123 heme-binding site [chemical binding]; other site 423368008124 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 423368008125 FAD binding pocket [chemical binding]; other site 423368008126 FAD binding motif [chemical binding]; other site 423368008127 phosphate binding motif [ion binding]; other site 423368008128 beta-alpha-beta structure motif; other site 423368008129 NAD binding pocket [chemical binding]; other site 423368008130 Heme binding pocket [chemical binding]; other site 423368008131 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 423368008132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368008133 DNA binding site [nucleotide binding] 423368008134 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 423368008135 lysine decarboxylase CadA; Provisional; Region: PRK15400 423368008136 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 423368008137 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 423368008138 homodimer interface [polypeptide binding]; other site 423368008139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368008140 catalytic residue [active] 423368008141 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 423368008142 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 423368008143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008144 putative substrate translocation pore; other site 423368008145 POT family; Region: PTR2; pfam00854 423368008146 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 423368008147 Nitrogen regulatory protein P-II; Region: P-II; smart00938 423368008148 response regulator GlrR; Provisional; Region: PRK15115 423368008149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368008150 active site 423368008151 phosphorylation site [posttranslational modification] 423368008152 intermolecular recognition site; other site 423368008153 dimerization interface [polypeptide binding]; other site 423368008154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368008155 Walker A motif; other site 423368008156 ATP binding site [chemical binding]; other site 423368008157 Walker B motif; other site 423368008158 arginine finger; other site 423368008159 hypothetical protein; Provisional; Region: PRK10722 423368008160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 423368008161 HAMP domain; Region: HAMP; pfam00672 423368008162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368008163 dimer interface [polypeptide binding]; other site 423368008164 phosphorylation site [posttranslational modification] 423368008165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368008166 ATP binding site [chemical binding]; other site 423368008167 Mg2+ binding site [ion binding]; other site 423368008168 G-X-G motif; other site 423368008169 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 423368008170 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 423368008171 dimerization interface [polypeptide binding]; other site 423368008172 ATP binding site [chemical binding]; other site 423368008173 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 423368008174 dimerization interface [polypeptide binding]; other site 423368008175 ATP binding site [chemical binding]; other site 423368008176 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 423368008177 putative active site [active] 423368008178 catalytic triad [active] 423368008179 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 423368008180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368008181 substrate binding pocket [chemical binding]; other site 423368008182 membrane-bound complex binding site; other site 423368008183 hinge residues; other site 423368008184 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368008185 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368008186 catalytic residue [active] 423368008187 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 423368008188 nucleoside/Zn binding site; other site 423368008189 dimer interface [polypeptide binding]; other site 423368008190 catalytic motif [active] 423368008191 hypothetical protein; Provisional; Region: PRK11590 423368008192 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 423368008193 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 423368008194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 423368008195 active site turn [active] 423368008196 phosphorylation site [posttranslational modification] 423368008197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 423368008198 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 423368008199 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 423368008200 putative active site [active] 423368008201 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 423368008202 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 423368008203 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 423368008204 putative active site [active] 423368008205 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 423368008206 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 423368008207 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 423368008208 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 423368008209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008210 putative substrate translocation pore; other site 423368008211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368008212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368008213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368008214 dimerization interface [polypeptide binding]; other site 423368008215 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 423368008216 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 423368008217 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 423368008218 active site 423368008219 hydrophilic channel; other site 423368008220 dimerization interface [polypeptide binding]; other site 423368008221 catalytic residues [active] 423368008222 active site lid [active] 423368008223 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 423368008224 Recombination protein O N terminal; Region: RecO_N; pfam11967 423368008225 Recombination protein O C terminal; Region: RecO_C; pfam02565 423368008226 GTPase Era; Reviewed; Region: era; PRK00089 423368008227 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 423368008228 G1 box; other site 423368008229 GTP/Mg2+ binding site [chemical binding]; other site 423368008230 Switch I region; other site 423368008231 G2 box; other site 423368008232 Switch II region; other site 423368008233 G3 box; other site 423368008234 G4 box; other site 423368008235 G5 box; other site 423368008236 KH domain; Region: KH_2; pfam07650 423368008237 ribonuclease III; Reviewed; Region: rnc; PRK00102 423368008238 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 423368008239 dimerization interface [polypeptide binding]; other site 423368008240 active site 423368008241 metal binding site [ion binding]; metal-binding site 423368008242 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 423368008243 dsRNA binding site [nucleotide binding]; other site 423368008244 rncO 423368008245 signal peptidase I; Provisional; Region: PRK10861 423368008246 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 423368008247 Catalytic site [active] 423368008248 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 423368008249 GTP-binding protein LepA; Provisional; Region: PRK05433 423368008250 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 423368008251 G1 box; other site 423368008252 putative GEF interaction site [polypeptide binding]; other site 423368008253 GTP/Mg2+ binding site [chemical binding]; other site 423368008254 Switch I region; other site 423368008255 G2 box; other site 423368008256 G3 box; other site 423368008257 Switch II region; other site 423368008258 G4 box; other site 423368008259 G5 box; other site 423368008260 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 423368008261 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 423368008262 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 423368008263 type III secretion protein GogB; Provisional; Region: PRK15386 423368008264 Integrase core domain; Region: rve_3; cl15866 423368008265 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368008266 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 423368008267 ADP-ribose binding site [chemical binding]; other site 423368008268 putative active site [active] 423368008269 dimer interface [polypeptide binding]; other site 423368008270 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 423368008271 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368008272 Phage Tail Collar Domain; Region: Collar; pfam07484 423368008273 Phage-related protein, tail component [Function unknown]; Region: COG4733 423368008274 Putative phage tail protein; Region: Phage-tail_3; pfam13550 423368008275 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 423368008276 Interdomain contacts; other site 423368008277 Cytokine receptor motif; other site 423368008278 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 423368008279 Fibronectin type III protein; Region: DUF3672; pfam12421 423368008280 Phage-related protein, tail component [Function unknown]; Region: COG4723 423368008281 Phage-related protein [Function unknown]; Region: gp18; COG4672 423368008282 Phage-related protein [Function unknown]; Region: COG4718 423368008283 Phage-related minor tail protein [Function unknown]; Region: COG5281 423368008284 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 423368008285 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 423368008286 Minor tail protein T; Region: Phage_tail_T; cl05636 423368008287 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 423368008288 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 423368008289 Phage tail protein; Region: Phage_tail_3; pfam08813 423368008290 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 423368008291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 423368008292 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 423368008293 Probable transposase; Region: OrfB_IS605; pfam01385 423368008294 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 423368008295 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 423368008296 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 423368008297 DNA packaging protein FI; Region: Packaging_FI; pfam14000 423368008298 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 423368008299 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 423368008300 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 423368008301 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 423368008302 tandem repeat interface [polypeptide binding]; other site 423368008303 oligomer interface [polypeptide binding]; other site 423368008304 active site residues [active] 423368008305 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 423368008306 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 423368008307 gpW; Region: gpW; pfam02831 423368008308 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 423368008309 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 423368008310 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 423368008311 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 423368008312 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 423368008313 catalytic residues [active] 423368008314 phage holin, lambda family; Region: holin_lambda; TIGR01594 423368008315 PipA protein; Region: PipA; pfam07108 423368008316 ORF6N domain; Region: ORF6N; pfam10543 423368008317 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 423368008318 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 423368008319 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 423368008320 DinI-like family; Region: DinI; pfam06183 423368008321 Protein of unknown function (DUF550); Region: DUF550; pfam04447 423368008322 Replication protein P; Region: Phage_lambda_P; pfam06992 423368008323 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 423368008324 Bacteriophage CII protein; Region: Phage_CII; pfam05269 423368008325 AAA domain; Region: AAA_31; pfam13614 423368008326 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 423368008327 P-loop; other site 423368008328 Magnesium ion binding site [ion binding]; other site 423368008329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 423368008330 Magnesium ion binding site [ion binding]; other site 423368008331 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 423368008332 exonuclease VIII; Reviewed; Region: PRK09709 423368008333 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 423368008334 RecT family; Region: RecT; pfam03837 423368008335 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 423368008336 integrase; Provisional; Region: PRK09692 423368008337 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 423368008338 active site 423368008339 Int/Topo IB signature motif; other site 423368008340 SoxR reducing system protein RseC; Provisional; Region: PRK10862 423368008341 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 423368008342 anti-sigma E factor; Provisional; Region: rseB; PRK09455 423368008343 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 423368008344 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 423368008345 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 423368008346 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 423368008347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 423368008348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 423368008349 DNA binding residues [nucleotide binding] 423368008350 L-aspartate oxidase; Provisional; Region: PRK09077 423368008351 L-aspartate oxidase; Provisional; Region: PRK06175 423368008352 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 423368008353 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 423368008354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368008355 S-adenosylmethionine binding site [chemical binding]; other site 423368008356 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 423368008357 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 423368008358 ATP binding site [chemical binding]; other site 423368008359 Mg++ binding site [ion binding]; other site 423368008360 motif III; other site 423368008361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368008362 nucleotide binding region [chemical binding]; other site 423368008363 ATP-binding site [chemical binding]; other site 423368008364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368008365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368008366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368008367 dimerization interface [polypeptide binding]; other site 423368008368 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 423368008369 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 423368008370 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 423368008371 ligand binding site [chemical binding]; other site 423368008372 active site 423368008373 UGI interface [polypeptide binding]; other site 423368008374 catalytic site [active] 423368008375 putative methyltransferase; Provisional; Region: PRK10864 423368008376 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 423368008377 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 423368008378 thioredoxin 2; Provisional; Region: PRK10996 423368008379 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 423368008380 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 423368008381 catalytic residues [active] 423368008382 Uncharacterized conserved protein [Function unknown]; Region: COG3148 423368008383 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 423368008384 CoA binding domain; Region: CoA_binding_2; pfam13380 423368008385 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 423368008386 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 423368008387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 423368008388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368008389 Coenzyme A binding pocket [chemical binding]; other site 423368008390 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 423368008391 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 423368008392 domain interface [polypeptide binding]; other site 423368008393 putative active site [active] 423368008394 catalytic site [active] 423368008395 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 423368008396 domain interface [polypeptide binding]; other site 423368008397 putative active site [active] 423368008398 catalytic site [active] 423368008399 lipoprotein; Provisional; Region: PRK10759 423368008400 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 423368008401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008402 putative substrate translocation pore; other site 423368008403 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 423368008404 protein disaggregation chaperone; Provisional; Region: PRK10865 423368008405 Clp amino terminal domain; Region: Clp_N; pfam02861 423368008406 Clp amino terminal domain; Region: Clp_N; pfam02861 423368008407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368008408 Walker A motif; other site 423368008409 ATP binding site [chemical binding]; other site 423368008410 Walker B motif; other site 423368008411 arginine finger; other site 423368008412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368008413 Walker A motif; other site 423368008414 ATP binding site [chemical binding]; other site 423368008415 Walker B motif; other site 423368008416 arginine finger; other site 423368008417 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 423368008418 hypothetical protein; Provisional; Region: PRK10723 423368008419 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 423368008420 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 423368008421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368008422 RNA binding surface [nucleotide binding]; other site 423368008423 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 423368008424 active site 423368008425 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 423368008426 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 423368008427 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 423368008428 30S subunit binding site; other site 423368008429 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 423368008430 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 423368008431 Prephenate dehydratase; Region: PDT; pfam00800 423368008432 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 423368008433 putative L-Phe binding site [chemical binding]; other site 423368008434 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 423368008435 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 423368008436 Chorismate mutase type II; Region: CM_2; cl00693 423368008437 prephenate dehydrogenase; Validated; Region: PRK08507 423368008438 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 423368008439 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 423368008440 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 423368008441 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 423368008442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368008443 metal binding site [ion binding]; metal-binding site 423368008444 active site 423368008445 I-site; other site 423368008446 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 423368008447 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 423368008448 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 423368008449 RimM N-terminal domain; Region: RimM; pfam01782 423368008450 PRC-barrel domain; Region: PRC; pfam05239 423368008451 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 423368008452 signal recognition particle protein; Provisional; Region: PRK10867 423368008453 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 423368008454 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 423368008455 P loop; other site 423368008456 GTP binding site [chemical binding]; other site 423368008457 Signal peptide binding domain; Region: SRP_SPB; pfam02978 423368008458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 423368008459 hypothetical protein; Provisional; Region: PRK11573 423368008460 Domain of unknown function DUF21; Region: DUF21; pfam01595 423368008461 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 423368008462 Transporter associated domain; Region: CorC_HlyC; smart01091 423368008463 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 423368008464 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 423368008465 dimer interface [polypeptide binding]; other site 423368008466 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 423368008467 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 423368008468 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 423368008469 recombination and repair protein; Provisional; Region: PRK10869 423368008470 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 423368008471 Walker A/P-loop; other site 423368008472 ATP binding site [chemical binding]; other site 423368008473 Q-loop/lid; other site 423368008474 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 423368008475 ABC transporter signature motif; other site 423368008476 Walker B; other site 423368008477 D-loop; other site 423368008478 H-loop/switch region; other site 423368008479 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 423368008480 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 423368008481 hypothetical protein; Validated; Region: PRK01777 423368008482 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 423368008483 putative coenzyme Q binding site [chemical binding]; other site 423368008484 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 423368008485 SmpB-tmRNA interface; other site 423368008486 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008487 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008488 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008489 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008490 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008491 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008492 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008493 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008494 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008495 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008496 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008497 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008498 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008499 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368008500 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008501 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368008502 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 423368008503 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 423368008504 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 423368008505 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368008506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368008507 Walker A/P-loop; other site 423368008508 ATP binding site [chemical binding]; other site 423368008509 Q-loop/lid; other site 423368008510 ABC transporter signature motif; other site 423368008511 Walker B; other site 423368008512 D-loop; other site 423368008513 H-loop/switch region; other site 423368008514 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 423368008515 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368008516 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 423368008517 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368008518 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 423368008519 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 423368008520 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368008521 Baseplate J-like protein; Region: Baseplate_J; cl01294 423368008522 Baseplate J-like protein; Region: Baseplate_J; pfam04865 423368008523 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 423368008524 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 423368008525 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 423368008526 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 423368008527 Phage holin family 2; Region: Phage_holin_2; pfam04550 423368008528 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 423368008529 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 423368008530 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 423368008531 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 423368008532 terminase endonuclease subunit; Provisional; Region: M; PHA02537 423368008533 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 423368008534 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 423368008535 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 423368008536 terminase ATPase subunit; Provisional; Region: P; PHA02535 423368008537 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 423368008538 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 423368008539 Phage-related protein [Function unknown]; Region: COG4695; cl01923 423368008540 Phage portal protein; Region: Phage_portal; pfam04860 423368008541 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 423368008542 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 423368008543 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 423368008544 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 423368008545 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 423368008546 threonine ammonia-lyase, medium form; Region: ilvA_1Cterm; TIGR01127 423368008547 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 423368008548 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 423368008549 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 423368008550 integrase; Provisional; Region: int; PHA02601 423368008551 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368008552 active site 423368008553 DNA binding site [nucleotide binding] 423368008554 Int/Topo IB signature motif; other site 423368008555 integrase; Provisional; Region: PRK09692 423368008556 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 423368008557 active site 423368008558 Int/Topo IB signature motif; other site 423368008559 Domain of unknown function DUF87; Region: DUF87; pfam01935 423368008560 HerA helicase [Replication, recombination, and repair]; Region: COG0433 423368008561 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 423368008562 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 423368008563 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 423368008564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 423368008565 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 423368008566 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 423368008567 active site 423368008568 metal binding site [ion binding]; metal-binding site 423368008569 interdomain interaction site; other site 423368008570 D5 N terminal like; Region: D5_N; smart00885 423368008571 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 423368008572 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 423368008573 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 423368008574 flagellin; Validated; Region: PRK08026 423368008575 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 423368008576 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 423368008577 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 423368008578 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 423368008579 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 423368008580 catalytic residues [active] 423368008581 catalytic nucleophile [active] 423368008582 Presynaptic Site I dimer interface [polypeptide binding]; other site 423368008583 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 423368008584 Synaptic Flat tetramer interface [polypeptide binding]; other site 423368008585 Synaptic Site I dimer interface [polypeptide binding]; other site 423368008586 DNA binding site [nucleotide binding] 423368008587 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 423368008588 DNA-binding interface [nucleotide binding]; DNA binding site 423368008589 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 423368008590 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 423368008591 homodimer interface [polypeptide binding]; other site 423368008592 active site 423368008593 TDP-binding site; other site 423368008594 acceptor substrate-binding pocket; other site 423368008595 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 423368008596 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368008597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368008598 Walker A/P-loop; other site 423368008599 ATP binding site [chemical binding]; other site 423368008600 Q-loop/lid; other site 423368008601 ABC transporter signature motif; other site 423368008602 Walker B; other site 423368008603 D-loop; other site 423368008604 H-loop/switch region; other site 423368008605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 423368008606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 423368008607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368008608 Walker A/P-loop; other site 423368008609 ATP binding site [chemical binding]; other site 423368008610 Q-loop/lid; other site 423368008611 ABC transporter signature motif; other site 423368008612 Walker B; other site 423368008613 D-loop; other site 423368008614 H-loop/switch region; other site 423368008615 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 423368008616 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 423368008617 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 423368008618 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 423368008619 outer membrane receptor FepA; Provisional; Region: PRK13528 423368008620 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368008621 N-terminal plug; other site 423368008622 ligand-binding site [chemical binding]; other site 423368008623 secreted effector protein PipB2; Provisional; Region: PRK15196 423368008624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368008625 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368008626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368008627 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368008628 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 423368008629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 423368008630 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 423368008631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 423368008632 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 423368008633 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 423368008634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 423368008635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 423368008636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368008637 dimer interface [polypeptide binding]; other site 423368008638 phosphorylation site [posttranslational modification] 423368008639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368008640 ATP binding site [chemical binding]; other site 423368008641 Mg2+ binding site [ion binding]; other site 423368008642 G-X-G motif; other site 423368008643 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 423368008644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368008645 active site 423368008646 phosphorylation site [posttranslational modification] 423368008647 intermolecular recognition site; other site 423368008648 dimerization interface [polypeptide binding]; other site 423368008649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368008650 DNA binding site [nucleotide binding] 423368008651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 423368008652 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 423368008653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 423368008654 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 423368008655 substrate binding pocket [chemical binding]; other site 423368008656 active site 423368008657 iron coordination sites [ion binding]; other site 423368008658 Predicted dehydrogenase [General function prediction only]; Region: COG0579 423368008659 hydroxyglutarate oxidase; Provisional; Region: PRK11728 423368008660 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 423368008661 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 423368008662 tetramerization interface [polypeptide binding]; other site 423368008663 NAD(P) binding site [chemical binding]; other site 423368008664 catalytic residues [active] 423368008665 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 423368008666 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 423368008667 inhibitor-cofactor binding pocket; inhibition site 423368008668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368008669 catalytic residue [active] 423368008670 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 423368008671 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 423368008672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368008673 DNA-binding site [nucleotide binding]; DNA binding site 423368008674 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 423368008675 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 423368008676 bacterial OsmY and nodulation domain; Region: BON; smart00749 423368008677 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368008678 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 423368008679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368008680 dimerization interface [polypeptide binding]; other site 423368008681 putative DNA binding site [nucleotide binding]; other site 423368008682 Transcriptional regulators [Transcription]; Region: MarR; COG1846 423368008683 putative Zn2+ binding site [ion binding]; other site 423368008684 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 423368008685 active site residue [active] 423368008686 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 423368008687 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 423368008688 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 423368008689 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 423368008690 hypothetical protein; Provisional; Region: PRK10556 423368008691 hypothetical protein; Provisional; Region: PRK10132 423368008692 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 423368008693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368008694 DNA-binding site [nucleotide binding]; DNA binding site 423368008695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368008696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368008697 homodimer interface [polypeptide binding]; other site 423368008698 catalytic residue [active] 423368008699 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 423368008700 Uncharacterized conserved protein [Function unknown]; Region: COG2128 423368008701 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 423368008702 catalytic residues [active] 423368008703 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 423368008704 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 423368008705 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 423368008706 Class I ribonucleotide reductase; Region: RNR_I; cd01679 423368008707 active site 423368008708 dimer interface [polypeptide binding]; other site 423368008709 catalytic residues [active] 423368008710 effector binding site; other site 423368008711 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 423368008712 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 423368008713 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 423368008714 dimer interface [polypeptide binding]; other site 423368008715 putative radical transfer pathway; other site 423368008716 diiron center [ion binding]; other site 423368008717 tyrosyl radical; other site 423368008718 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 423368008719 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 423368008720 Walker A/P-loop; other site 423368008721 ATP binding site [chemical binding]; other site 423368008722 Q-loop/lid; other site 423368008723 ABC transporter signature motif; other site 423368008724 Walker B; other site 423368008725 D-loop; other site 423368008726 H-loop/switch region; other site 423368008727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 423368008728 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 423368008729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368008730 dimer interface [polypeptide binding]; other site 423368008731 conserved gate region; other site 423368008732 putative PBP binding loops; other site 423368008733 ABC-ATPase subunit interface; other site 423368008734 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 423368008735 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 423368008736 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 423368008737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008738 transcriptional repressor MprA; Provisional; Region: PRK10870 423368008739 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 423368008740 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 423368008741 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368008742 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368008743 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 423368008744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008745 putative substrate translocation pore; other site 423368008746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008747 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 423368008748 S-ribosylhomocysteinase; Provisional; Region: PRK02260 423368008749 glutamate--cysteine ligase; Provisional; Region: PRK02107 423368008750 Predicted membrane protein [Function unknown]; Region: COG1238 423368008751 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 423368008752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368008753 motif II; other site 423368008754 carbon storage regulator; Provisional; Region: PRK01712 423368008755 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 423368008756 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 423368008757 motif 1; other site 423368008758 active site 423368008759 motif 2; other site 423368008760 motif 3; other site 423368008761 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 423368008762 DHHA1 domain; Region: DHHA1; pfam02272 423368008763 recombination regulator RecX; Reviewed; Region: recX; PRK00117 423368008764 recombinase A; Provisional; Region: recA; PRK09354 423368008765 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 423368008766 hexamer interface [polypeptide binding]; other site 423368008767 Walker A motif; other site 423368008768 ATP binding site [chemical binding]; other site 423368008769 Walker B motif; other site 423368008770 hypothetical protein; Validated; Region: PRK03661 423368008771 Transglycosylase SLT domain; Region: SLT_2; pfam13406 423368008772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368008773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368008774 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 423368008775 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 423368008776 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 423368008777 Nucleoside recognition; Region: Gate; pfam07670 423368008778 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 423368008779 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 423368008780 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 423368008781 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 423368008782 putative NAD(P) binding site [chemical binding]; other site 423368008783 active site 423368008784 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 423368008785 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 423368008786 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 423368008787 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368008788 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 423368008789 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 423368008790 putative active site [active] 423368008791 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 423368008792 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 423368008793 GAF domain; Region: GAF; pfam01590 423368008794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368008795 Walker A motif; other site 423368008796 ATP binding site [chemical binding]; other site 423368008797 Walker B motif; other site 423368008798 arginine finger; other site 423368008799 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 423368008800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 423368008801 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 423368008802 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 423368008803 iron binding site [ion binding]; other site 423368008804 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 423368008805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368008806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368008807 Acylphosphatase; Region: Acylphosphatase; pfam00708 423368008808 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 423368008809 HypF finger; Region: zf-HYPF; pfam07503 423368008810 HypF finger; Region: zf-HYPF; pfam07503 423368008811 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 423368008812 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 423368008813 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 423368008814 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 423368008815 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 423368008816 nickel binding site [ion binding]; other site 423368008817 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 423368008818 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 423368008819 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 423368008820 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 423368008821 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 423368008822 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 423368008823 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 423368008824 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 423368008825 NADH dehydrogenase; Region: NADHdh; cl00469 423368008826 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 423368008827 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 423368008828 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 423368008829 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 423368008830 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 423368008831 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 423368008832 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 423368008833 hydrogenase assembly chaperone; Provisional; Region: PRK10409 423368008834 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 423368008835 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 423368008836 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 423368008837 dimerization interface [polypeptide binding]; other site 423368008838 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 423368008839 ATP binding site [chemical binding]; other site 423368008840 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 423368008841 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 423368008842 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 423368008843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368008844 Walker A motif; other site 423368008845 ATP binding site [chemical binding]; other site 423368008846 Walker B motif; other site 423368008847 arginine finger; other site 423368008848 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 423368008849 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 423368008850 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 423368008851 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 423368008852 metal binding site [ion binding]; metal-binding site 423368008853 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 423368008854 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 423368008855 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 423368008856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368008857 ABC-ATPase subunit interface; other site 423368008858 dimer interface [polypeptide binding]; other site 423368008859 putative PBP binding regions; other site 423368008860 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 423368008861 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 423368008862 ABC-ATPase subunit interface; other site 423368008863 dimer interface [polypeptide binding]; other site 423368008864 putative PBP binding regions; other site 423368008865 transcriptional activator SprB; Provisional; Region: PRK15320 423368008866 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 423368008867 transcriptional regulator SirC; Provisional; Region: PRK15044 423368008868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368008869 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 423368008870 invasion protein OrgB; Provisional; Region: PRK15322 423368008871 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 423368008872 invasion protein OrgA; Provisional; Region: PRK15323 423368008873 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 423368008874 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 423368008875 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 423368008876 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 423368008877 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 423368008878 transcriptional regulator HilD; Provisional; Region: PRK15185 423368008879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368008880 invasion protein regulator; Provisional; Region: PRK12370 423368008881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368008882 DNA binding site [nucleotide binding] 423368008883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 423368008884 binding surface 423368008885 TPR motif; other site 423368008886 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 423368008887 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368008888 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368008889 catalytic residue [active] 423368008890 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 423368008891 SicP binding; Region: SicP-binding; pfam09119 423368008892 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 423368008893 switch II binding region; other site 423368008894 Rac1 P-loop interaction site [polypeptide binding]; other site 423368008895 GTP binding residues [chemical binding]; other site 423368008896 switch I binding region; other site 423368008897 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 423368008898 active site 423368008899 chaperone protein SicP; Provisional; Region: PRK15329 423368008900 putative acyl carrier protein IacP; Validated; Region: PRK08172 423368008901 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 423368008902 cell invasion protein SipD; Provisional; Region: PRK15330 423368008903 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 423368008904 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 423368008905 chaperone protein SicA; Provisional; Region: PRK15331 423368008906 Tetratricopeptide repeat; Region: TPR_3; pfam07720 423368008907 Tetratricopeptide repeat; Region: TPR_3; pfam07720 423368008908 type III secretion system protein SpaS; Validated; Region: PRK08156 423368008909 type III secretion system protein SpaR; Provisional; Region: PRK15332 423368008910 type III secretion system protein SpaQ; Provisional; Region: PRK15333 423368008911 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 423368008912 type III secretion system protein SpaO; Validated; Region: PRK08158 423368008913 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 423368008914 antigen presentation protein SpaN; Provisional; Region: PRK15334 423368008915 Surface presentation of antigens protein; Region: SPAN; pfam02510 423368008916 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 423368008917 ATP synthase SpaL; Validated; Region: PRK08149 423368008918 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 423368008919 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 423368008920 Walker A motif; other site 423368008921 ATP binding site [chemical binding]; other site 423368008922 Walker B motif; other site 423368008923 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 423368008924 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 423368008925 type III secretion system protein InvA; Provisional; Region: PRK15337 423368008926 type III secretion system regulator InvE; Provisional; Region: PRK15338 423368008927 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 423368008928 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 423368008929 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 423368008930 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 423368008931 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 423368008932 transcriptional regulator InvF; Provisional; Region: PRK15340 423368008933 InvH outer membrane lipoprotein; Region: InvH; pfam04741 423368008934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 423368008935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 423368008936 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 423368008937 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 423368008938 active site 423368008939 metal binding site [ion binding]; metal-binding site 423368008940 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 423368008941 MutS domain I; Region: MutS_I; pfam01624 423368008942 MutS domain II; Region: MutS_II; pfam05188 423368008943 MutS domain III; Region: MutS_III; pfam05192 423368008944 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 423368008945 Walker A/P-loop; other site 423368008946 ATP binding site [chemical binding]; other site 423368008947 Q-loop/lid; other site 423368008948 ABC transporter signature motif; other site 423368008949 Walker B; other site 423368008950 D-loop; other site 423368008951 H-loop/switch region; other site 423368008952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 423368008953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368008954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 423368008955 putative substrate translocation pore; other site 423368008956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368008957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368008958 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 423368008959 putative effector binding pocket; other site 423368008960 dimerization interface [polypeptide binding]; other site 423368008961 GntP family permease; Region: GntP_permease; pfam02447 423368008962 fructuronate transporter; Provisional; Region: PRK10034; cl15264 423368008963 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 423368008964 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 423368008965 putative NAD(P) binding site [chemical binding]; other site 423368008966 active site 423368008967 putative substrate binding site [chemical binding]; other site 423368008968 hypothetical protein; Provisional; Region: PRK09989 423368008969 putative aldolase; Validated; Region: PRK08130 423368008970 intersubunit interface [polypeptide binding]; other site 423368008971 active site 423368008972 Zn2+ binding site [ion binding]; other site 423368008973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 423368008974 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 423368008975 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 423368008976 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368008977 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368008978 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368008979 MarR family; Region: MarR_2; cl17246 423368008980 Transcriptional regulators [Transcription]; Region: MarR; COG1846 423368008981 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 423368008982 Flavoprotein; Region: Flavoprotein; pfam02441 423368008983 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 423368008984 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 423368008985 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 423368008986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 423368008987 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 423368008988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 423368008989 DNA binding residues [nucleotide binding] 423368008990 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 423368008991 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368008992 Peptidase family M23; Region: Peptidase_M23; pfam01551 423368008993 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 423368008994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368008995 S-adenosylmethionine binding site [chemical binding]; other site 423368008996 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 423368008997 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 423368008998 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 423368008999 Permutation of conserved domain; other site 423368009000 active site 423368009001 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 423368009002 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 423368009003 homotrimer interaction site [polypeptide binding]; other site 423368009004 zinc binding site [ion binding]; other site 423368009005 CDP-binding sites; other site 423368009006 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 423368009007 substrate binding site; other site 423368009008 dimer interface; other site 423368009009 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 423368009010 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 423368009011 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 423368009012 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 423368009013 ligand-binding site [chemical binding]; other site 423368009014 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 423368009015 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 423368009016 CysD dimerization site [polypeptide binding]; other site 423368009017 G1 box; other site 423368009018 putative GEF interaction site [polypeptide binding]; other site 423368009019 GTP/Mg2+ binding site [chemical binding]; other site 423368009020 Switch I region; other site 423368009021 G2 box; other site 423368009022 G3 box; other site 423368009023 Switch II region; other site 423368009024 G4 box; other site 423368009025 G5 box; other site 423368009026 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 423368009027 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 423368009028 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 423368009029 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 423368009030 Active Sites [active] 423368009031 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 423368009032 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 423368009033 metal binding site [ion binding]; metal-binding site 423368009034 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 423368009035 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 423368009036 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 423368009037 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 423368009038 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 423368009039 CT1975-like protein; Region: Cas_CT1975; pfam09344 423368009040 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 423368009041 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 423368009042 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 423368009043 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 423368009044 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 423368009045 Active Sites [active] 423368009046 sulfite reductase subunit beta; Provisional; Region: PRK13504 423368009047 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 423368009048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 423368009049 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 423368009050 Flavodoxin; Region: Flavodoxin_1; pfam00258 423368009051 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 423368009052 FAD binding pocket [chemical binding]; other site 423368009053 FAD binding motif [chemical binding]; other site 423368009054 catalytic residues [active] 423368009055 NAD binding pocket [chemical binding]; other site 423368009056 phosphate binding motif [ion binding]; other site 423368009057 beta-alpha-beta structure motif; other site 423368009058 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 423368009059 active site 423368009060 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 423368009061 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 423368009062 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 423368009063 enolase; Provisional; Region: eno; PRK00077 423368009064 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 423368009065 dimer interface [polypeptide binding]; other site 423368009066 metal binding site [ion binding]; metal-binding site 423368009067 substrate binding pocket [chemical binding]; other site 423368009068 CTP synthetase; Validated; Region: pyrG; PRK05380 423368009069 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 423368009070 Catalytic site [active] 423368009071 active site 423368009072 UTP binding site [chemical binding]; other site 423368009073 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 423368009074 active site 423368009075 putative oxyanion hole; other site 423368009076 catalytic triad [active] 423368009077 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 423368009078 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 423368009079 homodimer interface [polypeptide binding]; other site 423368009080 metal binding site [ion binding]; metal-binding site 423368009081 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 423368009082 homodimer interface [polypeptide binding]; other site 423368009083 active site 423368009084 putative chemical substrate binding site [chemical binding]; other site 423368009085 metal binding site [ion binding]; metal-binding site 423368009086 fimbrial protein SteA; Provisional; Region: PRK15261 423368009087 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 423368009088 PapC N-terminal domain; Region: PapC_N; pfam13954 423368009089 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368009090 PapC C-terminal domain; Region: PapC_C; pfam13953 423368009091 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 423368009092 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368009093 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368009094 putative fimbrial protein SteD; Provisional; Region: PRK15275 423368009095 putative fimbrial subunit SteE; Provisional; Region: PRK15276 423368009096 fimbrial protein SteF; Provisional; Region: PRK15260 423368009097 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 423368009098 HD domain; Region: HD_4; pfam13328 423368009099 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 423368009100 synthetase active site [active] 423368009101 NTP binding site [chemical binding]; other site 423368009102 metal binding site [ion binding]; metal-binding site 423368009103 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 423368009104 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 423368009105 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 423368009106 TRAM domain; Region: TRAM; pfam01938 423368009107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368009108 S-adenosylmethionine binding site [chemical binding]; other site 423368009109 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 423368009110 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 423368009111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368009112 dimerization interface [polypeptide binding]; other site 423368009113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368009114 dimer interface [polypeptide binding]; other site 423368009115 phosphorylation site [posttranslational modification] 423368009116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368009117 ATP binding site [chemical binding]; other site 423368009118 Mg2+ binding site [ion binding]; other site 423368009119 G-X-G motif; other site 423368009120 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 423368009121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368009122 active site 423368009123 phosphorylation site [posttranslational modification] 423368009124 intermolecular recognition site; other site 423368009125 dimerization interface [polypeptide binding]; other site 423368009126 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 423368009127 putative binding surface; other site 423368009128 active site 423368009129 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 423368009130 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 423368009131 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 423368009132 active site 423368009133 tetramer interface [polypeptide binding]; other site 423368009134 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 423368009135 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 423368009136 active site 423368009137 tetramer interface [polypeptide binding]; other site 423368009138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009139 D-galactonate transporter; Region: 2A0114; TIGR00893 423368009140 putative substrate translocation pore; other site 423368009141 flavodoxin; Provisional; Region: PRK08105 423368009142 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 423368009143 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 423368009144 probable active site [active] 423368009145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 423368009146 SecY interacting protein Syd; Provisional; Region: PRK04968 423368009147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 423368009148 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 423368009149 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 423368009150 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 423368009151 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 423368009152 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 423368009153 serine transporter; Region: stp; TIGR00814 423368009154 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 423368009155 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 423368009156 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 423368009157 flap endonuclease-like protein; Provisional; Region: PRK09482 423368009158 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 423368009159 active site 423368009160 metal binding site 1 [ion binding]; metal-binding site 423368009161 putative 5' ssDNA interaction site; other site 423368009162 metal binding site 3; metal-binding site 423368009163 metal binding site 2 [ion binding]; metal-binding site 423368009164 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 423368009165 putative DNA binding site [nucleotide binding]; other site 423368009166 putative metal binding site [ion binding]; other site 423368009167 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 423368009168 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 423368009169 dimer interface [polypeptide binding]; other site 423368009170 active site 423368009171 metal binding site [ion binding]; metal-binding site 423368009172 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 423368009173 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 423368009174 intersubunit interface [polypeptide binding]; other site 423368009175 active site 423368009176 Zn2+ binding site [ion binding]; other site 423368009177 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 423368009178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009179 putative substrate translocation pore; other site 423368009180 L-fucose isomerase; Provisional; Region: fucI; PRK10991 423368009181 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 423368009182 hexamer (dimer of trimers) interface [polypeptide binding]; other site 423368009183 trimer interface [polypeptide binding]; other site 423368009184 substrate binding site [chemical binding]; other site 423368009185 Mn binding site [ion binding]; other site 423368009186 L-fuculokinase; Provisional; Region: PRK10331 423368009187 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 423368009188 nucleotide binding site [chemical binding]; other site 423368009189 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 423368009190 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 423368009191 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 423368009192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368009193 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 423368009194 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 423368009195 hypothetical protein; Provisional; Region: PRK10873 423368009196 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 423368009197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009198 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 423368009199 dimerization interface [polypeptide binding]; other site 423368009200 substrate binding pocket [chemical binding]; other site 423368009201 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 423368009202 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 423368009203 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 423368009204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368009205 catalytic residue [active] 423368009206 CsdA-binding activator; Provisional; Region: PRK15019 423368009207 Predicted permeases [General function prediction only]; Region: RarD; COG2962 423368009208 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 423368009209 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 423368009210 putative ATP binding site [chemical binding]; other site 423368009211 putative substrate interface [chemical binding]; other site 423368009212 murein transglycosylase A; Provisional; Region: mltA; PRK11162 423368009213 murein hydrolase B; Provisional; Region: PRK10760; cl17906 423368009214 MltA specific insert domain; Region: MltA; pfam03562 423368009215 3D domain; Region: 3D; pfam06725 423368009216 AMIN domain; Region: AMIN; pfam11741 423368009217 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 423368009218 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 423368009219 active site 423368009220 metal binding site [ion binding]; metal-binding site 423368009221 N-acetylglutamate synthase; Validated; Region: PRK05279 423368009222 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 423368009223 putative feedback inhibition sensing region; other site 423368009224 putative nucleotide binding site [chemical binding]; other site 423368009225 putative substrate binding site [chemical binding]; other site 423368009226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368009227 Coenzyme A binding pocket [chemical binding]; other site 423368009228 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 423368009229 AAA domain; Region: AAA_30; pfam13604 423368009230 Family description; Region: UvrD_C_2; pfam13538 423368009231 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 423368009232 protease3; Provisional; Region: PRK15101 423368009233 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 423368009234 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 423368009235 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 423368009236 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 423368009237 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 423368009238 hypothetical protein; Provisional; Region: PRK10332 423368009239 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 423368009240 hypothetical protein; Provisional; Region: PRK11521 423368009241 hypothetical protein; Provisional; Region: PRK10557 423368009242 hypothetical protein; Provisional; Region: PRK10506 423368009243 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 423368009244 thymidylate synthase; Reviewed; Region: thyA; PRK01827 423368009245 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 423368009246 dimerization interface [polypeptide binding]; other site 423368009247 active site 423368009248 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 423368009249 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 423368009250 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 423368009251 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 423368009252 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 423368009253 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 423368009254 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 423368009255 putative active site [active] 423368009256 Ap4A binding site [chemical binding]; other site 423368009257 nudix motif; other site 423368009258 putative metal binding site [ion binding]; other site 423368009259 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 423368009260 putative DNA-binding cleft [nucleotide binding]; other site 423368009261 putative DNA clevage site; other site 423368009262 molecular lever; other site 423368009263 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 423368009264 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 423368009265 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368009266 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368009267 active site 423368009268 catalytic tetrad [active] 423368009269 lysophospholipid transporter LplT; Provisional; Region: PRK11195 423368009270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009271 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 423368009272 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 423368009273 putative acyl-acceptor binding pocket; other site 423368009274 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 423368009275 acyl-activating enzyme (AAE) consensus motif; other site 423368009276 putative AMP binding site [chemical binding]; other site 423368009277 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 423368009278 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368009279 DNA binding site [nucleotide binding] 423368009280 domain linker motif; other site 423368009281 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 423368009282 dimerization interface (closed form) [polypeptide binding]; other site 423368009283 ligand binding site [chemical binding]; other site 423368009284 Transcriptional regulators [Transcription]; Region: PurR; COG1609 423368009285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368009286 DNA binding site [nucleotide binding] 423368009287 domain linker motif; other site 423368009288 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 423368009289 dimerization interface (closed form) [polypeptide binding]; other site 423368009290 ligand binding site [chemical binding]; other site 423368009291 diaminopimelate decarboxylase; Provisional; Region: PRK11165 423368009292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 423368009293 active site 423368009294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368009295 substrate binding site [chemical binding]; other site 423368009296 catalytic residues [active] 423368009297 dimer interface [polypeptide binding]; other site 423368009298 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 423368009299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368009301 dimerization interface [polypeptide binding]; other site 423368009302 putative racemase; Provisional; Region: PRK10200 423368009303 aspartate racemase; Region: asp_race; TIGR00035 423368009304 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 423368009305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009306 putative substrate translocation pore; other site 423368009307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009308 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 423368009309 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 423368009310 NADP binding site [chemical binding]; other site 423368009311 homodimer interface [polypeptide binding]; other site 423368009312 active site 423368009313 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 423368009314 putative acyltransferase; Provisional; Region: PRK05790 423368009315 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 423368009316 dimer interface [polypeptide binding]; other site 423368009317 active site 423368009318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368009319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368009321 dimerization interface [polypeptide binding]; other site 423368009322 Predicted membrane protein [Function unknown]; Region: COG4125 423368009323 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 423368009324 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 423368009325 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 423368009326 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 423368009327 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 423368009328 putative metal binding site [ion binding]; other site 423368009329 putative homodimer interface [polypeptide binding]; other site 423368009330 putative homotetramer interface [polypeptide binding]; other site 423368009331 putative homodimer-homodimer interface [polypeptide binding]; other site 423368009332 putative allosteric switch controlling residues; other site 423368009333 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 423368009334 transcriptional activator SprB; Provisional; Region: PRK15320 423368009335 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 423368009336 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 423368009337 Fimbrial protein; Region: Fimbrial; pfam00419 423368009338 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 423368009339 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368009340 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368009341 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 423368009342 PapC N-terminal domain; Region: PapC_N; pfam13954 423368009343 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368009344 PapC C-terminal domain; Region: PapC_C; pfam13953 423368009345 fimbrial protein StdA; Provisional; Region: PRK15210 423368009346 hypothetical protein; Provisional; Region: PRK10316 423368009347 YfdX protein; Region: YfdX; pfam10938 423368009348 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 423368009349 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 423368009350 oligomeric interface; other site 423368009351 putative active site [active] 423368009352 homodimer interface [polypeptide binding]; other site 423368009353 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 423368009354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 423368009355 Peptidase family M23; Region: Peptidase_M23; pfam01551 423368009356 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 423368009357 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 423368009358 active site 423368009359 metal binding site [ion binding]; metal-binding site 423368009360 nudix motif; other site 423368009361 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 423368009362 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 423368009363 dimer interface [polypeptide binding]; other site 423368009364 putative anticodon binding site; other site 423368009365 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 423368009366 motif 1; other site 423368009367 active site 423368009368 motif 2; other site 423368009369 motif 3; other site 423368009370 This domain is found in peptide chain release factors; Region: PCRF; smart00937 423368009371 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 423368009372 RF-1 domain; Region: RF-1; pfam00472 423368009373 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 423368009374 DHH family; Region: DHH; pfam01368 423368009375 DHHA1 domain; Region: DHHA1; pfam02272 423368009376 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 423368009377 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 423368009378 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 423368009379 dimerization domain [polypeptide binding]; other site 423368009380 dimer interface [polypeptide binding]; other site 423368009381 catalytic residues [active] 423368009382 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 423368009383 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 423368009384 active site 423368009385 Int/Topo IB signature motif; other site 423368009386 flavodoxin FldB; Provisional; Region: PRK12359 423368009387 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 423368009388 hypothetical protein; Provisional; Region: PRK10878 423368009389 putative global regulator; Reviewed; Region: PRK09559 423368009390 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 423368009391 hemolysin; Provisional; Region: PRK15087 423368009392 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 423368009393 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 423368009394 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 423368009395 beta-galactosidase; Region: BGL; TIGR03356 423368009396 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 423368009397 glycine dehydrogenase; Provisional; Region: PRK05367 423368009398 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 423368009399 tetramer interface [polypeptide binding]; other site 423368009400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368009401 catalytic residue [active] 423368009402 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 423368009403 tetramer interface [polypeptide binding]; other site 423368009404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368009405 catalytic residue [active] 423368009406 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 423368009407 lipoyl attachment site [posttranslational modification]; other site 423368009408 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 423368009409 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 423368009410 oxidoreductase; Provisional; Region: PRK08013 423368009411 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 423368009412 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 423368009413 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 423368009414 proline aminopeptidase P II; Provisional; Region: PRK10879 423368009415 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 423368009416 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 423368009417 active site 423368009418 hypothetical protein; Reviewed; Region: PRK01736 423368009419 Z-ring-associated protein; Provisional; Region: PRK10972 423368009420 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 423368009421 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 423368009422 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 423368009423 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 423368009424 ligand binding site [chemical binding]; other site 423368009425 NAD binding site [chemical binding]; other site 423368009426 tetramer interface [polypeptide binding]; other site 423368009427 catalytic site [active] 423368009428 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 423368009429 L-serine binding site [chemical binding]; other site 423368009430 ACT domain interface; other site 423368009431 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 423368009432 tetramer (dimer of dimers) interface [polypeptide binding]; other site 423368009433 active site 423368009434 dimer interface [polypeptide binding]; other site 423368009435 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 423368009436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009437 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 423368009438 putative dimerization interface [polypeptide binding]; other site 423368009439 Uncharacterized conserved protein [Function unknown]; Region: COG2968 423368009440 oxidative stress defense protein; Provisional; Region: PRK11087 423368009441 arginine exporter protein; Provisional; Region: PRK09304 423368009442 mechanosensitive channel MscS; Provisional; Region: PRK10334 423368009443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368009444 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 423368009445 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 423368009446 active site 423368009447 intersubunit interface [polypeptide binding]; other site 423368009448 zinc binding site [ion binding]; other site 423368009449 Na+ binding site [ion binding]; other site 423368009450 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 423368009451 Phosphoglycerate kinase; Region: PGK; pfam00162 423368009452 substrate binding site [chemical binding]; other site 423368009453 hinge regions; other site 423368009454 ADP binding site [chemical binding]; other site 423368009455 catalytic site [active] 423368009456 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 423368009457 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 423368009458 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 423368009459 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 423368009460 trimer interface [polypeptide binding]; other site 423368009461 putative Zn binding site [ion binding]; other site 423368009462 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 423368009463 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 423368009464 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 423368009465 Walker A/P-loop; other site 423368009466 ATP binding site [chemical binding]; other site 423368009467 Q-loop/lid; other site 423368009468 ABC transporter signature motif; other site 423368009469 Walker B; other site 423368009470 D-loop; other site 423368009471 H-loop/switch region; other site 423368009472 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 423368009473 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 423368009474 Walker A/P-loop; other site 423368009475 ATP binding site [chemical binding]; other site 423368009476 Q-loop/lid; other site 423368009477 ABC transporter signature motif; other site 423368009478 Walker B; other site 423368009479 D-loop; other site 423368009480 H-loop/switch region; other site 423368009481 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 423368009482 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 423368009483 active site 423368009484 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 423368009485 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 423368009486 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 423368009487 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 423368009488 putative active site [active] 423368009489 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 423368009490 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 423368009491 putative NAD(P) binding site [chemical binding]; other site 423368009492 catalytic Zn binding site [ion binding]; other site 423368009493 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 423368009494 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 423368009495 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 423368009496 active site 423368009497 P-loop; other site 423368009498 phosphorylation site [posttranslational modification] 423368009499 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368009500 active site 423368009501 phosphorylation site [posttranslational modification] 423368009502 transketolase; Reviewed; Region: PRK12753 423368009503 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 423368009504 TPP-binding site [chemical binding]; other site 423368009505 dimer interface [polypeptide binding]; other site 423368009506 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 423368009507 PYR/PP interface [polypeptide binding]; other site 423368009508 dimer interface [polypeptide binding]; other site 423368009509 TPP binding site [chemical binding]; other site 423368009510 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 423368009511 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 423368009512 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 423368009513 agmatinase; Region: agmatinase; TIGR01230 423368009514 oligomer interface [polypeptide binding]; other site 423368009515 putative active site [active] 423368009516 Mn binding site [ion binding]; other site 423368009517 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 423368009518 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 423368009519 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 423368009520 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 423368009521 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 423368009522 putative NAD(P) binding site [chemical binding]; other site 423368009523 catalytic Zn binding site [ion binding]; other site 423368009524 structural Zn binding site [ion binding]; other site 423368009525 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 423368009526 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 423368009527 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 423368009528 Transcriptional regulators [Transcription]; Region: FadR; COG2186 423368009529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368009530 DNA-binding site [nucleotide binding]; DNA binding site 423368009531 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 423368009532 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 423368009533 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 423368009534 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 423368009535 dimer interface [polypeptide binding]; other site 423368009536 active site 423368009537 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368009538 catalytic residues [active] 423368009539 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 423368009540 Virulence promoting factor; Region: YqgB; pfam11036 423368009541 S-adenosylmethionine synthetase; Validated; Region: PRK05250 423368009542 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 423368009543 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 423368009544 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 423368009545 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 423368009546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009547 putative substrate translocation pore; other site 423368009548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009549 hypothetical protein; Provisional; Region: PRK04860 423368009550 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 423368009551 DNA-specific endonuclease I; Provisional; Region: PRK15137 423368009552 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 423368009553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 423368009554 RNA methyltransferase, RsmE family; Region: TIGR00046 423368009555 glutathione synthetase; Provisional; Region: PRK05246 423368009556 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 423368009557 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 423368009558 hypothetical protein; Validated; Region: PRK00228 423368009559 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 423368009560 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 423368009561 Transcriptional regulator [Transcription]; Region: IclR; COG1414 423368009562 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 423368009563 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 423368009564 Walker A motif; other site 423368009565 ATP binding site [chemical binding]; other site 423368009566 Walker B motif; other site 423368009567 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 423368009568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368009569 catalytic residue [active] 423368009570 YGGT family; Region: YGGT; pfam02325 423368009571 YGGT family; Region: YGGT; pfam02325 423368009572 hypothetical protein; Validated; Region: PRK05090 423368009573 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 423368009574 active site 423368009575 dimerization interface [polypeptide binding]; other site 423368009576 HemN family oxidoreductase; Provisional; Region: PRK05660 423368009577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368009578 FeS/SAM binding site; other site 423368009579 HemN C-terminal domain; Region: HemN_C; pfam06969 423368009580 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 423368009581 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 423368009582 homodimer interface [polypeptide binding]; other site 423368009583 active site 423368009584 hypothetical protein; Provisional; Region: PRK10626 423368009585 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 423368009586 hypothetical protein; Provisional; Region: PRK11702 423368009587 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 423368009588 adenine DNA glycosylase; Provisional; Region: PRK10880 423368009589 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 423368009590 minor groove reading motif; other site 423368009591 helix-hairpin-helix signature motif; other site 423368009592 substrate binding pocket [chemical binding]; other site 423368009593 active site 423368009594 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 423368009595 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 423368009596 DNA binding and oxoG recognition site [nucleotide binding] 423368009597 oxidative damage protection protein; Provisional; Region: PRK05408 423368009598 murein transglycosylase C; Provisional; Region: mltC; PRK11671 423368009599 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 423368009600 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368009601 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368009602 catalytic residue [active] 423368009603 nucleoside transporter; Region: 2A0110; TIGR00889 423368009604 ornithine decarboxylase; Provisional; Region: PRK13578 423368009605 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 423368009606 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 423368009607 homodimer interface [polypeptide binding]; other site 423368009608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368009609 catalytic residue [active] 423368009610 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 423368009611 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 423368009612 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 423368009613 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 423368009614 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 423368009615 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 423368009616 putative active site [active] 423368009617 putative catalytic site [active] 423368009618 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 423368009619 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 423368009620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009621 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 423368009622 putative dimerization interface [polypeptide binding]; other site 423368009623 putative substrate binding pocket [chemical binding]; other site 423368009624 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 423368009625 Sulfatase; Region: Sulfatase; pfam00884 423368009626 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 423368009627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368009628 FeS/SAM binding site; other site 423368009629 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 423368009630 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 423368009631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368009632 DNA binding residues [nucleotide binding] 423368009633 dimerization interface [polypeptide binding]; other site 423368009634 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 423368009635 Amino acid permease; Region: AA_permease_2; pfam13520 423368009636 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 423368009637 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 423368009638 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 423368009639 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 423368009640 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 423368009641 NAD(P) binding site [chemical binding]; other site 423368009642 catalytic residues [active] 423368009643 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 423368009644 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 423368009645 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 423368009646 active site 423368009647 catalytic site [active] 423368009648 Zn binding site [ion binding]; other site 423368009649 tetramer interface [polypeptide binding]; other site 423368009650 Predicted amidohydrolase [General function prediction only]; Region: COG0388 423368009651 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 423368009652 putative active site [active] 423368009653 catalytic triad [active] 423368009654 putative dimer interface [polypeptide binding]; other site 423368009655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368009656 D-galactonate transporter; Region: 2A0114; TIGR00893 423368009657 putative substrate translocation pore; other site 423368009658 mannonate dehydratase; Provisional; Region: PRK03906 423368009659 mannonate dehydratase; Region: uxuA; TIGR00695 423368009660 D-mannonate oxidoreductase; Provisional; Region: PRK15037 423368009661 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 423368009662 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 423368009663 Glucuronate isomerase; Region: UxaC; pfam02614 423368009664 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 423368009665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368009666 dimer interface [polypeptide binding]; other site 423368009667 putative CheW interface [polypeptide binding]; other site 423368009668 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 423368009669 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 423368009670 CHAP domain; Region: CHAP; pfam05257 423368009671 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 423368009672 putative S-transferase; Provisional; Region: PRK11752 423368009673 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 423368009674 C-terminal domain interface [polypeptide binding]; other site 423368009675 GSH binding site (G-site) [chemical binding]; other site 423368009676 dimer interface [polypeptide binding]; other site 423368009677 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 423368009678 dimer interface [polypeptide binding]; other site 423368009679 N-terminal domain interface [polypeptide binding]; other site 423368009680 active site 423368009681 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 423368009682 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 423368009683 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 423368009684 putative ligand binding residues [chemical binding]; other site 423368009685 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 423368009686 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 423368009687 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 423368009688 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 423368009689 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 423368009690 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 423368009691 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 423368009692 putative substrate-binding site; other site 423368009693 nickel binding site [ion binding]; other site 423368009694 hydrogenase 2 large subunit; Provisional; Region: PRK10467 423368009695 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 423368009696 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 423368009697 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 423368009698 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 423368009699 4Fe-4S binding domain; Region: Fer4_6; pfam12837 423368009700 hydrogenase 2 small subunit; Provisional; Region: PRK10468 423368009701 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 423368009702 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 423368009703 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 423368009704 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 423368009705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368009706 dimerization interface [polypeptide binding]; other site 423368009707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368009708 dimer interface [polypeptide binding]; other site 423368009709 putative CheW interface [polypeptide binding]; other site 423368009710 hypothetical protein; Provisional; Region: PRK05208 423368009711 oxidoreductase; Provisional; Region: PRK07985 423368009712 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 423368009713 NAD binding site [chemical binding]; other site 423368009714 metal binding site [ion binding]; metal-binding site 423368009715 active site 423368009716 biopolymer transport protein ExbD; Provisional; Region: PRK11267 423368009717 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 423368009718 biopolymer transport protein ExbB; Provisional; Region: PRK10414 423368009719 cystathionine beta-lyase; Provisional; Region: PRK08114 423368009720 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 423368009721 homodimer interface [polypeptide binding]; other site 423368009722 substrate-cofactor binding pocket; other site 423368009723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368009724 catalytic residue [active] 423368009725 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 423368009726 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 423368009727 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 423368009728 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 423368009729 dimer interface [polypeptide binding]; other site 423368009730 active site 423368009731 metal binding site [ion binding]; metal-binding site 423368009732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 423368009733 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 423368009734 active site 423368009735 catalytic tetrad [active] 423368009736 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 423368009737 nucleotide binding site/active site [active] 423368009738 catalytic residue [active] 423368009739 hypothetical protein; Provisional; Region: PRK01254 423368009740 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 423368009741 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 423368009742 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 423368009743 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 423368009744 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 423368009745 DctM-like transporters; Region: DctM; pfam06808 423368009746 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 423368009747 FtsI repressor; Provisional; Region: PRK10883 423368009748 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 423368009749 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 423368009750 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 423368009751 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 423368009752 putative acyl-acceptor binding pocket; other site 423368009753 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 423368009754 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 423368009755 CAP-like domain; other site 423368009756 active site 423368009757 primary dimer interface [polypeptide binding]; other site 423368009758 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 423368009759 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368009760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368009761 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 423368009762 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 423368009763 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 423368009764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368009765 active site 423368009766 phosphorylation site [posttranslational modification] 423368009767 intermolecular recognition site; other site 423368009768 dimerization interface [polypeptide binding]; other site 423368009769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368009770 DNA binding site [nucleotide binding] 423368009771 sensor protein QseC; Provisional; Region: PRK10337 423368009772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368009773 dimer interface [polypeptide binding]; other site 423368009774 phosphorylation site [posttranslational modification] 423368009775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368009776 ATP binding site [chemical binding]; other site 423368009777 Mg2+ binding site [ion binding]; other site 423368009778 G-X-G motif; other site 423368009779 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 423368009780 Uncharacterized conserved protein [Function unknown]; Region: COG1359 423368009781 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 423368009782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368009783 ATP binding site [chemical binding]; other site 423368009784 Mg2+ binding site [ion binding]; other site 423368009785 G-X-G motif; other site 423368009786 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 423368009787 anchoring element; other site 423368009788 dimer interface [polypeptide binding]; other site 423368009789 ATP binding site [chemical binding]; other site 423368009790 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 423368009791 active site 423368009792 metal binding site [ion binding]; metal-binding site 423368009793 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 423368009794 esterase YqiA; Provisional; Region: PRK11071 423368009795 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 423368009796 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 423368009797 active site 423368009798 metal binding site [ion binding]; metal-binding site 423368009799 hexamer interface [polypeptide binding]; other site 423368009800 putative dehydrogenase; Provisional; Region: PRK11039 423368009801 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 423368009802 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 423368009803 dimer interface [polypeptide binding]; other site 423368009804 ADP-ribose binding site [chemical binding]; other site 423368009805 active site 423368009806 nudix motif; other site 423368009807 metal binding site [ion binding]; metal-binding site 423368009808 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 423368009809 hypothetical protein; Provisional; Region: PRK11653 423368009810 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 423368009811 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 423368009812 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 423368009813 putative active site [active] 423368009814 metal binding site [ion binding]; metal-binding site 423368009815 zinc transporter ZupT; Provisional; Region: PRK04201 423368009816 ZIP Zinc transporter; Region: Zip; pfam02535 423368009817 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 423368009818 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 423368009819 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 423368009820 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 423368009821 catalytic residues [active] 423368009822 hinge region; other site 423368009823 alpha helical domain; other site 423368009824 putative disulfide oxidoreductase; Provisional; Region: PRK04307 423368009825 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 423368009826 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 423368009827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 423368009828 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 423368009829 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 423368009830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 423368009831 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 423368009832 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 423368009833 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 423368009834 putative ribose interaction site [chemical binding]; other site 423368009835 putative ADP binding site [chemical binding]; other site 423368009836 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 423368009837 active site 423368009838 nucleotide binding site [chemical binding]; other site 423368009839 HIGH motif; other site 423368009840 KMSKS motif; other site 423368009841 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 423368009842 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 423368009843 metal binding triad; other site 423368009844 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 423368009845 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 423368009846 metal binding triad; other site 423368009847 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 423368009848 Uncharacterized conserved protein [Function unknown]; Region: COG3025 423368009849 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 423368009850 putative active site [active] 423368009851 putative metal binding residues [ion binding]; other site 423368009852 signature motif; other site 423368009853 putative triphosphate binding site [ion binding]; other site 423368009854 CHAD domain; Region: CHAD; pfam05235 423368009855 SH3 domain-containing protein; Provisional; Region: PRK10884 423368009856 Bacterial SH3 domain homologues; Region: SH3b; smart00287 423368009857 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 423368009858 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 423368009859 active site 423368009860 NTP binding site [chemical binding]; other site 423368009861 metal binding triad [ion binding]; metal-binding site 423368009862 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 423368009863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 423368009864 Zn2+ binding site [ion binding]; other site 423368009865 Mg2+ binding site [ion binding]; other site 423368009866 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 423368009867 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 423368009868 homooctamer interface [polypeptide binding]; other site 423368009869 active site 423368009870 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 423368009871 UGMP family protein; Validated; Region: PRK09604 423368009872 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 423368009873 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 423368009874 DNA primase; Validated; Region: dnaG; PRK05667 423368009875 CHC2 zinc finger; Region: zf-CHC2; pfam01807 423368009876 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 423368009877 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 423368009878 active site 423368009879 metal binding site [ion binding]; metal-binding site 423368009880 interdomain interaction site; other site 423368009881 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 423368009882 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 423368009883 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 423368009884 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 423368009885 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 423368009886 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 423368009887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 423368009888 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 423368009889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 423368009890 DNA binding residues [nucleotide binding] 423368009891 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 423368009892 active site 423368009893 SUMO-1 interface [polypeptide binding]; other site 423368009894 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 423368009895 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 423368009896 FAD binding pocket [chemical binding]; other site 423368009897 FAD binding motif [chemical binding]; other site 423368009898 phosphate binding motif [ion binding]; other site 423368009899 NAD binding pocket [chemical binding]; other site 423368009900 Predicted transcriptional regulators [Transcription]; Region: COG1695 423368009901 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 423368009902 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 423368009903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368009904 dimerization interface [polypeptide binding]; other site 423368009905 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 423368009906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368009907 dimer interface [polypeptide binding]; other site 423368009908 putative CheW interface [polypeptide binding]; other site 423368009909 PAS fold; Region: PAS_3; pfam08447 423368009910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368009911 putative active site [active] 423368009912 heme pocket [chemical binding]; other site 423368009913 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 423368009914 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368009915 dimer interface [polypeptide binding]; other site 423368009916 putative CheW interface [polypeptide binding]; other site 423368009917 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 423368009918 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 423368009919 inhibitor-cofactor binding pocket; inhibition site 423368009920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368009921 catalytic residue [active] 423368009922 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 423368009923 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 423368009924 active site 423368009925 FMN binding site [chemical binding]; other site 423368009926 2,4-decadienoyl-CoA binding site; other site 423368009927 catalytic residue [active] 423368009928 4Fe-4S cluster binding site [ion binding]; other site 423368009929 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 423368009930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368009931 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 423368009932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368009933 S-adenosylmethionine binding site [chemical binding]; other site 423368009934 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 423368009935 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 423368009936 putative active site [active] 423368009937 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 423368009938 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 423368009939 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 423368009940 serine/threonine transporter SstT; Provisional; Region: PRK13628 423368009941 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 423368009942 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 423368009943 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 423368009944 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 423368009945 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 423368009946 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 423368009947 Predicted membrane protein [Function unknown]; Region: COG5393 423368009948 YqjK-like protein; Region: YqjK; pfam13997 423368009949 Predicted membrane protein [Function unknown]; Region: COG2259 423368009950 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 423368009951 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 423368009952 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 423368009953 putative dimer interface [polypeptide binding]; other site 423368009954 N-terminal domain interface [polypeptide binding]; other site 423368009955 putative substrate binding pocket (H-site) [chemical binding]; other site 423368009956 Predicted membrane protein [Function unknown]; Region: COG3152 423368009957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009958 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 423368009959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368009960 dimerization interface [polypeptide binding]; other site 423368009961 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 423368009962 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 423368009963 serine transporter; Region: stp; TIGR00814 423368009964 L-serine dehydratase TdcG; Provisional; Region: PRK15040 423368009965 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 423368009966 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 423368009967 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 423368009968 Pyruvate formate lyase 1; Region: PFL1; cd01678 423368009969 coenzyme A binding site [chemical binding]; other site 423368009970 active site 423368009971 catalytic residues [active] 423368009972 glycine loop; other site 423368009973 propionate/acetate kinase; Provisional; Region: PRK12379 423368009974 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 423368009975 threonine/serine transporter TdcC; Provisional; Region: PRK13629 423368009976 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 423368009977 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 423368009978 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 423368009979 tetramer interface [polypeptide binding]; other site 423368009980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368009981 catalytic residue [active] 423368009982 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 423368009983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368009984 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 423368009985 putative substrate binding pocket [chemical binding]; other site 423368009986 putative dimerization interface [polypeptide binding]; other site 423368009987 glycerate kinase I; Provisional; Region: PRK10342 423368009988 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 423368009989 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 423368009990 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 423368009991 galactarate dehydratase; Region: galactar-dH20; TIGR03248 423368009992 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 423368009993 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 423368009994 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 423368009995 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 423368009996 intersubunit interface [polypeptide binding]; other site 423368009997 active site 423368009998 zinc binding site [ion binding]; other site 423368009999 Na+ binding site [ion binding]; other site 423368010000 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 423368010001 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368010002 active site 423368010003 phosphorylation site [posttranslational modification] 423368010004 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 423368010005 active site 423368010006 P-loop; other site 423368010007 phosphorylation site [posttranslational modification] 423368010008 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 423368010009 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 423368010010 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 423368010011 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 423368010012 putative NAD(P) binding site [chemical binding]; other site 423368010013 catalytic Zn binding site [ion binding]; other site 423368010014 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368010015 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368010016 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368010017 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 423368010018 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 423368010019 putative SAM binding site [chemical binding]; other site 423368010020 putative homodimer interface [polypeptide binding]; other site 423368010021 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 423368010022 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 423368010023 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 423368010024 putative ligand binding site [chemical binding]; other site 423368010025 TIGR00252 family protein; Region: TIGR00252 423368010026 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 423368010027 dimer interface [polypeptide binding]; other site 423368010028 active site 423368010029 outer membrane lipoprotein; Provisional; Region: PRK11023 423368010030 BON domain; Region: BON; pfam04972 423368010031 BON domain; Region: BON; pfam04972 423368010032 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 423368010033 NADH(P)-binding; Region: NAD_binding_10; pfam13460 423368010034 NAD binding site [chemical binding]; other site 423368010035 active site 423368010036 intracellular protease, PfpI family; Region: PfpI; TIGR01382 423368010037 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 423368010038 proposed catalytic triad [active] 423368010039 conserved cys residue [active] 423368010040 hypothetical protein; Provisional; Region: PRK03467 423368010041 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 423368010042 GIY-YIG motif/motif A; other site 423368010043 putative active site [active] 423368010044 putative metal binding site [ion binding]; other site 423368010045 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 423368010046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368010047 Coenzyme A binding pocket [chemical binding]; other site 423368010048 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 423368010049 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 423368010050 Peptidase family U32; Region: Peptidase_U32; pfam01136 423368010051 putative protease; Provisional; Region: PRK15447 423368010052 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 423368010053 hypothetical protein; Provisional; Region: PRK10508 423368010054 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 423368010055 tryptophan permease; Provisional; Region: PRK10483 423368010056 aromatic amino acid transport protein; Region: araaP; TIGR00837 423368010057 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 423368010058 DEAD-like helicases superfamily; Region: DEXDc; smart00487 423368010059 ATP binding site [chemical binding]; other site 423368010060 Mg++ binding site [ion binding]; other site 423368010061 motif III; other site 423368010062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368010063 nucleotide binding region [chemical binding]; other site 423368010064 ATP-binding site [chemical binding]; other site 423368010065 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 423368010066 putative RNA binding site [nucleotide binding]; other site 423368010067 lipoprotein NlpI; Provisional; Region: PRK11189 423368010068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 423368010069 binding surface 423368010070 TPR motif; other site 423368010071 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 423368010072 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 423368010073 RNase E interface [polypeptide binding]; other site 423368010074 trimer interface [polypeptide binding]; other site 423368010075 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 423368010076 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 423368010077 RNase E interface [polypeptide binding]; other site 423368010078 trimer interface [polypeptide binding]; other site 423368010079 active site 423368010080 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 423368010081 putative nucleic acid binding region [nucleotide binding]; other site 423368010082 G-X-X-G motif; other site 423368010083 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 423368010084 RNA binding site [nucleotide binding]; other site 423368010085 domain interface; other site 423368010086 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 423368010087 16S/18S rRNA binding site [nucleotide binding]; other site 423368010088 S13e-L30e interaction site [polypeptide binding]; other site 423368010089 25S rRNA binding site [nucleotide binding]; other site 423368010090 Ribosomal S15 leader 423368010091 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 423368010092 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 423368010093 RNA binding site [nucleotide binding]; other site 423368010094 active site 423368010095 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 423368010096 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 423368010097 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 423368010098 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 423368010099 translation initiation factor IF-2; Region: IF-2; TIGR00487 423368010100 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 423368010101 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 423368010102 G1 box; other site 423368010103 putative GEF interaction site [polypeptide binding]; other site 423368010104 GTP/Mg2+ binding site [chemical binding]; other site 423368010105 Switch I region; other site 423368010106 G2 box; other site 423368010107 G3 box; other site 423368010108 Switch II region; other site 423368010109 G4 box; other site 423368010110 G5 box; other site 423368010111 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 423368010112 Translation-initiation factor 2; Region: IF-2; pfam11987 423368010113 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 423368010114 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 423368010115 NusA N-terminal domain; Region: NusA_N; pfam08529 423368010116 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 423368010117 RNA binding site [nucleotide binding]; other site 423368010118 homodimer interface [polypeptide binding]; other site 423368010119 NusA-like KH domain; Region: KH_5; pfam13184 423368010120 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 423368010121 G-X-X-G motif; other site 423368010122 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 423368010123 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 423368010124 ribosome maturation protein RimP; Reviewed; Region: PRK00092 423368010125 Sm and related proteins; Region: Sm_like; cl00259 423368010126 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 423368010127 putative oligomer interface [polypeptide binding]; other site 423368010128 putative RNA binding site [nucleotide binding]; other site 423368010129 argininosuccinate synthase; Validated; Region: PRK05370 423368010130 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 423368010131 Preprotein translocase SecG subunit; Region: SecG; pfam03840 423368010132 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 423368010133 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 423368010134 active site 423368010135 substrate binding site [chemical binding]; other site 423368010136 metal binding site [ion binding]; metal-binding site 423368010137 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 423368010138 dihydropteroate synthase; Region: DHPS; TIGR01496 423368010139 substrate binding pocket [chemical binding]; other site 423368010140 dimer interface [polypeptide binding]; other site 423368010141 inhibitor binding site; inhibition site 423368010142 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 423368010143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368010144 Walker A motif; other site 423368010145 ATP binding site [chemical binding]; other site 423368010146 Walker B motif; other site 423368010147 arginine finger; other site 423368010148 Peptidase family M41; Region: Peptidase_M41; pfam01434 423368010149 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 423368010150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368010151 S-adenosylmethionine binding site [chemical binding]; other site 423368010152 RNA-binding protein YhbY; Provisional; Region: PRK10343 423368010153 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 423368010154 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 423368010155 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 423368010156 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 423368010157 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 423368010158 GTPase CgtA; Reviewed; Region: obgE; PRK12298 423368010159 GTP1/OBG; Region: GTP1_OBG; pfam01018 423368010160 Obg GTPase; Region: Obg; cd01898 423368010161 G1 box; other site 423368010162 GTP/Mg2+ binding site [chemical binding]; other site 423368010163 Switch I region; other site 423368010164 G2 box; other site 423368010165 G3 box; other site 423368010166 Switch II region; other site 423368010167 G4 box; other site 423368010168 G5 box; other site 423368010169 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 423368010170 EamA-like transporter family; Region: EamA; pfam00892 423368010171 EamA-like transporter family; Region: EamA; pfam00892 423368010172 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 423368010173 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 423368010174 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 423368010175 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 423368010176 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 423368010177 substrate binding pocket [chemical binding]; other site 423368010178 chain length determination region; other site 423368010179 substrate-Mg2+ binding site; other site 423368010180 catalytic residues [active] 423368010181 aspartate-rich region 1; other site 423368010182 active site lid residues [active] 423368010183 aspartate-rich region 2; other site 423368010184 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 423368010185 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 423368010186 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 423368010187 hinge; other site 423368010188 active site 423368010189 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 423368010190 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 423368010191 anti sigma factor interaction site; other site 423368010192 regulatory phosphorylation site [posttranslational modification]; other site 423368010193 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 423368010194 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 423368010195 mce related protein; Region: MCE; pfam02470 423368010196 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 423368010197 conserved hypothetical integral membrane protein; Region: TIGR00056 423368010198 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 423368010199 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 423368010200 Walker A/P-loop; other site 423368010201 ATP binding site [chemical binding]; other site 423368010202 Q-loop/lid; other site 423368010203 ABC transporter signature motif; other site 423368010204 Walker B; other site 423368010205 D-loop; other site 423368010206 H-loop/switch region; other site 423368010207 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 423368010208 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 423368010209 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 423368010210 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 423368010211 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 423368010212 putative active site [active] 423368010213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 423368010214 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 423368010215 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 423368010216 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 423368010217 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 423368010218 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 423368010219 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 423368010220 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 423368010221 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 423368010222 Walker A/P-loop; other site 423368010223 ATP binding site [chemical binding]; other site 423368010224 Q-loop/lid; other site 423368010225 ABC transporter signature motif; other site 423368010226 Walker B; other site 423368010227 D-loop; other site 423368010228 H-loop/switch region; other site 423368010229 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 423368010230 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 423368010231 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 423368010232 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 423368010233 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 423368010234 30S subunit binding site; other site 423368010235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368010236 active site 423368010237 phosphorylation site [posttranslational modification] 423368010238 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 423368010239 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 423368010240 dimerization domain swap beta strand [polypeptide binding]; other site 423368010241 regulatory protein interface [polypeptide binding]; other site 423368010242 active site 423368010243 regulatory phosphorylation site [posttranslational modification]; other site 423368010244 hypothetical protein; Provisional; Region: PRK10345 423368010245 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 423368010246 Transglycosylase; Region: Transgly; cl17702 423368010247 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 423368010248 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 423368010249 conserved cys residue [active] 423368010250 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 423368010251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368010252 putative active site [active] 423368010253 heme pocket [chemical binding]; other site 423368010254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368010255 dimer interface [polypeptide binding]; other site 423368010256 phosphorylation site [posttranslational modification] 423368010257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368010258 ATP binding site [chemical binding]; other site 423368010259 Mg2+ binding site [ion binding]; other site 423368010260 G-X-G motif; other site 423368010261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368010262 active site 423368010263 phosphorylation site [posttranslational modification] 423368010264 intermolecular recognition site; other site 423368010265 dimerization interface [polypeptide binding]; other site 423368010266 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 423368010267 putative binding surface; other site 423368010268 active site 423368010269 radical SAM protein, TIGR01212 family; Region: TIGR01212 423368010270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368010271 FeS/SAM binding site; other site 423368010272 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 423368010273 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 423368010274 active site 423368010275 dimer interface [polypeptide binding]; other site 423368010276 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 423368010277 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 423368010278 active site 423368010279 FMN binding site [chemical binding]; other site 423368010280 substrate binding site [chemical binding]; other site 423368010281 3Fe-4S cluster binding site [ion binding]; other site 423368010282 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 423368010283 domain interface; other site 423368010284 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 423368010285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368010286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368010287 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 423368010288 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 423368010289 Na binding site [ion binding]; other site 423368010290 putative substrate binding site [chemical binding]; other site 423368010291 cytosine deaminase; Provisional; Region: PRK09230 423368010292 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 423368010293 active site 423368010294 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 423368010295 N-acetylmannosamine kinase; Provisional; Region: PRK05082 423368010296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368010297 nucleotide binding site [chemical binding]; other site 423368010298 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 423368010299 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 423368010300 putative active site cavity [active] 423368010301 putative sialic acid transporter; Provisional; Region: PRK03893 423368010302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368010303 putative substrate translocation pore; other site 423368010304 N-acetylneuraminate lyase; Provisional; Region: PRK04147 423368010305 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 423368010306 inhibitor site; inhibition site 423368010307 active site 423368010308 dimer interface [polypeptide binding]; other site 423368010309 catalytic residue [active] 423368010310 transcriptional regulator NanR; Provisional; Region: PRK03837 423368010311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368010312 DNA-binding site [nucleotide binding]; DNA binding site 423368010313 FCD domain; Region: FCD; pfam07729 423368010314 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 423368010315 stringent starvation protein A; Provisional; Region: sspA; PRK09481 423368010316 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 423368010317 C-terminal domain interface [polypeptide binding]; other site 423368010318 putative GSH binding site (G-site) [chemical binding]; other site 423368010319 dimer interface [polypeptide binding]; other site 423368010320 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 423368010321 dimer interface [polypeptide binding]; other site 423368010322 N-terminal domain interface [polypeptide binding]; other site 423368010323 Family of unknown function (DUF695); Region: DUF695; pfam05117 423368010324 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 423368010325 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 423368010326 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 423368010327 23S rRNA interface [nucleotide binding]; other site 423368010328 L3 interface [polypeptide binding]; other site 423368010329 Predicted ATPase [General function prediction only]; Region: COG1485 423368010330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 423368010331 hypothetical protein; Provisional; Region: PRK11677 423368010332 serine endoprotease; Provisional; Region: PRK10139 423368010333 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 423368010334 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 423368010335 protein binding site [polypeptide binding]; other site 423368010336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 423368010337 serine endoprotease; Provisional; Region: PRK10898 423368010338 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 423368010339 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 423368010340 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 423368010341 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 423368010342 oxaloacetate decarboxylase; Provisional; Region: PRK14040 423368010343 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 423368010344 active site 423368010345 catalytic residues [active] 423368010346 metal binding site [ion binding]; metal-binding site 423368010347 homodimer binding site [polypeptide binding]; other site 423368010348 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 423368010349 carboxyltransferase (CT) interaction site; other site 423368010350 biotinylation site [posttranslational modification]; other site 423368010351 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 423368010352 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 423368010353 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 423368010354 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 423368010355 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 423368010356 transmembrane helices; other site 423368010357 Transcriptional regulators [Transcription]; Region: GntR; COG1802 423368010358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368010359 DNA-binding site [nucleotide binding]; DNA binding site 423368010360 FCD domain; Region: FCD; pfam07729 423368010361 Transcriptional regulators [Transcription]; Region: GntR; COG1802 423368010362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368010363 DNA-binding site [nucleotide binding]; DNA binding site 423368010364 malate dehydrogenase; Provisional; Region: PRK05086 423368010365 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 423368010366 NAD binding site [chemical binding]; other site 423368010367 dimerization interface [polypeptide binding]; other site 423368010368 Substrate binding site [chemical binding]; other site 423368010369 arginine repressor; Provisional; Region: PRK05066 423368010370 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 423368010371 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 423368010372 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368010373 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368010374 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 423368010375 RNAase interaction site [polypeptide binding]; other site 423368010376 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 423368010377 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 423368010378 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 423368010379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368010380 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368010381 efflux system membrane protein; Provisional; Region: PRK11594 423368010382 transcriptional regulator; Provisional; Region: PRK10632 423368010383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368010384 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 423368010385 putative effector binding pocket; other site 423368010386 dimerization interface [polypeptide binding]; other site 423368010387 protease TldD; Provisional; Region: tldD; PRK10735 423368010388 hypothetical protein; Provisional; Region: PRK10899 423368010389 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 423368010390 ribonuclease G; Provisional; Region: PRK11712 423368010391 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 423368010392 homodimer interface [polypeptide binding]; other site 423368010393 oligonucleotide binding site [chemical binding]; other site 423368010394 Maf-like protein; Region: Maf; pfam02545 423368010395 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 423368010396 active site 423368010397 dimer interface [polypeptide binding]; other site 423368010398 rod shape-determining protein MreD; Provisional; Region: PRK11060 423368010399 rod shape-determining protein MreC; Region: mreC; TIGR00219 423368010400 rod shape-determining protein MreC; Region: MreC; pfam04085 423368010401 rod shape-determining protein MreB; Provisional; Region: PRK13927 423368010402 MreB and similar proteins; Region: MreB_like; cd10225 423368010403 nucleotide binding site [chemical binding]; other site 423368010404 Mg binding site [ion binding]; other site 423368010405 putative protofilament interaction site [polypeptide binding]; other site 423368010406 RodZ interaction site [polypeptide binding]; other site 423368010407 regulatory protein CsrD; Provisional; Region: PRK11059 423368010408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368010409 metal binding site [ion binding]; metal-binding site 423368010410 active site 423368010411 I-site; other site 423368010412 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368010413 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 423368010414 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 423368010415 NADP binding site [chemical binding]; other site 423368010416 dimer interface [polypeptide binding]; other site 423368010417 TMAO/DMSO reductase; Reviewed; Region: PRK05363 423368010418 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 423368010419 Moco binding site; other site 423368010420 metal coordination site [ion binding]; other site 423368010421 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 423368010422 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 423368010423 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 423368010424 carboxyltransferase (CT) interaction site; other site 423368010425 biotinylation site [posttranslational modification]; other site 423368010426 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 423368010427 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 423368010428 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 423368010429 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 423368010430 hypothetical protein; Provisional; Region: PRK10633 423368010431 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 423368010432 Na binding site [ion binding]; other site 423368010433 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 423368010434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 423368010435 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 423368010436 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 423368010437 FMN binding site [chemical binding]; other site 423368010438 active site 423368010439 catalytic residues [active] 423368010440 substrate binding site [chemical binding]; other site 423368010441 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 423368010442 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 423368010443 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 423368010444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368010445 DNA methylase; Region: N6_N4_Mtase; pfam01555 423368010446 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 423368010447 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 423368010448 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 423368010449 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 423368010450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368010451 metal binding site [ion binding]; metal-binding site 423368010452 active site 423368010453 I-site; other site 423368010454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368010455 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 423368010456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368010457 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 423368010458 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 423368010459 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368010460 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368010461 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 423368010462 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 423368010463 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 423368010464 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 423368010465 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 423368010466 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 423368010467 shikimate binding site; other site 423368010468 NAD(P) binding site [chemical binding]; other site 423368010469 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 423368010470 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368010471 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 423368010472 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368010473 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 423368010474 hypothetical protein; Validated; Region: PRK03430 423368010475 hypothetical protein; Provisional; Region: PRK10736 423368010476 DNA protecting protein DprA; Region: dprA; TIGR00732 423368010477 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 423368010478 active site 423368010479 catalytic residues [active] 423368010480 metal binding site [ion binding]; metal-binding site 423368010481 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 423368010482 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 423368010483 putative active site [active] 423368010484 substrate binding site [chemical binding]; other site 423368010485 putative cosubstrate binding site; other site 423368010486 catalytic site [active] 423368010487 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 423368010488 substrate binding site [chemical binding]; other site 423368010489 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 423368010490 putative RNA binding site [nucleotide binding]; other site 423368010491 16S rRNA methyltransferase B; Provisional; Region: PRK10901 423368010492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368010493 S-adenosylmethionine binding site [chemical binding]; other site 423368010494 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 423368010495 TrkA-N domain; Region: TrkA_N; pfam02254 423368010496 TrkA-C domain; Region: TrkA_C; pfam02080 423368010497 TrkA-N domain; Region: TrkA_N; pfam02254 423368010498 TrkA-C domain; Region: TrkA_C; pfam02080 423368010499 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 423368010500 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 423368010501 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 423368010502 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 423368010503 DNA binding residues [nucleotide binding] 423368010504 dimer interface [polypeptide binding]; other site 423368010505 metal binding site [ion binding]; metal-binding site 423368010506 hypothetical protein; Provisional; Region: PRK10203 423368010507 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 423368010508 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 423368010509 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 423368010510 alphaNTD homodimer interface [polypeptide binding]; other site 423368010511 alphaNTD - beta interaction site [polypeptide binding]; other site 423368010512 alphaNTD - beta' interaction site [polypeptide binding]; other site 423368010513 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 423368010514 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 423368010515 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 423368010516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368010517 RNA binding surface [nucleotide binding]; other site 423368010518 30S ribosomal protein S11; Validated; Region: PRK05309 423368010519 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 423368010520 30S ribosomal protein S13; Region: bact_S13; TIGR03631 423368010521 Alpha operon ribosome binding site 423368010522 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 423368010523 SecY translocase; Region: SecY; pfam00344 423368010524 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 423368010525 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 423368010526 23S rRNA binding site [nucleotide binding]; other site 423368010527 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 423368010528 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 423368010529 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 423368010530 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 423368010531 23S rRNA interface [nucleotide binding]; other site 423368010532 5S rRNA interface [nucleotide binding]; other site 423368010533 L27 interface [polypeptide binding]; other site 423368010534 L5 interface [polypeptide binding]; other site 423368010535 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 423368010536 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 423368010537 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 423368010538 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 423368010539 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 423368010540 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 423368010541 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 423368010542 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 423368010543 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 423368010544 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 423368010545 RNA binding site [nucleotide binding]; other site 423368010546 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 423368010547 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 423368010548 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 423368010549 23S rRNA interface [nucleotide binding]; other site 423368010550 putative translocon interaction site; other site 423368010551 signal recognition particle (SRP54) interaction site; other site 423368010552 L23 interface [polypeptide binding]; other site 423368010553 trigger factor interaction site; other site 423368010554 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 423368010555 23S rRNA interface [nucleotide binding]; other site 423368010556 5S rRNA interface [nucleotide binding]; other site 423368010557 putative antibiotic binding site [chemical binding]; other site 423368010558 L25 interface [polypeptide binding]; other site 423368010559 L27 interface [polypeptide binding]; other site 423368010560 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 423368010561 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 423368010562 G-X-X-G motif; other site 423368010563 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 423368010564 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 423368010565 protein-rRNA interface [nucleotide binding]; other site 423368010566 putative translocon binding site; other site 423368010567 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 423368010568 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 423368010569 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 423368010570 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 423368010571 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 423368010572 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 423368010573 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 423368010574 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 423368010575 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 423368010576 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 423368010577 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 423368010578 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 423368010579 heme binding site [chemical binding]; other site 423368010580 ferroxidase pore; other site 423368010581 ferroxidase diiron center [ion binding]; other site 423368010582 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 423368010583 elongation factor Tu; Reviewed; Region: PRK00049 423368010584 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 423368010585 G1 box; other site 423368010586 GEF interaction site [polypeptide binding]; other site 423368010587 GTP/Mg2+ binding site [chemical binding]; other site 423368010588 Switch I region; other site 423368010589 G2 box; other site 423368010590 G3 box; other site 423368010591 Switch II region; other site 423368010592 G4 box; other site 423368010593 G5 box; other site 423368010594 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 423368010595 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 423368010596 Antibiotic Binding Site [chemical binding]; other site 423368010597 elongation factor G; Reviewed; Region: PRK00007 423368010598 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 423368010599 G1 box; other site 423368010600 putative GEF interaction site [polypeptide binding]; other site 423368010601 GTP/Mg2+ binding site [chemical binding]; other site 423368010602 Switch I region; other site 423368010603 G2 box; other site 423368010604 G3 box; other site 423368010605 Switch II region; other site 423368010606 G4 box; other site 423368010607 G5 box; other site 423368010608 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 423368010609 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 423368010610 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 423368010611 30S ribosomal protein S7; Validated; Region: PRK05302 423368010612 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 423368010613 S17 interaction site [polypeptide binding]; other site 423368010614 S8 interaction site; other site 423368010615 16S rRNA interaction site [nucleotide binding]; other site 423368010616 streptomycin interaction site [chemical binding]; other site 423368010617 23S rRNA interaction site [nucleotide binding]; other site 423368010618 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 423368010619 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 423368010620 sulfur relay protein TusC; Validated; Region: PRK00211 423368010621 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 423368010622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 423368010623 YheO-like PAS domain; Region: PAS_6; pfam08348 423368010624 HTH domain; Region: HTH_22; pfam13309 423368010625 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 423368010626 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 423368010627 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 423368010628 phi X174 lysis protein; Provisional; Region: PRK02793 423368010629 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 423368010630 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 423368010631 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 423368010632 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 423368010633 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 423368010634 TrkA-N domain; Region: TrkA_N; pfam02254 423368010635 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 423368010636 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 423368010637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368010638 Walker A/P-loop; other site 423368010639 ATP binding site [chemical binding]; other site 423368010640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368010641 ABC transporter signature motif; other site 423368010642 Walker B; other site 423368010643 D-loop; other site 423368010644 ABC transporter; Region: ABC_tran_2; pfam12848 423368010645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368010646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368010647 putative monooxygenase; Provisional; Region: PRK11118 423368010648 putative hydrolase; Provisional; Region: PRK10985 423368010649 hypothetical protein; Provisional; Region: PRK04966 423368010650 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 423368010651 active site 423368010652 hypothetical protein; Provisional; Region: PRK10738 423368010653 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 423368010654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 423368010655 ligand binding site [chemical binding]; other site 423368010656 flexible hinge region; other site 423368010657 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 423368010658 putative switch regulator; other site 423368010659 non-specific DNA interactions [nucleotide binding]; other site 423368010660 DNA binding site [nucleotide binding] 423368010661 sequence specific DNA binding site [nucleotide binding]; other site 423368010662 putative cAMP binding site [chemical binding]; other site 423368010663 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 423368010664 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 423368010665 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 423368010666 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 423368010667 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 423368010668 inhibitor-cofactor binding pocket; inhibition site 423368010669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368010670 catalytic residue [active] 423368010671 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 423368010672 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 423368010673 glutamine binding [chemical binding]; other site 423368010674 catalytic triad [active] 423368010675 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 423368010676 cell filamentation protein Fic; Provisional; Region: PRK10347 423368010677 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 423368010678 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 423368010679 substrate binding site [chemical binding]; other site 423368010680 putative transporter; Provisional; Region: PRK03699 423368010681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368010682 putative substrate translocation pore; other site 423368010683 nitrite reductase subunit NirD; Provisional; Region: PRK14989 423368010684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368010685 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 423368010686 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 423368010687 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 423368010688 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 423368010689 nitrite transporter NirC; Provisional; Region: PRK11562 423368010690 siroheme synthase; Provisional; Region: cysG; PRK10637 423368010691 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 423368010692 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 423368010693 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 423368010694 active site 423368010695 SAM binding site [chemical binding]; other site 423368010696 homodimer interface [polypeptide binding]; other site 423368010697 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 423368010698 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 423368010699 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 423368010700 active site 423368010701 HIGH motif; other site 423368010702 dimer interface [polypeptide binding]; other site 423368010703 KMSKS motif; other site 423368010704 phosphoglycolate phosphatase; Provisional; Region: PRK13222 423368010705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368010706 motif II; other site 423368010707 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 423368010708 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 423368010709 substrate binding site [chemical binding]; other site 423368010710 hexamer interface [polypeptide binding]; other site 423368010711 metal binding site [ion binding]; metal-binding site 423368010712 DNA adenine methylase; Provisional; Region: PRK10904 423368010713 cell division protein DamX; Validated; Region: PRK10905 423368010714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 423368010715 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 423368010716 active site 423368010717 dimer interface [polypeptide binding]; other site 423368010718 metal binding site [ion binding]; metal-binding site 423368010719 shikimate kinase; Reviewed; Region: aroK; PRK00131 423368010720 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 423368010721 ADP binding site [chemical binding]; other site 423368010722 magnesium binding site [ion binding]; other site 423368010723 putative shikimate binding site; other site 423368010724 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 423368010725 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 423368010726 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 423368010727 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 423368010728 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 423368010729 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 423368010730 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 423368010731 Transglycosylase; Region: Transgly; pfam00912 423368010732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 423368010733 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 423368010734 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 423368010735 ADP-ribose binding site [chemical binding]; other site 423368010736 dimer interface [polypeptide binding]; other site 423368010737 active site 423368010738 nudix motif; other site 423368010739 metal binding site [ion binding]; metal-binding site 423368010740 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 423368010741 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 423368010742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368010743 motif II; other site 423368010744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368010745 RNA binding surface [nucleotide binding]; other site 423368010746 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 423368010747 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 423368010748 dimerization interface [polypeptide binding]; other site 423368010749 domain crossover interface; other site 423368010750 redox-dependent activation switch; other site 423368010751 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 423368010752 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 423368010753 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 423368010754 active site 423368010755 substrate-binding site [chemical binding]; other site 423368010756 metal-binding site [ion binding] 423368010757 ATP binding site [chemical binding]; other site 423368010758 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 423368010759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368010760 dimerization interface [polypeptide binding]; other site 423368010761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368010762 dimer interface [polypeptide binding]; other site 423368010763 phosphorylation site [posttranslational modification] 423368010764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368010765 ATP binding site [chemical binding]; other site 423368010766 G-X-G motif; other site 423368010767 osmolarity response regulator; Provisional; Region: ompR; PRK09468 423368010768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368010769 active site 423368010770 phosphorylation site [posttranslational modification] 423368010771 intermolecular recognition site; other site 423368010772 dimerization interface [polypeptide binding]; other site 423368010773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368010774 DNA binding site [nucleotide binding] 423368010775 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 423368010776 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 423368010777 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 423368010778 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 423368010779 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 423368010780 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 423368010781 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 423368010782 RNA binding site [nucleotide binding]; other site 423368010783 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 423368010784 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 423368010785 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 423368010786 G1 box; other site 423368010787 GTP/Mg2+ binding site [chemical binding]; other site 423368010788 Switch I region; other site 423368010789 G2 box; other site 423368010790 G3 box; other site 423368010791 Switch II region; other site 423368010792 G4 box; other site 423368010793 G5 box; other site 423368010794 Nucleoside recognition; Region: Gate; pfam07670 423368010795 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 423368010796 Nucleoside recognition; Region: Gate; pfam07670 423368010797 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 423368010798 hypothetical protein; Provisional; Region: PRK09956 423368010799 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 423368010800 carboxylesterase BioH; Provisional; Region: PRK10349 423368010801 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 423368010802 DNA utilization protein GntX; Provisional; Region: PRK11595 423368010803 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368010804 active site 423368010805 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 423368010806 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 423368010807 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 423368010808 high-affinity gluconate transporter; Provisional; Region: PRK14984 423368010809 gluconate transporter; Region: gntP; TIGR00791 423368010810 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 423368010811 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 423368010812 maltodextrin phosphorylase; Provisional; Region: PRK14985 423368010813 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 423368010814 homodimer interface [polypeptide binding]; other site 423368010815 active site pocket [active] 423368010816 transcriptional regulator MalT; Provisional; Region: PRK04841 423368010817 AAA ATPase domain; Region: AAA_16; pfam13191 423368010818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368010819 DNA binding residues [nucleotide binding] 423368010820 dimerization interface [polypeptide binding]; other site 423368010821 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 423368010822 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 423368010823 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368010824 intramembrane serine protease GlpG; Provisional; Region: PRK10907 423368010825 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 423368010826 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 423368010827 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 423368010828 active site residue [active] 423368010829 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 423368010830 hypothetical protein; Provisional; Region: PRK09781 423368010831 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 423368010832 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 423368010833 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 423368010834 dimer interface [polypeptide binding]; other site 423368010835 active site 423368010836 metal binding site [ion binding]; metal-binding site 423368010837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368010838 D-galactonate transporter; Region: 2A0114; TIGR00893 423368010839 putative substrate translocation pore; other site 423368010840 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 423368010841 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 423368010842 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 423368010843 inhibitor site; inhibition site 423368010844 active site 423368010845 dimer interface [polypeptide binding]; other site 423368010846 catalytic residue [active] 423368010847 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 423368010848 Transcriptional regulator [Transcription]; Region: IclR; COG1414 423368010849 Bacterial transcriptional regulator; Region: IclR; pfam01614 423368010850 glycogen phosphorylase; Provisional; Region: PRK14986 423368010851 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 423368010852 homodimer interface [polypeptide binding]; other site 423368010853 active site pocket [active] 423368010854 glycogen synthase; Provisional; Region: glgA; PRK00654 423368010855 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 423368010856 ADP-binding pocket [chemical binding]; other site 423368010857 homodimer interface [polypeptide binding]; other site 423368010858 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 423368010859 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 423368010860 ligand binding site; other site 423368010861 oligomer interface; other site 423368010862 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 423368010863 dimer interface [polypeptide binding]; other site 423368010864 N-terminal domain interface [polypeptide binding]; other site 423368010865 sulfate 1 binding site; other site 423368010866 glycogen debranching enzyme; Provisional; Region: PRK03705 423368010867 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 423368010868 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 423368010869 active site 423368010870 catalytic site [active] 423368010871 glycogen branching enzyme; Provisional; Region: PRK05402 423368010872 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 423368010873 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 423368010874 active site 423368010875 catalytic site [active] 423368010876 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 423368010877 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 423368010878 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 423368010879 low affinity gluconate transporter; Provisional; Region: PRK10472 423368010880 gluconate transporter; Region: gntP; TIGR00791 423368010881 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 423368010882 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 423368010883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368010884 DNA binding site [nucleotide binding] 423368010885 domain linker motif; other site 423368010886 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 423368010887 putative ligand binding site [chemical binding]; other site 423368010888 putative dimerization interface [polypeptide binding]; other site 423368010889 Pirin-related protein [General function prediction only]; Region: COG1741 423368010890 Pirin; Region: Pirin; pfam02678 423368010891 putative oxidoreductase; Provisional; Region: PRK10206 423368010892 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 423368010893 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 423368010894 putative acetyltransferase YhhY; Provisional; Region: PRK10140 423368010895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368010896 Coenzyme A binding pocket [chemical binding]; other site 423368010897 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368010898 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368010899 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368010900 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 423368010901 substrate binding site [chemical binding]; other site 423368010902 dimer interface [polypeptide binding]; other site 423368010903 ATP binding site [chemical binding]; other site 423368010904 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 423368010905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 423368010906 Protein of unknown function, DUF606; Region: DUF606; pfam04657 423368010907 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 423368010908 active site 423368010909 substrate binding pocket [chemical binding]; other site 423368010910 homodimer interaction site [polypeptide binding]; other site 423368010911 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 423368010912 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 423368010913 hypothetical protein; Provisional; Region: PRK10350 423368010914 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 423368010915 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 423368010916 putative active site [active] 423368010917 catalytic site [active] 423368010918 putative metal binding site [ion binding]; other site 423368010919 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 423368010920 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 423368010921 Walker A/P-loop; other site 423368010922 ATP binding site [chemical binding]; other site 423368010923 Q-loop/lid; other site 423368010924 ABC transporter signature motif; other site 423368010925 Walker B; other site 423368010926 D-loop; other site 423368010927 H-loop/switch region; other site 423368010928 TOBE domain; Region: TOBE_2; pfam08402 423368010929 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 423368010930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368010931 dimer interface [polypeptide binding]; other site 423368010932 conserved gate region; other site 423368010933 ABC-ATPase subunit interface; other site 423368010934 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 423368010935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368010936 dimer interface [polypeptide binding]; other site 423368010937 conserved gate region; other site 423368010938 putative PBP binding loops; other site 423368010939 ABC-ATPase subunit interface; other site 423368010940 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 423368010941 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 423368010942 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 423368010943 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 423368010944 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 423368010945 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 423368010946 Walker A/P-loop; other site 423368010947 ATP binding site [chemical binding]; other site 423368010948 Q-loop/lid; other site 423368010949 ABC transporter signature motif; other site 423368010950 Walker B; other site 423368010951 D-loop; other site 423368010952 H-loop/switch region; other site 423368010953 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 423368010954 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 423368010955 Walker A/P-loop; other site 423368010956 ATP binding site [chemical binding]; other site 423368010957 Q-loop/lid; other site 423368010958 ABC transporter signature motif; other site 423368010959 Walker B; other site 423368010960 D-loop; other site 423368010961 H-loop/switch region; other site 423368010962 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 423368010963 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 423368010964 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 423368010965 TM-ABC transporter signature motif; other site 423368010966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 423368010967 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 423368010968 TM-ABC transporter signature motif; other site 423368010969 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 423368010970 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 423368010971 dimerization interface [polypeptide binding]; other site 423368010972 ligand binding site [chemical binding]; other site 423368010973 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 423368010974 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 423368010975 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 423368010976 dimerization interface [polypeptide binding]; other site 423368010977 ligand binding site [chemical binding]; other site 423368010978 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 423368010979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 423368010980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 423368010981 DNA binding residues [nucleotide binding] 423368010982 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 423368010983 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 423368010984 cell division protein FtsE; Provisional; Region: PRK10908 423368010985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368010986 Walker A/P-loop; other site 423368010987 ATP binding site [chemical binding]; other site 423368010988 Q-loop/lid; other site 423368010989 ABC transporter signature motif; other site 423368010990 Walker B; other site 423368010991 D-loop; other site 423368010992 H-loop/switch region; other site 423368010993 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 423368010994 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 423368010995 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 423368010996 P loop; other site 423368010997 GTP binding site [chemical binding]; other site 423368010998 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 423368010999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368011000 S-adenosylmethionine binding site [chemical binding]; other site 423368011001 hypothetical protein; Provisional; Region: PRK10910 423368011002 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 423368011003 Predicted membrane protein [Function unknown]; Region: COG3714 423368011004 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 423368011005 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 423368011006 metal-binding site [ion binding] 423368011007 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 423368011008 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 423368011009 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 423368011010 dimer interface [polypeptide binding]; other site 423368011011 ligand binding site [chemical binding]; other site 423368011012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368011013 dimerization interface [polypeptide binding]; other site 423368011014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368011015 dimer interface [polypeptide binding]; other site 423368011016 putative CheW interface [polypeptide binding]; other site 423368011017 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 423368011018 CPxP motif; other site 423368011019 hypothetical protein; Provisional; Region: PRK11212 423368011020 hypothetical protein; Provisional; Region: PRK11615 423368011021 major facilitator superfamily transporter; Provisional; Region: PRK05122 423368011022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011023 putative substrate translocation pore; other site 423368011024 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 423368011025 Domain of unknown function DUF20; Region: UPF0118; pfam01594 423368011026 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 423368011027 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 423368011028 nickel responsive regulator; Provisional; Region: PRK02967 423368011029 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 423368011030 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 423368011031 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 423368011032 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 423368011033 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 423368011034 Walker A/P-loop; other site 423368011035 ATP binding site [chemical binding]; other site 423368011036 Q-loop/lid; other site 423368011037 ABC transporter signature motif; other site 423368011038 Walker B; other site 423368011039 D-loop; other site 423368011040 H-loop/switch region; other site 423368011041 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 423368011042 Walker A/P-loop; other site 423368011043 ATP binding site [chemical binding]; other site 423368011044 Q-loop/lid; other site 423368011045 ABC transporter signature motif; other site 423368011046 Walker B; other site 423368011047 D-loop; other site 423368011048 H-loop/switch region; other site 423368011049 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 423368011050 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 423368011051 HlyD family secretion protein; Region: HlyD; pfam00529 423368011052 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368011053 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368011054 Predicted flavoproteins [General function prediction only]; Region: COG2081 423368011055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368011056 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 423368011057 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 423368011058 universal stress protein UspB; Provisional; Region: PRK04960 423368011059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 423368011060 Ligand Binding Site [chemical binding]; other site 423368011061 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 423368011062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011063 putative substrate translocation pore; other site 423368011064 POT family; Region: PTR2; pfam00854 423368011065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368011066 S-adenosylmethionine binding site [chemical binding]; other site 423368011067 oligopeptidase A; Provisional; Region: PRK10911 423368011068 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 423368011069 active site 423368011070 Zn binding site [ion binding]; other site 423368011071 hypothetical protein; Provisional; Region: PRK10215 423368011072 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 423368011073 glutathione reductase; Validated; Region: PRK06116 423368011074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 423368011075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368011076 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 423368011077 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 423368011078 active site 423368011079 homodimer interface [polypeptide binding]; other site 423368011080 homotetramer interface [polypeptide binding]; other site 423368011081 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 423368011082 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 423368011083 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 423368011084 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368011085 substrate binding site [chemical binding]; other site 423368011086 ATP binding site [chemical binding]; other site 423368011087 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 423368011088 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 423368011089 putative active site [active] 423368011090 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 423368011091 dimer interface [polypeptide binding]; other site 423368011092 active site 423368011093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 423368011094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368011095 DNA-binding site [nucleotide binding]; DNA binding site 423368011096 UTRA domain; Region: UTRA; pfam07702 423368011097 trehalase; Provisional; Region: treF; PRK13270 423368011098 Trehalase; Region: Trehalase; pfam01204 423368011099 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 423368011100 catalytic residue [active] 423368011101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 423368011102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 423368011103 active site 423368011104 phosphorylation site [posttranslational modification] 423368011105 dimerization interface [polypeptide binding]; other site 423368011106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368011107 DNA binding residues [nucleotide binding] 423368011108 dimerization interface [polypeptide binding]; other site 423368011109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368011110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368011111 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 423368011112 putative effector binding pocket; other site 423368011113 putative dimerization interface [polypeptide binding]; other site 423368011114 inner membrane protein YhjD; Region: TIGR00766 423368011115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011116 metabolite-proton symporter; Region: 2A0106; TIGR00883 423368011117 putative substrate translocation pore; other site 423368011118 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 423368011119 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 423368011120 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368011121 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368011122 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 423368011123 substrate binding site [chemical binding]; other site 423368011124 ATP binding site [chemical binding]; other site 423368011125 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 423368011126 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 423368011127 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 423368011128 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 423368011129 putative diguanylate cyclase; Provisional; Region: PRK13561 423368011130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368011131 metal binding site [ion binding]; metal-binding site 423368011132 active site 423368011133 I-site; other site 423368011134 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368011135 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 423368011136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 423368011137 TPR motif; other site 423368011138 binding surface 423368011139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 423368011140 TPR motif; other site 423368011141 binding surface 423368011142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 423368011143 binding surface 423368011144 TPR motif; other site 423368011145 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 423368011146 endo-1,4-D-glucanase; Provisional; Region: PRK11097 423368011147 cellulose synthase regulator protein; Provisional; Region: PRK11114 423368011148 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 423368011149 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 423368011150 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 423368011151 DXD motif; other site 423368011152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 423368011153 PilZ domain; Region: PilZ; pfam07238 423368011154 cell division protein; Provisional; Region: PRK10037 423368011155 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 423368011156 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 423368011157 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 423368011158 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 423368011159 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 423368011160 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 423368011161 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 423368011162 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 423368011163 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368011164 Walker A/P-loop; other site 423368011165 ATP binding site [chemical binding]; other site 423368011166 Q-loop/lid; other site 423368011167 ABC transporter signature motif; other site 423368011168 Walker B; other site 423368011169 D-loop; other site 423368011170 H-loop/switch region; other site 423368011171 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 423368011172 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 423368011173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 423368011174 Walker A/P-loop; other site 423368011175 ATP binding site [chemical binding]; other site 423368011176 Q-loop/lid; other site 423368011177 ABC transporter signature motif; other site 423368011178 Walker B; other site 423368011179 D-loop; other site 423368011180 H-loop/switch region; other site 423368011181 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 423368011182 dipeptide transporter; Provisional; Region: PRK10913 423368011183 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 423368011184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368011185 dimer interface [polypeptide binding]; other site 423368011186 conserved gate region; other site 423368011187 putative PBP binding loops; other site 423368011188 ABC-ATPase subunit interface; other site 423368011189 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 423368011190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368011191 dimer interface [polypeptide binding]; other site 423368011192 conserved gate region; other site 423368011193 putative PBP binding loops; other site 423368011194 ABC-ATPase subunit interface; other site 423368011195 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 423368011196 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 423368011197 peptide binding site [polypeptide binding]; other site 423368011198 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 423368011199 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 423368011200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 423368011201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368011202 DNA binding site [nucleotide binding] 423368011203 domain linker motif; other site 423368011204 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 423368011205 putative dimerization interface [polypeptide binding]; other site 423368011206 putative ligand binding site [chemical binding]; other site 423368011207 phosphoethanolamine transferase; Provisional; Region: PRK11560 423368011208 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 423368011209 Sulfatase; Region: Sulfatase; pfam00884 423368011210 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 423368011211 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 423368011212 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 423368011213 PapC N-terminal domain; Region: PapC_N; pfam13954 423368011214 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368011215 PapC C-terminal domain; Region: PapC_C; pfam13953 423368011216 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 423368011217 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368011218 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368011219 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 423368011220 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 423368011221 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 423368011222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 423368011223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368011224 Coenzyme A binding pocket [chemical binding]; other site 423368011225 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 423368011226 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 423368011227 molybdopterin cofactor binding site [chemical binding]; other site 423368011228 substrate binding site [chemical binding]; other site 423368011229 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 423368011230 molybdopterin cofactor binding site; other site 423368011231 putative outer membrane lipoprotein; Provisional; Region: PRK10510 423368011232 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 423368011233 ligand binding site [chemical binding]; other site 423368011234 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 423368011235 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 423368011236 dimerization interface [polypeptide binding]; other site 423368011237 ligand binding site [chemical binding]; other site 423368011238 NADP binding site [chemical binding]; other site 423368011239 catalytic site [active] 423368011240 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 423368011241 Predicted transcriptional regulator [Transcription]; Region: COG2944 423368011242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368011243 salt bridge; other site 423368011244 non-specific DNA binding site [nucleotide binding]; other site 423368011245 sequence-specific DNA binding site [nucleotide binding]; other site 423368011246 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 423368011247 DNA-binding site [nucleotide binding]; DNA binding site 423368011248 RNA-binding motif; other site 423368011249 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 423368011250 DALR anticodon binding domain; Region: DALR_1; pfam05746 423368011251 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 423368011252 dimer interface [polypeptide binding]; other site 423368011253 motif 1; other site 423368011254 active site 423368011255 motif 2; other site 423368011256 motif 3; other site 423368011257 YsaB-like lipoprotein; Region: YsaB; pfam13983 423368011258 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 423368011259 Acyltransferase family; Region: Acyl_transf_3; pfam01757 423368011260 Predicted membrane protein [Function unknown]; Region: COG4682 423368011261 yiaA/B two helix domain; Region: YiaAB; cl01759 423368011262 yiaA/B two helix domain; Region: YiaAB; cl01759 423368011263 xylulokinase; Provisional; Region: PRK15027 423368011264 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 423368011265 N- and C-terminal domain interface [polypeptide binding]; other site 423368011266 active site 423368011267 MgATP binding site [chemical binding]; other site 423368011268 catalytic site [active] 423368011269 metal binding site [ion binding]; metal-binding site 423368011270 xylulose binding site [chemical binding]; other site 423368011271 homodimer interface [polypeptide binding]; other site 423368011272 xylose isomerase; Provisional; Region: PRK05474 423368011273 xylose isomerase; Region: xylose_isom_A; TIGR02630 423368011274 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 423368011275 putative dimerization interface [polypeptide binding]; other site 423368011276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 423368011277 putative ligand binding site [chemical binding]; other site 423368011278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368011279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368011280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368011281 hypothetical protein; Provisional; Region: PRK10356 423368011282 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 423368011283 alpha-amylase; Reviewed; Region: malS; PRK09505 423368011284 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 423368011285 active site 423368011286 catalytic site [active] 423368011287 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 423368011288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368011289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368011290 homodimer interface [polypeptide binding]; other site 423368011291 catalytic residue [active] 423368011292 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 423368011293 Transcriptional regulator [Transcription]; Region: IclR; COG1414 423368011294 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 423368011295 Bacterial transcriptional regulator; Region: IclR; pfam01614 423368011296 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 423368011297 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 423368011298 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 423368011299 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 423368011300 DctM-like transporters; Region: DctM; pfam06808 423368011301 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 423368011302 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 423368011303 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 423368011304 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 423368011305 putative N- and C-terminal domain interface [polypeptide binding]; other site 423368011306 putative active site [active] 423368011307 MgATP binding site [chemical binding]; other site 423368011308 catalytic site [active] 423368011309 metal binding site [ion binding]; metal-binding site 423368011310 putative xylulose binding site [chemical binding]; other site 423368011311 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 423368011312 active site 423368011313 dimer interface [polypeptide binding]; other site 423368011314 magnesium binding site [ion binding]; other site 423368011315 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 423368011316 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 423368011317 AP (apurinic/apyrimidinic) site pocket; other site 423368011318 DNA interaction; other site 423368011319 Metal-binding active site; metal-binding site 423368011320 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 423368011321 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 423368011322 intersubunit interface [polypeptide binding]; other site 423368011323 active site 423368011324 Zn2+ binding site [ion binding]; other site 423368011325 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 423368011326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 423368011327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368011328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 423368011329 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 423368011330 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 423368011331 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 423368011332 NAD(P) binding site [chemical binding]; other site 423368011333 catalytic residues [active] 423368011334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 423368011335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 423368011336 nucleotide binding site [chemical binding]; other site 423368011337 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 423368011338 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 423368011339 G1 box; other site 423368011340 putative GEF interaction site [polypeptide binding]; other site 423368011341 GTP/Mg2+ binding site [chemical binding]; other site 423368011342 Switch I region; other site 423368011343 G2 box; other site 423368011344 G3 box; other site 423368011345 Switch II region; other site 423368011346 G4 box; other site 423368011347 G5 box; other site 423368011348 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 423368011349 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 423368011350 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 423368011351 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 423368011352 selenocysteine synthase; Provisional; Region: PRK04311 423368011353 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 423368011354 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 423368011355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368011356 catalytic residue [active] 423368011357 putative glutathione S-transferase; Provisional; Region: PRK10357 423368011358 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 423368011359 putative C-terminal domain interface [polypeptide binding]; other site 423368011360 putative GSH binding site (G-site) [chemical binding]; other site 423368011361 putative dimer interface [polypeptide binding]; other site 423368011362 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 423368011363 dimer interface [polypeptide binding]; other site 423368011364 N-terminal domain interface [polypeptide binding]; other site 423368011365 putative substrate binding pocket (H-site) [chemical binding]; other site 423368011366 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 423368011367 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 423368011368 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 423368011369 active site 423368011370 P-loop; other site 423368011371 phosphorylation site [posttranslational modification] 423368011372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368011373 active site 423368011374 phosphorylation site [posttranslational modification] 423368011375 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 423368011376 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 423368011377 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 423368011378 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 423368011379 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 423368011380 hypothetical protein; Provisional; Region: PRK11020 423368011381 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 423368011382 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 423368011383 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 423368011384 trimer interface [polypeptide binding]; other site 423368011385 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 423368011386 Haemagglutinin; Region: HIM; pfam05662 423368011387 Haemagglutinin; Region: HIM; pfam05662 423368011388 YadA-like C-terminal region; Region: YadA; pfam03895 423368011389 L-lactate permease; Provisional; Region: PRK10420 423368011390 glycolate transporter; Provisional; Region: PRK09695 423368011391 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 423368011392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368011393 DNA-binding site [nucleotide binding]; DNA binding site 423368011394 FCD domain; Region: FCD; pfam07729 423368011395 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 423368011396 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 423368011397 active site 423368011398 substrate binding site [chemical binding]; other site 423368011399 FMN binding site [chemical binding]; other site 423368011400 putative catalytic residues [active] 423368011401 putative rRNA methylase; Provisional; Region: PRK10358 423368011402 Transcriptional regulators [Transcription]; Region: PurR; COG1609 423368011403 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368011404 DNA binding site [nucleotide binding] 423368011405 domain linker motif; other site 423368011406 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 423368011407 putative dimerization interface [polypeptide binding]; other site 423368011408 putative ligand binding site [chemical binding]; other site 423368011409 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 423368011410 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 423368011411 active site pocket [active] 423368011412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011413 D-galactonate transporter; Region: 2A0114; TIGR00893 423368011414 putative substrate translocation pore; other site 423368011415 serine acetyltransferase; Provisional; Region: cysE; PRK11132 423368011416 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 423368011417 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 423368011418 trimer interface [polypeptide binding]; other site 423368011419 active site 423368011420 substrate binding site [chemical binding]; other site 423368011421 CoA binding site [chemical binding]; other site 423368011422 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 423368011423 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 423368011424 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 423368011425 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 423368011426 SecA binding site; other site 423368011427 Preprotein binding site; other site 423368011428 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 423368011429 GSH binding site [chemical binding]; other site 423368011430 catalytic residues [active] 423368011431 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 423368011432 active site residue [active] 423368011433 phosphoglyceromutase; Provisional; Region: PRK05434 423368011434 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 423368011435 AmiB activator; Provisional; Region: PRK11637 423368011436 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 423368011437 Peptidase family M23; Region: Peptidase_M23; pfam01551 423368011438 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 423368011439 NodB motif; other site 423368011440 putative active site [active] 423368011441 putative catalytic site [active] 423368011442 Zn binding site [ion binding]; other site 423368011443 putative glycosyl transferase; Provisional; Region: PRK10073 423368011444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 423368011445 active site 423368011446 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 423368011447 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 423368011448 NAD(P) binding site [chemical binding]; other site 423368011449 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 423368011450 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 423368011451 substrate-cofactor binding pocket; other site 423368011452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368011453 catalytic residue [active] 423368011454 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 423368011455 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 423368011456 NADP binding site [chemical binding]; other site 423368011457 homopentamer interface [polypeptide binding]; other site 423368011458 substrate binding site [chemical binding]; other site 423368011459 active site 423368011460 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 423368011461 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 423368011462 putative active site [active] 423368011463 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 423368011464 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 423368011465 putative active site [active] 423368011466 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 423368011467 O-antigen ligase RfaL; Provisional; Region: PRK15487 423368011468 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 423368011469 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 423368011470 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 423368011471 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 423368011472 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 423368011473 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 423368011474 Ligand binding site; other site 423368011475 metal-binding site 423368011476 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 423368011477 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 423368011478 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 423368011479 Ligand binding site; other site 423368011480 metal-binding site 423368011481 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 423368011482 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 423368011483 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 423368011484 putative ADP-binding pocket [chemical binding]; other site 423368011485 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 423368011486 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 423368011487 Ligand binding site; other site 423368011488 metal-binding site 423368011489 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 423368011490 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 423368011491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 423368011492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 423368011493 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 423368011494 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 423368011495 putative active site [active] 423368011496 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 423368011497 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 423368011498 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 423368011499 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 423368011500 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 423368011501 active site 423368011502 (T/H)XGH motif; other site 423368011503 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 423368011504 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 423368011505 DNA binding site [nucleotide binding] 423368011506 catalytic residue [active] 423368011507 H2TH interface [polypeptide binding]; other site 423368011508 putative catalytic residues [active] 423368011509 turnover-facilitating residue; other site 423368011510 intercalation triad [nucleotide binding]; other site 423368011511 8OG recognition residue [nucleotide binding]; other site 423368011512 putative reading head residues; other site 423368011513 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 423368011514 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 423368011515 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 423368011516 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 423368011517 hypothetical protein; Reviewed; Region: PRK00024 423368011518 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 423368011519 MPN+ (JAMM) motif; other site 423368011520 Zinc-binding site [ion binding]; other site 423368011521 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 423368011522 Flavoprotein; Region: Flavoprotein; pfam02441 423368011523 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 423368011524 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 423368011525 trimer interface [polypeptide binding]; other site 423368011526 active site 423368011527 division inhibitor protein; Provisional; Region: slmA; PRK09480 423368011528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368011529 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 423368011530 active site 423368011531 ribonuclease PH; Reviewed; Region: rph; PRK00173 423368011532 Ribonuclease PH; Region: RNase_PH_bact; cd11362 423368011533 hexamer interface [polypeptide binding]; other site 423368011534 active site 423368011535 hypothetical protein; Provisional; Region: PRK11820 423368011536 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 423368011537 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 423368011538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368011539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368011540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 423368011541 dimerization interface [polypeptide binding]; other site 423368011542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 423368011543 Predicted membrane protein [Function unknown]; Region: COG2860 423368011544 UPF0126 domain; Region: UPF0126; pfam03458 423368011545 UPF0126 domain; Region: UPF0126; pfam03458 423368011546 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 423368011547 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 423368011548 nucleotide binding pocket [chemical binding]; other site 423368011549 K-X-D-G motif; other site 423368011550 catalytic site [active] 423368011551 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 423368011552 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 423368011553 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 423368011554 catalytic site [active] 423368011555 G-X2-G-X-G-K; other site 423368011556 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 423368011557 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 423368011558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 423368011559 Zn2+ binding site [ion binding]; other site 423368011560 Mg2+ binding site [ion binding]; other site 423368011561 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 423368011562 synthetase active site [active] 423368011563 NTP binding site [chemical binding]; other site 423368011564 metal binding site [ion binding]; metal-binding site 423368011565 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 423368011566 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 423368011567 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 423368011568 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 423368011569 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 423368011570 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 423368011571 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 423368011572 generic binding surface II; other site 423368011573 ssDNA binding site; other site 423368011574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368011575 ATP binding site [chemical binding]; other site 423368011576 putative Mg++ binding site [ion binding]; other site 423368011577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368011578 nucleotide binding region [chemical binding]; other site 423368011579 ATP-binding site [chemical binding]; other site 423368011580 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 423368011581 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 423368011582 AsmA family; Region: AsmA; pfam05170 423368011583 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 423368011584 putative alpha-glucosidase; Provisional; Region: PRK10658 423368011585 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 423368011586 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 423368011587 active site 423368011588 homotrimer interface [polypeptide binding]; other site 423368011589 catalytic site [active] 423368011590 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 423368011591 putative transporter; Provisional; Region: PRK11462 423368011592 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 423368011593 Transposase; Region: HTH_Tnp_1; cl17663 423368011594 autotransport protein MisL; Provisional; Region: PRK15313 423368011595 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 423368011596 Autotransporter beta-domain; Region: Autotransporter; pfam03797 423368011597 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 423368011598 DNA binding site [nucleotide binding] 423368011599 Isochorismatase family; Region: Isochorismatase; pfam00857 423368011600 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 423368011601 catalytic triad [active] 423368011602 dimer interface [polypeptide binding]; other site 423368011603 conserved cis-peptide bond; other site 423368011604 magnesium-transporting ATPase; Provisional; Region: PRK15122 423368011605 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 423368011606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 423368011607 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 423368011608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368011609 motif II; other site 423368011610 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 423368011611 magnesium transport protein MgtC; Provisional; Region: PRK15385 423368011612 MgtC family; Region: MgtC; pfam02308 423368011613 EamA-like transporter family; Region: EamA; pfam00892 423368011614 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 423368011615 EamA-like transporter family; Region: EamA; pfam00892 423368011616 hypothetical protein; Provisional; Region: PRK09956 423368011617 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 423368011618 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 423368011619 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 423368011620 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 423368011621 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 423368011622 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 423368011623 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 423368011624 active site 423368011625 phosphorylation site [posttranslational modification] 423368011626 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368011627 active pocket/dimerization site; other site 423368011628 active site 423368011629 phosphorylation site [posttranslational modification] 423368011630 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 423368011631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368011632 Walker A motif; other site 423368011633 ATP binding site [chemical binding]; other site 423368011634 Walker B motif; other site 423368011635 arginine finger; other site 423368011636 Transcriptional antiterminator [Transcription]; Region: COG3933 423368011637 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 423368011638 active site 423368011639 active pocket/dimerization site; other site 423368011640 phosphorylation site [posttranslational modification] 423368011641 PRD domain; Region: PRD; pfam00874 423368011642 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 423368011643 beta-galactosidase; Region: BGL; TIGR03356 423368011644 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 423368011645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011646 putative substrate translocation pore; other site 423368011647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 423368011648 Predicted transcriptional regulator [Transcription]; Region: COG2944 423368011649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368011650 non-specific DNA binding site [nucleotide binding]; other site 423368011651 salt bridge; other site 423368011652 sequence-specific DNA binding site [nucleotide binding]; other site 423368011653 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 423368011654 dimerization domain swap beta strand [polypeptide binding]; other site 423368011655 regulatory protein interface [polypeptide binding]; other site 423368011656 active site 423368011657 regulatory phosphorylation site [posttranslational modification]; other site 423368011658 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 423368011659 intersubunit interface [polypeptide binding]; other site 423368011660 active site 423368011661 zinc binding site [ion binding]; other site 423368011662 Na+ binding site [ion binding]; other site 423368011663 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 423368011664 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 423368011665 putative N- and C-terminal domain interface [polypeptide binding]; other site 423368011666 putative active site [active] 423368011667 putative MgATP binding site [chemical binding]; other site 423368011668 catalytic site [active] 423368011669 metal binding site [ion binding]; metal-binding site 423368011670 putative carbohydrate binding site [chemical binding]; other site 423368011671 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 423368011672 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 423368011673 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 423368011674 active site 423368011675 P-loop; other site 423368011676 phosphorylation site [posttranslational modification] 423368011677 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368011678 active site 423368011679 phosphorylation site [posttranslational modification] 423368011680 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 423368011681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368011682 DNA-binding site [nucleotide binding]; DNA binding site 423368011683 UTRA domain; Region: UTRA; pfam07702 423368011684 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 423368011685 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 423368011686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011687 putative substrate translocation pore; other site 423368011688 regulatory protein UhpC; Provisional; Region: PRK11663 423368011689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011690 putative substrate translocation pore; other site 423368011691 sensory histidine kinase UhpB; Provisional; Region: PRK11644 423368011692 MASE1; Region: MASE1; pfam05231 423368011693 Histidine kinase; Region: HisKA_3; pfam07730 423368011694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368011695 ATP binding site [chemical binding]; other site 423368011696 Mg2+ binding site [ion binding]; other site 423368011697 G-X-G motif; other site 423368011698 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 423368011699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368011700 active site 423368011701 phosphorylation site [posttranslational modification] 423368011702 intermolecular recognition site; other site 423368011703 dimerization interface [polypeptide binding]; other site 423368011704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368011705 DNA binding residues [nucleotide binding] 423368011706 dimerization interface [polypeptide binding]; other site 423368011707 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 423368011708 active site 423368011709 catalytic residues [active] 423368011710 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 423368011711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011712 putative substrate translocation pore; other site 423368011713 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368011714 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 423368011715 substrate binding site [chemical binding]; other site 423368011716 dimer interface [polypeptide binding]; other site 423368011717 ATP binding site [chemical binding]; other site 423368011718 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 423368011719 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 423368011720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368011721 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 423368011722 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 423368011723 putative valine binding site [chemical binding]; other site 423368011724 dimer interface [polypeptide binding]; other site 423368011725 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 423368011726 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 423368011727 PYR/PP interface [polypeptide binding]; other site 423368011728 dimer interface [polypeptide binding]; other site 423368011729 TPP binding site [chemical binding]; other site 423368011730 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 423368011731 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 423368011732 TPP-binding site [chemical binding]; other site 423368011733 dimer interface [polypeptide binding]; other site 423368011734 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 423368011735 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 423368011736 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 423368011737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011738 putative substrate translocation pore; other site 423368011739 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 423368011740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368011741 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 423368011742 dimerization interface [polypeptide binding]; other site 423368011743 substrate binding pocket [chemical binding]; other site 423368011744 permease DsdX; Provisional; Region: PRK09921 423368011745 gluconate transporter; Region: gntP; TIGR00791 423368011746 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 423368011747 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 423368011748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 423368011749 catalytic residue [active] 423368011750 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 423368011751 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 423368011752 Domain of unknown function (DUF202); Region: DUF202; pfam02656 423368011753 Predicted membrane protein [Function unknown]; Region: COG2149 423368011754 putative transporter; Validated; Region: PRK03818 423368011755 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 423368011756 TrkA-C domain; Region: TrkA_C; pfam02080 423368011757 TrkA-C domain; Region: TrkA_C; pfam02080 423368011758 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 423368011759 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 423368011760 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 423368011761 putative dimer interface [polypeptide binding]; other site 423368011762 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 423368011763 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 423368011764 putative dimer interface [polypeptide binding]; other site 423368011765 hypothetical protein; Provisional; Region: PRK11616 423368011766 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 423368011767 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 423368011768 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 423368011769 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 423368011770 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 423368011771 catalytic residues [active] 423368011772 central insert; other site 423368011773 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 423368011774 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 423368011775 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 423368011776 heme exporter protein CcmC; Region: ccmC; TIGR01191 423368011777 heme exporter protein CcmB; Region: ccmB; TIGR01190 423368011778 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 423368011779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368011780 Walker A/P-loop; other site 423368011781 ATP binding site [chemical binding]; other site 423368011782 Q-loop/lid; other site 423368011783 ABC transporter signature motif; other site 423368011784 Walker B; other site 423368011785 D-loop; other site 423368011786 H-loop/switch region; other site 423368011787 Haem-binding domain; Region: Haem_bd; pfam14376 423368011788 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 423368011789 chaperone protein TorD; Validated; Region: torD; PRK04976 423368011790 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 423368011791 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 423368011792 molybdopterin cofactor binding site [chemical binding]; other site 423368011793 substrate binding site [chemical binding]; other site 423368011794 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 423368011795 molybdopterin cofactor binding site; other site 423368011796 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 423368011797 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 423368011798 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 423368011799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368011800 active site 423368011801 phosphorylation site [posttranslational modification] 423368011802 intermolecular recognition site; other site 423368011803 dimerization interface [polypeptide binding]; other site 423368011804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368011805 DNA binding site [nucleotide binding] 423368011806 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 423368011807 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 423368011808 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 423368011809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368011810 dimer interface [polypeptide binding]; other site 423368011811 phosphorylation site [posttranslational modification] 423368011812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368011813 ATP binding site [chemical binding]; other site 423368011814 Mg2+ binding site [ion binding]; other site 423368011815 G-X-G motif; other site 423368011816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368011817 active site 423368011818 phosphorylation site [posttranslational modification] 423368011819 intermolecular recognition site; other site 423368011820 dimerization interface [polypeptide binding]; other site 423368011821 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 423368011822 putative binding surface; other site 423368011823 active site 423368011824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011825 D-galactonate transporter; Region: 2A0114; TIGR00893 423368011826 putative substrate translocation pore; other site 423368011827 galactonate dehydratase; Provisional; Region: PRK14017 423368011828 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 423368011829 putative active site pocket [active] 423368011830 putative metal binding site [ion binding]; other site 423368011831 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 423368011832 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 423368011833 active site 423368011834 intersubunit interface [polypeptide binding]; other site 423368011835 catalytic residue [active] 423368011836 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 423368011837 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 423368011838 Transcriptional regulators [Transcription]; Region: FadR; COG2186 423368011839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368011840 DNA-binding site [nucleotide binding]; DNA binding site 423368011841 FCD domain; Region: FCD; pfam07729 423368011842 sugar phosphate phosphatase; Provisional; Region: PRK10513 423368011843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368011844 active site 423368011845 motif I; other site 423368011846 motif II; other site 423368011847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368011848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011849 D-galactonate transporter; Region: 2A0114; TIGR00893 423368011850 putative substrate translocation pore; other site 423368011851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011852 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 423368011853 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 423368011854 active site pocket [active] 423368011855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368011856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368011857 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 423368011858 putative dimerization interface [polypeptide binding]; other site 423368011859 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 423368011860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368011861 Mg2+ binding site [ion binding]; other site 423368011862 G-X-G motif; other site 423368011863 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 423368011864 anchoring element; other site 423368011865 dimer interface [polypeptide binding]; other site 423368011866 ATP binding site [chemical binding]; other site 423368011867 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 423368011868 active site 423368011869 putative metal-binding site [ion binding]; other site 423368011870 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 423368011871 recF protein; Region: recf; TIGR00611 423368011872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368011873 Walker A/P-loop; other site 423368011874 ATP binding site [chemical binding]; other site 423368011875 Q-loop/lid; other site 423368011876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368011877 ABC transporter signature motif; other site 423368011878 Walker B; other site 423368011879 D-loop; other site 423368011880 H-loop/switch region; other site 423368011881 DNA polymerase III subunit beta; Validated; Region: PRK05643 423368011882 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 423368011883 putative DNA binding surface [nucleotide binding]; other site 423368011884 dimer interface [polypeptide binding]; other site 423368011885 beta-clamp/clamp loader binding surface; other site 423368011886 beta-clamp/translesion DNA polymerase binding surface; other site 423368011887 DnaA N-terminal domain; Region: DnaA_N; pfam11638 423368011888 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 423368011889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368011890 Walker A motif; other site 423368011891 ATP binding site [chemical binding]; other site 423368011892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 423368011893 Walker B motif; other site 423368011894 arginine finger; other site 423368011895 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 423368011896 DnaA box-binding interface [nucleotide binding]; other site 423368011897 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 423368011898 ribonuclease P; Reviewed; Region: rnpA; PRK01732 423368011899 membrane protein insertase; Provisional; Region: PRK01318 423368011900 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 423368011901 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 423368011902 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 423368011903 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 423368011904 trmE is a tRNA modification GTPase; Region: trmE; cd04164 423368011905 G1 box; other site 423368011906 GTP/Mg2+ binding site [chemical binding]; other site 423368011907 Switch I region; other site 423368011908 G2 box; other site 423368011909 Switch II region; other site 423368011910 G3 box; other site 423368011911 G4 box; other site 423368011912 G5 box; other site 423368011913 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 423368011914 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 423368011915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368011916 putative substrate translocation pore; other site 423368011917 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 423368011918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368011919 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 423368011920 substrate binding pocket [chemical binding]; other site 423368011921 dimerization interface [polypeptide binding]; other site 423368011922 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 423368011923 Predicted flavoprotein [General function prediction only]; Region: COG0431 423368011924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 423368011925 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 423368011926 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 423368011927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368011928 active site 423368011929 motif I; other site 423368011930 motif II; other site 423368011931 transcriptional regulator PhoU; Provisional; Region: PRK11115 423368011932 PhoU domain; Region: PhoU; pfam01895 423368011933 PhoU domain; Region: PhoU; pfam01895 423368011934 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 423368011935 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 423368011936 Walker A/P-loop; other site 423368011937 ATP binding site [chemical binding]; other site 423368011938 Q-loop/lid; other site 423368011939 ABC transporter signature motif; other site 423368011940 Walker B; other site 423368011941 D-loop; other site 423368011942 H-loop/switch region; other site 423368011943 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 423368011944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368011945 dimer interface [polypeptide binding]; other site 423368011946 conserved gate region; other site 423368011947 putative PBP binding loops; other site 423368011948 ABC-ATPase subunit interface; other site 423368011949 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 423368011950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368011951 dimer interface [polypeptide binding]; other site 423368011952 conserved gate region; other site 423368011953 putative PBP binding loops; other site 423368011954 ABC-ATPase subunit interface; other site 423368011955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368011956 substrate binding pocket [chemical binding]; other site 423368011957 membrane-bound complex binding site; other site 423368011958 hinge residues; other site 423368011959 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 423368011960 active site 423368011961 P-loop; other site 423368011962 phosphorylation site [posttranslational modification] 423368011963 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 423368011964 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 423368011965 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 423368011966 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 423368011967 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 423368011968 shikimate binding site; other site 423368011969 NAD(P) binding site [chemical binding]; other site 423368011970 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 423368011971 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 423368011972 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 423368011973 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 423368011974 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 423368011975 glutaminase active site [active] 423368011976 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 423368011977 dimer interface [polypeptide binding]; other site 423368011978 active site 423368011979 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 423368011980 dimer interface [polypeptide binding]; other site 423368011981 active site 423368011982 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 423368011983 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 423368011984 Substrate binding site; other site 423368011985 Mg++ binding site; other site 423368011986 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 423368011987 active site 423368011988 substrate binding site [chemical binding]; other site 423368011989 CoA binding site [chemical binding]; other site 423368011990 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 423368011991 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 423368011992 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 423368011993 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 423368011994 gamma subunit interface [polypeptide binding]; other site 423368011995 epsilon subunit interface [polypeptide binding]; other site 423368011996 LBP interface [polypeptide binding]; other site 423368011997 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 423368011998 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 423368011999 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 423368012000 alpha subunit interaction interface [polypeptide binding]; other site 423368012001 Walker A motif; other site 423368012002 ATP binding site [chemical binding]; other site 423368012003 Walker B motif; other site 423368012004 inhibitor binding site; inhibition site 423368012005 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 423368012006 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 423368012007 core domain interface [polypeptide binding]; other site 423368012008 delta subunit interface [polypeptide binding]; other site 423368012009 epsilon subunit interface [polypeptide binding]; other site 423368012010 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 423368012011 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 423368012012 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 423368012013 beta subunit interaction interface [polypeptide binding]; other site 423368012014 Walker A motif; other site 423368012015 ATP binding site [chemical binding]; other site 423368012016 Walker B motif; other site 423368012017 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 423368012018 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 423368012019 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 423368012020 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 423368012021 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 423368012022 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 423368012023 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 423368012024 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 423368012025 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 423368012026 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 423368012027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368012028 S-adenosylmethionine binding site [chemical binding]; other site 423368012029 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 423368012030 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 423368012031 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 423368012032 FMN-binding protein MioC; Provisional; Region: PRK09004 423368012033 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 423368012034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368012035 putative DNA binding site [nucleotide binding]; other site 423368012036 putative Zn2+ binding site [ion binding]; other site 423368012037 AsnC family; Region: AsnC_trans_reg; pfam01037 423368012038 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 423368012039 dimer interface [polypeptide binding]; other site 423368012040 active site 423368012041 hypothetical protein; Provisional; Region: yieM; PRK10997 423368012042 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 423368012043 metal ion-dependent adhesion site (MIDAS); other site 423368012044 regulatory ATPase RavA; Provisional; Region: PRK13531 423368012045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368012046 Walker A motif; other site 423368012047 ATP binding site [chemical binding]; other site 423368012048 Walker B motif; other site 423368012049 arginine finger; other site 423368012050 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 423368012051 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 423368012052 potassium uptake protein; Region: kup; TIGR00794 423368012053 D-ribose pyranase; Provisional; Region: PRK11797 423368012054 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 423368012055 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 423368012056 Walker A/P-loop; other site 423368012057 ATP binding site [chemical binding]; other site 423368012058 Q-loop/lid; other site 423368012059 ABC transporter signature motif; other site 423368012060 Walker B; other site 423368012061 D-loop; other site 423368012062 H-loop/switch region; other site 423368012063 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 423368012064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 423368012065 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 423368012066 TM-ABC transporter signature motif; other site 423368012067 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 423368012068 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 423368012069 ligand binding site [chemical binding]; other site 423368012070 dimerization interface [polypeptide binding]; other site 423368012071 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368012072 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 423368012073 substrate binding site [chemical binding]; other site 423368012074 dimer interface [polypeptide binding]; other site 423368012075 ATP binding site [chemical binding]; other site 423368012076 transcriptional repressor RbsR; Provisional; Region: PRK10423 423368012077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368012078 DNA binding site [nucleotide binding] 423368012079 domain linker motif; other site 423368012080 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 423368012081 dimerization interface [polypeptide binding]; other site 423368012082 ligand binding site [chemical binding]; other site 423368012083 putative transporter; Provisional; Region: PRK10504 423368012084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368012085 putative substrate translocation pore; other site 423368012086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368012087 Transcriptional regulators [Transcription]; Region: FadR; COG2186 423368012088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368012089 DNA-binding site [nucleotide binding]; DNA binding site 423368012090 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 423368012091 transcriptional regulator HdfR; Provisional; Region: PRK03601 423368012092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368012093 LysR substrate binding domain; Region: LysR_substrate; pfam03466 423368012094 dimerization interface [polypeptide binding]; other site 423368012095 hypothetical protein; Provisional; Region: PRK11027 423368012096 putative ATP-dependent protease; Provisional; Region: PRK09862 423368012097 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 423368012098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368012099 Walker A motif; other site 423368012100 ATP binding site [chemical binding]; other site 423368012101 Walker B motif; other site 423368012102 arginine finger; other site 423368012103 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 423368012104 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 423368012105 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 423368012106 PYR/PP interface [polypeptide binding]; other site 423368012107 dimer interface [polypeptide binding]; other site 423368012108 TPP binding site [chemical binding]; other site 423368012109 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 423368012110 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 423368012111 TPP-binding site [chemical binding]; other site 423368012112 dimer interface [polypeptide binding]; other site 423368012113 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 423368012114 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 423368012115 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 423368012116 homodimer interface [polypeptide binding]; other site 423368012117 substrate-cofactor binding pocket; other site 423368012118 catalytic residue [active] 423368012119 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 423368012120 threonine dehydratase; Reviewed; Region: PRK09224 423368012121 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 423368012122 tetramer interface [polypeptide binding]; other site 423368012123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368012124 catalytic residue [active] 423368012125 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 423368012126 putative Ile/Val binding site [chemical binding]; other site 423368012127 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 423368012128 putative Ile/Val binding site [chemical binding]; other site 423368012129 Phage-related protein [Function unknown]; Region: COG4679 423368012130 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 423368012131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368012132 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 423368012133 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 423368012134 putative dimerization interface [polypeptide binding]; other site 423368012135 ketol-acid reductoisomerase; Validated; Region: PRK05225 423368012136 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 423368012137 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 423368012138 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 423368012139 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 423368012140 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 423368012141 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 423368012142 Part of AAA domain; Region: AAA_19; pfam13245 423368012143 Family description; Region: UvrD_C_2; pfam13538 423368012144 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 423368012145 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 423368012146 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 423368012147 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 423368012148 ATP binding site [chemical binding]; other site 423368012149 Mg++ binding site [ion binding]; other site 423368012150 motif III; other site 423368012151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368012152 nucleotide binding region [chemical binding]; other site 423368012153 ATP-binding site [chemical binding]; other site 423368012154 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 423368012155 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 423368012156 catalytic residues [active] 423368012157 transcription termination factor Rho; Provisional; Region: rho; PRK09376 423368012158 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 423368012159 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 423368012160 RNA binding site [nucleotide binding]; other site 423368012161 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 423368012162 multimer interface [polypeptide binding]; other site 423368012163 Walker A motif; other site 423368012164 ATP binding site [chemical binding]; other site 423368012165 Walker B motif; other site 423368012166 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 423368012167 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 423368012168 Mg++ binding site [ion binding]; other site 423368012169 putative catalytic motif [active] 423368012170 substrate binding site [chemical binding]; other site 423368012171 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 423368012172 Chain length determinant protein; Region: Wzz; pfam02706 423368012173 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 423368012174 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 423368012175 active site 423368012176 homodimer interface [polypeptide binding]; other site 423368012177 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 423368012178 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 423368012179 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 423368012180 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 423368012181 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 423368012182 NAD binding site [chemical binding]; other site 423368012183 substrate binding site [chemical binding]; other site 423368012184 homodimer interface [polypeptide binding]; other site 423368012185 active site 423368012186 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 423368012187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 423368012188 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 423368012189 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 423368012190 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 423368012191 inhibitor-cofactor binding pocket; inhibition site 423368012192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368012193 catalytic residue [active] 423368012194 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 423368012195 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 423368012196 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 423368012197 putative common antigen polymerase; Provisional; Region: PRK02975 423368012198 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 423368012199 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 423368012200 putative transport protein YifK; Provisional; Region: PRK10746 423368012201 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 423368012202 HemY protein N-terminus; Region: HemY_N; pfam07219 423368012203 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 423368012204 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 423368012205 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 423368012206 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 423368012207 active site 423368012208 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 423368012209 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 423368012210 domain interfaces; other site 423368012211 active site 423368012212 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 423368012213 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 423368012214 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 423368012215 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 423368012216 putative iron binding site [ion binding]; other site 423368012217 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 423368012218 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 423368012219 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 423368012220 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 423368012221 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 423368012222 hypothetical protein; Provisional; Region: PRK10963 423368012223 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 423368012224 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 423368012225 active site 423368012226 Int/Topo IB signature motif; other site 423368012227 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 423368012228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368012229 motif II; other site 423368012230 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 423368012231 Part of AAA domain; Region: AAA_19; pfam13245 423368012232 Family description; Region: UvrD_C_2; pfam13538 423368012233 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 423368012234 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 423368012235 Cl binding site [ion binding]; other site 423368012236 oligomer interface [polypeptide binding]; other site 423368012237 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 423368012238 EamA-like transporter family; Region: EamA; cl17759 423368012239 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 423368012240 CoenzymeA binding site [chemical binding]; other site 423368012241 subunit interaction site [polypeptide binding]; other site 423368012242 PHB binding site; other site 423368012243 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 423368012244 dimerization interface [polypeptide binding]; other site 423368012245 substrate binding site [chemical binding]; other site 423368012246 active site 423368012247 calcium binding site [ion binding]; other site 423368012248 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 423368012249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368012250 ATP binding site [chemical binding]; other site 423368012251 putative Mg++ binding site [ion binding]; other site 423368012252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368012253 nucleotide binding region [chemical binding]; other site 423368012254 ATP-binding site [chemical binding]; other site 423368012255 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 423368012256 Helicase and RNase D C-terminal; Region: HRDC; smart00341 423368012257 threonine efflux system; Provisional; Region: PRK10229 423368012258 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 423368012259 lysophospholipase L2; Provisional; Region: PRK10749 423368012260 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 423368012261 putative hydrolase; Provisional; Region: PRK10976 423368012262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368012263 active site 423368012264 motif I; other site 423368012265 motif II; other site 423368012266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368012267 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 423368012268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368012269 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 423368012270 putative dimerization interface [polypeptide binding]; other site 423368012271 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 423368012272 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 423368012273 THF binding site; other site 423368012274 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 423368012275 substrate binding site [chemical binding]; other site 423368012276 THF binding site; other site 423368012277 zinc-binding site [ion binding]; other site 423368012278 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 423368012279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368012280 FeS/SAM binding site; other site 423368012281 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 423368012282 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 423368012283 uridine phosphorylase; Provisional; Region: PRK11178 423368012284 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 423368012285 DNA recombination protein RmuC; Provisional; Region: PRK10361 423368012286 RmuC family; Region: RmuC; pfam02646 423368012287 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 423368012288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368012289 S-adenosylmethionine binding site [chemical binding]; other site 423368012290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 423368012291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 423368012292 SCP-2 sterol transfer family; Region: SCP2; pfam02036 423368012293 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 423368012294 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 423368012295 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 423368012296 sec-independent translocase; Provisional; Region: PRK01770 423368012297 sec-independent translocase; Provisional; Region: tatB; PRK00404 423368012298 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 423368012299 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 423368012300 active site 423368012301 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 423368012302 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 423368012303 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 423368012304 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 423368012305 FMN reductase; Validated; Region: fre; PRK08051 423368012306 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 423368012307 FAD binding pocket [chemical binding]; other site 423368012308 FAD binding motif [chemical binding]; other site 423368012309 phosphate binding motif [ion binding]; other site 423368012310 beta-alpha-beta structure motif; other site 423368012311 NAD binding pocket [chemical binding]; other site 423368012312 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 423368012313 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 423368012314 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 423368012315 dimer interface [polypeptide binding]; other site 423368012316 active site 423368012317 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 423368012318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 423368012319 substrate binding site [chemical binding]; other site 423368012320 oxyanion hole (OAH) forming residues; other site 423368012321 trimer interface [polypeptide binding]; other site 423368012322 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 423368012323 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 423368012324 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 423368012325 proline dipeptidase; Provisional; Region: PRK13607 423368012326 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 423368012327 active site 423368012328 hypothetical protein; Provisional; Region: PRK11568 423368012329 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 423368012330 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 423368012331 potassium transporter; Provisional; Region: PRK10750 423368012332 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 423368012333 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 423368012334 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 423368012335 Walker A motif; other site 423368012336 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 423368012337 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 423368012338 GTP binding site; other site 423368012339 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 423368012340 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 423368012341 serine/threonine protein kinase; Provisional; Region: PRK11768 423368012342 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 423368012343 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 423368012344 catalytic residues [active] 423368012345 hinge region; other site 423368012346 alpha helical domain; other site 423368012347 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 423368012348 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 423368012349 putative acyl-acceptor binding pocket; other site 423368012350 DNA polymerase I; Provisional; Region: PRK05755 423368012351 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 423368012352 active site 423368012353 metal binding site 1 [ion binding]; metal-binding site 423368012354 putative 5' ssDNA interaction site; other site 423368012355 metal binding site 3; metal-binding site 423368012356 metal binding site 2 [ion binding]; metal-binding site 423368012357 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 423368012358 putative DNA binding site [nucleotide binding]; other site 423368012359 putative metal binding site [ion binding]; other site 423368012360 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 423368012361 active site 423368012362 catalytic site [active] 423368012363 substrate binding site [chemical binding]; other site 423368012364 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 423368012365 active site 423368012366 DNA binding site [nucleotide binding] 423368012367 catalytic site [active] 423368012368 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 423368012369 G1 box; other site 423368012370 GTP/Mg2+ binding site [chemical binding]; other site 423368012371 Switch I region; other site 423368012372 G2 box; other site 423368012373 G3 box; other site 423368012374 Switch II region; other site 423368012375 G4 box; other site 423368012376 G5 box; other site 423368012377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 423368012378 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 423368012379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368012380 FeS/SAM binding site; other site 423368012381 HemN C-terminal domain; Region: HemN_C; pfam06969 423368012382 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 423368012383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368012384 active site 423368012385 phosphorylation site [posttranslational modification] 423368012386 intermolecular recognition site; other site 423368012387 dimerization interface [polypeptide binding]; other site 423368012388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368012389 Walker A motif; other site 423368012390 ATP binding site [chemical binding]; other site 423368012391 Walker B motif; other site 423368012392 arginine finger; other site 423368012393 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 423368012394 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 423368012395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 423368012396 putative active site [active] 423368012397 heme pocket [chemical binding]; other site 423368012398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368012399 dimer interface [polypeptide binding]; other site 423368012400 phosphorylation site [posttranslational modification] 423368012401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368012402 ATP binding site [chemical binding]; other site 423368012403 Mg2+ binding site [ion binding]; other site 423368012404 G-X-G motif; other site 423368012405 glutamine synthetase; Provisional; Region: glnA; PRK09469 423368012406 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 423368012407 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 423368012408 GTP-binding protein; Provisional; Region: PRK10218 423368012409 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 423368012410 G1 box; other site 423368012411 putative GEF interaction site [polypeptide binding]; other site 423368012412 GTP/Mg2+ binding site [chemical binding]; other site 423368012413 Switch I region; other site 423368012414 G2 box; other site 423368012415 G3 box; other site 423368012416 Switch II region; other site 423368012417 G4 box; other site 423368012418 G5 box; other site 423368012419 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 423368012420 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 423368012421 outer membrane porin L; Provisional; Region: ompL; PRK09980 423368012422 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 423368012423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368012424 putative substrate translocation pore; other site 423368012425 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 423368012426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368012427 putative substrate translocation pore; other site 423368012428 alpha-glucosidase; Provisional; Region: PRK10426 423368012429 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 423368012430 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 423368012431 putative active site [active] 423368012432 putative catalytic site [active] 423368012433 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 423368012434 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 423368012435 active site 423368012436 catalytic residues [active] 423368012437 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 423368012438 dimerization interface [polypeptide binding]; other site 423368012439 putative active cleft [active] 423368012440 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 423368012441 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 423368012442 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 423368012443 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368012444 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 423368012445 substrate binding site [chemical binding]; other site 423368012446 ATP binding site [chemical binding]; other site 423368012447 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368012448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 423368012449 putative DNA binding site [nucleotide binding]; other site 423368012450 putative Zn2+ binding site [ion binding]; other site 423368012451 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368012452 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 423368012453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368012454 motif II; other site 423368012455 hypothetical protein; Reviewed; Region: PRK01637 423368012456 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 423368012457 putative active site [active] 423368012458 dimerization interface [polypeptide binding]; other site 423368012459 putative tRNAtyr binding site [nucleotide binding]; other site 423368012460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368012461 Coenzyme A binding pocket [chemical binding]; other site 423368012462 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 423368012463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368012464 non-specific DNA binding site [nucleotide binding]; other site 423368012465 salt bridge; other site 423368012466 sequence-specific DNA binding site [nucleotide binding]; other site 423368012467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 423368012468 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 423368012469 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 423368012470 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 423368012471 Predicted transcriptional regulator [Transcription]; Region: COG2944 423368012472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368012473 non-specific DNA binding site [nucleotide binding]; other site 423368012474 salt bridge; other site 423368012475 sequence-specific DNA binding site [nucleotide binding]; other site 423368012476 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 423368012477 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 423368012478 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 423368012479 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 423368012480 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 423368012481 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 423368012482 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 423368012483 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 423368012484 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 423368012485 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 423368012486 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 423368012487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368012488 non-specific DNA binding site [nucleotide binding]; other site 423368012489 salt bridge; other site 423368012490 sequence-specific DNA binding site [nucleotide binding]; other site 423368012491 Cupin domain; Region: Cupin_2; cl17218 423368012492 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 423368012493 lactaldehyde reductase; Region: lactal_redase; TIGR02638 423368012494 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 423368012495 dimer interface [polypeptide binding]; other site 423368012496 active site 423368012497 metal binding site [ion binding]; metal-binding site 423368012498 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 423368012499 intersubunit interface [polypeptide binding]; other site 423368012500 active site 423368012501 Zn2+ binding site [ion binding]; other site 423368012502 L-rhamnose isomerase; Provisional; Region: PRK01076 423368012503 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 423368012504 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 423368012505 N- and C-terminal domain interface [polypeptide binding]; other site 423368012506 active site 423368012507 putative catalytic site [active] 423368012508 metal binding site [ion binding]; metal-binding site 423368012509 ATP binding site [chemical binding]; other site 423368012510 rhamnulokinase; Provisional; Region: rhaB; PRK10640 423368012511 carbohydrate binding site [chemical binding]; other site 423368012512 transcriptional activator RhaS; Provisional; Region: PRK13503 423368012513 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 423368012514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368012515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368012516 transcriptional activator RhaR; Provisional; Region: PRK13502 423368012517 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 423368012518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368012519 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 423368012520 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 423368012521 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 423368012522 DctM-like transporters; Region: DctM; pfam06808 423368012523 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 423368012524 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 423368012525 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 423368012526 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 423368012527 superoxide dismutase; Provisional; Region: PRK10925 423368012528 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 423368012529 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 423368012530 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 423368012531 MOSC domain; Region: MOSC; pfam03473 423368012532 3-alpha domain; Region: 3-alpha; pfam03475 423368012533 SnoaL-like domain; Region: SnoaL_2; pfam12680 423368012534 two-component sensor protein; Provisional; Region: cpxA; PRK09470 423368012535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368012536 dimerization interface [polypeptide binding]; other site 423368012537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368012538 dimer interface [polypeptide binding]; other site 423368012539 phosphorylation site [posttranslational modification] 423368012540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368012541 ATP binding site [chemical binding]; other site 423368012542 Mg2+ binding site [ion binding]; other site 423368012543 G-X-G motif; other site 423368012544 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 423368012545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368012546 active site 423368012547 intermolecular recognition site; other site 423368012548 dimerization interface [polypeptide binding]; other site 423368012549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368012550 DNA binding site [nucleotide binding] 423368012551 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 423368012552 dimer interface [polypeptide binding]; other site 423368012553 integrase; Provisional; Region: int; PHA02601 423368012554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 423368012555 active site 423368012556 DNA binding site [nucleotide binding] 423368012557 Int/Topo IB signature motif; other site 423368012558 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 423368012559 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 423368012560 Fic/DOC family; Region: Fic; pfam02661 423368012561 portal vertex protein; Provisional; Region: Q; PHA02536 423368012562 Phage portal protein; Region: Phage_portal; pfam04860 423368012563 terminase ATPase subunit; Provisional; Region: P; PHA02535 423368012564 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 423368012565 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 423368012566 capsid protein; Provisional; Region: N; PHA02538 423368012567 terminase endonuclease subunit; Provisional; Region: M; PHA02537 423368012568 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 423368012569 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 423368012570 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 423368012571 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 423368012572 catalytic residues [active] 423368012573 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 423368012574 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 423368012575 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 423368012576 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 423368012577 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 423368012578 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 423368012579 baseplate wedge subunit; Provisional; Region: W; PHA02516 423368012580 baseplate assembly protein; Provisional; Region: J; PHA02568 423368012581 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 423368012582 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 423368012583 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368012584 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368012585 Phage Tail Collar Domain; Region: Collar; pfam07484 423368012586 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368012587 major tail sheath protein; Provisional; Region: FI; PHA02560 423368012588 major tail tube protein; Provisional; Region: FII; PHA02600 423368012589 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 423368012590 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 423368012591 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 423368012592 tail protein; Provisional; Region: D; PHA02561 423368012593 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 423368012594 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 423368012595 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 423368012596 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 423368012597 active site 423368012598 ADP/pyrophosphate binding site [chemical binding]; other site 423368012599 dimerization interface [polypeptide binding]; other site 423368012600 allosteric effector site; other site 423368012601 fructose-1,6-bisphosphate binding site; other site 423368012602 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 423368012603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368012604 substrate binding pocket [chemical binding]; other site 423368012605 membrane-bound complex binding site; other site 423368012606 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 423368012607 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 423368012608 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 423368012609 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 423368012610 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 423368012611 putative substrate binding site [chemical binding]; other site 423368012612 putative ATP binding site [chemical binding]; other site 423368012613 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 423368012614 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 423368012615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368012616 DNA-binding site [nucleotide binding]; DNA binding site 423368012617 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 423368012618 UTRA domain; Region: UTRA; pfam07702 423368012619 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 423368012620 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 423368012621 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 423368012622 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 423368012623 putative N- and C-terminal domain interface [polypeptide binding]; other site 423368012624 putative active site [active] 423368012625 putative MgATP binding site [chemical binding]; other site 423368012626 catalytic site [active] 423368012627 metal binding site [ion binding]; metal-binding site 423368012628 putative carbohydrate binding site [chemical binding]; other site 423368012629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 423368012630 transcriptional regulator LsrR; Provisional; Region: PRK15418 423368012631 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 423368012632 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 423368012633 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 423368012634 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 423368012635 Walker A/P-loop; other site 423368012636 ATP binding site [chemical binding]; other site 423368012637 Q-loop/lid; other site 423368012638 ABC transporter signature motif; other site 423368012639 Walker B; other site 423368012640 D-loop; other site 423368012641 H-loop/switch region; other site 423368012642 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 423368012643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 423368012644 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 423368012645 TM-ABC transporter signature motif; other site 423368012646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 423368012647 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 423368012648 TM-ABC transporter signature motif; other site 423368012649 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 423368012650 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 423368012651 ligand binding site [chemical binding]; other site 423368012652 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 423368012653 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 423368012654 putative active site; other site 423368012655 catalytic residue [active] 423368012656 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 423368012657 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 423368012658 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 423368012659 substrate binding site [chemical binding]; other site 423368012660 hexamer interface [polypeptide binding]; other site 423368012661 metal binding site [ion binding]; metal-binding site 423368012662 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 423368012663 triosephosphate isomerase; Provisional; Region: PRK14567 423368012664 substrate binding site [chemical binding]; other site 423368012665 dimer interface [polypeptide binding]; other site 423368012666 catalytic triad [active] 423368012667 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 423368012668 Predicted membrane protein [Function unknown]; Region: COG3152 423368012669 ferredoxin-NADP reductase; Provisional; Region: PRK10926 423368012670 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 423368012671 FAD binding pocket [chemical binding]; other site 423368012672 FAD binding motif [chemical binding]; other site 423368012673 phosphate binding motif [ion binding]; other site 423368012674 beta-alpha-beta structure motif; other site 423368012675 NAD binding pocket [chemical binding]; other site 423368012676 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 423368012677 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 423368012678 putative active site [active] 423368012679 glycerol kinase; Provisional; Region: glpK; PRK00047 423368012680 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 423368012681 N- and C-terminal domain interface [polypeptide binding]; other site 423368012682 active site 423368012683 MgATP binding site [chemical binding]; other site 423368012684 catalytic site [active] 423368012685 metal binding site [ion binding]; metal-binding site 423368012686 glycerol binding site [chemical binding]; other site 423368012687 homotetramer interface [polypeptide binding]; other site 423368012688 homodimer interface [polypeptide binding]; other site 423368012689 FBP binding site [chemical binding]; other site 423368012690 protein IIAGlc interface [polypeptide binding]; other site 423368012691 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 423368012692 amphipathic channel; other site 423368012693 Asn-Pro-Ala signature motifs; other site 423368012694 septal ring assembly protein ZapB; Provisional; Region: PRK15422 423368012695 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 423368012696 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 423368012697 UbiA prenyltransferase family; Region: UbiA; pfam01040 423368012698 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 423368012699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368012700 Walker A motif; other site 423368012701 ATP binding site [chemical binding]; other site 423368012702 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 423368012703 Walker B motif; other site 423368012704 arginine finger; other site 423368012705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 423368012706 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 423368012707 active site 423368012708 HslU subunit interaction site [polypeptide binding]; other site 423368012709 essential cell division protein FtsN; Provisional; Region: PRK10927 423368012710 cell division protein FtsN; Provisional; Region: PRK12757 423368012711 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368012712 DNA binding site [nucleotide binding] 423368012713 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 423368012714 domain linker motif; other site 423368012715 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 423368012716 dimerization interface [polypeptide binding]; other site 423368012717 ligand binding site [chemical binding]; other site 423368012718 primosome assembly protein PriA; Validated; Region: PRK05580 423368012719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368012720 ATP binding site [chemical binding]; other site 423368012721 putative Mg++ binding site [ion binding]; other site 423368012722 helicase superfamily c-terminal domain; Region: HELICc; smart00490 423368012723 ATP-binding site [chemical binding]; other site 423368012724 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 423368012725 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 423368012726 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 423368012727 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 423368012728 dimerization interface [polypeptide binding]; other site 423368012729 DNA binding site [nucleotide binding] 423368012730 corepressor binding sites; other site 423368012731 cystathionine gamma-synthase; Provisional; Region: PRK08045 423368012732 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 423368012733 homodimer interface [polypeptide binding]; other site 423368012734 substrate-cofactor binding pocket; other site 423368012735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368012736 catalytic residue [active] 423368012737 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 423368012738 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 423368012739 putative catalytic residues [active] 423368012740 putative nucleotide binding site [chemical binding]; other site 423368012741 putative aspartate binding site [chemical binding]; other site 423368012742 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 423368012743 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 423368012744 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 423368012745 mechanosensitive channel MscS; Provisional; Region: PRK10334 423368012746 Conserved TM helix; Region: TM_helix; pfam05552 423368012747 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368012748 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 423368012749 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 423368012750 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 423368012751 active site 423368012752 metal binding site [ion binding]; metal-binding site 423368012753 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 423368012754 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 423368012755 FAD binding site [chemical binding]; other site 423368012756 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 423368012757 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 423368012758 heme binding site [chemical binding]; other site 423368012759 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 423368012760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 423368012761 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 423368012762 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 423368012763 dimer interface [polypeptide binding]; other site 423368012764 active site 423368012765 metal binding site [ion binding]; metal-binding site 423368012766 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 423368012767 active site 423368012768 intersubunit interactions; other site 423368012769 catalytic residue [active] 423368012770 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 423368012771 dimerization domain swap beta strand [polypeptide binding]; other site 423368012772 regulatory protein interface [polypeptide binding]; other site 423368012773 active site 423368012774 regulatory phosphorylation site [posttranslational modification]; other site 423368012775 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 423368012776 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 423368012777 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 423368012778 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 423368012779 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368012780 active site 423368012781 phosphorylation site [posttranslational modification] 423368012782 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 423368012783 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 423368012784 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 423368012785 active site 423368012786 P-loop; other site 423368012787 phosphorylation site [posttranslational modification] 423368012788 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 423368012789 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 423368012790 dimer interface [polypeptide binding]; other site 423368012791 active site 423368012792 glycine loop; other site 423368012793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368012794 FeS/SAM binding site; other site 423368012795 pyruvate formate lyase II activase; Provisional; Region: PRK10076 423368012796 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 423368012797 active site 423368012798 P-loop; other site 423368012799 phosphorylation site [posttranslational modification] 423368012800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 423368012801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368012802 hypothetical protein; Provisional; Region: PRK10649 423368012803 Sulfatase; Region: Sulfatase; pfam00884 423368012804 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 423368012805 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 423368012806 acetylornithine deacetylase; Provisional; Region: PRK05111 423368012807 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 423368012808 metal binding site [ion binding]; metal-binding site 423368012809 putative dimer interface [polypeptide binding]; other site 423368012810 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 423368012811 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 423368012812 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 423368012813 nucleotide binding site [chemical binding]; other site 423368012814 N-acetyl-L-glutamate binding site [chemical binding]; other site 423368012815 argininosuccinate lyase; Provisional; Region: PRK04833 423368012816 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 423368012817 active sites [active] 423368012818 tetramer interface [polypeptide binding]; other site 423368012819 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 423368012820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368012821 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 423368012822 dimerization interface [polypeptide binding]; other site 423368012823 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 423368012824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 423368012825 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 423368012826 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 423368012827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368012828 hypothetical protein; Provisional; Region: PRK11056 423368012829 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 423368012830 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 423368012831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368012832 S-adenosylmethionine binding site [chemical binding]; other site 423368012833 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 423368012834 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 423368012835 N-terminal plug; other site 423368012836 ligand-binding site [chemical binding]; other site 423368012837 glutamate racemase; Provisional; Region: PRK00865 423368012838 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 423368012839 FAD binding domain; Region: FAD_binding_4; pfam01565 423368012840 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 423368012841 Biotin operon repressor [Transcription]; Region: BirA; COG1654 423368012842 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 423368012843 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 423368012844 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 423368012845 pantothenate kinase; Provisional; Region: PRK05439 423368012846 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 423368012847 ATP-binding site [chemical binding]; other site 423368012848 CoA-binding site [chemical binding]; other site 423368012849 Mg2+-binding site [ion binding]; other site 423368012850 elongation factor Tu; Reviewed; Region: PRK00049 423368012851 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 423368012852 G1 box; other site 423368012853 GEF interaction site [polypeptide binding]; other site 423368012854 GTP/Mg2+ binding site [chemical binding]; other site 423368012855 Switch I region; other site 423368012856 G2 box; other site 423368012857 G3 box; other site 423368012858 Switch II region; other site 423368012859 G4 box; other site 423368012860 G5 box; other site 423368012861 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 423368012862 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 423368012863 Antibiotic Binding Site [chemical binding]; other site 423368012864 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 423368012865 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 423368012866 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 423368012867 putative homodimer interface [polypeptide binding]; other site 423368012868 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 423368012869 heterodimer interface [polypeptide binding]; other site 423368012870 homodimer interface [polypeptide binding]; other site 423368012871 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 423368012872 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 423368012873 23S rRNA interface [nucleotide binding]; other site 423368012874 L7/L12 interface [polypeptide binding]; other site 423368012875 putative thiostrepton binding site; other site 423368012876 L25 interface [polypeptide binding]; other site 423368012877 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 423368012878 mRNA/rRNA interface [nucleotide binding]; other site 423368012879 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 423368012880 23S rRNA interface [nucleotide binding]; other site 423368012881 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 423368012882 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 423368012883 core dimer interface [polypeptide binding]; other site 423368012884 peripheral dimer interface [polypeptide binding]; other site 423368012885 L10 interface [polypeptide binding]; other site 423368012886 L11 interface [polypeptide binding]; other site 423368012887 putative EF-Tu interaction site [polypeptide binding]; other site 423368012888 putative EF-G interaction site [polypeptide binding]; other site 423368012889 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 423368012890 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 423368012891 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 423368012892 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 423368012893 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 423368012894 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 423368012895 RPB3 interaction site [polypeptide binding]; other site 423368012896 RPB1 interaction site [polypeptide binding]; other site 423368012897 RPB11 interaction site [polypeptide binding]; other site 423368012898 RPB10 interaction site [polypeptide binding]; other site 423368012899 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 423368012900 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 423368012901 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 423368012902 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 423368012903 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 423368012904 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 423368012905 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 423368012906 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 423368012907 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 423368012908 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 423368012909 DNA binding site [nucleotide binding] 423368012910 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 423368012911 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 423368012912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368012913 FeS/SAM binding site; other site 423368012914 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 423368012915 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 423368012916 ThiS interaction site; other site 423368012917 putative active site [active] 423368012918 tetramer interface [polypeptide binding]; other site 423368012919 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 423368012920 thiS-thiF/thiG interaction site; other site 423368012921 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 423368012922 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 423368012923 ATP binding site [chemical binding]; other site 423368012924 substrate interface [chemical binding]; other site 423368012925 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 423368012926 thiamine phosphate binding site [chemical binding]; other site 423368012927 active site 423368012928 pyrophosphate binding site [ion binding]; other site 423368012929 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 423368012930 ThiC-associated domain; Region: ThiC-associated; pfam13667 423368012931 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 423368012932 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 423368012933 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 423368012934 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 423368012935 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 423368012936 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 423368012937 putative NADH binding site [chemical binding]; other site 423368012938 putative active site [active] 423368012939 nudix motif; other site 423368012940 putative metal binding site [ion binding]; other site 423368012941 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 423368012942 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 423368012943 substrate binding site [chemical binding]; other site 423368012944 active site 423368012945 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 423368012946 Active_site [active] 423368012947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 423368012948 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 423368012949 IHF dimer interface [polypeptide binding]; other site 423368012950 IHF - DNA interface [nucleotide binding]; other site 423368012951 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 423368012952 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 423368012953 dimer interface [polypeptide binding]; other site 423368012954 sensor protein ZraS; Provisional; Region: PRK10364 423368012955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368012956 dimer interface [polypeptide binding]; other site 423368012957 phosphorylation site [posttranslational modification] 423368012958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368012959 ATP binding site [chemical binding]; other site 423368012960 Mg2+ binding site [ion binding]; other site 423368012961 G-X-G motif; other site 423368012962 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 423368012963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368012964 active site 423368012965 phosphorylation site [posttranslational modification] 423368012966 intermolecular recognition site; other site 423368012967 dimerization interface [polypeptide binding]; other site 423368012968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368012969 Walker A motif; other site 423368012970 ATP binding site [chemical binding]; other site 423368012971 Walker B motif; other site 423368012972 arginine finger; other site 423368012973 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 423368012974 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 423368012975 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 423368012976 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 423368012977 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 423368012978 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 423368012979 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 423368012980 purine monophosphate binding site [chemical binding]; other site 423368012981 dimer interface [polypeptide binding]; other site 423368012982 putative catalytic residues [active] 423368012983 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 423368012984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 423368012985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368012986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 423368012987 Coenzyme A binding pocket [chemical binding]; other site 423368012988 homoserine O-succinyltransferase; Provisional; Region: PRK05368 423368012989 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 423368012990 proposed active site lysine [active] 423368012991 conserved cys residue [active] 423368012992 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 423368012993 malate synthase A; Region: malate_syn_A; TIGR01344 423368012994 active site 423368012995 isocitrate lyase; Provisional; Region: PRK15063 423368012996 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 423368012997 tetramer interface [polypeptide binding]; other site 423368012998 active site 423368012999 Mg2+/Mn2+ binding site [ion binding]; other site 423368013000 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 423368013001 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 423368013002 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 423368013003 transcriptional repressor IclR; Provisional; Region: PRK11569 423368013004 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 423368013005 Bacterial transcriptional regulator; Region: IclR; pfam01614 423368013006 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 423368013007 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 423368013008 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 423368013009 substrate binding pocket [chemical binding]; other site 423368013010 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 423368013011 B12 binding site [chemical binding]; other site 423368013012 cobalt ligand [ion binding]; other site 423368013013 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 423368013014 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 423368013015 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 423368013016 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 423368013017 active site pocket [active] 423368013018 oxyanion hole [active] 423368013019 catalytic triad [active] 423368013020 active site nucleophile [active] 423368013021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 423368013022 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 423368013023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 423368013024 RNA binding surface [nucleotide binding]; other site 423368013025 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 423368013026 probable active site [active] 423368013027 hypothetical protein; Provisional; Region: PRK10515 423368013028 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 423368013029 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 423368013030 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368013031 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 423368013032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368013033 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 423368013034 active site 423368013035 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 423368013036 phosphate binding site [ion binding]; other site 423368013037 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 423368013038 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 423368013039 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 423368013040 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368013041 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 423368013042 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 423368013043 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 423368013044 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 423368013045 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 423368013046 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 423368013047 Ligand binding site; other site 423368013048 Putative Catalytic site; other site 423368013049 DXD motif; other site 423368013050 Predicted membrane protein [Function unknown]; Region: COG2246 423368013051 GtrA-like protein; Region: GtrA; pfam04138 423368013052 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 423368013053 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 423368013054 Phage protein D [General function prediction only]; Region: COG3500 423368013055 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 423368013056 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 423368013057 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 423368013058 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 423368013059 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 423368013060 Phage tail tube protein FII [General function prediction only]; Region: COG3498 423368013061 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 423368013062 Gp37 protein; Region: Gp37; pfam09646 423368013063 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 423368013064 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368013065 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368013066 catalytic residue [active] 423368013067 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 423368013068 Mor transcription activator family; Region: Mor; pfam08765 423368013069 aspartate kinase III; Validated; Region: PRK09084 423368013070 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 423368013071 nucleotide binding site [chemical binding]; other site 423368013072 substrate binding site [chemical binding]; other site 423368013073 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 423368013074 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 423368013075 dimer interface [polypeptide binding]; other site 423368013076 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 423368013077 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 423368013078 active site 423368013079 dimer interface [polypeptide binding]; other site 423368013080 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 423368013081 dimer interface [polypeptide binding]; other site 423368013082 active site 423368013083 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 423368013084 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 423368013085 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 423368013086 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 423368013087 Predicted membrane protein [Function unknown]; Region: COG3223 423368013088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 423368013089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368013090 dimer interface [polypeptide binding]; other site 423368013091 conserved gate region; other site 423368013092 putative PBP binding loops; other site 423368013093 ABC-ATPase subunit interface; other site 423368013094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 423368013095 dimer interface [polypeptide binding]; other site 423368013096 conserved gate region; other site 423368013097 putative PBP binding loops; other site 423368013098 ABC-ATPase subunit interface; other site 423368013099 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 423368013100 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 423368013101 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 423368013102 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 423368013103 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 423368013104 Walker A/P-loop; other site 423368013105 ATP binding site [chemical binding]; other site 423368013106 Q-loop/lid; other site 423368013107 ABC transporter signature motif; other site 423368013108 Walker B; other site 423368013109 D-loop; other site 423368013110 H-loop/switch region; other site 423368013111 TOBE domain; Region: TOBE_2; pfam08402 423368013112 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 423368013113 trimer interface; other site 423368013114 sugar binding site [chemical binding]; other site 423368013115 maltose regulon periplasmic protein; Provisional; Region: PRK10564 423368013116 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 423368013117 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 423368013118 UbiA prenyltransferase family; Region: UbiA; pfam01040 423368013119 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 423368013120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 423368013121 putative acyl-acceptor binding pocket; other site 423368013122 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 423368013123 LexA repressor; Validated; Region: PRK00215 423368013124 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 423368013125 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 423368013126 Catalytic site [active] 423368013127 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 423368013128 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 423368013129 hypothetical protein; Provisional; Region: PRK10428 423368013130 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 423368013131 metal binding site 2 [ion binding]; metal-binding site 423368013132 putative DNA binding helix; other site 423368013133 metal binding site 1 [ion binding]; metal-binding site 423368013134 dimer interface [polypeptide binding]; other site 423368013135 structural Zn2+ binding site [ion binding]; other site 423368013136 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 423368013137 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 423368013138 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 423368013139 FMN binding site [chemical binding]; other site 423368013140 active site 423368013141 catalytic residues [active] 423368013142 substrate binding site [chemical binding]; other site 423368013143 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 423368013144 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 423368013145 NADP binding site [chemical binding]; other site 423368013146 dimer interface [polypeptide binding]; other site 423368013147 replicative DNA helicase; Provisional; Region: PRK08006 423368013148 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 423368013149 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 423368013150 Walker A motif; other site 423368013151 ATP binding site [chemical binding]; other site 423368013152 Walker B motif; other site 423368013153 DNA binding loops [nucleotide binding] 423368013154 alanine racemase; Reviewed; Region: alr; PRK00053 423368013155 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 423368013156 active site 423368013157 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 423368013158 substrate binding site [chemical binding]; other site 423368013159 catalytic residues [active] 423368013160 dimer interface [polypeptide binding]; other site 423368013161 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 423368013162 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 423368013163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368013164 homodimer interface [polypeptide binding]; other site 423368013165 catalytic residue [active] 423368013166 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 423368013167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368013168 active site 423368013169 motif I; other site 423368013170 motif II; other site 423368013171 Uncharacterized conserved protein [Function unknown]; Region: COG0432 423368013172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 423368013173 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 423368013174 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 423368013175 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 423368013176 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 423368013177 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 423368013178 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 423368013179 dimer interface [polypeptide binding]; other site 423368013180 ssDNA binding site [nucleotide binding]; other site 423368013181 tetramer (dimer of dimers) interface [polypeptide binding]; other site 423368013182 hypothetical protein; Validated; Region: PRK09039 423368013183 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 423368013184 Outer membrane efflux protein; Region: OEP; pfam02321 423368013185 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 423368013186 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 423368013187 HlyD family secretion protein; Region: HlyD_3; pfam13437 423368013188 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013189 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013190 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013191 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013192 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013193 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013194 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013195 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013196 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013197 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013198 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013199 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013200 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013201 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013202 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013203 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013204 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013205 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013206 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013207 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013208 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013209 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013210 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013211 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013212 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013213 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013214 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013215 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 423368013216 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013217 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013218 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013219 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013220 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013221 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013222 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 423368013223 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013224 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 423368013225 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013226 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 423368013227 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 423368013228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 423368013229 Walker A/P-loop; other site 423368013230 ATP binding site [chemical binding]; other site 423368013231 Q-loop/lid; other site 423368013232 ABC transporter signature motif; other site 423368013233 Walker B; other site 423368013234 D-loop; other site 423368013235 H-loop/switch region; other site 423368013236 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 423368013237 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 423368013238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 423368013239 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 423368013240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368013241 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 423368013242 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 423368013243 DNA binding residues [nucleotide binding] 423368013244 dimer interface [polypeptide binding]; other site 423368013245 [2Fe-2S] cluster binding site [ion binding]; other site 423368013246 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 423368013247 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 423368013248 putative C-terminal domain interface [polypeptide binding]; other site 423368013249 putative GSH binding site (G-site) [chemical binding]; other site 423368013250 putative dimer interface [polypeptide binding]; other site 423368013251 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 423368013252 putative N-terminal domain interface [polypeptide binding]; other site 423368013253 putative dimer interface [polypeptide binding]; other site 423368013254 putative substrate binding pocket (H-site) [chemical binding]; other site 423368013255 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 423368013256 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 423368013257 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 423368013258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 423368013259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368013260 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 423368013261 putative dimerization interface [polypeptide binding]; other site 423368013262 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 423368013263 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 423368013264 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 423368013265 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 423368013266 Na binding site [ion binding]; other site 423368013267 Predicted membrane protein [Function unknown]; Region: COG3162 423368013268 acetyl-CoA synthetase; Provisional; Region: PRK00174 423368013269 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 423368013270 active site 423368013271 CoA binding site [chemical binding]; other site 423368013272 acyl-activating enzyme (AAE) consensus motif; other site 423368013273 AMP binding site [chemical binding]; other site 423368013274 acetate binding site [chemical binding]; other site 423368013275 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 423368013276 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 423368013277 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 423368013278 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 423368013279 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 423368013280 heme lyase subunit NrfE; Provisional; Region: PRK10369 423368013281 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 423368013282 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 423368013283 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 423368013284 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 423368013285 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 423368013286 Sel1-like repeats; Region: SEL1; smart00671 423368013287 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 423368013288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368013289 Coenzyme A binding pocket [chemical binding]; other site 423368013290 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 423368013291 dimer interface [polypeptide binding]; other site 423368013292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 423368013293 hypothetical protein; Provisional; Region: PRK10220 423368013294 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 423368013295 PhnA protein; Region: PhnA; pfam03831 423368013296 proline/glycine betaine transporter; Provisional; Region: PRK10642 423368013297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368013298 putative substrate translocation pore; other site 423368013299 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 423368013300 sensor protein BasS/PmrB; Provisional; Region: PRK10755 423368013301 HAMP domain; Region: HAMP; pfam00672 423368013302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368013303 dimer interface [polypeptide binding]; other site 423368013304 phosphorylation site [posttranslational modification] 423368013305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368013306 ATP binding site [chemical binding]; other site 423368013307 Mg2+ binding site [ion binding]; other site 423368013308 G-X-G motif; other site 423368013309 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 423368013310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368013311 active site 423368013312 phosphorylation site [posttranslational modification] 423368013313 intermolecular recognition site; other site 423368013314 dimerization interface [polypeptide binding]; other site 423368013315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368013316 DNA binding site [nucleotide binding] 423368013317 putative metal dependent hydrolase; Provisional; Region: PRK11598 423368013318 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 423368013319 Sulfatase; Region: Sulfatase; pfam00884 423368013320 arginine:agmatin antiporter; Provisional; Region: PRK10644 423368013321 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 423368013322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368013323 arginine decarboxylase; Provisional; Region: PRK15029 423368013324 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 423368013325 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 423368013326 homodimer interface [polypeptide binding]; other site 423368013327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 423368013328 catalytic residue [active] 423368013329 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 423368013330 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 423368013331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368013332 alpha-galactosidase; Provisional; Region: PRK15076 423368013333 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 423368013334 NAD binding site [chemical binding]; other site 423368013335 sugar binding site [chemical binding]; other site 423368013336 divalent metal binding site [ion binding]; other site 423368013337 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 423368013338 dimer interface [polypeptide binding]; other site 423368013339 melibiose:sodium symporter; Provisional; Region: PRK10429 423368013340 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 423368013341 fumarate hydratase; Provisional; Region: PRK15389 423368013342 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 423368013343 Fumarase C-terminus; Region: Fumerase_C; pfam05683 423368013344 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 423368013345 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 423368013346 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 423368013347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368013348 active site 423368013349 phosphorylation site [posttranslational modification] 423368013350 intermolecular recognition site; other site 423368013351 dimerization interface [polypeptide binding]; other site 423368013352 sensory histidine kinase DcuS; Provisional; Region: PRK11086 423368013353 PAS domain; Region: PAS; smart00091 423368013354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368013355 ATP binding site [chemical binding]; other site 423368013356 Mg2+ binding site [ion binding]; other site 423368013357 G-X-G motif; other site 423368013358 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 423368013359 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 423368013360 putative [Fe4-S4] binding site [ion binding]; other site 423368013361 putative molybdopterin cofactor binding site [chemical binding]; other site 423368013362 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 423368013363 putative molybdopterin cofactor binding site; other site 423368013364 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 423368013365 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 423368013366 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 423368013367 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 423368013368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 423368013369 SdiA-regulated; Region: SdiA-regulated; cd09971 423368013370 putative active site [active] 423368013371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 423368013372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368013373 DNA binding residues [nucleotide binding] 423368013374 dimerization interface [polypeptide binding]; other site 423368013375 AraC family transcriptional regulator; Provisional; Region: PRK15186 423368013376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368013377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 423368013378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368013379 Coenzyme A binding pocket [chemical binding]; other site 423368013380 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 423368013381 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 423368013382 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368013383 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368013384 Enterobacteria AfaD invasin protein; Region: AfaD; cl05376 423368013385 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 423368013386 hinge region; other site 423368013387 alpha helical domain; other site 423368013388 FaeA-like protein; Region: FaeA; pfam04703 423368013389 SdiA-regulated; Region: SdiA-regulated; pfam06977 423368013390 SdiA-regulated; Region: SdiA-regulated; cd09971 423368013391 putative active site [active] 423368013392 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 423368013393 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 423368013394 active site 423368013395 putative transcriptional regulator; Provisional; Region: PRK11640 423368013396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 423368013397 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 423368013398 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 423368013399 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 423368013400 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 423368013401 DsbD alpha interface [polypeptide binding]; other site 423368013402 catalytic residues [active] 423368013403 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 423368013404 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 423368013405 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 423368013406 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 423368013407 Aspartase; Region: Aspartase; cd01357 423368013408 active sites [active] 423368013409 tetramer interface [polypeptide binding]; other site 423368013410 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 423368013411 putative transporter; Provisional; Region: PRK11021 423368013412 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 423368013413 oligomerisation interface [polypeptide binding]; other site 423368013414 mobile loop; other site 423368013415 roof hairpin; other site 423368013416 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 423368013417 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 423368013418 ring oligomerisation interface [polypeptide binding]; other site 423368013419 ATP/Mg binding site [chemical binding]; other site 423368013420 stacking interactions; other site 423368013421 hinge regions; other site 423368013422 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 423368013423 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 423368013424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368013425 FeS/SAM binding site; other site 423368013426 elongation factor P; Validated; Region: PRK00529 423368013427 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 423368013428 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 423368013429 RNA binding site [nucleotide binding]; other site 423368013430 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 423368013431 RNA binding site [nucleotide binding]; other site 423368013432 Predicted small secreted protein [Function unknown]; Region: COG5510 423368013433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 423368013434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368013435 DNA binding residues [nucleotide binding] 423368013436 dimerization interface [polypeptide binding]; other site 423368013437 multidrug efflux system protein; Provisional; Region: PRK11431 423368013438 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 423368013439 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 423368013440 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 423368013441 Iron-sulfur protein interface; other site 423368013442 proximal quinone binding site [chemical binding]; other site 423368013443 C-subunit interface; other site 423368013444 distal quinone binding site; other site 423368013445 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 423368013446 D-subunit interface [polypeptide binding]; other site 423368013447 Iron-sulfur protein interface; other site 423368013448 proximal quinone binding site [chemical binding]; other site 423368013449 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 423368013450 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 423368013451 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 423368013452 L-aspartate oxidase; Provisional; Region: PRK06175 423368013453 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 423368013454 poxB regulator PoxA; Provisional; Region: PRK09350 423368013455 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 423368013456 motif 1; other site 423368013457 dimer interface [polypeptide binding]; other site 423368013458 active site 423368013459 motif 2; other site 423368013460 motif 3; other site 423368013461 inner membrane transporter YjeM; Provisional; Region: PRK15238 423368013462 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 423368013463 putative mechanosensitive channel protein; Provisional; Region: PRK10929 423368013464 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 423368013465 Mechanosensitive ion channel; Region: MS_channel; pfam00924 423368013466 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 423368013467 GTPase RsgA; Reviewed; Region: PRK12288 423368013468 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 423368013469 RNA binding site [nucleotide binding]; other site 423368013470 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 423368013471 GTPase/Zn-binding domain interface [polypeptide binding]; other site 423368013472 GTP/Mg2+ binding site [chemical binding]; other site 423368013473 G4 box; other site 423368013474 G5 box; other site 423368013475 G1 box; other site 423368013476 Switch I region; other site 423368013477 G2 box; other site 423368013478 G3 box; other site 423368013479 Switch II region; other site 423368013480 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 423368013481 catalytic site [active] 423368013482 putative active site [active] 423368013483 putative substrate binding site [chemical binding]; other site 423368013484 dimer interface [polypeptide binding]; other site 423368013485 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 423368013486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 423368013487 substrate binding pocket [chemical binding]; other site 423368013488 membrane-bound complex binding site; other site 423368013489 hinge residues; other site 423368013490 epoxyqueuosine reductase; Region: TIGR00276 423368013491 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 423368013492 putative carbohydrate kinase; Provisional; Region: PRK10565 423368013493 Uncharacterized conserved protein [Function unknown]; Region: COG0062 423368013494 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 423368013495 putative substrate binding site [chemical binding]; other site 423368013496 putative ATP binding site [chemical binding]; other site 423368013497 ADP-binding protein; Provisional; Region: PRK10646 423368013498 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 423368013499 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 423368013500 active site 423368013501 metal binding site [ion binding]; metal-binding site 423368013502 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 423368013503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368013504 ATP binding site [chemical binding]; other site 423368013505 Mg2+ binding site [ion binding]; other site 423368013506 G-X-G motif; other site 423368013507 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 423368013508 ATP binding site [chemical binding]; other site 423368013509 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 423368013510 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 423368013511 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 423368013512 bacterial Hfq-like; Region: Hfq; cd01716 423368013513 hexamer interface [polypeptide binding]; other site 423368013514 Sm1 motif; other site 423368013515 RNA binding site [nucleotide binding]; other site 423368013516 Sm2 motif; other site 423368013517 GTPase HflX; Provisional; Region: PRK11058 423368013518 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 423368013519 HflX GTPase family; Region: HflX; cd01878 423368013520 G1 box; other site 423368013521 GTP/Mg2+ binding site [chemical binding]; other site 423368013522 Switch I region; other site 423368013523 G2 box; other site 423368013524 G3 box; other site 423368013525 Switch II region; other site 423368013526 G4 box; other site 423368013527 G5 box; other site 423368013528 FtsH protease regulator HflK; Provisional; Region: PRK10930 423368013529 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 423368013530 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 423368013531 FtsH protease regulator HflC; Provisional; Region: PRK11029 423368013532 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 423368013533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 423368013534 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 423368013535 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 423368013536 GDP-binding site [chemical binding]; other site 423368013537 ACT binding site; other site 423368013538 IMP binding site; other site 423368013539 Predicted transcriptional regulator [Transcription]; Region: COG1959 423368013540 transcriptional repressor NsrR; Provisional; Region: PRK11014 423368013541 exoribonuclease R; Provisional; Region: PRK11642 423368013542 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 423368013543 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 423368013544 RNB domain; Region: RNB; pfam00773 423368013545 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 423368013546 RNA binding site [nucleotide binding]; other site 423368013547 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 423368013548 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 423368013549 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 423368013550 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 423368013551 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 423368013552 Ion channel; Region: Ion_trans_2; pfam07885 423368013553 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 423368013554 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 423368013555 Predicted membrane protein [Function unknown]; Region: COG3766 423368013556 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 423368013557 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 423368013558 Predicted integral membrane protein [Function unknown]; Region: COG5463 423368013559 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 423368013560 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 423368013561 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 423368013562 FAD binding site [chemical binding]; other site 423368013563 substrate binding site [chemical binding]; other site 423368013564 catalytic residues [active] 423368013565 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368013566 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 423368013567 esterase; Provisional; Region: PRK10566 423368013568 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 423368013569 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 423368013570 transcriptional repressor UlaR; Provisional; Region: PRK13509 423368013571 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 423368013572 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 423368013573 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 423368013574 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 423368013575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 423368013576 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 423368013577 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 423368013578 active site 423368013579 P-loop; other site 423368013580 phosphorylation site [posttranslational modification] 423368013581 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368013582 active site 423368013583 phosphorylation site [posttranslational modification] 423368013584 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 423368013585 active site 423368013586 dimer interface [polypeptide binding]; other site 423368013587 magnesium binding site [ion binding]; other site 423368013588 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 423368013589 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 423368013590 AP (apurinic/apyrimidinic) site pocket; other site 423368013591 DNA interaction; other site 423368013592 Metal-binding active site; metal-binding site 423368013593 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 423368013594 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 423368013595 intersubunit interface [polypeptide binding]; other site 423368013596 active site 423368013597 Zn2+ binding site [ion binding]; other site 423368013598 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 423368013599 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 423368013600 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 423368013601 dimer interface [polypeptide binding]; other site 423368013602 ssDNA binding site [nucleotide binding]; other site 423368013603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 423368013604 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 423368013605 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 423368013606 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 423368013607 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 423368013608 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 423368013609 EamA-like transporter family; Region: EamA; pfam00892 423368013610 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 423368013611 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 423368013612 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 423368013613 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 423368013614 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 423368013615 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 423368013616 DKNYY family; Region: DKNYY; pfam13644 423368013617 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 423368013618 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 423368013619 Hemerythrin-like domain; Region: Hr-like; cd12108 423368013620 Fe binding site [ion binding]; other site 423368013621 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 423368013622 EamA-like transporter family; Region: EamA; pfam00892 423368013623 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 423368013624 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 423368013625 NADP binding site [chemical binding]; other site 423368013626 Predicted transcriptional regulators [Transcription]; Region: COG1733 423368013627 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 423368013628 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 423368013629 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 423368013630 active site 423368013631 metal binding site [ion binding]; metal-binding site 423368013632 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 423368013633 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 423368013634 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 423368013635 active site 423368013636 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 423368013637 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 423368013638 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 423368013639 Domain of unknown function DUF21; Region: DUF21; pfam01595 423368013640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 423368013641 Transporter associated domain; Region: CorC_HlyC; smart01091 423368013642 methionine sulfoxide reductase A; Provisional; Region: PRK00058 423368013643 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 423368013644 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 423368013645 Surface antigen; Region: Bac_surface_Ag; pfam01103 423368013646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 423368013647 Family of unknown function (DUF490); Region: DUF490; pfam04357 423368013648 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 423368013649 putative active site pocket [active] 423368013650 dimerization interface [polypeptide binding]; other site 423368013651 putative catalytic residue [active] 423368013652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368013653 D-galactonate transporter; Region: 2A0114; TIGR00893 423368013654 putative substrate translocation pore; other site 423368013655 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 423368013656 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 423368013657 active site 423368013658 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 423368013659 dimer interface [polypeptide binding]; other site 423368013660 substrate binding site [chemical binding]; other site 423368013661 metal binding sites [ion binding]; metal-binding site 423368013662 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 423368013663 AMP binding site [chemical binding]; other site 423368013664 metal binding site [ion binding]; metal-binding site 423368013665 active site 423368013666 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 423368013667 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 423368013668 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 423368013669 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 423368013670 hypothetical protein; Provisional; Region: PRK05255 423368013671 peptidase PmbA; Provisional; Region: PRK11040 423368013672 cytochrome b562; Provisional; Region: PRK15058 423368013673 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 423368013674 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 423368013675 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 423368013676 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 423368013677 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 423368013678 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 423368013679 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 423368013680 active site 423368013681 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 423368013682 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 423368013683 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 423368013684 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 423368013685 HTH domain; Region: HTH_11; pfam08279 423368013686 Mga helix-turn-helix domain; Region: Mga; pfam05043 423368013687 PRD domain; Region: PRD; pfam00874 423368013688 PRD domain; Region: PRD; pfam00874 423368013689 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 423368013690 active site 423368013691 P-loop; other site 423368013692 phosphorylation site [posttranslational modification] 423368013693 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 423368013694 active site 423368013695 phosphorylation site [posttranslational modification] 423368013696 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 423368013697 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 423368013698 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 423368013699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368013700 FeS/SAM binding site; other site 423368013701 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 423368013702 ATP cone domain; Region: ATP-cone; pfam03477 423368013703 Class III ribonucleotide reductase; Region: RNR_III; cd01675 423368013704 effector binding site; other site 423368013705 active site 423368013706 Zn binding site [ion binding]; other site 423368013707 glycine loop; other site 423368013708 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 423368013709 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 423368013710 Ca binding site [ion binding]; other site 423368013711 active site 423368013712 catalytic site [active] 423368013713 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 423368013714 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 423368013715 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 423368013716 active site turn [active] 423368013717 phosphorylation site [posttranslational modification] 423368013718 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 423368013719 trehalose repressor; Provisional; Region: treR; PRK09492 423368013720 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368013721 DNA binding site [nucleotide binding] 423368013722 domain linker motif; other site 423368013723 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 423368013724 dimerization interface [polypeptide binding]; other site 423368013725 ligand binding site [chemical binding]; other site 423368013726 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 423368013727 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 423368013728 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 423368013729 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 423368013730 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 423368013731 Soluble P-type ATPase [General function prediction only]; Region: COG4087 423368013732 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 423368013733 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 423368013734 homotrimer interaction site [polypeptide binding]; other site 423368013735 putative active site [active] 423368013736 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 423368013737 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 423368013738 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 423368013739 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 423368013740 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 423368013741 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 423368013742 Arginine repressor [Transcription]; Region: ArgR; COG1438 423368013743 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 423368013744 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 423368013745 Predicted membrane protein [Function unknown]; Region: COG1288 423368013746 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 423368013747 ornithine carbamoyltransferase; Validated; Region: PRK02102 423368013748 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 423368013749 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 423368013750 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 423368013751 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 423368013752 putative substrate binding site [chemical binding]; other site 423368013753 nucleotide binding site [chemical binding]; other site 423368013754 nucleotide binding site [chemical binding]; other site 423368013755 homodimer interface [polypeptide binding]; other site 423368013756 arginine deiminase; Provisional; Region: PRK01388 423368013757 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 423368013758 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 423368013759 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 423368013760 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 423368013761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 423368013762 RNase E inhibitor protein; Provisional; Region: PRK11191 423368013763 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 423368013764 active site 423368013765 dinuclear metal binding site [ion binding]; other site 423368013766 dimerization interface [polypeptide binding]; other site 423368013767 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 423368013768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 423368013769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368013770 Coenzyme A binding pocket [chemical binding]; other site 423368013771 Predicted membrane protein [Function unknown]; Region: COG4269 423368013772 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 423368013773 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 423368013774 HIGH motif; other site 423368013775 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 423368013776 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 423368013777 active site 423368013778 KMSKS motif; other site 423368013779 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 423368013780 tRNA binding surface [nucleotide binding]; other site 423368013781 anticodon binding site; other site 423368013782 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 423368013783 DNA polymerase III subunit chi; Validated; Region: PRK05728 423368013784 multifunctional aminopeptidase A; Provisional; Region: PRK00913 423368013785 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 423368013786 interface (dimer of trimers) [polypeptide binding]; other site 423368013787 Substrate-binding/catalytic site; other site 423368013788 Zn-binding sites [ion binding]; other site 423368013789 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 423368013790 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 423368013791 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 423368013792 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 423368013793 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 423368013794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 423368013795 DNA binding site [nucleotide binding] 423368013796 domain linker motif; other site 423368013797 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 423368013798 putative dimerization interface [polypeptide binding]; other site 423368013799 putative ligand binding site [chemical binding]; other site 423368013800 gluconate transporter; Region: gntP; TIGR00791 423368013801 fructuronate transporter; Provisional; Region: PRK10034; cl15264 423368013802 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 423368013803 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 423368013804 NADP binding site [chemical binding]; other site 423368013805 homodimer interface [polypeptide binding]; other site 423368013806 active site 423368013807 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 423368013808 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 423368013809 putative NAD(P) binding site [chemical binding]; other site 423368013810 catalytic Zn binding site [ion binding]; other site 423368013811 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 423368013812 ATP-binding site [chemical binding]; other site 423368013813 Gluconate-6-phosphate binding site [chemical binding]; other site 423368013814 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 423368013815 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 423368013816 putative NAD(P) binding site [chemical binding]; other site 423368013817 putative substrate binding site [chemical binding]; other site 423368013818 catalytic Zn binding site [ion binding]; other site 423368013819 structural Zn binding site [ion binding]; other site 423368013820 dimer interface [polypeptide binding]; other site 423368013821 integrase; Provisional; Region: PRK09692 423368013822 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 423368013823 active site 423368013824 Int/Topo IB signature motif; other site 423368013825 DEAD-like helicases superfamily; Region: DEXDc; smart00487 423368013826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368013827 ATP binding site [chemical binding]; other site 423368013828 putative Mg++ binding site [ion binding]; other site 423368013829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 423368013830 nucleotide binding region [chemical binding]; other site 423368013831 ATP-binding site [chemical binding]; other site 423368013832 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 423368013833 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 423368013834 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 423368013835 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 423368013836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 423368013837 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 423368013838 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 423368013839 active site 423368013840 metal binding site [ion binding]; metal-binding site 423368013841 interdomain interaction site; other site 423368013842 D5 N terminal like; Region: D5_N; smart00885 423368013843 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 423368013844 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 423368013845 hypothetical protein; Provisional; Region: PRK12378 423368013846 Methyltransferase domain; Region: Methyltransf_23; pfam13489 423368013847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368013848 S-adenosylmethionine binding site [chemical binding]; other site 423368013849 Methyltransferase domain; Region: Methyltransf_31; pfam13847 423368013850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368013851 S-adenosylmethionine binding site [chemical binding]; other site 423368013852 hypothetical protein; Provisional; Region: PRK13687 423368013853 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 423368013854 Uncharacterized conserved protein [Function unknown]; Region: COG3439 423368013855 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 423368013856 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 423368013857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 423368013858 DNA-binding site [nucleotide binding]; DNA binding site 423368013859 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 423368013860 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 423368013861 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 423368013862 active site 423368013863 HIGH motif; other site 423368013864 dimer interface [polypeptide binding]; other site 423368013865 KMSKS motif; other site 423368013866 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 423368013867 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 423368013868 aspartate racemase; Region: asp_race; TIGR00035 423368013869 cell density-dependent motility repressor; Provisional; Region: PRK10082 423368013870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 423368013871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 423368013872 dimerization interface [polypeptide binding]; other site 423368013873 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 423368013874 isoaspartyl dipeptidase; Provisional; Region: PRK10657 423368013875 dimer interface [polypeptide binding]; other site 423368013876 active site 423368013877 hypothetical protein; Provisional; Region: PRK10519 423368013878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 423368013879 Nucleoside recognition; Region: Gate; pfam07670 423368013880 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 423368013881 Predicted membrane protein [Function unknown]; Region: COG2733 423368013882 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 423368013883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 423368013884 putative substrate translocation pore; other site 423368013885 hypothetical protein; Provisional; Region: PRK09956 423368013886 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 423368013887 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 423368013888 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 423368013889 NAD(P) binding site [chemical binding]; other site 423368013890 catalytic residues [active] 423368013891 Protein of unknown function DUF91; Region: DUF91; cl00709 423368013892 Uncharacterized conserved protein [Function unknown]; Region: COG3586 423368013893 Uncharacterized conserved protein [Function unknown]; Region: COG1479 423368013894 Protein of unknown function DUF262; Region: DUF262; pfam03235 423368013895 Uncharacterized conserved protein [Function unknown]; Region: COG3472 423368013896 endoribonuclease SymE; Provisional; Region: PRK13605 423368013897 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 423368013898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 423368013899 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 423368013900 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 423368013901 HsdM N-terminal domain; Region: HsdM_N; pfam12161 423368013902 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 423368013903 Methyltransferase domain; Region: Methyltransf_26; pfam13659 423368013904 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 423368013905 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 423368013906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 423368013907 ATP binding site [chemical binding]; other site 423368013908 putative Mg++ binding site [ion binding]; other site 423368013909 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 423368013910 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 423368013911 P-loop, Walker A motif; other site 423368013912 Base recognition motif; other site 423368013913 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 423368013914 Uncharacterized small protein [Function unknown]; Region: COG2879 423368013915 carbon starvation protein A; Provisional; Region: PRK15015 423368013916 Carbon starvation protein CstA; Region: CstA; pfam02554 423368013917 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 423368013918 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 423368013919 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 423368013920 dimer interface [polypeptide binding]; other site 423368013921 ligand binding site [chemical binding]; other site 423368013922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 423368013923 dimerization interface [polypeptide binding]; other site 423368013924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 423368013925 dimer interface [polypeptide binding]; other site 423368013926 putative CheW interface [polypeptide binding]; other site 423368013927 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 423368013928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368013929 Walker A motif; other site 423368013930 ATP binding site [chemical binding]; other site 423368013931 Walker B motif; other site 423368013932 arginine finger; other site 423368013933 Transcriptional antiterminator [Transcription]; Region: COG3933 423368013934 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368013935 active pocket/dimerization site; other site 423368013936 active site 423368013937 phosphorylation site [posttranslational modification] 423368013938 PRD domain; Region: PRD; pfam00874 423368013939 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 423368013940 active pocket/dimerization site; other site 423368013941 active site 423368013942 phosphorylation site [posttranslational modification] 423368013943 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 423368013944 active site 423368013945 phosphorylation site [posttranslational modification] 423368013946 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 423368013947 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 423368013948 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 423368013949 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 423368013950 dimer interface [polypeptide binding]; other site 423368013951 active site 423368013952 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 423368013953 dimer interface [polypeptide binding]; other site 423368013954 active site 423368013955 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 423368013956 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 423368013957 putative active site [active] 423368013958 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 423368013959 phosphoglycerol transferase I; Provisional; Region: PRK03776 423368013960 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 423368013961 hypothetical protein; Provisional; Region: PRK11667 423368013962 DNA replication protein DnaC; Validated; Region: PRK07952 423368013963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 423368013964 Walker A motif; other site 423368013965 ATP binding site [chemical binding]; other site 423368013966 Walker B motif; other site 423368013967 primosomal protein DnaI; Provisional; Region: PRK02854 423368013968 hypothetical protein; Provisional; Region: PRK09917 423368013969 Uncharacterized conserved protein [Function unknown]; Region: COG2966 423368013970 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 423368013971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 423368013972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368013973 DNA binding residues [nucleotide binding] 423368013974 dimerization interface [polypeptide binding]; other site 423368013975 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 423368013976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 423368013977 DNA binding residues [nucleotide binding] 423368013978 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 423368013979 putative deacylase active site [active] 423368013980 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 423368013981 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 423368013982 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 423368013983 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 423368013984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 423368013985 metal binding site [ion binding]; metal-binding site 423368013986 active site 423368013987 I-site; other site 423368013988 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 423368013989 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 423368013990 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 423368013991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 423368013992 S-adenosylmethionine binding site [chemical binding]; other site 423368013993 DNA polymerase III subunit psi; Validated; Region: PRK06856 423368013994 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 423368013995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 423368013996 Coenzyme A binding pocket [chemical binding]; other site 423368013997 dUMP phosphatase; Provisional; Region: PRK09449 423368013998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368013999 motif II; other site 423368014000 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 423368014001 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 423368014002 G1 box; other site 423368014003 putative GEF interaction site [polypeptide binding]; other site 423368014004 GTP/Mg2+ binding site [chemical binding]; other site 423368014005 Switch I region; other site 423368014006 G2 box; other site 423368014007 G3 box; other site 423368014008 Switch II region; other site 423368014009 G4 box; other site 423368014010 G5 box; other site 423368014011 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 423368014012 periplasmic protein; Provisional; Region: PRK10568 423368014013 BON domain; Region: BON; pfam04972 423368014014 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 423368014015 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 423368014016 active site 423368014017 nucleophile elbow; other site 423368014018 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 423368014019 active site 423368014020 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 423368014021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 423368014022 FeS/SAM binding site; other site 423368014023 hypothetical protein; Provisional; Region: PRK10977 423368014024 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 423368014025 intersubunit interface [polypeptide binding]; other site 423368014026 active site 423368014027 catalytic residue [active] 423368014028 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 423368014029 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 423368014030 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 423368014031 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 423368014032 phosphopentomutase; Provisional; Region: PRK05362 423368014033 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 423368014034 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 423368014035 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 423368014036 hypothetical protein; Provisional; Region: PRK15301 423368014037 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 423368014038 PapC N-terminal domain; Region: PapC_N; pfam13954 423368014039 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368014040 PapC C-terminal domain; Region: PapC_C; pfam13953 423368014041 putative fimbrial chaperone protein; Provisional; Region: PRK09918 423368014042 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368014043 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368014044 hypothetical protein; Provisional; Region: PRK15302 423368014045 hypothetical protein; Provisional; Region: PRK15303 423368014046 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 423368014047 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 423368014048 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 423368014049 hypothetical protein; Provisional; Region: PRK11246 423368014050 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 423368014051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 423368014052 motif II; other site 423368014053 DNA repair protein RadA; Region: sms; TIGR00416 423368014054 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 423368014055 Walker A motif/ATP binding site; other site 423368014056 ATP binding site [chemical binding]; other site 423368014057 Walker B motif; other site 423368014058 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 423368014059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 423368014060 non-specific DNA binding site [nucleotide binding]; other site 423368014061 salt bridge; other site 423368014062 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 423368014063 sequence-specific DNA binding site [nucleotide binding]; other site 423368014064 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 423368014065 active site 423368014066 (T/H)XGH motif; other site 423368014067 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 423368014068 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 423368014069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368014070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368014071 ABC transporter; Region: ABC_tran_2; pfam12848 423368014072 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 423368014073 lytic murein transglycosylase; Provisional; Region: PRK11619 423368014074 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 423368014075 N-acetyl-D-glucosamine binding site [chemical binding]; other site 423368014076 catalytic residue [active] 423368014077 Trp operon repressor; Provisional; Region: PRK01381 423368014078 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 423368014079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 423368014080 catalytic core [active] 423368014081 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 423368014082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 423368014083 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 423368014084 hypothetical protein; Provisional; Region: PRK10756 423368014085 CreA protein; Region: CreA; pfam05981 423368014086 DNA-binding response regulator CreB; Provisional; Region: PRK11083 423368014087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368014088 active site 423368014089 phosphorylation site [posttranslational modification] 423368014090 intermolecular recognition site; other site 423368014091 dimerization interface [polypeptide binding]; other site 423368014092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368014093 DNA binding site [nucleotide binding] 423368014094 sensory histidine kinase CreC; Provisional; Region: PRK11100 423368014095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 423368014096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 423368014097 dimer interface [polypeptide binding]; other site 423368014098 phosphorylation site [posttranslational modification] 423368014099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 423368014100 ATP binding site [chemical binding]; other site 423368014101 Mg2+ binding site [ion binding]; other site 423368014102 G-X-G motif; other site 423368014103 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 423368014104 putative major fimbrial protein SthE; Provisional; Region: PRK15292 423368014105 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 423368014106 putative fimbrial protein SthD; Provisional; Region: PRK15293 423368014107 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 423368014108 PapC N-terminal domain; Region: PapC_N; pfam13954 423368014109 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 423368014110 PapC C-terminal domain; Region: PapC_C; pfam13953 423368014111 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 423368014112 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 423368014113 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 423368014114 putative fimbrial protein SthA; Provisional; Region: PRK15296 423368014115 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 423368014116 Helix-turn-helix domain; Region: HTH_36; pfam13730 423368014117 two-component response regulator; Provisional; Region: PRK11173 423368014118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 423368014119 active site 423368014120 phosphorylation site [posttranslational modification] 423368014121 intermolecular recognition site; other site 423368014122 dimerization interface [polypeptide binding]; other site 423368014123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 423368014124 DNA binding site [nucleotide binding] 423368014125 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 423368014126 putative RNA methyltransferase; Provisional; Region: PRK10433